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For: Battaglioni S, Benjamin D, Wälchli M, Maier T, Hall MN. mTOR substrate phosphorylation in growth control. Cell 2022;185:1814-36. [PMID: 35580586 DOI: 10.1016/j.cell.2022.04.013] [Citation(s) in RCA: 230] [Impact Index Per Article: 76.7] [Reference Citation Analysis] [What about the content of this article? (0)] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/08/2022] [Revised: 04/05/2022] [Accepted: 04/07/2022] [Indexed: 12/20/2022]
Number Cited by Other Article(s)
1
Zhang Z, Shen Z, Xie S, Li J, Zhang Z, Zhang S, Peng B, Huang Q, Li M, Ma S, Huang Q. Rapamycin exerts neuroprotective effects by inhibiting FKBP12 instead of mTORC1 in the mouse model of Parkinson's disease. Neuropharmacology 2025;275:110504. [PMID: 40345576 DOI: 10.1016/j.neuropharm.2025.110504] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/24/2024] [Revised: 04/28/2025] [Accepted: 05/05/2025] [Indexed: 05/11/2025]
2
Kawahara T, Inazu T, Mizuno S, Tominaga N, Toda M, Toyama N, Kawahara C, Suzuki G. Anti-sarcopenic effects of active vitamin D through modulation of anabolic and catabolic signaling pathways in human skeletal muscle: A randomized controlled trial. Metabolism 2025;168:156240. [PMID: 40158795 DOI: 10.1016/j.metabol.2025.156240] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 11/22/2024] [Revised: 03/14/2025] [Accepted: 03/22/2025] [Indexed: 04/02/2025]
3
O'Leary KM, Slezak T, Kossiakoff AA. Conformation-specific synthetic intrabodies modulate mTOR signaling with subcellular spatial resolution. Proc Natl Acad Sci U S A 2025;122:e2424679122. [PMID: 40489625 DOI: 10.1073/pnas.2424679122] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/25/2024] [Accepted: 04/02/2025] [Indexed: 06/11/2025]  Open
4
Kwakye J, Ariyo OW, Ghareeb AFA, Hartono E, Aryal B, Sovi S, Milfort MC, Fuller AL, Rekaya R, Aggrey SE. Effect of glucose supplementation on protein biosynthesis in chickens reared under thermoneutral or heat stress environment. Gene 2025;951:149408. [PMID: 40064307 DOI: 10.1016/j.gene.2025.149408] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/01/2024] [Revised: 01/13/2025] [Accepted: 03/06/2025] [Indexed: 03/14/2025]
5
Evans JF, Ledwell OA, Tang Y, Rue R, Mukhitov AR, Diesler R, Lin SM, Vanka KS, Basil MC, Cantu E, Henske EP, Krymskaya VP. The Bi-steric Inhibitor RMC-5552 Reduces mTORC1 Signaling and Growth in Lymphangioleiomyomatosis. Am J Respir Cell Mol Biol 2025;72:643-652. [PMID: 39531634 DOI: 10.1165/rcmb.2024-0242oc] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/24/2024] [Accepted: 11/12/2024] [Indexed: 11/16/2024]  Open
6
Gao R, Shi J, Lyu Y, Ren B, Wei W, Cheng J, Chen J, Zhou Y, Chen J, Sun X, Jiang J, Li B, Yang K. ALKBH5 Regulates Macrophage Senescence and Accelerates Atherosclerosis by Promoting CCL5 m6A Modification. Arterioscler Thromb Vasc Biol 2025;45:928-944. [PMID: 40177773 DOI: 10.1161/atvbaha.125.322508] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/25/2025] [Accepted: 03/20/2025] [Indexed: 04/05/2025]
7
Rao G, Sang X, Zhu X, Zou S, Zhang Y, Cheng W, Tian Y, Fu X. Pathological Glucose Levels Enhance Entry Factor Expression and Hepatic SARS-CoV-2 Infection. J Cell Mol Med 2025;29:e70581. [PMID: 40442985 PMCID: PMC12122388 DOI: 10.1111/jcmm.70581] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/16/2024] [Revised: 04/17/2025] [Accepted: 04/23/2025] [Indexed: 06/02/2025]  Open
