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For: Qin S, Huang Z, Wang Y, Pei L, Shen Y. Probiotic potential of Lactobacillus isolated from horses and its therapeutic effect on DSS-induced colitis in mice. Microb Pathog 2021;165:105216. [PMID: 34600098 DOI: 10.1016/j.micpath.2021.105216] [Citation(s) in RCA: 15] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/30/2021] [Revised: 09/24/2021] [Accepted: 09/26/2021] [Indexed: 01/17/2023]

For:	Qin S, Huang Z, Wang Y, Pei L, Shen Y. Probiotic potential of Lactobacillus isolated from horses and its therapeutic effect on DSS-induced colitis in mice. Microb Pathog 2021;165:105216. [PMID: 34600098 DOI: 10.1016/j.micpath.2021.105216] [Citation(s) in RCA: 15] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/30/2021] [Revised: 09/24/2021] [Accepted: 09/26/2021] [Indexed: 01/17/2023]

Number

Cited by Other Article(s)

Zhu D, Wang B, Xu Z, Yan Z, Kulyar MF, Li S, Chen Y, Khateeb E, He S, Shen Y. Vitamin B₁₂-producing Cetobacterium: An important biomarker linked to snake hibernation. Int J Biol Macromol 2025;306:141827. [PMID: 40057061 DOI: 10.1016/j.ijbiomac.2025.141827] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/29/2024] [Revised: 03/04/2025] [Accepted: 03/05/2025] [Indexed: 05/01/2025]

Tang H, Fan Q, Lu Y, Lin X, Lan R, Hu D, Zhang S, Wang R, Zhao R, Liu L, Xu J. Weissella confusa alleviates experimental colitis in mice by regulating inflammatory pathways and gut microbiota. Front Microbiol 2025;16:1574548. [PMID: 40356657 PMCID: PMC12068860 DOI: 10.3389/fmicb.2025.1574548] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/11/2025] [Accepted: 04/03/2025] [Indexed: 05/15/2025] Open

Abstract

Background

Inflammatory bowel disease (IBD) is a chronic condition with no cure. Probiotics may offer a new strategy for the treatment of IBD. Weissella confusa has been shown to have antibacterial, anti-inflammatory, and antioxidant beneficial effects in animal models. However, the anti-inflammatory effect of W. confusa at host cellular level and their effect on the gut microbiota are unclear. This study aimed to investigate the effects of W. confusa Wc1982 on inflammation and gut microbiota alterations in a dextran sulfate sodium (DSS) induced colitis mouse model.

Method

Female C57BL/6J mice were randomly divided into control, DSS, and Wc1982 groups (n = 6/group). The Wc1982 group was given continuous gavage of W. confusa Wc1982 for 14 days with the last 7 days also treated with 3% DSS. Disease phenotypes including daily body weight, disease activity index (DAI), colon length and histological changes were evaluated. The composition of colon flora, α-diversity and β-diversity were analyzed by 16S rRNA sequencing. The colonic gene expression profile was analyzed by RNA-seq, and serum and colonic proinflammatory cytokines were assessed by enzyme-linked immunosorbent assay. Analysis of variance (ANOVA) was used to analyze the differences among groups, and Spearman rank test was used to calculate the correlation between species relative abundance and pro-inflammatory markers.

Results

Compared with DSS group, W. confusa Wc1982 significantly improved the disease phenotypes of colitis mice including decreased DAI and pathological score and reduced colon shortening, decreased colonic IL-17, IL-6, and TNF-α levels and serum lipopolysaccharide (p < 0.05), and downregulated the expression of key genes of IL-17 pathway (Lcn2, Mmp3, Mmp13, Ptgs2; p < 0.05). W. confusa Wc1982 modified the gut microbiota community of colitis mice, with increased α-diversity, increased abundance of W. confusa and Akkermansia muciniphila, and decreased abundance of Enterococcus faecalis and Escherichia coli (all p < 0.05).

Conclusion

Supplementation with W. confusa Wc1982 offers a promising strategy for alleviating colitis.

