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For: Eshmuminov D, Becker D, Bautista Borrego L, Hefti M, Schuler MJ, Hagedorn C, Muller X, Mueller M, Onder C, Graf R, Weber A, Dutkowski P, Rudolf von Rohr P, Clavien PA. An integrated perfusion machine preserves injured human livers for 1 week. Nat Biotechnol 2020;38:189-198. [PMID: 31932726 PMCID: PMC7008032 DOI: 10.1038/s41587-019-0374-x] [Citation(s) in RCA: 262] [Impact Index Per Article: 52.4] [Reference Citation Analysis] [What about the content of this article? (0)] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/23/2018] [Accepted: 11/18/2019] [Indexed: 12/26/2022]
Number Cited by Other Article(s)
1
Puchany AJ, Hilmi I. Post-reperfusion syndrome in liver transplant recipients: What is new in prevention and management? World J Crit Care Med 2025;14:101777. [PMID: 40491878 PMCID: PMC11891853 DOI: 10.5492/wjccm.v14.i2.101777] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/26/2024] [Revised: 11/22/2024] [Accepted: 12/19/2024] [Indexed: 02/27/2025]  Open
2
Vervoorn MT, van Tuijl S, Ballan EM, Kaffka Genaamd Dengler SE, de Jager SCA, Sluijter JPG, Doevendans PA, van der Kaaij NP. A novel cardioprotective perfusion protocol prevents functional decline during extended normothermic ex situ heart perfusion of marginal porcine hearts. J Heart Lung Transplant 2025;44:961-971. [PMID: 39490458 DOI: 10.1016/j.healun.2024.10.016] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/02/2024] [Revised: 09/20/2024] [Accepted: 10/21/2024] [Indexed: 11/05/2024]  Open
3
Hessheimer AJ, Hartog H, Marcon F, Schlegel A, Adam R, Alwayn I, Angelico R, Antoine C, Berlakovich G, Bruggenwirth I, Calatayud D, Cardini B, Cillo U, Clavien PA, Czigany Z, De Carlis R, de Jonge J, De Meijer VE, Dondossola D, Domínguez-Gil B, Dutkowski P, Eden J, Eshmuminov D, Fundora Y, Gastaca M, Ghinolfi D, Justo I, Lesurtel M, Leuvenink H, Line PD, Lladó L, López López V, Lurje G, Marín LM, Monbaliu D, Muller X, Nadalin S, Nasralla D, Oniscu G, Patrono D, Pirenne J, Selzner M, Toso C, Troisi R, Van Beekum C, Watson C, Weissenbacher A, Zieniewicz K, Schneeberger S, Polak WG, Porte RJ, Fondevila C. Deceased donor liver utilisation and assessment: Consensus guidelines from the European Liver and Intestine Transplant Association. J Hepatol 2025;82:1089-1109. [PMID: 40189968 DOI: 10.1016/j.jhep.2025.01.042] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/17/2024] [Revised: 01/11/2025] [Accepted: 01/23/2025] [Indexed: 05/03/2025]
4
den Dekker AMP, Franssen A, Steyerberg EW, Lam H, Doppenberg JB, Alwayn IPJ. Donor-Related Risk Factors for Normothermic Machine Perfusion in Liver Transplantation: A Meta-Analysis. Liver Int 2025;45:e70116. [PMID: 40298438 PMCID: PMC12039471 DOI: 10.1111/liv.70116] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/20/2024] [Revised: 03/26/2025] [Accepted: 04/20/2025] [Indexed: 04/30/2025]
5
Tamaki Y, Hatayama N, Fujii Y, Naito M. A compact machine perfusion device for whole blood perfusion in isolated rat liver. J Artif Organs 2025;28:244-251. [PMID: 39363050 DOI: 10.1007/s10047-024-01474-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/06/2024] [Accepted: 09/19/2024] [Indexed: 10/05/2024]
6
Zhao Y, Lyu X, Sun Z, Zhang X, Cen J, Yang T, Xu X, Xing W, Zhao S, Wang B, Luo G. Continuous Blood Gas Control Based on Active Disturbance Rejection Control During Ex Vivo Porcine Liver Perfusion. Artif Organs 2025;49:967-976. [PMID: 39868805 DOI: 10.1111/aor.14955] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/11/2024] [Revised: 12/20/2024] [Accepted: 01/10/2025] [Indexed: 01/28/2025]
7
