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DeGiovanni JC, Simmonds J, Lang-Orsini M, Lee A. Recurrent Intramuscular Hemangioma (Infiltrating Angiolipoma) of the Lower Lip: A Case Report and Review of the Literature. EAR, NOSE & THROAT JOURNAL 2020; 101:306-311. [PMID: 32921186 DOI: 10.1177/0145561320957759] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/17/2022] Open
Abstract
OBJECTIVE To report a case of a recurrent intramuscular hemangioma (IMH) of the lower lip of a 68-year-old female and review the published literature to provide an overview of the presentation, diagnostic strategy, pathological classification, and management of these lesions within the oral cavity. METHODS A case report was conducted by reviewing the documentation at a single institution. A systematic literature review on OVID MEDLINE and PubMed was performed using the MESH terms "intramuscular hemangioma" and "oral cavity," "tongue," "cheek," "buccal," "gingiva," and "lip." RESULTS A 62-year-old female presented to our institution with a 2 × 2 × 1 cm IMH of the lower lip involving the surrounding orbicularis oris muscle. She underwent a submucosal resection and did well postoperatively. Six and a half years later, she represented to our institution with a new lower lip lesion in the area of her previous resection. Preoperative magnetic resonance imaging showed a new 10 × 11 mm lesion with a well circumscribed central component surrounded by ill-defined tissue. Preoperative angiography showed that the lesion was supplied by vessels branching off the left facial artery, which were embolized. She underwent wide-local excision (WLE) with bilateral advancement flaps and at her 2-month postoperative visit has not had recurrence. CONCLUSION Only 39 cases of IMH in the oral cavity have been reported, with only 3 others occurring in the lower lip. Here we add the first case of an IMH of the oral cavity that recurred after primary WLE. The patient was successfully retreated with WLE. At a 3-month follow-up visit, she noted some incompetence with oral secretions and occasional tingling along the incision site but no evidence of recurrence.
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Affiliation(s)
| | | | | | - Arnold Lee
- Tufts University School of Medicine, Boston, MA, USA.,1867Tufts Medical Center, Boston, MA, USA
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Bhuyan SK, Bhuyan R, Debta P, Debta FM. Non-Infiltrating Angiolipoma of Floor of Mouth-A Rare Case Report and Literature Review. J Clin Diagn Res 2017; 11:ZD03-ZD05. [PMID: 28384985 DOI: 10.7860/jcdr/2017/22407.8964] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/29/2016] [Accepted: 09/12/2016] [Indexed: 11/24/2022]
Abstract
Angiolipoma, a subtype of lipoma is a benign tumour in which adipose tissue and vascular component are intermingled. The tumour occurs commonly in the trunk and extremities and very rarely seen in maxillofacial region. Here we report a case of Non-Infiltrating Angiolipoma (NIAL) in floor of mouth which is the second case to be reported in literature to the best of our knowledge. We have reviewed all NIAL cases involving the oral cavity from 2008 to 2016 and found 12 cases of NIAL and assessment was made according to age, sex, site and size of lesion for better understanding of the lesion and its nature.
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Affiliation(s)
- Sanat Kumar Bhuyan
- Professor and Head of Department, Department of Oral Medicine and Radiology, Institute of Dental Sciences , Bhubaneswar, Odisha, India
| | - Ruchi Bhuyan
- Professor, Department of Oral Pathology and Microbiology, Institute of Dental Sciences , Bhubaneswar, Odisha, India
| | - Priyanka Debta
- Reader, Department of Oral Pathology and Microbiology, Institute of Dental Sciences , Bhubaneswar, Odisha, India
| | - Fakir Mohan Debta
- Assistant Professor, Department of Oral Medicine, SCB Government Dental College , Cuttack, Odisha, India
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3
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Shahi AK, Ash H, Chatterji K, Singh R. Cellular infiltrative angiolipoma of cheek in an infant. Natl J Maxillofac Surg 2015; 5:202-5. [PMID: 25937736 PMCID: PMC4405967 DOI: 10.4103/0975-5950.154837] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/24/2022] Open
Abstract
Lipomas represent about 1 to 5% of all neoplasms of the oral cavity most commonly presenting as painless, mobile, soft, round mass. Angiolipoma, spindle cell lipoma, mylelolipoma, chondrolipoma and myxolipoma are histological variants of lipoma arising from fat tissues. Although the angiolipoma is the most common tumour in the trunk and the extrimities of young people, it occurs infrequently in the head and neck region. In this article we present clinical, radiological and histological features of a cellular infiltrative angiolipoma exicised from the buccal mucosa of a 9 months old female child.
