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For: Cox AD, Fesik SW, Kimmelman AC, Luo J, Der CJ. Drugging the undruggable RAS: Mission possible? Nat Rev Drug Discov. 2014;13:828-851. [PMID: 25323927 DOI: 10.1038/nrd4389] [Citation(s) in RCA: 1447] [Impact Index Per Article: 131.5] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/06/2023]
Number Cited by Other Article(s)
1
Tian H, Zeng W, Wang Z, Li S, Wei W, Li S, Yin X, Na W, Wang Y, Song K, Zhu P, Liang W. P-Pev: micelle-like complexes transformed from tumor extracellular vesicles by PEG-PE for personalized therapeutic tumor vaccine. Biomaterials 2025;321:123333. [PMID: 40239595 DOI: 10.1016/j.biomaterials.2025.123333] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/06/2024] [Revised: 02/18/2025] [Accepted: 04/07/2025] [Indexed: 04/18/2025]
2
Li L, Liu Q, Shao Y, Wang S, Liu S, Wang X, Wang S, Ren D. Gaudichaudion H inhibits KRAS-mutant pancreatic cancer cell growth through interfering PDEδ-KRAS interaction. Chem Biol Interact 2025;415:111529. [PMID: 40288433 DOI: 10.1016/j.cbi.2025.111529] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/28/2024] [Revised: 04/03/2025] [Accepted: 04/25/2025] [Indexed: 04/29/2025]
3
Wu J, Jiang S, Shen Q, Gong H. Postoperative metastatic Krukenberg tumors with ARID1A and KRAS mutations in a patient with gastric cancer treated with oxaliplatin and tegafur: A case report. Oncol Lett 2025;29:262. [PMID: 40230423 PMCID: PMC11995681 DOI: 10.3892/ol.2025.15008] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/13/2024] [Accepted: 03/14/2025] [Indexed: 04/16/2025]  Open
4
Hwang SY, Seo Y, Park S, Kim SA, Moon I, Liu Y, Kim S, Pak ES, Jung S, Kim H, Jeon KH, Seo SH, Sung I, Lee H, Park SY, Na Y, Kim TI, Kwon Y. Targeting the HER2-ELF3-KRAS axis: a novel therapeutic strategy for KRASG13D colorectal cancer. Mol Cancer 2025;24:139. [PMID: 40340861 PMCID: PMC12063335 DOI: 10.1186/s12943-025-02343-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/19/2024] [Accepted: 04/25/2025] [Indexed: 05/10/2025]  Open
5
Ji X, Li H, Wu G, Zhang Q, He X, Wu Y, Zong B, Xu X, Liang C, Wang B, Zhang Y, Hu Q, Deng C, Shen L, Chen Z, Bai B, Wang L, Ai J, Zhang L, Zhou H, Sun S, Wang Y, Wang Y, Fan Q, Chen D, Zhou T, Kong X, Lu J. Discovery and Characterization of RP03707: A Highly Potent and Selective KRASG12D PROTAC. J Med Chem 2025. [PMID: 40338735 DOI: 10.1021/acs.jmedchem.5c00428] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 05/10/2025]
6
Sirocchi LS, Scharnweber M, Oberndorfer S, Siszler G, Zak KM, Rumpel K, Neumüller RA, Wilding B. Discovery of Carbodiimide Warheads to Selectively and Covalently Target Aspartic Acid in KRASG12D. J Am Chem Soc 2025;147:15787-15795. [PMID: 40267480 DOI: 10.1021/jacs.5c03562] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 04/25/2025]
7
Krauß D, Moreno-Viedma V, Adachi-Fernandez E, de Sá Fernandes C, Genger JW, Fari O, Blauensteiner B, Kirchhofer D, Bradaric N, Gushchina V, Fotakis G, Mohr T, Abramovich I, Mor I, Holcmann M, Bergthaler A, Haschemi A, Trajanoski Z, Winkler J, Gottlieb E, Sibilia M. EGFR controls transcriptional and metabolic rewiring in KRASG12D colorectal cancer. EMBO Mol Med 2025:10.1038/s44321-025-00240-4. [PMID: 40329096 DOI: 10.1038/s44321-025-00240-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/16/2024] [Revised: 03/26/2025] [Accepted: 04/02/2025] [Indexed: 05/08/2025]  Open
8
