Reference Citation Analysis: Find an Article, Find a Category, Find a Journal, Find a Scholar

For: Kudo SE, Wakamura K, Ikehara N, Mori Y, Inoue H, Hamatani S. Diagnosis of colorectal lesions with a novel endocytoscopic classification - a pilot study. Endoscopy 2011;43:869-75. [PMID: 21837586 DOI: 10.1055/s-0030-1256663] [Citation(s) in RCA: 97] [Impact Index Per Article: 6.9] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/07/2023]

For:	Kudo SE, Wakamura K, Ikehara N, Mori Y, Inoue H, Hamatani S. Diagnosis of colorectal lesions with a novel endocytoscopic classification - a pilot study. Endoscopy 2011;43:869-75. [PMID: 21837586 DOI: 10.1055/s-0030-1256663] [Citation(s) in RCA: 97] [Impact Index Per Article: 6.9] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/07/2023]

Number

Cited by Other Article(s)

Okumura T, Hotta K, Aizawa D, Imai K, Ito S, Takada K, Shimoda T, Ono H. Real-time diagnosis of a lesion of the anal canal observed by endocytoscopy. Clin J Gastroenterol 2025;18:95-99. [PMID: 39760965 DOI: 10.1007/s12328-024-02073-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/04/2024] [Accepted: 11/18/2024] [Indexed: 01/07/2025]

Jans A, Sinonquel P, Bisschops R. Advanced Endoscopic Imaging for Dysplasia Characterization in Inflammatory Bowel Disease. Gastrointest Endosc Clin N Am 2025;35:179-194. [PMID: 39510686 DOI: 10.1016/j.giec.2024.07.006] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/15/2024]

Cheng Y, Li L, Bi Y, Su S, Zhang B, Feng X, Wang N, Zhang W, Yao Y, Ru N, Xiang J, Sun L, Hu K, Wen F, Wang Z, Bai L, Wang X, Wang R, Lv X, Wang P, Meng F, Xiao W, Linghu E, Chai N. Computer-aided diagnosis system for optical diagnosis of colorectal polyps under white light imaging. Dig Liver Dis 2024;56:1738-1745. [PMID: 38744557 DOI: 10.1016/j.dld.2024.04.023] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/31/2023] [Revised: 03/21/2024] [Accepted: 04/23/2024] [Indexed: 05/16/2024]

Affiliation(s)

Yaxuan Cheng Chinese PLA Medical School, Beijing, 100853, PR China; Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Longsong Li Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Yawei Bi Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Song Su Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Bo Zhang Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Xiuxue Feng Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Nanjun Wang Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Wengang Zhang Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Yi Yao Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Nan Ru Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Jingyuan Xiang Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Lihua Sun Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Kang Hu Department of Gastroenterology, The 987 Hospital of PLA Joint Logistic Support Force, Baoji, 721004, PR China
Feng Wen Department of Gastroenterology, General Hospital of Central Theater Command of PLA,Wuhan 430070, PR China
Zixin Wang Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Lu Bai Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Xueting Wang Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Runzi Wang Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Xingping Lv Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Pengju Wang Chinese PLA Medical School, Beijing, 100853, PR China; Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China
Fanqi Meng Medical Department, HighWise Medical Technology Co, Ltd, Changsha, 410000, PR China
Wen Xiao Medical Department, HighWise Medical Technology Co, Ltd, Changsha, 410000, PR China
Enqiang Linghu Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China.
Ningli Chai Department of Gastroenterology, The First Medical Center of Chinese PLA General Hospital, Beijing, 100853, PR China.

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Mandarino FV, Danese S, Uraoka T, Parra-Blanco A, Maeda Y, Saito Y, Kudo SE, Bourke MJ, Iacucci M. Precision endoscopy in colorectal polyps' characterization and planning of endoscopic therapy. Dig Endosc 2024;36:761-777. [PMID: 37988279 DOI: 10.1111/den.14727] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/25/2023] [Accepted: 11/19/2023] [Indexed: 11/23/2023]

Canakis A, Bomman S, Twery B, Varghese N, Ji B, Canakis J, Goldberg EM. The diagnostic utility of endocytoscopy for the detection of gastric cancer: a systematic review and meta-analysis. Minerva Gastroenterol (Torino) 2024;70:225-230. [PMID: 35511654 DOI: 10.23736/s2724-5985.22.03172-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/08/2022]

Suzuki K, Kudo S, Kudo T, Misawa M, Mori Y, Ichimasa K, Maeda Y, Hayashi T, Wakamura K, Baba T, Ishda F, Hamatani S, Inoue H, Yokoyama K, Miyachi H. Diagnostic performance of endocytoscopy with normal pit-like structure sign for colorectal low-grade adenoma compared with conventional modalities. DEN OPEN 2024;4:e238. [PMID: 37168271 PMCID: PMC10165464 DOI: 10.1002/deo2.238] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 11/23/2022] [Revised: 02/28/2023] [Accepted: 04/03/2023] [Indexed: 05/13/2023]

Khalaf K, Fujiyoshi MRA, Spadaccini M, Rizkala T, Ramai D, Colombo M, Fugazza A, Facciorusso A, Carrara S, Hassan C, Repici A. From Staining Techniques to Artificial Intelligence: A Review of Colorectal Polyps Characterization. MEDICINA (KAUNAS, LITHUANIA) 2024;60:89. [PMID: 38256350 PMCID: PMC10818333 DOI: 10.3390/medicina60010089] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/16/2023] [Revised: 12/24/2023] [Accepted: 12/26/2023] [Indexed: 01/24/2024]

Affiliation(s)

Kareem Khalaf Division of Gastroenterology, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1T8, Canada; (K.K.); (M.R.A.F.)
Mary Raina Angeli Fujiyoshi Division of Gastroenterology, St. Michael’s Hospital, University of Toronto, Toronto, ON M5B 1T8, Canada; (K.K.); (M.R.A.F.) Digestive Diseases Center, Showa University Koto Toyosu Hospital, Tokyo 135-8577, Japan
Marco Spadaccini Department of Endoscopy, Humanitas Research Hospital, IRCCS, 20089 Rozzano, Italy; (T.R.); (M.C.); (A.F.); (S.C.); (C.H.); (A.R.) Department of Biomedical Sciences, Humanitas University, 20089 Rozzano, Italy
Tommy Rizkala Department of Endoscopy, Humanitas Research Hospital, IRCCS, 20089 Rozzano, Italy; (T.R.); (M.C.); (A.F.); (S.C.); (C.H.); (A.R.) Department of Biomedical Sciences, Humanitas University, 20089 Rozzano, Italy
Daryl Ramai Gastroenterology and Hepatology, University of Utah Health, Salt Lake City, UT 84132, USA;
Matteo Colombo Department of Endoscopy, Humanitas Research Hospital, IRCCS, 20089 Rozzano, Italy; (T.R.); (M.C.); (A.F.); (S.C.); (C.H.); (A.R.)
Alessandro Fugazza Department of Endoscopy, Humanitas Research Hospital, IRCCS, 20089 Rozzano, Italy; (T.R.); (M.C.); (A.F.); (S.C.); (C.H.); (A.R.)
Antonio Facciorusso Department of Endoscopy, Section of Gastroenterology, Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy;
Silvia Carrara Department of Endoscopy, Humanitas Research Hospital, IRCCS, 20089 Rozzano, Italy; (T.R.); (M.C.); (A.F.); (S.C.); (C.H.); (A.R.)
Cesare Hassan Department of Endoscopy, Humanitas Research Hospital, IRCCS, 20089 Rozzano, Italy; (T.R.); (M.C.); (A.F.); (S.C.); (C.H.); (A.R.) Department of Biomedical Sciences, Humanitas University, 20089 Rozzano, Italy
Alessandro Repici Department of Endoscopy, Humanitas Research Hospital, IRCCS, 20089 Rozzano, Italy; (T.R.); (M.C.); (A.F.); (S.C.); (C.H.); (A.R.) Department of Biomedical Sciences, Humanitas University, 20089 Rozzano, Italy

