Wang FJ, Liu AL, Cao J, Lu YH, Zhao QE, Han SX, Meng L. Changes of activities of erythrocyte membrane Na
+-K
+-ATPase and Ca
2+-Mg
2+-ATPase and concentrations of Na
+, K
+, Ca
2+ and Mg
2+ in erythrocytes of patients with liver cirrhosis.
Shijie Huaren Xiaohua Zazhi 2006;
14:722-726. [DOI:
10.11569/wcjd.v14.i7.722]
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Abstract
AIM: To probe the activity changes of erythro-cyte membrane Na+-K+-ATPase (NKA) and Ca2+-Mg2+-ATPase (CMA) and their effects on the concentrations of intracellular sodium, potassi-um, calcium and magnesium in patients with liver cirrhosis.
METHODS: The erythrocyte membrane NKA and CMA activities, and the erythrocyte and serum sodium, potassium, calcium and magnesium (RNa, RK, RCa, RMg; SNa, SK, SCa, SMg) concentrations were measured in 52 patients with decompensated cirrhosis (group A), 36 patients with compensated cirrhosis (group B) and 36 healthy individuals (controls).
RESULTS: Compared with those in control group, the activities of NKA, CMA and the concentrations of RK and RMg in both group A (t = 5.92, P < 0.001; t = 7.21, P < 0.001; t = 2.32, P < 0.02; t = 4.79, P < 0.001) and group B (t = 3.83, P < 0.001; t = 2.53, P < 0.02; t = 2.03, P < 0.05; t = 3.33, P < 0.002) were decreased significantly. Compared with those in group B, the activities of NKA and CMA in group A (t = 2.29, P < 0.05; t = 4.14, P < 0.005) were decreased significantly. The concentrations of RNa and RCa did not differ between among the three groups. In comparison with those in control group, the concentrations of SNa, SK, SCa and SMg were lowered significantly in group A (t = 8.25, P < 0.001; t = 5.73, P < 0.001; t = 9.82, P < 0.001; t = 6.15, P < 0.001); and in comparison with those in group B, the concentrations of SNa, SK, SCa and SMg were also lowered significantly in group A (t = 6.94, P < 0.001; t = 5.00, P < 0.001; t = 5.57, P < 0.001; t = 5.73, P < 0.001). The activities of NKA and CMA and the concentrations of RK, RMg, SNa, SK, SCa and SMg were markedly lower in patients at Child C stage than those at Child B stage (P < 0.01 or P < 0.05). The activities of NKA and CMA and the concentrations of RK, RMg, SNa, SK and SMg were also markedly lower in patients with hepatoencephalopathy than those without hepatoencephalopathy (P < 0.01 or P < 0.05). In group A, the activities of NKA and CMA in patients with decreased SMg concentration were lower than those with normal SMg concentration (16.87 ± 3.19 vs 19.04 ± 3.25; 109.83 ± 13.51 vs 120.13 ± 13.27; both P < 0.05).
CONCLUSION: The deficiencies of potassium and magnesium exist in the patients with liver cirrhosis, deteriorating with advanced disease condition. The decreased NKA and CMA activities lead to a decrease of intracellular potassium and magnesium and increase of sodium and calcium. Magnesium deficiency is one of the reasons for decreased NKA and CMA activities in advanced cirrhosis.
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