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Almousa MA, Alnashwan YA, Amr SS. Perivascular Epithelioid Cell Tumor (PEComa) of the Pancreas in a Patient with Ulcerative Colitis: A Case Report and Review of the Literature. Healthcare (Basel) 2023; 11:healthcare11040547. [PMID: 36833081 PMCID: PMC9956215 DOI: 10.3390/healthcare11040547] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/31/2022] [Revised: 02/08/2023] [Accepted: 02/09/2023] [Indexed: 02/16/2023] Open
Abstract
Perivascular epithelioid cell tumors (PEComas) are mesenchymal tumors of peculiar cells that are focally associated with blood vessels, and generally have a distinctive bi-phenotypic expression of both smooth muscle and melanocytic markers. There are several entities in the PEComa family, including tumors that arise in the soft tissues and viscera. Frequently affected organs include the lungs (sugar tumors), uterus, broad ligament, colon, small bowel, liver, and pancreas. Ulcerative colitis (UC) has been associated with the development of tumors, especially colorectal and hepatobiliary carcinomas. Rare cases of UC have been reported in the PEComa family of tumors, but none in the pancreas. Here, we present a case study of a 27-year-old female patient with a history of UC who developed PEComa of the pancreas, a unique association that has not been previously reported. We also review reported cases of PEComas in the pancreas, as well as PEComas at all anatomic sites associated with UC.
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Affiliation(s)
- Maryam A. Almousa
- Department of Pathology and Laboratory Medicine, King Fahad Specialist Hospital, Dammam 34258, Saudi Arabia
| | - Yara A. Alnashwan
- Department of Pathology, College of Medicine, Imam Abdulrahman Bin Faisal University, Dammam 1982, Saudi Arabia
- Correspondence:
| | - Samir S. Amr
- Department of Pathology and Laboratory Medicine, Istishari Hospital, Amman 840431, Jordan
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Colón Rodríguez A, Calleja Kempin J, Quirós Higueras E, Ramón Botella E, Castillo J. Pancreatic perivascular epithelial cell tumour (PECOma). Case report and literature review. GASTROENTEROLOGIA Y HEPATOLOGIA 2020; 43:257-259. [PMID: 32249094 DOI: 10.1016/j.gastrohep.2019.11.012] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Received: 08/21/2019] [Revised: 10/19/2019] [Accepted: 11/17/2019] [Indexed: 02/07/2023]
Affiliation(s)
- Arturo Colón Rodríguez
- Servicio de Cirugía General y Aparato Digestivo, Hospital San Francisco de Asís, Madrid, España.
| | - Javier Calleja Kempin
- Servicio de Cirugía General y Aparato Digestivo, Hospital San Francisco de Asís, Madrid, España
| | - Esther Quirós Higueras
- Servicio de Cirugía General y Aparato Digestivo, Hospital San Francisco de Asís, Madrid, España
| | | | - Jorge Castillo
- Servicio de Anestesia y Reanimación, Hospital San Francisco de Asís, Madrid, España
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Uno K, Shimizu S, Hayashi K, Yamada T, Kusakabe A, Kanie H, Mizuno Y, Nagao K, Araki H, Toyohara T, Kanda T, Okayama K, Suzuki T, Miyagishima S, Watanabe T, Nakazawa T. Perivascular Epithelial Cell Tumor of the Pancreas Diagnosed Preoperatively by Endoscopic Ultrasound-guided Fine-needle Aspiration. Intern Med 2019; 58:2515-2521. [PMID: 31178480 PMCID: PMC6761333 DOI: 10.2169/internalmedicine.2265-18] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/06/2022] Open
Abstract
We herein report a 49-year-old woman with a perivascular epithelial cell tumor (PEComa) of the pancreas. Imaging studies demonstrated a relatively well-demarcated mass, measuring approximately 40 mm in diameter, located in the pancreatic tail. It was heterogeneously enhanced almost to the same degree as the surrounding pancreatic tissue in both the arterial and portal venous phases. We performed endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) using the Acquire® 22-gauge needle and preoperatively obtained a definitive diagnosis with a sufficient sample. Clinicians should consider pancreatic PEComa in their differential diagnosis of patients with a pancreatic mass.
