1
|
Takawy MW, Abdelmalek MF. Impact of Weight Loss on Metabolic Dysfunction Associated Steatohepatitis and Hepatic Fibrosis. Curr Diab Rep 2025; 25:23. [PMID: 39964660 DOI: 10.1007/s11892-025-01579-1] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Accepted: 02/10/2025] [Indexed: 05/10/2025]
Abstract
PURPOSE OF REVIEW This review highlights the impact of weight loss on metabolic dysfunction associated steatotic liver disease (MASLD), formally known as nonalcoholic fatty liver disease (NAFLD), and its progressive form of metabolic dysfunction associated steatohepatitis (MASH), formally known as nonalcoholic steatohepatitis (NASH). The effects of weight loss, as achieved through lifestyle modification, pharmacotherapy, bariatric surgery or endobariatric procedures on MASLD/MASH and hepatic fibrosis are discussed. RECENT FINDINGS Although foundational in the treatment of MASLD/MASH, weight loss through life-style modification is challenging for most patients to achieve and sustain long-term. In patients with MASLD/MASH, a multidisciplinary approach may facilitate success with lifestyle modification, individualized consideration of pharmacotherapies and/or surgical approaches that have potential to lend an improvement in MASLD/MASH. Effective and sustained weight loss improves hepatic steatosis, steatohepatitis and potentially hepatic fibrosis. Improvement in hepatic fibrosis can improve patient-related outcomes associated with complications of advanced hepatic fibrosis or cirrhosis in patients with MASLD/MASH. Identifying risk factors that influence MASLD/MASH and early implementation of therapeutic weight loss strategies may improve chronic liver injury and decrease risk for adverse clinical outcomes related to progressive hepatic fibrosis attributable to MASLD/MASH.
Collapse
Affiliation(s)
- Marina W Takawy
- Division of Gastroenterology & Hepatology, Department of Medicine, Mayo Clinic, Rochester Rochester, MN, 55905, USA
| | - Manal F Abdelmalek
- Division of Gastroenterology & Hepatology, Department of Medicine, Mayo Clinic, Rochester Rochester, MN, 55905, USA.
| |
Collapse
|
2
|
Jawara D, Lauer KV, Venkatesh M, Stalter LN, Hanlon B, Churpek MM, Funk LM. Using Machine Learning to Predict Weight Gain in Adults: an Observational Analysis From the All of Us Research Program. J Surg Res 2025; 306:43-53. [PMID: 39742657 PMCID: PMC11911080 DOI: 10.1016/j.jss.2024.11.042] [Citation(s) in RCA: 3] [Impact Index Per Article: 3.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 09/16/2024] [Revised: 10/31/2024] [Accepted: 11/21/2024] [Indexed: 01/04/2025]
Abstract
INTRODUCTION Obesity, defined as a body mass index ≥30 kg/m2, is a major public health concern in the United States. Preventative approaches are essential, but they are limited by an inability to accurately predict individuals at highest risk of weight gain. Our objective was to develop accurate weight gain prediction models using the National Institutes of Health All of Us dataset. We hypothesized that machine learning models using both electronic health record and behavioral survey data would outperform models using electronic health record data alone. METHODS The All of Us dataset was used to identify adults between 18 and 70 ys old with weight measurements 2 y apart between 2008 and 2022. Patients with a history of cancer, bariatric surgery, or pregnancy were excluded. Demographics, vital signs, laboratory results, comorbidities, and survey data (Alcohol Use Disorder Identification Test, Patient-Reported Outcomes Measurement Information System physical and mental health scores) were included as model parameters. Elastic net and XGBoost machine learning models were developed with and without survey data to predict ≥10% total body weight gain within 2 y. The data were split into a training sample (60%) and a testing sample (40%), and parameters were tuned using 10-fold cross-validation. Performance was compared using area under the receiver operating characteristic curves (AUCs). RESULTS Our cohort consisted of 34,715 patients (mean [SD] age 50.9 [13.4] y; 45.7% White; 55.3% female). Over a 2-y span, 10.4% of the cohort gained ≥10% total body weight. AUCs were 0.677 [95% DeLong confidence interval 0.665-0.688] for elastic net and 0.706 [0.695-0.717] for XGBoost. Incorporation of survey data did not improve predictability, with AUCs of 0.681 [0.669-0.692] and 0.705 [0.694-0.716], respectively. CONCLUSIONS Our machine learning weight gain prediction models had modest performance that was not improved by survey data. The addition of other All of Us variables, including genomic data, may be informative in future studies.
Collapse
Affiliation(s)
- Dawda Jawara
- Department of Surgery, University of Wisconsin, Madison, Wisconsin
| | - Kate V Lauer
- Department of Surgery, University of Wisconsin, Madison, Wisconsin
| | - Manasa Venkatesh
- Department of Surgery, University of Wisconsin, Madison, Wisconsin
| | - Lily N Stalter
- Department of Surgery, University of Wisconsin, Madison, Wisconsin
| | - Bret Hanlon
- Department of Surgery, University of Wisconsin, Madison, Wisconsin; Department of Biostatistics and Medical Informatics, University of Wisconsin, Madison, Wisconsin
| | | | - Luke M Funk
- Department of Surgery, University of Wisconsin, Madison, Wisconsin; Department of Surgery, William S. Middleton Memorial VA, Madison, Wisconsin.
| |
Collapse
|
3
|
Pérez LO, Ruderman A, Useglio M, Ramallo V, Paschetta C, de Azevedo S, Navarro P, Morales L, Trujillo-Jiménez MA, Pazos B, Teodoroff T, González-José R. Relationship between moderate alcohol consumption, genetic polymorphisms and body weight in a population sample of Puerto Madryn, Argentina. BIOMEDICA : REVISTA DEL INSTITUTO NACIONAL DE SALUD 2024; 44:510-523. [PMID: 39531551 PMCID: PMC11781604 DOI: 10.7705/biomedica.7270] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Subscribe] [Scholar Register] [Received: 10/31/2023] [Accepted: 07/31/2024] [Indexed: 11/16/2024]
Abstract
Introduction. The relationship between obesity and alcohol consumption is a topic of significant interest to public health. Alcoholic beverages contribute additional calories to the diet, which could be a relevant factor to the overweight risk. However, its association with weight gain is controversial and influenced by multiple factors. Objective. To analyze the relationship between moderate alcohol intake and body mass index, considering the variables that may influence this relationship. Materials and methods. The sample consisted of 155 individuals from Puerto Madryn (Argentina). Each participant completed a questionnaire about health, lifestyle, demographic, and socioeconomic factors. Anthropometric measurements were taken, and polymorphisms of 18 genes related to alcohol metabolism were genotyped. Results. We found that moderate alcohol consumption is associated with a lower body mass index, particularly in females. An increase of 14 grams of alcohol was associated with a risk of 0.68 for obesity and 0.71 for overweight. The T variant of the marker rs4646543 (ALDH1A1), a gene involved in alcohol metabolism and adipogenesis, was associated with a higher frequency of alcohol consumption. Conclusion. The findings of this study suggest that moderate alcohol consumption does not significantly contribute to body weight in the sample studied. Furthermore, the association with genetic variants, such as those of the ALDH1A1 gene, may provide a biological explanation for the inverse relationship observed between weight and alcohol consumption.
Collapse
Affiliation(s)
- Luis Orlando Pérez
- Instituto Patagónico de Ciencias Sociales y Humanas, CCT CENPAT-CONICET, Puerto Madryn, ArgentinaInstituto Patagónico de Ciencias Sociales y HumanasPuerto MadrynArgentina
- Programa de Referencia y Biobanco Genómico de la Población Argentina, Secretaría de Planeamiento y Políticas, Ministerio de Ciencia, Tecnología e Innovación, Ciudad Autónoma de Buenos Aires, ArgentinaSecretaría de Planeamiento y PolíticasBuenos AiresArgentina
| | - Anahí Ruderman
- Instituto Patagónico de Ciencias Sociales y Humanas, CCT CENPAT-CONICET, Puerto Madryn, ArgentinaInstituto Patagónico de Ciencias Sociales y HumanasPuerto MadrynArgentina
- Programa de Referencia y Biobanco Genómico de la Población Argentina, Secretaría de Planeamiento y Políticas, Ministerio de Ciencia, Tecnología e Innovación, Ciudad Autónoma de Buenos Aires, ArgentinaSecretaría de Planeamiento y PolíticasBuenos AiresArgentina
| | - Mariana Useglio
- Instituto Patagónico de Ciencias Sociales y Humanas, CCT CENPAT-CONICET, Puerto Madryn, ArgentinaInstituto Patagónico de Ciencias Sociales y HumanasPuerto MadrynArgentina
- Programa de Referencia y Biobanco Genómico de la Población Argentina, Secretaría de Planeamiento y Políticas, Ministerio de Ciencia, Tecnología e Innovación, Ciudad Autónoma de Buenos Aires, ArgentinaSecretaría de Planeamiento y PolíticasBuenos AiresArgentina
| | - Virginia Ramallo
- Instituto Patagónico de Ciencias Sociales y Humanas, CCT CENPAT-CONICET, Puerto Madryn, ArgentinaInstituto Patagónico de Ciencias Sociales y HumanasPuerto MadrynArgentina
- Programa de Referencia y Biobanco Genómico de la Población Argentina, Secretaría de Planeamiento y Políticas, Ministerio de Ciencia, Tecnología e Innovación, Ciudad Autónoma de Buenos Aires, ArgentinaSecretaría de Planeamiento y PolíticasBuenos AiresArgentina
| | - Carolina Paschetta
- Instituto Patagónico de Ciencias Sociales y Humanas, CCT CENPAT-CONICET, Puerto Madryn, ArgentinaInstituto Patagónico de Ciencias Sociales y HumanasPuerto MadrynArgentina
- Programa de Referencia y Biobanco Genómico de la Población Argentina, Secretaría de Planeamiento y Políticas, Ministerio de Ciencia, Tecnología e Innovación, Ciudad Autónoma de Buenos Aires, ArgentinaSecretaría de Planeamiento y PolíticasBuenos AiresArgentina
| | - Soledad de Azevedo
- Instituto Patagónico de Ciencias Sociales y Humanas, CCT CENPAT-CONICET, Puerto Madryn, ArgentinaInstituto Patagónico de Ciencias Sociales y HumanasPuerto MadrynArgentina
- Programa de Referencia y Biobanco Genómico de la Población Argentina, Secretaría de Planeamiento y Políticas, Ministerio de Ciencia, Tecnología e Innovación, Ciudad Autónoma de Buenos Aires, ArgentinaSecretaría de Planeamiento y PolíticasBuenos AiresArgentina
| | - Pablo Navarro
- Instituto Patagónico de Ciencias Sociales y Humanas, CCT CENPAT-CONICET, Puerto Madryn, ArgentinaInstituto Patagónico de Ciencias Sociales y HumanasPuerto MadrynArgentina
- Programa de Referencia y Biobanco Genómico de la Población Argentina, Secretaría de Planeamiento y Políticas, Ministerio de Ciencia, Tecnología e Innovación, Ciudad Autónoma de Buenos Aires, ArgentinaSecretaría de Planeamiento y PolíticasBuenos AiresArgentina
- Laboratorio de Ciencias de las Imágenes, Departamento de Ingeniería Eléctrica y Computadoras, Universidad Nacional del Sur, Bahía Blanca, Buenos Aires, ArgentinaUniversidad Nacional del SurDepartamento de Ingeniería Eléctrica y ComputadorasUniversidad Nacional del SurBuenos AiresArgentina
- Departamento de Informática, Facultad de Ingeniería, Universidad Nacional de la Patagonia San Juan Bosco, Trelew, ArgentinaUniversidad Nacional de la Patagonia San Juan BoscoDepartamento de InformáticaFacultad de IngenieríaUniversidad Nacional de la Patagonia San Juan BoscoTrelewArgentina
| | - Leonardo Morales
- Instituto Patagónico de Ciencias Sociales y Humanas, CCT CENPAT-CONICET, Puerto Madryn, ArgentinaInstituto Patagónico de Ciencias Sociales y HumanasPuerto MadrynArgentina
- Programa de Referencia y Biobanco Genómico de la Población Argentina, Secretaría de Planeamiento y Políticas, Ministerio de Ciencia, Tecnología e Innovación, Ciudad Autónoma de Buenos Aires, ArgentinaSecretaría de Planeamiento y PolíticasBuenos AiresArgentina
- Laboratorio de Ciencias de las Imágenes, Departamento de Ingeniería Eléctrica y Computadoras, Universidad Nacional del Sur, Bahía Blanca, Buenos Aires, ArgentinaUniversidad Nacional del SurDepartamento de Ingeniería Eléctrica y ComputadorasUniversidad Nacional del SurBuenos AiresArgentina
- Departamento de Informática, Facultad de Ingeniería, Universidad Nacional de la Patagonia San Juan Bosco, Trelew, ArgentinaUniversidad Nacional de la Patagonia San Juan BoscoDepartamento de InformáticaFacultad de IngenieríaUniversidad Nacional de la Patagonia San Juan BoscoTrelewArgentina
| | - Magda Alexandra Trujillo-Jiménez
- Instituto Patagónico de Ciencias Sociales y Humanas, CCT CENPAT-CONICET, Puerto Madryn, ArgentinaInstituto Patagónico de Ciencias Sociales y HumanasPuerto MadrynArgentina
| | - Bruno Pazos
- Instituto Patagónico de Ciencias Sociales y Humanas, CCT CENPAT-CONICET, Puerto Madryn, ArgentinaInstituto Patagónico de Ciencias Sociales y HumanasPuerto MadrynArgentina
- Programa de Referencia y Biobanco Genómico de la Población Argentina, Secretaría de Planeamiento y Políticas, Ministerio de Ciencia, Tecnología e Innovación, Ciudad Autónoma de Buenos Aires, ArgentinaSecretaría de Planeamiento y PolíticasBuenos AiresArgentina
- Laboratorio de Ciencias de las Imágenes, Departamento de Ingeniería Eléctrica y Computadoras, Universidad Nacional del Sur, Bahía Blanca, Buenos Aires, ArgentinaUniversidad Nacional del SurDepartamento de Ingeniería Eléctrica y ComputadorasUniversidad Nacional del SurBuenos AiresArgentina
- Departamento de Informática, Facultad de Ingeniería, Universidad Nacional de la Patagonia San Juan Bosco, Trelew, ArgentinaUniversidad Nacional de la Patagonia San Juan BoscoDepartamento de InformáticaFacultad de IngenieríaUniversidad Nacional de la Patagonia San Juan BoscoTrelewArgentina
| | - Tamara Teodoroff
- Instituto Patagónico de Ciencias Sociales y Humanas, CCT CENPAT-CONICET, Puerto Madryn, ArgentinaInstituto Patagónico de Ciencias Sociales y HumanasPuerto MadrynArgentina
| | - Rolando González-José
- Instituto Patagónico de Ciencias Sociales y Humanas, CCT CENPAT-CONICET, Puerto Madryn, ArgentinaInstituto Patagónico de Ciencias Sociales y HumanasPuerto MadrynArgentina
- Programa de Referencia y Biobanco Genómico de la Población Argentina, Secretaría de Planeamiento y Políticas, Ministerio de Ciencia, Tecnología e Innovación, Ciudad Autónoma de Buenos Aires, ArgentinaSecretaría de Planeamiento y PolíticasBuenos AiresArgentina
| |
Collapse
|
4
|
Verma A, Malhotra A, Ranjan P, Kumari A, Chopra S, Khan MA, Kaloiya GS, Singh A, Prakash B, Ahuja M. A comprehensive evaluation of predictors of obesity in women during the perimenopausal period: A systematic review and narrative synthesis. Diabetes Metab Syndr 2024; 18:102933. [PMID: 38181722 DOI: 10.1016/j.dsx.2023.102933] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 07/13/2023] [Revised: 11/16/2023] [Accepted: 12/17/2023] [Indexed: 01/07/2024]
Abstract
INTRODUCTION Obesity during perimenopausal transition can be attributed to various factors. Identifying these factors is crucial in preventing obesity and developing effective strategies to manage weight during this phase. This review aimed to systematically understand predictors of obesity during menopausal transition. METHODS The review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and searched databases like PubMed, Wiley Online Library, and Cochrane Reviews. Cohort and cross-sectional studies in English language assessing obesity among menopausal women were included. The methodological quality was assessed using Joanna Briggs Checklist for critical appraisal. Risk of Bias (RoB) was generated using Review Manager 5.4.1 (RevMan). Identified predictors were assessed for overall quality of evidence using adopted Grading of Recommendations Assessment, Development and Evaluation (GRADE) approach. RESULTS This review encompassed 42 studies, (21 cross-sectional and 21 cohort) with sample ranging from 164 to 107,243 across studies. Higher parity( ≥ 3 children) emerged as a strong predictor of obesity across seven studies, with good-quality evidence. Lower physical activity was another predictor, supported by eight studies with good-quality evidence. Sociodemographic factors like lower education(<8 years or < than college degree), socioeconomic background, menopausal transition, and older age at menarche showed associations with weight gain, with moderate-quality evidence. Lifestyle factors (high-fat consumption, sedentariness, active smoking status, and psychological difficulties) also showed moderate-quality evidence. CONCLUSION This review underscores the multifaceted factors associated with obesity during the perimenopausal transition. Identifying these factors will be helpful in prevention and management of obesity among these women.
