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For: Ballester V, Rashtak S, Boardman L. Clinical and molecular features of young-onset colorectal cancer. World J Gastroenterol 2016; 22(5): 1736-1744 [PMID: 26855533 DOI: 10.3748/wjg.v22.i5.1736]
URL: https://www.wjgnet.com/1007-9327/full/v22/i5/1736.htm
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Number Citing Articles
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Heyam Awad, Sanad Elshebli, Khaled Hasan, Yousef Eid, Fatima Obeidat, Mohammad Alzyoud, Basheer Alakhras, Faris AlShammas. Comparing Clinicopathological and Immunohistochemical Features of Colorectal Carcinoma between Young and Old Age Groups. Diagnostics 2024; 14(16) doi: 10.3390/diagnostics14161743
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Sameh Hany Emile, Hossam Elfeki, Mostafa Shalaby, Saleh Elbalka, Islam Hany Metwally, Mohamed Abdelkhalek. Patients with early-onset rectal cancer aged 40 year or less have similar oncologic outcomes to older patients despite presenting in more advanced stage; A retrospective cohort study. International Journal of Surgery 2020; 83 doi: 10.1016/j.ijsu.2020.09.029
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Christopher H. Lieu, Erica A. Golemis, Ilya G. Serebriiskii, Justin Newberg, Amanda Hemmerich, Caitlin Connelly, Wells A. Messersmith, Cathy Eng, S. Gail Eckhardt, Garrett Frampton, Matthew Cooke, Joshua E. Meyer. Comprehensive Genomic Landscapes in Early and Later Onset Colorectal Cancer. Clinical Cancer Research 2019; 25(19) doi: 10.1158/1078-0432.CCR-19-0899
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Ei-Wen Yang, Brigette Waldrup, Enrique Velazquez-Villarreal. From Mutation to Prognosis: AI-HOPE-PI3K Enables Artificial Intelligence Agent-Driven Integration of PI3K Pathway Data in Colorectal Cancer Precision Medicine. International Journal of Molecular Sciences 2025; 26(13) doi: 10.3390/ijms26136487
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Ilya G. Serebriiskii, Caitlin Connelly, Garrett Frampton, Justin Newberg, Matthew Cooke, Vince Miller, Siraj Ali, Jeffrey S. Ross, Elizabeth Handorf, Sanjeevani Arora, Christopher Lieu, Erica A. Golemis, Joshua E. Meyer. Comprehensive characterization of RAS mutations in colon and rectal cancers in old and young patients. Nature Communications 2019; 10(1) doi: 10.1038/s41467-019-11530-0
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Julieth Suarez Oceguera, Andria De la Cruz de Oña, Yanet Ortega Dugrot, Yandys Salas de la Cruz. Computed tomography hydroenema as a diagnostic alternative for colon tumors. Health Leadership and Quality of Life 2024; 3 doi: 10.56294/hl2024.335
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Hui Ren, Zhi Li, Zhengjun Tang, Jun Li, Xiaoou Lang. Long noncoding MAGI2‐AS3 promotes colorectal cancer progression through regulating miR‐3163/TMEM106B axis. Journal of Cellular Physiology 2020; 235(5) doi: 10.1002/jcp.29360
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Likun Yan, Jianfeng Yao, Jian Qiu. miRNA-495 suppresses proliferation and migration of colorectal cancer cells by targeting FAM83D. Biomedicine & Pharmacotherapy 2017; 96 doi: 10.1016/j.biopha.2017.11.138
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Minh Duc Do, Thinh Huu Nguyen, Khuong Thai Le, Linh Hoang Gia Le, Bac Hoang Nguyen, Kien Trung Le, Thao Phuong Thi Doan, Chuong Quoc Ho, Hoai‐Nghia Nguyen, Tuan Diep Tran, Hoang Anh Vu. Molecular characteristics of young‐onset colorectal cancer in Vietnamese patients. Asia-Pacific Journal of Clinical Oncology 2022; 18(6) doi: 10.1111/ajco.13749
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Victoria A. Belova, Liudmila V. Spirina, Alexandra V. Avgustinovich, Sergey G. Afanas'ev, Maxim Y. Volkov, Daniil I. Azovsky, Alexander M. Volkov, Tatyana S. Klyushina. New Perspectives in Colorectal Cancers Treatment, the Role of MicroRNAs. Current Drug Targets 2024; 25(11) doi: 10.2174/0113894501304351240703113651
