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For: Axelrad JE, Roy A, Lawlor G, Korelitz B, Lichtiger S. Thiopurines and inflammatory bowel disease: Current evidence and a historical perspective. World J Gastroenterol 2016; 22(46): 10103-10117 [PMID: 28028358 DOI: 10.3748/wjg.v22.i46.10103]
URL: https://www.wjgnet.com/1007-9327/full/v22/i46/10103.htm
Number Citing Articles
1
Anton Risto, Maie Abdalla, Pär Myrelid. Staging Pouch Surgery in Ulcerative Colitis in the Biological Era. Clinics in Colon and Rectal Surgery 2022; 35(01) doi: 10.1055/s-0041-1740039
2
J.-L. Faucheron, S. Barbois, L. Guttierez, P.-Y. Sage, B. Trilling. Cirugía de las complicaciones anorrectales de la enfermedad de Crohn. EMC - Técnicas Quirúrgicas - Aparato Digestivo 2025; 41(4) doi: 10.1016/S1282-9129(25)51045-0
3
Paula Sousa, Paula Ministro, Alessandro Armuzzi, Axel Dignass, Marte Lie Høivik, Manuel Barreiro-de Acosta, Stephan Vavricka, Rogério Saad-Hossne, Paulo Gustavo Kotze, Laurent Peyrin-Biroulet, Fernando Magro. Thiopurines: Use them or lose them? International survey on current and future use of thiopurines in inflammatory bowel disease. Digestive and Liver Disease 2021; 53(12) doi: 10.1016/j.dld.2021.05.038
4
Anuraag Jena, Chhagan L Birda, Arup Choudhury, Vishal Sharma. Safety and efficacy of personalized versus standard initial dosing of thiopurines: Systematic review and meta-analysis of randomized trials. Expert Opinion on Drug Safety 2023; 22(12) doi: 10.1080/14740338.2023.2236554
5
Qing Zhou, Zhao-Feng Shen, Ben-sheng Wu, Cheng-biao Xu, Zhong-qi He, Tuo Chen, Hong-tao Shang, Chao-fan Xie, Si-yi Huang, Yu-gen Chen, Hai-bo Chen, Shu-tang Han. Risk of Colorectal Cancer in Ulcerative Colitis Patients: A Systematic Review and Meta-Analysis. Gastroenterology Research and Practice 2019; 2019 doi: 10.1155/2019/5363261
6
Ji Young Chang, Jae Hee Cheon. Thiopurine Therapy in Patients With Inflammatory Bowel Disease: A Focus on Metabolism and Pharmacogenetics. Digestive Diseases and Sciences 2019; 64(9) doi: 10.1007/s10620-019-05720-5
7
Dohun Kim, Gerta Hoxhaj. Dynamic control of nucleotide metabolism in physiology and disease. Nature Cell Biology 2026; 28(8) doi: 10.1038/s41556-026-02004-9
8
Margarita L. Martinez-Fierro, Idalia Garza-Veloz, Maria R. Rocha-Pizaña, Edith Cardenas-Vargas, Miguel A. Cid-Baez, Fabiola Trejo-Vazquez, Virginia Flores-Morales, Gabriela A. Villela-Ramirez, Ivan Delgado-Enciso, Iram P. Rodriguez-Sanchez, Yolanda Ortiz-Castro. Serum cytokine, chemokine, and growth factor profiles and their modulation in inflammatory bowel disease. Medicine 2019; 98(38) doi: 10.1097/MD.0000000000017208
9
Katherine R. Baldwin, Jess L. Kaplan. Medical management of pediatric inflammatory bowel disease. Seminars in Pediatric Surgery 2017; 26(6) doi: 10.1053/j.sempedsurg.2017.10.005
10