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Zhang H, Yang X, Tao Y, Zhang X, Huang X. Diagnostic accuracy of endocytoscopy via artificial intelligence in colorectal lesions: A systematic review and meta‑analysis. PLoS One 2023;18:e0294930. [PMID: 38113199 PMCID: PMC10729963 DOI: 10.1371/journal.pone.0294930] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/06/2023] [Accepted: 11/10/2023] [Indexed: 12/21/2023] Open

Abstract

BACKGROUND

Endocytoscopy (EC) is a nuclei and micro-vessels visualization in real-time and can facilitate "optical biopsy" and "virtual histology" of colorectal lesions. This study aimed to investigate the significance of employing artificial intelligence (AI) in the field of endoscopy, specifically in diagnosing colorectal lesions. The research was conducted under the supervision of experienced professionals and trainees.

METHODS

EMBASE, PubMed, Cochrane Library, Web of Science, Chinese National Knowledge Infrastructure (CNKI) database, and other potential databases were surveyed for articles related to the EC with AI published before September 2023. RevMan (5.40), Stata (14.0), and R software (4.1.0) were used for statistical assessment. Studies that measured the accuracy of EC using AI for colorectal lesions were included. Two authors independently assessed the selected studies and their extracted data. This included information such as the country, literature, total study population, study design, characteristics of the fundamental study and control groups, sensitivity, number of samples, assay methodology, specificity, true positives or negatives, and false positives or negatives. The diagnostic accuracy of EC by AI was determined by a bivariate random-effects model, avoiding a high heterogeneity effect. The ANOVA model was employed to determine the more effective approach.

RESULTS

A total of 223 studies were reviewed; 8 articles were selected that included 2984 patients (4241 lesions) for systematic review and meta-analysis. AI assessed 4069 lesions; experts diagnosed 3165 and 5014 by trainees. AI demonstrated high accuracy, sensitivity, and specificity levels in detecting colorectal lesions, with values of 0.93 (95% CI: 0.90, 0.95) and 0.94 (95% CI: 0.73, 0.99). Expert diagnosis was 0.90 (95% CI: 0.85, 0.94), 0.87 (95% CI: 0.78, 0.93), and trainee diagnosis was 0.74 (95% CI: 0.67, 0.79), 0.72 (95% CI: 0.62, 0.80). With the EC by AI, the AUC from SROC was 0.95 (95% CI: 0.93, 0.97), therefore classified as excellent category, expert showed 0.95 (95% CI: 0.93, 0.97), and the trainee had 0.79 (95% CI: 0.75, 0.82). The superior index from the ANOVA model was 4.00 (1.15,5.00), 2.00 (1.15,5.00), and 0.20 (0.20,0.20), respectively. The examiners conducted meta-regression and subgroup analyses to evaluate the presence of heterogeneity. The findings of these investigations suggest that the utilization of NBI technology was correlated with variability in sensitivity and specificity. There was a lack of solid evidence indicating the presence of publishing bias.

CONCLUSIONS

The present findings indicate that using AI in EC can potentially enhance the efficiency of diagnosing colorectal abnormalities. As a valuable instrument, it can enhance prognostic outcomes in ordinary EC procedures, exhibiting superior diagnostic accuracy compared to trainee-level endoscopists and demonstrating comparability to expert endoscopists. The research is subject to certain constraints, namely a limited number of clinical investigations and variations in the methodologies used for identification. Consequently, it is imperative to conduct comprehensive and extensive research to enhance the precision of diagnostic procedures.

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Hirata S, Toyoshima N, Takamaru H, Yamada M, Kobayashi N, Kozu T, Saito Y. Underwater endoscopic mucosal resection with submucosal injection. Endoscopy 2023;55:E70-E71. [PMID: 36179711 PMCID: PMC9829822 DOI: 10.1055/a-1930-6373] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 01/13/2023]

Cassinotti A, Parravicini M, Chapman TP, Balzarini M, Canova L, Segato S, Zadro V, Travis S, Segato S. Endoscopic characterization of neoplastic and non-neoplastic lesions in inflammatory bowel disease: systematic review in the era of advanced endoscopic imaging. Therap Adv Gastroenterol 2023;16:17562848231208667. [PMID: 37954537 PMCID: PMC10638882 DOI: 10.1177/17562848231208667] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/14/2023] [Accepted: 10/03/2023] [Indexed: 11/14/2023] Open

Abstract

Background

Current guidelines strongly recommend the use of validated classifications to support optical diagnosis of lesions with advanced endoscopic imaging in the lower gastrointestinal tract. However, the optimal strategy in inflammatory bowel disease (IBD) is still a matter of debate.

Objectives

To analyze the accuracy of endoscopic classifications or single predictors for in vivo lesion characterization during endoscopic surveillance of IBD with advanced endoscopic imaging.

Design

Systematic review.

Data sources and methods

Medline and PubMed were used to extract all studies which focused on lesion characterization of neoplastic and non-neoplastic lesions in IBD. The diagnostic accuracy of endoscopic classifications and single endoscopic predictors for lesion characterization were analyzed according to type of patients, lesions, and technology used. When available, the rates of true and false positives or negatives for neoplasia were pooled and the sensitivity (SE), specificity (SP), positive predictive value, and negative predictive value (NPV) were calculated.

Results

We included 35 studies (2789 patients; 5925 lesions - 1149 neoplastic). Advanced endoscopic imaging included dye-based chromoendoscopy, virtual chromoendoscopy (VCE), magnification and high-definition endoscopy, confocal laser endomicroscopy (CLE), endocytoscopy, and autofluorescence imaging. The Kudo classification of pit patterns was most frequently used, with pooled SE 83%, SP 83%, and NPV 95%. The endoscopic criteria with the highest accuracy, with minimum SE ⩾ 90%, SP ⩾ 80%, and NPV ⩾ 90% were: the Kudo-IBD classification used with VCE (Fuji Intelligent Color Enhancement and i-SCAN); combined irregular surface and vascular patterns used with narrow band imaging; the Mainz classification used with CLE. Multiple clinical and technical factors were found to influence the accuracy of optical diagnosis in IBD.

Conclusion

No single endoscopic factor has yet shown sufficient accuracy for lesion characterization in IBD surveillance. Conventional classifications developed in the non-IBD setting have lower accuracy in IBD. The use of new classifications adapted for IBD (Kudo-IBD), and new technologies based on in vivo microscopic analysis show promise.