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Jiading Mao, Pei Wu, Jian Wu, Liang Tao, Ping Wu, Guang Yang, Wenwen Guo, Jun Wang. Role of p38 Signaling Pathway in Pentagastrin-Regulated Cell Proliferation of Colorectal Carcinoma Cell Line HT-29. Journal of Cancer Therapy 2016; 7(06) doi: 10.4236/jct.2016.76041
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Amelie Tiritilli, Cynthia Ko. Patients with Early-Onset Colorectal Cancer Have an Increased Risk of Second Primary Malignancy. Digestive Diseases and Sciences 2022; 67(4) doi: 10.1007/s10620-021-06971-x
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Li Liu, Daniel Nevo, Reiko Nishihara, Yin Cao, Mingyang Song, Tyler S. Twombly, Andrew T. Chan, Edward L. Giovannucci, Tyler J. VanderWeele, Molin Wang, Shuji Ogino. Utility of inverse probability weighting in molecular pathological epidemiology. European Journal of Epidemiology 2018; 33(4) doi: 10.1007/s10654-017-0346-8
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Chao Liu, Yong Wang. KRAS/NRAS/BRAF Mutations and Mismatch Repair Deficiency in Patients with Early-Onset Colorectal Cancer: A Clinicopathological Analysis. International Journal of Surgical Pathology 2026;  doi: 10.1177/10668969261457880
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Dominic Worku. What are the Clinicopathological Features and Outcomes of Sporadic Colorectal Cancer (CRC) in an Ethiopian Cohort with focus on young-onset CRC?. Journal of Cancer Prevention & Current Research 2017; 8(3) doi: 10.15406/jcpcr.2017.08.00276
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Katie Kanter, Madeleine Fish, Gianluca Mauri, Nora K. Horick, Jill N. Allen, Lawrence S. Blaszkowsky, Jeffrey W. Clark, David P. Ryan, Ryan D. Nipp, Bruce J. Giantonio, Lipika Goyal, Jon Dubois, Janet E. Murphy, Joseph Franses, Samuel J. Klempner, Eric J. Roeland, Colin D. Weekes, Jennifer Y. Wo, Theodore S. Hong, Emily E. Van Seventer, Ryan B. Corcoran, Aparna R. Parikh. Care Patterns and Overall Survival in Patients With Early-Onset Metastatic Colorectal Cancer. JCO Oncology Practice 2021; 17(12) doi: 10.1200/OP.20.01010
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Jon Ambæk Durhuus, Christina Therkildsen, Thomas Kallemose, Mef Nilbert. Colorectal cancer in adolescents and young adults with Lynch syndrome: a Danish register-based study. BMJ Open 2021; 11(12) doi: 10.1136/bmjopen-2021-053538
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Sami Benli, Tahsin Colak, Mehmet Özgür Türkmenoğlu, Habip Sari, Caner Baysan. Do We Underestimate Colorectal Cancer Patients Under 50?. Polish Journal of Surgery 2022; 95(1) doi: 10.5604/01.3001.0015.8386
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D Saraste, J Järås, A Martling. Population-based analysis of outcomes with early-age colorectal cancer. British Journal of Surgery 2020; 107(3) doi: 10.1002/bjs.11333
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Satoru Furuhashi, Matias A. Bustos, Shodai Mizuno, Suyeon Ryu, Yalda Naeini, Anton J. Bilchik, Dave S. B. Hoon. Spatial profiling of cancer-associated fibroblasts of sporadic early onset colon cancer microenvironment. npj Precision Oncology 2023; 7(1) doi: 10.1038/s41698-023-00474-w
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Jonathan Bliggenstorfer, Katherine Bingmer, Asya Ofshteyn, Anuja L Sarode, Meridith Ginesi, Sharon L Stein, Emily Steinhagen. Evaluation of Demographics and Management of Rectal Cancer by Age Group: A Retrospective Propensity Matched Cohort Analysis of the National Cancer Database. Cureus 2021;  doi: 10.7759/cureus.19412
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Joy Zhou Done, Sandy H Fang. Young-onset colorectal cancer: A review. World Journal of Gastrointestinal Oncology 2021; 13(8): 856-866 doi: 10.4251/wjgo.v13.i8.856