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Affiliation(s)

Huijing Tang Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Qianhua Fan Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Yao Lu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Xiaoying Lin Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Ruiting Lan School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
Dalong Hu School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia
Shuwei Zhang Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Ruoshi Wang Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Ruiqing Zhao Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China
Liyun Liu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China Research Units of Discovery of Unknown Bacteria and Function, Chinese Academy of Medical Sciences, Beijing, China Hebei Key Laboratory of Intractable Pathogens, Shijiazhuang Center for Disease Control and Prevention, Shijiazhuang, China
Jianguo Xu Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases, National Institute for Communicable Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing, China Research Units of Discovery of Unknown Bacteria and Function, Chinese Academy of Medical Sciences, Beijing, China

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Cao J, Zhang J, Wu H, Lin Y, Fang X, Yun S, Du M, Su S, Liu Y, Wang N, Bao T, Bai D, Zhao Y. Probiotic Potential of Pediococcus pentosaceus M6 Isolated from Equines and Its Alleviating Effect on DSS-Induced Colitis in Mice. Microorganisms 2025;13:957. [PMID: 40431130 PMCID: PMC12114451 DOI: 10.3390/microorganisms13050957] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/05/2025] [Revised: 04/02/2025] [Accepted: 04/17/2025] [Indexed: 05/29/2025] Open

Abstract

Colitis in equines has high morbidity and mortality rates, which severely affects the development of the equine-breeding industry. With the issuance of antibiotic bans, there is an urgent need for healthier and more effective alternatives. In recent years, probiotics have been widely used as microbial feed additives in animal husbandry, playing a crucial role in preventing and treating diarrhea and regulating host immune function. In this study, we isolated and screened a strain with rapid and stable acid production using bromocresol purple, litmus milk coloration tests, and acid production performance assessments. Based on morphological characteristics, physiological and biochemical properties, and 16S rDNA identification, the strain was identified as Pediococcus pentosaceus and named M6. The Pediococcus pentosaceus M6 exhibited stable growth and tolerance to high temperatures, acid and bile salt concentrations, and simulated gastrointestinal fluid environments. The M6 strain demonstrated good antibacterial effects against Escherichia coli, Staphylococcus aureus, and Salmonella. The M6 strain did not produce hemolysis zones on Columbia blood agar plates, indicating its high safety, and was found to be insensitive to 12 antibiotics, including cephalexin and neomycin. Additionally, intervention in mice with dextran sulfate sodium (DSS)-induced colitis alleviated weight loss and shortened colon length. To a certain extent, it regulated the expression of inflammatory cytokines and the gut microbiota within the body and reduced inflammatory cell infiltration and intestinal barrier damage. In summary, the isolated Pediococcus pentosaceus M6 strain exhibited excellent probiotic properties and could alleviate DSS-induced colitis in mice, suggesting its potential application value as a probiotic in animal husbandry.

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Affiliation(s)