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Hirose T, Kato M, Hatta W, Abe S, Takizawa K, Yano T. Superficial non-ampullary duodenal epithelial tumors now: endoscopic diagnosis and therapy. Jpn J Clin Oncol 2023;53:877-884. [PMID: 37394910 DOI: 10.1093/jjco/hyad073] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/26/2023] [Accepted: 06/15/2023] [Indexed: 07/04/2023] Open

Kubo M, Ono S, Yokota I, Matsumoto S, Nishimura Y, Ono M, Yamamoto K, Sakamoto N. Quantitative diagnostic algorithm using endocytoscopy for superficial nonampullary duodenal epithelial tumors. J Gastroenterol Hepatol 2023;38:1496-1502. [PMID: 37129220 DOI: 10.1111/jgh.16207] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/11/2023] [Revised: 03/03/2023] [Accepted: 04/20/2023] [Indexed: 05/03/2023]

Biamonte P, D’Amico F, Fasulo E, Barà R, Bernardi F, Allocca M, Zilli A, Danese S, Furfaro F. New Technologies in Digestive Endoscopy for Ulcerative Colitis Patients. Biomedicines 2023;11:2139. [PMID: 37626636 PMCID: PMC10452412 DOI: 10.3390/biomedicines11082139] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/13/2023] [Revised: 07/25/2023] [Accepted: 07/27/2023] [Indexed: 08/27/2023] Open

Hong SM, Baek DH. A Review of Colonoscopy in Intestinal Diseases. Diagnostics (Basel) 2023;13:diagnostics13071262. [PMID: 37046479 PMCID: PMC10093393 DOI: 10.3390/diagnostics13071262] [Citation(s) in RCA: 8] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/01/2023] [Revised: 03/25/2023] [Accepted: 03/26/2023] [Indexed: 03/30/2023] Open

Liu Y, Wen H, Wang Q, Du S. Research trends in endoscopic applications in early gastric cancer: A bibliometric analysis of studies published from 2012 to 2022. Front Oncol 2023;13:1124498. [PMID: 37114137 PMCID: PMC10129370 DOI: 10.3389/fonc.2023.1124498] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/15/2022] [Accepted: 03/13/2023] [Indexed: 04/29/2023] Open

Abstract

Background

Endoscopy is the optimal method of diagnosing and treating early gastric cancer (EGC), and it is therefore important to keep up with the rapid development of endoscopic applications in EGC. This study utilized bibliometric analysis to describe the development, current research progress, hotspots, and emerging trends in this field.

Methods

We retrieved publications about endoscopic applications in EGC from 2012 to 2022 from Web of Science™ (Clarivate™, Philadelphia, PA, USA) Core Collection (WoSCC). We mainly used CiteSpace (version 6.1.R3) and VOSviewer (version 1.6.18) to perform the collaboration network analysis, co-cited analysis, co-occurrence analysis, cluster analysis, and burst detection.

Results

A total of 1,333 publications were included. Overall, both the number of publications and the average number of citations per document per year increased annually. Among the 52 countries/regions that were included, Japan contributed the most in terms of publications, citations, and H-index, followed by the Republic of Korea and China. The National Cancer Center, based in both Japan and the Republic of Korea, ranked first among institutions in terms of number of publications, citation impact, and the average number of citations. Yong Chan Lee was the most productive author, and Ichiro Oda had the highest citation impact. In terms of cited authors, Gotoda Takuji had both the highest citation impact and the highest centrality. Among journals, Surgical Endoscopy and Other Interventional Techniques had the most publications, and Gastric Cancer had the highest citation impact and H-index. Among all publications and cited references, a paper by Smyth E C et al., followed by one by Gotoda T et al., had the highest citation impact. Using keywords co-occurrence and cluster analysis, 1,652 author keywords were categorized into 26 clusters, and we then divided the clusters into six groups. The largest and newest clusters were endoscopic submucosal dissection and artificial intelligence (AI), respectively.

Conclusions

Over the last decade, research into endoscopic applications in EGC has gradually increased. Japan and the Republic of Korea have contributed the most, but research in this field in China, from an initially low base, is developing at a striking speed. However, a lack of collaboration among countries, institutions, and authors, is common, and this should be addressed in future. The main focus of research in this field (i.e., the largest cluster) is endoscopic submucosal dissection, and the topic at the frontier (i.e., the newest cluster) is AI. Future research should focus on the application of AI in endoscopy, and its implications for the clinical diagnosis and treatment of EGC.

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Haji A. Endoscopic Submucosal Dissection in the Colon and Rectum: Indications, Techniques, and Outcomes. Gastrointest Endosc Clin N Am 2023;33:83-97. [PMID: 36375889 DOI: 10.1016/j.giec.2022.08.001] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/12/2022]

Katrevula A, Katukuri GR, Singh AP, Inavolu P, Rughwani H, Alla SR, Ramchandani M, Duvvur NR. Real-World Experience of AI-Assisted Endocytoscopy Using EndoBRAIN—An Observational Study from a Tertiary Care Center. JOURNAL OF DIGESTIVE ENDOSCOPY 2022. [DOI: 10.1055/s-0042-1758535] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/25/2022] Open

Abstract Abstract Background and Aims Precise optical diagnosis of colorectal polyps could improve the cost-effectiveness of colonoscopy and reduce polypectomy-related complications. We conducted this study to estimate the diagnostic performance of visual inspection alone (WLI + NBI) and of EndoBRAIN (endocytoscopy-computer-aided diagnosis [EC-CAD]) in identifying a lesion as neoplastic or nonneoplastic using EC in real-world scenario. Methods In this observational, prospective, pilot study, a total of 55 polyps were studied in the patients aged more than or equal to 18 years. EndoBRAIN is an artificial intelligence (AI)-based system that analyzes cell nuclei, crypt structure, and vessel pattern in differentiating neoplastic and nonneoplastic lesion in real-time. Endoscopist assessed polyps using white light imaging (WLI), narrow band imaging (NBI) initially followed by assessment using EC with NBI and EC with methylene blue staining. The sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of endoscopist and EndoBRAIN in identifying the neoplastic from nonneoplastic polyp was compared using histopathology as gold-standard. Results A total of 55 polyps were studied, in which most of them were diminutive (36/55) and located in rectum (21/55). The image acquisition rate was 78% (43/55) and histopathology of the majority was identified to be hyperplastic (20/43) and low-grade adenoma (16/43). EndoBRAIN identified colonic polyps with 100% sensitivity, 81.82% specificity (95% confidence interval [CI], 59.7–94.8%), 90.7% accuracy (95% CI, 77.86–97.41%), 84% positive predictive value (95% CI, 68.4–92.72%), and 100% negative predictive value. The sensitivity and negative predictive value were significantly greater than visual inspection of endoscopist. The diagnostic accuracy seems to be superior; however, it did not reach statistical significance. Specificity and positive predictive value were similar in both groups. Conclusion Optical diagnosis using EC and EC-CAD has a potential role in predicting the histopathological diagnosis. The diagnostic performance of CAD seems to be better than endoscopist using EC for predicting neoplastic lesions. Collapse

Maeda Y, Kudo SE, Ogata N, Kuroki T, Takashina Y, Takishima K, Ogawa Y, Ichimasa K, Mori Y, Kudo T, Hayashi T, Miyachi H, Ishida F, Nemoto T, Ohtsuka K, Misawa M. Use of advanced endoscopic technology for optical characterization of neoplasia in patients with ulcerative colitis: Systematic review. Dig Endosc 2022;34:1297-1310. [PMID: 35445457 DOI: 10.1111/den.14335] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/12/2022] [Accepted: 04/18/2022] [Indexed: 02/08/2023]

Abstract

OBJECTIVES

Advances in endoscopic technology, including magnifying and image-enhanced techniques, have been attracting increasing attention for the optical characterization of colorectal lesions. These techniques are being implemented into clinical practice as cost-effective and real-time approaches. Additionally, with the recent progress in endoscopic interventions, endoscopic resection is gaining acceptance as a treatment option in patients with ulcerative colitis (UC). Therefore, accurate preoperative characterization of lesions is now required. However, lesion characterization in patients with UC may be difficult because UC is often affected by inflammation, and it may be characterized by a distinct "bottom-up" growth pattern, and even expert endoscopists have relatively little experience with such cases. In this systematic review, we assessed the current status and limitations of the use of optical characterization of lesions in patients with UC.