8
He D, Dai W, Cui Y, Gao R, Yang X, Li W, Zhou J, Yin S, Kuang T, Zhu J, Luo L, Wang R, Qu Y, Yun C, Liu Z, Diao X, Ma X, Liang H, Wang F. Diamine oxidase acts as a novel risk factor in abnormal inflammation via mediating "cytosolic ROS-autophagy-IFN-γ" axis in NK cells. Life Sci 2025;377:123775. [PMID: 40449879 DOI: 10.1016/j.lfs.2025.123775] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/12/2025] [Revised: 05/21/2025] [Accepted: 05/27/2025] [Indexed: 06/03/2025]
9
Mantoan Ritter L, Annear NMP, Baple EL, Ben-Chaabane LY, Bodi I, Brosson L, Cadwgan JE, Coslett B, Crosby AH, Davies DM, Daykin N, Dedeurwaerdere S, Dühring Fenger C, Dunlop EA, Elmslie FV, Girodengo M, Hambleton S, Jansen AC, Johnson SR, Kearley KC, Kingswood JC, Laaniste L, Lachlan K, Latchford A, Madsen RR, Mansour S, Mihaylov SR, Muhammed L, Oliver C, Pepper T, Rawlins LE, Schim van der Loeff I, Siddiqui A, Takhar P, Tatton-Brown K, Tee AR, Tibarewal P, Tye C, Ultanir SK, Vanhaesebroeck B, Zare B, Pal DK, Bateman JM. mTOR pathway diseases: challenges and opportunities from bench to bedside and the mTOR node. Orphanet J Rare Dis 2025;20:256. [PMID: 40426219 PMCID: PMC12107773 DOI: 10.1186/s13023-025-03740-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/06/2024] [Accepted: 04/16/2025] [Indexed: 05/29/2025]  Open
10
Kraft M, Schoofs H, Petkova M, Andrade J, Grosso AR, Benedito R, De Roo AK, Boon LM, Vikkula M, Kapp FG, Hägerling R, Potente M, Mäkinen T. Angiopoietin-TIE2 feedforward circuit promotes PIK3CA-driven venous malformations. NATURE CARDIOVASCULAR RESEARCH 2025:10.1038/s44161-025-00655-9. [PMID: 40410415 DOI: 10.1038/s44161-025-00655-9] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 11/06/2023] [Accepted: 04/11/2025] [Indexed: 05/25/2025]
11
Zhang F, Xu J, Yuan Q, Xie Y, Zhang L, Zhang J, Xu Z, Liu M. Deletion of ZNRF2 Exacerbates MPTP-Induced Parkinson's Disease by Activating mTOR-Mediated Neuroinflammatory Pathways. Mol Neurobiol 2025:10.1007/s12035-025-05044-8. [PMID: 40402410 DOI: 10.1007/s12035-025-05044-8] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/21/2024] [Accepted: 05/06/2025] [Indexed: 05/23/2025]
12
Ren S, Zhu J, Shan G, Liang J, Bian Y, Lin H, Shi H, Pan B, Zhao G, Yang H, Huang X, Zhan C, Ge D, Bi G. Transcription factor ZNF266 suppresses cancer progression by modulating CA9-mediated intracellular pH alteration in lung adenocarcinoma. Respir Res 2025;26:191. [PMID: 40389968 PMCID: PMC12090625 DOI: 10.1186/s12931-025-03278-7] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/11/2025] [Accepted: 05/15/2025] [Indexed: 05/21/2025]  Open
13
Hou T, Yan P, Inuzuka H, Wei W. Lysosomal EGFR functions as a GEF for Rheb. Cell Res 2025:10.1038/s41422-025-01126-3. [PMID: 40335660 DOI: 10.1038/s41422-025-01126-3] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 05/09/2025]  Open
14
Han F, Simeroth S, Zhu J, Gryniuk I, Pranay A, Chen W, Wang Y, Cai Y, Shen Z, Wang G, Griffin CT, Xia L, Yu P. Lymphatic endothelial mTORC1 instructs metabolic and developmental signaling during lymphangiogenesis. Dev Cell 2025:S1534-5807(25)00250-3. [PMID: 40339577 DOI: 10.1016/j.devcel.2025.04.012] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/07/2023] [Revised: 11/10/2024] [Accepted: 04/16/2025] [Indexed: 05/10/2025]
15
