For: | Sipos F, Firneisz G, Műzes G. Therapeutic aspects of c-MYC signaling in inflammatory and cancerous colonic diseases. World J Gastroenterol 2016; 22(35): 7938-7950 [PMID: 27672289 DOI: 10.3748/wjg.v22.i35.7938] |
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URL: | https://www.wjgnet.com/1007-9327/full/v22/i35/7938.htm |
Number | Citing Articles |
1 |
Su Yeon Lee, Min Kyung Ju, Hyun Min Jeon, Eui Kyong Jeong, Yig Ji Lee, Cho Hee Kim, Hye Gyeong Park, Song Iy Han, Ho Sung Kang, Rodrigo Franco. Regulation of Tumor Progression by Programmed Necrosis. Oxidative Medicine and Cellular Longevity 2018; 2018(1) doi: 10.1155/2018/3537471
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2 |
Beibei Liu, Wuyue Gao, Wei Sun, Liqiang Li, Chao Wang, Xiaohuai Yang, Jianmin Liu, Yuanyuan Guo. Promoting roles of long non-coding RNA FAM83H-AS1 in bladder cancer growth, metastasis, and angiogenesis through the c-Myc-mediated ULK3 upregulation. Cell Cycle 2020; 19(24): 3546 doi: 10.1080/15384101.2020.1850971
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3 |
Yi‐Feng Zheng, Jie Luo, Guo‐Lian Gan, Wei Li. Overexpression of microRNA‐98 inhibits cell proliferation and promotes cell apoptosis via claudin‐1 in human colorectal carcinoma. Journal of Cellular Biochemistry 2019; 120(4): 6090 doi: 10.1002/jcb.27895
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4 |
Haiqiong Ye, Yujiao Zhang, Yongzhou Wang, Jiyi Xia, Xiguang Mao, Xiaolan Yu. The restraining effect of baicalein and U0126 on human cervical cancer cell line HeLa. Molecular Medicine Reports 2017; 16(1): 957 doi: 10.3892/mmr.2017.6648
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5 |
Zhaoxiu Liu, Chengqi Guan, Cuihua Lu, Yanmei Liu, Runzhou Ni, Mingbing Xiao, Zhaolian Bian. High NUSAP1 expression predicts poor prognosis in colon cancer. Pathology - Research and Practice 2018; 214(7): 968 doi: 10.1016/j.prp.2018.05.017
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6 |
Ji Eon Park, Ji Hoon Jung, Hyo‐Jung Lee, Deok Yong Sim, Eunji Im, Woon Yi Park, Bum Sang Shim, Seong‐Gyu Ko, Sung‐Hoon Kim. Ribosomal protein L5 mediated inhibition of c‐Myc is critically involved in sanggenon G induced apoptosis in non‐small lung cancer cells. Phytotherapy Research 2021; 35(2): 1080 doi: 10.1002/ptr.6878
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7 |
Mengjia Huang, Yuqing Ye, Yi Chen, Junkai Zhu, Li Xu, Wenxuan Cheng, Xiaofan Lu, Fangrong Yan. Identification and validation of an inflammation-related lncRNAs signature for improving outcomes of patients in colorectal cancer. Frontiers in Genetics 2022; 13 doi: 10.3389/fgene.2022.955240
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8 |
Yi Zhang, Yina Shao, Zhimeng Lv, Weiwei Zhang, Xuelin Zhao, Ming Guo, Chenghua Li. Molecular cloning and functional characterization of MYC transcription factor in pathogen-challenged Apostichopus japonicus. Developmental & Comparative Immunology 2020; 102: 103487 doi: 10.1016/j.dci.2019.103487
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9 |
Yujiro Nishizawa, Masamitsu Konno, Ayumu Asai, Jun Koseki, Koichi Kawamoto, Norikatsu Miyoshi, Hidekazu Takahashi, Naohiro Nishida, Naotsugu Haraguchi, Daisuke Sakai, Toshihiro Kudo, Taishi Hata, Chu Matsuda, Tsunekazu Mizushima, Taroh Satoh, Yuichiro Doki, Masaki Mori, Hideshi Ishii. Oncogene c-Myc promotes epitranscriptome m6A reader YTHDF1 expression in colorectal cancer. Oncotarget 2018; 9(7): 7476 doi: 10.18632/oncotarget.23554