METHODS

A literature search of online databases (MEDLINE via PubMed and CENTRAL via the Cochrane Library) was performed from 1 January 2000 to 30 November 2021.

RESULTS

The database search initially identified 748 unique articles. Finally, 25 studies were included in the systematic review: 23 focused on differentiation of neoplasia from non-neoplasia, one focused on differentiation of UC-associated neoplasia from sporadic neoplasia, and one focused on differentiation of low-grade dysplasia from high-grade dysplasia and cancer.

CONCLUSIONS

Optical characterization of neoplasia in patients with UC, even using advanced endoscopic technology, is still challenging and several issues remain to be addressed. We believe that the information revealed in this review will encourage researchers to commit to the improvement of optical diagnostics for UC-associated lesions.

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Toyoshima N, Saito Y, Yamada M, Takamaru H, Sekine S, Kasuga K, Kudo SE. Early colorectal lesion (depressed type) detected using artificial intelligence. Endoscopy 2022;54:E648-E649. [PMID: 35120394 DOI: 10.1055/a-1732-7197] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 01/02/2023]

Utsunomiya M, Tsuji S, Kawasaki A, Takemura K, Katayanagi K, Minato H, Doyama H. Real-time histological imaging of a squamous cell carcinoma in situ in the anal canal using endocytoscopy. Endoscopy 2022;54:E518-E519. [PMID: 34695849 DOI: 10.1055/a-1655-8401] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 12/10/2022]

Hiramatsu Y, Utsumi T, Higuchi H, Hayashi J, Horimatsu T, Nikaido M, Nakanishi Y, Shimizu T, Muto M, Seno H. Thermal tissue damage caused by new endoscope model due to light absorption. J Gastroenterol Hepatol 2022;37:1801-1805. [PMID: 35861136 DOI: 10.1111/jgh.15963] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/25/2022] [Revised: 07/05/2022] [Accepted: 07/11/2022] [Indexed: 12/09/2022]

Colorectal Cancer in Ulcerative Colitis: Mechanisms, Surveillance and Chemoprevention. Curr Oncol 2022;29:6091-6114. [PMID: 36135048 PMCID: PMC9498229 DOI: 10.3390/curroncol29090479] [Citation(s) in RCA: 44] [Impact Index Per Article: 14.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/11/2022] [Revised: 08/14/2022] [Accepted: 08/18/2022] [Indexed: 11/17/2022] Open

Takishima K, Maeda Y, Ogata N, Misawa M, Mori Y, Homma M, Nemoto T, Miyata Y, Akimoto Y, Mochida K, Takashina Y, Tanaka K, Ichimasa K, Nakamura H, Sasanuma S, Kudo T, Hayashi T, Wakamura K, Miyachi H, Baba T, Ishida F, Ohtsuka K, Kudo SE. Beyond complete endoscopic healing: Goblet appearance using an endocytoscope to predict future sustained clinical remission in ulcerative colitis. Dig Endosc 2022;34:1030-1039. [PMID: 34816494 DOI: 10.1111/den.14202] [Citation(s) in RCA: 14] [Impact Index Per Article: 4.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/06/2021] [Revised: 11/09/2021] [Accepted: 11/21/2021] [Indexed: 12/13/2022]

Affiliation(s)

Kazumi Takishima Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Yasuharu Maeda Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Noriyuki Ogata Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Masashi Misawa Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Yuichi Mori Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan Clinical Effectiveness Research Group, University of Oslo, Oslo, Norway
Mayumi Homma Department of Diagnostic Pathology, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Tetsuo Nemoto Department of Diagnostic Pathology, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Yuki Miyata Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Yoshika Akimoto Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Kentaro Mochida Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Yuki Takashina Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Kenta Tanaka Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Katsuro Ichimasa Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Hiroki Nakamura Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Seiko Sasanuma Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Toyoki Kudo Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Takemasa Hayashi Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Kunihiko Wakamura Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Hideyuki Miyachi Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Toshiyuki Baba Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Fumio Ishida Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Kazuo Ohtsuka Department of Endoscopy, Tokyo Medical and Dental University, Medical Hospital, Tokyo, Japan
Shin-Ei Kudo Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan

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Toyoshima O, Nishizawa T, Yoshida S, Watanabe H, Odawara N, Sakitani K, Arano T, Takiyama H, Kobayashi H, Kogure H, Fujishiro M. Brown slits for colorectal adenoma crypts on conventional magnifying endoscopy with narrow band imaging using the X1 system. World J Gastroenterol 2022;28:2748-2757. [PMID: 35979159 PMCID: PMC9260865 DOI: 10.3748/wjg.v28.i24.2748] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/16/2022] [Revised: 03/14/2022] [Accepted: 05/14/2022] [Indexed: 02/06/2023] Open

Abstract

BACKGROUND

Accurate diagnosis of colorectal premalignant polyps, including adenomas, is vital in clinical practice.

AIM

To investigate the diagnostic yields of novel findings of brown slits for adenomas.

METHODS

Patients who underwent colonoscopy at the Toyoshima Endoscopy Clinic were enrolled. Polyps sized ≥ 5 mm suspected of adenomas or clinically significant serrated polyps were included in the study. We defined the surface structures of colorectal polyps, which were brown curves inside and along the tubular glands identified using a combination of a new X1 system (Olympus Corporation) and a conventional magnifying colonoscope with non-staining narrow band imaging (NBI), as brown slits. The brown slits corresponded to slit-like lumens on endocytoscopy and histological crypt openings of an adenoma. We evaluated the diagnostic performance of brown slits for adenoma.

RESULTS

A total of 108 Lesions from 62 patients were eligible. The average age was 60.4 years and 41.9% were male. The mean polyp size was 7.45 ± 2.83 mm. Fifty-seven lesions were positive for brown slits. Histopathological diagnosis comprised 59 low-grade tubular adenomas, 16 sessile serrated lesions, and 33 hyperplastic polyps. Among 59 adenomas, 56 (94.9%) were positive for brown slits. Among 16 sessile serrated lesions, 0 (0%) was positive for brown slits. Among 33 hyperplastic polyps, 1 (3.0%) was positive for brown slits. The sensitivity, specificity, and accuracy of brown slits for adenoma were 94.9%, 98.0%, and 96.3%, respectively. The positive predictive value and negative predictive value of brown slits for adenoma were also excellent for 98.2%, and 94.1%, respectively.

