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Adams A, Gandhi A, Friedmann P, Sarkar S, Rana B, Epplein M, Wilkens L, Huang BZ, In H. Racial/ethnic differences in risk factors for non-cardia gastric cancer: an analysis of the Multiethnic Cohort (MEC) Study. Cancer Causes Control 2025; 36:255-263. [PMID: 39509055 PMCID: PMC11928376 DOI: 10.1007/s10552-024-01934-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/12/2023] [Accepted: 10/21/2024] [Indexed: 11/15/2024]
Abstract
PURPOSE Gastric cancer (GC) incidence rates show notable differences by racial/ethnic groups in the US. We sought to determine whether stratification by race/ethnicity would reveal unique risk factors for development of non-cardia gastric cancer (NCGC) for US population. METHODS Analysis included 1,112 incident cases of NCGC and 190,883 controls from the Multiethnic Cohort Study, a prospective US cohort study that recruited individuals living in Hawaii and California, aged 45-75 years from 5 races/ethnicities. Descriptive analysis and Cox regression models examined the association of risk factors for GC and calculate hazard ratios for each race/ethnicity, adjusting for sociodemographic and dietary variables. RESULTS Increasing age and male sex were risk factors for NCGC for most race/ethnicities. Higher risk was associated with: GC family history for Latino and Japanese American individuals [HRs range from 1.75 to 1.98]; foreign-born for Japanese American individuals [HR: 1.52, 95% CI 1.11-2.09]; lower education for African American, Japanese American, and Native Hawaiian individuals [HRs range from 1.30 to 1.74]; daily alcohol consumption for African American individuals[HR: 1.56, 95% CI 1.04-2.35]; current smoking for Latino and Japanese American individuals [HRs range from 1.89 to 1.94]; sodium consumption in the highest quartile for White individuals [HR: 2.55, 95% CI 1.23-5.26] compared to the lowest quartile; fruit consumption in the 2nd, 3rd, and 4th highest quartile for Native Hawaiian individuals [HRs range from 2.19 to 2.60] compared to the lowest quartile; diabetes for African American individuals [HR: 1.79, 95% CI 1.21-2.64]; and gastric/duodenal ulcers for Native Hawaiian individuals [HR: 1.82, 95% CI 1.04-3.18]. CONCLUSION Analyses by racial/ethnic group revealed differing risk factors for NCGC. Increased knowledge of the varying pathways to GC can support personalized GC prevention strategies and risk stratification tools for early detection.
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Affiliation(s)
- Alexandra Adams
- Division of Surgical Oncology, Rutgers Cancer Institute, New Brunswick, NJ, USA
| | - Atish Gandhi
- Division of Surgical Oncology, Rutgers Cancer Institute, New Brunswick, NJ, USA
| | | | | | - Brijesh Rana
- Division of Surgical Oncology, Rutgers Cancer Institute, New Brunswick, NJ, USA
| | - Meira Epplein
- Department of Population Health Sciences, Duke University, Durham, NC, USA
| | - Lynne Wilkens
- University of Hawai'i Cancer Center, University of Hawai'i at Mānoa, Honolulu, USA
| | - Brian Z Huang
- Department of Population and Public Health Sciences at the Keck School of Medicine of USC, Los Angeles, USA
| | - Haejin In
- Division of Surgical Oncology, Rutgers Cancer Institute, New Brunswick, NJ, USA.
- Albert Einstein College of Medicine, Bronx, NY, USA.
- Department of Health, Behavior and Policy, Rutgers University, Piscataway, NJ, USA.
- Rutgers Cancer Institute of New Jersey, 195 Little Albany Street, New Brunswick, NJ, 08903, USA.