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Affiliation(s)
- Ajoy Kumar Shahi
- Department of Oral and Maxillofacial Surgery, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India
| | - Hiralal Ash
- Department of Oral and Maxillofacial Surgery, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India
| | - Kabita Chatterji
- Department of Oral and Maxillofacial Pathology, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India
| | - Revati Singh
- Department of Oral and Maxillofacial Surgery, Buddha Institute of Dental Sciences and Hospital, Patna, Bihar, India
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4
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Ohnishi Y, Watanabe M, Fujii T, Yasui H, Kubo H, Kakudo K. Infiltrating angiolipoma of the lower lip: A case report and literature review. Oncol Lett 2014; 9:833-836. [PMID: 25621058 PMCID: PMC4301520 DOI: 10.3892/ol.2014.2737] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/14/2014] [Accepted: 09/08/2014] [Indexed: 01/04/2023] Open
Abstract
Infiltrating angiolipoma (IAL) is a rare lesion and is a clinicopathological variant of angiolipoma. IAL occurs most commonly in the trunk and extremities, it is rarely found in the head and neck regions and extremely rare in the oral cavity. This study presents the case of a 74-year-old female with IAL of the lower lip. To the best of our knowledge, this is the first case of IAL arising in the lower lip to be reported. Microscopically, IAL was unencapsulated and mature lipocytes were separated by a branching network of proliferating small vessels that infiltrated the adjacent tissues. Therefore, complete excision was difficult to perform. Magnetic resonance imaging has been reported to be valuable in determining the extent of the tumor and asserting a preoperative diagnosis. According to previous studies, the recurrence rate of IAL following surgical extirpation is 35–50%. Furthermore, the levels of mRNA expression of the vascular endothelial growth factor (VEGF) family members in the tumor were investigated. VEGF-A and -B expression were detected, however, VEGF-C and -D were expressed at extremely low levels. Excisional biopsy was performed under local anesthesia. During four years of follow-up, no evidence of tumor recurrence had been identified. An operating microscope may be utilized for the total removal of an IAL to minimize damage to normal tissues. This report indicates that mast cell-derived VEGF may be responsible for the enhanced vascularity in the tumor. We would therefore consider careful extirpation with no wide safety margin to be the procedure of choice, except when the tumor invades irregularly into the muscles.
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Affiliation(s)
- Yuichi Ohnishi
- Second Department of Oral and Maxillofacial Surgery, Osaka Dental University, Chuo-ku, Osaka 540-0008, Japan
| | - Masahiro Watanabe
- Second Department of Oral and Maxillofacial Surgery, Osaka Dental University, Chuo-ku, Osaka 540-0008, Japan
| | - Tomoko Fujii
- Second Department of Oral and Maxillofacial Surgery, Osaka Dental University, Chuo-ku, Osaka 540-0008, Japan
| | - Hiroki Yasui
- Second Department of Oral and Maxillofacial Surgery, Osaka Dental University, Chuo-ku, Osaka 540-0008, Japan
| | - Hirohito Kubo
- Second Department of Oral and Maxillofacial Surgery, Osaka Dental University, Chuo-ku, Osaka 540-0008, Japan
| | - Kenji Kakudo
- Second Department of Oral and Maxillofacial Surgery, Osaka Dental University, Chuo-ku, Osaka 540-0008, Japan
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5
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Prodromidis G, Chaniotis AM, Mitrou GG, Chatzistamou I, Tosios KI, Sklavounou A. A fluctuant swelling on the upper mucolabial fold. Oral Surg Oral Med Oral Pathol Oral Radiol 2014; 117:541-545. [DOI: 10.1016/j.oooo.2012.11.013] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/12/2012] [Revised: 10/01/2012] [Accepted: 11/26/2012] [Indexed: 12/26/2022]
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Silva-Junior GO, Picciani BL, Costa RC, Barbosa SM, Silvares MG, Souza RB, Cantisano MH, Pires FR. Oral soft-tissue angiolipoma: report of two cases of rare oral lipomatous lesion with emphasis on morphological and immunohistochemical features. J Oral Sci 2014; 55:85-8. [PMID: 23485606 DOI: 10.2334/josnusd.55.85] [Citation(s) in RCA: 8] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/01/2022]
Abstract
Oral angiolipomas are exceedingly rare and little is known about their morphological and etiological features. Here, we report two cases of oral angiolipoma and discuss their clinicopathological and immunohistochemical features, focusing on endothelial markers. Both lesions presented mature adipocytes interspersed by small blood vessels containing fibrin thrombi. Immunohistochemical analysis showed numerous mast cells and expression of CD34, vascular endothelial growth factor, intercellular adhesion molecule-1, interferon-γ and interleukin 6 in most endothelial and stromal cells. Mast cell-endothelial cell interaction may be responsible for the reactive or neoplastic origin of the vascular proliferation of these entities.