Collapse
Affiliation(s)
- Aditi Verma
- Department of Home Science, University of Delhi, New Delhi, India
| | - Anita Malhotra
- Lakshmibai College, Department of Home Science, University of Delhi, New Delhi, India
| | - Piyush Ranjan
- Department of Medicine, All India Institute of Medical Sciences, New Delhi, India.
| | - Archana Kumari
- Department of Obstetrics and Gynaecology, AIIMS, New Delhi, India
| | - Sakshi Chopra
- Department of Home Science, University of Delhi, New Delhi, India
| | - Maroof A Khan
- Department of Biostatistics, All India Institute of Medical Sciences, New Delhi, India
| | | | - Amandeep Singh
- Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
| | - Bindu Prakash
- Department of Medicine, All India Institute of Medical Sciences, New Delhi, India
| | - Maninder Ahuja
- Indian Menopause Society, Society of Meaningful Life Management, India
| |
Collapse
|
5
|
Llamosas-Falcón L, Rehm J, Bright S, Buckley C, Carr T, Kilian C, Lasserre AM, Lemp JM, Zhu Y, Probst C. The Relationship Between Alcohol Consumption, BMI, and Type 2 Diabetes: A Systematic Review and Dose-Response Meta-analysis. Diabetes Care 2023; 46:2076-2083. [PMID: 37890103 PMCID: PMC10620538 DOI: 10.2337/dc23-1015] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 06/01/2023] [Accepted: 08/26/2023] [Indexed: 10/29/2023]
Abstract
BACKGROUND Moderate alcohol use may be associated with lower risk of type 2 diabetes mellitus (T2DM). Previous reviews have reached mixed conclusions. PURPOSE To quantify the dose-response relationship between alcohol consumption and T2DM, accounting for differential effects by sex and BMI. DATA SOURCES Medline, Embase, Web of Science, and one secondary data source. STUDY SELECTION Cohort studies on the relationship between alcohol use and T2DM. DATA EXTRACTION Fifty-five studies, and one secondary data source, were included with a combined sample size of 1,363,355 men and 1,290,628 women, with 89,983 and 57,974 individuals, respectively, diagnosed with T2DM. DATA SYNTHESIS Multivariate dose-response meta-analytic random-effect models were used. For women, a J-shaped relationship was found with a maximum risk reduction of 31% (relative risk [RR] 0.69, 95% CI 0.64-0.74) at an intake of 16 g of pure alcohol per day compared with lifetime abstainers. The protective association ceased above 49 g per day (RR 0.82, 95% CI 0.68-0.99). For men, no statistically significant relationship was identified. When results were stratified by BMI, the protective association was only found in overweight and obese women. LIMITATIONS Our analysis relied on aggregate data. We included some articles that determined exposure and cases via self-report, and the studies did not account for temporal variations in alcohol use. CONCLUSIONS The observed reduced risk seems to be specific to women in general and women with a BMI ≥25 kg/m2. Our findings allow for a more precise prediction of the sex-specific relationship between T2DM and alcohol use, as our results differ from those of previous studies.
Collapse
Affiliation(s)
- Laura Llamosas-Falcón
- Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
| | - Jürgen Rehm
- Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
- Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
- Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
- Dalla Lana School of Public Health, University of Toronto, Toronto, Ontario, Canada
- Institute of Clinical Psychology and Psychotherapy & Center of Clinical Epidemiology and Longitudinal Studies (CELOS), Technische Universität Dresden, Dresden, Germany
- Center for Interdisciplinary Addiction Research (ZIS), Department of Psychiatry and Psychotherapy, University Medical Center Hamburg-Eppendorf, Hamburg, Germany
- Institute of Medical Science, University of Toronto, Toronto, Ontario, Canada
| | - Sophie Bright
- School of Health and Related Research (ScHARR), Faculty of Medicine, Dentistry & Health, University of Sheffield, Sheffield, U.K
| | - Charlotte Buckley
- Department of Automatic Control and Systems Engineering, University of Sheffield, Sheffield, U.K
| | - Tessa Carr
- Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
| | - Carolin Kilian
- Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
| | - Aurélie M. Lasserre
- Addiction Medicine, Department of Psychiatry, Lausanne University Hospital, Lausanne, Switzerland
| | - Julia M. Lemp
- Heidelberg Institute of Global Health, Medical Faculty and University Hospital, University of Heidelberg, Heidelberg, Germany
| | - Yachen Zhu
- Alcohol Research Group, Public Health Institute, Emeryville, CA
| | - Charlotte Probst
- Institute for Mental Health Policy Research, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
- Campbell Family Mental Health Research Institute, Centre for Addiction and Mental Health, Toronto, Ontario, Canada
- Department of Psychiatry, University of Toronto, Toronto, Ontario, Canada
- Heidelberg Institute of Global Health, Medical Faculty and University Hospital, University of Heidelberg, Heidelberg, Germany
| |
Collapse
|
6
|
Wojtowicz JS. Long-Term Health Outcomes of Regular, Moderate Red Wine Consumption. Cureus 2023; 15:e46786. [PMID: 37954791 PMCID: PMC10634232 DOI: 10.7759/cureus.46786] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Accepted: 10/09/2023] [Indexed: 11/14/2023] Open
Abstract
Studies that are conducted to assess alcohol's long-term health outcomes generally report the results as a pooled analysis across all types of alcohol. Questions have been raised regarding potential health differences between types of alcohol, such as beer, wine, or spirits. While these three share the same alcohol in the form of ethanol, they differ in the other compounds they contain that are particular to each type of alcohol, specifically the polyphenols in red wine. The generalizability of pooled results may be limited due to the differences in health outcomes that may exist between different types of alcohol and lead to overall conclusions that differ from the subset analysis by type of alcohol that is often reported in the data tables of an article. The objective of this systematic review was to specifically address the assessment of the long-term health outcomes of regular, moderate, red wine consumption. PubMed was searched from 1987 through June 2023. Studies were included if they met all the following criteria: adult participants, red wine consumption and its frequency (close to daily), volume in moderation (1 glass/day for women, 2 glasses/day for men), and measurement of long-term (> 2 years) health outcomes. Nonclinical animal studies, or studies with an endpoint as a marker or biomarker, without a health outcome, of short duration (< 2 years), small size (< 25 subjects), a focus on binge drinking, no wine analysis performed, review articles, meta-analysis, or editorial/commentary were excluded. A total of 74 studies met the inclusion/exclusion criteria. Of these, 27 (36%) evaluated cancer outcomes, 14 (19%) evaluated cardiovascular outcomes, 10 (14%) evaluated mortality, 7 (9%) evaluated weight gain, 5 (7%) evaluated dementia, and the remaining 11 evaluated a variety of health outcomes. There were no studies that demonstrated an association between red wine consumption and negative health outcomes. Forty-seven studies demonstrated an association between red wine consumption and positive health outcomes, whereas 26 studies were neutral, and one had mixed results where women had a positive health outcome and men were neutral. All studies on mortality and dementia showed positive health outcomes. From this systematic review of the literature, there is no evidence of an association between moderate red wine consumption and negative health outcomes. Across the various outcomes assessed, a beneficial effect of moderate red wine consumption was consistently seen for mortality and dementia, along with certain cancers (e.g., non-Hodgkin lymphoma) and cardiovascular conditions (e.g., metabolic syndrome). For other health outcomes, the association was neutral, i.e., neither harmful nor beneficial. This review is not intended to encourage red wine consumption for health outcomes but rather to avoid discouraging moderate red wine consumption based on misunderstanding or misinterpretation of the red wine data due to the reporting of pooled data across all types of alcohol.
Collapse
|
7
|
Raza SA, Sokale IO, Thrift AP. Burden of high-risk phenotype of heavy alcohol consumption among obese U.S. population: results from National Health and Nutrition Examination Survey, 1999-2020. LANCET REGIONAL HEALTH. AMERICAS 2023; 23:100525. [PMID: 37293391 PMCID: PMC10245110 DOI: 10.1016/j.lana.2023.100525] [Citation(s) in RCA: 11] [Impact Index Per Article: 5.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 11/21/2022] [Revised: 05/16/2023] [Accepted: 05/17/2023] [Indexed: 06/10/2023]
Abstract
Background The phenotype of combined heavy alcohol consumption and obesity has the potential to pose as a considerable health burden in the U.S. No studies using nationally representative data in the U.S. have reported their secular joint prevalence trends. We estimated the prevalence and examined the joint trends of heavy alcohol use and obesity over time among adult U.S. men and women in different age groups and according to race/ethnicity. Methods Using data from 10 cycles of the U.S. National Health and Nutrition Examination Survey (NHANES) from 1999 to 2020, we examined secular trends in the combined phenotype of heavy drinking and obesity overall and by age-group, sex, and race/ethnicity. The main outcome measures were prevalence of heavy alcohol consumption (>14 drinks/week in men and >7 drinks/week in women) and obesity (BMI ≥30). Findings In 45,292 adults (22,684 men, mean age 49.26 years; and 22,608 women, mean age 49.86), the overall weighted prevalence of combined heavy alcohol drinking and obesity increased from 1.8% (95% CI: 1.2%, 3.1%) in 1999-2000 to 3.1% (95% CI: 2.7%, 3.7%) in 2017-2020 representing an increase of 72% over time. In the joinpoint regression, the combined phenotype of heavy alcohol consumption and obesity increased by 3.25% (95% CI: 1.67%, 4.85%) per year overall from 1999 to 2017. An increasing trend of 9.94% (95% CI: 2.37%, 18.06%) per year was observed among adults aged between 40 and 59 years from 2007 onwards. Prevalence of heavy alcohol consumption in obesity increased at a faster rate among women (APC, 3.96%; 95% CI: 2.14%, 5.82%) than men (APC, 2.47%; 95% CI: 0.63%, 4.35%), and increased among non-Hispanic Whites (APC, 4.12%; 95% CI: 1.50%, 6.82%) and non-Hispanic Blacks (APC, 2.78%; 95% CI: 0.47%, 5.14%), but not Hispanics. Interpretation The prevalence of combined heavy alcohol consumption and obesity increased overall in the U.S., but the rate of increase differed by age, sex, and race/ethnic groups. Given their independent and potential synergistic effects on premature mortality, public health policies on alcohol consumption need to reflect the background obesity epidemic. Funding Cancer Prevention & Research Institute of Texas (CPRIT) for the Systems Epidemiology of Cancer Training (SECT) Program (RP210037; PI: A. Thrift).
Collapse
Affiliation(s)
- Syed Ahsan Raza
- Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
| | - Itunu O. Sokale
- Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
| | - Aaron P. Thrift
- Section of Epidemiology and Population Sciences, Department of Medicine, Baylor College of Medicine, Houston, TX 77030, USA
- Dan L. Duncan Comprehensive Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA
| |
Collapse
|
8
|
Drouard G, Silventoinen K, Latvala A, Kaprio J. Genetic and Environmental Factors Underlying Parallel Changes in Body Mass Index and Alcohol Consumption: A 36-Year Longitudinal Study of Adult Twins. Obes Facts 2023; 16:224-236. [PMID: 36882010 PMCID: PMC10826601 DOI: 10.1159/000529835] [Citation(s) in RCA: 4] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/29/2022] [Accepted: 02/17/2023] [Indexed: 03/09/2023] Open
Abstract
INTRODUCTION While the genetic and environmental underpinnings of body weight and alcohol use are fairly well-known, determinants of simultaneous changes in these traits are still poorly known. We sought to quantify the environmental and genetic components underlying parallel changes in weight and alcohol consumption and to investigate potential covariation between them. METHODS The analysis comprised 4,461 adult participants (58% women) from the Finnish Twin Cohort with four measures of alcohol consumption and body mass index (BMI) over a 36-year follow-up. Trajectories of each trait were described by growth factors, defined as intercepts (i.e., baseline) and slopes (i.e., change over follow-up), using latent growth curve modeling. Growth values were used for male (190 monozygotic pairs, 293 dizygotic pairs) and female (316 monozygotic pairs, 487 dizygotic pairs) same-sex complete twin pairs in multivariate twin modeling. The variances and covariances of growth factors were then decomposed into genetic and environmental components. RESULTS The baseline heritabilities were similar in men (BMI: h2 = 79% [95% confidence interval: 74, 83]; alcohol consumption: h2 = 49% [32, 67]) and women (h2 = 77% [73, 81]; h2 = 45% [29, 61]). Heritabilities of BMI change were similar in men (h2 = 52% [42, 61]) and women (h2 = 57% [50, 63]), but the heritability of change in alcohol consumption was significantly higher (p = 0.03) in men (h2 = 45% [34, 54]) than in women (h2 = 31% [22, 38]). Significant additive genetic correlations between BMI at baseline and change in alcohol consumption were observed in both men (rA = -0.17 [-0.29, -0.04]) and women (rA = -0.18 [-0.31, -0.06]). Non-shared environmental factors affecting changes in alcohol consumption and BMI were correlated in men (rE = 0.18 [0.06, 0.30]). Among women, non-shared environmental factors affecting baseline alcohol consumption and the change in BMI were inversely correlated (rE = -0.11 [-0.20, -0.01]). CONCLUSIONS Based on genetic correlations, genetic variation underlying BMI may affect changes in alcohol consumption. Independent of genetic effects, change in BMI correlates with change in alcohol consumption in men, suggesting direct effects between them.
