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Fok KY, P’Ng CH, Mahajan H, Gosselink MP, El-Khoury T. Multiple caecal granular cell tumours-a case report. J Surg Case Rep 2021; 2021:rjab396. [PMID: 34567515 PMCID: PMC8458031 DOI: 10.1093/jscr/rjab396] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/19/2021] [Revised: 08/13/2021] [Accepted: 08/16/2021] [Indexed: 11/17/2022] Open
Abstract
Granular cell tumours (GCTs) are generally benign neoplasms, which are believed to be of neural origin. They are uncommon in the gastrointestinal tract. They are rarely found in the colon and even more rarely found to be multiple. We present a case of a man who underwent a right hemicolectomy for a submucosal lesion and polyps and was found to have multiple nodules diagnosed as caecal GCTs with cellular atypia. While uncommon, this case shows it remains an important differential due to implications for patient management, given the often benign nature of disease.
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Affiliation(s)
- Kar Yin Fok
- Correspondence address. Tel: +61-410-323-653; E-mail:
| | - Chow Heok P’Ng
- Department of Pathology, Westmead Hospital, Westmead, New South Wales, Australia
| | - Hema Mahajan
- Department of Pathology, Westmead Hospital, Westmead, New South Wales, Australia
| | | | - Toufic El-Khoury
- Department of Colorectal Surgery, Westmead Hospital, Westmead, New South Wales, Australia
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Granular Data: A Rare Submucosal Tumor of the Colon-Case Report and Review of the Literature. Dig Dis Sci 2021; 66:714-722. [PMID: 33433808 DOI: 10.1007/s10620-020-06753-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 11/23/2020] [Indexed: 12/09/2022]
Abstract
INTRODUCTION Granular cellular tumors are unusual lesions that can occur in the gastrointestinal tract, where they localize most commonly to the esophagus followed by the colon. AREAS COVERED We report a case of a young man with a sub-epithelial lesion of the ascending colon, removed by endoscopic submucosal dissection. Histological examination revealed a granular cellular tumor without features of malignancy. We present a systematic review of the English literature evaluating granular cellular tumors of lower gastrointestinal tract. EXPERT COMMENTARY These tumors are usually asymptomatic and discovered incidentally during endoscopy performed for other reasons. Though their histological behavior is usually benign, 1-2% are malignant. Therefore, it is important that these lesions are excised and adequately pathologically characterized.
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Gapp J, Gross J, Chintalacheruvu L, Reddymasu S. Coexisting Granular Cell Tumor and Tubular Adenoma of the Ileocecal Valve. Case Rep Gastroenterol 2018. [PMID: 29515339 PMCID: PMC5836207 DOI: 10.1159/000479496] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 01/22/2023] Open
Abstract
Granular cell tumors (GCTs) have been described as neoplasms of Schwann cell origin. They are often benign and notably uncommon in the gastrointestinal tract. Recently, their incidence has become more common, likely as a result of increased colonoscopy screenings. Very few data exist regarding their potential for malignancy, but malignant GCTs have been reported. Here, we report the case of a young female patient who was diagnosed with an atypical GCT on the ileocecal valve with an overlying tubular adenoma which was found incidentally on colonoscopy. This represents the first known report of a GCT with atypical features on the ileocecal valve, as well as a rare case of overlying adenomatous changes. Due to the paucity of cases, there is no clear modus operandi for their management. Furthermore, it is not clear whether surgical or endoscopic interventions or simple observation may be most appropriate. Further studies are needed to evaluate the potential for malignancy of this tumor, as well as its management.
