|
1
|
Kaur M, Kaur R. Association between Body Composition Characteristics and Bone Mineral Density across Menopausal Transition Stages. J Menopausal Med 2025; 31:12-20. [PMID: 40347162 PMCID: PMC12070117 DOI: 10.6118/jmm.24021] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/10/2024] [Revised: 12/12/2024] [Accepted: 02/10/2025] [Indexed: 05/12/2025] Open
Abstract
OBJECTIVES This cross-sectional study assessed the association between body composition characteristics and bone mineral density (BMD) across different menopausal transition stages. METHODS In total, 320 rural women aged 45-60 years were recruited. Body composition and BMD at different skeletal sites were evaluated by dual energy X-ray absorptiometry. RESULTS The BMD and bone mineral content of the entire hip, lumbar region, and left arm significantly decreased across most of the menopausal transition stages, which was confirmed by Tukey post hoc analysis. Multiple linear regression analysis revealed that BMD at the hip, lumbar region, and left arm were strongly and positively associated with weight. However, BMD was negatively associated with % total body fat (TBF) across all the four menopausal stages except for lumbar BMD at the late postmenopausal stage (Model 1). Lean mass was positively and significantly associated with BMD at all the skeletal sites evaluated except for some fluctuations in lumbar BMD (Model 2). Furthermore, waist circumference was significantly associated with BMD in the late postmenopausal stage (Model 3) . CONCLUSIONS Weight and lean mass are significant predictors of BMD during the menopausal transition and beyond. Furthermore, %TBF may be a negative indicator of BMD.
Collapse
Affiliation(s)
- Maninder Kaur
- Department of Anthropology, Panjab University, Chandigarh, India.
| | - Raminder Kaur
- Department of Anthropology, Panjab University, Chandigarh, India
| |
Collapse
|
|
2
|
Mydlárová Blaščáková M, Lőrinczová Z, Anderková L, Czerwińska-Ledwig O, Mikulová Ľ, Hrušovská H, Jędrzejkiewicz B, Piotrowska A. Relationship Between Vitamin D Receptor Gene BsmI Polymorphism and 25-Hydroxyvitamin D Total Levels in Slovak Postmenopausal Women with Reduced Bone Mineral Density. Genes (Basel) 2025; 16:337. [PMID: 40149488 PMCID: PMC11941902 DOI: 10.3390/genes16030337] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/02/2025] [Revised: 02/25/2025] [Accepted: 03/10/2025] [Indexed: 03/29/2025] Open
Abstract
Objectives: The BsmI polymorphism of the VDR gene (vitamin D receptor) is one of the important genetic variants influencing the development of osteoporosis. Measurement and evaluation of the 25-hydroxyvitamin D (25(OH)D) concentration in individuals with reduced bone mineral density are essential because deficiency of this hormone causes impaired bone mineralization, leads to low BMD (bone mineral density), and influences fracture formation. The aim of the study was to investigate the relationship between the VDR gene BsmI polymorphism and 25(OH)D levels in Slovak postmenopausal women. Materials and Methods: The study population consisted of 287 untreated postmenopausal women, who were divided into three groups based on T-scores: normal (CG = 65), osteopenia (OPE = 126), and osteoporosis (OPO = 96). DNA isolation was performed using a standard protocol. Genetic analyses of the BsmI (rs1544410) polymorphism of the VDR gene were performed using the TaqMan SNP genotyping assays. Biochemical analysis of total 25(OH)D was performed in blood serum using the electrochemiluminescence method. Results: The chi-square test confirmed that the mutant T allele was not associated with the development of osteoporosis (p = 0.419). Through Kruskal-Wallis analysis, we found significant differences (p < 0.05, p < 0.01) in total 25(OH)D concentrations in individual genotypes of the BsmI variant of the VDR gene between the groups of women studied. Conclusions: It can be concluded that the VDR gene and its variant BsmI as well as 25(OH)D total may be relevant markers in the etiology of the search for individuals at risk of osteoporosis.