Collapse
Affiliation(s)
- Gabin Drouard
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland
| | - Karri Silventoinen
- Population Research Unit, Faculty of Social Sciences, University of Helsinki, Helsinki, Finland
- Department of Public Health, Faculty of Medicine, University of Helsinki, Helsinki, Finland
| | - Antti Latvala
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland
- Institute of Criminology and Legal Policy, University of Helsinki, Helsinki, Finland
| | - Jaakko Kaprio
- Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Helsinki, Finland
| |
Collapse
|
9
|
Butler JL, Gordon-Larsen P, Steffen LM, Shikany JM, Jacobs DR, Popkin BM, Poti JM. Associations of 5-year changes in alcoholic beverage intake with 5-year changes in waist circumference and BMI in the Coronary Artery Risk Development in Young Adults (CARDIA) study. PLoS One 2023; 18:e0281722. [PMID: 36888592 PMCID: PMC9994756 DOI: 10.1371/journal.pone.0281722] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/11/2022] [Accepted: 01/30/2023] [Indexed: 03/09/2023] Open
Abstract
OBJECTIVE This study aimed to shed light on contradictory associations of alcohol intake with waist circumference (WC) and body mass index (BMI) by examining 5-yr changes in alcohol intake in relation to 5-yr WC and BMI changes. METHODS This prospective study included 4,355 participants (1,974 men and 2,381 women) enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) study at baseline (1985-1986) and followed over 25 years (2010-2011). Longitudinal random effects linear regression models were used to test whether changes in drinking (defined categorically) as starting to drink, increasing, decreasing, stable drinking or stopping drinking (versus stable non-drinking) over a series of 5-yr periods were associated with corresponding 5-yr WC and BMI changes. Associations with 5-yr changes (defined categorically as starting, stable or stopping) in drinking level (i.e., light/moderate and excessive) and 5-yr changes (defined categorically as increasing, no change, or decreasing) by beverage type (i.e., beer, wine and liquor/mixed drinks) were also examined. RESULTS In men, compared to stable non-drinking, decreasing total alcohol intake was associated with lower 5-yr WC (β:-0.62 cm; 95% CI: -1.09, -0.14 cm) and BMI gains (β:-0.20 kg/m2; 95% CI: -0.30, -0.03 kg/m2) and stopping excessive drinking was associated with lower 5-yr WC gains (β:-0.77 cm; 95% CI: -1.51, -0.03 cm). In women, compared to those with stable non-drinking habits, starting light/moderate drinking was associated with lower 5-yr WC (β: -0.78 cm; 95% CI: -1.29, -0.26 cm) and BMI gains (β:-0.42 kg/m2; 95% CI: -0.64, -0.20 kg/m2). Increasing wine intake was associated with a lower 5-yr BMI gain (β:-0.27 kg/m2; 95% CI: -0.51, -0.03 kg/m2). Decreasing liquor/mixed drink (β:-0.33 kg/m2; 95% CI: -0.56, -0.09 kg/m2) intake was associated with lower 5-yr WC (β:-0.88 cm; 95% CI: -1.43, -0.34 cm) and BMI (β:-0.33 kg/m2; 95% CI: -0.56, -0.09 kg/m2) gains. CONCLUSIONS Associations of alcohol intake with obesity measures are complex. In women, wine and liquor/mixed drink intakes had contrasting associations with WC and BMI change. In men, decreasing weekly alcoholic beverage intake with an emphasis on stopping excessive consumption may be beneficial in managing WC and BMI gains.
Collapse
Grants
- HHSN268201800005I NHLBI NIH HHS
- HHSN268201800007I NHLBI NIH HHS
- HHSN268201800003I NHLBI NIH HHS
- HHSN268201800006I NHLBI NIH HHS
- HHSN268201800004I NHLBI NIH HHS
- R01 HL104580 NHLBI NIH HHS
- R01 DK098072 NIDDK NIH HHS
- T32 DK007686 NIDDK NIH HHS
- P2C HD050924 NICHD NIH HHS
- National Heart, Lung, and Blood Institute in collaboration with the University of Alabama at Birmingham
- National Heart, Lung, and Blood Institute in collaboration with Northwestern University
- National Heart, Lung, and Blood Institute in collaboration with the University of Minnesota
- National Heart, Lung, and Blood Institute in collaboration with the Kaiser Foundation Research Institute
- National Institutes of Health, NIH,
- National Institutes of Health
- Eunice Kennedy Shriver National Institute of Child Health and Human Development
Collapse
Affiliation(s)
- J. Lauren Butler
- Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
- Nutrition and Foods Program, School of Family and Consumer Sciences, Texas State University, San Marcos, Texas, United States of America
- * E-mail:
| | - Penny Gordon-Larsen
- Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
| | - Lyn M. Steffen
- Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America
| | - James M. Shikany
- Division of Preventive Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States of America
| | - David R. Jacobs
- Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, United States of America
| | - Barry M. Popkin
- Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
| | - Jennifer M. Poti
- Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, United States of America
| |
Collapse
|
10
|
Evaluation of the effect of alpha-tocopherol on anxiety and the neuroinflammatory process during alcohol withdrawal in a model of forced and chronic self-administration of liquid diet containing ethanol: Behavioral and neurochemical evidence. Alcohol 2022; 104:31-44. [PMID: 35987315 DOI: 10.1016/j.alcohol.2022.08.002] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 12/03/2021] [Revised: 07/13/2022] [Accepted: 08/06/2022] [Indexed: 01/26/2023]
Abstract
Alcoholism affects about 2 billion people worldwide. Withdrawal causes a neuroinflammatory response that increases anxiety. α-tocopherol is the most important antioxidant that has its in vivo action currently known. Therefore, this study aimed to evaluate the effect of α-tocopherol on the neuroinflammatory process in brain regions involved in anxiety and its anxiolytic potential during alcohol withdrawal. For this, male Wistar rats were divided into four groups and submitted to a procedure of forced and chronic self-administration of liquid diet containing 6% and 8% ethanol for 15 days, followed by abrupt interruption of treatment. Animals in the control group received the liquid diet without ethanol. Twenty-four or 48 h after ethanol discontinuation, and 30 min after the last administration of α-tocopherol or saline, animals were evaluated in the elevated plus maze, light/dark box, and open field tests. At the end of the tests, each experimental group underwent brain tissue collection for analysis of cytokine levels. The results showed that: alcohol induces the neuroinflammatory process and anxiety; the stress generated by withdrawal can induce oxidative stress, which alters the production of inflammatory cytokines in the amygdaloid nuclei (AN) and medial hypothalamic nucleus (mHN); α-tocopherol exhibited anxiolytic and anti-inflammatory activity, attenuating the anxious behavior of abstinent animals and reducing neuroinflammation in AN and mHN; and the intensity of the anxiolytic and anti-inflammatory effect of α-tocopherol is dose-dependent. These results identify α-tocopherol as a potential therapeutic target supporting the fight against relapse during alcohol withdrawal.
Collapse
|
11
|
Larsen BA, Klinedinst BS, Le ST, Pappas C, Wolf T, Meier NF, Lim Y, Willette AA. Beer, wine, and spirits differentially influence body composition in older white adults-a United Kingdom Biobank study. Obes Sci Pract 2022; 8:641-656. [PMID: 36238230 PMCID: PMC9535674 DOI: 10.1002/osp4.598] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.7] [Reference Citation Analysis] [Abstract] [Key Words] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/15/2021] [Revised: 01/30/2022] [Accepted: 02/01/2022] [Indexed: 11/30/2022] Open
Abstract
BACKGROUND Aging is characterized by body composition alterations, including increased visceral adiposity accumulation and bone loss. Alcohol consumption may partially drive these alterations, but findings are mixed. This study primarily aimed to investigate whether different alcohol types (beer/cider, red wine, white wine/Champagne, spirits) differentially associated with body composition. METHODS The longitudinal UK Biobank study leveraged 1869 White participants (40-80 years; 59% male). Participants self-reported demographic, alcohol/dietary consumption, and lifestyle factors using a touchscreen questionnaire. Anthropometrics and serum for proteomics were collected. Body composition was obtained via dual-energy X-ray absorptiometry. Structural equation modeling was used to probe direct/indirect associations between alcohol types, cardiometabolic biomarkers, and body composition. RESULTS Greater beer/spirit consumptions were associated with greater visceral adiposity (β = 0.069, p < 0.001 and β = 0.014, p < 0.001, respectively), which was driven by dyslipidemia and insulin resistance. In contrast, drinking more red wine was associated with less visceral adipose mass (β = -0.023, p < 0.001), which was driven by reduced inflammation and elevated high-density lipoproteins. White wine consumption predicted greater bone density (β = 0.051, p < 0.005). DISCUSSION Beer/spirits may partially contribute to the "empty calorie" hypothesis related to adipogenesis, while red wine may help protect against adipogenesis due to anti-inflammatory/eulipidemic effects. Furthermore, white wine may benefit bone health in older White adults.1.
Collapse
Affiliation(s)
- Brittany A. Larsen
- Neuroscience Graduate ProgramIowa State UniversityAmesIowaUSA
- Department of Biomedical SciencesCollege of Veterinary MedicineIowa State UniversityAmesIowaUSA
| | - Brandon S. Klinedinst
- Neuroscience Graduate ProgramIowa State UniversityAmesIowaUSA
- Department of Food Science and Human NutritionIowa State UniversityAmesIowaUSA
| | - Scott T. Le
- Department of Food Science and Human NutritionIowa State UniversityAmesIowaUSA
| | - Colleen Pappas
- Department of Food Science and Human NutritionIowa State UniversityAmesIowaUSA
| | - Tovah Wolf
- Department of Health SciencesWestern Carolina UniversityCullowheeNorth CarolinaUSA
| | - Nathan F. Meier
- Department of KinesiologyConcordia UniversityIrvineCaliforniaUSA
| | - Ye‐Lim Lim
- Department of PsychologyVirginia Polytechnic InstituteBlacksburgVirginiaUSA
| | - Auriel A. Willette
- Neuroscience Graduate ProgramIowa State UniversityAmesIowaUSA
- Department of Biomedical SciencesCollege of Veterinary MedicineIowa State UniversityAmesIowaUSA
- Department of Food Science and Human NutritionIowa State UniversityAmesIowaUSA
- Department of NeurologyUniversity of IowaIowa CityIowaUSA
| |
Collapse
|
12
|
Inan-Eroglu E, Huang BH, Hamer M, Britton A, Stamatakis E. Alcohol Consumption and Adiposity: A Longitudinal Analysis of 45,399 UK Biobank Participants. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2022; 19:11945. [PMID: 36231244 PMCID: PMC9565835 DOI: 10.3390/ijerph191911945] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Figures] [Subscribe] [Scholar Register] [Received: 08/22/2022] [Revised: 09/12/2022] [Accepted: 09/14/2022] [Indexed: 06/16/2023]
Abstract
The evidence on the association between alcohol consumption and adiposity is inconsistent and fragmented. We investigated the longitudinal association between alcohol consumption pattern and four different adiposity markers with repeated measures of adiposity and obesity incidence. We categorized current drinkers based on the sex-specific quartiles of their weekly alcohol consumption and the UK alcohol drinking guidelines. We used multivariable adjusted generalised linear models. With the exception of a direct association between alcohol volume and body fat percentage (BF%) in women (B = 0.42%; 95%CI: 0.04, 0.80% for women in the top quartile), we found no associations between alcohol consumption and adiposity markers for either sex. Red wine and champagne/white wine consumption were inversely associated with waist circumference (WC) for both sexes (B = -0.58 cm, 95%CI: -0.77, -0.38 cm and B= -0.49 cm, 95%CI: -0.68, -0.29 cm, respectively, for women; B = -0.28 cm, 95%CI: -0.47, -0.08 cm and B = -0.23 cm, 95%CI: -0.42, -0.04 cm, respectively, for men). Female and male spirit drinkers had higher WC than non-spirit drinkers. Alcohol consumption was associated with a lower risk of obesity incidence in women (OR:0.60, 95%CI:0.45, 0.80 for the 2nd quartile, OR:0.53, 95%CI: 0.40, 0.70 for the 3rd quartile and OR:0.61, 95%CI:0.46, 0.80 for the 4th quartile). We found limited evidence of longitudinal associations between alcohol intake and adiposity. The few statistically significant associations we observed are unlikely to be of clinical importance.
Collapse
Affiliation(s)
- Elif Inan-Eroglu
- Charles Perkins Centre, Faculty of Medicine and Health, School of Health Sciences, The University of Sydney, Sydney, NSW 2050, Australia
- Department of Molecular Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, 14558 Nuthetal, Germany
| | - Bo-Huei Huang
- Charles Perkins Centre, Faculty of Medicine and Health, School of Health Sciences, The University of Sydney, Sydney, NSW 2050, Australia
| | - Mark Hamer
- Division of Surgery and Interventional Science, Faculty of Medical Sciences, University College London, London WC1E 6BT, UK
| | - Annie Britton
- Institute of Epidemiology and Health Care, University College London, London WC1E 6BT, UK
| | - Emmanuel Stamatakis
- Charles Perkins Centre, Faculty of Medicine and Health, School of Health Sciences, The University of Sydney, Sydney, NSW 2050, Australia
| |
Collapse
|
13
|
Sex Differences in the Relationship between Excessive Alcohol Consumption and Metabolic Abnormalities: A Community-Based Study in Taiwan. Nutrients 2022; 14:nu14142957. [PMID: 35889913 PMCID: PMC9317740 DOI: 10.3390/nu14142957] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/03/2022] [Revised: 07/15/2022] [Accepted: 07/18/2022] [Indexed: 12/10/2022] Open
Abstract
Excessive alcohol consumption, as part of an unhealthy lifestyle, can contribute to metabolic abnormalities. This study investigated the sex differences in the relationship between excessive drinking and the risk of metabolic abnormalities. This community-based study included 3387 participants (age range: 30–103 years, mean age ± SD: 57 ± 13.5 years, 38.2% males) from the northeastern region of Taiwan. All participants completed a demographic survey and were subjected to blood tests. The risks of excessive drinking were evaluated using the Alcohol Use Disorder Identification Test (AUDIT). The results showed that males were at higher risks of obesity, hypertension, and hypertriglyceridemia, but at a lower risk of abdominal obesity than females. Males with hazardous drinking were at greater risks of hypertension, hyperglycemia, low serum levels of high-density lipoprotein cholesterol, and hypertriglyceridemia compared to those with no drinking. Females with hazardous drinking were at a greater risk of hypertension than those with no drinking. There was no interaction effect of sex and excessive drinking on the risks of metabolic abnormalities after controlling for demographics and lifestyle-related habits. Future studies are warranted to explore the sex-specific risk factors for metabolic abnormalities and to elucidate the mechanism underlying this association between alcohol consumption and metabolic abnormalities.
Collapse
|
14
|
The Profiling of Diet and Physical Activity in Reproductive Age Women and Their Association with Body Mass Index. Nutrients 2022; 14:nu14132607. [PMID: 35807789 PMCID: PMC9268133 DOI: 10.3390/nu14132607] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/26/2022] [Revised: 06/17/2022] [Accepted: 06/21/2022] [Indexed: 12/25/2022] Open
Abstract
Pre-pregnancy, pregnancy and postpartum are critical life stages associated with higher weight gain and obesity risk. Among these women, the sociodemographic groups at highest risk for suboptimal lifestyle behaviours and core lifestyle components associated with excess adiposity are unclear. This study sought to identify subgroups of women meeting diet/physical activity (PA) recommendations in relation to sociodemographics and assess diet/PA components associated with body mass index (BMI) across these life stages. Cross-sectional data (Australian National Nutrition and Physical Activity Survey 2011–2012) were analysed for pre-pregnancy, pregnant and postpartum women. The majority (63–95%) of women did not meet dietary or PA recommendations at all life stages. Core and discretionary food intake differed by sociodemographic factors. In pre-pregnant women, BMI was inversely associated with higher whole grain intake (β = −1.58, 95% CI −2.96, −0.21; p = 0.025) and energy from alcohol (β = −0.08, −0.14, −0.005; p = 0.035). In postpartum women, BMI was inversely associated with increased fibre (β = −0.06, 95% CI −0.11, −0.004; p = 0.034) and PA (β = −0.002, 95% CI −0.004, −0.001; p = 0.013). This highlights the need for targeting whole grains, fibre and PA to prevent obesity across life stages, addressing those most socioeconomically disadvantaged.