Niu P, Li D, Chen H, Zhu Y, Zhou J, Zhang J, Liu Y. Cardamonin suppresses mTORC1/SREBP1 through reducing Raptor and inhibits de novo lipogenesis in ovarian cancer. PLoS One 2025;20:e0322733. [PMID: 40315213 PMCID: PMC12047825 DOI: 10.1371/journal.pone.0322733] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/07/2024] [Accepted: 03/25/2025] [Indexed: 05/04/2025]  Open
16
McKenzie CI, Dvorscek AR, Ding Z, Robinson MJ, O'Donnell K, Pitt C, Ferguson DT, Mulder J, Herold MJ, Tarlinton DM, Quast I. Syndecans and glycosaminoglycans influence B-cell development and activation. EMBO Rep 2025;26:2435-2458. [PMID: 40155751 PMCID: PMC12069707 DOI: 10.1038/s44319-025-00432-6] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/19/2024] [Revised: 03/07/2025] [Accepted: 03/12/2025] [Indexed: 04/01/2025]  Open
17
Hartung J, Müller C, Calkhoven CF. The dual role of the TSC complex in cancer. Trends Mol Med 2025;31:452-465. [PMID: 39488444 DOI: 10.1016/j.molmed.2024.10.009] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/19/2024] [Revised: 10/10/2024] [Accepted: 10/14/2024] [Indexed: 11/04/2024]
18
Bankolé A, Srivastava A, Shihavuddin A, Tighanimine K, Faucourt M, Koka V, Weill S, Nemazanyy I, Nelson AJ, Stokes MP, Delgehyr N, Genovesio A, Meunier A, Fumagalli S, Pende M, Spassky N. mTOR controls ependymal cell differentiation by targeting the alternative cell cycle and centrosomal proteins. EMBO Rep 2025:10.1038/s44319-025-00460-2. [PMID: 40307619 DOI: 10.1038/s44319-025-00460-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/21/2024] [Revised: 03/18/2025] [Accepted: 04/04/2025] [Indexed: 05/02/2025]  Open
19
Li Y, Lang M, He Q, Hu Y, Shi H, Zheng S, Wu Z, Zhou S. Nutritional and hormonal regulation of mitochondrial biogenesis drives fat body remodeling for reproductive competence. J Adv Res 2025:S2090-1232(25)00285-1. [PMID: 40306618 DOI: 10.1016/j.jare.2025.04.041] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/07/2025] [Revised: 04/04/2025] [Accepted: 04/26/2025] [Indexed: 05/02/2025]  Open
20
Chen X, Zhu Y, Xia L, Su S, Fan S, Lu Y, Chen Q, Wei Y, Huang Q, Liu X, Peng X. Glutamine limits NLRP3 inflammasome activation and pyroptosis in macrophages by sustaining the IRG1/itaconate axis. FEBS J 2025. [PMID: 40296302 DOI: 10.1111/febs.70119] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/02/2024] [Revised: 01/18/2025] [Accepted: 04/17/2025] [Indexed: 04/30/2025]
21
Li X, Han M, Zhu H, Pan Y, Su C, Liu Y, Liao Z, Zhang B, Chen X. m6A-Mediated TMCO3 Promotes Hepatocellular Carcinoma Progression by Facilitating the Membrane Translocation and Activation of AKT. ADVANCED SCIENCE (WEINHEIM, BADEN-WURTTEMBERG, GERMANY) 2025:e2504187. [PMID: 40285646 DOI: 10.1002/advs.202504187] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/07/2025] [Indexed: 04/29/2025]
22
Dong Z, She X, Ma J, Chen Q, Gao Y, Chen R, Qin H, Shen B, Gao H. The E3 Ligase NEDD4L Prevents Colorectal Cancer Liver Metastasis via Degradation of PRMT5 to Inhibit the AKT/mTOR Signaling Pathway. ADVANCED SCIENCE (WEINHEIM, BADEN-WURTTEMBERG, GERMANY) 2025:e2504704. [PMID: 40279519 DOI: 10.1002/advs.202504704] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 03/15/2025] [Indexed: 04/27/2025]
23
Park S, Jeong J, Ahn K. Human cytomegalovirus infection induces L1 expression through UL38-dependent mTOR-KAP1 pathway. PLoS One 2025;20:e0320512. [PMID: 40267069 PMCID: PMC12017509 DOI: 10.1371/journal.pone.0320512] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/20/2024] [Accepted: 02/19/2025] [Indexed: 04/25/2025]  Open