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Affiliation(s)
- Konomu Uno
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Shuya Shimizu
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Katsumi Hayashi
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Tomonori Yamada
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Atsunori Kusakabe
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Hiroshi Kanie
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Yusuke Mizuno
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Kazuhiro Nagao
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Hiromichi Araki
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Tadashi Toyohara
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Takeo Kanda
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Kohei Okayama
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Takanori Suzuki
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Shun Miyagishima
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Takashi Watanabe
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
| | - Takahiro Nakazawa
- Department of Gastroenterology, Japanese Red Cross Nagoya Daini Hospital, Japan
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Zizzo M, Ugoletti L, Tumiati D, Castro Ruiz C, Bonacini S, Panebianco M, Sereni G, Manenti A, Lococo F, Carlinfante G, Pedrazzoli C. Primary pancreatic perivascular epithelioid cell tumor (PEComa): A surgical enigma. A systematic review of the literature. Pancreatology 2018; 18:238-245. [PMID: 29478828 DOI: 10.1016/j.pan.2018.02.007] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/03/2017] [Revised: 02/05/2018] [Accepted: 02/15/2018] [Indexed: 02/06/2023]
Abstract
BACKGROUND Perivascular epithelioid cell tumor (PEComa) is a rare mesenchymal tumor, with distinctive morphology and expression of myo-melanocytic markers. Current scientific literature reported just 24 cases of pancreatic PEComas. With our systematic review, we aimed at improving our understanding of the disease, focusing on the knowledge gained on epidemiology, etiology, clinical presentation, diagnosis, treatment and prognosis. METHODS Based on the PRISMA guidelines, a systematic research was carried out on PubMed/MEDLINE, Web of Science, Scopus, EMBASE, and EBSCO using the search terms: ("perivascular epithelioid cell tumor" OR ″PEComa") and ("pancreas "OR″ pancreatic"). RESULTS The 4th-6th decades of life and female sex (86.9%) turned out as the most affected. Pancreatic head was the most involved site (50%), with a single lesion in almost all cases. The diagnosis was only obtained after histopathological examination (70.8%). The clinical presentation was non-specific, abdominal pain being the main symptom (60.9%). At immunohistochemistry, PEComa showed benign epithelioid predominance and a strong positivity for HMB-45, Melan-A, and α-SMA. Surgical resection was performed in almost all cases, while for one patient the multidisciplinary group chose just endoscopic and imaging follow-up, based on the benign nature of the lesion. CONCLUSIONS The biological characteristics of pancreatic PEComa remain an enigma. Its prognosis seems to depend on whether atypical ("worrisome") histological features are available or not. Surgery turned out as the most appropriate treatment, without reaching any agreement on surgery timing. Further studies on larger population are needed to better understand the biological features of pancreatic PEComa, in order to set up guidelines in the diagnosis, treatment and follow-up.
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Affiliation(s)
- Maurizio Zizzo
- Department of Oncology and Advanced Technologies, Surgical Oncology Unit, IRCCS Arcispedale Santa Maria Nuova, Risorgimento Avenue 80, 42123 Reggio Emilia, Italy; Clinical and Experimental Medicine PhD Program, University of Modena and Reggio Emilia, Modena, Italy.