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Affiliation(s)
- Jonathan Gapp
- Creighton University Medical Center, Omaha, Nebraska, USA
| | - John Gross
- Creighton University Medical Center, Omaha, Nebraska, USA
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4
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Schreiner P, Valli P, Marques Maggio E, Bauerfeind P. Simultaneous endoscopic full-thickness resection of two synchronous colonic granular cell tumours. BMJ Case Rep 2018; 2018:bcr-2017-222223. [PMID: 29391355 PMCID: PMC5812385 DOI: 10.1136/bcr-2017-222223] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 01/08/2018] [Indexed: 12/20/2022] Open
Abstract
Granular cell tumours (GCTs) are rare soft tissue tumours originating from Schwann cells. Due to potential malignant transformation, complete endoscopic resection should be aimed for. We report on a 49-year-old patient with two synchronous GCTs found in the caecum and the ascending colon, respectively. Synchronous endoscopic full-thickness resection (EFTR) using an all-in-one full-thickness resection device (FTRD) was performed under propofol sedation. Completeness of resection was proven histologically. No adverse events occurred. We report safe and complete simultaneous EFTR of two synchronous colonic GCTs.
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Affiliation(s)
- Philipp Schreiner
- Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland
| | - Piero Valli
- Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland
| | | | - Peter Bauerfeind
- Department of Gastroenterology and Hepatology, University Hospital Zurich, Zurich, Switzerland
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Mistrangelo M, Cassoni P, Scozzari G, Castellano I, Gavello G, Corno F, Morino M. Perianal Granular Cell Tumor: Report of a Case and Review of the Literature. TUMORI JOURNAL 2018; 95:538-41. [DOI: 10.1177/030089160909500424] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/17/2022]
Abstract
Introduction Granular cell tumor was first described by Abrikossoff in 1926. Over the years several cases of this neoplasm have been reported, with a variety of localizations. We here report a case of perianal granular cell tumor and discuss its histogenesis and its relevance to clinical practice. Methods The clinical course and histopathology of the case are reviewed, and a literature search for other reported cases has been performed. Results A 46-year-old woman presented with a perianal nodular lesion. Pathological examination revealed a granular cell tumor. A literature search produced only 25 other cases of anal and perianal granular cell tumors. Conclusions Granular cell tumors are rarely observed in the perianal region. Their existence must always be borne in mind in the differential diagnosis of perianal neoplasms. In most cases surgical excision is curative, but potential malignant transformation must be considered during therapeutic procedures and follow-up.
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Affiliation(s)
| | - Paola Cassoni
- Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
| | - Gitana Scozzari
- Department of Surgery and Center of Minimal Invasive Surgery, University of Turin, Italy
| | - Isabella Castellano
- Department of Biomedical Sciences and Human Oncology, University of Turin, Italy
| | - Giorgia Gavello
- Department of Surgery and Center of Minimal Invasive Surgery, University of Turin, Italy
| | - Franco Corno
- Department of Surgery and Center of Minimal Invasive Surgery, University of Turin, Italy
| | - Mario Morino
- Department of Surgery and Center of Minimal Invasive Surgery, University of Turin, Italy
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6
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Judd S, Antaki F. The "pot-of-gold" sign: not always a lipoma. Gastrointest Endosc 2014; 80:743-744. [PMID: 25220516 DOI: 10.1016/j.gie.2014.04.028] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/15/2014] [Accepted: 04/16/2014] [Indexed: 12/11/2022]
Affiliation(s)
- Stephanie Judd
- Division of Gastroenterology, Department of Internal Medicine, John D. Dingell VA Medical Center and Wayne State University School of Medicine, Detroit Medical Center, Detroit, Michigan, USA
| | - Fadi Antaki
- Division of Gastroenterology, Department of Internal Medicine, John D. Dingell VA Medical Center and Wayne State University School of Medicine, Detroit, Michigan, USA
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Tampaki EC, Nakopoulou L, Tampakis A, Kontzoglou K, Weber WP, Kouraklis G. Nestin involvement in tissue injury and cancer--a potential tumor marker? Cell Oncol (Dordr) 2014; 37:305-15. [PMID: 25164879 DOI: 10.1007/s13402-014-0193-5] [Citation(s) in RCA: 21] [Impact Index Per Article: 1.9] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 07/30/2014] [Indexed: 12/20/2022] Open
Abstract
BACKGROUND In eukaryotic cells, the cytoskeleton contains three major filamentous components: actin microfilaments, microtubules and intermediate filaments. Nestin represents one of the class VI intermediate filament proteins. Clinical and molecular analyses have revealed substantial information regarding the presence of Nestin in cells with progenitor or stem cell properties. During tissue injury Nestin is expressed in cells with progenitor cell-like properties. These cells may serve as a tissue reserve and, as such, may contribute to tissue repair. Based on currently available data, Nestin also appears to be implicated in two oncogenic processes. First, Nestin has been found to be expressed in cancer stem-like cells and poorly differentiated cancer cells and, as such, Nestin is thought to contribute to the aggressive behavior of these cells. Second, Nestin has been found to be involved in tumor angiogenesis through an interaction of cancer cells and blood vessel endothelial cells and, as such, Nestin is thought to facilitate tumor growth. CONCLUSIONS We conclude that Nestin may serve as a promising tumor marker and as a potential therapeutic target amenable to tumor suppression and angiogenesis inhibition.