Johannes Hasskamp, Christian Meinhardt, Petrease H Patton, Antje Timmer. Azathioprine and 6-mercaptopurine for maintenance of remission in ulcerative colitis. Cochrane Database of Systematic Reviews 2025; 2025(2) doi: 10.1002/14651858.CD000478.pub5
11
Erik Munnig-Schmidt, Mei Zhang, Chris J Mulder, Murray L Barclay. Late-onset Rise of 6-MMP Metabolites in IBD Patients on Azathioprine or Mercaptopurine. Inflammatory Bowel Diseases 2018; 24(4) doi: 10.1093/ibd/izx081
12
Karam Devi, Anjana Bali, Pankaj Bhatia, Nirmal Singh, Amteshwar Singh Jaggi. Exploring the ameliorative potential of Bacopa monnieri in acetic acid induced ulcerative colitis in mice . Natural Product Research 2024; 38(12) doi: 10.1080/14786419.2023.2233047
13
Sofía Frigerio, Dalia A. Lartey, Geert R. D’Haens, Joep Grootjans. The Role of the Immune System in IBD-Associated Colorectal Cancer: From Pro to Anti-Tumorigenic Mechanisms. International Journal of Molecular Sciences 2021; 22(23) doi: 10.3390/ijms222312739
14
Teuta Gjuladin-Hellon, Zipporah Iheozor-Ejiofor, Morris Gordon, Anthony K Akobeng. Azathioprine and 6-mercaptopurine for maintenance of surgically-induced remission in Crohn's disease. Cochrane Database of Systematic Reviews 2019; 2019(8) doi: 10.1002/14651858.CD010233.pub3
15
Rasmus Rankala, Anssi Mustonen, Markku Voutilainen, Kalle Mattila. Costs of medications used to treat inflammatory bowel disease. Scandinavian Journal of Gastroenterology 2024; 59(1) doi: 10.1080/00365521.2023.2248539
16
Taku Kobayashi, Eri Udagawa, Toshifumi Hibi. Lack of Increased Risk of Lymphoma with Thiopurine Therapy Regardless of Dose and Duration of Treatment in Japanese Patients with Inflammatory Bowel Diseases. Digestion 2022; 103(2) doi: 10.1159/000519560
17
Caroline Di Jiang, Tim Raine. IBD considerations in spondyloarthritis. Therapeutic Advances in Musculoskeletal Disease 2020; 12 doi: 10.1177/1759720X20939410
18
Carla J. Gargallo-Puyuelo, Viviana Laredo, Fernando Gomollón. Thiopurines in Inflammatory Bowel Disease. How to Optimize Thiopurines in the Biologic Era?. Frontiers in Medicine 2021; 8 doi: 10.3389/fmed.2021.681907
19
Anja Eberl, Taru Hallinen, Clas-Göran af Björkesten, Markku Heikkinen, Eija Hirsi, Mikko Kellokumpu, Inka Koskinen, Veikko Moilanen, Christian Nielsen, Heikki Nuutinen, Ulla-Maija Suhonen, Karri Utriainen, Ilkka Vihriälä, Erkki Soini, Christina Wennerström, Riikka Nissinen, Andras Borsi, Minni Koivunen, Jyrki Tillonen, Taina Sipponen. Ustekinumab for Crohn’s disease: a nationwide real-life cohort study from Finland (FINUSTE). Scandinavian Journal of Gastroenterology 2019; 54(6) doi: 10.1080/00365521.2019.1624817
20
Yong Hua Sheng, Rabina Giri, Julie Davies, Veronika Schreiber, Saleh Alabbas, Ramya Movva, Yaowu He, Andy Wu, John Hooper, Brett McWhinney, Iulia Oancea, Gregor Kijanka, Sumaira Hasnain, Andrew J. Lucke, David P. Fairlie, Michael A. McGuckin, Timothy H. Florin, Jakob Begun. A Nucleotide Analog Prevents Colitis-Associated Cancer via Beta-Catenin Independently of Inflammation and Autophagy. Cellular and Molecular Gastroenterology and Hepatology 2021; 11(1) doi: 10.1016/j.jcmgh.2020.05.012