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Affiliation(s)
- Geraldo O Silva-Junior
- Department of Stomatology, School of Dentistry, State University of Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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7
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Angiolipoma in head and neck: report of two cases and review of the literature. Int J Oral Maxillofac Surg 2010; 39:610-5. [PMID: 20197228 DOI: 10.1016/j.ijom.2009.12.021] [Citation(s) in RCA: 19] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/20/2008] [Revised: 12/16/2009] [Accepted: 12/22/2009] [Indexed: 12/21/2022]
Abstract
Angiolipomas are either encapsulated or non-encapsulated fatty tumours. They are distinguished from other lipomas by the excessive degree of vascular proliferation and because they are mixed with mature adipocytes. They commonly occur in the trunk and extremities and are rare in the maxillofacial area. Only 36 cases in the head and neck have been reported in the literature. The authors report the first non-infiltrating intramasseterine angiolipoma, and a case of non-infiltrating angiolipoma of the cheek. These tumours appear as homogenous low-density areas on CT with no contrast enhancement. MRI gives better tumour delineation and clear definition of the location and longitudinal extent of the mass. Histopathology demonstrates mature adipose tissue and the proliferation of numerous small branching blood vessels. Management of angiolipomas requires complete surgical excision.
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Dalambiras S, Tilaveridis I, Iordanidis S, Zaraboukas T, Epivatianos A. Infiltrating angiolipoma of a the oral cavity: report of a case and literature review. J Oral Maxillofac Surg 2009; 68:681-3. [PMID: 19944512 DOI: 10.1016/j.joms.2009.04.131] [Citation(s) in RCA: 11] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/11/2008] [Accepted: 04/24/2009] [Indexed: 11/25/2022]
Affiliation(s)
- Stylianos Dalambiras
- Department of Oral and Maxillofacial Surgery, Dental School, University of Thessaloniki, Thessaloniki, Greece
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9
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Altug HA, Sahin S, Sencimen M, Dogan N, Erdogan O. Non-infiltrating angiolipoma of the cheek: a case report and review of the literature. J Oral Sci 2009; 51:137-9. [PMID: 19325211 DOI: 10.2334/josnusd.51.137] [Citation(s) in RCA: 19] [Impact Index Per Article: 1.2] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 12/11/2022]
Abstract
Angiolipoma, spindle cell lipoma, mylelolipoma, chondrolipoma and myxolipoma are histologic variants of lipomas arising from fat tissue. Although angiolipoma is the most common tumor in the trunk and extremities of young people, it occurs infrequently in the head and neck region. The authors present the clinical and histological features of a non-infiltrating angiolipoma excised from the cheek of a 22-year old man. Clinical examination showed a soft, mobile, approximately 4 x 3 cm mass that could be palpated anterior to the masseter muscle. The mass was removed by an intraoral approach. Angiolipoma was confirmed on histopathologic evaluation. Lipomas represent about 1 to 5% of all neoplasms of the oral cavity. They are usually painless, soft, round and mobile. The diagnosis is based on both clinical and histologic characteristics. The treatment is surgical excision.