Subbiahanadar Chelladurai K, Selvan Christyraj JD, Rajagopalan K, Vadivelu K, Chandrasekar M, Das P, Kalimuthu K, Balamurugan N, Subramanian V, Selvan Christyraj JRS. Ex vivo functional whole organ in biomedical research: a review. J Artif Organs 2025;28:131-145. [PMID: 39592544 DOI: 10.1007/s10047-024-01478-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/07/2024] [Accepted: 07/29/2024] [Indexed: 11/28/2024]
8
Ly M, Babekuhl D, Niu A, Yousif P, Wang C, Lau NS, Gorrell MD, McCaughan GW, Crawford M, Pulitano C. Development of a Protocol for Long-Term Ex Vivo Normothermic Machine Perfusion of Rodent Livers. Artif Organs 2025. [PMID: 40386942 DOI: 10.1111/aor.15024] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/24/2024] [Revised: 03/02/2025] [Accepted: 04/30/2025] [Indexed: 05/20/2025]
9
Ortuño-Costela MC, Pinzani M, Vallier L. Cell therapy for liver disorders: past, present and future. Nat Rev Gastroenterol Hepatol 2025;22:329-342. [PMID: 40102584 DOI: 10.1038/s41575-025-01050-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 02/11/2025] [Indexed: 03/20/2025]
10
Spence PJ, Nahrendorf W, Bach FA. Moving beyond discovery science to a mechanistic understanding of human malaria. Curr Opin Microbiol 2025;85:102610. [PMID: 40288157 DOI: 10.1016/j.mib.2025.102610] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/31/2024] [Revised: 04/02/2025] [Accepted: 04/07/2025] [Indexed: 04/29/2025]
11
Filz von Reiterdank I, Mojoudi M, Bento R, Taggart MS, Dinicu AT, Wojtkiewicz G, Coert JH, Mink van der Molen AB, Weissleder R, Parekkadan B, Uygun K. Ex vivo machine perfusion as a platform for lentiviral gene delivery in rat livers. Gene Ther 2025:10.1038/s41434-025-00536-7. [PMID: 40263629 DOI: 10.1038/s41434-025-00536-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/22/2024] [Revised: 03/28/2025] [Accepted: 04/08/2025] [Indexed: 04/24/2025]
12
Harkins L, Vilarinho S, Saltzman WM. Targeting Polymeric Nanoparticles to Specific Cell Populations in the Liver. Biochemistry 2025;64:1685-1697. [PMID: 40127248 DOI: 10.1021/acs.biochem.4c00712] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/26/2025]
13
Vengohechea J, Vaquero-Rey A, Fondevila C, Hessheimer AJ. The role of renal replacement therapy in improving normothermic machine perfusion of liver grafts. GASTROENTEROLOGIA Y HEPATOLOGIA 2025;48:502336. [PMID: 39761725 DOI: 10.1016/j.gastrohep.2025.502336] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/18/2024] [Revised: 12/11/2024] [Accepted: 12/20/2024] [Indexed: 01/24/2025]
14
Huwyler F, Pfister M, Binz J, Tibbitt MW, Clavien PA. Benefits of multi-day ex situ perfusion include dampened ischemia reperfusion injury in liver transplantation. J Hepatol 2025:S0168-8278(25)00208-9. [PMID: 40147789 DOI: 10.1016/j.jhep.2025.03.020] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 03/07/2025] [Revised: 03/20/2025] [Accepted: 03/20/2025] [Indexed: 03/29/2025]
15
Hagenbuch B, Stieger B, Locher KP. Organic anion transporting polypeptides: Pharmacology, toxicology, structure, and transport mechanisms. Pharmacol Rev 2025;77:100023. [PMID: 40148036 DOI: 10.1016/j.pharmr.2024.100023] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/07/2024] [Accepted: 11/12/2024] [Indexed: 03/29/2025]  Open
16
Pavan-Guimaraes J, Devos L, Lascaris B, de Meijer VE, Monbaliu D, Jochmans I, Pulitano C, Porte RJ, Martins PN. Long-Term Liver Machine Perfusion Preservation: A Review of Recent Advances, Benefits and Logistics. Artif Organs 2025;49:339-352. [PMID: 39895504 DOI: 10.1111/aor.14941] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/11/2024] [Accepted: 12/23/2024] [Indexed: 02/04/2025]
17