CONCLUSION

Brown slits on conventional magnifying endoscopy with non-staining NBI using the X1 system were useful for diagnosing colorectal adenoma. The new endoscopy system could be examined using new standards.

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Kudo SE, Misawa M. Progress in magnifying colonoscopy: Road to optical biopsy. Dig Endosc 2022;34 Suppl 2:91-94. [PMID: 34697836 DOI: 10.1111/den.14141] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 01/18/2023]

Akiyama S, Sakamoto T, Steinberg JM, Saito Y, Tsuchiya K. Evolving roles of magnifying endoscopy and endoscopic resection for neoplasia in inflammatory bowel diseases. World J Gastrointest Oncol 2022;14:646-653. [PMID: 35321277 PMCID: PMC8919023 DOI: 10.4251/wjgo.v14.i3.646] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/01/2021] [Revised: 12/06/2021] [Accepted: 02/12/2022] [Indexed: 02/06/2023] Open

Kudo SE, Maeda Y, Ogata N, Misawa M, Ogawa Y, Takishima K, Ishiyama M, Mochizuki K, Minegishi Y, Ogura Y, Abe M, Okumura T, Matsudaira S, Ishigaki T, Sasanuma S, Mori Y, Kudo T, Hayashi T, Wakamura K, Miyachi H, Baba T, Ishida F, Nemoto T, Hamatani S, Ohtsuka K. Combined endocytoscopy with pit pattern diagnosis in ulcerative colitis-associated neoplasia: Pilot study. Dig Endosc 2022;34:133-143. [PMID: 33641190 DOI: 10.1111/den.13964] [Citation(s) in RCA: 12] [Impact Index Per Article: 4.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/15/2020] [Revised: 02/08/2021] [Accepted: 02/24/2021] [Indexed: 12/15/2022]

Affiliation(s)

Shin-Ei Kudo Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Yasuharu Maeda Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Noriyuki Ogata Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Masashi Misawa Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Yushi Ogawa Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Kazumi Takishima Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Misaki Ishiyama Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Kenichi Mochizuki Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Yosuke Minegishi Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Yohei Ogura Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Masahiro Abe Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Taishi Okumura Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Shingo Matsudaira Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Tomoyuki Ishigaki Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Seiko Sasanuma Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Yuichi Mori Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Toyoki Kudo Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Takemasa Hayashi Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Kunihiko Wakamura Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Hideyuki Miyachi Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Toshiyuki Baba Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Fumio Ishida Digestive Disease Center, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Tetsuo Nemoto Department of Diagnostic Pathology, Showa University Northern Yokohama Hospital, Kanagawa, Japan
Shigeharu Hamatani Department of Pathology, Jikei University School of Medicine, Tokyo, Japan
Kazuo Ohtsuka Endoscopy Department, Tokyo Medical and Dental University, Tokyo, Japan

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Ikematsu H, Murano T, Shinmura K. Depth diagnosis of early colorectal cancer: Magnifying chromoendoscopy or image enhanced endoscopy with magnification? Dig Endosc 2022;34:265-273. [PMID: 34289171 DOI: 10.1111/den.14087] [Citation(s) in RCA: 6] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/30/2021] [Revised: 07/05/2021] [Accepted: 07/19/2021] [Indexed: 12/28/2022]

Shiratsuki Y, Kurimoto N, Amano Y, Hamaguchi S, Kobayashi M, Okuno T, Hotta T, Tsubata Y, Isobe T. Ultra-magnifying Imaging of Thoracoscopic Biopsy Specimens Using Ex vivo Endocytoscopy in Three Patients with Mesothelioma. Intern Med 2022;61:3251-3257. [PMID: 36328587 PMCID: PMC9683823 DOI: 10.2169/internalmedicine.9173-21] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/05/2022] Open

Fujiyoshi MRA, Inoue H, Fujiyoshi Y, Nishikawa Y, Toshimori A, Shimamura Y, Tanabe M, Ikeda H, Onimaru M. Endoscopic Classifications of Early Gastric Cancer: A Literature Review. Cancers (Basel) 2021;14:100. [PMID: 35008263 PMCID: PMC8750452 DOI: 10.3390/cancers14010100] [Citation(s) in RCA: 13] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/31/2021] [Revised: 12/04/2021] [Accepted: 12/22/2021] [Indexed: 12/14/2022] Open

Hirose T, Kakushima N, Furukawa K, Furune S, Ishikawa E, Sawada T, Maeda K, Yamamura T, Ishikawa T, Ohno E, Nakamura M, Nishida K, Yokoi T, Kawashima H, Fujishiro M. Endocytoscopy Is Useful for the Diagnosis of Superficial Nonampullary Duodenal Epithelial Tumors. Digestion 2021;102:895-902. [PMID: 34098561 DOI: 10.1159/000516512] [Citation(s) in RCA: 9] [Impact Index Per Article: 2.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/30/2020] [Accepted: 03/27/2021] [Indexed: 02/04/2023]

Muramoto T, Ohata K, Sakai E, Inamoto R, Kurebayashi M, Takayanagi S, Kimoto Y, Suzuki Y, Ishii R, Ono K, Negishi R, Takita M, Minato Y, Ohno A, Chiba H, Hashimoto H, Morikawa T, Matsuhashi N. A new classification for the diagnosis of superficial non-ampullary duodenal epithelial tumors using endocytoscopy: A prospective study. J Gastroenterol Hepatol 2021;36:3170-3176. [PMID: 34142381 DOI: 10.1111/jgh.15585] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/28/2021] [Revised: 06/08/2021] [Accepted: 06/13/2021] [Indexed: 12/09/2022]

Misawa M, Kudo SE, Takashina Y, Akimoto Y, Maeda Y, Mori Y, Kudo T, Wakamura K, Miyachi H, Ishida F, Inoue H. Clinical Efficacy of Endocytoscopy for Gastrointestinal Endoscopy. Clin Endosc 2021;54:455-463. [PMID: 34233111 PMCID: PMC8357585 DOI: 10.5946/ce.2021.165] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/21/2021] [Accepted: 06/10/2021] [Indexed: 12/15/2022] Open

Kawasaki K, Nakamura S, Eizuka M, Tanaka Y, Kumei T, Yanai S, Toya Y, Urushikubo J, Torisu T, Moriyama T, Umeno J, Sugai T, Matsumoto T. Is barium enema examination negligible for the management of colorectal cancer? Comparison with conventional colonoscopy and magnifying colonoscopy. Jpn J Radiol 2021;39:1159-1167. [PMID: 34164768 DOI: 10.1007/s11604-021-01157-x] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/22/2021] [Accepted: 06/12/2021] [Indexed: 12/15/2022]

Iwagami H, Uedo N, Yip HC, Shichijo S, Kanesaka T, Maekawa A, Yamamoto S, Higashino K, Takeuchi Y, Ishihara R, Nakatsuka SI. Ultra-magnifying narrow-band imaging for endoscopic diagnosis of gastric intestinal metaplasia: a pilot image analysis study. Endosc Int Open 2021;9:E522-E529. [PMID: 33816772 PMCID: PMC7969138 DOI: 10.1055/a-1352-2500] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/10/2020] [Accepted: 11/24/2020] [Indexed: 12/15/2022] Open

Okamoto Y, Oka S, Tanaka S, Kamigaichi Y, Tamari H, Shimohara Y, Nishimura T, Inagaki K, Tanaka H, Matsumoto K, Yamashita K, Sumimoto K, Ninomiya Y, Hayashi N, Kitadai Y, Yoshimura K, Chayama K. Effect of educational lecture on the diagnostic accuracy of Japan NBI Expert Team classification for colorectal lesions. BMC Gastroenterol 2021;21:110. [PMID: 33663383 PMCID: PMC7934459 DOI: 10.1186/s12876-021-01676-x] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/02/2021] [Accepted: 02/16/2021] [Indexed: 02/07/2023] Open

Abstract

BACKGROUND

An educational and training program is required for generalization of Japan NBI Expert Team (JNET) classification. However, there is no detailed report on the learning curve of the diagnostic accuracy of endoscopists using JNET classification. We examined the effect of an educational lecture on beginners and less experienced endoscopists for improving their diagnostic accuracy of colorectal lesions by JNET classification.