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Melissa W. Taggart, Wai Chin Foo, Sun Mi Lee. Oncological Surgical Pathology. 2020;  doi: 10.1007/978-3-319-96681-6_12
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Giulia Martina Cavestro, José Perea, Milena Di Leo, Riccardo Rosati, Raffaella Alessia Zuppardo, Alessandro Mannucci. Colorectal cancer screening from 45 years of age: Thesis, antithesis and synthesis. World Journal of Gastroenterology 2019; 25(21): 2565-2580 doi: 10.3748/wjg.v25.i21.2565
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Jingjing Zhang, Tiaotiao Chen, Wencheng Wu, Chunhua Hu, Bangting Wang, Xiaofeng Jia, Mujie Ye. Carbonyl reductase 4 suppresses colorectal cancer progression through the DNMT3B/CBR4/FASN/mTOR axis. Cancer Cell International 2025; 25(1) doi: 10.1186/s12935-025-03776-0
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Yanqiu Gong, Yu Liu, Tian Wang, Zhigui Li, Li Gao, Haining Chen, Yang Shu, Yuan Li, Heng Xu, Zongguang Zhou, Lunzhi Dai. Age-Associated Proteomic Signatures and Potential Clinically Actionable Targets of Colorectal Cancer. Molecular & Cellular Proteomics 2021; 20 doi: 10.1016/j.mcpro.2021.100115
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Melani Ratih Mahanani, Simone Kaucher, Hiltraud Kajüter, Bernd Holleczek, Heiko Becher, Volker Winkler. Colorectal Cancer among Resettlers from the Former Soviet Union and in the General German Population: Clinical and Pathological Characteristics and Trends. International Journal of Environmental Research and Public Health 2021; 18(9) doi: 10.3390/ijerph18094547
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Robert K. Parker, Sinkeet S. Ranketi, Calvin McNelly, Matilda Ongondi, Hillary M. Topazian, Sanford M. Dawsey, Gwen A. Murphy, Russell E. White, Michael Mwachiro. Colorectal cancer is increasing in rural Kenya: challenges and perspectives. Gastrointestinal Endoscopy 2019; 89(6) doi: 10.1016/j.gie.2018.12.003
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Bradford J. Kim, Mark H. Hanna. Colorectal cancer in young adults. Journal of Surgical Oncology 2023; 127(8) doi: 10.1002/jso.27320
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Alain Fiorot, Anna Pozza, Cesare Ruffolo, Ezio Caratozzolo, Luca Bonariol, Francesco Enrico D’Amico, Luigi Padoan, Francesco Calia di Pinto, Marco Scarpa, Carlo Castoro, Nicolò Bassi, Marco Massani. Colorectal cancer in the young: a possible role for immune surveillance?. Acta Chirurgica Belgica 2018; 118(1) doi: 10.1080/00015458.2017.1353233
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Jan T Lowery, Thomas K Weber, Dennis J Ahnen, Paul C Schroy III, Caleb L Levell, Robert A Smith. An action plan to address the rising burden of colorectal cancer in younger adults. Colorectal Cancer 2020; 9(3) doi: 10.2217/crc-2020-0004
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In Jun Yang, Duck‐Woo Kim, Jeehye Lee, Hong‐Min Ahn, Heung‐Kwon Oh, Sung‐Bum Kang, Jung Wook Suh, Min Hyun Kim, Hyeon Jeong Oh, Hyung Kyung Kim, Min Jung Kim, Ji Won Park, Seung‐Bum Ryoo, Kyu Joo Park, Seung‐Yong Jeong, Jae Hwan Oh. Are sporadic colorectal cancers in young patients distinct from those in elderly patients?. Colorectal Disease 2024; 26(7) doi: 10.1111/codi.17072
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John M. Carethers. The Increasing Incidence of Colorectal Cancers Diagnosed in Subjects Under Age 50 Among Races: CRaCking the Conundrum. Digestive Diseases and Sciences 2016; 61(10) doi: 10.1007/s10620-016-4268-1
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Swati G. Patel, Clement Richard Boland. Colorectal Cancer in Persons Under Age 50. Gastrointestinal Endoscopy Clinics of North America 2020; 30(3) doi: 10.1016/j.giec.2020.03.001
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SW Wong, DY Ling, RQ Yeow, RW Chong, R Aziz, NA Aziz, KS Poh, AC Roslani. Clinicopathological patterns and survival outcomes of colorectal cancer among young adults in Malaysia: an institutional cohort study. Singapore Medical Journal 2021; 62(12) doi: 10.11622/smedj.2021051