Jialong Cao Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China; (J.C.); (J.Z.); (H.W.); (Y.L.); (X.F.); (S.Y.); (M.D.); (Y.L.); (N.W.); (T.B.); (D.B.) Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
Jianqiang Zhang Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China; (J.C.); (J.Z.); (H.W.); (Y.L.); (X.F.); (S.Y.); (M.D.); (Y.L.); (N.W.); (T.B.); (D.B.) Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
Hui Wu Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China; (J.C.); (J.Z.); (H.W.); (Y.L.); (X.F.); (S.Y.); (M.D.); (Y.L.); (N.W.); (T.B.); (D.B.) Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
Yanan Lin Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China; (J.C.); (J.Z.); (H.W.); (Y.L.); (X.F.); (S.Y.); (M.D.); (Y.L.); (N.W.); (T.B.); (D.B.) Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
Xinlan Fang Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China; (J.C.); (J.Z.); (H.W.); (Y.L.); (X.F.); (S.Y.); (M.D.); (Y.L.); (N.W.); (T.B.); (D.B.) Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
Siqin Yun Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China; (J.C.); (J.Z.); (H.W.); (Y.L.); (X.F.); (S.Y.); (M.D.); (Y.L.); (N.W.); (T.B.); (D.B.) Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
Ming Du Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China; (J.C.); (J.Z.); (H.W.); (Y.L.); (X.F.); (S.Y.); (M.D.); (Y.L.); (N.W.); (T.B.); (D.B.) Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
Shaofeng Su Inner Mongolia Academy of Agricultural & Animal Husbandry Sciences, Hohhot 010031, China;
Yuanyi Liu Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China; (J.C.); (J.Z.); (H.W.); (Y.L.); (X.F.); (S.Y.); (M.D.); (Y.L.); (N.W.); (T.B.); (D.B.) Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
Na Wang Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China; (J.C.); (J.Z.); (H.W.); (Y.L.); (X.F.); (S.Y.); (M.D.); (Y.L.); (N.W.); (T.B.); (D.B.) Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
Tugeqin Bao Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China; (J.C.); (J.Z.); (H.W.); (Y.L.); (X.F.); (S.Y.); (M.D.); (Y.L.); (N.W.); (T.B.); (D.B.) Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
Dongyi Bai Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China; (J.C.); (J.Z.); (H.W.); (Y.L.); (X.F.); (S.Y.); (M.D.); (Y.L.); (N.W.); (T.B.); (D.B.) Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China
Yiping Zhao Key Laboratory of Equus Germplasm Innovation, Ministry of Agriculture and Rural Affairs, Hohhot 010018, China; (J.C.); (J.Z.); (H.W.); (Y.L.); (X.F.); (S.Y.); (M.D.); (Y.L.); (N.W.); (T.B.); (D.B.) Inner Mongolia Key Laboratory of Equine Science Research and Technology Innovation, Inner Mongolia Agricultural University, Hohhot 010018, China Equus Research Center, Inner Mongolia Agricultural University, Hohhot 010018, China College of Animal Science, Inner Mongolia Agricultural University, Hohhot 010018, China

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Huang F, Yang N, Zhang Q, Luo C, Wang J, Yang Y, Yue B, Chen P, Zhang X. Marine-Derived Enterococcus faecalis HY0110 as a Next-Generation Functional Food Probiotic: Comprehensive In Vitro and In Vivo Bioactivity Evaluation and Synergistic Fermentation of Periplaneta americana Extract Powder. Foods 2025;14:1181. [PMID: 40238337 PMCID: PMC11988638 DOI: 10.3390/foods14071181] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/11/2025] [Revised: 03/23/2025] [Accepted: 03/26/2025] [Indexed: 04/18/2025] Open

Affiliation(s)

Feiyun Huang Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu 610065, China; (F.H.); (Q.Z.); (C.L.); (J.W.); (Y.Y.); (B.Y.)
Nan Yang Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Sichuan Province and Ministry of Education, Southwest Minzu University, Chengdu 610041, China;
Qingqing Zhang Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu 610065, China; (F.H.); (Q.Z.); (C.L.); (J.W.); (Y.Y.); (B.Y.)
Cuiling Luo Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu 610065, China; (F.H.); (Q.Z.); (C.L.); (J.W.); (Y.Y.); (B.Y.)
Jingheng Wang Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu 610065, China; (F.H.); (Q.Z.); (C.L.); (J.W.); (Y.Y.); (B.Y.)
Yu Yang Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu 610065, China; (F.H.); (Q.Z.); (C.L.); (J.W.); (Y.Y.); (B.Y.)
Bisong Yue Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu 610065, China; (F.H.); (Q.Z.); (C.L.); (J.W.); (Y.Y.); (B.Y.)
Peng Chen MOE Key Laboratory of Deep Earth Science and Engineering, College of Architecture and Environment, Sichuan University, Chengdu 610065, China
Xiuyue Zhang Key Laboratory of Bio-Resources and Eco-Environment (Ministry of Education), College of Life Sciences, Sichuan University, Chengdu 610065, China; (F.H.); (Q.Z.); (C.L.); (J.W.); (Y.Y.); (B.Y.) Sichuan Key Laboratory of Conservation Biology on Endangered Wildlife, College of Life Sciences, Sichuan University, Chengdu 610065, China