Safarikia S, Cirelli R, Spagnoletti G, Martinelli D, Bravetti G, Francalanci P, D'Alessandro A, Di Felice G, Maistri M, Baldissone E, Fratti AM, Simeoli R, Sacchetti E, Cairoli S, Rizzo C, Pariante R, Vacca M, Cappoli A, Albano C, Pietrobattista A, Spada M, Vici CD. Normothermic Machine Perfusion of Explanted Human Metabolic Livers: A Proof of Concept for Studying Inborn Errors of Metabolism. J Inherit Metab Dis 2025;48:e70010. [PMID: 40026238 PMCID: PMC11874047 DOI: 10.1002/jimd.70010] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/22/2024] [Revised: 01/13/2025] [Accepted: 02/04/2025] [Indexed: 03/05/2025]
18
Todd R, van Leeuwen LL, Holzner M, Kim-Schluger L, Fiel MI, Puleston D, Florman SS, Akhtar MZ. Normothermic machine perfusion of explanted livers: Exploratory study of an alternative translational model for end-stage liver disease. Artif Organs 2025;49:431-440. [PMID: 39578939 DOI: 10.1111/aor.14905] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/11/2024] [Revised: 09/08/2024] [Accepted: 11/01/2024] [Indexed: 11/24/2024]
19
Zarei S, Ghalichi F, Ahmadlouydarab M. Computational exploration of injection strategies for improving medicine distribution in the liver. Comput Biol Med 2025;185:109585. [PMID: 39729858 DOI: 10.1016/j.compbiomed.2024.109585] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/19/2024] [Revised: 11/24/2024] [Accepted: 12/13/2024] [Indexed: 12/29/2024]
20
Jeddou H, Tzedakis S, Chaouch MA, Sulpice L, Samson M, Boudjema K. Viability Assessment During Normothermic Machine Liver Perfusion: A Literature Review. Liver Int 2025;45:e16244. [PMID: 39821671 PMCID: PMC11740183 DOI: 10.1111/liv.16244] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/30/2024] [Revised: 12/25/2024] [Accepted: 01/03/2025] [Indexed: 01/19/2025]
21
Kim JJ, Kurial SNT, Choksi PK, Nunez M, Lunow-Luke T, Bartel J, Driscoll J, Her CL, Dhillon S, Yue W, Murti A, Mao T, Ramos JN, Tiyaboonchai A, Grompe M, Mattis AN, Syed SM, Wang BM, Maher JJ, Roll GR, Willenbring H. AAV capsid prioritization in normal and steatotic human livers maintained by machine perfusion. Nat Biotechnol 2025:10.1038/s41587-024-02523-6. [PMID: 39881029 DOI: 10.1038/s41587-024-02523-6] [Citation(s) in RCA: 1] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/17/2023] [Accepted: 12/02/2024] [Indexed: 01/31/2025]
22
Cillo U, Lonati C, Bertacco A, Magnini L, Battistin M, Borsetto L, Dazzi F, Al-Adra D, Gringeri E, Bacci ML, Schlegel A, Dondossola D. A proof-of-concept study in small and large animal models for coupling liver normothermic machine perfusion with mesenchymal stromal cell bioreactors. Nat Commun 2025;16:283. [PMID: 39746966 PMCID: PMC11697227 DOI: 10.1038/s41467-024-55217-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/24/2023] [Accepted: 12/03/2024] [Indexed: 01/04/2025]  Open
23
Ly M, Lau NS, Dennis C, Chen J, Risbey C, Tan S, Chen R, Wang C, Gorrell MD, McKenzie C, Kench JG, Liu K, McCaughan GW, Crawford M, Pulitano C. Long-term ex situ normothermic machine perfusion allows regeneration of human livers with severe bile duct injury. Am J Transplant 2025;25:60-71. [PMID: 39059585 DOI: 10.1016/j.ajt.2024.07.019] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/11/2024] [Revised: 06/28/2024] [Accepted: 07/15/2024] [Indexed: 07/28/2024]
24
Lan T, Yu M, Ming T, Wang H, Deng J, Cheng S, Shen Z, Kong D. A novel cytoprotective organ perfusion platform for reconstructing homeostasis of DCD liver while alleviating IRI injury. Bioeng Transl Med 2025;10:e10724. [PMID: 39801755 PMCID: PMC11711209 DOI: 10.1002/btm2.10724] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/31/2024] [Revised: 07/21/2024] [Accepted: 09/06/2024] [Indexed: 01/16/2025]  Open