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11
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Auo HJ, Kang JM. Infiltrating angiolipoma of the nasopharynx: adjacent to an aberrant internal carotid artery. Auris Nasus Larynx 2008; 36:247-50. [PMID: 18602235 DOI: 10.1016/j.anl.2008.05.004] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.4] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/03/2008] [Revised: 03/24/2008] [Accepted: 05/28/2008] [Indexed: 11/29/2022]
Abstract
Infiltrating angiolipomas are tumors consisting of adipose tissue marked by vascular proliferation and are nonencapsulated or partially encapsulated. These tumors are very rare in the head and neck. This is the first case report of infiltrating angiolipoma arising from the nasopharynx causing the Eustachian tube dysfunction. A 29-year-old female presented with a history of earfullness and nasal obstruction. A sessile mass was found at the left superior-lateral wall of the nasopharynx. The mass was excised by a transnasal endoscopic approach. The tumor was adhered to the cavernous sinus containing an aberrant internal carotid artery that was located in an abnormally low portion in the cavernous sinus. The patient is currently free of growth of remained tumor 4 years after endoscopic surgery.
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Affiliation(s)
- Hyeon-Jin Auo
- Department of Otolaryngology-Head and Neck Surgery, The Catholic University of Korea, Seoul, Republic of Korea
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12
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Maiorano E, Capodiferro S, Fanelli B, Calabrese L, Napoli A, Favia G. Hamartomatous angiolipoma of the parotid gland (sialoangiolipoma). Head Neck Pathol 2008; 2:36-40. [PMID: 20614340 PMCID: PMC2807606 DOI: 10.1007/s12105-007-0040-3] [Citation(s) in RCA: 10] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 08/30/2007] [Accepted: 12/14/2007] [Indexed: 01/18/2023]
Abstract
Mesenchymal tumors of the salivary glands are rare and mostly localized to the parotid gland. We report on the clinico-pathological features of a distinct parotid tumor occurred in a newborn, showing glandular structures admixed with mature lipocytes and blood vessels in variable proportions. This was a well-circumscribed and slowly growing nodule of the superficial parotid lobe, mostly reddish in color with white-yellowish striations. Microscopically, a distinct lobular architecture was evident, along with normal-appearing acinar and ductal structures with interposed loose fibrous stroma. The latter contained aggregates of mature lipocytes and variably sized blood vessels. The morphological features of the lesion reported herein recapitulate those of sialolipoma but also include the presence of a prominent vascular component intimately admixed with both the glandular and the adipose tissues. At variance with salivary lipoadenoma, the glandular component in the current case distinctly showed all the cellular components of normal salivary (serous) glands. In consideration of the young age of the patient, the minimal growth rate and the histological features of the lesion, we hypothesize a hamartomatous origin for this lesion and propose the designation of sialoangiolipoma.
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Affiliation(s)
- Eugenio Maiorano
- Department of Pathological Anatomy, University of Bari, Piazza G. Cesare, 11, Bari, 70124 Italy
| | | | - Benito Fanelli
- Division of Pediatric Surgery, Department of Surgery, “Giovanni XXIII” Paediatric Hospital, Bari, Italy
| | - Luca Calabrese
- Division of Head and Neck Surgery, European Institute of Oncology, Milan, Italy
| | - Anna Napoli
- Department of Pathological Anatomy, University of Bari, Piazza G. Cesare, 11, Bari, 70124 Italy
| | - Gianfranco Favia
- Department of Dental Sciences and Surgery, University of Bari, Bari, Italy
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Kacar S, Kuran S, Temucin T, Odemis B, Karadeniz N, Sasmaz N. Rectal angiolipoma: A case report and review of literature. World J Gastroenterol 2007; 13:1460-5. [PMID: 17457984 PMCID: PMC4146937 DOI: 10.3748/wjg.v13.i9.1460] [Citation(s) in RCA: 18] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Indexed: 02/06/2023] Open
Abstract
Angiolipoma is a rare vascular variant of the benign lipomatous tumors and is generally seen in subcutaneous tissues. We report a 70-year-old female with abdominal distension not related to rectal small polypoid mass with peduncule described as angiolipoma by histologically, and review the literature.