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Zeng Z, Gong S, Quan C, Zhou S, Kulyar MFEA, Iqbal M, Li Y, Li X, Li J. Impact of Bacillus licheniformis from yaks following antibiotic therapy in mouse model. Appl Microbiol Biotechnol 2024;108:139. [PMID: 38229401 DOI: 10.1007/s00253-023-12866-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/27/2023] [Revised: 10/19/2023] [Accepted: 10/30/2023] [Indexed: 01/18/2024]

Abstract

Gut microorganism (GM) is an integral component of the host microbiome and health system. Abuse of antibiotics disrupts the equilibrium of the microbiome, affecting environmental pathogens and host-associated bacteria alike. However, relatively little research on Bacillus licheniformis alleviates the adverse effects of antibiotics. To test the effect of B. licheniformis as a probiotic supplement against the effects of antibiotics, cefalexin was applied, and the recovery from cefalexin-induced jejunal community disorder and intestinal barrier damage was investigated by pathology, real-time PCR (RT-PCR), and high-throughput sequencing (HTS). The result showed that A group (antibiotic treatment) significantly reduced body weight and decreased the length of jejunal intestinal villi and the villi to crypt (V/C) value, which also caused structural damage to the jejunal mucosa. Meanwhile, antibiotic treatment suppressed the mRNA expression of tight junction proteins ZO-1, claudin, occludin, and Ki67 and elevated MUC2 expression more than the other Groups (P < 0.05 and P < 0.01). However, T group (B. licheniformis supplements after antibiotic treatment) restored the expression of the above genes, and there was no statistically significant difference compared to the control group (P > 0.05). Moreover, the antibiotic treatment increased the relative abundance of 4 bacterial phyla affiliated with 16 bacterial genera in the jejunum community, including the dominant Firmicutes, Proteobacteria, and Cyanobacteria in the jejunum. B. licheniformis supplements after antibiotic treatment reduced the relative abundance of Bacteroidetes and Proteobacteria and increased the relative abundance of Firmicutes, Epsilonbacteraeota, Lactobacillus, and Candidatus Stoquefichus. This study uses mimic real-world exposure scenarios by considering the concentration and duration of exposure relevant to environmental antibiotic contamination levels. We described the post-antibiotic treatment with B. licheniformis could restore intestinal microbiome disorders and repair the intestinal barrier. KEY POINTS: • B. licheniformis post-antibiotics restore gut balance, repair barrier, and aid health • Antibiotics harm the gut barrier, alter structure, and raise disease risk • Long-term antibiotics affect the gut and increase disease susceptibility.

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Fernandes FG, da Costa WKA, Dos Santos Lima M, de Lima Costa IH, Magnani M, da Silva Campelo Borges G. A new plant-based probiotic from juá: Source of phenolics, fibers and antioxidant properties. Food Chem 2024;458:140162. [PMID: 38943964 DOI: 10.1016/j.foodchem.2024.140162] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/21/2023] [Revised: 05/29/2024] [Accepted: 06/17/2024] [Indexed: 07/01/2024]

Mikshina P, Kharina M, Sungatullina A, Petrova T, Sibgatullin T, Nikitina E. Influence of flaxseed mucilage on the formation, composition, and properties of exopolysaccharides produced by different strains of lactic acid bacteria. Int J Biol Macromol 2024;281:136092. [PMID: 39349088 DOI: 10.1016/j.ijbiomac.2024.136092] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/12/2024] [Revised: 09/11/2024] [Accepted: 09/25/2024] [Indexed: 10/02/2024]

Xu M, Hu M, Han J, Wang L, He Y, Kulyar MF, Zhang X, Lu Y, Mu S, Su H, Cao J, Li J. The Therapeutic Effects of Lactic Acid Bacteria Isolated from Spotted Hyena on Dextran Sulfate Sodium-Induced Ulcerative Colitis in Mice. Nutrients 2024;16:3682. [PMID: 39519515 PMCID: PMC11547871 DOI: 10.3390/nu16213682] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/14/2024] [Revised: 09/28/2024] [Accepted: 10/08/2024] [Indexed: 11/16/2024] Open