Collapse
Affiliation(s)
- Marta Mydlárová Blaščáková
- Department of Biology, Faculty of Humanities and Naturel Sciences, University of Prešov in Prešov, Ul. 17 novembra 1, 080 01 Prešov, Slovakia
| | - Zuzana Lőrinczová
- Osteocentre, AGEL Hospital Košice-Šaca a.s., Lúčna 57, 040 15 Košice-Šaca, Slovakia;
| | - Lenka Anderková
- Department of Biology, Faculty of Humanities and Naturel Sciences, University of Prešov in Prešov, Ul. 17 novembra 1, 080 01 Prešov, Slovakia
| | - Olga Czerwińska-Ledwig
- Institute for Basic Sciences, Faculty of Physiotherapy, University of Physical Education, 31-571 Krakow, Poland;
| | - Ľudmila Mikulová
- Department of Medical and Technical Disciplines in Health Care, Faculty of Health Care, University of Prešov in Prešov, Partizánska1, 080 01 Prešov, Slovakia;
| | - Hedviga Hrušovská
- Department of Biology, Faculty of Humanities and Naturel Sciences, University of Prešov in Prešov, Ul. 17 novembra 1, 080 01 Prešov, Slovakia
| | - Bernadeta Jędrzejkiewicz
- Department of Nursing, Faculty of Health Sciences, Vincent Pol University in Lublin, 20-001 Lublin, Poland
| | - Anna Piotrowska
- Institute for Basic Sciences, Faculty of Physiotherapy, University of Physical Education, 31-571 Krakow, Poland;
| |
Collapse
|
|
3
|
Sheptulina AF, Yafarova AA, Mamutova EM, Drapkina OM. Sonographic Features of Rectus Femoris Muscle in Patients with Metabolic Dysfunction-Associated Fatty Liver Disease and Their Correlation with Body Composition Parameters and Muscle Strength: Results of a Single-Center Cross-Sectional Study. Biomedicines 2024; 12:1684. [PMID: 39200149 PMCID: PMC11351426 DOI: 10.3390/biomedicines12081684] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/18/2024] [Revised: 07/15/2024] [Accepted: 07/24/2024] [Indexed: 09/01/2024] Open
Abstract
This study aimed to describe sonographic features of rectus femoris muscle (RFM) in patients with metabolic dysfunction-associated fatty liver disease (MASLD) and their correlation with body composition parameters and muscle strength. A total of 67 patients with MASLD underwent dual-energy X-ray absorptiometry (DEXA), bioimpedance analysis (BIA), muscle strength measurement (grip strength [GS] and chair stand test [CST]), and ultrasound (US) investigation of the RFM in the dominant thigh using a 4 to 18 MHz linear probe. MASLD patients exhibited increased RFM echogenicity, possibly due to fatty infiltration. We confirmed that the greater the subcutaneous fat thickness, the smaller was the muscle mass (p < 0.001), and the lower was the muscle strength (p < 0.001 for GS and p = 0.002 for CST). On the contrary, the greater the anteroposterior diameter (APD) of RFM, the higher was the muscle mass (p < 0.001), and the greater was the muscle strength (p < 0.001 for GS and p = 0.007 for CST). In addition, APD of the RFM and stiffness of RFM exhibited direct correlation with bone mineral density values of the lumbar spine (p = 0.005 for both GS and CST). We concluded that US investigation of the RFM in the dominant thigh can be helpful in identifying MASLD patients at a high risk of musculoskeletal disorders given repeated point-of-care clinical evaluations.
Collapse
Affiliation(s)
- Anna F. Sheptulina
- Department of Fundamental and Applied Aspects of Obesity, National Medical Research Center for Therapy and Preventive Medicine, Moscow 101990, Russia; (A.A.Y.); (E.M.M.); (O.M.D.)
| | - Adel A. Yafarova
- Department of Fundamental and Applied Aspects of Obesity, National Medical Research Center for Therapy and Preventive Medicine, Moscow 101990, Russia; (A.A.Y.); (E.M.M.); (O.M.D.)
| | - Elvira M. Mamutova
- Department of Fundamental and Applied Aspects of Obesity, National Medical Research Center for Therapy and Preventive Medicine, Moscow 101990, Russia; (A.A.Y.); (E.M.M.); (O.M.D.)
| | - Oxana M. Drapkina
- Department of Fundamental and Applied Aspects of Obesity, National Medical Research Center for Therapy and Preventive Medicine, Moscow 101990, Russia; (A.A.Y.); (E.M.M.); (O.M.D.)
- Department of Therapy and Preventive Medicine, A.I. Evdokimov Moscow State University of Medicine and Dentistry, Moscow 127473, Russia
| |
Collapse
|
|
4
|
Alkhunizan MA, AlMasoud N, Abdulmowla MM, Khalid Z, Alshaker M, Alendijani YA. Prevalence of discordance between femoral and lumbar bone mineral density among older adults in a community-based setting. Ann Saudi Med 2024; 44:249-254. [PMID: 39127902 DOI: 10.5144/0256-4947.2024.249] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 08/12/2024] Open
Abstract
BACKGROUND T-score measurement via dual-energy X-ray absorptiometry (DXA) is the gold standard for assessing and classifying the bone mineral density status of patients as normal, osteopenic, or osteoporotic according to the World Health Organization criteria. However, the diagnostic accuracy may be affected by the skeletal site selected for DXA. OBJECTIVES Estimate the prevalence of femoral and lumbar BMD discordance in a community-based setting in Riyadh, Saudi Arabia. DESIGN Cross-sectional. SETTING Polyclinics at a tertiary care center. PATIENTS AND METHODS This study included all patients aged ≥60 years who visited the Department of Family Medicine and underwent DXA screening between 2016 and 2022. MAIN OUTCOME MEASURES Discordance was defined as a difference in BMD status between two skeletal sites. Minor discordance occurs when adjacent sites have different diagnoses; i.e., one site exhibits osteoporosis and the other exhibits osteopenia. In contrast, major discordance occurs when one site exhibits osteoporosis and the other exhibits normal BMD. SAMPLE SIZE 1429 older adults. RESULTS The study patients had a median age of 66 years (60-99, minimum-maximum). The prevalence of discordance was 41.6%, with major discordance present in 2.2% of patients and minor discordance in 39.4%. The distribution of discordance did not differ significantly among the sociodemographic factors. CONCLUSION Discordance is prevalent among the Saudi geriatric population. During the analysis of DXA results, physicians should account for discordance when diagnosing and ruling out osteoporosis in high-risk patients. LIMITATIONS All factors influencing discordance were not explored thoroughly; this study mainly focused on older adults. Furthermore, diverse age groups need to be investigated for a more comprehensive understanding of the analyzed factors.