| | - Lara Ugoletti
- Department of Oncology and Advanced Technologies, Surgical Oncology Unit, IRCCS Arcispedale Santa Maria Nuova, Risorgimento Avenue 80, 42123 Reggio Emilia, Italy
| | - David Tumiati
- Department of Oncology and Advanced Technologies, Surgical Oncology Unit, IRCCS Arcispedale Santa Maria Nuova, Risorgimento Avenue 80, 42123 Reggio Emilia, Italy
| | - Carolina Castro Ruiz
- Department of Oncology and Advanced Technologies, Surgical Oncology Unit, IRCCS Arcispedale Santa Maria Nuova, Risorgimento Avenue 80, 42123 Reggio Emilia, Italy
| | - Stefano Bonacini
- Department of Oncology and Advanced Technologies, Surgical Oncology Unit, IRCCS Arcispedale Santa Maria Nuova, Risorgimento Avenue 80, 42123 Reggio Emilia, Italy
| | - Michele Panebianco
- Department of Oncology and Advanced Technologies, Oncology Unit, IRCCS Arcispedale Santa Maria Nuova, Risorgimento Avenue 80, 42123 Reggio Emilia, Italy
| | - Giuliana Sereni
- Department of Oncology and Advanced Technologies, Gastroenterology - Digestive Endoscopy Unit, IRCCS Arcispedale Santa Maria Nuova, Risorgimento Avenue 80, 42123 Reggio Emilia, Italy
| | - Antonio Manenti
- Department of General Surgery, Azienda Ospedaliero-Universitaria - Policlinico, Del Pozzo Street 71, 41124 Modena, Italy
| | - Filippo Lococo
- Department of Oncology and Advanced Technologies, Thoracic Surgery Unit, IRCCS Arcispedale Santa Maria Nuova, Risorgimento Avenue 80, 42123 Reggio Emilia, Italy
| | - Gabriele Carlinfante
- Department of Oncology and Advanced Technologies, Pathology Unit, IRCCS Arcispedale Santa Maria Nuova, Risorgimento Avenue 80, 42123 Reggio Emilia, Italy
| | - Claudio Pedrazzoli
- Department of Oncology and Advanced Technologies, Surgical Oncology Unit, IRCCS Arcispedale Santa Maria Nuova, Risorgimento Avenue 80, 42123 Reggio Emilia, Italy
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Abstract
There are a few entities that account for most solid and cystic masses of the pancreas. The pancreas harbors a wide array of diseases, including adenocarcinoma, and its variants, such as anaplastic and adenosquamous carcinoma. Other neoplasms include acinar cell carcinoma, solid pseudopapillary tumor, and sarcomas. Benign lesions include hamartomas, hemangiomas, lymphangioma, and plasmacytoma. Isolated metastases include renal cell carcinoma, melanoma, and other carcinomas. Benign inflammatory conditions, such as autoimmune pancreatitis and groove pancreatitis can also mimic solid neoplasms of the pancreas.
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Affiliation(s)
- John A Stauffer
- Department of Surgery, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, USA
| | - Horacio J Asbun
- Department of Surgery, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL 32224, USA.
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Zhang S, Chen F, Huang X, Jiang Q, Zhao Y, Chen Y, Zhang J, Ma J, Yuan W, Xu Q, Zhao J, Wang C. Perivascular epithelial cell tumor (PEComa) of the pancreas: A case report and review of literature. Medicine (Baltimore) 2017; 96:e7050. [PMID: 28562565 PMCID: PMC5459730 DOI: 10.1097/md.0000000000007050] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/13/2022] Open
Abstract
RATIONALE Perivascular epithelial cell tumors (PEComas) of the pancreas are rare mesenchymal tumors and, to our knowledge, only 20 cases have been reported to date. PATIENT CONCERNS We report a 43-year-old female who presented with upper abdominal pain for 1 year. She underwent an exploratory laparotomy at a local hospital, which failed to resect the tumor. Five months later, she came to the Chinese National Cancer Center for surgery. Preoperative imaging revealed an 11.5-cm-sized mass located in the head of the pancreas. At the microscopic level, the tumor was composed of epithelioid and spindle cells possessing clear to focally granular eosinophilic cytoplasm, which grew in a nested and alveolar pattern around blood vessels. The tumor cells showed immunoreactivity for human melanoma black 45 (HMB-45), but did not express epithelial or endocrine markers. DIAGNOSES Pancreatic PEComa. INTERVENTIONS Pancreaticoduodenectomy, partial hepatectomy, and vascular replacement were performed. After the surgery, the patient received 4 cycles of chemotherapy. OUTCOMES The patient is free of recurrence and metastasis 1.5 years after surgical resection. LESSONS PEComa should be recognized as a preoperative differential diagnosis of pancreatic tumors. For treatment, removal of the tumor should be attempted, and in the case of tumors with malignant tendencies, the addition of chemotherapy should be considered.