Wang M, Ma Y, Yu G, Zeng B, Yang W, Huang C, Dong Y, Tang B, Wu Z. Integration of microbiome, metabolomics and transcriptome for in-depth understanding of berberine attenuates AOM/DSS-induced colitis-associated colorectal cancer. Biomed Pharmacother 2024;179:117292. [PMID: 39151314 DOI: 10.1016/j.biopha.2024.117292] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/12/2024] [Revised: 08/06/2024] [Accepted: 08/09/2024] [Indexed: 08/19/2024] Open

Muro P, Zhang L, Li S, Zhao Z, Jin T, Mao F, Mao Z. The emerging role of oxidative stress in inflammatory bowel disease. Front Endocrinol (Lausanne) 2024;15:1390351. [PMID: 39076514 PMCID: PMC11284038 DOI: 10.3389/fendo.2024.1390351] [Citation(s) in RCA: 33] [Impact Index Per Article: 33.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 02/23/2024] [Accepted: 06/19/2024] [Indexed: 07/31/2024] Open

Zhao N, Huang X, Liu Z, Gao Y, Teng J, Yu T, Yan F. Probiotic characterization of Bacillus smithii: Research advances, concerns, and prospective trends. Compr Rev Food Sci Food Saf 2024;23:e13308. [PMID: 38369927 DOI: 10.1111/1541-4337.13308] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/02/2023] [Revised: 01/16/2024] [Accepted: 01/22/2024] [Indexed: 02/20/2024]

Zeng Z, Huang Z, Yue W, Nawaz S, Chen X, Liu J. Lactobacillus plantarum modulate gut microbiota and intestinal immunity in cyclophosphamide-treated mice model. Biomed Pharmacother 2023;169:115812. [PMID: 37979376 DOI: 10.1016/j.biopha.2023.115812] [Citation(s) in RCA: 13] [Impact Index Per Article: 6.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/09/2023] [Revised: 10/22/2023] [Accepted: 10/26/2023] [Indexed: 11/20/2023] Open

Jin W, Ai H, Huang Q, Li C, He X, Jin Z, Zuo Y. Preclinical evidence of probiotics in ulcerative colitis: a systematic review and network meta-analysis. Front Pharmacol 2023;14:1187911. [PMID: 37361217 PMCID: PMC10288114 DOI: 10.3389/fphar.2023.1187911] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/16/2023] [Accepted: 05/30/2023] [Indexed: 06/28/2023] Open

He Y, Xu M, Lu S, Zou W, Wang Y, Fakhar-E-Alam Kulyar M, Iqbal M, Li K. Seaweed polysaccharides treatment alleviates injury of inflammatory responses and gut barrier in LPS-induced mice. Microb Pathog 2023;180:106159. [PMID: 37201636 DOI: 10.1016/j.micpath.2023.106159] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/13/2023] [Revised: 05/14/2023] [Accepted: 05/15/2023] [Indexed: 05/20/2023]

Roy S, Dhaneshwar S. Role of prebiotics, probiotics, and synbiotics in management of inflammatory bowel disease: Current perspectives. World J Gastroenterol 2023;29:2078-2100. [PMID: 37122604 PMCID: PMC10130969 DOI: 10.3748/wjg.v29.i14.2078] [Citation(s) in RCA: 107] [Impact Index Per Article: 53.5] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 10/28/2022] [Revised: 11/29/2022] [Accepted: 03/21/2023] [Indexed: 04/13/2023] Open