Collapse
Affiliation(s)
- Muath A Alkhunizan
- From the Department of Family Medicine and Polyclinics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
| | - Nouf AlMasoud
- From the Department of Family Medicine and Polyclinics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
| | | | - Zoha Khalid
- From the Department of Hematology, Guy's and St Thomas' Hospitals NHS Trust, London, United Kingdom
| | - Mohammed Alshaker
- From the Department of Family Medicine and Polyclinics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
| | - Yaser Abdullah Alendijani
- From the Department of Family Medicine and Polyclinics, King Faisal Specialist Hospital and Research Centre, Riyadh, Saudi Arabia
| |
Collapse
|
|
5
|
Wu C, Liu T, Shi Z, Fang L, Jin H, Tong P. Novel nomograms for predicting the risk of low distal bone strength: development and validation in a Chinese population-based observational study. J Orthop Surg Res 2023; 18:70. [PMID: 36717927 PMCID: PMC9885689 DOI: 10.1186/s13018-023-03546-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/28/2022] [Accepted: 01/15/2023] [Indexed: 02/01/2023] Open
Abstract
BACKGROUND This study aims to develop nomogram models based on the speed of sound (SOS) measurements results along with demographic information to predict the risk of low bone strength (LBS) of radius appropriate to the Chinese population of a broad age spectrum. METHODS A population-based cross-sectional study was conducted in 5 outpatient clinics located in Zhejiang, the southern part of China. A total of 38,699 participants from 2013 to 2017 were included. Baseline measurements included SOS of the distal radius and clinical risk factor evaluation. Logistic regression models were used to evaluate prognosis and identify independent predictive factors, which were then utilized to establish nomograms for predicting the low bone strength of radius. The discrimination and calibration of nomograms were validated using the calibration plots, the decision curve analysis (DCA), and the receiver operating characteristics curve (ROC). RESULTS A total of 19,845 of the 38,904 participants ranged in age from 10 to 88 years were selected in this process. LBP nomogram model 1 was constructed based on age, weight, height, BMI, and gender. LBP nomogram model 2 was constructed based on age, height, BMI, and gender. The AUCs for model 1 and model 2 were 0.838 (95% CI: 0.832-0.844) and 0.837 (95% CI: 0.831-0.843), respectively. High-quality calibration plots and DCA in nomogram models were noticed, indicated that the constructed nomogram models were clinically useful. CONCLUSIONS Our study demonstrates that the nomograms established in this study could effectively evaluate the high-risk population groups of distal radius fracture in China.
Collapse
Affiliation(s)
- Congzi Wu
- grid.417400.60000 0004 1799 0055Institute of Orthopaedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053 Zhejiang Province People’s Republic of China ,grid.268505.c0000 0000 8744 8924The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053 Zhejiang Province People’s Republic of China
| | - Ting Liu
- grid.268505.c0000 0000 8744 8924School of Nursing, Zhejiang Chinese Medical University, Hangzhou, 310053 China
| | - Zhenyu Shi
- grid.417400.60000 0004 1799 0055Institute of Orthopaedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053 Zhejiang Province People’s Republic of China ,grid.417400.60000 0004 1799 0055Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhejiang, Chinese Medical University, Hangzhou, 310003 Zhejiang Province People’s Republic of China
| | - Liang Fang
- grid.417400.60000 0004 1799 0055Institute of Orthopaedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053 Zhejiang Province People’s Republic of China ,grid.268505.c0000 0000 8744 8924The First College of Clinical Medicine, Zhejiang Chinese Medical University, Hangzhou, 310053 Zhejiang Province People’s Republic of China
| | - Hongting Jin
- grid.417400.60000 0004 1799 0055Institute of Orthopaedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053 Zhejiang Province People’s Republic of China ,grid.417400.60000 0004 1799 0055Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhejiang, Chinese Medical University, Hangzhou, 310003 Zhejiang Province People’s Republic of China
| | - Peijian Tong
- grid.417400.60000 0004 1799 0055Institute of Orthopaedics and Traumatology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310053 Zhejiang Province People’s Republic of China ,grid.417400.60000 0004 1799 0055Department of Orthopaedic Surgery, The First Affiliated Hospital of Zhejiang, Chinese Medical University, Hangzhou, 310003 Zhejiang Province People’s Republic of China
| |
Collapse
|
|
6
|
Al Zaid H, Alamri MS, AlOfair AA, Alqusaiyer FS, Alorainey AI, Alasqah MI, Sulimani RA. Prevalence and Risk Factors of Discordance Between Hip and Spinal Bone Mineral Density Among Saudi Subjects. Cureus 2022; 14:e27684. [PMID: 36072162 PMCID: PMC9440311 DOI: 10.7759/cureus.27684] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 08/04/2022] [Indexed: 11/15/2022] Open
Abstract