21
Jack S. Cornish, Elisa Wirthgen, Jan Däbritz. Biomarkers Predictive of Response to Thiopurine Therapy in Inflammatory Bowel Disease. Frontiers in Medicine 2020; 7 doi: 10.3389/fmed.2020.00008
22
Yu Zhou, Fang Shen. Advancements in therapeutic strategies and drug development for inflammatory bowel diseases. Exploration of Immunology 2025; 5 doi: 10.37349/ei.2025.1003232
23
Silvio Danese, Markus F. Neurath, Adam Kopoń, Salam F. Zakko, Timothy C. Simmons, Ronald Fogel, Corey A. Siegel, Remo Panaccione, Xiaojiang Zhan, Keith Usiskin, Denesh Chitkara. Effects of Apremilast, an Oral Inhibitor of Phosphodiesterase 4, in a Randomized Trial of Patients With Active Ulcerative Colitis. Clinical Gastroenterology and Hepatology 2020; 18(11) doi: 10.1016/j.cgh.2019.12.032
24
Dunja Urbančič, Flaka Pasha, Alenka Šmid, Irena Mlinarič-Raščan. Personalization of thiopurine therapy: Current recommendations and future perspectives. Acta Pharmaceutica 2024; 74(3) doi: 10.2478/acph-2024-0030
25
Hongjie Yang, Xianhong Shi, Beibei Wang, Heng Li, Bin Li, Tianqi Zhou, Lulu Tian, Shengjun Wang, Kai Yin. Bile acid receptors regulate the role of intestinal macrophages in inflammatory bowel disease. Frontiers in Immunology 2025; 16 doi: 10.3389/fimmu.2025.1577000
26
Benoit Follin-Arbelet, Milada Cvancarova Småstuen, Øistein Hovde, Lars-Petter Jelsness-Jørgensen, Bjørn Moum. Mortality in Patients with Inflammatory Bowel Disease: Results from 30 Years of Follow-up in a Norwegian Inception Cohort (the IBSEN study). Journal of Crohn's and Colitis 2023; 17(4) doi: 10.1093/ecco-jcc/jjac156
27
Kendra Kamp, Amanda Holmstrom, Zhehui Luo, Gwen Wyatt, Barbara Given. Factors Influencing Received Social Support Among Emerging Adults With Inflammatory Bowel Disease. Gastroenterology Nursing 2020; 43(6) doi: 10.1097/SGA.0000000000000483
28
Giovanni Clemente Actis, Rinaldo Pellicano, Davide Giuseppe Ribaldone. A Concise History of Thiopurines for Inflammatory Bowel Disease: From Anecdotal Reporting to Treat-to-Target Algorithms. Reviews on Recent Clinical Trials 2019; 14(1) doi: 10.2174/1574887113666180910120959
29
Grant E. Barber, Steven Hendler, Monica Choe, Kian Keyashian, Sarah Lechner, Berkeley N. Limketkai, David Limsui. Thiopurine Monotherapy Is Effective in Maintenance of Mild-Moderate Inflammatory Bowel Disease. Digestive Diseases and Sciences 2022; 67(4) doi: 10.1007/s10620-021-06947-x
30
Stefano Mazza, Sara Soro, Maria Chiara Verga, Biagio Elvo, Francesca Ferretti, Fabrizio Cereatti, Andrea Drago, Roberto Grassia. Liver-side of inflammatory bowel diseases: Hepatobiliary and drug-induced disorders. World Journal of Hepatology 2021; 13(12): 1828-1849 doi: 10.4254/wjh.v13.i12.1828
31
J.-L. Faucheron, S. Barbois, L. Guttierez, P.-Y. Sage, B. Trilling. Chirurgie des complications anorectales de la maladie de Crohn. EMC - Techniques chirurgicales - Appareil digestif 2025; 42(3) doi: 10.1016/S0246-0424(24)48137-5