Collapse
|
15
|
Souza LPSE, Hermsdorff HHM, Miranda AEDS, Bressan J, Pimenta AM. Alcohol consumption and overweight in Brazilian adults - CUME Project. CIENCIA & SAUDE COLETIVA 2021; 26:4835-4848. [PMID: 34787179 DOI: 10.1590/1413-812320212611.3.20192019] [Citation(s) in RCA: 0] [Impact Index Per Article: 0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/04/2019] [Accepted: 10/25/2019] [Indexed: 11/22/2022] Open
Abstract
This is a cross-sectional study with 2,909 participants (aged ≥18 years) from the baseline of the Cohort of Universities of Minas Gerais [CUME - Coorte de Universidades Mineiras] which verified the association between alcohol consumption and overweight. Data on sociodemographic factors, lifestyle, eating habits, anthropometric factors and clinical conditions were collected through an online questionnaire. Body mass index ≥ 25 kg/m² was considered an indicator of overweight. The daily consumption of alcohol was evaluated in grams (alcohol) and according to type in milliliters (beer, wine, hard liquor). The prevalence of alcohol consumption and overweight was 73.6% and 40.8%, respectively. There was a significant tendency of an increase in overweight with higher beer consumption (tendency p value of 0.038), which was not observed for the other types of alcohol. After sensitivity analyses, alcohol consumption was associated to overweight, with a tendency of increase in prevalence with higher daily consumption. There is a crucial need to curb the widely accepted idea that a low or moderate alcohol consumption is not harmful to one's health, and to be cautious of such a proposition. The influence of alcohol consumption regarding weight gain must be considered in public health policies and policies of alcohol consumption control.
Collapse
Affiliation(s)
- Luís Paulo Souza E Souza
- Departamento de Medicina, Instituto de Saúde e Biotecnologia, Universidade Federal do Amazonas. Estrada Coari/Mamiá 305, Espírito Santo. 69.460-000 Coari AM Brasil
| | | | - Aline Elizabeth da Silva Miranda
- Programa de Pós-Graduação em Nutrição e Saúde, Escola de Enfermagem, Universidade Federal de Minas Gerais. Belo Horizonte MG Brasil
| | - Josefina Bressan
- Departamento de Nutrição e Saúde, Universidade Federal de Viçosa. Viçosa MG Brasil
| | - Adriano Marçal Pimenta
- Programa de Pós-Graduação em Nutrição e Saúde, Escola de Enfermagem, Universidade Federal de Minas Gerais. Belo Horizonte MG Brasil.,Departamento de Enfermagem Materno-Infantil e Saúde Pública, Escola de Enfermagem, Universidade Federal de Minas Gerais. Belo Horizonte MG Brasil.
| |
Collapse
|
16
|
Sun FR, Wang BY. Alcohol and Metabolic-associated Fatty Liver Disease. J Clin Transl Hepatol 2021; 9:719-730. [PMID: 34722187 PMCID: PMC8516839 DOI: 10.14218/jcth.2021.00173] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 05/10/2021] [Revised: 06/11/2021] [Accepted: 06/17/2021] [Indexed: 12/04/2022] Open
Abstract
The diagnosis of metabolic-associated fatty liver disease is based on the detection of liver steatosis together with the presence of metabolic dysfunction. According to this new definition, the diagnosis of metabolic-associated fatty liver disease is independent of the amount of alcohol consumed. Actually, alcohol and its metabolites have various effects on metabolic-associated abnormalities during the process of alcohol metabolism. Studies have shown improved metabolic function in light to moderate alcohol drinkers. There are several studies focusing on the role of light to moderate alcohol intake on metabolic dysfunction. However, the results from studies are diverse, and the conclusions are often controversial. This review systematically discusses the effects of alcohol consumption, focusing on light to moderate alcohol consumption, obesity, lipid and glucose metabolism, and blood pressure.
Collapse
Affiliation(s)
| | - Bing-Yuan Wang
- Correspondence to: Bing-Yuan Wang, Department of Elderly Gastroenterology, The First Hospital of China Medical University, Shenyang, Liaoning, China. ORCID: https://orcid.org/0000-0002-4233-6093. Tel: + 86-24-8328-3764, E-mail:
| |
Collapse
|
17
|
Heredia NI, Nguyen N, Martinez BA, Obasi EM, McNeill LH. The positive association between physical activity and alcohol use in African American adults. Prev Med Rep 2021; 23:101487. [PMID: 34381666 PMCID: PMC8333140 DOI: 10.1016/j.pmedr.2021.101487] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.3] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 02/03/2021] [Revised: 05/26/2021] [Accepted: 07/03/2021] [Indexed: 12/27/2022] Open
Abstract
African Americans have highest incidence and mortality from obesity-related cancers. Physical activity (PA), minimal alcohol use, and maintaining a low body mass index (BMI) are important cancer prevention behaviors, though there is little research on how these behaviors are associated with one another in African Americans. The purpose of this study is to assess the relationship between PA, alcohol use, and BMI using secondary data from an African American cohort recruited from Houston-area churches. Self-administered questionnaires measured self-reported PA, alcohol use, height, weight, and sociodemographic factors. Univariate and multivariable analyses assessed the relation between PA, alcohol use, BMI, controlling for covariates. Participants (N = 1009) were mostly female (77%), employed (72%), and college graduates (55%). Most (53%) reported both light-to-moderate alcohol use & moderate-to-high levels of PA. There was a statistically significant positive linear association between PA and alcohol use (Pearson's r = 0.15, p < 0.001). We also found that every one hour increase per week in PA was associated with 3% increased odds of being a heavy drinker (>2 drinks/day men, >1 drink/day women), as compared to an abstainer (Adjusted OR = 1.03, 95%CI 1.01-1.06). There was a statistically significant inverse association between PA and BMI, but no statistically significant association between alcohol use and BMI. In this sample of African Americans, PA and alcohol use were positively associated, mirroring results among Non-Hispanic Whites. However, alcohol use and BMI were not statistically significantly associated. Cancer and obesity prevention for African Americans should stress PA promotion while emphasizing messaging to curtail any associated increases in alcohol use.
Collapse
Affiliation(s)
- Natalia I. Heredia
- The University of Texas Health Science Center at Houston, School of Public Health, Houston, TX, United States
| | - Nga Nguyen
- The University of Texas MD Anderson Cancer Center, Houston, TX, United States
| | - Bryan A. Martinez
- The University of Texas Health Science Center at Houston, School of Public Health, Houston, TX, United States
| | - Ezemenari M. Obasi
- University of Houston, HEALTH Research Institute, Houston, TX, United States
| | - Lorna H. McNeill
- The University of Texas MD Anderson Cancer Center, Houston, TX, United States
| |
Collapse
|
18
|
Awoke MA, Skouteris H, Makama M, Harrison CL, Wycherley TP, Moran LJ. The Relationship of Diet and Physical Activity with Weight Gain and Weight Gain Prevention in Women of Reproductive Age. J Clin Med 2021; 10:2485. [PMID: 34199753 PMCID: PMC8199997 DOI: 10.3390/jcm10112485] [Citation(s) in RCA: 4] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/29/2021] [Revised: 06/01/2021] [Accepted: 06/01/2021] [Indexed: 11/16/2022] Open
Abstract
Reproductive-age women often see increased weight gain, which carries an increased risk of long-term overweight and obesity and adverse maternal and child health outcomes. Supporting women to achieve optimal weight through lifestyle modification (diet and physical activity) is of critical importance to reduce weight gain across key reproductive life-stages (preconception, pregnancy and postpartum). This review comprehensively summarizes the current state of knowledge on the contribution of diet and physical activity to weight gain and weight gain prevention in reproductive-aged women. Suboptimal diets including a higher proportion of discretionary choices or energy intake from fats, added sugars, sweets or processed foods are associated with higher weight gain, whereas increased consumption of core foods including fruits, vegetables and whole grains and engaging in regular physical activity are associated with reduced weight gain in reproductive age women. Diet and physical activity contributing to excessive gestational weight gain are well documented. However, there is limited research assessing diet and physical activity components associated with weight gain during the preconception and postpartum period. This review highlights the need for further research to identify key dietary and physical activity components targeting the critical windows of reproductive life-stages in women to best guide interventions to prevent weight gain.
Collapse
Affiliation(s)
- Mamaru Ayenew Awoke
- Monash Centre for Health Research and Implementation, Monash University, Clayton, VIC 3168, Australia; (M.A.A.); (M.M.); (C.L.H.)
| | - Helen Skouteris
- Health and Social Care Unit, School of Public Health and Preventive Medicine, Monash University, Melbourne, VIC 3004, Australia;
| | - Maureen Makama
- Monash Centre for Health Research and Implementation, Monash University, Clayton, VIC 3168, Australia; (M.A.A.); (M.M.); (C.L.H.)
| | - Cheryce L. Harrison
- Monash Centre for Health Research and Implementation, Monash University, Clayton, VIC 3168, Australia; (M.A.A.); (M.M.); (C.L.H.)
| | - Thomas Philip Wycherley
- Alliance for Research in Exercise, Nutrition and Activity, University of South Australia, Adelaide, SA 5001, Australia;
| | - Lisa J. Moran
- Monash Centre for Health Research and Implementation, Monash University, Clayton, VIC 3168, Australia; (M.A.A.); (M.M.); (C.L.H.)
| |
Collapse
|
19
|
Golzarand M, Salari-Moghaddam A, Mirmiran P. Association between alcohol intake and overweight and obesity: a systematic review and dose-response meta-analysis of 127 observational studies. Crit Rev Food Sci Nutr 2021; 62:8078-8098. [PMID: 33998940 DOI: 10.1080/10408398.2021.1925221] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/21/2022]
Abstract
Several studies have assessed the relationship between alcohol intake and overweight/obesity; however, the reported results are inconsistent. Therefore, the present systematic review and dose-response meta-analysis of observational studies was designed to investigate the association between alcohol intake and general and abdominal obesity among the adults. Literature search was conducted in the PubMed/Medline and Web of Science databases up to August 2020. Odds ratio (OR), risk ratio (RR), or hazard ratio (HR) with 95% confidence interval (95% CI) were used to pool effect size. To conduct dose-response meta-analysis, amount of alcohol intake was classified into three categories including light (<14 g/d), moderate (14-28 g/d), and heavy (>28 g/d). In the present study, 127 eligible studies were included. In cohort studies, there was no significant association between alcohol drinking and risk of overweight (OR: 0.93, 95% CI: 0.46 to 1.89), obesity (OR: 0.84, 95% CI: 0.52 to 1.37), overweight/obesity (OR: 1.15, 95% CI: 0.84 to 1.58), and abdominal obesity (OR: 1.13, 95% CI: 0.90 to 1.41). In cross-sectional studies, alcohol intake was associated with the increased odds of overweight (OR: 1.11, 95% CI: 1.05 to 1.18), overweight/obesity (OR: 1.23, 95% CI: 1.11 to 1.37), and abdominal obesity (OR: 1.19, 95% CI: 1.09 to 1.29); but not obesity (OR: 1.03, 95% CI: 0.95 to 1.12). Results of dose-response analysis indicated that heavy alcohol drinking was positively associated with odds of overweight (OR: 1.12, 95% CI: 1.01 to 1.24), overweight/obesity (OR: 1.32, 95% CI: 1.16 to 1.51), and abdominal obesity (OR: 1.25, 95% CI: 1.12 to 1.38) compared to non- or light alcohol drinking. There was no publication bias among studied on outcomes of interest. In conclusion, our results revealed alcohol drinkers, especially heavy alcohol drinkers, had increased odds of overweight, overweight/obesity, and abdominal obesity than non-alcohol drinker or light alcohol drinkers among cross-sectional studies but not cohort studies.
Collapse
Affiliation(s)
- Mahdieh Golzarand
- Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| | - Asma Salari-Moghaddam
- Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran
| | - Parvin Mirmiran
- Nutrition and Endocrine Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.,Department of Clinical Nutrition and Dietetics, Faculty of Nutrition Sciences and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| |
Collapse
|
20
|
To K, Mak C, Zhang C, Zhou Y, Filbay S, Khan W. The association between alcohol consumption and osteoarthritis: a meta-analysis and meta-regression of observational studies. Rheumatol Int 2021; 41:1577-1591. [PMID: 33745000 PMCID: PMC8316228 DOI: 10.1007/s00296-021-04844-0] [Citation(s) in RCA: 8] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/17/2021] [Accepted: 03/11/2021] [Indexed: 01/07/2023]
Abstract
There is conflicting evidence for the association between alcohol consumption and common joint conditions such as Osteoarthritis (OA), which affects millions of people. We sought to determine the true association between alcohol intake and OA. We conducted a PRISMA systematic review and meta-analysis of observational studies that reported associations between alcohol consumption and OA. Pooled estimates of association were represented through odds ratios (ORs). Publication bias was assessed with Funnel and Galbraith plots, and risk of bias was assessed with the Newcastle Ottawa Scale. We included 29 studies and 25,192 subjects with OA and reported an OR between any alcohol consumption and OA of 0.79 (0.68–0.93), suggesting a protective effect. OR of weekly or more frequent use was 0.79 (0.65–0.97). When grouped by covariates, alcohol consumption was negatively associated with radiographic (0.83, 0.70–0.98), hand (0.80, 0.66–0.95) and knee OA (0.85, 0.72–0.99), North American ethnicity and female gender. Subgroup analysis of unadjusted data resulted in an OR of 0.70 (0.55–0.89) but this disappeared upon analysis of studies with data adjusted for any covariate (0.93, 0.78–1.10). Whilst our pooled analysis suggest that weekly or more frequent alcohol consumption was negatively associated with OA, this was not observed when adjusted for confounding factors. Reasons for this include selection bias and lack of longitudinal exposure and adjustment for confounding variables. Therefore, this meta-analysis provides evidence to dispel notions that alcohol use may be protective against OA.
Collapse
Affiliation(s)
- Kendrick To
- Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Cambridge, CB2 0QQ, UK
| | - Christopher Mak
- School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK
| | - Chen Zhang
- School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK
| | - Yuhui Zhou
- School of Clinical Medicine, University of Cambridge, Cambridge, CB2 0QQ, UK
| | - Stephanie Filbay
- Department of Physiotherapy, Centre for Health Exercise and Sports Medicine, University of Melbourne, Melbourne, VIC, 3010, Australia.,Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Oxford, OX3 7LD, UK
| | - Wasim Khan
- Division of Trauma and Orthopaedic Surgery, Department of Surgery, University of Cambridge, Cambridge, CB2 0QQ, UK.
| |
Collapse
|
21
|
Association of Alcohol Use and Physical Activity with Body Mass Index in Mexican-Origin Adults. J Racial Ethn Health Disparities 2021; 9:812-819. [PMID: 33721292 DOI: 10.1007/s40615-021-01019-2] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 10/13/2020] [Revised: 02/10/2021] [Accepted: 03/03/2021] [Indexed: 10/21/2022]
Abstract
BACKGROUND Studies across racial/ethnic groups indicate that physical activity (PA) and alcohol consumption are positively associated, and that alcohol consumption is negatively associated with body mass index (BMI), but this relationship is less often evaluated in Hispanics. The purpose of this study was to assess the relationships between alcohol consumption, PA, and BMI in Hispanic adults. METHODS In this secondary data analysis of a Mexican-American cohort, we collected self-reported PA, alcohol consumption, and demographics, and measured height and weight. Linear regression assessed the association between PA and alcohol consumption with BMI, controlling for covariates. Total sample for analyses was n = 3897. RESULTS We found an inverse relationship between high PA and BMI in the full sample (adjusted estimate = - 0.03, 95% CI - 0.07, - 0.01) and in females, but not males. We also found an inverse relationship between current alcohol use and BMI in the full sample (adjusted estimate = - 0.05, 95% CI - 0.09, - 0.01) and both sexes. There was no significant interaction between PA and alcohol use on BMI. CONCLUSIONS In this study of Mexican-origin adults, current alcohol use and high PA were associated with lower BMIs, but there was no interaction between PA and alcohol use. These results can be used to inform multiple behavior change interventions in Mexican-origin adults.