Background Discordance between hip and spine on dual-energy x-ray absorptiometry is a well-known problem in diagnosing osteoporosis. The prevalence and risk factors of this problem have not been studied in the Saudi population. The objective of this study was to document this discordance in our population and its possible risk factors. Materials and methods We analyzed data obtained from subjects who had dual x-ray absorptiometry (DXA) between January 2021 and December 2021 at King Khalid University Hospital, Riyadh, Saudi Arabia. Subjects with the following conditions were excluded: secondary osteoporosis, patients taking anti-osteoporotic agents, patients on steroids or hormonal replacement therapy, hyperparathyroidism, hypoparathyroidism, and chronic renal disease. A total of 1388 patients satisfied our inclusion criteria. World Health Organization (WHO) criteria for diagnosis were implemented. Major discordance was defined as osteoporosis in one site and normal in the other. Minor discordance was defined as a difference of no more than one World Health Organization diagnostic class between two sites. Bivariate statistical analysis was achieved using appropriate statistical tests (chi-square, student’s t-test, one-way analysis of variance, and Pearson’s correlation), based on the type of study and outcome variables. A p-value of < 0.05 and 95% CI were used to report the statistical significance and precision of results. Results A total of 1388 subjects were analyzed, of which, 1196 (86%) were females with a mean age of 58.8 (13.8 SD) and 192 were males with a mean age of 58 (18.0 SD). Lumbar osteoporosis was found in 312 (22.5%) participants while hip osteoporosis was reported in 73 (5.3%) of the participants. Major discordance was documented in 85 (6.1%) of all participants (6.3% of the male and 6.1% of the female patients). All of these subjects had lumbar spine osteoporosis with normal hip bone mineral density (BMD). Minor discordance was found in 591 patients (42.6%). Obesity (BMI > 30) was found to be a risk factor for both major (2.10-11.6, 95% CI) and minor (2.5-11.4, 95% CI) discordance. Conclusion Discordance between hip and spine BMD is common among Saudi subjects. Lumbar spine osteoporosis with normal hip BMD caused this discordance in our subjects. Obesity could be responsible for the occurrence of this discordance. Mechanisms may include higher rate of turnover in spine, technical artifacts in the measurements of lumbar spine BMD, or due to the effects of weight loading. Caution should be exercised when interpreting DXA results, especially in obese subjects.
Collapse
|
|
7
|
Olic Akrapovic I, Radic M, Tonkic A. Is there higher percentage of undetected osteopenia and osteoporosis among patients with ulcerative colitis in Saudi Arabia? World J Gastroenterol 2021; 27:4481-4483. [PMID: 34366618 PMCID: PMC8316908 DOI: 10.3748/wjg.v27.i27.4481] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/17/2021] [Revised: 03/29/2021] [Accepted: 06/25/2021] [Indexed: 02/06/2023] Open
Abstract
Detection of prevalence and development of osteopenia or osteoporosis in patients with inflammatory bowel disease using only bone mineral density could be inappropriate to detect all individuals at risk for osteoporosis. Numerous patients could remain undetected by using only bone mineral density as a screening method, especially in patients with ulcerative colitis. Therefore, trabecular bone score should be used as a complementary method.
Collapse
Affiliation(s)
- Ivna Olic Akrapovic
- Intensive Care Unit of the Department of Internal Medicine, University Hospital Centre Split, Split 21000, Croatia
| | - Mislav Radic
- Division of Rheumatology and Clinical Immunology, Centre of Excellence for Systemic Sclerosis Ministry of Health Republic of Croatia, University Hospital Centre Split, Split 21000, Croatia
- School of Medicine, University of Split, Split 21000, Croatia
| | - Ante Tonkic
- School of Medicine, University of Split, Split 21000, Croatia
- Department of Gastroenterology and Hepatology, University Hospital Centre Split, Split 21000, Croatia
| |
Collapse
|
|
8
|
Comment on “A meta-analysis of fracture risk and bone mineral density in patients with systemic sclerosis”. Clin Rheumatol 2020; 39:2243-2244. [DOI: 10.1007/s10067-020-05098-0] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/10/2020] [Revised: 03/31/2020] [Accepted: 04/08/2020] [Indexed: 10/24/2022]
|
|
9
|
Conti F, Balducci S, Pugliese L, D'Errico V, Vitale M, Alessi E, Salerno G, Iacobini C, Menini S, Bollanti L, Nicolucci A, Pugliese G. Correlates of Calcaneal Quantitative Ultrasound Parameters in Patients with Diabetes: The Study on the Assessment of Determinants of Muscle and Bone Strength Abnormalities in Diabetes. J Diabetes Res 2017; 2017:4749619. [PMID: 29057273 PMCID: PMC5625809 DOI: 10.1155/2017/4749619] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/02/2017] [Revised: 07/12/2017] [Accepted: 07/19/2017] [Indexed: 12/25/2022] Open
Abstract
OBJECTIVE Quantitative ultrasound (QUS) provides an estimate of bone mineral density (BMD) and also evaluates bone quality, which has been related to increased fracture risk in people with diabetes. This study aimed at assessing the correlates of calcaneal QUS parameters in diabetic subjects encompassing various degrees of micro and macrovascular complications and a wide-range of peripheral nerve function. METHODS Four hundred consecutive diabetic patients were examined by QUS to obtain values of broadband ultrasound attenuation (BUA), the speed of sound (SOS), quantitative ultrasound index (QUI), and BMD. RESULTS Among surrogate measures of complications, sensory and motor nerve amplitude and heart rate response to cough test and standing correlated with QUS parameters at univariate analysis, together with age, body mass index (BMI), waist circumference, lipid profile, and renal function. Multivariate analysis revealed that BUA, SOS, QUI, and BMD were independently associated with age, male gender, hemoglobin A1c, BMI (or fat, but not fat-free mass), and somatic and autonomic nerve function parameters. CONCLUSIONS These data indicate that peripheral nerve dysfunction is associated with worse QUS parameters, possibly contributing to increased fracture risk in diabetes. The positive relation of QUS measures with adiposity needs further investigation. This trial is registered with ClinicalTrials.gov (NCT01600924).