METHODS

Seven beginners with no endoscopy experience (NEE group), 7 less experienced endoscopists (LEE group), and 3 highly experienced endoscopists (HEE group) performed diagnosis using JNET classification for randomized NBI images of colorectal lesions from 180 cases (Type 1: 22 cases, Type 2A: 105 cases, Type 2B: 33 cases, and Type 3: 20 cases). Next, the NEE and LEE groups received a lecture on JNET classification, and all 3 groups repeated the diagnostic process. We compared the correct diagnosis rate and interobserver agreement before and after the lecture comprehensively and for each JNET type.

RESULTS

In the HEE group, the correct diagnosis rate was more than 90% with good interobserver agreements (kappa value: 0.78-0.85). In the NEE and LEE groups, the correct diagnosis rate (NEE: 60.2 → 68.0%, P < 0.01; LEE: 66.4 → 86.7%, P < 0.01), high-confidence correct diagnosis rate (NEE: 19.6 → 37.2%, P < 0.01; LEE: 43.6 → 61.1%, P < 0.01), and interobserver agreement (kappa value, NEE: 0.32 → 0.43; LEE: 0.39 → 0.75) improved after the lecture. In the examination by each JNET type, the specificity and positive predictive value in the NEE and LEE groups generally improved after the lecture.

CONCLUSION

After conducting an appropriate lecture, the diagnostic ability using JNET classification was improved in beginners or endoscopists with less experience in NBI magnifying endoscopy.

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Affiliation(s)

Yuki Okamoto Department of Gastroenterology and Metabolism, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
Shiro Oka Department of Gastroenterology and Metabolism, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan.
Shinji Tanaka Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
Yuki Kamigaichi Department of Gastroenterology and Metabolism, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
Hirosato Tamari Department of Gastroenterology and Metabolism, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
Yasutsugu Shimohara Department of Gastroenterology and Metabolism, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
Tomoyuki Nishimura Department of Gastroenterology and Metabolism, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
Katsuaki Inagaki Department of Gastroenterology and Metabolism, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
Hidenori Tanaka Department of Gastroenterology and Metabolism, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
Kenta Matsumoto Department of Gastroenterology and Metabolism, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan
Ken Yamashita Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
Kyoku Sumimoto Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
Yuki Ninomiya Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
Nana Hayashi Department of Endoscopy, Hiroshima University Hospital, Hiroshima, Japan
Yasuhiko Kitadai Department of Health Sciences, Prefectural University of Hiroshima, Hiroshima, Japan
Kenichi Yoshimura Center for Integrated Medical Research, Hiroshima University Hospital, Hiroshima, Japan
Kazuaki Chayama Department of Gastroenterology and Metabolism, Hiroshima University Hospital, 1-2-3, Kasumi, Minami-ku, Hiroshima, 734-8551, Japan

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Computer-aided diagnosis system using only white-light endoscopy for the prediction of invasion depth in colorectal cancer. Gastrointest Endosc 2021;93:647-653. [PMID: 32735946 DOI: 10.1016/j.gie.2020.07.053] [Citation(s) in RCA: 14] [Impact Index Per Article: 3.5] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/23/2020] [Accepted: 07/24/2020] [Indexed: 02/06/2023]

Inoue F, Sano Y, Hirata D, Iwatate M, Fujimori T. A case of anal condyloma acuminatum observed by endocytoscopy. VideoGIE 2021;6:141-143. [PMID: 33738367 PMCID: PMC7947249 DOI: 10.1016/j.vgie.2020.11.007] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 11/17/2022] Open

AL-Kandari A, Neumann H. Endocytoscopy for Luminal Gastrointestinal Diseases: A Systematic Review. TECHNIQUES AND INNOVATIONS IN GASTROINTESTINAL ENDOSCOPY 2021;23:77-86. [DOI: 10.1016/j.tige.2020.09.004] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 01/04/2025]

Peshevska-Sekulovska M, Velikova TV, Peruhova M. Artificial intelligence assisted endocytoscopy: A novel eye in endoscopy. Artif Intell Gastrointest Endosc 2020;1:44-52. [DOI: 10.37126/aige.v1.i3.44] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/01/2020] [Revised: 11/29/2020] [Accepted: 12/06/2020] [Indexed: 02/06/2023] Open

Barua I, Mori Y, Bretthauer M. Colorectal polyp characterization with endocytoscopy: Ready for widespread implementation with artificial intelligence? Best Pract Res Clin Gastroenterol 2020;52-53:101721. [PMID: 34172248 DOI: 10.1016/j.bpg.2020.101721] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/15/2020] [Revised: 12/07/2020] [Accepted: 12/15/2020] [Indexed: 01/31/2023]

Ono S, Nozaki A, Matsuda K, Takakuwa E, Sakamoto N, Watari H. In vivo optical cellular diagnosis for uterine cervical or vaginal intraepithelial neoplasia using flexible gastrointestinal endocytoscopy -a prospective pilot study. BMC Cancer 2020;20:955. [PMID: 33008349 PMCID: PMC7530973 DOI: 10.1186/s12885-020-07460-6] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/11/2020] [Accepted: 09/24/2020] [Indexed: 12/24/2022] Open

Abstract

Backgrouund

For patients with any kind of atypical squamous intraepithelial lesion of the uterine cervix or vagina, colposcopy and punch biopsy are common procedures for histological determination following cytology. However, colposcopy-guided biopsy does not provide a high level of diagnostic accuracy. The aim of this study was to determine the usefulness of optical biopsy in vivo using endocytoscopy compared with conventional procedures using colposcopy.

Methods

Between May 2018 and March 2019, patients who were scheduled for cervical conization or mapping biopsies of the vagina were prospectively enrolled. Endocytoscopy was performed by senior endoscopists prior to scheduled procedures, and endocytoscopic images and biopsy samples were taken from the most prominent site and surrounding area of the cervical or vaginal lesions. The collection process of images was randomized and anonymous, and three doctors separately evaluated the images according to the ECA classification. ECA 4 and 5 are indicative of endoscopic malignancy. The primary endpoint was diagnostic accuracy (benign or malignant: cervical intraepithelial neoplasia (CIN) 3 or vaginal intraepithelial neoplasia (VAIN) 3 or worse) of cell images at the most prominent site in each patient.