Collapse
|
22
|
Pan D, Wang S, Su M, Wei J, Wang K, Luo P, Smith JD, Ma G, Sun G. Roles of drinking and diet in the U-shaped relationship between smoking and BMI in middle-aged and elderly Chinese rural adults. Sci Rep 2020; 10:17118. [PMID: 33051586 PMCID: PMC7555487 DOI: 10.1038/s41598-020-74414-0] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/19/2020] [Accepted: 09/28/2020] [Indexed: 11/08/2022] Open
Abstract
The study aimed to investigate the relationship between smoking and BMI, from the perspective of the roles of alcohol drinking and dietary factors in a rural population. We analysed cross-sectional data from 10,837 middle-aged and elderly Chinese rural adults who completed a questionnaire that included questions on demographic characteristics, dietary intake, and detailed smoking and drinking status. Results showed that current smokers had lower BMI and consumed foods less frequently (except coriander, onion, garlic, hawthorn and fermented bean curd) than non-smokers. The relationship between smoking amount and the risk of overweight or obesity was U-shaped, and the trends were also similar by stratum of baseline age groups (all p for interaction < 0.001). Heavy smokers tended to have drinking habits, which was associated with increased BMI (all p for trend < 0.001). Additionally, despite the lower risk of overweight or obesity for current smokers, normal weight individuals were found to have the minimum smoking amount. In conclusion, smoking may cause suppression of appetite but smokers tend to have other unhealthy habits relating to increased BMI. Dietary factors and alcohol use play important roles in the U-shaped relationship between smoking behaviours and BMI in the middle-aged and elderly Chinese rural population.
Collapse
Affiliation(s)
- Da Pan
- Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, People's Republic of China
| | - Shaokang Wang
- Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, People's Republic of China
| | - Ming Su
- Huai'an District Center for Disease Control and Prevention, Huai'an, People's Republic of China
| | - Jie Wei
- Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, People's Republic of China
| | - Kai Wang
- Huai'an District Center for Disease Control and Prevention, Huai'an, People's Republic of China
| | - Pengfei Luo
- Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, 210009, People's Republic of China
| | | | - Gege Ma
- Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, People's Republic of China
| | - Guiju Sun
- Key Laboratory of Environmental Medicine and Engineering of Ministry of Education, and Department of Nutrition and Food Hygiene, School of Public Health, Southeast University, Nanjing, 210009, People's Republic of China.
| |
Collapse
|
23
|
Inan-Eroglu E, Powell L, Hamer M, O’Donovan G, Duncan MJ, Stamatakis E. Is There a Link between Different Types of Alcoholic Drinks and Obesity? An Analysis of 280,183 UK Biobank Participants. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2020; 17:ijerph17145178. [PMID: 32709071 PMCID: PMC7400254 DOI: 10.3390/ijerph17145178] [Citation(s) in RCA: 10] [Impact Index Per Article: 2.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 05/29/2020] [Revised: 07/11/2020] [Accepted: 07/13/2020] [Indexed: 02/06/2023]
Abstract
Understanding the associations between types of alcoholic drinks and adiposity has public health relevance, considering that adult overweight and obesity prevalence are increasing worldwide. We aimed to evaluate the association between overall alcohol consumption and types of alcohol drinks with markers of adiposity from the UK Biobank baseline data (n = 280,183, 48.3% female). Generalized linear models were used to examine the associations between alcohol consumption with body mass index (BMI) and body fat percentage. Those drinking within the public health guidelines had a lower BMI by 1.34 kg/m2 (95% CI 1.42, 1.26 kg/m2) compared to never drinkers. Association between alcohol consumption and body fat percentage were not statistically significant. Compared to those who never drink wines (red wine, champagne and fortified wine), drinkers of these alcoholic beverages had lower BMI (difference of -0.75 kg/m2, 95% CI -0.78, -0.72 kg/m2; -0.48 kg/m2, 95% CI -0.52, -0.45 kg/m2; and -0.24 kg/m2, 95% CI -0.29, -0.18 kg/m2, respectively). Beer and spirits drinkers had higher BMI compared to never drinkers of beer and spirits (difference of 0.18 kg/m2, 95% CI 0.14, 0.22 kg/m2 and 0.64 kg/m2, 95% CI 0.61, 0.68 kg/m2, respectively). Our data did not find a link between alcohol drinking and higher risk of obesity.
Collapse
Affiliation(s)
- Elif Inan-Eroglu
- The Boden Collaboration for Obesity, Nutrition, Exercise & Eating Disorders, Faculty of Medicine and Health, The University of Sydney, Sydney NSW 2050, Australia;
- Prevention Research Collaboration, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney NSW 2050, Australia;
| | - Lauren Powell
- Prevention Research Collaboration, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney NSW 2050, Australia;
| | - Mark Hamer
- Faculty of Medical Sciences, University College London, London WC1E 6BT, UK;
| | - Gary O’Donovan
- Facultad de Medicina, Universidad de los Andes, Bogotá 57, Colombia;
| | - Mitch J. Duncan
- School of Medicine & Public Health; Faculty of Health and Medicine, The University of Newcastle, University Drive, Callaghan NSW 2308, Australia;
- Priority Research Centre for Physical Activity and Nutrition, The University of Newcastle, University Drive, Callaghan NSW 2308, Australia
| | - Emmanuel Stamatakis
- Prevention Research Collaboration, School of Public Health, Faculty of Medicine and Health, The University of Sydney, Sydney NSW 2050, Australia;
- Charles Perkins Centre Epidemiology Unit, The University of Sydney, Sydney NSW 2050, Australia
- Correspondence: ; Tel.: +61-2-86271867
| |
Collapse
|
24
|
Diao Y, Nie J, Tan P, Zhao Y, Zhao T, Tu J, Ji H, Cao Y, Wu Z, Liang H, Huang H, Li Y, Gao X, Zhou L. Long-term low-dose ethanol intake improves healthspan and resists high-fat diet-induced obesity in mice. Aging (Albany NY) 2020; 12:13128-13146. [PMID: 32639947 PMCID: PMC7377878 DOI: 10.18632/aging.103401] [Citation(s) in RCA: 7] [Impact Index Per Article: 1.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/18/2020] [Accepted: 05/01/2020] [Indexed: 12/26/2022]
Abstract
Numerous epidemiological studies have reported that moderate alcohol drinking has beneficial effects. However, few studies have focused on the beneficial effects of ethanol, the common component in alcoholic beverages. Here we fed the C57BL/6 mice with 3.5% v/v ethanol as drinking water substitute to investigate the effects of long-term low-dose ethanol intake in vivo. We evaluated the metabolic rate and mitochondrial function of the long-term low-dose ethanol-intake (LLE) mice, assessed the exercise ability of LLE mice, and fed the LLE mice with a high-fat diet to investigate the potential impact of ethanol on it. The LLE mice showed improved thermogenic activity, physical performance, and mitochondrial function, as well as resistance against the high-fat diet-induced obesity with elevated insulin sensitivity and subdued inflammation. Our results suggest that long-term low-dose ethanol intake can improve healthspan and resist high-fat diet-induced obesity in mice. It may provide new insight into understanding the protective effects of moderate alcohol drinking.
Collapse
Affiliation(s)
- Yan Diao
- Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.,Department of Clinical Laboratory, Heilongjiang Province Hospital, Harbin, China
| | - Junhui Nie
- Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.,Translational Medicine Center of Northern China, Harbin, China
| | - Peizhu Tan
- Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.,Translational Medicine Center of Northern China, Harbin, China.,Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, Ministry of Education, China
| | - Yuchen Zhao
- Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.,Translational Medicine Center of Northern China, Harbin, China
| | - Tingting Zhao
- Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.,Translational Medicine Center of Northern China, Harbin, China
| | - Jiajie Tu
- Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.,Translational Medicine Center of Northern China, Harbin, China
| | - Heng Ji
- Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.,Translational Medicine Center of Northern China, Harbin, China
| | - Yuwei Cao
- Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.,Translational Medicine Center of Northern China, Harbin, China
| | - Zhaojing Wu
- Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.,Translational Medicine Center of Northern China, Harbin, China
| | - Huan Liang
- Department of Clinical Laboratory, Harbin Medical University Cancer Hospital, Harbin, China
| | - Hui Huang
- Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.,Translational Medicine Center of Northern China, Harbin, China
| | - Yanze Li
- Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.,Translational Medicine Center of Northern China, Harbin, China
| | - Xu Gao
- Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.,Translational Medicine Center of Northern China, Harbin, China.,Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, Ministry of Education, China
| | - Lingyun Zhou
- Department of Biochemistry and Molecular Biology, Harbin Medical University, Harbin, China.,Translational Medicine Center of Northern China, Harbin, China.,Key Laboratory of Preservation of Human Genetic Resources and Disease Control in China, Ministry of Education, China
| |
Collapse
|
25
|
Song M, Nam S, Buss J, Lee SJ. Assessing the prevalence of meeting physical activity recommendations among U.S. healthcare workers: Data from the 2015 National Health Interview Survey. ARCHIVES OF ENVIRONMENTAL & OCCUPATIONAL HEALTH 2020; 75:422-430. [PMID: 32202219 PMCID: PMC9301781 DOI: 10.1080/19338244.2020.1743960] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Subscribe] [Scholar Register] [Indexed: 06/10/2023]
Abstract
We examined the prevalence of U.S. healthcare workers who met the 2008 Physical Activity Guidelines for Americans (2008 Guidelines), and the relationships among meeting the 2008 Guidelines and health behaviors, musculoskeletal symptoms, and occupational- and workplace- factors. We estimated prevalence of meeting the 2008 Guidelines for aerobic and muscle-strengthening activity using data from the 2015 National Health Interview Survey. Among 1,502 U.S. healthcare workers, 56.2% met the recommended guideline for aerobic activity; 30.1% met the recommended guideline for muscle-strengthening activity; and 25.3% met both recommended guidelines. Adjusting for covariates, meeting the 2008 Guidelines was associated with no history of smoking, current alcohol consumption, type of occupation, occupational activities, and availability of a health promotion program at work. Our findings suggest multi-level approaches (combining individual and organizational level efforts) are needed.
Collapse
Affiliation(s)
- MinKyoung Song
- School of Nursing, Oregon Health & Science University, Portland, Oregon, United States
| | - Soohyun Nam
- School of Nursing, Yale University, Orange, CT, United States
| | - Julia Buss
- School of Nursing, UCSF, San Francisco, CA, United States
| | - Soo-Jeong Lee
- School of Nursing, UCSF, San Francisco, CA, United States
| |
Collapse
|
26
|
Ranabhat CL, Park MB, Kim CB. Influence of Alcohol and Red Meat Consumption on Life Expectancy: Results of 164 Countries from 1992 to 2013. Nutrients 2020; 12:nu12020459. [PMID: 32059386 PMCID: PMC7071474 DOI: 10.3390/nu12020459] [Citation(s) in RCA: 14] [Impact Index Per Article: 2.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/02/2020] [Revised: 02/04/2020] [Accepted: 02/07/2020] [Indexed: 12/20/2022] Open
Abstract
Background: High consumption of red meat, which is carcinogenic to humans, and misuse or abuse of alcohol drinking increase premature death and shortened life expectancy. The aim of this study was to examine the association of alcohol and red meat consumption with life expectancy (LE) by analyzing data from 164 countries using an ecological approach. Design: This was a longitudinal ecological study using data from the United Nation’s (UN) Food and Agriculture Organization (FAO) for 164 countries over the period 1992–2013. In regression analysis, the relationship of alcohol and red meat consumption with LE was estimated using a pooled ordinary least squares regression model. Alcohol and red meat consumption were measured every 5 years. Results: The consumption of alcohol and red meat in high-income countries (HIC) was about 4 times (36.8–143.0 kcal/capita/day) and 5 times (11.2–51.9 kcal/capita/day) higher than that in low-income countries (LIC). Red meat and alcohol consumption had a negative estimated effect on LE in HIC (b = −1.616 p = < 0.001 and b = −0.615, p = 0.003). Alcohol consumption was negatively associated with LE for all income groups, while positive relationships were found for all estimates associated with gross national income (GNI). Conclusions: Red meat and alcohol consumption appeared to have a negative impact on LE in high-income countries (HIC) and upper-middle-income countries (UMIC), although it had no significant association with LE in low-income countries (LIC) or lower-middle-income countries (LMIC). This study suggests reviewing the policies on the gradual reduction of alcohol abuse and the high consumption of red meat, particularly HIC and UMIC.
Collapse
Affiliation(s)
- Chhabi Lal Ranabhat
- Department of Gerontology Health and Welfare, Pai Chai University, Seo-gu, Daejeon 35345, Korea
- Policy Research Institute, Sanogaucharan 44600, Kathmandu, Nepal
- Global Centre for Research and Development (GCRD), Kathmandu 44600, Nepal
- Correspondence: (C.L.R.); (M.-B.P.); (C.-B.K.)
| | - Myung-Bae Park
- Department of Gerontology Health and Welfare, Pai Chai University, Seo-gu, Daejeon 35345, Korea
- Correspondence: (C.L.R.); (M.-B.P.); (C.-B.K.)
| | - Chun-Bae Kim
- Institute for Poverty Alleviation and International Development, Yonsei University, 1 Yonseidae-Gil, Wonju-City 26493, Gangwon-Do, Korea
- Department of Preventive Medicine, Yonsei University Wonju College of Medicine, 20 Ilsan-ro Wonju-City 26426, Gandwon-do, Korea
- Hongcheon-County Hypertension and Diabetes Registration and Education Center, 5 Sinjangdae-ro Hongcheon-Gun 25135, Gandwon-do, Korea
- Correspondence: (C.L.R.); (M.-B.P.); (C.-B.K.)
| |
Collapse
|
27
|
Molina-Hidalgo C, De-la-O A, Jurado-Fasoli L, Amaro-Gahete FJ, Castillo MJ. Beer or Ethanol Effects on the Body Composition Response to High-Intensity Interval Training. The BEER-HIIT Study. Nutrients 2019; 11:E909. [PMID: 31018614 PMCID: PMC6521009 DOI: 10.3390/nu11040909] [Citation(s) in RCA: 6] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/25/2019] [Revised: 04/16/2019] [Accepted: 04/18/2019] [Indexed: 11/16/2022] Open
Abstract
High-intensity interval training (HIIT) is promoted as a time-efficient strategy to improve body composition but concomitant beer intake, which is common among physically active individuals, may interfere with these effects. The primary aim of this study is to determine the effects of a 10-week (2 days/week) HIIT program on anthropometric and body composition measurements, and to assess whether those effects are influenced by the moderate consumption of beer (at least 5 days/week), or its alcohol equivalent. Young (24 ± 6 years old) healthy adults (n = 72, 35 females) volunteered for a non-training group (Non-Training group) or for HIIT training. Those going for training choose whether they preferred to receive alcohol or not. Those choosing alcohol were randomly allocated for receiving beer (5.4%; T-Beer group) or the equivalent amount of alcohol (vodka; T-Ethanol group) in sparkling water. Those choosing no-alcohol were randomly allocated for receiving alcohol-free beer (0.0%; T-0.0Beer group) or sparkling water (T-Water group). From Monday through Friday, men ingested 330 mL of the beverage with lunch and 330 mL with dinner; women ingested 330 mL with dinner. Before and after the intervention, anthropometry and body composition, through dual-emission X-ray absorptiometry, were measured. No changes in body mass, waist circumference, waist/hip ratio, visceral adipose tissue or bone mineral density occurred in any of the groups. By contrast, in all the training groups, significant decreases in fat mass together with increases in lean mass (all p < 0.05) occurred. These positive effects were not influenced by the regular intake of beer or alcohol. In conclusion, a moderate beer intake does not blunt the positive effect of 10-week HIIT on body composition in young healthy adults.