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Hadi Feizi, Andrey Plotnikov, Mohammad Ahangarzadeh Rezaee, Khudaverdi Ganbarov, Fadhil S. Kamounah, Sergei Nikitin, Hiva Kadkhoda, Pourya Gholizadeh, Pasquale Pagliano, Hossein Samadi Kafil. Postbiotics versus probiotics in early-onset colorectal cancer. Critical Reviews in Food Science and Nutrition 2024; 64(11) doi: 10.1080/10408398.2022.2132464
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Orla M O'Neill, Helen G Coleman, Helen Reid. Referral challenges for early-onset colorectal cancer: a qualitative study in UK primary care. BJGP Open 2023; 7(4) doi: 10.3399/BJGPO.2023.0123
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Mohamed E. Salem, Francesca Battaglin, Richard M. Goldberg, Alberto Puccini, Anthony F. Shields, David Arguello, W. Michael Korn, John L. Marshall, Axel Grothey, Heinz-Josef Lenz. Molecular Analyses of Left- and Right-Sided Tumors in Adolescents and Young Adults with Colorectal Cancer. The Oncologist 2020; 25(5) doi: 10.1634/theoncologist.2019-0552
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NaNa Keum, Edward Giovannucci. Global burden of colorectal cancer: emerging trends, risk factors and prevention strategies. Nature Reviews Gastroenterology & Hepatology 2019; 16(12) doi: 10.1038/s41575-019-0189-8
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Aung K. Win, Garrett Friedman, Jose G. Guillem. Management of Hereditary Colorectal Cancer. 2020;  doi: 10.1007/978-3-030-26234-1_1
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William Lee, Zishan Wang, Miriam Saffern, Tomi Jun, Kuan-lin Huang. Genomic and molecular features distinguish young adult cancer from later-onset cancer. Cell Reports 2021; 37(7) doi: 10.1016/j.celrep.2021.110005
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Sicheng Zhou, Haipeng Chen, Yujuan Jiang, Jianping Xu, Wei Pei, Jianwei Liang. Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy in Young Patients With Peritoneal Metastasis of Colorectal Cancer—An Asian Experience. Journal of Surgical Research 2023; 281 doi: 10.1016/j.jss.2022.08.018
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A. V. Semyanikhina, A. O. Rasulov, L. N. Lyubchenko. Clinical and genetic aspects of differential diagnostics of hereditary non-polyposis colorectal cancer. Advances in Molecular Oncology 2019; 6(2) doi: 10.17650/2313-805X-2019-6-2-21-27
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Shivani Soni, Pooja Mittal, Jae Ho Lo, Yan Yang, Goar Smbatyan, Keehoon Lee, Junxiang Wan, Hiroshi Kumagai, Kelvin Yen, Hemal H. Mehta, Brendan Miller, Lesly Torres-Gonzalez, Francesca Battaglin, Unnati Hemant Shah, Michela Bartolini, Wu Zhang, David W. Craig, Josh Millstein, Pinchas Cohen, Heinz-Josef Lenz. Age-diet interactions significantly influence intratumoral gene expression, gut microbiome signature and tumor microenvironment in colorectal cancer. Neoplasia 2025; 70 doi: 10.1016/j.neo.2025.101245
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Marzieh Araghi, Isabelle Soerjomataram, Aude Bardot, Jacques Ferlay, Citadel J Cabasag, David S Morrison, Prithwish De, Hanna Tervonen, Paul M Walsh, Oliver Bucher, Gerda Engholm, Christopher Jackson, Carol McClure, Ryan R Woods, Nathalie Saint-Jacques, Eileen Morgan, David Ransom, Vicky Thursfield, Bjørn Møller, Suzanne Leonfellner, Marianne G Guren, Freddie Bray, Melina Arnold. Changes in colorectal cancer incidence in seven high-income countries: a population-based study. The Lancet Gastroenterology & Hepatology 2019; 4(7) doi: 10.1016/S2468-1253(19)30147-5
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Marc Boucher, Gloria Zaffaroni, Gabriela Möslein. Viszeral- und Allgemeinchirurgie. Springer Reference Medizin 2023;  doi: 10.1007/978-3-662-61724-3_79-1