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Ding Q, Ma X, Zhang Z, Lu P, Liu M. Pooled and global burdens and trends of five common cancers attributable to diet in 204 countries and territories from 1990 to 2019: an analysis of the Global Burden of Disease Study. Eur J Cancer Prev 2024; 33:485-492. [PMID: 38568190 PMCID: PMC11446530 DOI: 10.1097/cej.0000000000000884] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/26/2023] [Accepted: 03/02/2024] [Indexed: 10/04/2024]
Abstract
OBJECTIVE Increasing evidence has shown that dietary behaviors are closely correlated with the carcinogenesis and progression of many types of cancer. However, few studies have assessed the global diet-related burden of cancer. This study aimed to estimate the pooled burdens and trends of five types of cancers attributable to dietary behaviors. METHODS Data regarding cancer attributable to dietary behaviors were extracted from the Global Burden of Disease study 2019, including the death cases and age-standardized death rates, and disability-adjusted life years (DALYs) estimated according to diseases, age, sex, the socio-demographic index (SDI) and location. RESULTS According to the Global Burden of Disease study 2019, five types of cancer were affected by dietary behaviors: colon and rectum cancer; tracheal, bronchus and lung cancer; stomach cancer; esophageal cancer and breast cancer. Unhealthy dietary behaviors for cancer caused a total of 605.4 thousand deaths and 13951.3 thousand DALYs globally. The burden of cancer attributable to dietary risks was higher for men than for women. The highest age-standardized death rates in 2019 were observed in southern Latin America, and the lowest rates were observed in North Africa and the Middle East. The greatest increases in the age-standardized death rates, from 1990 to 2019, were found in Western Sub-Saharan Africa, with the greatest decreases in Central Asia. The highest attributable proportions of death or DALYs were colon and rectum cancer. The greatest diet-related cancer burden was observed in regions with a high-middle SDI. CONCLUSION Global age-standardized deaths and DALYs rates attributable to diet-related cancer are considerable and cause a substantial burden. Successful population-wide initiatives targeting unhealthy dietary behaviors would reduce this burden.
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Affiliation(s)
- Qiang Ding
- Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan
| | - Xiaoli Ma
- Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan
- Department of Gastroenterology, People’s Hospital of Yuan’an County, Yichang City, Hubei Province, China
| | - Zerui Zhang
- Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan
| | - Panpan Lu
- Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan
| | - Mei Liu
- Department of Gastroenterology, Institute of Liver and Gastrointestinal Diseases, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan
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Effect of Dietary Salt Intake on Risk of Gastric Cancer: A Systematic Review and Meta-Analysis of Case-Control Studies. Nutrients 2022; 14:nu14204260. [PMID: 36296944 PMCID: PMC9609108 DOI: 10.3390/nu14204260] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/13/2022] [Revised: 10/01/2022] [Accepted: 10/03/2022] [Indexed: 02/07/2023] Open
Abstract
Aim: The effect of dietary salt intake on the risk of gastric cancer is not clear. A meta-analysis was performed to estimate the association between dietary salt intake and the risk of gastric cancer. Methods: Three major databases were searched to retrieve case-control studies published in English before 1 July 2022. Random effects model analysis was used to obtain the pooled odds ratios (ORs) and 95% confidence intervals (CIs) of the association between dietary salt intake and risk of gastric cancer. Subgroup analyses were used to identify possible sources of heterogeneity. Results: Thirty-eight case-control studies were included in this meta-analysis (total population: n = 37,225). The pooled ORs showed a significantly positive association between high salt intake and gastric cancer compared with low salt intake (OR = 1.55, 95% CI (1.45, 1.64); p < 0.001). In subgroup meta-analysis for geographic region, estimation method for dietary salt intake and the source of controls, this association was not changed. Conclusion: Higher dietary salt intake increased the risk of gastric cancer. This study has implications for the prevention of gastric cancer.