Collapse
Affiliation(s)
- Cristina Molina-Hidalgo
- EFFECTS 262 Department of Medical Physiology. School of Medicine. University of Granada. 18071 Granada, Spain.
| | - Alejandro De-la-O
- EFFECTS 262 Department of Medical Physiology. School of Medicine. University of Granada. 18071 Granada, Spain.
| | - Lucas Jurado-Fasoli
- EFFECTS 262 Department of Medical Physiology. School of Medicine. University of Granada. 18071 Granada, Spain.
| | - Francisco J Amaro-Gahete
- EFFECTS 262 Department of Medical Physiology. School of Medicine. University of Granada. 18071 Granada, Spain.
| | - Manuel J Castillo
- EFFECTS 262 Department of Medical Physiology. School of Medicine. University of Granada. 18071 Granada, Spain.
| |
Collapse
|
28
|
Fazzino TL, Forbush K, Sullivan D, Befort CA. A Prospective Study of Alcohol Use Patterns and Short-Term Weight Change in College Freshmen. Alcohol Clin Exp Res 2019; 43:1016-1026. [PMID: 30889279 DOI: 10.1111/acer.14025] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.7] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 11/28/2018] [Accepted: 03/11/2019] [Indexed: 12/29/2022]
Abstract
BACKGROUND The transition to college is a developmentally sensitive time in which freshmen are at high risk for engaging in heavy drinking and experiencing changes in weight and body composition. The study tested prospective associations among drinking patterns (weekly drinks, heavy drinking occasions/month) and alcohol calorie intake on weight and waist circumference change over the first year of college. METHODS College freshmen (N = 103) were randomly selected from a pool of eligible students to participate at the beginning of the academic year. The sample was comprised of 52% males, 46% of individuals identifying as racial or ethnic minority, and 45% students with at-risk drinking as defined by the Alcohol Use Disorders Identification Test-Consumption questions. Students engaging in daily risky drinking (n = 2) were excluded. Participants attended 3 visits during the academic year during which they provided weight and waist circumference measurements and completed assessments about drinking, dietary intake, and physical activity. RESULTS Weight gain (>2.3 kg) occurred in 28% of participants. In linear mixed models, drinking patterns and alcohol calorie intake were not associated with weight or waist circumference changes within individuals, when controlling for demographic and energy balance variables. Drinking patterns and alcohol calorie intake did not account for differences in anthropometric measurements between participants, when controlling for covariates. CONCLUSIONS Alcohol use did not explain the anthropometric changes observed in a sample well represented by freshmen engaging in risky drinking (and excluding those with daily risky drinking) during the academic year. Drinking may not contribute to short-term weight gain among freshmen.
Collapse
Affiliation(s)
- Tera L Fazzino
- Department of Preventive Medicine and Public Health , University of Kansas Medical Center, Kansas City, Kansas
| | - Kelsie Forbush
- Department of Psychology , University of Kansas, Lawrence, Kansas
| | - Debra Sullivan
- Department of Nutrition and Dietetics , University of Kansas Medical Center, Kansas City, Kansas
| | - Christie A Befort
- Department of Preventive Medicine and Public Health , University of Kansas Medical Center, Kansas City, Kansas
| |
Collapse
|
29
|
Sumi M, Hisamatsu T, Fujiyoshi A, Kadota A, Miyagawa N, Kondo K, Kadowaki S, Suzuki S, Torii S, Zaid M, Sato A, Arima H, Terada T, Miura K, Ueshima H. Association of Alcohol Consumption With Fat Deposition in a Community-Based Sample of Japanese Men: The Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA). J Epidemiol 2018; 29:205-212. [PMID: 29848904 PMCID: PMC6522392 DOI: 10.2188/jea.je20170191] [Citation(s) in RCA: 6] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/25/2023] Open
Abstract
Background Excessive alcohol intake has been shown to be associated with cardiovascular disease via metabolic pathways. However, the relationship between alcohol intake and obesity has not been fully elucidated. We aimed to examine the association of alcohol consumption with fat deposition and anthropometric measures. Methods From 2006–2008, we conducted a cross-sectional study in a population-based sample of Japanese men aged 40 through 79 years. Areas of abdominal visceral adipose tissue (VAT) and subcutaneous adipose tissue (SAT) were calculated using computed tomography imaging. Based on a questionnaire, we classified participants into five groups according to weekly alcohol consumption, excluding former drinkers: non-drinkers (0 g/week), 0.1–160.9, 161–321.9, 322–482.9, and ≥483 g/week. Multivariable linear regression was used to estimate adjusted means of obesity indices for each group. Results We analyzed 998 men (mean age and body mass index [BMI], 63.8 years and 23.6 kg/m2, respectively). Higher weekly alcohol consumption was strongly and significantly associated with higher abdominal VAT area, percentage of VAT, and VAT-to-SAT ratio (all P for trend <0.001), and also with waist circumferences and waist-to-hip ratio (P for trend = 0.042 and 0.007, respectively). These associations remained significant after further adjustment for BMI, whereas alcohol consumption had no significant association with abdominal SAT area. Conclusions Higher alcohol consumption was associated with higher VAT area, VAT%, and VAT-to-SAT ratio, independent of confounders, including BMI, in general Japanese men. These results suggest that alcohol consumption may have a potential adverse effect on visceral fat deposition.
Collapse
Affiliation(s)
- Masaki Sumi
- Department of Public Health, Shiga University of Medical Science.,Department of Pharmacy, Shiga University of Medical Science Hospital
| | - Takashi Hisamatsu
- Department of Public Health, Shiga University of Medical Science.,Department of Environmental Medicine and Public Health, Faculty of Medicine, Shimane University
| | - Akira Fujiyoshi
- Department of Public Health, Shiga University of Medical Science
| | - Aya Kadota
- Center for Epidemiologic Research in Asia, Shiga University of Medical Science
| | - Naoko Miyagawa
- Department of Public Health, Shiga University of Medical Science
| | - Keiko Kondo
- Department of Public Health, Shiga University of Medical Science
| | - Sayaka Kadowaki
- Department of Public Health, Shiga University of Medical Science
| | - Sentaro Suzuki
- Department of Public Health, Shiga University of Medical Science
| | - Sayuki Torii
- Department of Public Health, Shiga University of Medical Science
| | - Maryam Zaid
- Center for Epidemiologic Research in Asia, Shiga University of Medical Science
| | - Atsushi Sato
- Department of Public Health, Shiga University of Medical Science
| | - Hisatomi Arima
- Department of Preventive Medicine and Public Health, Faculty of Medicine, Fukuoka University
| | - Tomohiro Terada
- Department of Pharmacy, Shiga University of Medical Science Hospital
| | - Katsuyuki Miura
- Department of Public Health, Shiga University of Medical Science.,Center for Epidemiologic Research in Asia, Shiga University of Medical Science
| | - Hirotsugu Ueshima
- Department of Public Health, Shiga University of Medical Science.,Center for Epidemiologic Research in Asia, Shiga University of Medical Science
| |
Collapse
|
30
|
Pereira JL, Félix PV, Mattei J, Fisberg RM. Differences over 12 Years in Food Portion Size and Association with Excess Body Weight in the City of São Paulo, Brazil. Nutrients 2018; 10:E696. [PMID: 29848971 PMCID: PMC6024366 DOI: 10.3390/nu10060696] [Citation(s) in RCA: 11] [Impact Index Per Article: 1.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/02/2018] [Revised: 05/24/2018] [Accepted: 05/28/2018] [Indexed: 12/21/2022] Open
Abstract
Although changes in Brazilian diet have occurred over the last decades, there is no evidence about differences in food portion sizes (FPS) over time. Therefore, we aimed to evaluate the association of FPS with excess body weight (EBW), and to monitor differences in the population from São Paulo, Brazil, from 2003 to 2015. Data came from three cross-sectional population-based studies with 5270 individuals aged ≥12 years in 2003, 2008, and 2015. Dietary data were obtained from 24-h recalls. Logistic regression models were used to evaluate the association between FPS and EBW. Over the years, there was a diverse variation in FPS, with an increase in some groups (white meat, salted snacks, coffee/tea, eggs) and decrease in others (rice, red meat, sweets, pasta, sandwiches, cold cuts). The percentage of people reporting the intake of six food groupings (rice, white meat, sweets, fruits, commercial juices, toasts/biscuits) increased in the period. In this population, EBW was associated with larger FPS of 11 of the 30 food groupings investigated (cold cuts, fried snacks, fruit and commercial juices, pizza, red meat, rice, salted snacks, soft drinks, soups, sugar). These findings could support future interventions and policies for optimal food intake in Brazil.
Collapse
Affiliation(s)
- Jaqueline Lopes Pereira
- Department of Nutrition, School of Public Health, University of São Paulo, São Paulo SP 01246-904, Brazil.
| | - Paula Victória Félix
- Department of Nutrition, School of Public Health, University of São Paulo, São Paulo SP 01246-904, Brazil.
| | - Josiemer Mattei
- Department of Nutrition, Harvard T. H. Chan School of Public Health, Boston, MA 02115, USA.
| | - Regina Mara Fisberg
- Department of Nutrition, School of Public Health, University of São Paulo, São Paulo SP 01246-904, Brazil.
| |
Collapse
|
31
|
Xie J, Tian XF, He SG, Wei YL, Peng B, Wu ZQ. Evaluating the Intoxicating Degree of Liquor Products with Combinations of Fusel Alcohols, Acids, and Esters. Molecules 2018; 23:E1239. [PMID: 29789494 PMCID: PMC6100290 DOI: 10.3390/molecules23061239] [Citation(s) in RCA: 8] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/19/2018] [Revised: 05/17/2018] [Accepted: 05/20/2018] [Indexed: 11/16/2022] Open
Abstract
To investigate the effects of fusel alcohols on the intoxicating degree of liquor products, formulated liquors (FLs) were prepared by blending 1-propanol, isobutanol, and isoamyl alcohol with ethanol, organic acids, and corresponding ethyl esters to simulate the formula of traditional Chinese liquors. The prepared FLs were submitted for evaluation of their intoxicating degree (ID). The results showed that the fusel alcohols had a biphasic effect on the IDs of the FLs, depending on the comprehensive coordination of the characteristic minor components. The importance of the suitable ratio of alcohols/acids/esters (RAAE) on the IDs was also revealed. Under an optimal ratio level, the fusel alcohols exhibited negligible effects on the IDs of the FLs. Moreover, the ratio of isoamyl alcohol to isobutanol (IA/IB) showed a strong positive correlation to the IDs of the FLs. This study lays a foundation for the potential application in producing low-ID liquor.
Collapse
Affiliation(s)
- Jia Xie
- School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, Guangdong, China.
| | - Xiao-Fei Tian
- School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, Guangdong, China.
| | - Song-Gui He
- Guangdong Jiujiang Distillery Co., Ltd., Foshan 528203, Guangdong, China.
| | - Yun-Lu Wei
- Guangdong Jiujiang Distillery Co., Ltd., Foshan 528203, Guangdong, China.
| | - Bin Peng
- School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, Guangdong, China.
| | - Zhen-Qiang Wu
- School of Biology and Biological Engineering, South China University of Technology, Guangzhou 510006, Guangdong, China.
| |
Collapse
|
32
|
Roos E, Lallukka T, Lahelma E, Rahkonen O. The joint associations of smoking and obesity with subsequent short and long sickness absence: a five year follow-up study with register-linkage. BMC Public Health 2017; 17:978. [PMID: 29282110 PMCID: PMC5745910 DOI: 10.1186/s12889-017-4997-x] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 03/30/2017] [Accepted: 12/14/2017] [Indexed: 11/25/2022] Open
Abstract
Background Both smoking and obesity are separately associated with sickness absence. Unhealthy lifestyle habits and health conditions may occur concurrently yet studies focusing on their joint association are few. This study examined the joint associations of smoking and obesity with sickness absence (SA). Methods A mail survey among employees of the City of Helsinki, Finland, during 2000–2002 included data on obesity, smoking and covariates (N = 8960, response rate 67%, 80% women). These data were prospectively linked with register data on self- (1–3 days) and medically certified (4 days or longer) SA among those consenting to the linkage (n = 6986). Pregnant, underweight and those with missing data on key variables were excluded (n = 138). The total number of participants included in the analyses was 6847. The follow-up time was 5 years. Poisson regression was used to calculate rate ratios (RR). Results Among women and men smoking and obesity were associated with self-certified SA. Among women there was a joint association with self-certified SA (obese smokers RR 1.81, 95% CI 1.59–2.07). Among women and men smoking and obesity were jointly associated with medically certified SA (for obese smoking women RR 2.23, 95% CI 1.93–2.57, for obese smoking men RR 2.69, 95% CI 2.03–3.55). Associations remained after adjustments for socioeconomic position, working conditions, health behaviours and self-rated health. Conclusion Both smoking and obesity are jointly associated with all lengths of sickness absence. Support measures for smoking cessation and prevention of obesity could likely to reduce SA.
Collapse
Affiliation(s)
- Eira Roos
- Department of Public Health, University of Helsinki, Post Box 20, 00014, Helsinki, Finland.
| | - Tea Lallukka
- Department of Public Health, University of Helsinki, Post Box 20, 00014, Helsinki, Finland.,Finnish Institute of Occupational Health, Helsinki, Finland
| | - Eero Lahelma
- Department of Public Health, University of Helsinki, Post Box 20, 00014, Helsinki, Finland
| | - Ossi Rahkonen
- Department of Public Health, University of Helsinki, Post Box 20, 00014, Helsinki, Finland
| |
Collapse
|
33
|
Effects of White Wine Consumption on Weight in Rats: Do Polyphenols Matter? OXIDATIVE MEDICINE AND CELLULAR LONGEVITY 2017; 2017:8315803. [PMID: 29225724 PMCID: PMC5684572 DOI: 10.1155/2017/8315803] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.9] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Subscribe] [Scholar Register] [Received: 04/06/2017] [Revised: 08/10/2017] [Accepted: 09/25/2017] [Indexed: 11/30/2022]
Abstract
Introduction Effects of white wine and the role of wine polyphenols on weight gain in rats of different age were examined in the 4-week-voluntary-consumption trial. Methods and Materials Biochemically characterized standard (low polyphenols, W) and macerated (high polyphenolic content, PW) white wines were compared. One- and three-month-old Sprague-Dawley male rats (n = 78) were used. Each age group was subdivided into water-only-drinking controls (C), W, and PW-drinking animals. Daily wine and total liquid consumption, food intake, and body weight were measured, and energy intake and feed efficiency index were calculated. Results In both age categories, wine-drinking animals consumed less food and gained less weight in comparison to C (181 ± 2, 179 ± 6, and 201 ± 5 in younger animals and 32 ± 5, 28 ± 6, and 47 ± 4 grams in older animals, resp.), regardless of wine type. Total energy intake was the lowest in PW-drinking animals. Conclusion Wine-drinking animals gained less weight in comparison to C, regardless of the wines' polyphenol content. Although our results are indicative of the major role of nonphenolic constituents of the wines (probably ethanol), the modifying role of wine phenolics on weight gain cannot be excluded as the group consuming PW had lower total energy intake than other groups.
Collapse
|
34
|
Prevalence of overweight, obesity, abdominal obesity and obesity-related risk factors in southern China. PLoS One 2017; 12:e0183934. [PMID: 28910301 PMCID: PMC5598943 DOI: 10.1371/journal.pone.0183934] [Citation(s) in RCA: 160] [Impact Index Per Article: 20.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 04/20/2017] [Accepted: 08/14/2017] [Indexed: 12/29/2022] Open
Abstract
Objectives The purpose of this study is to assess the prevalence of overweight/obesity, abdominal obesity and obesity-related risk factors in southern China. Methods A cross-sectional survey of 15,364 participants aged 15 years and older was conducted from November 2013 to August 2014 in Jiangxi Province, China, using questionnaire forms and physical measurements. The physical measurements included body height, weight, waist circumference (WC), body fat percentage (BFP) and visceral adipose index (VAI). Multivariate logistic regression analysis was performed to evaluate the risk factors for overweight/obesity and abdominal obesity. Results The prevalence of overweight was 25.8% (25.9% in males and 25.7% in females), while that of obesity was 7.9% (8.4% in males and 7.6% in females). The prevalence of abdominal obesity was 10.2% (8.6% in males and 11.3% in females). The prevalence of overweight/obesity was 37.1% in urban residents and 30.2% in rural residents, and this difference was significant (P < 0.001). Urban residents had a significantly higher prevalence of abdominal obesity than rural residents (11.6% vs 8.7%, P < 0.001). Among the participants with an underweight/normal body mass index (BMI), 1.3% still had abdominal obesity, 16.1% had a high BFP and 1.0% had a high VAI. Moreover, among obese participants, 9.7% had a low /normal WC, 0.8% had a normal BFP and 15.9% had a normal VAI. Meanwhile, the partial correlation analysis indicated that the correlation coefficients between VAI and BMI, VAI and WC, and BMI and WC were 0.700, 0.666, and 0.721, respectively. A multivariate logistic regression analysis indicated that being female and having a high BFP and a high VAI were significantly associated with an increased risk of overweight/obesity and abdominal obesity. In addition, living in an urban area and older age correlated with overweight/obesity. Conclusion This study revealed that obesity and abdominal obesity, which differed by gender and age, are epidemic in southern China. Moreover, there was a very high, significant, positive correlation between WC, BMI and VAI. However, further studies are needed to explore which indicator of body fat could be used as the best marker to indirectly reflect cardiometabolic risk.