Xie L, Luo D, Chen X, Zhang M, Zhang W, Chang J, Zhou H, Zhang X, He J, Chen L, Zhou C. RAS gene polymorphisms confer the risk of neuroblastoma in Chinese children from Jiangsu province. Pediatr Surg Int 2025;41:130. [PMID: 40323475 DOI: 10.1007/s00383-025-06025-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 04/11/2025] [Indexed: 05/07/2025]
9
Mateo-Victoriano B, Samaranayake GJ, Pokharel S, Sahayanathan GJ, Jayaraj C, Troccoli CI, Watson DC, Mohsen MG, Guo Y, Kool ET, Rai P. Oncogenic KRAS addiction states differentially influence MTH1 expression and 8-oxodGTPase activity in lung adenocarcinoma. Redox Biol 2025;82:103610. [PMID: 40184641 PMCID: PMC11999683 DOI: 10.1016/j.redox.2025.103610] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/30/2024] [Revised: 03/11/2025] [Accepted: 03/21/2025] [Indexed: 04/07/2025]  Open
10
Ueki Y, Naylor RM, Ghozy SA, Thirupathi K, Rinaldo L, Kallmes DF, Kadirvel R. Advances in sporadic brain arteriovenous malformations: Novel genetic insights, innovative animal models and emerging therapeutic approaches. J Cereb Blood Flow Metab 2025;45:793-799. [PMID: 39948029 PMCID: PMC11826813 DOI: 10.1177/0271678x251319913] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/10/2024] [Revised: 01/27/2025] [Accepted: 01/27/2025] [Indexed: 02/16/2025]
11
Song H, Wang G, Gao G, Xia H, Jiao L, Wu K. A Systematic Analysis of Expression and Function of RAS GTPase-Activating Proteins (RASGAPs) in Urological Cancers: A Mini-Review. Cancers (Basel) 2025;17:1485. [PMID: 40361412 PMCID: PMC12071082 DOI: 10.3390/cancers17091485] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/05/2025] [Revised: 04/14/2025] [Accepted: 04/25/2025] [Indexed: 05/15/2025]  Open
12
Wang X, Ding L, Sun S, Loo SK, Chen L, Li T, Wang MT, Pennathur A, Huang Y, Gao SJ. CASTOR1 : A Novel Tumor Suppressor Linking mTORC1 and KRAS Pathways in Tumorigenesis and Resistance to KRAS-Targeted Therapies in Non-Small Cell Lung Cancer. BIORXIV : THE PREPRINT SERVER FOR BIOLOGY 2025:2025.04.23.650349. [PMID: 40313924 PMCID: PMC12045348 DOI: 10.1101/2025.04.23.650349] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 05/03/2025]
13
Xu H, Yao Q, Hu X, Zheng D, Ren C, Ren Z, Gao Y. On-Membrane Supramolecular Assemblies Serving as Bioorthogonal Gating for Melphalan. Angew Chem Int Ed Engl 2025:e202502922. [PMID: 40272883 DOI: 10.1002/anie.202502922] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/05/2025] [Revised: 04/24/2025] [Accepted: 04/24/2025] [Indexed: 05/04/2025]
14
El Zaitouni S, Laraqui A, Boustany Y, Benmokhtar S, El Annaz H, Abi R, Tagajdid MR, El Kochri S, Bouaiti EA, Amine IL, Ameziane El Hassani R, Ennibi K. Potency and Safety of KRAS G12C Inhibitors in Solid Tumors: A Systematic Review. Clin Med Insights Oncol 2025;19:11795549251331759. [PMID: 40297021 PMCID: PMC12035108 DOI: 10.1177/11795549251331759] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/19/2024] [Accepted: 03/13/2025] [Indexed: 04/30/2025]  Open
15
Kim HN, Gasmi-Seabrook GMC, Uchida A, Gebregiworgis T, Marshall CB, Ikura M. Switch II Pocket Inhibitor Allosterically Freezes KRASG12D Nucleotide-binding Site and Arrests the GTPase Cycle. J Mol Biol 2025;437:169162. [PMID: 40268231 DOI: 10.1016/j.jmb.2025.169162] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/17/2025] [Revised: 04/14/2025] [Accepted: 04/15/2025] [Indexed: 04/25/2025]
16
