The aim of this study was to define the clinical and laboratory characteristics of patients operated on for primary hyperpatathyroidism (PHPT) at university hospitals in Türkiye, and to investigate the differences in the clinical presentations of the disease between different geographical regions.

Patients operated on for PHPT in the university hospitals of Türkiye were included in the study. The demographic, clinical, and laboratory findings and the operational data of the patients were investigated according to the whole country and to different geographical regions. Comparisons were performed according to whole country and regions.

A total of 1,162 cases were included in the study from different regions and 20 university hospitals. The mean age of patients was 52.4 ± 0.38 (mean ± standard error) in the general population of Türkiye. The rates of hypertension, urolithiasis, bone disease and 25-hydroxyvitamin D insufficiency were 35%, 18.6%, 67.6%, and 63%, respectively. The median parathormone (PTH), serum total calcium (Ca⁺²) and phosphorus value were 220 pg/mL (range, 70–2,500 pg/mL), 11.2 mg/dL (range, 9.5–11.2 mg/dL), and 2.4 mg/dL (range, 1–4.7 mg/dL), respectively. The median size of the adenomas resected was 16 mm (range, 4–70 mm). Significant differences were observed in the clinical and laboratory findings of the patients operated on due to PHPT between different geographical regions of Türkiye (P < 0.05).

The clinical and laboratory characteristics of the patients with PHPT in different geographical regions of Türkiye differ. Furthermore, the general findings of the cases in Türkiye give us a hint that the severity of the disease here is somewhere between Eastern and Western countries.

• Parathyroidectomy
• Primary hyperparathyroidism
• Turkey

• Adenoma/complications
• Adenoma/diagnostic imaging
• Adult
• Aged
• Chronic Disease
• False Positive Reactions
• Female
• Humans
• Iodide Peroxidase/immunology
• Luminescence
• Male
• Middle Aged
• Parathyroid Hormone/blood
• Parathyroid Neoplasms/complications
• Parathyroid Neoplasms/diagnostic imaging
• Prospective Studies
• Thyroglobulin/analysis
• Thyroglobulin/immunology
• Thyroid Gland/diagnostic imaging
• Thyroiditis/complications
• Thyroiditis/diagnostic imaging
• Ultrasonography

AIM: To evaluate the difference between the performance of the (CKD-EPI) and Modification of Diet in Renal Disease (MDRD) equations in cirrhotic patients.

METHODS: From Jan 2004 to Oct 2008, 4127 cirrhotic patients were reviewed. Patients with incomplete data with respect to renal function were excluded; thus, a total of 3791 patients were included in the study. The glomerular filtration rate (GFR) was estimated by the 4-variable MDRD (MDRD-4), 6-variable MDRD (MDRD-6), and CKD-EPI equations.

RESULTS: When serum creatinine was 0.7-6.8 mg/dL and 0.6-5.3 mg/dL in men and women, respectively, a significantly lower GFR was estimated by the MDRD-6 than by the CKD-EPI. Similar GFRs were calculated by both equations when creatinine was > 6.9 mg/dL and > 5.4 mg/dL in men and women, respectively. In predicting in-hospital mortality, estimated GFR obtained by the MDRD-6 showed better accuracy [81.72%; 95% confidence interval (CI), 0.94-0.95] than that obtained by the MDRD-4 (80.22%; 95%CI, 0.96-0.97), CKD-EPI (79.93%; 95%CI, 0.96-0.96), and creatinine (77.50%; 95%CI, 2.27-2.63).

CONCLUSION: GFR calculated by the 6-variable MDRD equation may be closer to the true GFR than that calculated by the CKD-EPI equation.

• Chronic Kidney Disease Epidemiology Collaboration
• Estimated glomerular filtration rate
• Liver cirrhosis
• Modification of Diet in Renal Disease
• Renal function

• Animals
• Bone and Bones/physiology
• Bone and Bones/physiopathology
• Endocrine Glands/physiology
• Endocrine Glands/physiopathology
• Endocrine System Diseases/diagnosis
• Endocrine System Diseases/epidemiology
• Endocrine System Diseases/physiopathology
• Endocrine System Diseases/therapy
• Humans
• Minerals/metabolism
• Reproduction