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Ioannou LG, Mantzios K, Tsoutsoubi L, Nintou E, Vliora M, Gkiata P, Dallas CN, Gkikas G, Agaliotis G, Sfakianakis K, Kapnia AK, Testa DJ, Amorim T, Dinas PC, Mayor TS, Gao C, Nybo L, Flouris AD. Occupational Heat Stress: Multi-Country Observations and Interventions. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2021; 18:6303. [PMID: 34200783 PMCID: PMC8296111 DOI: 10.3390/ijerph18126303] [Citation(s) in RCA: 47] [Impact Index Per Article: 11.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 04/11/2021] [Revised: 05/25/2021] [Accepted: 06/07/2021] [Indexed: 12/20/2022]
Abstract
BACKGROUND Occupational heat exposure can provoke health problems that increase the risk of certain diseases and affect workers' ability to maintain healthy and productive lives. This study investigates the effects of occupational heat stress on workers' physiological strain and labor productivity, as well as examining multiple interventions to mitigate the problem. METHODS We monitored 518 full work-shifts obtained from 238 experienced and acclimatized individuals who work in key industrial sectors located in Cyprus, Greece, Qatar, and Spain. Continuous core body temperature, mean skin temperature, heart rate, and labor productivity were collected from the beginning to the end of all work-shifts. RESULTS In workplaces where self-pacing is not feasible or very limited, we found that occupational heat stress is associated with the heat strain experienced by workers. Strategies focusing on hydration, work-rest cycles, and ventilated clothing were able to mitigate the physiological heat strain experienced by workers. Increasing mechanization enhanced labor productivity without increasing workers' physiological strain. CONCLUSIONS Empowering laborers to self-pace is the basis of heat mitigation, while tailored strategies focusing on hydration, work-rest cycles, ventilated garments, and mechanization can further reduce the physiological heat strain experienced by workers under certain conditions.
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Affiliation(s)
- Leonidas G. Ioannou
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
- Department of Nutrition, Exercise and Sports, August Krogh Building, University of Copenhagen, 2100 Copenhagen, Denmark;
| | - Konstantinos Mantzios
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
| | - Lydia Tsoutsoubi
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
| | - Eleni Nintou
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
| | - Maria Vliora
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
| | - Paraskevi Gkiata
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
| | - Constantinos N. Dallas
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
| | - Giorgos Gkikas
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
| | - Gerasimos Agaliotis
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
| | - Kostas Sfakianakis
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
| | - Areti K. Kapnia
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
| | - Davide J. Testa
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
| | - Tânia Amorim
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
| | - Petros C. Dinas
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
| | - Tiago S. Mayor
- SIMTECH Laboratory, Transport Phenomena Research Centre, Engineering Faculty of Porto University, 4200-465 Porto, Portugal;
| | - Chuansi Gao
- Thermal Environment Laboratory, Division of Ergonomics and Aerosol Technology, Department of Design Sciences, Faculty of Engineering, Lund University, 22100 Lund, Sweden;
| | - Lars Nybo
- Department of Nutrition, Exercise and Sports, August Krogh Building, University of Copenhagen, 2100 Copenhagen, Denmark;
| | - Andreas D. Flouris
- FAME Laboratory, Department of Physical Education and Sport Science, University of Thessaly, 42100 Trikala, Greece; (L.G.I.); (K.M.); (L.T.); (E.N.); (M.V.); (P.G.); (C.N.D.); (G.G.); (G.A.); (K.S.); (A.K.K.); (D.J.T.); (T.A.); (P.C.D.)
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Aghilinejad M, Kabir-Mokamelkhah E, Imanizade Z, Danesh H. Occupational Class Groups as a Risk Factor for Gastrointestinal Cancer: A Case-Control Study. THE INTERNATIONAL JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL MEDICINE 2017; 8:21-31. [PMID: 28051193 PMCID: PMC6679632 DOI: 10.15171/ijoem.2017.851] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Subscribe] [Scholar Register] [Received: 04/29/2016] [Accepted: 12/23/2016] [Indexed: 12/13/2022]
Abstract
BACKGROUND Cancer has a high mortality rate in both developing and developed countries. 11%-15% of cancers are attributable to occupational risk factors. OBJECTIVE To determine if specific occupational classes, based on the International Standard for Classification of Occupations 2008 (ISCO-08), are risk factors for gastrointestinal (GI) cancer. METHODS In this case-control study, 834 cancer patients were interviewed by a single physician. Cases included patients with GI cancer. Age-matched controls were selected from non-GI cancer patients. Each year of working, up until 5 years before the diagnosis, was questioned and categorized by the ISCO classification. RESULTS 243 GI cancer cases and 243 non-GI cancer patients (486 in total) were studied. Working in ISCO class 8 (plant and machine operators, and assemblers) was significantly associated with higher risk of GI cancer (OR 1.63, 95% CI 1.05 to 2.52). Working in ISCO class 6 (skilled agricultural, forestry and fishery workers) and 9 (elementary occupations) were also associated with higher incidence of GI cancers. CONCLUSION Working in ISCO classes of 8, 6, and 9, which are usually associated with low socio-economic status, can be considered a risk factor for GI cancers.