Li X, Mendez Q, Chapados C, Acca F, Driscoll H, Oliveira J, Liu J, Jones K, Ferguson M, Wallace RL, Bibikov S, Lionberger T, Harvey KJ, Weiner MP, Mirando G. Site-directed antibodies targeting driver mutations of the KRAS protein. N Biotechnol 2025;87:112-120. [PMID: 40252917 DOI: 10.1016/j.nbt.2025.04.003] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/20/2024] [Revised: 03/14/2025] [Accepted: 04/05/2025] [Indexed: 04/21/2025]
17
Scott E, Yun SD, Moghadamchargari Z, Bahramimoghaddam H, Chang JY, Zhang T, Zhu Y, Lyu J, Laganowsky A. Real time characterization of the MAPK pathway using native mass spectrometry. Commun Biol 2025;8:617. [PMID: 40240517 PMCID: PMC12003711 DOI: 10.1038/s42003-025-08028-5] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/04/2024] [Accepted: 04/01/2025] [Indexed: 04/18/2025]  Open
18
Yuan T, Liu Y, Wu R, Qian M, Wang W, Li Y, Zhu H, Wang J, Ge F, Zeng C, Dai X, Hu R, Zhou T, He Q, Zhu H, Yang B. Josephin Domain Containing 2 (JOSD2) inhibition as Pan-KRAS-mutation-targeting strategy for colorectal cancer. Nat Commun 2025;16:3623. [PMID: 40240366 PMCID: PMC12003847 DOI: 10.1038/s41467-025-58923-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/30/2024] [Accepted: 04/07/2025] [Indexed: 04/18/2025]  Open
19
Hashimoto Y, Shil S, Tsuruta M, Kawauchi K, Miyoshi D. Three- and four-stranded nucleic acid structures and their ligands. RSC Chem Biol 2025;6:466-491. [PMID: 40007865 PMCID: PMC11848209 DOI: 10.1039/d4cb00287c] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/26/2024] [Accepted: 02/18/2025] [Indexed: 02/27/2025]  Open
20
Ji X, Liu M, Zhang T, Zhang W, Xue F, Wan Q, Liu Y. KRAS/PI3K axis driven GTF3C6 expression and promotes LUAD via FAK pathway. J Adv Res 2025;70:243-254. [PMID: 38685529 PMCID: PMC11976405 DOI: 10.1016/j.jare.2024.04.028] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/04/2023] [Revised: 04/24/2024] [Accepted: 04/26/2024] [Indexed: 05/02/2024]  Open
21
Dissanayake UC, Roy A, Maghsoud Y, Polara S, Debnath T, Cisneros GA. Computational studies on the functional and structural impact of pathogenic mutations in enzymes. Protein Sci 2025;34:e70081. [PMID: 40116283 PMCID: PMC11926659 DOI: 10.1002/pro.70081] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/08/2024] [Revised: 01/23/2025] [Accepted: 02/12/2025] [Indexed: 03/23/2025]
22
Cregg J, Edwards AV, Chang S, Lee BJ, Knox JE, Tomlinson ACA, Marquez A, Liu Y, Freilich R, Aay N, Wang Y, Jiang L, Jiang J, Wang Z, Flagella M, Wildes D, Smith JAM, Singh M, Wang Z, Gill AL, Koltun ES. Discovery of Daraxonrasib (RMC-6236), a Potent and Orally Bioavailable RAS(ON) Multi-selective, Noncovalent Tri-complex Inhibitor for the Treatment of Patients with Multiple RAS-Addicted Cancers. J Med Chem 2025;68:6064-6083. [PMID: 40056080 DOI: 10.1021/acs.jmedchem.4c02314] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/28/2025]
23
Baars B, Orive-Ramos A, Kou Z, Gaire B, Desaunay M, Adamopoulos C, Aaronson SA, Wang S, Gavathiotis E, Poulikakos PI. RAS mutation-specific signaling dynamics in response to paralog- and state- selective RAS inhibitors. BIORXIV : THE PREPRINT SERVER FOR BIOLOGY 2025:2025.02.14.638317. [PMID: 40166154 PMCID: PMC11956912 DOI: 10.1101/2025.02.14.638317] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 04/02/2025]
24
Zhou Y, Tao Q, Luo C, Chen J, Chen G, Sun J. Epacadostat Overcomes Cetuximab Resistance in Colorectal Cancer by Targeting IDO-Mediated Tryptophan Metabolism. Cancer Sci 2025. [PMID: 40103010 DOI: 10.1111/cas.70057] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/04/2025] [Revised: 03/06/2025] [Accepted: 03/12/2025] [Indexed: 03/20/2025]  Open