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Deng Tang, Zhigang Mao, Siqi Lan, Yali Song, Si Chen, Yuemei Chen, Mi Su, Yufei Tang, Chengyi Zhu, Ruiting Yan, Ji Zhang, Yufang Wang. Deficient Mismatch Repair Represents a Distinct Molecular Feature of Early‐Onset Colorectal Cancer in Chinese Single‐Center Cohort. International Journal of Cancer 2026;  doi: 10.1002/ijc.70667
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Alberto Puccini, Heinz-Josef Lenz, John L. Marshall, David Arguello, Derek Raghavan, W. Michael Korn, Benjamin A. Weinberg, Kelsey Poorman, Arielle L. Heeke, Philip A. Philip, Anthony F. Shields, Richard M. Goldberg, Mohamed E. Salem. Impact of Patient Age on Molecular Alterations of Left-Sided Colorectal Tumors. The Oncologist 2019; 24(3) doi: 10.1634/theoncologist.2018-0117
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Junwei Tang, Wen Peng, Chuanxing Tian, Yue Zhang, Dongjian Ji, Lu Wang, Kangpeng Jin, Fufeng Wang, Yang Shao, Xiaowei Wang, Yueming Sun. Molecular characteristics of early-onset compared with late-onset colorectal cancer: a case controlled study. International Journal of Surgery 2024; 110(8) doi: 10.1097/JS9.0000000000001584
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Mo Ah Jeong, Hyoun Woo Kang. Early-onset Colorectal Cancer. The Korean Journal of Gastroenterology 2019; 74(1) doi: 10.4166/kjg.2019.74.1.4
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Siti Maryam Ahmad Kendong, Raja Affendi Raja Ali, Khairul Najmi Muhammad Nawawi, Hajar Fauzan Ahmad, Norfilza Mohd Mokhtar. Gut Dysbiosis and Intestinal Barrier Dysfunction: Potential Explanation for Early-Onset Colorectal Cancer. Frontiers in Cellular and Infection Microbiology 2021; 11 doi: 10.3389/fcimb.2021.744606
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Petr Kocián, Ivana Svobodová, Denisa Krejčí, Milan Blaha, Robert Gürlich, Ladislav Dušek, Jiří Hoch, Adam Whitley. Is colorectal cancer a more aggressive disease in young patients? A population-based study from the Czech Republic. Cancer Epidemiology 2019; 63 doi: 10.1016/j.canep.2019.101621
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Jongbeom Shin. Colon Cancer Screening—Is It Necessary to Start under the Age of 50?. Journal of Digestive Cancer Research 2023; 11(3) doi: 10.52927/jdcr.2023.11.3.141
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Richard C. Cabot, Eric S. Rosenberg, Virginia M. Pierce, David M. Dudzinski, Meridale V. Baggett, Dennis C. Sgroi, Jo-Anne O. Shepard, Alyssa Y. Castillo, Emily K. McDonald, Sally H. Ebeling, Helen M. Shields, Fabian J. Scheid, Theodore T. Pierce, Karin L. Andersson, Mark F. Conrad, Martin G. Rosenthal, Scott D. Martin. Case 4-2019: An 18-Year-Old Man with Abdominal Pain and Hematochezia. New England Journal of Medicine 2019; 380(5) doi: 10.1056/NEJMcpc1810391
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Ronald McDowell, Sarah Perrott, Peter Murchie, Christopher Cardwell, Carmel Hughes, Leslie Samuel. Oral antibiotic use and early-onset colorectal cancer: findings from a case-control study using a national clinical database. British Journal of Cancer 2022; 126(6) doi: 10.1038/s41416-021-01665-7
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Swati G Patel, Jordan J Karlitz, Timothy Yen, Christopher H Lieu, C Richard Boland. The rising tide of early-onset colorectal cancer: a comprehensive review of epidemiology, clinical features, biology, risk factors, prevention, and early detection. The Lancet Gastroenterology & Hepatology 2022; 7(3) doi: 10.1016/S2468-1253(21)00426-X
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Rashid N. Lui, Kelvin K.F. Tsoi, Jason M.W. Ho, C.M. Lo, Felix C.H. Chan, Moe H. Kyaw, Joseph J.Y. Sung. Global Increasing Incidence of Young-Onset Colorectal Cancer Across 5 Continents: A Joinpoint Regression Analysis of 1,922,167 Cases. Cancer Epidemiology, Biomarkers & Prevention 2019; 28(8) doi: 10.1158/1055-9965.EPI-18-1111
