| For: | Wang K, Baldwin GS, Nikfarjam M, He H. p21-activated kinase signalling in pancreatic cancer: New insights into tumour biology and immune modulation. World J Gastroenterol 2018; 24(33): 3709-3723 [PMID: 30197477 DOI: 10.3748/wjg.v24.i33.3709] |
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| URL: | https://www.wjgnet.com/1007-9327/full/v24/i33/3709.htm |
| Number | Citing Articles |
| 1 |
Arian Ansardamavandi, Chelsea Dumesny, Yi Ma, Li Dong, Sarah Ellis, Ching-Seng Ang, Mehrdad Nikfarjam, Hong He. P-21 Kinase 1 or 4 Knockout Stimulated Anti-Tumour Immunity Against Pancreatic Cancer by Enhancing Vascular Normalisation. International Journal of Molecular Sciences 2025; 26(17) doi: 10.3390/ijms26178357
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| 2 |
Keita Yamada, Kiyoshi Higashi, Hirohisa Nagahori, Koichi Saito. Circulating natural antibodies against 3’-sialyllactose complement the diagnostic performance of CA19-9 for the early detection of pancreatic ductal adenocarcinoma. Cancer Biomarkers 2019; 27(1) doi: 10.3233/CBM-190158
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| 3 |
Charudatt Samant, Ramesh Kale, Anand Bokare, Mahip Verma, K. Sreedhara Ranganath Pai, Mandar Bhonde. PAK4 inhibition significantly potentiates Gemcitabine activity in PDAC cells via inhibition of Wnt/β-catenin, p-ERK/MAPK and p-AKT/PI3K pathways. Biochemistry and Biophysics Reports 2023; 35 doi: 10.1016/j.bbrep.2023.101544
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| 4 |
Ying Zhou, Jian Zhang, Jian Wang, Mao‐Sheng Cheng, Dong‐Mei Zhao, Feng Li. Targeting PAK1 with the Small Molecule Drug AK963/40708899 Suppresses Gastric Cancer Cell Proliferation and Invasion by Downregulation of PAK1 Activity and PAK1‐Related Signaling Pathways. The Anatomical Record 2019; 302(9) doi: 10.1002/ar.24095
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| 5 |
Baoyu Li, Bin Liu, Xianglian Zhang, Hui Liu, Lijie He. KIF18B promotes the proliferation of pancreatic ductal adenocarcinoma via activating the expression of CDCA8. Journal of Cellular Physiology 2020; 235(5) doi: 10.1002/jcp.29201
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| 6 |
Weikang Kong, Lingxia Zhu, Tian Li, Jiao Chen, Bo Fan, Wenjing Ji, Chunli Zhang, Xueting Cai, Chunping Hu, Xiaoyan Sun, Peng Cao. Azeliragon inhibits PAK1 and enhances the therapeutic efficacy of AKT inhibitors in pancreatic cancer. European Journal of Pharmacology 2023; 948 doi: 10.1016/j.ejphar.2023.175703
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| 7 |
Arian Ansardamavandi, Mehrdad Nikfarjam, Hong He. PAK in Pancreatic Cancer-Associated Vasculature: Implications for Therapeutic Response. Cells 2023; 12(23) doi: 10.3390/cells12232692
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| 8 |
Hong He, Chelsea Dumesny, Ching-Seng Ang, Li Dong, Yi Ma, Jun Zeng, Mehrdad Nikfarjam. A novel PAK4 inhibitor suppresses pancreatic cancer growth and enhances the inhibitory effect of gemcitabine. Translational Oncology 2022; 16 doi: 10.1016/j.tranon.2021.101329
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| 9 |
Irene Ramos-Alvarez, Robert T. Jensen. The Important Role of p21-Activated Kinases in Pancreatic Exocrine Function. Biology 2025; 14(2) doi: 10.3390/biology14020113
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| 10 |
Julie Auwercx, Bernadette Neve, Alison Vanlaeys, Mathilde Fourgeaud, Ingrid Bourrin-Reynard, Mouloud Souidi, Sylvie Brassart-Pasco, Frédéric Hague, Stéphanie Guenin, Belinda Duchene, Laurent Gutierrez, Olivier Destaing, Isabelle Dhennin-Duthille, Isabelle Van Seuningen, Nicolas Jonckheere, Mathieu Gautier. The kinase domain of TRPM7 interacts with PAK1 and regulates pancreatic cancer cell epithelial-to-mesenchymal transition. Cell Death & Disease 2025; 16(1) doi: 10.1038/s41419-025-07665-2