25
Schock Vaiani J, Broekgaarden M, Coll JL, Sancey L, Busser B. In vivo vectorization and delivery systems for gene therapies and RNA-based therapeutics in oncology. NANOSCALE 2025;17:5501-5525. [PMID: 39927415 DOI: 10.1039/d4nr05371k] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 02/11/2025]
26
Chen C, Wei Z. Mechanisms and molecular characterization of relapsed/refractory neuroblastomas. Front Oncol 2025;15:1555419. [PMID: 40115016 PMCID: PMC11922920 DOI: 10.3389/fonc.2025.1555419] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/04/2025] [Accepted: 02/18/2025] [Indexed: 03/22/2025]  Open
27
Ge Z, Fan Z, He W, Zhou G, Zhou Y, Zheng M, Zhang S. Recent advances in targeted degradation in the RAS pathway. Future Med Chem 2025;17:693-708. [PMID: 40065567 PMCID: PMC11938967 DOI: 10.1080/17568919.2025.2476387] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/26/2024] [Accepted: 02/12/2025] [Indexed: 03/26/2025]  Open
28
Kazi A, Vasiyani H, Ghosh D, Bandyopadhyay D, Shah RD, Vudatha V, Trevino J, Sebti SM. FGTI-2734 Inhibits ERK Reactivation to Overcome Sotorasib Resistance in KRAS G12C Lung Cancer. J Thorac Oncol 2025;20:331-344. [PMID: 39603412 PMCID: PMC11885004 DOI: 10.1016/j.jtho.2024.11.022] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/15/2024] [Revised: 10/09/2024] [Accepted: 11/20/2024] [Indexed: 11/29/2024]
29
Hu Z, Martí J. Unraveling atomic-scale mechanisms of GDP extraction catalyzed by SOS1 in KRAS-G12 and KRAS-D12 oncogenes. Comput Biol Med 2025;186:109599. [PMID: 39731920 DOI: 10.1016/j.compbiomed.2024.109599] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/02/2024] [Revised: 12/16/2024] [Accepted: 12/17/2024] [Indexed: 12/30/2024]
30
Chen L, Ning J, Linghu L, Tang J, Liu N, Long Y, Sun J, Lv C, Shi Y, Tao T, Xiao D, Cao Y, Wang X, Liu S, Li G, Zhang B, Tao Y. USP13 facilitates a ferroptosis-to-autophagy switch by activation of the NFE2L2/NRF2-SQSTM1/p62-KEAP1 axis dependent on the KRAS signaling pathway. Autophagy 2025;21:565-582. [PMID: 39360581 PMCID: PMC11849926 DOI: 10.1080/15548627.2024.2410619] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/01/2023] [Revised: 09/20/2024] [Accepted: 09/25/2024] [Indexed: 10/04/2024]  Open
31
Daya T, Breytenbach A, Gu L, Kaur M. Cholesterol metabolism in pancreatic cancer and associated therapeutic strategies. Biochim Biophys Acta Mol Cell Biol Lipids 2025;1870:159578. [PMID: 39542394 DOI: 10.1016/j.bbalip.2024.159578] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/24/2024] [Revised: 10/31/2024] [Accepted: 11/10/2024] [Indexed: 11/17/2024]
32
Deck SL, Xu M, Milano SK, Cerione RA. Revealing Functional Hotspots: Temperature-Dependent Crystallography of K-RAS Highlights Allosteric and Druggable Sites. BIORXIV : THE PREPRINT SERVER FOR BIOLOGY 2025:2025.02.27.639303. [PMID: 40060414 PMCID: PMC11888411 DOI: 10.1101/2025.02.27.639303] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Indexed: 03/15/2025]
33
Huang D, Manoni F, Sun Z, Liu R, Allen JR, Banerjee A, Cee VJ, Eshon J, Frohn MJ, Kaller MR, Lee H, Li C, Li X, Lopez P, Ma V, Medina JM, Mohr C, Mukhina OA, Pickrell AJ, Stellwagen J, Wu W, Zhang W, Zhu K, Dahal UP, Hu LA, Leavitt M, Li W, Li Y, Ma Y, Rex K, Saiki AY, Wang P, Sun Y, Dai D, Tamayo NA, Lanman BA. Identification of Structurally Novel KRASG12C Inhibitors through Covalent DNA-Encoded Library Screening. J Med Chem 2025;68:4801-4817. [PMID: 39930787 PMCID: PMC11873997 DOI: 10.1021/acs.jmedchem.4c03071] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/14/2024] [Revised: 01/25/2025] [Accepted: 01/28/2025] [Indexed: 02/28/2025]