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Lauren DeDecker, Bretton Coppedge, Julio Avelar-Barragan, William Karnes, Katrine Whiteson. Microbiome distinctions between the CRC carcinogenic pathways. Gut Microbes 2021; 13(1) doi: 10.1080/19490976.2020.1854641
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Suleyman Yasin Goksu, Muhammet Ozer, Syed Mohammad Ali Kazmi, Nina Niu Sanford, Todd A. Aguilera, Chul Ahn, David Hsiehchen, Aravind Sanjeevaiah, Leticia Khosama, Jonathan Bleeker, Muslim Atiq, Muhammad Shaalan Beg. Distinct Clinical Characteristics in Young-Onset Pancreatic Neuroendocrine Tumor. Cancers 2020; 12(9) doi: 10.3390/cancers12092501
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Pooja Dharwadkar, Timothy A. Zaki, Caitlin C. Murphy. Colorectal Cancer in Younger Adults. Hematology/Oncology Clinics of North America 2022; 36(3) doi: 10.1016/j.hoc.2022.02.005
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Kinza Abbas, Sathyaprasad Burjonrappa. Pediatric rectal cancer: Diagnosis and management of a rare problem. Journal of Pediatric Surgery Open 2023; 1 doi: 10.1016/j.yjpso.2023.100014
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Allison Janak, Abhishek Jain, Rolando Garcia-Milian, Oladimeji Aladelokun, Xiaomei Ma, Philip B. Paty, Sajid A. Khan, Caroline H. Johnson. Distinct metabolic and genetic alterations in tumors from early-onset versus late-onset colorectal cancer. Free Radical Biology and Medicine 2025; 240 doi: 10.1016/j.freeradbiomed.2025.08.052
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Ramish Riaz, Nosheen Masood, Arfa Benish. Red flag symptoms: detailed account of clinicopathological features in young-onset colorectal cancer. Intestinal Research 2017; 15(2) doi: 10.5217/ir.2017.15.2.203
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Novel Approaches to Colorectal Cancer. Advances in Cancer Research 2021; 151 doi: 10.1016/bs.acr.2021.03.001
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Elena Savu, Valeriu Șurlin, Liviu Vasile, Ileana Octavia Petrescu, Cristina Elena Singer, Nicolae-Daniel Pirici, Stelian Stefanita Mogoanta. Early-Onset Colorectal Cancer—A Retrospective Study from a Tertiary Referral Hospital in Romania. Diagnostics 2024; 14(10) doi: 10.3390/diagnostics14101052
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Chinock Cheong, Seung Yeop Oh, Young Bae Kim, Kwang Wook Suh, Surinder K. Batra. Differences in biological behaviors between young and elderly patients with colorectal cancer. PLOS ONE 2019; 14(6) doi: 10.1371/journal.pone.0218604
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Maya C. Graves, Janna Z. Andrews. Disparities in Colorectal Cancer Outcomes Among Young Adults and African Americans in the United States. Applied Radiation Oncology 2020;  doi: 10.37549/ARO1258
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Tao Shen, Xianshuo Cheng, Cuifeng Xia, Qiang Li, Yi Gao, Dingguo Pan, Xuan Zhang, Ce Zhang, Yunfeng Li. Erlotinib inhibits colon cancer metastasis through inactivation of TrkB‐dependent ERK signaling pathway. Journal of Cellular Biochemistry 2019; 120(7) doi: 10.1002/jcb.28400
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Qiyang Zhou, Chunxian Zhou, Gang Zhang, Xinyang Xia, Xiaojun Zhou, Jianhua Lang. Age-related differences in adjuvant chemotherapy use and outcomes in stage II colon cancer: a retrospective cohort study. BMC Cancer 2025; 25(1) doi: 10.1186/s12885-025-14848-9
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Kamolyut Lapumnuaypol, Ejaz Mahmood, Wikrom Chaiwatcharayut, Maria V. Bandres, Abhinav Goyal, Djeneba A. Djibo, Andrew Tiu. Colorectal cancer in young African Americans: clinical characteristics and presentations. European Journal of Gastroenterology & Hepatology 2018; 30(10) doi: 10.1097/MEG.0000000000001205