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Affiliation(s)
- Ekaterini Christina Tampaki
- 2nd Department of Propedeutic Surgery, Athens University Medical School, Laiko General Hospital, 17 Agiou Thoma Street, 11527, Athens, Greece,
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8
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Na JI, Kim HJ, Jung JJ, Kim Y, Kim SS, Lee JH, Lee KH, Park JT. Granular cell tumours of the colorectum: histopathological and immunohistochemical evaluation of 30 cases. Histopathology 2014; 65:764-74. [DOI: 10.1111/his.12487] [Citation(s) in RCA: 20] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/25/2014] [Accepted: 06/23/2014] [Indexed: 11/30/2022]
Affiliation(s)
- Jong-In Na
- Department of Pathology; Chonnam National University Medical School; Gwangju Korea
| | - Hye-Jeong Kim
- Department of Pathology; Chonnam National University Medical School; Gwangju Korea
| | - Jong-Jae Jung
- Department of Pathology; Chonnam National University Medical School; Gwangju Korea
| | - Young Kim
- Department of Pathology; Chonnam National University Medical School; Gwangju Korea
| | - Sung-Sun Kim
- Department of Pathology; Chonnam National University Medical School; Gwangju Korea
| | - Jae-Hyuk Lee
- Department of Pathology; Chonnam National University Medical School; Gwangju Korea
| | - Kyung-Hwa Lee
- Department of Pathology; Chonnam National University Medical School; Gwangju Korea
| | - Jong-Tae Park
- Department of Forensic Medicine; Chonnam National University Medical School; Gwangju Korea
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9
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Recurrent granular cell tumor of the anal-perianal region: how much anal sphincter can be resected? Tech Coloproctol 2013; 18:597-600. [PMID: 23856985 DOI: 10.1007/s10151-013-1043-6] [Citation(s) in RCA: 3] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/03/2013] [Accepted: 06/13/2013] [Indexed: 10/26/2022]
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Abstract
CONTEXT A significant portion of colorectal biopsies are performed for evaluation of polyps or polypoid lesions. Accurately identifying these lesions will promote better patient care. OBJECTIVE Review of the pathology of major colon polyps and polypoid lesions and highlight the most diagnostically useful features and their molecular biology. DATA SOURCE Review of recent literature. CONCLUSIONS Polypoid lesions of the colon can be thought of to be under 3 broad categories: syndromic, mesenchymal, and epithelial.