34
Nussinov R, Yavuz BR, Jang H. Allostery in Disease: Anticancer Drugs, Pockets, and the Tumor Heterogeneity Challenge. J Mol Biol 2025:169050. [PMID: 40021049 DOI: 10.1016/j.jmb.2025.169050] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/31/2025] [Accepted: 02/24/2025] [Indexed: 03/03/2025]
35
Uniyal P, Kashyap VK, Behl T, Parashar D, Rawat R. KRAS Mutations in Cancer: Understanding Signaling Pathways to Immune Regulation and the Potential of Immunotherapy. Cancers (Basel) 2025;17:785. [PMID: 40075634 PMCID: PMC11899378 DOI: 10.3390/cancers17050785] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/06/2024] [Revised: 02/15/2025] [Accepted: 02/19/2025] [Indexed: 03/14/2025]  Open
36
Liu Z, Li Y, Wang S, Wang Y, Sui M, Liu J, Chen P, Wang J, Zhang Y, Dang C, Hou P. Genome-wide CRISPR screening identifies PHF8 as an effective therapeutic target for KRAS- or BRAF-mutant colorectal cancers. J Exp Clin Cancer Res 2025;44:70. [PMID: 40001243 PMCID: PMC11853609 DOI: 10.1186/s13046-025-03338-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/24/2024] [Accepted: 02/17/2025] [Indexed: 02/27/2025]  Open
37
Gupta T, Murtaza M. Advancing Targeted Therapies in Pancreatic Cancer: Leveraging Molecular Aberrations for Therapeutic Success. PROGRESS IN BIOPHYSICS AND MOLECULAR BIOLOGY 2025:S0079-6107(25)00016-1. [PMID: 39988056 DOI: 10.1016/j.pbiomolbio.2025.02.003] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/10/2024] [Revised: 02/03/2025] [Accepted: 02/20/2025] [Indexed: 02/25/2025]
38
Er Özilhan S, Efil SC, Çanakçı D, Ağaçkıran Y, Şener Dede D, Onak Kandemir N, Doğan M, Ünal TDK, Kıran MM, Kayaçetin S, Balta H, Tatlı Doğan H. Correlation of PD-L1 and HIF-1 Alpha Expression with KRAS Mutation and Clinicopathological Parameters in Non-Small Cell Lung Cancer. Curr Issues Mol Biol 2025;47:121. [PMID: 39996842 PMCID: PMC11854292 DOI: 10.3390/cimb47020121] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/22/2024] [Revised: 02/11/2025] [Accepted: 02/11/2025] [Indexed: 02/26/2025]  Open
39
Li A, Li S, Wang P, Dang C, Fan X, Chen M, Liu D, Li F, Liu H, Zhang W, Wang Y, Wang Y. Design, Structure Optimization, and Preclinical Characterization of JAB-21822, a Covalent Inhibitor of KRASG12C. J Med Chem 2025;68:2422-2436. [PMID: 39875337 DOI: 10.1021/acs.jmedchem.4c02939] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/30/2025]
40
Avădănei ER, Căruntu ID, Nucă I, Balan RA, Lozneanu L, Giusca SE, Pricope DL, Dascalu CG, Amalinei C. KRAS Mutation Status in Relation to Clinicopathological Characteristics of Romanian Colorectal Cancer Patients. Curr Issues Mol Biol 2025;47:120. [PMID: 39996841 PMCID: PMC11854687 DOI: 10.3390/cimb47020120] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/17/2024] [Revised: 02/06/2025] [Accepted: 02/09/2025] [Indexed: 02/26/2025]  Open
41
López-Estévez AM, Carrascal-Miniño A, Torres D, Alonso MJ, de Rosales RTM, Pellico J. Biodistribution of 89Zr-Radiolabeled Nanoassemblies for Monoclonal Antibody Delivery Revealed through In Vivo PET Imaging. ACS OMEGA 2025;10:4763-4773. [PMID: 39959112 PMCID: PMC11822718 DOI: 10.1021/acsomega.4c09823] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 10/28/2024] [Revised: 01/08/2025] [Accepted: 01/16/2025] [Indexed: 02/18/2025]