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| 11 |
Arian Ansardamavandi, Chelsea Dumesny, Sarah Ellis, Ching-Seng Ang, Mehrdad Nikfarjam, Hong He. Targeting PAK1 or PAK4 Uncovers Different Mechanisms of Vascular Reprogramming in Pancreatic Cancer. Cells 2025; 14(22) doi: 10.3390/cells14221806
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| 12 |
Chen Lu, Wei Jiang, Bingqing Hui, Dawei Rong, Kai Fu, Chaoxi Dong, Weiwei Tang, Hongyong Cao. The circ_0021977/miR‐10b‐5p/P21 and P53 regulatory axis suppresses proliferation, migration, and invasion in colorectal cancer. Journal of Cellular Physiology 2020; 235(3) doi: 10.1002/jcp.29135
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| 13 |
Dongdong Wang, Ji Zhu, Yuanqing Yang, Zhizhou Wang, Zhengran Ying, Hailong Zhang. The role of the miR-4306/PAK6 axis in degenerative nucleus pulposus cells in human intervertebral disc degeneration. Cellular Signalling 2023; 102 doi: 10.1016/j.cellsig.2022.110528
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| 14 |
Wenting Wang, Zhijian Xu, Ning Wang, Ruyong Yao, Tao Qin, Hao Lin, Lu Yue. Prognostic value of eight immune gene signatures in pancreatic cancer patients. BMC Medical Genomics 2021; 14(1) doi: 10.1186/s12920-020-00868-w
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| 15 |
Young-Lan Park, Sang-Yoon Ha, Sun-Young Park, Jung-Ho Choi, Min-Woo Jung, Dae-Seong Myung, Hyun-Soo Kim, Young-Eun Joo. Reversine induces cell cycle arrest and apoptosis via upregulation of the Fas and DR5 signaling pathways in human colorectal cancer cells. International Journal of Oncology 2019; doi: 10.3892/ijo.2019.4746
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| 16 |
Jian-Bo Shao, Xiang-Qian Luo, Li-Hua Mo, Gui Yang, Zhi-Qiang Liu, Jiang-Qi Liu, Zhi-Gang Liu, Da-Bo Liu, Ping-Chang Yang. Twist1 sustains the apoptosis resistance in eosinophils in nasal mucosa of allergic rhinitis. Archives of Biochemistry and Biophysics 2021; 702 doi: 10.1016/j.abb.2021.108828
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| 17 |
Nikolaos Symeonidis, Maria Lambropoulou, Efstathios Pavlidis, Constantinos Anagnostopoulos, Alexandra Tsaroucha, Athanasia Kotini, Christina Nikolaidou, Anastasia Kiziridou, Constantinos Simopoulos. PAK1 Expression in Pancreatic Cancer: Clinicopathological Characteristics and Prognostic Significance. Clinical Medicine Insights: Oncology 2019; 13 doi: 10.1177/1179554919831990
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| 18 |
Qin Yang, Yingchao Zhao, Yeshan Chen, Yu Chang, Ai Huang, Tie Xu, Guiling Li, Gang Wu. PAK6 promotes cervical cancer progression through activation of the Wnt/β‑catenin signaling pathway. Oncology Letters 2020; 20(3) doi: 10.3892/ol.2020.11797
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| 19 |
Yi Ma, Mehrdad Nikfarjam, Hong He. The trilogy of P21 activated kinase, autophagy and immune evasion in pancreatic ductal adenocarcinoma. Cancer Letters 2022; 548 doi: 10.1016/j.canlet.2022.215868
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| 20 |
Mingzhe Li, Jiaxin Zhou, Zhengkui Zhang, Jisong Li, Feng Wang, Ling Ma, Xiaodong Tian, Zebin Mao, Yinmo Yang. Exosomal miR-485-3p derived from pancreatic ductal epithelial cells inhibits pancreatic cancer metastasis through targeting PAK1. Chinese Medical Journal 2022; 135(19) doi: 10.1097/CM9.0000000000002154
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| 21 |
Kinjal Shah, Julhash U. Kazi. Phosphorylation-Dependent Regulation of WNT/Beta-Catenin Signaling. Frontiers in Oncology 2022; 12 doi: 10.3389/fonc.2022.858782