24
He X, Wang QX, Wei D, Lin Y, Zhang X, Wu Y, Qian X, Lin Z, Xiao B, Wu Q, Wang Z, Zhou F, Wei Z, Wang J, Gong R, Zhang R, Zhang Q, Ding K, Gao S, Kang T. Lysosomal EGFR acts as a Rheb-GEF independent of its kinase activity to activate mTORC1. Cell Res 2025:10.1038/s41422-025-01110-x. [PMID: 40259053 DOI: 10.1038/s41422-025-01110-x] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/09/2024] [Accepted: 03/19/2025] [Indexed: 04/23/2025]  Open
25
Huang H, Hu J. Applications of Liquid-Liquid Phase Separation in Biosensing. Chembiochem 2025;26:e202500028. [PMID: 39920037 DOI: 10.1002/cbic.202500028] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/13/2025] [Revised: 02/06/2025] [Accepted: 02/07/2025] [Indexed: 02/09/2025]
26
Gounis M, Hamidi H, Ivaska J. mTORC1 shutdown unleashes TFEB to drive triple-negative breast cancer invasion. Dev Cell 2025;60:979-981. [PMID: 40199239 DOI: 10.1016/j.devcel.2025.03.006] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/06/2025] [Revised: 03/07/2025] [Accepted: 03/07/2025] [Indexed: 04/10/2025]
27
Remy D, Antoine-Bally S, de Toqueville S, Jolly C, Macé AS, Champenois G, Nemati F, Brito I, Raynal V, Priya A, Berlioz A, Dahmani A, Nicolas A, Meseure D, Marangoni E, Chavrier P. TFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression. Dev Cell 2025;60:1018-1035.e8. [PMID: 39729986 DOI: 10.1016/j.devcel.2024.12.005] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/13/2023] [Revised: 08/14/2024] [Accepted: 12/02/2024] [Indexed: 12/29/2024]
28
Zhang Y, Wang T, Wang Z, Shi X, Jin J. Functions and Therapeutic Potentials of Long Noncoding RNA in Skeletal Muscle Atrophy and Dystrophy. J Cachexia Sarcopenia Muscle 2025;16:e13747. [PMID: 40034097 PMCID: PMC11876862 DOI: 10.1002/jcsm.13747] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/05/2024] [Revised: 12/23/2024] [Accepted: 02/04/2025] [Indexed: 03/05/2025]  Open
29
Ni M, Zhu Y, Chen Y, Zhao S, Gao A, Lu J, Wang W, Liu R, Gu W, Hong J, Wang J. A gain-of-function variant in RICTOR predisposes to human obesity. J Genet Genomics 2025;52:549-558. [PMID: 39984155 DOI: 10.1016/j.jgg.2025.02.002] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/25/2024] [Revised: 02/09/2025] [Accepted: 02/09/2025] [Indexed: 02/23/2025]
30
Xing Z, Zhang Y, Kang H, Dong H, Zhu D, Liu Y, Sun C, Guo P, Hu B, Tan A. ABHD5 regulates midgut-specific lipid homeostasis in Bombyx mori. INSECT SCIENCE 2025;32:425-436. [PMID: 38841829 DOI: 10.1111/1744-7917.13386] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Received: 02/04/2024] [Revised: 03/27/2024] [Accepted: 05/03/2024] [Indexed: 06/07/2024]
31
Shi XN, Liu CY, Li L, Yao ML, Zhong Z, Jiang YM. The role and therapeutic potential of mitophagy in major depressive disorder. Front Pharmacol 2025;16:1564276. [PMID: 40206060 PMCID: PMC11979158 DOI: 10.3389/fphar.2025.1564276] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/21/2025] [Accepted: 03/05/2025] [Indexed: 04/11/2025]  Open
32
Li Y, Sun S, Li G, Yang Z, Xing Y, Wang R, Xuan Y, Yang X. The TOR Signaling Pathway Governs Fungal Development, Virulence and Ustiloxin Biosynthesis in Ustilaginoidea virens. J Fungi (Basel) 2025;11:239. [PMID: 40278060 PMCID: PMC12028740 DOI: 10.3390/jof11040239] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/14/2025] [Revised: 03/11/2025] [Accepted: 03/20/2025] [Indexed: 04/26/2025]  Open
33