Results

A total of 28 consecutive patients were enrolled. Sensitivity, specificity, positive predictive value, negative predictive value and accuracy of endocytoscopic images were 95.0% (84.8–98.6%), 87.5% (61.9–96.5%), 95.0% (84.8–98.6%), 87.5% (61.9–96.5%) and 92.9% (78.2–98.0%), respectively. Inter-observer agreement among three reviewers was 0.78 (0.08–9.88, P < 0.01). On the other hand, the accuracy of colposcopy-guided biopsy was 74.1% (64.0–84.0%).

Conclusions

Optical cell diagnosis of cervical or vaginal intraepithelial neoplasia using endocytoscopy provides a high level of diagnostic accuracy.

Trial registration

The study was registered with the UMIN database (ID: 000031712).

UMIN000031712. Registered 16 March 2017,

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Akimoto Y, Kudo SE, Ichimasa K, Kouyama Y, Misawa M, Hisayuki T, Kudo T, Nemoto T. Small invasive colon cancer with adenoma observed by endocytoscopy: A case report. World J Gastrointest Endosc 2020;12:304-309. [PMID: 32994861 PMCID: PMC7503619 DOI: 10.4253/wjge.v12.i9.304] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/27/2020] [Revised: 07/16/2020] [Accepted: 08/24/2020] [Indexed: 02/06/2023] Open

Takamaru H, Wu SYS, Saito Y. Endocytoscopy: technology and clinical application in the lower GI tract. Transl Gastroenterol Hepatol 2020;5:40. [PMID: 32632391 DOI: 10.21037/tgh.2019.12.04] [Citation(s) in RCA: 11] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/08/2019] [Accepted: 11/13/2019] [Indexed: 12/13/2022] Open

Kudo SE, Misawa M, Mori Y, Hotta K, Ohtsuka K, Ikematsu H, Saito Y, Takeda K, Nakamura H, Ichimasa K, Ishigaki T, Toyoshima N, Kudo T, Hayashi T, Wakamura K, Baba T, Ishida F, Inoue H, Itoh H, Oda M, Mori K. Artificial Intelligence-assisted System Improves Endoscopic Identification of Colorectal Neoplasms. Clin Gastroenterol Hepatol 2020;18:1874-1881.e2. [PMID: 31525512 DOI: 10.1016/j.cgh.2019.09.009] [Citation(s) in RCA: 141] [Impact Index Per Article: 28.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/02/2019] [Revised: 08/30/2019] [Accepted: 09/08/2019] [Indexed: 02/06/2023]

Abstract

BACKGROUND & AIMS

Precise optical diagnosis of colorectal polyps could improve the cost-effectiveness of colonoscopy and reduce polypectomy-related complications. However, it is difficult for community-based non-experts to obtain sufficient diagnostic performance. Artificial intelligence-based systems have been developed to analyze endoscopic images; they identify neoplasms with high accuracy and low interobserver variation. We performed a multi-center study to determine the diagnostic accuracy of EndoBRAIN, an artificial intelligence-based system that analyzes cell nuclei, crypt structure, and microvessels in endoscopic images, in identification of colon neoplasms.

METHODS

The EndoBRAIN system was initially trained using 69,142 endocytoscopic images, taken at 520-fold magnification, from patients with colorectal polyps who underwent endoscopy at 5 academic centers in Japan from October 2017 through March 2018. We performed a retrospective comparative analysis of the diagnostic performance of EndoBRAIN vs that of 30 endoscopists (20 trainees and 10 experts); the endoscopists assessed images from 100 cases produced via white-light microscopy, endocytoscopy with methylene blue staining, and endocytoscopy with narrow-band imaging. EndoBRAIN was used to assess endocytoscopic, but not white-light, images. The primary outcome was the accuracy of EndoBrain in distinguishing neoplasms from non-neoplasms, compared with that of endoscopists, using findings from pathology analysis as the reference standard.

RESULTS

In analysis of stained endocytoscopic images, EndoBRAIN identified colon lesions with 96.9% sensitivity (95% CI, 95.8%-97.8%), 100% specificity (95% CI, 99.6%-100%), 98% accuracy (95% CI, 97.3%-98.6%), a 100% positive-predictive value (95% CI, 99.8%-100%), and a 94.6% negative-predictive (95% CI, 92.7%-96.1%); these values were all significantly greater than those of the endoscopy trainees and experts. In analysis of narrow-band images, EndoBRAIN distinguished neoplastic from non-neoplastic lesions with 96.9% sensitivity (95% CI, 95.8-97.8), 94.3% specificity (95% CI, 92.3-95.9), 96.0% accuracy (95% CI, 95.1-96.8), a 96.9% positive-predictive value, (95% CI, 95.8-97.8), and a 94.3% negative-predictive value (95% CI, 92.3-95.9); these values were all significantly higher than those of the endoscopy trainees, sensitivity and negative-predictive value were significantly higher but the other values are comparable to those of the experts.

CONCLUSIONS

EndoBRAIN accurately differentiated neoplastic from non-neoplastic lesions in stained endocytoscopic images and endocytoscopic narrow-band images, when pathology findings were used as the standard. This technology has been authorized for clinical use by the Japanese regulatory agency and should be used in endoscopic evaluation of small polyps more widespread clinical settings. UMIN clinical trial no: UMIN000028843.

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Affiliation(s)

Shin-Ei Kudo Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan.
Masashi Misawa Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
Yuichi Mori Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
Kinichi Hotta Division of Endoscopy, Shizuoka Cancer Center Hospital, Shizuoka, Japan
Kazuo Ohtsuka Department of Endoscopy, Tokyo Medical and Dental University, Tokyo, Japan
Hiroaki Ikematsu Department of Gastroenterology and Endoscopy, National Cancer Center Hospital East, Chiba, Japan
Yutaka Saito Endoscopy Division, National Cancer Center Hospital, Tokyo, Japan
Kenichi Takeda Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
Hiroki Nakamura Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
Katsuro Ichimasa Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
Tomoyuki Ishigaki Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
Naoya Toyoshima Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
Toyoki Kudo Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
Takemasa Hayashi Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
Kunihiko Wakamura Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
Toshiyuki Baba Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
Fumio Ishida Digestive Disease Center, Showa University Northern Yokohama Hospital, Yokohama, Japan
Haruhiro Inoue Digestive Disease Center, Showa University Koto Toyosu Hospital, Tokyo, Japan
Hayato Itoh Graduate School of Informatics, Nagoya University, Nagoya, Japan
Masahiro Oda Graduate School of Informatics, Nagoya University, Nagoya, Japan
Kensaku Mori Graduate School of Informatics, Nagoya University, Nagoya, Japan

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Abad MRA, Shimamura Y, Fujiyoshi Y, Seewald S, Inoue H. Endocytoscopy: technology and clinical application in upper gastrointestinal tract. Transl Gastroenterol Hepatol 2020;5:28. [PMID: 32258532 PMCID: PMC7063519 DOI: 10.21037/tgh.2019.11.12] [Citation(s) in RCA: 15] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/21/2019] [Accepted: 11/12/2019] [Indexed: 12/16/2022] Open

Kudo T, Suzuki K, Mori Y, Misawa M, Ichimasa K, Takeda K, Nakamura H, Maeda Y, Ogawa Y, Hayashi T, Wakamura K, Ishida F, Inoue H, Kudo SE. Endocytoscopy for the differential diagnosis of colorectal low-grade adenoma: a novel possibility for the "resect and discard" strategy. Gastrointest Endosc 2020;91:676-683. [PMID: 31785276 DOI: 10.1016/j.gie.2019.11.029] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/11/2019] [Accepted: 11/16/2019] [Indexed: 02/07/2023]

Abstract

BACKGROUND AND AIMS

Endocytoscopy, a next-generation endoscopic system, facilitates observation at a maximum magnification of ×520. To our knowledge, no study has reported high-precision diagnosis of colorectal low-grade adenoma, endoscopically. We aimed to reveal which endocytoscopic findings may be used as indicators of low-grade adenoma and to assess whether a "resect and discard" strategy using endocytoscopy is feasible.