Collapse
MESH Headings
- Adiposity
- Age Factors
- Aged
- Autonomic Nervous System/physiopathology
- Biomarkers/blood
- Body Mass Index
- Bone Density
- Calcaneus/diagnostic imaging
- Calcaneus/physiopathology
- Chi-Square Distribution
- Cross-Sectional Studies
- Diabetes Mellitus, Type 1/blood
- Diabetes Mellitus, Type 1/complications
- Diabetes Mellitus, Type 1/diagnostic imaging
- Diabetes Mellitus, Type 1/physiopathology
- Diabetes Mellitus, Type 2/blood
- Diabetes Mellitus, Type 2/complications
- Diabetes Mellitus, Type 2/diagnostic imaging
- Diabetes Mellitus, Type 2/physiopathology
- Diabetic Neuropathies/diagnosis
- Diabetic Neuropathies/etiology
- Diabetic Neuropathies/physiopathology
- Female
- Fractures, Bone/diagnosis
- Fractures, Bone/etiology
- Fractures, Bone/physiopathology
- Glycated Hemoglobin/analysis
- Humans
- Linear Models
- Male
- Middle Aged
- Multivariate Analysis
- Predictive Value of Tests
- Prospective Studies
- Risk Factors
- Sex Factors
- Ultrasonography
Collapse
Affiliation(s)
- Francesco Conti
- Department of Clinical and Molecular Medicine, “La Sapienza” University, Via di Grottarossa 1035, 00189 Rome, Italy
- Diabetes Unit, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy
| | - Stefano Balducci
- Department of Clinical and Molecular Medicine, “La Sapienza” University, Via di Grottarossa 1035, 00189 Rome, Italy
- Diabetes Unit, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy
- Metabolic Fitness Association, Via Nomentana 27, Monterotondo, 00015 Rome, Italy
| | - Luca Pugliese
- Radiology Unit, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy
| | - Valeria D'Errico
- Department of Clinical and Molecular Medicine, “La Sapienza” University, Via di Grottarossa 1035, 00189 Rome, Italy
- Diabetes Unit, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy
- Metabolic Fitness Association, Via Nomentana 27, Monterotondo, 00015 Rome, Italy
| | - Martina Vitale
- Department of Clinical and Molecular Medicine, “La Sapienza” University, Via di Grottarossa 1035, 00189 Rome, Italy
- Diabetes Unit, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy
| | - Elena Alessi
- Department of Clinical and Molecular Medicine, “La Sapienza” University, Via di Grottarossa 1035, 00189 Rome, Italy
- Diabetes Unit, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy
| | - Gerardo Salerno
- Department of Clinical and Molecular Medicine, “La Sapienza” University, Via di Grottarossa 1035, 00189 Rome, Italy
- Laboratory of Clinical Chemistry, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy
| | - Carla Iacobini
- Department of Clinical and Molecular Medicine, “La Sapienza” University, Via di Grottarossa 1035, 00189 Rome, Italy
| | - Stefano Menini
- Department of Clinical and Molecular Medicine, “La Sapienza” University, Via di Grottarossa 1035, 00189 Rome, Italy
| | - Lucilla Bollanti
- Department of Clinical and Molecular Medicine, “La Sapienza” University, Via di Grottarossa 1035, 00189 Rome, Italy
- Diabetes Unit, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy
| | - Antonio Nicolucci
- Center for Outcomes Research and Clinical Epidemiology (CORESEARCH), Via Tiziano Vecellio 2, 65124 Pescara, Italy
| | - Giuseppe Pugliese
- Department of Clinical and Molecular Medicine, “La Sapienza” University, Via di Grottarossa 1035, 00189 Rome, Italy
- Diabetes Unit, Sant'Andrea Hospital, Via di Grottarossa 1035, 00189 Rome, Italy
| |
Collapse
|
|
10
|
Wong A. A comparison of peripheral imaging technologies for bone and muscle quantification: a technical review of image acquisition. JOURNAL OF MUSCULOSKELETAL & NEURONAL INTERACTIONS 2016; 16:265-282. [PMID: 27973379 PMCID: PMC5259568] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Indexed: 11/28/2022]
Abstract
The choice of an appropriate imaging technique to quantify bone, muscle, or muscle adiposity needs to be guided by a thorough understanding of its competitive advantages over other modalities balanced by its limitations. This review details the technical machinery and methods behind peripheral quantitative computed tomography (pQCT), high-resolution (HR)-pQCT, and magnetic resonance imaging (MRI) that drive successful depiction of bone and muscle morphometry, densitometry, and structure. It discusses a number of image acquisition settings, the challenges associated with using one versus another, and compares the risk-benefits across the different modalities. Issues related to all modalities including partial volume artifact, beam hardening, calibration, and motion assessment are also detailed. The review further provides data and images to illustrate differences between methods to better guide the reader in selecting an imaging method strategically. Overall, investigators should be cautious of the impact of imaging parameters on image signal or contrast-to-noise-ratios, and the need to report these settings in future publications. The effect of motion should be assessed on images and a decision made to exclude prior to segmentation. A more standardized approach to imaging bone and muscle on pQCT and MRI could enhance comparability across studies and could improve the quality of meta-analyses.