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Affiliation(s)
- Mashallah Aghilinejad
- Occupational Medicine Research Center (OMRC), Iran University of Medical Sciences and Health Services (IUMS), Tehran, Iran
| | - Elahe Kabir-Mokamelkhah
- Occupational Medicine Research Center (OMRC), Iran University of Medical Sciences and Health Services (IUMS), Tehran, Iran
| | - Zahra Imanizade
- Department of Occupational Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
| | - Hossein Danesh
- Department of Occupational Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran.
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Gamboa-Dominguez A, Ubbelohde T, Saqui-Salces M, Romano-Mazzoti L, Cervantes M, Domínguez-Fonseca C, de la Luz Estreber M, Ruíz-Palacios GM. Salt and stress synergize H. pylori-induced gastric lesions, cell proliferation, and p21 expression in Mongolian gerbils. Dig Dis Sci 2007; 52:1517-26. [PMID: 17404882 DOI: 10.1007/s10620-006-9524-3] [Citation(s) in RCA: 18] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/08/2006] [Accepted: 07/17/2006] [Indexed: 12/13/2022]
Abstract
Our aim was to determine if salt and stress enhance Helicobacter pylori (Hp) lesions in Meriones unguiculatus. Two hundred seventy-eight pathogen-free gerbils were allocated to seven groups: Hp-Sydney strain (45), 8% higher-salt diet (38), stress (60% space reduction/water immersion; 36), Hp + salt (33), Hp + stress (34), N-methyl-N-nitro-N-nitrosoguanidine (34), and sham (58). Gerbils were sacrificed at 1 week (67), 12 weeks (73), 52 weeks (65), and 68 weeks (73). Sydney, Padova, and Lauren classifications were blindly used. Proliferation, p53, p21, and apoptosis were assessed. Follicular active gastritis (grade 2/3) was observed in 10% of Hp gerbils, 38% of Hp + salt gerbils, and 29% of Hp + stress gerbils at 52 weeks and 67%, 83%, and 43% at 68 weeks (P < 0.05). Heterotopic proliferative glands were identified in synergy groups from 52 weeks, with increases in their number and size by 68 weeks. Higher proliferative rates were observed in Hp+salt gerbils (P < 0.0001), and p21 overexpression in Hp+salt and Hp+stress gerbils (both P's < 0.0001), by 68 weeks, without p53 increases. We conclude that salt and stress synergize Hp damage and increase pseudo-invasive gland foci.
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Affiliation(s)
- Armando Gamboa-Dominguez
- Department of Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubirán, Tlalpan, Mexico City, DF, Mexico.
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Abstract
Reliable data on familial risks are important for clinical counselling and cancer genetics. However, the estimates of familial risk of gastric cancer vary widely. We examined the risk of familial gastric cancer using the updated Swedish Family-Cancer Database with 5358 patients among offspring and 36 486 patients among parents. There were 133 families with one parent and one offspring diagnosed with gastric cancer, and 20 families with two affected offspring. Familial standardised incidence ratios (SIRs) were 1.63 and 2.93 when parents and siblings presented with gastric cancer, respectively. The high sibling risk was owing to cancer in the corpus (SIR 7.28). The SIR for cardia cancer was 1.54 when parents were diagnosed with any gastric cancer. Cardia cancer associated with oesophageal cancer, particularly with oesophageal adenocarcinoma. Among specific histologies, signet ring cancer showed an increase. A few associations were noted for discordant sites, including the urinary bladder and the endometrium. H. pylori infection, although not measured in the present study, is probably an important risk factor for the high sibling risk of corpus cancer. Familial clustering of cardia cancer is independent of H. pylori infection, and may have a genetic basis. The familial association of cardia cancer with oesophageal adenocarcinoma may provide aetiological clues.