32
Christopher J Burgess, Claire Reilly, Lana Steward-Harrison, Fariha Balouch, Peter J Lewindon. Utility of proactive infliximab levels in paediatric Crohn’s disease. Archives of Disease in Childhood 2019; 104(3) doi: 10.1136/archdischild-2018-315100
33
Michael W. Winter, Joel V. Weinstock. The Autoimmune Diseases. 2020;  doi: 10.1016/B978-0-12-812102-3.00046-4
34
Jorge Sáez-Leyva, Matthew P. Lennol, Carlos Avilés-Granados, María-Salud García-Ayllón, Javier Sáez-Valero. Risk for COVID-19 Vulnerability in Patients with Inflammatory Bowel Disease: Assessing Alterations in ACE2 and TMPRSS2. Biomedicines 2025; 13(9) doi: 10.3390/biomedicines13092240
35
Abdullah Alotaibi, Abrar Alhubayshi, Abed Allehibi, Abdullah Almtawa, Nawaf Alotaibi, Adel Alghamdi, Saad Alrajhi, Adel Alqutub, Ahmad Aleid, Abdulrhman Alamr, Bashaar Ibrahim, Mohammed Alahmari, Hussam Alhamidi, Shameem Ahmad, Hadeel AlBayyat, Osama Alshaya, Youssef Altannir, Ahmed Alghamdi. Prevalence of Classical Extraintestinal Manifestations among Inflammatory Bowel Disease Patients in Saudi Arabia: A Single Tertiary Center Experience. Saudi Journal of Medicine & Medical Sciences 2024; 12(2) doi: 10.4103/sjmms.sjmms_139_23
36
Ewa Dudzińska, Magdalena Gryzinska, Katarzyna Ognik, Paulina Gil-Kulik, Janusz Kocki, Vladimir Jakovljevic. Oxidative Stress and Effect of Treatment on the Oxidation Product Decomposition Processes in IBD. Oxidative Medicine and Cellular Longevity 2018; 2018(1) doi: 10.1155/2018/7918261
37
Marcel Vetter, Markus F. Neurath. Treatment Perspectives in Crohn’s Disease. Digestion 2018; 98(3) doi: 10.1159/000488449
38
Sydney Solomon, Eunie Park, Joseph A. Picoraro. Making Decisions about Dietary Therapy in Inflammatory Bowel Disease. Gastrointestinal Disorders 2020; 2(4) doi: 10.3390/gidisord2040032
39
Gonzalo Saiz-Gonzalo, Naomi Hanrahan, Valerio Rossini, Raminder Singh, Mary Ahern, Maebh Kelleher, Shane Hill, Ruairi O’Sullivan, Aine Fanning, Patrick T. Walsh, Seamus Hussey, Fergus Shanahan, Ken Nally, Caitriona M. O’Driscoll, Silvia Melgar. Regulation of CEACAM Family Members by IBD-Associated Triggers in Intestinal Epithelial Cells, Their Correlation to Inflammation and Relevance to IBD Pathogenesis. Frontiers in Immunology 2021; 12 doi: 10.3389/fimmu.2021.655960
40
Rachel Rutherford, Patrick B Allen. New and Old Therapeutic Options for Luminal Crohn's Disease - An Overview of Current Literature. OBM Hepatology and Gastroenterology 2019; 3(03) doi: 10.21926/obm.hg.1903031
41
Shailesh Perdalkar, Pooja Basthi Mohan, Balaji Musunuri, Siddheesh Rajpurohit, Shiran Shetty, Krishnamurthy Bhat, Cannanore Ganesh Pai. Thiopurine therapy in inflammatory bowel disease in the pandemic era: Safe or unsafe?. International Immunopharmacology 2023; 116 doi: 10.1016/j.intimp.2022.109597
42