Collapse
Affiliation(s)
- A.K.O. Wong
- Joint Department of Medical Imaging, Toronto General Research Institute, University Health Network, Toronto, ON, Canada,McMaster University, Department of Medicine, Faculty of Health Sciences, Hamilton, ON, Canada,Corresponding author: Andy Kin On Wong, 200 Elizabeth St. Toronto General Hospital, 7EN-238, Toronto, ON M5G 2C4, Canada E-mail:
| |
Collapse
|
|
11
|
Radial quantitative ultrasound and dual energy x-ray absorptiometry: intermethod agreement for bone status assessment in children. BIOMED RESEARCH INTERNATIONAL 2015; 2015:232876. [PMID: 25922831 PMCID: PMC4397423 DOI: 10.1155/2015/232876] [Citation(s) in RCA: 14] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 12/20/2014] [Accepted: 03/18/2015] [Indexed: 11/29/2022]
Abstract
Aim. To validate a radial quantitative ultrasound (QUS) system with dual energy X-ray absorptiometry (DXA), a criterion technique in bone status assessment among children. Methods. Bone health was evaluated using a radial QUS system (Sunlight Omnisense 8000P) to measure the speed of sound (SOS) at one-third distal radius of the nondominant hand and DXA (Hologic QDR) was used to assess whole body bone mineral density (BMD). Results. Some 29.9% of the children were grossly misclassified according to quartiles of BMD and radial SOS. Poor agreement was observed between Z-scores of radial SOS and whole-body BMD (mean difference = 0.6 ± 0.9; 95% limits of agreement = −1.4 to 2.6). With a cut-off value of −1.0, radial SOS yielded satisfactory sensitivity (80%) and specificity (93%) for the detection of children with low BMD. Conclusion. The observed poor agreement in the present study suggests that radial QUS and DXA are not comparable and hence are not interchangeable in evaluating bone status of the children.
Collapse
|
|
12
|
Age, Weight and Body Mass Index Effect on Bone Mineral Density in Postmenopausal Women. HEALTH SCOPE 2014. [DOI: 10.5812/jhs.14075] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/16/2022]
|
|
13
|
Montazerifar F, Karajibani M, Alamian S, Sandoughi M, Zakeri Z, Dashipour AR. Age, Weight and Body Mass Index Effect on Bone Mineral Density in Postmenopausal Women. HEALTH SCOPE 2014. [DOI: 10.17795/jhealthscope-14075] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/25/2022]
|
|
14
|
Salamat MR, Salamat AH, Abedi I, Janghorbani M. Relationship between Weight, Body Mass Index, and Bone Mineral Density in Men Referred for Dual-Energy X-Ray Absorptiometry Scan in Isfahan, Iran. J Osteoporos 2013; 2013:205963. [PMID: 24222888 PMCID: PMC3814102 DOI: 10.1155/2013/205963] [Citation(s) in RCA: 45] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/25/2013] [Revised: 08/29/2013] [Accepted: 08/29/2013] [Indexed: 12/27/2022] Open
Abstract
Objective. Although several studies have investigated the association between body mass index (BMI) and bone mineral density (BMD), the results are inconsistent. The aim of this study was to further investigate the relation between BMI, weight and BMD in an Iranian men population. Methods. A total of 230 men 50-79 years old were examined. All men underwent a standard BMD scans of hip (total hip, femoral neck, trochanter, and femoral shaft) and lumbar vertebrae (L2-L4) using a Dual-Energy X-ray Absorptiometry (DXA) scan and examination of body size. Participants were categorised in two BMI group: normal weight <25.0 kg/m(2) and overweight and obese, BMI ≥ 25 kg/m(2). Results. Compared to men with BMI ≥ 25, the age-adjusted odds ratio of osteopenia was 2.2 (95% CI 0.85, 5.93) and for osteoporosis was 4.4 (1.51, 12.87) for men with BMI < 25. It was noted that BMI and weight was associated with a high BMD, compatible with a diagnosis of osteoporosis. Conclusions. These data indicate that both BMI and weight are associated with BMD of hip and vertebrae and overweight and obesity decreased the risk for osteoporosis. The results of this study highlight the need for osteoporosis prevention strategies in elderly men as well as postmenopausal women.