Collapse
|
35
|
Feng X, Wilson A. Neighbourhood socioeconomic inequality and gender differences in body mass index: The role of unhealthy behaviours. Prev Med 2017; 101:171-177. [PMID: 28603005 DOI: 10.1016/j.ypmed.2017.06.002] [Citation(s) in RCA: 4] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 12/27/2016] [Revised: 05/28/2017] [Accepted: 06/05/2017] [Indexed: 12/12/2022]
Abstract
Reported differences in the severity of the social gradient in body mass index (BMI) by gender may be attributable to differences in behaviour. Self-reported height, weight, socioeconomic and behavioural data were obtained for a sample of 10,281 Australians aged ≥15years in 2009. Multilevel regressions were fitted with BMI as the outcome variable. Two-way interactions between gender and neighbourhood disadvantage were fitted, adjusted for confounders. Models were then adjusted for four behavioural factors ("chips, snacks and confectionary", "smoking, little fruit or veg", "time poor and less physically active" and "alcohol consumption"). Additional models were fitted on a subset with accurate perceptions of weight status (determined by World Health Organization criteria) to control for potential social desirability bias. Although higher BMI was observed for men in most disadvantaged compared with most affluent neighbourhoods (coefficient 0.87, 95% CI 0.35 to 1.40), this pattern was stronger among women (1.80, 95% CI 1.17 to 2.42). Adjusting for differences in behaviours attenuated, but did not fully explain the differences in social gradients observed for men (0.73, 95% CI 0.21 to 1.26) and women (1.73, 1.10 to 2.36). Differences in behaviour did not explain contrasting socioeconomic gradients in adult BMI by gender. Further research on differences in BMI, health and behaviour over time aligned with how heavy a person may perceive themselves to be is warranted.
Collapse
Affiliation(s)
- Xiaoqi Feng
- Population Wellbeing and Environment Research Lab (PowerLab), Faculty of Social Sciences, University of Wollongong, Wollongong, New South Wales, Australia; Early Start Research Institute, University of Wollongong, Wollongong, New South Wales, Australia; Menzies Centre for Health Policy, University of Sydney, Sydney, New South Wales, Australia.
| | - Andrew Wilson
- Menzies Centre for Health Policy, University of Sydney, Sydney, New South Wales, Australia; The Australian Prevention Partnership Centre, the Sax Institute, Sydney, New South Wales, Australia
| |
Collapse
|
36
|
Jayawardana NWIA, Jayalath WATA, Madhujith WMT, Ralapanawa U, Jayasekera RS, Alagiyawanna SASB, Bandara AMKR, Kalupahana NS. Lifestyle factors associated with obesity in a cohort of males in the central province of Sri Lanka: a cross-sectional descriptive study. BMC Public Health 2017; 17:27. [PMID: 28056898 PMCID: PMC5217224 DOI: 10.1186/s12889-016-3963-3] [Citation(s) in RCA: 9] [Impact Index Per Article: 1.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/28/2016] [Accepted: 12/20/2016] [Indexed: 12/17/2022] Open
Abstract
BACKGROUND Obesity has become a global epidemic. The prevalence of obesity has also increased in the South Asian region in the last decade. However, dietary and lifestyle factors associated with obesity in Sri Lankan adults are unclear. The objective of the current study was to investigate the association of dietary and lifestyle patterns with overweight and obesity in a cohort of males from the Central Province of Sri Lanka. METHODS A total of 2469 males aged between 16 and 72 years ([Formula: see text]) were included in the study. The sample comprised individuals who presented for a routine medical examination at the National Transport Medical Institute, Kandy, Sri Lanka. The Body Mass Index (BMI) cutoff values for Asians were used to categorize the participants into four groups as underweight, normal weight, overweight or obese. The data on dietary and lifestyle patterns such as level of physical activity, smoking, alcohol consumption, sleeping hours and other socio demographic data were obtained using validated self-administered questionnaires. Multinomial logistic regression model was fitted to assess the associations of individual lifestyle patterns with overweight and obesity. RESULTS The mean BMI of the study group was 22.7 kg m-2 and prevalence rates of overweight and obesity were 31.8 and 12.3%, respectively. Mean waist circumference of the participants was 78.6 cm with 17.1% of them being centrally obese. After adjusting for potential confounders, weight status was associated with older age (P < 0.0001), ethnicity (P = 0.0033) and higher income (P = 0.0006). While higher physical activity showed a trend for being associated with lower odds of being obese (odds ratio: 0.898 - confidence interval: 0.744-1.084), alcohol intake, consumption of fruits, level of education, sleeping hours, smoking, consumption of fish, meat, dairy, sweets or fried snacks were not significantly associated with the weight status. CONCLUSION The high prevalence rates of overweight and obesity in working-age males is a threatening sign for Sri Lanka. Since the prevalence rate is higher in certain ethnic groups and higher-income groups, targeted interventions for these groups may be necessary.
Collapse
Affiliation(s)
- N. W. I. A. Jayawardana
- Department of Animal and Food Sciences, Faculty of Agriculture, Rajarata University of Sri Lanka, Anuradhapura, Sri Lanka
| | - W. A. T. A. Jayalath
- Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
| | - W. M. T. Madhujith
- Department of Food Science and Technology, Faculty of Agriculture, University of Peradeniya, Peradeniya, Sri Lanka
| | - U. Ralapanawa
- Department of Medicine, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
| | | | | | - A. M. K. R. Bandara
- Department of Agricultural Systems, Faculty of Agriculture, Rajarata University of Sri Lanka, Anuradhapura, Sri Lanka
| | - N. S. Kalupahana
- Department of Physiology, Faculty of Medicine, University of Peradeniya, Peradeniya, Sri Lanka
| |
Collapse
|
37
|
Substitution Models of Water for Other Beverages, and the Incidence of Obesity and Weight Gain in the SUN Cohort. Nutrients 2016; 8:nu8110688. [PMID: 27809239 PMCID: PMC5133076 DOI: 10.3390/nu8110688] [Citation(s) in RCA: 31] [Impact Index Per Article: 3.4] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 07/30/2016] [Revised: 10/24/2016] [Accepted: 10/26/2016] [Indexed: 12/23/2022] Open
Abstract
Obesity is a major epidemic for developed countries in the 21st century. The main cause of obesity is energy imbalance, of which contributing factors include a sedentary lifestyle, epigenetic factors and excessive caloric intake through food and beverages. A high consumption of caloric beverages, such as alcoholic or sweetened drinks, may particularly contribute to weight gain, and lower satiety has been associated with the intake of liquid instead of solid calories. Our objective was to evaluate the association between the substitution of a serving per day of water for another beverage (or group of them) and the incidence of obesity and weight change in a Mediterranean cohort, using mathematical models. We followed 15,765 adults without obesity at baseline. The intake of 17 beverage items was assessed at baseline through a validated food-frequency questionnaire. The outcomes were average change in body weight in a four-year period and new-onset obesity and their association with the substitution of one serving per day of water for one of the other beverages. During the follow-up, 873 incident cases of obesity were identified. In substitution models, the consumption of water instead of beer or sugar-sweetened soda beverages was associated with a lower obesity incidence (the Odds Ratio (OR) 0.80 (95% confidence interval (CI) 0.68 to 0.94) and OR 0.85 (95% CI 0.75 to 0.97); respectively) and, in the case of beer, it was also associated with a higher average weight loss (weight change difference = −328 g; (95% CI −566 to −89)). Thus, this study found that replacing one sugar-sweetened soda beverage or beer with one serving of water per day at baseline was related to a lower incidence of obesity and to a higher weight loss over a four-year period time in the case of beer, based on mathematical models.
Collapse
|
38
|
Dodge T, Clarke P, Dwan R. The Relationship Between Physical Activity and Alcohol Use Among Adults in the United States. Am J Health Promot 2016; 31:97-108. [PMID: 27630108 DOI: 10.1177/0890117116664710] [Citation(s) in RCA: 52] [Impact Index Per Article: 5.8] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/28/2023]
Abstract
OBJECTIVE To synthesize published literature that has tested the relationship between physical activity and alcohol use. DATA SOURCE A systematic review of literature published between January 2005 and May 2015 was conducted by searching the databases: PsychInfo, Medline, and Pubmed. STUDY INCLUSION AND EXCLUSION CRITERIA Inclusion criteria: must have tested for the relationship between physical activity and alcohol use; used adult samples within the United States. EXCLUSION CRITERIA utilized samples from outside the United States, adolescents, or alcohol dependent and heavy drinkers. DATA EXTRACTION Data were extracted from studies that achieved a quality score of 4 or greater. The following information was recorded for each study: sample characteristics, the variable that served as the predictor, study design, covariates included in analyses, and the direction/nature of the relationship. DATA SYNTHESIS The search captured 1036 unique articles, 16 of which were included in the final systematic review. RESULTS Nearly 88% of the studies with college students and 75% of studies with nonstudent adults reported a positive relationship between physical activity and alcohol use. CONCLUSION Research published in the past decade implies a positive relationship between physical activity and alcohol use. Findings have important implications for the design of health promotion programs targeting physical activity and alcohol use.
Collapse
Affiliation(s)
- Tonya Dodge
- 1 Department of Psychology, George Washington University, Washington, DC, USA
| | - Paige Clarke
- 1 Department of Psychology, George Washington University, Washington, DC, USA
| | - Rita Dwan
- 1 Department of Psychology, George Washington University, Washington, DC, USA
| |
Collapse
|
39
|
Meyer KA, Guilkey DK, Tien HC, Kiefe CI, Popkin BM, Gordon-Larsen P. Instrumental-Variables Simultaneous Equations Model of Physical Activity and Body Mass Index: The Coronary Artery Risk Development in Young Adults (CARDIA) Study. Am J Epidemiol 2016; 184:465-76. [PMID: 27614300 PMCID: PMC5023789 DOI: 10.1093/aje/kww010] [Citation(s) in RCA: 1] [Impact Index Per Article: 0.1] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Grants] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 06/12/2015] [Accepted: 01/11/2016] [Indexed: 12/14/2022] Open
Abstract
We used full-system-estimation instrumental-variables simultaneous equations modeling (IV-SEM) to examine physical activity relative to body mass index (BMI; weight (kg)/height (m)(2)) using 25 years of data (1985/1986 to 2010/2011) from the Coronary Artery Risk Development in Young Adults (CARDIA) Study (n = 5,115; ages 18-30 years at enrollment). Neighborhood environment and sociodemographic instruments were used to characterize physical activity, fast-food consumption, smoking, alcohol consumption, marriage, and childbearing (women) and to predict BMI using semiparametric full-information maximum likelihood estimation to control for unobserved time-invariant and time-varying residual confounding and differential measurement error through model-derived discrete random effects. Comparing robust-variance ordinary least squares, random-effects regression, fixed-effects regression, single-equation-estimation IV-SEM, and full-system-estimation IV-SEM, estimates from random- and fixed-effects models and the full-system-estimation IV-SEM were unexpectedly similar, despite the lack of control for residual confounding with the random-effects estimator. Ordinary least squares tended to overstate the significance of health behaviors in BMI, while results from single-equation-estimation IV-SEM were notably different, revealing the impact of weak instruments in standard instrumental-variable methods. Our robust findings for fixed effects (which does not require instruments but has a high cost in lost degrees of freedom) and full-system-estimation IV-SEM (vs. standard IV-SEM) demonstrate potential for a full-system-estimation IV-SEM method even with weak instruments.
Collapse
Affiliation(s)
| | | | | | | | | | - Penny Gordon-Larsen
- Correspondence to Dr. Penny Gordon-Larsen, Department of Nutrition, Gillings School of Global Public Health, University of North Carolina at Chapel Hill, 137 East Franklin Street, 6th Floor, Campus Box #8120, Chapel Hill, NC 27514 (e-mail: )
| |
Collapse
|
40
|
Bang SH, Choi MR, Kwak SM, Choi IY, Rho MJ, Jung DJ, Han K, Kim DJ. Association Between Drinking and Obesity in Pre- and Postmenopausal Women: Korea National Health and Nutrition Examination Survey 2010-2012. J Womens Health (Larchmt) 2016; 25:1166-1173. [PMID: 27548609 DOI: 10.1089/jwh.2016.5866] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/12/2022] Open
Abstract
BACKGROUND Women are more vulnerable to the adverse effects of alcohol than men. The present study aimed to investigate the link between drinking and obesity in pre- and postmenopausal women in Korea. METHODS We performed a cross-sectional study of 4374 premenopausal and 2927 postmenopausal women using a multistage probability cluster survey sample to produce nationally representative estimates. We assessed the subjects' alcohol drinking tendencies rates according to their drinking levels as well as Alcohol Use Disorders Identification Test (AUDIT); obesity was identified based on body mass index (BMI) ≥25 kg/m2, waist circumference (WC) ≥80 cm, and waist-to-height ratio (WHtR) ≥50%. We performed t-tests and chi-square tests to assess the association between drinking and obesity. RESULTS In premenopausal subjects, obesity indices increased significantly as alcohol consumption rose. Significant correlations between drinking level and obesity factors were found in premenopausal women after adjusting for age (odds ratios [ORs] for BMI, WC, and WHtR were 1.58 [1.08-2.31], 1.94 [1.11-3.00], and 1.80 [1.24-2.61], respectively). Furthermore, an AUDIT score of 20 or higher indicated a significantly higher likelihood of obesity (ORs for BMI, WC, and WHtR were 2.02 [1.18-3.46], 2.75 [1.70-4.87], and 2.86 [1.78-4.59], respectively). There was a significant correlation between AUDIT scores and obesity factors after adjusting for age, energy intake, fat intake, exercise, smoking, education, and income in premenopausal women (ORs for BMI and WHtR were 1.71 [0.85-3.47] and 1.73 [0.97-3.06], respectively). CONCLUSION Our results suggest that alcohol is associated with a risk factor for obesity in premenopausal women.