Adams-Brown SE, Reid KZ. The Central FacilitaTOR: Coordinating Transcription and Translation in Eukaryotes. Int J Mol Sci 2025;26:2845. [PMID: 40243440 PMCID: PMC11989106 DOI: 10.3390/ijms26072845] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/31/2025] [Revised: 03/11/2025] [Accepted: 03/17/2025] [Indexed: 04/18/2025]  Open
34
Harrer DC, Lüke F, Pukrop T, Ghibelli L, Reichle A, Heudobler D. MEPED as salvage therapy for relapsed/refractory Hodgkin's lymphoma incorporating edited non-oncogene addiction: mTOR as a bottleneck. Front Pharmacol 2025;16:1553331. [PMID: 40183103 PMCID: PMC11965665 DOI: 10.3389/fphar.2025.1553331] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/30/2024] [Accepted: 02/24/2025] [Indexed: 04/05/2025]  Open
35
Jacinto E. Making sense of fat in cancer. Science 2025;387:1147-1148. [PMID: 40080596 DOI: 10.1126/science.adw1956] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 03/15/2025]
36
Hu Y, Wang K, Xu J, Wan G, Zhao Y, Chen Y, Jiang K, Li X. mTOR-Mediated Autophagy Regulates Cadmium-Induced Kidney Injury via Pyroptosis. Int J Mol Sci 2025;26:2589. [PMID: 40141229 PMCID: PMC11942160 DOI: 10.3390/ijms26062589] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/03/2025] [Revised: 02/17/2025] [Accepted: 02/22/2025] [Indexed: 03/28/2025]  Open
37
Ryspayeva D, Seyhan AA, MacDonald WJ, Purcell C, Roady TJ, Ghandali M, Verovkina N, El-Deiry WS, Taylor MS, Graff SL. Signaling pathway dysregulation in breast cancer. Oncotarget 2025;16:168-201. [PMID: 40080721 PMCID: PMC11906143 DOI: 10.18632/oncotarget.28701] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/20/2024] [Accepted: 03/03/2025] [Indexed: 03/15/2025]  Open
38
Zhou W, Sheng Y, Hu D, An Y, Yang M, Wang W, Basnet S, Yan J, Zhang S, Liu Q, Li Y, Tan Y, Gao J, Sun K, Du C. Proteasome inhibition induces DNA methylation alteration by attenuating the synthesis of DNA methyltransferase 1 and 3B in colorectal cancer. Sci Rep 2025;15:8534. [PMID: 40075132 PMCID: PMC11903776 DOI: 10.1038/s41598-025-92390-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/29/2024] [Accepted: 02/27/2025] [Indexed: 03/14/2025]  Open
39
Singh G, Rohit, Kumar P, Aran KR. Targeting EGFR and PI3K/mTOR pathways in glioblastoma: innovative therapeutic approaches. Med Oncol 2025;42:97. [PMID: 40064710 DOI: 10.1007/s12032-025-02652-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/20/2024] [Accepted: 02/24/2025] [Indexed: 03/29/2025]
40
Yu P, Zhao X, Zhou D, Wang S, Hu Z, Lian K, Zhang N, Duan P. The microRNA-mediated apoptotic signaling axis in male reproduction: a possible and targetable culprit in male infertility. Cell Biol Toxicol 2025;41:54. [PMID: 40038116 PMCID: PMC11880093 DOI: 10.1007/s10565-025-10006-w] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/05/2024] [Accepted: 02/20/2025] [Indexed: 03/06/2025]
41
Song Y, Wang F, Luo H, Hu H, Pang Y, Xu K, Zhang X. Rapamycin protects glucocorticoid-induced glaucoma model mice against trabecular meshwork fibrosis by suppressing mTORC1/2 signaling. Eur J Pharmacol 2025;990:177269. [PMID: 39805488 DOI: 10.1016/j.ejphar.2025.177269] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/07/2024] [Revised: 01/08/2025] [Accepted: 01/09/2025] [Indexed: 01/16/2025]
42