25
De Carlis R, Lauterio A, Schlegel A, Gringeri E, Patrono D, Camagni S, Dondossola D, Pezzati D, Olivieri T, Pagano D, Bongini M, Montanelli P, Ravaioli M, Bernasconi D, Valsecchi MG, Baccarani U, Cescon M, Andorno E, Mazzaferro V, Gruttadauria S, Di Benedetto F, Ghinolfi D, Caccamo L, Pinelli D, Romagnoli R, Cillo U, De Carlis L. Are there any benefits of prolonged hypothermic oxygenated perfusion?: Results from a national retrospective study. Liver Transpl 2025;31:70-84. [PMID: 39287560 DOI: 10.1097/lvt.0000000000000476] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/14/2024] [Accepted: 08/11/2024] [Indexed: 09/19/2024]
26
Shishido Y, Tracy KM, Petrovic M, Adesanya T, Fortier AK, Raietparvar K, Glomp GA, Simonds E, Harris TR, Simon V, Tucker WD, Petree B, Cortelli M, Cardwell NL, Crannell C, Liang J, Murphy AC, Fields BL, McReynolds M, Demarest CT, Ukita R, Rizzari M, Montenovo M, Magliocca JF, Karp SJ, Rauf MA, Shah AS, Bacchetta M. Novel Dynamic Organ Storage System Enhances Liver Graft Function in a Porcine Donation After Circulatory Death Model. ASAIO J 2024:00002480-990000000-00611. [PMID: 39693205 DOI: 10.1097/mat.0000000000002365] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/20/2024]  Open
27
Lascaris B, Nijsten MWN, de Meijer VE. No need for complex blood purification systems for renal replacement therapy during long-term liver normothermic machine perfusion. J Hepatol 2024;81:e287-e289. [PMID: 38879171 DOI: 10.1016/j.jhep.2024.06.009] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/30/2024] [Revised: 06/06/2024] [Accepted: 06/06/2024] [Indexed: 11/19/2024]
28
Risbey CWG, Lau NS, Pulitano C. The importance of developing viability criteria to assess liver grafts undergoing multi-week normothermic perfusion. J Hepatol 2024;81:e290-e291. [PMID: 39038549 DOI: 10.1016/j.jhep.2024.07.013] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/03/2024] [Revised: 07/15/2024] [Accepted: 07/15/2024] [Indexed: 07/24/2024]
29
Jiao X, Li Y, Chen Z, Zhang Q, He R, Huang Y, Zuo Z. Targeting the PDE3B-cAMP-autophagy axis prevents liver injury in long-term supercooling liver preservation. Sci Transl Med 2024;16:eadk0636. [PMID: 39602509 DOI: 10.1126/scitranslmed.adk0636] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/31/2023] [Revised: 05/11/2024] [Accepted: 11/01/2024] [Indexed: 11/29/2024]
30
Lau NS, McCaughan G, Ly M, Liu K, Crawford M, Pulitano C. Long-term machine perfusion of human split livers: a new model for regenerative and translational research. Nat Commun 2024;15:9809. [PMID: 39532864 PMCID: PMC11557707 DOI: 10.1038/s41467-024-54024-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/30/2024] [Accepted: 10/30/2024] [Indexed: 11/16/2024]  Open
31
Li Z, Pfister M, Huwyler F, Hoffmann W, Tibbitt MW, Dutkowski P, Clavien PA. Revolutionizing Liver Transplantation: Transitioning to an Elective Procedure Through Ex Situ Normothermic Machine Perfusion - A Benefit Analysis. Ann Surg 2024;280:887-895. [PMID: 39077782 DOI: 10.1097/sla.0000000000006462] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 07/31/2024]
32
Cywes C, Banker A, Muñoz N, Levine M, Abu-Gazala S, Bittermann T, Abt P. The Potential Utilization of Machine Perfusion to Increase Transplantation of Macrosteatotic Livers. Transplantation 2024;108:e370-e375. [PMID: 38773856 DOI: 10.1097/tp.0000000000005057] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 05/24/2024]
33