METHODS

Lesions diagnosable with endocytoscopy were examined retrospectively between May 2005 and July 2017. A normal pit-like structure in endocytoscopic images was considered a normal pit (NP) sign and used as an indicator of low-grade adenoma. The primary outcome was the diagnostic accuracy of the NP sign for low-grade adenoma. We evaluated agreement rates between endocytoscopic and pathologic diagnosis for surveillance colonoscopy interval recommendation (SCIR) and performed a validation study to verify the agreement rates.

RESULTS

For 748 lesions in 573 cases diagnosed as colorectal adenoma using endocytoscopy, the results were as follows: sensitivity of the NP sign for low-grade adenoma, 85.0%; specificity, 90.7%; positive predictive value, 96.6%; negative predictive value, 66.1%; accuracy, 86.4%; and positive likelihood ratio, 9.2 (P < .001). The agreement rate between endocytoscopic and pathologic diagnosis for SCIR was 94.4% (95% confidence interval [CI], 92.2%-96.1%; P < .001) under United States guidelines and 96.3% (95% CI, 94.5%-97.7%; P < .001) under European Union guidelines. All inter- and intraobserver agreement rates for expert and nonexpert endoscopists had κ values ≥0.8 except one nonexpert pair.

CONCLUSIONS

Endocytoscopy is an effective modality in determining the differential diagnosis of colorectal low-grade adenoma. (University Hospital Medical Information Network Clinical Trials database registration number: UMIN000018623.).

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Kataoka S, Kudo SE, Misawa M, Nakamura H, Takeda K, Toyoshima N, Mori Y, Ogata N, Kudo T, Hisayuki T, Hayashi T, Wakamura K, Baba T, Ishida F. Endocytoscopy with NBI has the potential to correctly diagnose diminutive colorectal polyps that are difficult to diagnose using conventional NBI. Endosc Int Open 2020;8:E360-E367. [PMID: 32118108 PMCID: PMC7035040 DOI: 10.1055/a-1068-9228] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/27/2019] [Accepted: 10/14/2019] [Indexed: 02/07/2023] Open

Abstract

Background and study aims Real-time diagnosis of colorectal polyps is needed to prevent unnecessary resection of benign polyps. The vessels in hyperplastic polyps sometimes mimic the characteristic meshed capillary network of neoplastic lesions on non-magnified narrow-band imaging (NBI). Endocytoscopy in conjunction with NBI (EC-NBI) enables more detailed vessel observation. The current study evaluated whether EC-NBI can accurately diagnose small colorectal lesions with visible vessels on non-magnified NBI. Patients and methods This retrospective study was conducted from January to December 2016. During colonoscopy, lesion images were obtained using NBI and EC-NBI. On EC-NBI, lesions were classified as having "clear," "unclear," or "invisible" blood vessel margins. All specimens were resected and pathologically examined, and the association between vessel margin findings and pathological diagnosis was assessed. The lesion surface to vessel depth was measured in clear, unclear, and invisible lesions. Results Among 114 adenomas, 108 were clear, while six were unclear. Among 36 hyperplastic polyps, eight were clear, while 28 were unclear. A micro-network (MN) pattern was seen in 106 of 114 adenomas, and four of 36 hyperplastic polyps. The sensitivity, specificity, correct diagnostic rate, and positive and negative predictive values of clear blood vessel margins or a MN pattern as an adenoma index were 98.2 %, 69.4 %, 91.3 %, 91.1 %, and 92.6 %, respectively. EC-NBI correctly diagnosed 69.4 % (25/36) of hyperplastic polyps. The lesion surface-blood vessel distance was greater in unclear versus clear lesions ( P < 0.001), and invisible versus unclear lesions ( P < 0.001). Conclusions EC-NBI may effectively differentiate hyperplastic polyps with visible vessels from adenomas. Blood vessel depth affects visibility.

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Rath T, Morgenstern N, Vitali F, Atreya R, Neurath MF. Advanced Endoscopic Imaging in Colonic Neoplasia. Visc Med 2020;36:48-59. [PMID: 32110657 PMCID: PMC7036553 DOI: 10.1159/000505411] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/15/2019] [Accepted: 12/11/2019] [Indexed: 12/15/2022] Open

Abstract

BACKGROUND

Endoscopic imaging is a rapidly evolving field with a constant influx of new concepts and technologies. Since the introduction of video endoscopy and subsequently high-definition imaging as the first revolutions in gastrointestinal endoscopy, several technologies of virtual chromoendoscopy have been developed and brought to the market in the past decade, which have shaped and revolutionized for a second time our approach to endoscopic imaging. In parallel to these developments, microscopic imaging technologies, such as endomicroscopy and endocytoscopy, allow us to examine single cells within the mucosa in real time, thereby enabling histological diagnoses during ongoing endoscopy.

SUMMARY

In this review, we provide an overview on the technical background of different technologies of advanced endoscopic imaging, and then review and discuss their role and applications for the diagnosis and management of colorectal neoplasms as well as limitations and challenges that exist despite all technological improvements.

KEY MESSAGES

Technologies of advanced endoscopic imaging have profound impact not only on our imaging capabilities, they are also about to fundamentally change our approach to managing lesions in the gastrointestinal tract: not every lesion found during colonoscopy has to be excised or sent for histopathologic evaluation. However, before this becomes widespread reality, major obstacles such as patient acceptance, adoption by less trained endoscopists, and also legal aspects need to carefully addressed. The development of computer-aided diagnosis and artificial intelligence algorithms hold the potential to overcome the obstacles associated with the concept of optical biopsy and will most likely fundamentally facilitate, shape, and change decision making in the management of colorectal lesions.

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Tanaka S, Kashida H, Saito Y, Yahagi N, Yamano H, Saito S, Hisabe T, Yao T, Watanabe M, Yoshida M, Saitoh Y, Tsuruta O, Sugihara KI, Igarashi M, Toyonaga T, Ajioka Y, Kusunoki M, Koike K, Fujimoto K, Tajiri H. Japan Gastroenterological Endoscopy Society guidelines for colorectal endoscopic submucosal dissection/endoscopic mucosal resection. Dig Endosc 2020;32:219-239. [PMID: 31566804 DOI: 10.1111/den.13545] [Citation(s) in RCA: 223] [Impact Index Per Article: 44.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/16/2019] [Revised: 09/13/2019] [Accepted: 09/26/2019] [Indexed: 12/13/2022]