Huang Y, Gao Y, Lin Z, Miao H. Involvement of the ubiquitin-proteasome system in the regulation of the tumor microenvironment and progression. Genes Dis 2025;12:101240. [PMID: 39759114 PMCID: PMC11697063 DOI: 10.1016/j.gendis.2024.101240] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/29/2023] [Revised: 10/11/2023] [Accepted: 12/05/2023] [Indexed: 01/07/2025]  Open
43
James NR, O'Neill JS. Circadian Control of Protein Synthesis. Bioessays 2025;47:e202300158. [PMID: 39668398 PMCID: PMC11848126 DOI: 10.1002/bies.202300158] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/22/2024] [Revised: 11/22/2024] [Accepted: 11/25/2024] [Indexed: 12/14/2024]
44
Lanuza-Gracia P, Juan-Mateu J, Valcárcel J. Splice age: mTORC1-mediated RNA splicing in metabolism and ageing. Trends Cell Biol 2025;35:183-185. [PMID: 39843329 DOI: 10.1016/j.tcb.2025.01.001] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/23/2024] [Revised: 01/03/2025] [Accepted: 01/06/2025] [Indexed: 01/24/2025]
45
Hao Y, Li Z, Du X, Xie Q, Li D, Lei S, Guo Y. Characterization and chemoproteomic profiling of protein O-GlcNAcylation in SOD1-G93A mouse model. Mol Med 2025;31:82. [PMID: 40021952 PMCID: PMC11871760 DOI: 10.1186/s10020-025-01134-4] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/14/2024] [Accepted: 02/15/2025] [Indexed: 03/03/2025]  Open
46
Jefcoate CR, Larsen MC, Song YS, Maguire M, Sheibani N. Defined Diets Link Iron and α-Linolenic Acid to Cyp1b1 Regulation of Neonatal Liver Development Through Srebp Forms and LncRNA H19. Int J Mol Sci 2025;26:2011. [PMID: 40076634 PMCID: PMC11901102 DOI: 10.3390/ijms26052011] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/02/2024] [Revised: 01/10/2025] [Accepted: 01/15/2025] [Indexed: 03/14/2025]  Open
47
Klauer MJ, Hall KL, Jagla CAD, Tsvetanova NG. Extensive location bias of the GPCR-dependent translatome via site-selective activation of mTOR. Proc Natl Acad Sci U S A 2025;122:e2414738122. [PMID: 39964727 PMCID: PMC11874449 DOI: 10.1073/pnas.2414738122] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/23/2024] [Accepted: 01/13/2025] [Indexed: 02/20/2025]  Open
48
Fang Y, Zhang Y, Huang T, Yang S, Li Y, Zhou L. Focal cortical dysplasia type II: review of neuropathological manifestations and pathogenetic mechanisms. ACTA EPILEPTOLOGICA 2025;7:12. [PMID: 40217346 PMCID: PMC11960379 DOI: 10.1186/s42494-024-00195-y] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/30/2024] [Accepted: 11/22/2024] [Indexed: 04/15/2025]  Open
49
D'Amore A, Sundberg M, Lin R, Lubbers ET, Winden KD, Yu L, Gawlinska K, Gawlinski D, Lopez SG, Choe Y, Wightman EV, Liang Y, Modi M, Yuskaitis CJ, Lee HHC, Rotenberg A, Sahin M. Phenotypic rescue via mTOR inhibition in neuron-specific Pten knockout mice reveals AKT and mTORC1-site specific changes. Mol Psychiatry 2025:10.1038/s41380-025-02916-2. [PMID: 39953287 DOI: 10.1038/s41380-025-02916-2] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/29/2023] [Revised: 12/22/2024] [Accepted: 01/30/2025] [Indexed: 02/17/2025]
50
Rivera-Correa J, Gupta S, Ricker E, Flores-Castro D, Jenkins D, Vulcano S, Phalke SP, Pannellini T, Miele MM, Li Z, Zamponi N, Kim YB, Chinenov Y, Giannopoulou E, Cerchietti L, Pernis AB. ROCK1 promotes B cell differentiation and proteostasis under stress through the heme-regulated proteins, BACH2 and HRI. JCI Insight 2025;10:e180507. [PMID: 39903532 PMCID: PMC11949073 DOI: 10.1172/jci.insight.180507] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/11/2024] [Accepted: 01/28/2025] [Indexed: 02/06/2025]  Open
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