Purssell A, Kumar D. Impact of machine perfusion on transplant infectious diseases: New challenges and opportunities. Transpl Infect Dis 2024;26 Suppl 1:e14348. [PMID: 39078339 DOI: 10.1111/tid.14348] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/01/2024] [Revised: 06/30/2024] [Accepted: 07/09/2024] [Indexed: 07/31/2024]
34
Lascaris B, Bodewes SB, Adelmeijer J, Nijsten MWN, Porte RJ, de Meijer VE, Lisman T. Production of physiological amounts of hemostatic proteins by human donor livers during ex situ long-term normothermic machine perfusion for up to 7 days. J Thromb Haemost 2024;22:3097-3106. [PMID: 39173880 DOI: 10.1016/j.jtha.2024.08.004] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/28/2024] [Revised: 07/06/2024] [Accepted: 08/01/2024] [Indexed: 08/24/2024]
35
Hosgood SA, Nicholson ML. Current Basic Research in Normothermic Machine Perfusion. Eur Surg Res 2024;65:137-145. [PMID: 39471796 DOI: 10.1159/000542290] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/15/2024] [Accepted: 10/24/2024] [Indexed: 11/01/2024]
36
Ozgur OS, Taggart M, Mojoudi M, Pendexter C, Filz von Reiterdank I, Kharga A, Yeh H, Toner M, Longchamp A, Tessier SN, Uygun K. Optimized partial freezing protocol enables 10-day storage of rat livers. Sci Rep 2024;14:25260. [PMID: 39448774 PMCID: PMC11502795 DOI: 10.1038/s41598-024-76674-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/14/2024] [Accepted: 10/16/2024] [Indexed: 10/26/2024]  Open
37
Clarke G, Mao J, Hann A, Fan Y, Gupta A, Nutu A, Buckel Schaffner E, Kayani K, Murphy N, Bangash MN, Casey AL, Wootton I, Lawson AJ, Dasari BVM, Perera MTPR, Mergental H, Afford SC. A reproducible extended ex-vivo normothermic machine liver perfusion protocol utilising improved nutrition and targeted vascular flows. COMMUNICATIONS MEDICINE 2024;4:214. [PMID: 39448795 PMCID: PMC11502869 DOI: 10.1038/s43856-024-00636-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/17/2024] [Accepted: 10/09/2024] [Indexed: 10/26/2024]  Open
38
Guo Z, Yin M, Sun C, Xu G, Wang T, Jia Z, Zhang Z, Zhu C, Zheng D, Wang L, Huang S, Liu D, Zhang Y, Xie R, Gao N, Zhan L, He S, Zhu Y, Li Y, Nashan B, Andrea S, Xu J, Zhao Q, He X. Liver protects neuron viability and electrocortical activity in post-cardiac arrest brain injury. EMBO Mol Med 2024;16:2322-2348. [PMID: 39300235 PMCID: PMC11479250 DOI: 10.1038/s44321-024-00140-z] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/24/2024] [Revised: 07/18/2024] [Accepted: 08/14/2024] [Indexed: 09/22/2024]  Open
39
Uygun K, von Reiterdank IF, Mojoudi M, Bento R, Taggart M, Dinicu A, Wojtkiewicz G, Coert J, van der Molen AM, Weissleder R, Parekkadan B. Ex Vivo Machine Perfusion as a Platform for Lentiviral Gene Delivery in Rat Livers. RESEARCH SQUARE 2024:rs.3.rs-4784505. [PMID: 39315250 PMCID: PMC11419271 DOI: 10.21203/rs.3.rs-4784505/v1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 09/25/2024]
40
Zhao Q, Li J, Lin Z, Tang Y, Yang D, Qin M, Ma X, Ji H, Chen H, Wang T, Chen M, Ju W, Wang D, Guo Z, Zhu X, Dan J, Hu A, He X. The First Case of Intra-portal Islet Implantation During Liver Machine Perfusion Allowing Simultaneous Islet-liver Transplantation in A Human: A New and Safe Treatment for End-stage Liver Disease Combined With Diabetes Mellitus. Ann Surg 2024;281:00000658-990000000-01066. [PMID: 39247951 PMCID: PMC11723485 DOI: 10.1097/sla.0000000000006526] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 09/10/2024]
41
Alnagar AM, Hajibandeh S, Hajibandeh S, Hakeem AR, Dasari BV. Impact of Donor Obesity on Graft and Recipient Survival Outcomes After Liver Transplantation: A Systematic Review and Meta-analysis. Transplant Direct 2024;10:e1656. [PMID: 39220221 PMCID: PMC11365672 DOI: 10.1097/txd.0000000000001656] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/14/2024] [Revised: 03/17/2024] [Accepted: 03/26/2024] [Indexed: 09/04/2024]  Open