42
Kunimasa K, Aohara D, Nishino K. Driver mutation detected in cerebrospinal fluid despite negative liquid biopsy results. Discov Oncol 2025;16:145. [PMID: 39928192 PMCID: PMC11811313 DOI: 10.1007/s12672-025-01931-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/27/2024] [Accepted: 02/04/2025] [Indexed: 02/11/2025]  Open
43
Qin W, Liu Z, Huang M, Liang L, Gan Y, Huang Z, Huang J, Wei X. Recent Advances in Peptide Inhibitors Targeting Wild-Type Ras Protein Interactions in Cancer Therapy. Int J Mol Sci 2025;26:1425. [PMID: 40003893 PMCID: PMC11855556 DOI: 10.3390/ijms26041425] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/08/2024] [Revised: 01/24/2025] [Accepted: 01/26/2025] [Indexed: 02/27/2025]  Open
44
Chen R, He A, De Carvalho DD. Viral mimicry evasion: a new role for oncogenic KRAS mutations. Mol Oncol 2025;19:271-274. [PMID: 39592415 PMCID: PMC11792985 DOI: 10.1002/1878-0261.13771] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/04/2024] [Revised: 11/11/2024] [Accepted: 11/12/2024] [Indexed: 11/28/2024]  Open
45
Pandey D, Roy KK. Decoding KRAS dynamics: Exploring the impact of mutations and inhibitor binding. Arch Biochem Biophys 2025;764:110279. [PMID: 39710177 DOI: 10.1016/j.abb.2024.110279] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/05/2024] [Revised: 11/25/2024] [Accepted: 12/19/2024] [Indexed: 12/24/2024]
46
Kramer‐Drauberg M, Petrini E, Mira A, Patrucco E, Scardaci R, Savinelli I, Wang H, Qiao K, Carrà G, Nokin M, Zhou Z, Westover KD, Santamaria D, Porporato PE, Ambrogio C. Oncogenic mutant KRAS inhibition through oxidation at cysteine 118. Mol Oncol 2025;19:311-328. [PMID: 39838816 PMCID: PMC11793020 DOI: 10.1002/1878-0261.13798] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/09/2024] [Revised: 10/30/2024] [Accepted: 12/24/2024] [Indexed: 01/23/2025]  Open
47
Isermann T, Sers C, Der CJ, Papke B. KRAS inhibitors: resistance drivers and combinatorial strategies. Trends Cancer 2025;11:91-116. [PMID: 39732595 DOI: 10.1016/j.trecan.2024.11.009] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/26/2024] [Revised: 11/20/2024] [Accepted: 11/22/2024] [Indexed: 12/30/2024]
48
Fujiki K, Kakisawa Y, Mahmoud EM, Ueno Y. Synthesis and Application of 4'-C-[(N-alkyl)aminoethyl]thymidine Analogs for Optimizing Oligonucleotide Properties. Molecules 2025;30:581. [PMID: 39942684 PMCID: PMC11820600 DOI: 10.3390/molecules30030581] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/23/2024] [Revised: 01/20/2025] [Accepted: 01/24/2025] [Indexed: 02/16/2025]  Open
49
Takeda M, Yoshida S, Inoue T, Sekido Y, Hata T, Hamabe A, Ogino T, Miyoshi N, Uemura M, Yamamoto H, Doki Y, Eguchi H. The Role of KRAS Mutations in Colorectal Cancer: Biological Insights, Clinical Implications, and Future Therapeutic Perspectives. Cancers (Basel) 2025;17:428. [PMID: 39941797 PMCID: PMC11816235 DOI: 10.3390/cancers17030428] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/20/2024] [Revised: 01/17/2025] [Accepted: 01/23/2025] [Indexed: 02/16/2025]  Open
50
Rolim TDS, Sampaio ALF, Mazzei JL, Moreira DL, Siani AC. Synthesis, Bioproduction and Bioactivity of Perillic Acid-A Review. Molecules 2025;30:528. [PMID: 39942631 PMCID: PMC11820084 DOI: 10.3390/molecules30030528] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/06/2025] [Revised: 01/21/2025] [Accepted: 01/22/2025] [Indexed: 02/16/2025]  Open
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