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Affiliation(s)
- K Hemminki
- Center for Family and Community Medicine, Karolinska Institute, 141 83 Huddinge, Sweden
- Division of Molecular Genetic Epidemiology, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 580, 69120 Heidelberg, Germany
| | - J Sundquist
- Center for Family and Community Medicine, Karolinska Institute, 141 83 Huddinge, Sweden
| | - J Ji
- Center for Family and Community Medicine, Karolinska Institute, 141 83 Huddinge, Sweden
- E-mail:
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Ji J, Hemminki K. Socio-economic and occupational risk factors for gastric cancer: a cohort study in Sweden. Eur J Cancer Prev 2007; 15:391-7. [PMID: 16912567 DOI: 10.1097/00008469-200610000-00003] [Citation(s) in RCA: 17] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/02/2023]
Abstract
The effects of socio-economic/occupational factors on gastric cancer at various subsites (including corpus, cardia and unspecified cancers) are not well known. To investigate this issue, we carried out a follow-up study on the economically active Swedish population, based on the Swedish Family-Cancer Database. We calculated standardized incidence ratios and 95% confidence intervals for different occupational groups, adjusted for age, period, region and socio-economic status. The reference group was all the economically active population. Manual workers and farmers were at an increased risk of stomach cancer. An increased risk of corpus cancer was observed for male miners and quarry workers, fishermen, construction workers, packers, loaders and warehouse workers, clerical workers and female assistant nurses and postal workers. For cardia cancer, significantly increased standardized incidence ratios were observed for gardeners, transport workers, bricklayers and chemical process workers among men. Only male miner and quarry workers showed significantly increased risk of unspecified cancer. In conclusion, the present study indicates that socio-economic groups differ in risk by almost a factor of two for corpus and unspecified cancers, and less for cardia cancers. Cement and mineral dusts appear as major occupational risk factors.
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Affiliation(s)
- Jianguang Ji
- Department of Bioscience at Novum, Karolinska Institutet, Huddinge, Sweden.
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Sun J, Aoki K, Zheng JX, Su BZ, Ouyang XH, Misumi J. Effect of NaCl and Helicobacter pylori vacuolating cytotoxin on cytokine expression and viability. World J Gastroenterol 2006; 12:2174-80. [PMID: 16610017 PMCID: PMC4087642 DOI: 10.3748/wjg.v12.i14.2174] [Citation(s) in RCA: 15] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/06/2023] Open
Abstract
AIM: To determine whether Helicobacter pylori (H pylori) vacuolating cytotoxin (VacA) regulates release of pro-inflammatory cytokines (IL-1β, IL-8, TNF-α, and IL-6) or alters gastric epithelial cell viability and to determine whether NaCl affects these VacA-induced changes.
METHODS: Vacuolating activity was determined by measuring the uptake of neutral red into vacuoles of VacA-treated human gastric epithelial (AGS) cells. AGS cell viability was assessed by direct cell counting. Specific enzyme-linked immunosorbent assays (ELISA) and reverse transcriptase-polymerase chain reaction(RT-PCR) were performed to examine the effects of H pylori VacA and NaCl on cell pro-inflammatory cytokine production in AGS cells. Immunohistochemical staining of gastric tissue from Mongolian gerbils was used to confirm VacA-induced pro-inflammatory cytokine production and the effects of NaCl on this VacA-induced response.
RESULTS: Addition of VacA alone reduced AGS cell viability (P < 0.05), and this reduction was enhanced by high doses of NaCl (P < 0.05). VacA alone induced expression of TNF-α, IL-8 and IL-1β, while NaCl alone induced expression of TNF-α and IL-1β. Changes in mRNA levels in the presence of both VacA and NaCl were more complicated. For the case of TNF-α, expression was dose-dependent on NaCl. IL-6 mRNA was not detected. However, low levels of IL-6 were detected by ELISA. Positive immunohistochemical staining of IL-1, IL-6, and TNF-α was found in gastric tissue of H pylori-infected gerbils fed with either a normal diet or a high salt diet. However, the staining of these three cytokines was stronger in H pylori-infected animals fed with a 5g/kg NaCl diet.
CONCLUSION: VacA decreases the viability of AGS cells, and this effect can be enhanced by NaCl. NaCl also affects the production of pro-inflammatory cytokines induced by VacA, suggesting that NaCl plays an important role in H pylori-induced gastric epithelial cell cytotoxicity.
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Affiliation(s)
- Juan Sun
- Department of Public Health and Hygiene(II), Faculty of Medicine, Oita University Oita 879-5593, Japan
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