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Affiliation(s)
- Sabite Kacar
- Gastroenterology Department, Türkiye Yüksek Ihtisas Hospital, Ankara, Turkey
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14
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Ida-Yonemochi H, Swelam W, Saito C, Saku T. Angiolipoma of the buccal mucosa: a possible role of mast cell-derived VEGF in its enhanced vascularity. J Oral Pathol Med 2005; 34:59-61. [PMID: 15610409 DOI: 10.1111/j.1600-0714.2004.00230.x] [Citation(s) in RCA: 16] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/28/2022]
Abstract
A case of angiolipoma occurring in the buccal mucosa of a 69-year-old male is described. The patient had noticed a painless mass in his buccal mucosa for 2 years. The surgically removed tumor, measuring 9 mm in diameter, was mainly located in the submucosal layer with focal expansion into the muscle layer. Histologically, the tumor was well-demarcated and composed of proliferations of mature fat cells and fibrous connective tissue containing many small blood vessels, which were evenly distributed. There was diffuse infiltration of a large number of mast cells, which were immunopositive for vascular endothelial growth factor (VEGF) especially around blood vessels, suggesting that VEGF produced by mast cells in angiolipomas plays an important role in the vascular proliferation in this particular tumor.
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Affiliation(s)
- Hiroko Ida-Yonemochi
- Division of Oral Pathology, Department of Tissue Regeneration and Reconstruction, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
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15
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Sandberg AA. Updates on the cytogenetics and molecular genetics of bone and soft tissue tumors: lipoma. ACTA ACUST UNITED AC 2004; 150:93-115. [PMID: 15066317 DOI: 10.1016/j.cancergencyto.2003.12.018] [Citation(s) in RCA: 58] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/30/2003] [Revised: 12/22/2003] [Accepted: 12/24/2003] [Indexed: 02/02/2023]
Affiliation(s)
- Avery A Sandberg
- Department of DNA Diagnostics, St. Joseph's Hospital and Medical Center, 350 West Thomas Road, Phoenix, AZ 85013, USA.
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Abstract
OBJECTIVE To present the first documented case of an angiolipoma of the maxillary sinus, our treatment of the patient, and the 1-year follow-up results. At the conclusion of the report, the reader should be able to discuss the incidence, treatment options, and long-term prognosis of angiolipomas of the paranasal sinuses. STUDY DESIGN A case study reporting on a single patient with the diagnosis of maxillary sinus angiolipoma. METHODS Review of diagnostic studies, the operative technique, and the patient's chart for the 1-year period after treatment. RESULTS The patient remains free of disease 1 year after definitive surgical treatment. CONCLUSIONS Angiolipomas are exceedingly rare in this location. The accepted treatment for this disease in other regions of the body consists of wide local excision with close follow-up. The extent of the disease found in this patient required a medial maxillectomy for en bloc resection. We would advocate such an approach for other physicians who are faced with a patient with this rare diagnosis.
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Affiliation(s)
- Travis J Pfannenstiel
- Department of Otolaryngology, Brooke Army Medical Center, Fort Sam Houston, Texas 78234-6200, USA
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Jones AC, Trochesset D, Freedman PD. Intraoral benign mesenchymoma: a report of 10 cases and review of the literature. ORAL SURGERY, ORAL MEDICINE, ORAL PATHOLOGY, ORAL RADIOLOGY, AND ENDODONTICS 2003; 95:67-76. [PMID: 12539029 DOI: 10.1067/moe.2003.52] [Citation(s) in RCA: 28] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 11/22/2022]
Abstract
A benign mesenchymoma is an unencapsulated soft tissue neoplasm composed of 2 or more mature mesenchymal tissues not normally associated with each other, excluding fibrous connective tissue. No single mesenchymal tissue should predominate with respect to the other mesenchymal elements. Ten well-documented examples of intraoral benign mesenchymoma have been reported in the English language literature. The purpose of this report is to document 10 additional cases and to review the clinicopathologic characteristics of this uncommon tumor.
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Affiliation(s)
- Anne Cale Jones
- The University of Texas Health Science Center, Graduate School of Biomedical Sciences, San Antonio, Tex 78229-3900, USA.
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