42
Cillo U, Nalesso F, Bertacco A, Indraccolo S, Gringeri E. Normothermic perfusion of a human tumoral liver for 17 days with concomitant extracorporeal blood purification therapy: Case description. J Hepatol 2024;81:e96-e98. [PMID: 38703827 DOI: 10.1016/j.jhep.2024.04.024] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 04/02/2024] [Revised: 04/16/2024] [Accepted: 04/17/2024] [Indexed: 05/06/2024]
43
Feng S, Roll GR, Rouhani FJ, Sanchez Fueyo A. The future of liver transplantation. Hepatology 2024;80:674-697. [PMID: 38537154 DOI: 10.1097/hep.0000000000000873] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/26/2024] [Accepted: 03/02/2024] [Indexed: 06/15/2024]
44
Berg T, Aehling NF, Bruns T, Welker MW, Weismüller T, Trebicka J, Tacke F, Strnad P, Sterneck M, Settmacher U, Seehofer D, Schott E, Schnitzbauer AA, Schmidt HH, Schlitt HJ, Pratschke J, Pascher A, Neumann U, Manekeller S, Lammert F, Klein I, Kirchner G, Guba M, Glanemann M, Engelmann C, Canbay AE, Braun F, Berg CP, Bechstein WO, Becker T, Trautwein C. [Not Available]. ZEITSCHRIFT FUR GASTROENTEROLOGIE 2024;62:1397-1573. [PMID: 39250961 DOI: 10.1055/a-2255-7246] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 09/11/2024]
45
Zhao Q, Wang X, Liu K, Chen H, Dan J, Zhu Z, Guo L, Chen H, Ju W, Wang D, Tang Y, Guo Z, He X. Activation of farnesoid X receptor enhances the efficacy of normothermic machine perfusion in ameliorating liver ischemia-reperfusion injury. Am J Transplant 2024;24:1610-1622. [PMID: 38615902 DOI: 10.1016/j.ajt.2024.04.003] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/14/2023] [Revised: 03/11/2024] [Accepted: 04/04/2024] [Indexed: 04/16/2024]
46
Lei C, Li Z, Ma S, Zhang Q, Guo J, Ouyang Q, Lei Q, Zhou L, Yang J, Lin J, Ettlinger R, Wuttke S, Li X, Brinker CJ, Zhu W. Improving normothermic machine perfusion and blood transfusion through biocompatible blood silicification. Proc Natl Acad Sci U S A 2024;121:e2322418121. [PMID: 39159377 PMCID: PMC11363281 DOI: 10.1073/pnas.2322418121] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/22/2023] [Accepted: 07/11/2024] [Indexed: 08/21/2024]  Open
47
Zhang IW, Lurje I, Lurje G, Knosalla C, Schoenrath F, Tacke F, Engelmann C. Combined Organ Transplantation in Patients with Advanced Liver Disease. Semin Liver Dis 2024;44:369-382. [PMID: 39053507 PMCID: PMC11449526 DOI: 10.1055/s-0044-1788674] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 07/27/2024]
48
Patrono D, De Stefano N, Vissio E, Gambella A, Romagnoli R. Long-term normothermic machine perfusion of fatty livers: towards transplanting untransplantable livers? Hepatobiliary Surg Nutr 2024;13:681-685. [PMID: 39175741 PMCID: PMC11336520 DOI: 10.21037/hbsn-24-285] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/20/2024] [Accepted: 06/20/2024] [Indexed: 08/24/2024]
49
Groen PC, van Leeuwen OB, de Jonge J, Porte RJ. Viability assessment of the liver during ex-situ machine perfusion prior to transplantation. Curr Opin Organ Transplant 2024;29:239-247. [PMID: 38764406 PMCID: PMC11224566 DOI: 10.1097/mot.0000000000001152] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 05/21/2024]
50
Ozgur OS, Taggart MS, Mojoudi M, Pendexter C, Kharga A, Yeh H, Toner M, Longchamp A, Tessier SN, Uygun K. Optimized Partial Freezing Protocol Enables 10-Day Storage of Rat Livers. RESEARCH SQUARE 2024:rs.3.rs-4584242. [PMID: 39011100 PMCID: PMC11247935 DOI: 10.21203/rs.3.rs-4584242/v1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 07/17/2024]
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