Collapse
Affiliation(s)
- Mohammad Reza Salamat
- Department of Medical Physics and Medical Engineering, Isfahan University of Medical Sciences, Isfahan 8144503500, Iran
| | - Amir Hossein Salamat
- Isfahan Osteoporosis Diagnosis and Body Composition Center, Isfahan 8143995518, Iran
| | - Iraj Abedi
- Department of Medical Physics and Medical Engineering, Isfahan University of Medical Sciences, Isfahan 8144503500, Iran
| | - Mohsen Janghorbani
- Department of Epidemiology, Isfahan University of Medical Sciences, Isfahan 8144503500, Iran
| |
Collapse
|
|
15
|
Moore MK, Schaefer E. A Comprehensive Regression Tree to Estimate Body Weight from the Skeleton*,†. J Forensic Sci 2011; 56:1115-22. [DOI: 10.1111/j.1556-4029.2011.01819.x] [Citation(s) in RCA: 31] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/28/2022]
|
|
16
|
Fawzy T, Muttappallymyalil J, Sreedharan J, Ahmed A, Alshamsi SOS, Al Ali MSSHBB, Al Balsooshi KA. Association between Body Mass Index and Bone Mineral Density in Patients Referred for Dual-Energy X-Ray Absorptiometry Scan in Ajman, UAE. J Osteoporos 2011; 2011:876309. [PMID: 21772978 PMCID: PMC3135277 DOI: 10.4061/2011/876309] [Citation(s) in RCA: 33] [Impact Index Per Article: 2.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/24/2010] [Revised: 10/30/2010] [Accepted: 03/23/2011] [Indexed: 01/13/2023] Open
Abstract
Body Mass Index (BMI) is a good indicator for measurements of Bone Mineral Density (BMD) which measures the density of minerals present in the bones using a special scan. This study was conducted to assess the association between BMI and status of BMD among 101 individuals who underwent Dual-Energy X-ray Absorptiometry (DEXA) scan. 39 subjects had normal and 62 had low bone mineral density. BMD was low in 82.4% of people with normal BMI, 78.1% among overweight, and 44.2% among obese. There was a statistically significant association between these two variables (P < .001). Low BMD was recorded in 59.1% of females and 76.9% of males. Association between advancing age and lower BMI is an important risk factor in the occurrence of low BMD.
Collapse
Affiliation(s)
- Tarek Fawzy
- Department of Radiodiagnosis, Gulf Medical College Hospital and Research Centre, P.O. Box 4184, Ajman, UAE
| | | | - Jayadevan Sreedharan
- Research Division, Gulf Medical University, P.O. Box 4184, Ajman, UAE,*Jayadevan Sreedharan:
| | - Amal Ahmed
- Research Division, Gulf Medical University, P.O. Box 4184, Ajman, UAE
| | | | | | | |
Collapse
|
|
17
|
Talmant M, Kolta S, Roux C, Haguenauer D, Vedel I, Cassou B, Bossy E, Laugier P. In vivo performance evaluation of bi-directional ultrasonic axial transmission for cortical bone assessment. ULTRASOUND IN MEDICINE & BIOLOGY 2009; 35:912-919. [PMID: 19243881 DOI: 10.1016/j.ultrasmedbio.2008.12.008] [Citation(s) in RCA: 32] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 07/24/2008] [Revised: 11/24/2008] [Accepted: 12/10/2008] [Indexed: 05/27/2023]
Abstract
Our objective was to assess a new quantitative ultrasound device suitable for the measurement of speed of sound in radius. The so-called "bidirectional" technique allows an accurate estimation of velocity based on a compensation for soft tissue effects implemented directly inside the probe. Velocity measurements at 1 MHz of the first arriving signal were performed at the one third distal radius in 358 enrolled women. The average velocity by age decade increases to a peak velocity of 4043 m/s in the class 30-39 y (n = 19) and decreases thereafter. Fracture discrimination was investigated on the subset of the population for which dual-energy x-ray absorptiometry measurement was available, in addition to first arriving signal velocity measurements. The study group consisted of 122 postmenopausal women without history of fracture (group NF) and 44 postmenopausal patients (group F) with osteoporotic fractures (hip, spine, Colles fracture). When adjusted for age and bone mass index, the odds ratio (OR) for fracture prediction by ultrasound velocity, was 1.81 (1.21; 2.70) and OR associated to neck femur BMD was 2.07 (1.31-3.29). For the full model including age and body mass index as cofactors, the area under the receiver operating characteristic curve was 0.77, either for ultrasound velocity or neck femur bone mineral density. Despite the small population and the variety of fractures in the fracture group, our data indicate that the velocity of the first arriving signal measured by bidirectional technique discriminates patients with osteoporotic fracture from controls.