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| 22 |
Xiaodong Li, Feng Li. p21-Activated Kinase: Role in Gastrointestinal Cancer and Beyond. Cancers 2022; 14(19) doi: 10.3390/cancers14194736
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| 23 |
Kai Wang, Yifan Zhan, Nhi Huynh, Chelsea Dumesny, Xiao Wang, Khashayer Asadi, David Herrmann, Paul Timpson, Yang Yang, Katrina Walsh, Graham S. Baldwin, Mehrdad Nikfarjam, Hong He. Inhibition of PAK1 suppresses pancreatic cancer by stimulation of anti-tumour immunity through down-regulation of PD-L1. Cancer Letters 2020; 472 doi: 10.1016/j.canlet.2019.12.020
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| 24 |
Kai Wang, Hong He. Tumor Microenvironments in Organs. Advances in Experimental Medicine and Biology 2020; 1296 doi: 10.1007/978-3-030-59038-3_15
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| 25 |
Wei Mu, Zhe Wang, Margot Zöller. Ping-Pong—Tumor and Host in Pancreatic Cancer Progression. Frontiers in Oncology 2019; 9 doi: 10.3389/fonc.2019.01359
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| 26 |
Yingyi Liu, Sze-Nga Wong, Aiping Lyu, Joshua Ka-Shun Ko. Advancement in preclinical development of cancer treatment agents through modulation of Rac1: From EHop-016 to natural products. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2026; 1881(1) doi: 10.1016/j.bbcan.2025.189522
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| 27 |
Lizhou Xu, Farid N. Faruqu, Yau M. Lim, Kee Y. Lim, Revadee Liam-Or, Adam A. Walters, Paul Lavender, David Fear, Claire M. Wells, Julie Tzu-Wen Wang, Khuloud T. Al-Jamal. Exosome-mediated RNAi of PAK4 prolongs survival of pancreatic cancer mouse model after loco-regional treatment. Biomaterials 2021; 264 doi: 10.1016/j.biomaterials.2020.120369
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| 28 |
Kai Wang, Lili Yan, Xun Qiu, Huan Chen, Fengqiang Gao, Wenwen Ge, Zhengxing Lian, Xuyong Wei, Shuai Wang, Hong He, Xiao Xu. PAK1 inhibition increases TRIM21-induced PD-L1 degradation and enhances responses to anti-PD-1 therapy in pancreatic cancer. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2024; 1870(6) doi: 10.1016/j.bbadis.2024.167236
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| 29 |
Stefania Belli, Ada Pesapane, Alberto Servetto, Daniela Esposito, Fabiana Napolitano, Claudia Maria Ascione, Alessandra Allotta, Nicola Zambrano, Federica Zito Marino, Renato Franco, Teresa Troiani, Luigi Formisano, Roberto Bianco. Combined blockade of mTOR and p21-activated kinases pathways prevents tumour growth in KRAS-mutated colorectal cancer. British Journal of Cancer 2023; 129(7) doi: 10.1038/s41416-023-02390-z
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| 30 |
Hsing-Yu Wu, Ming-Chen Yang, Li-Yun Ding, Ching S. Chen, Po-Chen Chu. p21-Activated kinase 3 promotes cancer stem cell phenotypes through activating the Akt-GSK3β-β-catenin signaling pathway in pancreatic cancer cells. Cancer Letters 2019; 456 doi: 10.1016/j.canlet.2019.04.026
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| 31 |
Fangfang Zhuo, Shuang Luo, Wei He, Zhanhui Feng, Ya’nan Hu, Jingxia Xu, Zejun Wang, Jianwei Xu. The Role of Signaling Pathways in Pancreatic Cancer Targeted Therapy. American Journal of Clinical Oncology 2023; 46(3) doi: 10.1097/COC.0000000000000979
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| 32 |
Mohamed El-Tanani, Hamdi Nsairat, Ismail I. Matalka, Alaa A. A. Aljabali, Vijay Mishra, Yachana Mishra, Gowhar A. Naikoo, Sai Raghuveer Chava, Nitin B. Charbe, Murtaza M. Tambuwala. Impact of exosome therapy on pancreatic cancer and its progression. Medical Oncology 2023; 40(8) doi: 10.1007/s12032-023-02101-x
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