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Andersson U, Wibom C, Cederquist K, Aradottir S, Borg A, Armstrong GN, Shete S, Lau CC, Bainbridge MN, Claus EB, Barnholtz-Sloan J, Lai R, Il'yasova D, Houlston RS, Schildkraut J, Bernstein JL, Olson SH, Jenkins RB, Lachance DH, Wrensch M, Davis FG, Merrell R, Johansen C, Sadetzki S, Bondy ML, Melin BS. Germline rearrangements in families with strong family history of glioma and malignant melanoma, colon, and breast cancer. Neuro Oncol 2014; 16:1333-40. [PMID: 24723567 PMCID: PMC4165415 DOI: 10.1093/neuonc/nou052] [Citation(s) in RCA: 9] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/14/2013] [Accepted: 03/10/2014] [Indexed: 12/18/2022] Open
Abstract
BACKGROUND Although familial susceptibility to glioma is known, the genetic basis for this susceptibility remains unidentified in the majority of glioma-specific families. An alternative approach to identifying such genes is to examine cancer pedigrees, which include glioma as one of several cancer phenotypes, to determine whether common chromosomal modifications might account for the familial aggregation of glioma and other cancers. METHODS Germline rearrangements in 146 glioma families (from the Gliogene Consortium; http://www.gliogene.org/) were examined using multiplex ligation-dependent probe amplification. These families all had at least 2 verified glioma cases and a third reported or verified glioma case in the same family or 2 glioma cases in the family with at least one family member affected with melanoma, colon, or breast cancer.The genomic areas covering TP53, CDKN2A, MLH1, and MSH2 were selected because these genes have been previously reported to be associated with cancer pedigrees known to include glioma. RESULTS We detected a single structural rearrangement, a deletion of exons 1-6 in MSH2, in the proband of one family with 3 cases with glioma and one relative with colon cancer. CONCLUSIONS Large deletions and duplications are rare events in familial glioma cases, even in families with a strong family history of cancers that may be involved in known cancer syndromes.
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Affiliation(s)
- Ulrika Andersson
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Carl Wibom
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Kristina Cederquist
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Steina Aradottir
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Ake Borg
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Georgina N Armstrong
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Sanjay Shete
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Ching C Lau
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Matthew N Bainbridge
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Elizabeth B Claus
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Jill Barnholtz-Sloan
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Rose Lai
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Dora Il'yasova
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Richard S Houlston
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Joellen Schildkraut
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Jonine L Bernstein
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Sara H Olson
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Robert B Jenkins
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Daniel H Lachance
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Margaret Wrensch
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Faith G Davis
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Ryan Merrell
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Christoffer Johansen
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Siegal Sadetzki
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Melissa L Bondy
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
| | - Beatrice S Melin
- Department of Radiation Sciences, Oncology, Umeå University, Umeå, Sweden (U.A., C.W., B.S.M.); Computational Life Science Cluster (CLiC), Umeå University, Umeå, Sweden (C.W.); Department of Medical Biosciences, Pathology, Umeå University, Umeå Sweden (K.C.); Department of Oncology, Clinical Science, Lund University, Lund, Sweden (S.A., Å.B.); Department of Pediatrics, Section of Hematology/Oncology, Baylor College of Medicine, Houston, Texas (G.N.A., M.L.B.); Department of Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas (S.S.); Texas Children's Cancer and Hematology Centers, Baylor College of Medicine, Houston, Texas (C.C.L.); Human Genome Sequencing Center, Baylor College of Medicine, Houston, Texas (M.N.B.); School of Public Health, Yale University, New Haven, Connecticut (E.B.C.); Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts (E.B.C.); Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio (J.B.-S.); University of Southern California, Los Angeles, California (R.L.); Cancer Control and Prevention Program/Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina (D.I., J.S.); Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK (R.S.H.); Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center , New York, New York (J.L.B., S.H.O.); Mayo Comprehensive Clinic Cancer, Mayo Clinic, Rochester, Minnesota (R.B.J., D.H.L.); Department of Neurological Surgery, University of California, San Francisco, California (M.W.); School of Public Health, University of Alberta, Edmonton, Canada (F.G.D.); Department of Neurology, NorthShore University Health System, Evanston, Illinois (R.M.); Cancer Late Effects Research, Oncology, Finsencenteret, Rigshospitalet, University of Copenhagen and Head, Survivorship, Danish Cancer Society Research Center, Copenhagen, Denmark (C.J.)
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