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Affiliation(s)
- Sharmeen Mansoor
- Department of Pathology, Danbury Hospital, 2 Tower Lab, 24 Hospital Avenue, Danbury, CT 06810, USA
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11
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Zoccali M, Cipriani N, Fichera A, Turner JR, Krane M. Acute appendicitis secondary to a granular cell tumor of the appendix in a 19-year-old male. J Gastrointest Surg 2011; 15:1482-5. [PMID: 21533589 DOI: 10.1007/s11605-011-1536-4] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/25/2011] [Accepted: 04/04/2011] [Indexed: 01/31/2023]
Abstract
INTRODUCTION Granular cell tumors are rare, usually benign, neoplasms presenting as solitary small nodules in the skin or subcutaneous tissue. Involvement of the gastrointestinal tract is unusual, particularly of the appendix, and it is characterized by indolent, submucosal lesions usually diagnosed as an incidental finding. CASE REPORT We describe the rare case of acute appendicitis secondary to a granular cell tumor of the appendix in a 19-year-old male.
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Affiliation(s)
- Marco Zoccali
- Department of Surgery, University of Chicago Medical Center, Chicago, IL, 60637, USA.
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Cha JM, Lee JI, Joo KR, Choe JW, Jung SW, Shin HP, Lim SJ. Granular cell tumor of the descending colon treated by endoscopic mucosal resection: a case report and review of the literature. J Korean Med Sci 2009; 24:337-41. [PMID: 19399282 PMCID: PMC2672140 DOI: 10.3346/jkms.2009.24.2.337] [Citation(s) in RCA: 13] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/28/2007] [Accepted: 01/29/2008] [Indexed: 01/02/2023] Open
Abstract
Although colorectal granular cell tumors (GCTs) are rare, their incidental finding has increased as the use of diagnostic colonoscopy has become more common. Here we describe the case of a 41-yr-old man with a GCT in the descending colon that was detected after a screening colonoscopy. Endoscopic examination revealed a yellowish submucosal tumor, 13x12 mm in diameter, in the descending colon. Endoscopic mucosal resection (EMR) followed by histological examination revealed that the tumor was composed of plump histiocyte-like cells with an abundant granular eosinophilic cytoplasm and small round nuclei. The tumor cells expressed S-100 protein and stained with periodic acid-Schiff, but were negative for desmin and cytokeratin. The resected tumor was diagnosed as a GCT. Colonoscopists should consider the possibility of GCT in the differential diagnosis of yellowish submucosal tumors of the colon. In such patients, EMR seems to be a feasible and safe approach for diagnosis and treatment.
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Affiliation(s)
- Jae Myung Cha
- Department of Internal Medicine, Kyunghee University College of Medicine, Seoul, Korea
| | - Joung Il Lee
- Department of Internal Medicine, Kyunghee University College of Medicine, Seoul, Korea
| | - Kwang Ro Joo
- Department of Internal Medicine, Kyunghee University College of Medicine, Seoul, Korea
| | - Jae Won Choe
- Department of Internal Medicine, Kyunghee University College of Medicine, Seoul, Korea
| | - Sung Won Jung
- Department of Internal Medicine, Kyunghee University College of Medicine, Seoul, Korea
| | - Hyun Phil Shin
- Department of Internal Medicine, Kyunghee University College of Medicine, Seoul, Korea
| | - Sung Jik Lim
- Department of Pathology, Kyunghee University College of Medicine, Seoul, Korea
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14
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Ponsaing LG, Kiss K, Loft A, Jensen LI, Hansen MB. Diagnostic procedures for submucosal tumors in the gastrointestinal tract. World J Gastroenterol 2007; 13:3301-10. [PMID: 17659668 PMCID: PMC4172709 DOI: 10.3748/wjg.v13.i24.3301] [Citation(s) in RCA: 54] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/06/2023] Open
Abstract
This review is part one of three, which will present an update on diagnostic procedures for gastrointestinal (GI) submucosal tumors (SMTs). Part two identifies the classification and part three the therapeutic methods regarding GI SMTs. Submucosal tumors are typically asymptomatic and therefore encountered incidentally. Advances in diagnostic tools for gastrointestinal submucosal tumors have emerged over the past decade. The aim of this paper is to provide the readers with guidelines for the use of diagnostic procedures, when a submucosal tumor is suspected. Literature searches were performed to find information on diagnostics for gastrointestinal submucosal tumors. Based on the searches, the optimal diagnostic procedures and specific features of the submucosal tumors could be outlined. Standard endoscppy, capsule endoscopy and push-and-pull enteroscopy (PPE) together with barium contrast X-ray do not alone provide sufficient information, when examining submucosal tumors. Endoscopic ultrasound (EUS), computed tomography (CT), magnetic resonance imaging (MRI) and fluorodeoxyglucose-labeled positron emission tomography (FDG-PET) are recommended as supplementary tools.