Natália Oliveira e Silva, Breno Bittencourt de Brito, Filipe Antônio França da Silva, Maria Luísa Cordeiro Santos, Fabrício Freire de Melo. Probiotics in inflammatory bowel disease: Does it work?. World Journal of Meta-Analysis 2020; 8(2): 54-66 doi: 10.13105/wjma.v8.i2.54
43
Armando Curto, Erica Nicola Lynch, Michele Tanturli, Rocco Gabriele Iamello, Marco Vanni, Enzo Monaco, Tommaso Mello, Tommaso Innocenti, Gabriele Dragoni, Andrea Galli. Porto-sinusoidal vascular disorder and sinusoidal obstructive syndrome in patients treated with thiopurines: a systematic review. Annals of Hepatology 2026;  doi: 10.1016/j.aohep.2026.102439
44
Maria Francesca Russo, Annalisa Diddoro, Alessandra Iodice, Carola Severi, Lidia Castagneto-Gissey, Giovanni Casella. Incidence of lymphomas in inflammatory bowel disease: report of an emblematic case, systematic review, and meta-analysis. Frontiers in Medicine 2023; 10 doi: 10.3389/fmed.2023.1172634
45
Mireya Ramirez-Florencio, Silvia Jiménez-Morales, Rosa Elda Barbosa-Cobos, Daniela Josabeth López-Cano, Julian Ramírez-Bello. High frequency of mutant thiopurine S-methyltransferase genotypes in Mexican patients with systemic lupus erythematosus and rheumatoid arthritis. Clinical Rheumatology 2018; 37(4) doi: 10.1007/s10067-017-3955-4
46
Rachid El Jim, Chaimae Maroute, Maria Lahlali, Asmae Lamine Séjai, Hakima Abid, Nada Lahmidani, Amine El Mekkaoui, El Yousfi Mounia, Dafr-Allah Bennajeh, Sidi Adil Ibrahimi, Mohamed El Abkari. Safety Profile of Azathioprine in Inflammatory Bowel Disease. Open Journal of Gastroenterology 2025; 15(08) doi: 10.4236/ojgas.2025.158039
47
Takahiro Ito, Atsuo Maemoto, Takehiko Katsurada, Hiroki Tanaka, Satoshi Motoya, Nobuhiro Ueno, Mikihiro Fujiya, Toshifumi Ashida, Daisuke Hirayama, Hiroshi Nakase. Long-Term Clinical Effectiveness of Ustekinumab in Patients With Crohn’s Disease: A Retrospective Cohort Study. Crohn's & Colitis 360 2020; 2(4) doi: 10.1093/crocol/otaa061
48
Taina Sipponen, Clas-Göran af Björkesten, Taru Hallinen, Tuire Ilus, Erkki Soini, Anja Eberl, Mikko Heikura, Mikko Kellokumpu, Ritva Koskela, Christian Nielsen, Heikki Nuutinen, Markku Heikkinen, Ulla-Maija Suhonen, Jyrki Tillonen, E. Christina M. Wennerström, Andras Borsi, Minni R. Koivunen. A nationwide real-world study on dynamic ustekinumab dosing and concomitant medication use among Crohn’s disease patients in Finland. Scandinavian Journal of Gastroenterology 2021; 56(6) doi: 10.1080/00365521.2021.1906315
49
J.-L. Faucheron, S. Barbois, L. Guttierez, P.-Y. Salvia, B. Trilling. Chirurgia per le complicanze ano-rettali della malattia di Crohn. EMC - Tecniche Chirurgiche Addominale 2025; 31(4) doi: 10.1016/S1283-0798(25)51138-5
50
Jason Reinglas, Lorant Gonczi, Zsuzsanna Kurt, Talat Bessissow, Peter L Lakatos. Positioning of old and new biologicals and small molecules in the treatment of inflammatory bowel diseases. World Journal of Gastroenterology 2018; 24(32): 3567-3582 doi: 10.3748/wjg.v24.i32.3567