Abstract

Experimental evidence supports the fact that changes in the bowel microflora due to environmental or dietary factors have been investigated as implicating factors in the etiopathogenesis of inflammatory bowel disease (IBD). The amassing knowledge that the inhabited microbiome regulates the gut physiology and immune functions in IBD, has led researchers to explore the effectiveness of prebiotics, probiotics, and synbiotics in treating IBD. This therapeutic approach focuses on restoring the dynamic balance between the microflora and host defense mechanisms in the intestinal mucosa to prevent the onset and persistence of intestinal inflammation. Numerous microbial strains and carbohydrate blends, along with their combinations have been examined in experimental colitis models and clinical trials, and the results indicated that it can be an attractive therapeutic strategy for the suppression of inflammation, remission induction, and relapse prevention in IBD with minimal side effects. Several mechanisms of action of probiotics (for e.g., Lactobacillus species, and Bifidobacterium species) have been reported such as suppression of pathogen growth by releasing certain antimicrobial mediators (lactic and hydrogen peroxide, acetic acid, and bacteriocins), immunomodulation and initiation of an immune response, enhancement of barrier activity, and suppression of human T-cell proliferation. Prebiotics such as lactulose, lactosucrose, oligofructose, and inulin have been found to induce the growth of certain types of host microflora, resulting in an enriched enteric function. These non-digestible food dietary components have been reported to exert anti-inflammatory effects by inhibiting the expression of tumor necrosis factor-α-related cytokines while augmenting interleukin-10 levels. Although pro-and prebiotics has established their efficacy in healthy subjects, a better understanding of the luminal ecosystem is required to determine which specific bacterial strain or combination of probiotics and prebiotics would prove to be the ideal treatment for IBD. Clinical trials, however, have given some conflicting results, requiring the necessity to cite the more profound clinical effect of these treatments on IBD remission and prevention. The purpose of this review article is to provide the most comprehensive and updated review on the utility of prebiotics, probiotics, and synbiotics in the management of active Crohn's disease and ulcerative colitis/pouchitis.

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The Profile of Exopolysaccharides Produced by Various Lactobacillus Species from Silage during Not-Fat Milk Fermentation. FERMENTATION-BASEL 2023. [DOI: 10.3390/fermentation9020197] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 02/25/2023]

Ma X, Li J, Yang L, Liu H, Zhu Y, Ren H, Yu F, Liu B. Short Term Effect of Ivermectin on the Bacterial Microbiota from Fecal Samples in Chinchillas (Chinchilla lanigera). Vet Sci 2023;10:vetsci10020169. [PMID: 36851473 PMCID: PMC9960913 DOI: 10.3390/vetsci10020169] [Citation(s) in RCA: 2] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/09/2023] [Revised: 02/10/2023] [Accepted: 02/12/2023] [Indexed: 02/22/2023] Open

Wang W, Li X, Shi F, Zhang Z, Lv H. Study on the preparation of EGCG-γ-Cyclodextrin inclusion complex and its drug-excipient combined therapeutic effects on the treatment of DSS-induced acute ulcerative colitis in mice. Int J Pharm 2022;630:122419. [PMID: 36423710 DOI: 10.1016/j.ijpharm.2022.122419] [Citation(s) in RCA: 10] [Impact Index Per Article: 3.3] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/09/2022] [Revised: 11/01/2022] [Accepted: 11/16/2022] [Indexed: 11/23/2022]

Zhang Y, Feng D, Zeng Y, Zhang H, Du X, Fu Y, Wang X, Lian D, Wang R, Xiao H, Wei N, Zhai F, Liu H. Xuedan Sustained Release Pellets Ameliorate Dextran Sulfate Sodium-Induced Ulcerative Colitis in Rats by Targeting Gut Microbiota and MAPK Signaling Pathways. Front Pharmacol 2022;13:833972. [PMID: 35652042 PMCID: PMC9149600 DOI: 10.3389/fphar.2022.833972] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/12/2021] [Accepted: 03/09/2022] [Indexed: 12/12/2022] Open