Collapse
Affiliation(s)
- Sol Hee Bang
- 1 Department of Biomedical Science, The Catholic University of Korea College of Medicine , Seoul, Republic of Korea.,2 Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine , Seoul, Republic of Korea
| | - Mi Ran Choi
- 2 Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine , Seoul, Republic of Korea
| | - Su Min Kwak
- 1 Department of Biomedical Science, The Catholic University of Korea College of Medicine , Seoul, Republic of Korea.,2 Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine , Seoul, Republic of Korea
| | - In Young Choi
- 3 Department of Medical Informatics, The Catholic University of Korea College of Medicine , Seoul, Republic of Korea.,4 Institute of Healthcare Management, The Catholic University of Korea College of Medicine , Seoul, Republic of Korea
| | - Mi Jung Rho
- 3 Department of Medical Informatics, The Catholic University of Korea College of Medicine , Seoul, Republic of Korea.,4 Institute of Healthcare Management, The Catholic University of Korea College of Medicine , Seoul, Republic of Korea
| | - Dong Jin Jung
- 2 Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine , Seoul, Republic of Korea
| | - Kyungdo Han
- 5 Department of Biostatistics, The Catholic University of Korea College of Medicine , Seoul, Republic of Korea
| | - Dai-Jin Kim
- 1 Department of Biomedical Science, The Catholic University of Korea College of Medicine , Seoul, Republic of Korea.,2 Department of Psychiatry, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine , Seoul, Republic of Korea
| |
Collapse
|
41
|
da Rocha TF, Hasselmann MH, Chaves Curioni C, Bezerra FF, Faerstein E. Alcohol consumption is associated with DXA measurement of adiposity: the Pró-Saúde Study, Brazil. Eur J Nutr 2016; 56:1983-1991. [DOI: 10.1007/s00394-016-1240-y] [Citation(s) in RCA: 7] [Impact Index Per Article: 0.8] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Received: 05/06/2015] [Accepted: 05/30/2016] [Indexed: 10/21/2022]
|
42
|
Mogre V, Aleyira S, Nyaba R. Factors associated with central overweight and obesity in students attending the University for Development Studies in Tamale, Ghana: a cross-sectional study. SOUTH AFRICAN JOURNAL OF CLINICAL NUTRITION 2016. [DOI: 10.1080/16070658.2014.11734490] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 10/21/2022]
|
43
|
Lavin J, Pallister C, Greenwood L. The government must do more to raise awareness of the links between alcohol and obesity, rather than treating them as separate issues. Perspect Public Health 2016; 136:123-4. [DOI: 10.1177/1757913916640654] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/15/2022]
|
44
|
Budzyński J, Ziółkowski M, Kłopocka M, Czarnecki D. Blood glucose and lipid concentrations after overload are not associated with the risk of alcohol relapse. Drug Alcohol Depend 2016; 161:356-62. [PMID: 26948546 DOI: 10.1016/j.drugalcdep.2016.02.029] [Citation(s) in RCA: 2] [Impact Index Per Article: 0.2] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 09/23/2015] [Revised: 01/25/2016] [Accepted: 02/15/2016] [Indexed: 12/11/2022]
Abstract
AIMS There is evidence for the functioning of feedback between alcohol consumption and fat (positive) and carbohydrate (negative) intake. We tried to verify the hypothesis that blood glucose and lipid concentration in a fasting state and after loading may affect the risk of relapse in alcohol-dependent male patients during withdrawal therapy. METHODS Blood glucose, total cholesterol (TC) and triglycerides (TG) were determined at the beginning of the study, and again after 4 weeks and 6 months of observation in 54 alcohol-dependent male patients treated against drinking relapse. Glucose concentration was checked after fasting and 2h after loading with a 75 g water solution of glucose, and blood lipids were determined on an empty stomach and 5h after butter loading (0.5 g of butter per kilogram of body mass). RESULTS Patients who relapsed compared to subjects who remained abstinent during the 6-month observation did not differ significantly in relation to blood glucose, TC or TG blood concentrations, either in a fasting state or after loading. Patients with an initial above-median increase in TG blood concentration after butter loading (>38%) before the beginning of the study, and who smoked cigarettes with a greater content of nicotine and tar, preferred vodka and had lower values of aminotransferases. CONCLUSION Fasting and postprandial blood glucose, TC and TG concentrations had no relationship with the outcome of anti-relapse treatment. However, they presented some associations with the pathomechanism of addiction to nicotine.
Collapse
Affiliation(s)
- Jacek Budzyński
- Department of Vascular and Internal Medicine, Faculty of Health Sciences, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus Universisty, Toruń, Poland; Clinic of Vascular and Internal Diseases, Jan Biziel University Hospital No. 2, Bydgoszcz, Poland.
| | - Marcin Ziółkowski
- Department of Psychiatric Nursing, Faculty of Health Sciences, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland
| | - Maria Kłopocka
- Department of Vascular and Internal Medicine, Faculty of Health Sciences, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus Universisty, Toruń, Poland
| | - Damian Czarnecki
- Department of Psychiatric Nursing, Faculty of Health Sciences, The Ludwik Rydygier Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University, Toruń, Poland
| |
Collapse
|
45
|
Jia HJ, Zhang PJ, Liu YL, Jiang CG, Zhu X, Tian YP. Relationship of serum polyunsaturated fatty acids with cytokines in colorectal cancer. World J Gastroenterol 2016; 22:2524-2532. [PMID: 26937140 PMCID: PMC4768198 DOI: 10.3748/wjg.v22.i8.2524] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.6] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Submit a Manuscript] [Subscribe] [Scholar Register] [Received: 01/11/2016] [Revised: 02/03/2016] [Accepted: 02/20/2016] [Indexed: 02/06/2023] Open
Abstract
AIM To investigate the relationship of serum levels of polyunsaturated fatty acid (PUFA) with kinds of cytokines in colorectal cancer (CRC). METHODS Serum samples of 100 CRC patients were collected. The concentration of total n-3 PUFA which included C18:3 n-3, C20:5 n-3, C22:5 n-3, C22:6 n-3 and the total n-6 PUFA included C18:2 n-6, C18:3 n-6, C20:3 n-6, C20:4 n-6, and C22:5 n-6 were detected on GC-2010 Plus Gas Chromatograph with a OmegawaxTM 250 column. Cytokines were detected by MagPlexTM-C microspheres. P values for the trend were estimated by creating a continuous variable using the median value within quartiles. RESULTS Interleukin-6 (IL-6) showed significantly positive association with the C20:4 n-6 (P for trend = 0.004). Interferon gamma (IFN-γ) showed significant positive association with the C22:5 n-3 (P for trend = 0.035). IL-8 and matrix metalloproteinase-9 (MMP-9) showed significant inverse association with the C22:6 n-3 (P for trend = 0.049, and 0.021). MMP-2 showed significant inverse association with the C20:5 n-3 (P for trend = 0.008). MMP-7 showed significantly positive association with the ratio of n-6 PUFA and n-3 PUFA (P for trend = 0.008). MMP-7 also showed significantly inverse association with the ratio of C20:4 n-6 and (n-6 PUFA + n-3 PUFA) (P for trend = 0.024). IL-10 (P for trend = 0.023) and IL-6 (P for trend = 0.036) showed significantly positive association with the ratio of C20:4 n-6 and C20:5 n-3. CONCLUSION Our data suggested that serum levels of PUFA is related to the inflammation of CRC, and also play different role in regulation of immune response.
Collapse
|
46
|
Lafortune L, Martin S, Kelly S, Kuhn I, Remes O, Cowan A, Brayne C. Behavioural Risk Factors in Mid-Life Associated with Successful Ageing, Disability, Dementia and Frailty in Later Life: A Rapid Systematic Review. PLoS One 2016; 11:e0144405. [PMID: 26845035 PMCID: PMC4742275 DOI: 10.1371/journal.pone.0144405] [Citation(s) in RCA: 109] [Impact Index Per Article: 12.1] [Reference Citation Analysis] [Abstract] [MESH Headings] [Track Full Text] [Download PDF] [Figures] [Journal Information] [Subscribe] [Scholar Register] [Received: 08/17/2015] [Accepted: 10/18/2015] [Indexed: 12/13/2022] Open
Abstract
BACKGROUND Smoking, alcohol consumption, poor diet and low levels of physical activity significantly contribute to the burden of illness in developed countries. Whilst the links between specific and multiple risk behaviours and individual chronic conditions are well documented, the impact of these behaviours in mid-life across a range of later life outcomes has yet to be comprehensively assessed. This review aimed to provide an overview of behavioural risk factors in mid-life that are associated with successful ageing and the primary prevention or delay of disability, dementia, frailty and non-communicable chronic conditions. METHODS A literature search was conducted to identify cohort studies published in English since 2000 up to Dec 2014. Multivariate analyses and a minimum follow-up of five years were required for inclusion. Two reviewers screened titles, abstracts and papers independently. Studies were assessed for quality. Evidence was synthesised by mid-life behavioural risk for a range of late life outcomes. FINDINGS This search located 10,338 individual references, of which 164 are included in this review. Follow-up data ranged from five years to 36 years. Outcomes include dementia, frailty, disability and cardiovascular disease. There is consistent evidence of beneficial associations between mid-life physical activity, healthy ageing and disease outcomes. Across all populations studied there is consistent evidence that mid-life smoking has a detrimental effect on health. Evidence specific to alcohol consumption was mixed. Limited, but supportive, evidence was available relating specifically to mid-life diet, leisure and social activities or health inequalities. CONCLUSIONS There is consistent evidence of associations between mid-life behaviours and a range of late life outcomes. The promotion of physical activity, healthy diet and smoking cessation in all mid-life populations should be encouraged for successful ageing and the prevention of disability and chronic disease.
Collapse
Affiliation(s)
- Louise Lafortune
- Institute of Public Health, Forvie Site, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom
| | - Steven Martin
- Institute of Public Health, Forvie Site, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom
| | - Sarah Kelly
- Institute of Public Health, Forvie Site, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom
| | - Isla Kuhn
- University of Cambridge Medical Library, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom
| | - Olivia Remes
- Institute of Public Health, Forvie Site, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom
| | - Andy Cowan
- Institute of Public Health, Forvie Site, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom
| | - Carol Brayne
- Institute of Public Health, Forvie Site, University of Cambridge School of Clinical Medicine, Cambridge Biomedical Campus, Cambridge, United Kingdom
| |
Collapse
|
47
|
Trajectories of Body Mass Index from Young Adulthood to Middle Age among Canadian Men and Women. ACTA ACUST UNITED AC 2015. [DOI: 10.1155/2015/121806] [Citation(s) in RCA: 10] [Impact Index Per Article: 1.0] [Reference Citation Analysis] [Abstract] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 11/18/2022]
Abstract
Knowledge regarding the heterogeneity of BMI trajectories is limited for the Canadian population. Using latent class growth modelling, four distinct BMI trajectories of individuals from young adulthood to middle age were identified for both women and men from the longitudinal data of the National Population Health Survey. The associations between BMI trajectories and the individuals’ sociodemographic characteristics and behavioural factors were also examined. Aboriginal women were found more likely to be in the long-term overweight or obese groups. It reveals that increased years of smoking, drinking, and being physically active were associated with lowering the BMI trajectory in all groups for both women and men, with some exceptions in the long-term normal weight group for men. Increased years of rural living, being employed, and living with low income were associated with raising the BMI trajectory in all groups for women and in some groups for men. Food insecurity was associated with raising the BMI trajectory in each group for both women and men.
Collapse
|
48
|
Lifestyle Factors and Metabolic Syndrome among Workers: The Role of Interactions between Smoking and Alcohol to Nutrition and Exercise. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH 2015; 12:15967-78. [PMID: 26694434 PMCID: PMC4690971 DOI: 10.3390/ijerph121215035] [Citation(s) in RCA: 22] [Impact Index Per Article: 2.2] [Reference Citation Analysis] [Abstract] [Key Words] [Track Full Text] [Download PDF] [Subscribe] [Scholar Register] [Received: 10/11/2015] [Revised: 12/10/2015] [Accepted: 12/11/2015] [Indexed: 12/14/2022]
Abstract
This study aimed to investigate (1) relations of smoking and alcohol to metabolic syndrome (MetS) and its components, with nutrition and exercise controlled; and (2) interactions between smoking/alcohol and nutrition/exercise on MetS. This cross-sectional study enrolled 4025 workers. Self-reported lifestyles, anthropometric values, blood pressure (BP), and biochemical determinations were obtained. Among males, smoking significantly increased the risk of low high-density lipoprotein cholesterol (HDL-C), high triglyceride, abdominal obesity (AO), and MetS. Additionally, smoking showed significant interaction effects with nutrition on high BP, AO, and MetS; after further analysis, nutrition did not decrease above-mentioned risks for smokers. However, there was no significant interaction of smoking with exercise on any metabolic parameter. Alcohol increased the risk of AO, but decreased low HDL-C. It also showed an interaction effect with exercise on AO; after further analysis, exercise decreased AO risk for drinkers. Among females, alcohol significantly decreased the risk of high fasting blood glucose, but did not show significant interaction with nutrition/exercise on any metabolic parameter. In conclusion, in males, smoking retained significant associations with MetS and its components, even considering benefits of nutrition; exercise kept predominance on lipid parameters regardless of smoking status. Alcohol showed inconsistencies on metabolic parameters for both genders.
Collapse
|
49
|
Addo PNO, Nyarko KM, Sackey SO, Akweongo P, Sarfo B. Prevalence of obesity and overweight and associated factors among financial institution workers in Accra Metropolis, Ghana: a cross sectional study. BMC Res Notes 2015; 8:599. [PMID: 26499885 PMCID: PMC4619450 DOI: 10.1186/s13104-015-1590-1] [Citation(s) in RCA: 38] [Impact Index Per Article: 3.8] [Reference Citation Analysis] [Abstract] [Key Words] [MESH Headings] [Track Full Text] [Download PDF] [Journal Information] [Subscribe] [Scholar Register] [Received: 01/14/2015] [Accepted: 10/14/2015] [Indexed: 01/19/2023] Open
Abstract
BACKGROUND Certain professions are associated with low physical activity. Workers in such professions spend the most part of their adult working lives less engaged in physical activity if they don't consciously exercise outside of working hours. This increases their risk of obesity and its associated diseases. This study determined the prevalence of obesity and overweight and associated factors among workers of a financial institution in Accra Metropolis, Ghana. METHODS A cross-sectional study was conducted among 180 workers of a financial institution in Accra using the World Health Organization's STEPS (STEPwise approach) instrument for non-communicable disease risk factor surveillance. Relevant sociodemographic information were recorded and BMI was computed for each respondent. RESULTS The overall prevalence of obesity and overweight among the bank workers was 55.6 % (17.8 % obese and 37.8 % overweight). After adjusting for other variables, physical activity (OR = 0.34, 95 % CI = 0.13-0.89, p = 0.03), alcohol consumption (OR = 3.00, 95 % CI = 1.35, 6.68, p = 0.007), marital status (OR = 2.74, 95 % CI = 0.96-7.85, p = 0.04), sex (OR = 2.78, 95 % CI = 1.23-6.33, p = 0.01), and age (OR = 1.10, 95 % CI = 1.01-1.20, p = 0.036) were significantly associated with obesity and overweight. CONCLUSION Being physically inactive, consumption of alcohol, being married and a female, in addition to old age, increase the risk of obesity and overweight significantly. These factors should inform policy makers in developing strategies to reduce the burden of obesity and overweight among this category of workers.
Collapse
Affiliation(s)
- Prince N O Addo
- Department of Epidemiology and Disease Control, School of Public Health, College of Health Sciences, University of Ghana, P. O. Box LG 13, Legon, Accra, Ghana.
| | - Kofi M Nyarko
- Department of Epidemiology and Disease Control, School of Public Health, College of Health Sciences, University of Ghana, P. O. Box LG 13, Legon, Accra, Ghana.
- Non Communicable Diseases Control Program, Ghana Health Service, Box KB 493, Korle-Bu, Accra, Ghana.
| | - Samuel O Sackey
- Department of Epidemiology and Disease Control, School of Public Health, College of Health Sciences, University of Ghana, P. O. Box LG 13, Legon, Accra, Ghana.
| | - Patricia Akweongo
- Department of Epidemiology and Disease Control, School of Public Health, College of Health Sciences, University of Ghana, P. O. Box LG 13, Legon, Accra, Ghana.
| | - Bismark Sarfo
- Department of Epidemiology and Disease Control, School of Public Health, College of Health Sciences, University of Ghana, P. O. Box LG 13, Legon, Accra, Ghana.
| |
Collapse
|
50
|
N'Goran AA, Studer J, Deline S, Henchoz Y, Baggio S, Mohler-Kuo M, Daeppen JB, Gmel G. Bidirectional relationship between the body mass index and substance use in young men. Subst Abus 2015; 37:190-6. [DOI: 10.1080/08897077.2015.1013204] [Citation(s) in RCA: 5] [Impact Index Per Article: 0.5] [Reference Citation Analysis] [Track Full Text] [Journal Information] [Subscribe] [Scholar Register] [Indexed: 01/04/2023]
|