Collapse
Affiliation(s)
- M Talmant
- Université Pierre et Marie Curie-Paris6, Laboratoire d'Imagerie Paramétrique, Paris, France.
| | | | | | | | | | | | | | | |
Collapse
|
|
18
|
Pfeil A, Böttcher J, Mentzel HJ, Lehmann G, Schäfer ML, Kramer A, Petrovitch A, Seidl BE, Malich A, Hein G, Wolf G, Kaiser WA. Multi-site quantitative ultrasound compared to dual energy X-ray absorptiometry in rheumatoid arthritis: effects of body mass index and inflamed soft tissue on reproducibility. Rheumatol Int 2006; 26:1084-90. [PMID: 16736163 DOI: 10.1007/s00296-006-0140-5] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/05/2005] [Accepted: 04/15/2006] [Indexed: 01/01/2023]
Abstract
The objective of the study is to evaluate multi-site quantitative ultrasound (QUS) in comparison to dual energy X-ray absorptiometry (DXA) considering the effects of body mass index (BMI) and disease activity on measurements in patients suffering from rheumatoid arthritis (RA). Sixty-eight patients underwent a cross-sectional analysis of bone mineral density measured by DXA (lumbar spine, total femur) and speed of sound estimated by QUS (phalanx III, distal radius). The short-term precision of QUS was investigated with regard to BMI of healthy individuals and with regard to the level of disease activity in patients suffering from RA. The patients with RA were divided into two BMI groups as well as into low and advanced disease activity groups. The short-term precision of QUS-SOS ranged from 0.90 to 2.55% (healthy controls) and from 0.64 to 1.89% (patients with RA). The association between DXA and QUS parameters were limited in the case of advanced disease activity and pronounced BMI. Low QUS-SOS was observed for advanced disease activity group (QUS-SOS phalanx: -2.5%; QUS-SOS distal radius: -2.1%) in comparison to low disease activity group, whereas only a slight change of DXA parameters was observed. DXA-BMD and QUS parameters revealed higher values with pronounced BMI. The system shows only a short-term precision with limitations in healthy controls with accentuated BMI, as well as in patients with active RA. The application of multi-site QUS seems to be restricted for patients with active inflammation based on soft tissue alteration in RA and for healthy individuals with pronounced body mass.
Collapse
Affiliation(s)
- A Pfeil
- Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller-University Jena, Erlanger Allee 101, Jena 07747, Germany.
| | | | | | | | | | | | | | | | | | | | | | | |
Collapse
|
|
19
|
Böttcher J, Pfeil A, Mentzel H, Kramer A, Schäfer ML, Lehmann G, Eidner T, Petrovitch A, Malich A, Hein G, Kaiser WA. Peripheral bone status in rheumatoid arthritis evaluated by digital X-ray radiogrammetry and compared with multisite quantitative ultrasound. Calcif Tissue Int 2006; 78:25-34. [PMID: 16397736 DOI: 10.1007/s00223-005-0175-8] [Citation(s) in RCA: 29] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/08/2005] [Accepted: 10/04/2005] [Indexed: 01/01/2023]
Abstract
The development of secondary osteoporosis in rheumatoid arthritis (RA) has recently become well recognized, characterized by demineralization at axial and in particular periarticular peripheral bone sites. Our aim was to evaluate multisite quantitative ultrasound (QUS) compared to digital X-ray radiogrammetry (DXR) by the quantification of cortical bone loss dependent on the severity of RA. Fifty-three patients with verified RA underwent QUS measurements (Sunlight Omnisense 7000) with estimation of the speed of sound (QUS-SOS) at the distal radius and at the phalanx of the third digit. Also, bone mineral density (DXR-BMD) and metacarpal index (DXR-MCI) were estimated on metacarpals II-IV using DXR technology. Additionally, Larsen score and Steinbroker stage were assessed. Disease activity of RA was estimated by disease activity score 28 (DAS 28). For the group with minor disease activity (3.2 <or= DAS <or= 5.1), QUS-SOS (phalanx) showed a significant association to DXR-BMD (R = 0.66) and DXR-MCI (R = 0.52). In the case of accentuated disease activity (DAS > 5.1), QUS-SOS of the radius revealed a significant correlation to DXR-BMD (R = 0.71) and DXR-MCI (R = 0.84), whereas for QUS-SOS (phalanx) no significant association to the DXR parameters was shown. The DXR parameters and, to a lesser extent, the QUS data also demonstrated pronounced declines in the case of accentuated disease activity (DAS > 5.1). Both DXR-BMD (-25.9 %, P < 0.01) and DXR-MCI (-38.6 %, P < 0.01) revealed a notable reduction dependent on the severity of RA. Otherwise, QUS-SOS marginally decreased, with -2.6% (radius) and -3.9% (phalanx). DXR revealed a significant reduction of DXR-BMD as well as DXR-MCI dependent on the severity of RA and surpassed multisite QUS as a promising diagnostic tool.
Collapse
Affiliation(s)
- J Böttcher
- Institute of Diagnostic and Interventional Radiology, Friedrich-Schiller University Jena, Jena, Germany.
| | | | | | | | | | | | | | | | | | | | | |
Collapse
|