Abstract

Cucurbitacins have a variety of bioactivities, such as anticancer, anti-inflammatory, antidepressant-like, and antiviral effects, but their pharmacological effect in ulcerative colitis (UC) has not been reported until now. Thus, this study aims to investigate the preventive effects of Xuedan sustained release pellets (XSPs) on UC rats and the underlying mechanisms. XSPs were prepared by extracting cucurbitacins from Hemsleya. Experimental UC rats were induced by the intake of 4% dextran sulfate sodium (DSS) for a week and treated with different doses of XSP (0.95, 1.90, and 3.8 mg/kg). The body weight, colon length, disease activity index (DAI), and histological changes of colonic tissue were measured. In addition, the expressions of pro-inflammatory cytokines were detected by using the enzyme-linked immunosorbent assay. Pathways involved in the intestinal inflammation were targeted by RNA-sequencing. Moreover, the changes of gut microbial diversity and composition were analyzed by the 16SrNA analysis and the contents of short-chain fatty acids (SCFAs) were detected by GC-MS. The results revealed that XSP intervention greatly restored the weight loss and colonic shortening (p < 0.05) and reduced the raised DAI scores, myeloperoxidase, and nitric oxide activities in UC in rats (p < 0.05). XSP administration also downregulated the protein levels of pro-inflammatory factors IL-1β, IL-6, and TNF-α. Notably, it was found that XSP considerably suppressed the activation of the MAPK signaling pathway. In addition, XSP treatment improved the balance of gut microbiota that was disturbed by DSS. The beneficial bacteria Lachnospiraceae_NK4A136 group and Lactobacillus at the genus level significantly increased in the XSP group, which had decreased with the use of DSS (p < 0.05). Pathogenic bacteria including Escherichia-Shigella and Bacteroides in UC in rats were reduced by XSP intervention. Furthermore, XSP significantly elevated the production of SCFAs in UC in rats (p < 0.05). These alterations in inflammatory status were accompanied with changes in gut microbiota diversity and SCFA production. In conclusion, XSP exhibited protective effects against DSS-induced UC in rats. XSP treatment decreased inflammation via modulation of gut microbiota composition and SCFA production.

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Wang N, Li J, Wang Y, Wang Y, Zhang D, Shi C, Li Y, Bergmann SM, Mo X, Yin J, Wang Q. Recombinant Lactococcus lactis Expressing Grass Carp Reovirus VP6 Induces Mucosal Immunity Against Grass Carp Reovirus Infection. Front Immunol 2022;13:914010. [PMID: 35634331 PMCID: PMC9132009 DOI: 10.3389/fimmu.2022.914010] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/06/2022] [Accepted: 04/19/2022] [Indexed: 11/13/2022] Open

Affiliation(s)

Nan Wang Key Laboratory of Fishery Drug Development of Ministry of Agriculture, Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China
Jiahao Li Key Laboratory of Fishery Drug Development of Ministry of Agriculture, Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China
Yajun Wang Key Laboratory of Fishery Drug Development of Ministry of Agriculture, Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China
Yingying Wang Key Laboratory of Fishery Drug Development of Ministry of Agriculture, Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China
Defeng Zhang Key Laboratory of Fishery Drug Development of Ministry of Agriculture, Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China
Cunbin Shi Key Laboratory of Fishery Drug Development of Ministry of Agriculture, Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China
Yingying Li Key Laboratory of Fishery Drug Development of Ministry of Agriculture, Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China
Sven M Bergmann Institute of Infectology, Friedrich-Loffler-Institut (FLI), Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany
Xubing Mo Key Laboratory of Fishery Drug Development of Ministry of Agriculture, Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China
Jiyuan Yin Key Laboratory of Fishery Drug Development of Ministry of Agriculture, Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China
Qing Wang Key Laboratory of Fishery Drug Development of Ministry of Agriculture, Key Laboratory of Aquatic Animal Immune Technology of Guangdong Province, Pearl River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Guangzhou, China

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Saccharomyces cerevisiae I4 Showed Alleviating Effects on Dextran Sulfate Sodium-Induced Colitis of Balb/c Mice. Foods 2022;11:foods11101436. [PMID: 35627006 PMCID: PMC9140780 DOI: 10.3390/foods11101436] [Citation(s) in RCA: 5] [Impact Index Per Article: 1.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/12/2022] [Revised: 05/06/2022] [Accepted: 05/10/2022] [Indexed: 02/01/2023] Open

Zeng Z, Zhang J, Li Y, Li K, Gong S, Li F, Wang P, Iqbal M, Kulyar MFEA, Li J. Probiotic Potential of Bacillus licheniformis and Bacillus pumilus Isolated from Tibetan Yaks, China. Probiotics Antimicrob Proteins 2022;14:579-594. [PMID: 35445290 DOI: 10.1007/s12602-022-09939-z] [Citation(s) in RCA: 14] [Impact Index Per Article: 4.7] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 04/06/2022] [Indexed: 01/02/2023]