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Affiliation(s)
- Shuisheng Zhang
- Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
| | - Fang Chen
- Department of Oncology, Bozhou People's Hospital, Bozhou
| | - Xiaozhun Huang
- Department of Abdominal Surgery, Cancer Hospital of Chinese Academy of Medical Sciences, Shenzhen Center, Shenzhen Cancer Hospital, Shenzhen
| | - Qinglong Jiang
- Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
| | - Yajie Zhao
- Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
| | - Yingtai Chen
- Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
| | - Jianwei Zhang
- Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
| | - Jie Ma
- State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
| | - Wei Yuan
- State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
| | - Quan Xu
- Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
| | - Jiuda Zhao
- Department of Medical Oncology, Affiliated Hospital of Qinghai University, Xining, China
| | - Chengfeng Wang
- Department of Pancreatic and Gastric Surgery, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing
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Collins K, Buckley T, Anderson K, Karasik M, Ligato S. Perivascular Epithelioid Cell Tumor (PEComa) of Pancreas Diagnosed Preoperatively by Endoscopic Ultrasound-Guided Fine-Needle Aspiration. Diagn Cytopathol 2016; 45:59-65. [DOI: 10.1002/dc.23599] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/22/2016] [Revised: 08/16/2016] [Accepted: 08/22/2016] [Indexed: 12/20/2022]
Affiliation(s)
- Katrina Collins
- Department of Pathology; Hartford Hospital; Hartford Connecticut
| | - Tinera Buckley
- Department of Pathology; Hartford Hospital; Hartford Connecticut
| | - Kevin Anderson
- Department of Pathology; Beth Israel Deaconess Medical Center; Boston Massachusetts
| | - Michael Karasik
- Department of Gastroenterology; Hartford Hospital; Hartford Connecticut
| | - Saverio Ligato
- Department of Pathology; Hartford Hospital; Hartford Connecticut
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Perivascular epithelial cell tumor (PEComa) of the pancreas: a case report and review of previous literatures. Surg Case Rep 2016; 2:59. [PMID: 27307283 PMCID: PMC4909687 DOI: 10.1186/s40792-016-0186-x] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/05/2016] [Accepted: 06/09/2016] [Indexed: 12/28/2022] Open
Abstract
Perivascular epithelial cell tumors (PEComas), firstly described by Bonetti in 1992, are a family of mesenchymal tumor composed of perivascular epithelioid cells having epithelioid or spindle morphology and exhibiting melanocytic and myogenic immunoreactivities. We herein described a 61-year-old woman who presented with epigastric pain. Preoperative imaging studies showed that 7-cm-sized mass was located in pancreatic head and body, and pancreaticoduodenectomy was performed. Histological findings showed that the tumor was composed of clear epithelioid cells with abundant glycogen granules, which grew in a nested and alveolar pattern around blood vessels. The tumor cells showed immunoreactivities for HMB-45 but did not express epithelial or endocrine markers. These histological features indicated those of PEComa. This report underlines that we should recognize PEComa as a preoperative differential diagnosis of pancreatic tumors.
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Jiang H, Ta N, Huang XY, Zhang MH, Xu JJ, Zheng KL, Jin G, Zheng JM. Pancreatic perivascular epithelioid cell tumor: A case report with clinicopathological features and a literature review. World J Gastroenterol 2016; 22:3693-3700. [PMID: 27053862 PMCID: PMC4814656 DOI: 10.3748/wjg.v22.i13.3693] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/10/2015] [Revised: 12/27/2015] [Accepted: 01/11/2016] [Indexed: 02/06/2023] Open
Abstract
Perivascular epithelioid cell tumor (PEComa) of the pancreas is an unusual tumor deriving from mesenchyma. This paper described a case of pancreatic PEComa, which was initially suspected as neuroendocrine carcinoma by biopsy, and therefore surgical treatment was recommended due to undetermined diagnosis. Examination of the surgical specimen under a microscope showed that the tumor cell’s morphology was epithelioid or spindle-shaped, and ranged in a nested pattern. Additionally, these cells had a large extent of acidophilic cytoplasm, no mitotic figures, and expressed HMB-45, melan-p, and smooth muscle actin immunohistochemically. Pathological examination indicated that PEComa originated from the pancreas, but symptoms related to tuberous sclerosis were absent. Since PEComa is extremely rare in the pancreas, it is likely to be ignored in differential diagnosis. In conclusion, our article highlighted the clinicopathological features of PEComa, and we conducted a literature review focusing on PEComa so as to deepen the understanding of this tumor type.