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Hanseul Kim, Marla Lipsyc-Sharf, Xiaoyu Zong, Xiaoyan Wang, Jinhee Hur, Mingyang Song, Molin Wang, Stephanie A. Smith-Warner, Charles Fuchs, Shuji Ogino, Kana Wu, Andrew T. Chan, Yin Cao, Kimmie Ng, Edward L. Giovannucci. Total Vitamin D Intake and Risks of Early-Onset Colorectal Cancer and Precursors. Gastroenterology 2021; 161(4) doi: 10.1053/j.gastro.2021.07.002
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Ji-Yeon Moon, Bong-Hyeon Kye, Seung-Hyun Ko, Ri Na Yoo. Sulfur Metabolism of the Gut Microbiome and Colorectal Cancer: The Threat to the Younger Generation. Nutrients 2023; 15(8) doi: 10.3390/nu15081966
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Abdulrasheed A. Nasir, Patrizia Dall’Igna, Dhruva Ghosh, Christopher B. Weldon. Pediatric Surgical Oncology. 2025;  doi: 10.1007/978-3-031-76882-8_117
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Syed Salman Hamid Hashmi, Ahmed Shady, Jean Atallah-Vinograd, Donelle Cummings, Ashley Maranino, Jennifer Harley. Young-Onset Colon Cancer: A Case Report. Cureus 2022;  doi: 10.7759/cureus.29667
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Cyndy Simonson. Colorectal Cancer – An Update for Primary Care Nurse Practitioners. The Journal for Nurse Practitioners 2018; 14(4) doi: 10.1016/j.nurpra.2017.12.030
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Tao Ye, Ning Zhang, Wenyu Wu, Bing Yang, Jinghui Wang, Wenqi Huang, Dongxin Tang. SNHG14 promotes the tumorigenesis and metastasis of colorectal cancer through miR-32-5p/SKIL axis. In Vitro Cellular & Developmental Biology - Animal 2019; 55(10) doi: 10.1007/s11626-019-00398-5
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Jie Shen, Yiling Wu, Miao Mo, Xiaoshuang Feng, Changming Zhou, Zezhou Wang, Guoxiang Cai, Ying Zheng. Risk Factors Associated With Early-Onset Colorectal Neoplasm in Chinese Youth: A Prospective Population-Based Study. Frontiers in Oncology 2021; 11 doi: 10.3389/fonc.2021.702322
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Daryl Ramai, Jameel Singh, Antonio Facciorusso, Saurabh Chandan, Banreet Dhindsa, Amaninder Dhaliwal, Barbara Galassi, Gianluca Tomasello, Michele Ghidini. Predictors of Lymph Node Metastasis in T1 Colorectal Cancer in Young Patients: Results from a National Cancer Registry. Journal of Clinical Medicine 2021; 10(23) doi: 10.3390/jcm10235511
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Sarah Perrott, Kirsten Laurie, Kirsten Laws, Annie Johnes, Zosia Miedzybrodzka, Leslie Samuel. Young-onset colorectal cancer in the North East of Scotland: survival, clinico-pathological features and genetics. BMC Cancer 2020; 20(1) doi: 10.1186/s12885-020-6606-0
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Atif A Hashmi, Mahnoor Aslam, Khushbakht Rashid, Abrahim H Ali, Tanim Ud Dowlah, Umair Arshad Malik, Shamail Zia, Sunder Sham, Fazail Zia, Muhammad Irfan. Early-Onset/Young-Onset Colorectal Carcinoma: A Comparative Analysis of Morphological Features and Biomarker Profile. Cureus 2023;  doi: 10.7759/cureus.42340
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Hui-Hua Ye, Xue-Juan Mao, Xia-Yan Mao, Jun-Ting Ye, Fang-Fang Lin. Association between lifestyle factors and disease progression in patients with colorectal polyps and early-stage cancer. World Journal of Gastrointestinal Oncology 2025; 17(8): 108452 doi: 10.4251/wjgo.v17.i8.108452
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Andrea A. Hayes-Jordan, Gideon Sandler, Songphol Malakorn, Lian-Chun Xiao, Scott Kopetz, Miguel Rodriquez-Bigas. Colon Cancer in Patients Under 25 Years Old: A Different Disease?. Journal of the American College of Surgeons 2020; 230(4) doi: 10.1016/j.jamcollsurg.2019.12.043
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Begum Dariya, Gayathri Chalikonda, Ganji Purnachandra Nagaraju. Colon Cancer Diagnosis and Therapy. 2021;  doi: 10.1007/978-3-030-63369-1_1
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