In the “proton pump inhibitors era”, a penetrating peptic ulcer (PPU) represents an exceptional cause of abdominal pain, and was more frequently observed in the past where there was not an effective antacid treatment. Ulcer-induced pancreatitis is very rare, too, and manifests with persistent, intense pain radiating to the back. A mild to severe pancreatitis with peripancreatic fluid collection can be observed at imaging. However, only a few cases of association between PPU and emphysematous pancreatitis (EP) have been published in the literature. EP is a rare but potentially fatal form of acute necrotizing pancreatitis in which gas grows in and outside the pancreas, and typically involves the whole parenchyma in diabetic individuals.

Here we report an extremely rare case of a duodenal ulcer penetrating the pancreas and complicated with EP. Unlike the classic form of EP, which involves the whole parenchyma and has a poor prognosis, we found that the emphysematous involvement of the pancreas by PPU has a benign course if a conservative therapy is promptly established. Gas is confined to the site of penetration, usually the pancreatic head, and ulcers most often involve the duodenum.

• Acute
• Pancreatitis
• Emergency department
• Gas-forming bacteria

• Abdominal Pain/diagnostic imaging
• Abdominal Pain/etiology
• Abdominal Pain/therapy
• Conservative Treatment
• Contrast Media/administration & dosage
• Duodenal Ulcer/complications
• Emphysema/diagnostic imaging
• Emphysema/etiology
• Emphysema/therapy
• Humans
• Male
• Middle Aged
• Pancreas/diagnostic imaging
• Pancreas/pathology
• Pancreatitis, Acute Necrotizing/diagnostic imaging
• Pancreatitis, Acute Necrotizing/etiology
• Pancreatitis, Acute Necrotizing/therapy
• Peptic Ulcer Perforation/complications
• Tomography, X-Ray Computed/methods
• Treatment Outcome

• Cause
• Diagnosis
• EUS
• Elastography
• Gallstones
• Pancreas divisum
• Pancreatic function test
• Pancreatitis