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Manning MA, Srivastava A, Paal EE, Gould CF, Mortele KJ. Nonepithelial Neoplasms of the Pancreas: Radiologic-Pathologic Correlation, Part 1—Benign Tumors:From the Radiologic Pathology Archives. Radiographics 2016; 36:123-41. [DOI: 10.1148/rg.2016150212] [Citation(s) in RCA: 24] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/12/2022]
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Pancreatic perivascular epithelioid cell tumour presenting with upper gastrointestinal bleeding. Case Rep Oncol Med 2015; 2015:431215. [PMID: 25632358 PMCID: PMC4302363 DOI: 10.1155/2015/431215] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/13/2014] [Accepted: 12/29/2014] [Indexed: 01/02/2023] Open
Abstract
PEComa is a family of rare mesenchymal tumours which can occur in any part of the human body. Primary PEComas of the pancreas are extremely rare tumours with uncertain malignant potential. A 17-year-old female was admitted to the hospital due to melena. She required several transfusions. CT scan demonstrated a mass at the head of the pancreas measuring 4.2 cm in maximum diameter. An endoscopic ultrasound showed an ulcerating malignant looking mass infiltrating 50% of the wall of the second part of the duodenum in the region of the ampulla. Multiple biopsies taken showed extensive ulceration with granulation tissue formation and underlying large macrophages without being able to establish a definite diagnosis. We proceeded with pylorus-preserving pancreaticoduodenectomy. The postoperative course of the patient was unremarkable, and she was discharged on the 8th postoperative day. Histology examination of the specimen showed a PEComa of pancreas. Eighteen months after resection the patient is disease free. To the best of our knowledge this is the first time we describe a case of a pancreatic PEComa presenting with massive gastrointestinal bleeding.
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Okuwaki K, Kida M, Masutani H, Yamauchi H, Katagiri H, Mikami T, Miyazawa S, Iwai T, Takezawa M, Imaizumi H, Koizumi W. A resected perivascular epithelioid cell tumor (PEComa) of the pancreas diagnosed using endoscopic ultrasound-guided fine-needle aspiration. Intern Med 2013; 52:2061-6. [PMID: 24042513 DOI: 10.2169/internalmedicine.52.0746] [Citation(s) in RCA: 11] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/06/2022] Open
Abstract
Primary perivascular epithelioid cell tumors (PEComas) of the pancreas are extremely rare. We herein report our experience with a patient who had a primary PEComa of the pancreas that was diagnosed by the preoperative histopathological examination of a biopsy specimen obtained by endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). The patient was a 43-year-old woman whose chief complaint was abdominal pain. Imaging studies revealed a pancreatic tumor. Gastrointestinal stromal tumor (GIST), solid pseudopapillary tumor and neuroendocrine tumor were considered in the differential diagnosis. A histopathological examination of a specimen of the tumor obtained using EUS-FNA showed spindle-shaped tumor cells with enlarged nuclei and eosinophilic cytoplasm. The tumor cells proliferated in a sheet-like fashion and stained positive for the melanoma-associated antigen HMB-45. A PEComa was thus diagnosed. If an adequate tumor specimen can be obtained using EUS-FNA, immunostaining may facilitate the diagnosis of extremely rare diseases and therefore assist in deciding the treatment policy.
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Affiliation(s)
- Kosuke Okuwaki
- Department of Gastroenterology, Kitasato University School of Medicine, Japan
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Malignant PEComa of the lumbar vertebra: a rare bone tumour. Skeletal Radiol 2012; 41:1465-8. [PMID: 22584461 DOI: 10.1007/s00256-012-1411-8] [Citation(s) in RCA: 11] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/20/2011] [Revised: 03/07/2012] [Accepted: 03/29/2012] [Indexed: 02/02/2023]
Abstract
We describe the case of a 26-year-old patient with a perivascular epithelioid cell tumour (PEComa) involving the 5th lumbar vertebra. Radiological findings, pathological features and treatment are presented. We conclude that PEComas should be considered in the differential diagnosis of vertebral lesions.
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