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Affiliation(s)
- Laura-Graves Ponsaing
- Department of Surgical Gastroenterology K, Bispebjerg University Hospital of Copenhagen, Bispebjerg Bakke 23, 2400 NV Copenhagen, Denmark.
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McIntire M, Jakate S, Losurdo J. Granular cell tumor in colonic polyp found on screening colonoscopy. Clin Gastroenterol Hepatol 2007; 5:e17-8. [PMID: 17428738 DOI: 10.1016/j.cgh.2007.01.010] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/07/2023]
Affiliation(s)
- Maria McIntire
- Department of Pathology, Rush University Medical Center, Chicago, Illinois, USA
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Núñez Hospital D, Sánchez Muñoz D, Schmidt Baumler A, Pinto Morales W, Ramírez Martín del Campo M, García Romero D, Pérez Pastor A, Guerrero Jiménez P, Grande Santamaría L, Miralles Sanchis EJ, Romero Gómez M. Tumor de células granulares cecal y enfermedad de crohn. GASTROENTEROLOGIA Y HEPATOLOGIA 2007; 30:315-6. [PMID: 17493442 DOI: 10.1157/13101983] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/21/2022]
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Lowe DL, Chaudhary AJ, Lee JR, Chamberlain SM, Schade RR, Cuartas-Hoyos U. Four cases of patients with gastrointestinal granular cell tumors. South Med J 2007; 100:298-300. [PMID: 17396735 DOI: 10.1097/smj.0b013e318030eeff] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [MESH Headings] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/26/2022]
Abstract
We present four cases of gastrointestinal granular cell tumors (GCT) with a literature review. Gastrointestinal granular cell tumors, a benign neural tumor thought to arise from Schwann cells, can occur in several areas, including the gastrointestinal tract. Studies suggest that endoscopic ultrasound and endoscopic removal is the treatment of choice for esophageal GCTs if they are small in size (< 2 cm) and do not involve the muscularis propria. GCTs are malignant less than 2% of the time. Although most GCTs are benign and can be followed endoscopically without resection, the malignant potential warrants evaluation with endoscopic ultrasound for possible endoscopic or surgical resection.
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Affiliation(s)
- Douglas L Lowe
- Department of Internal Medicine, Section of Gastroenterology/Hepatology, Medical College of Georgia 1120 15th Street, BBR2538, Augusta, GA 30912-3120, USA
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Sharma S, Gupta M. A colonic polyp due to Langerhans cell histiocytosis: a lesion not to be confused with metastatic malignant melanoma. Histopathology 2006; 49:438-9. [PMID: 16978213 DOI: 10.1111/j.1365-2559.2006.02463.x] [Citation(s) in RCA: 14] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/17/2023]
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Parfitt JR, McLean CA, Joseph MG, Streutker CJ, Al-Haddad S, Driman DK. Granular cell tumours of the gastrointestinal tract: expression of nestin and clinicopathological evaluation of 11 patients. Histopathology 2006; 48:424-30. [PMID: 16487364 DOI: 10.1111/j.1365-2559.2006.02352.x] [Citation(s) in RCA: 56] [Impact Index Per Article: 2.9] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/16/2022]
Abstract
AIMS Granular cell tumours (GCTs) in the gastrointestinal (GI) tract are rare, with few series reported in the literature. Nestin is a recently identified intermediate filament protein that is expressed in neuroectodermal stem cells and skeletal muscle progenitor cells and has been shown to be expressed in gastrointestinal stromal tumours (GISTs) and GI schwannomas. Herein, we describe the clinicopathological and immunohistochemical features of 11 GI GCTs, introducing nestin as an additional marker that identifies these tumours. METHODS AND RESULTS The archives of the departments of pathology at London Health Sciences Centre (London, Ontario) and St Michael's Hospital (Toronto, Ontario) were searched for GCTs occurring in the GI tract, yielding 11 cases. Histological features were assessed and immunohistochemistry was performed with S100 protein, nestin, glial fibrillary acidic protein (GFAP), CD34, desmin, CD117, and inhibin-alpha. Charts were reviewed for clinical information. Ages at diagnosis ranged from 31 to 73 years; there were six males and four females. All GCTs were solitary, six in the oesophagus, three in the caecum, one in the rectum and one perianal. Most lesions were discovered incidentally. The size of the GCTs ranged from 4 mm to 30 mm. All were submucosal, typically firm, with a white-yellow appearance. Histologically, the GCTs showed moderate cellularity, predominantly solid growth with areas of nesting. While lesional cells were mainly plump and polygonal, areas of spindling were present in several tumours, more frequently in the colorectum. Margins were circumscribed. Nuclei were round to oval, with even chromatin and small nucleoli. Mitoses were rare to absent and necrosis was absent in all cases. Staining with periodic acid-Schiff, with diastase predigestion, showed globular and diffuse positivity within the cytoplasm. Moderate to strong expression of S100 protein and nestin was observed in 11 of 11 and seven of seven tumours, respectively. GFAP, CD34, desmin, CD117 and inhibin-alpha were negative. While patients were variably managed with resection or observation, all remain clinically well, without disease progression. CONCLUSIONS Although rare, GI GCTs have characteristic clinicopathological features. Nestin may be a useful immunohistochemical marker for identifying these tumours; the presence of this persistent stem cell cytoskeletal filament within GI GCTs suggests that these lesions may arise from a multipotential stem cell in the GI tract.
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Affiliation(s)
- J R Parfitt
- Department of Pathology, London Health Sciences Centre, University of Western Ontario, London, Canada
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Sohn DK, Choi HS, Chang YS, Huh JM, Kim DH, Kim DY, Kim YH, Chang HJ, Jung KH, Jeong SY. Granular cell tumor of colon: Report of a case and review of literature. World J Gastroenterol 2004; 10:2452-4. [PMID: 15285042 PMCID: PMC4576310 DOI: 10.3748/wjg.v10.i16.2452] [Citation(s) in RCA: 28] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/15/2022] Open
Abstract
Granular cell tumor (GCT) is uncommon in the colon and rectum. Here we report a case of GCT in the transverse colon. A 48-year-old male patient underwent a screening colonoscopy. A yellowish sessile lesion, about 4 mm in diameter, was found in the transverse colon. An endoscopic snare resection was performed without complication. Histological examination revealed the tumor consisted of plump neoplastic cells with abundant granular eosinophilic cytoplasm containing acidophilic periodic acid Schiff-positive, diastase-resistant granules. Immunohistochemical analysis showed the tumor cells expressed S-100 protein and neuron-specific enolase. Thus, the resected tumor was diagnosed as a GCT. Since GCTs are usually benign, endoscopic resection constitutes an easy and safe treatment. Colonoscopists should consider the possibility of GCT in the differential diagnosis of submucosal tumors of the colon.
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Affiliation(s)
- Dae-Kyung Sohn
- Center for Colorectal Cancer, Research Institute and Hospital, National Cancer Center, 809 Madu-dong, Ilsan-gu, Goyang, Gyeonggi 411-769, Korea
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