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10 |
Laura Vízkeleti, Sándor Spisák. Rewired Metabolism Caused by the Oncogenic Deregulation of MYC as an Attractive Therapeutic Target in Cancers. Cells 2023; 12(13): 1745 doi: 10.3390/cells12131745
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11 |
Raul Carpi-Santos, Ricardo A. de Melo Reis, Flávia Carvalho Alcantara Gomes, Karin C. Calaza. Contribution of Müller Cells in the Diabetic Retinopathy Development: Focus on Oxidative Stress and Inflammation. Antioxidants 2022; 11(4): 617 doi: 10.3390/antiox11040617
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12 |
Srijayaprakash Babu Uppada, Saiprasad Gowrikumar, Rizwan Ahmad, Balawant Kumar, Bryan Szeglin, Xi Chen, J. Joshua Smith, Surinder K. Batra, Amar B. Singh, Punita Dhawan. MASTL induces Colon Cancer progression and Chemoresistance by promoting Wnt/β-catenin signaling. Molecular Cancer 2018; 17(1) doi: 10.1186/s12943-018-0848-3
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13 |
Yanping Jin, Jianping Qiu, Xiufang Lu, Guowei Li. C-MYC Inhibited Ferroptosis and Promoted Immune Evasion in Ovarian Cancer Cells through NCOA4 Mediated Ferritin Autophagy. Cells 2022; 11(24): 4127 doi: 10.3390/cells11244127
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14 |
Ji Tae Kim, Chang Li, Heidi L. Weiss, Yuning Zhou, Chunming Liu, Qingding Wang, B. Mark Evers. Regulation of Ketogenic Enzyme HMGCS2 by Wnt/β-catenin/PPARγ Pathway in Intestinal Cells. Cells 2019; 8(9): 1106 doi: 10.3390/cells8091106
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15 |
Chang Xu, Xiaonan Wang, Wenjing Li, Kun Wang, Lei Ding. Expression and Clinical Significance of Claudin-7 in Patients With Colorectal Cancer. Technology in Cancer Research & Treatment 2018; 17 doi: 10.1177/1533033818817774
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16 |
Stephen M. Matthews, Melanie A. Eshelman, Arthur S. Berg, Walter A. Koltun, Gregory S. Yochum, Hodaka Fujii. The Crohn’s disease associated SNP rs6651252 impacts MYC gene expression in human colonic epithelial cells. PLOS ONE 2019; 14(2): e0212850 doi: 10.1371/journal.pone.0212850
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17 |
Wandi Cao, Mingkang Liu, Canyang Wang, Guoxing Jing, Yi Cao. Influences of repeated exposure to low levels of TiO2 nanoparticles on Kruppel‐like factors in 3D Caco‐2 spheroids and mouse intestines. Journal of Applied Toxicology 2023; 43(5): 706 doi: 10.1002/jat.4420
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18 |
Jiayu Zhang, Chengwei Chen, Liang Wu, Qiang Wang, Jiawei Chen, Sifang Zhang, Zhenguo Chen. C-myc contributes to the release of Müller cells-derived proinflammatory cytokines by regulating lncRNA MIAT/XNIP pathway. The International Journal of Biochemistry & Cell Biology 2019; 114: 105574 doi: 10.1016/j.biocel.2019.105574
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19 |
Barira Islam, John Stephenson, Bethan Young, Maurizio Manca, David A. Buckley, Helen Radford, Panagiotis Zis, Mark I. Johnson, David P. Finn, Patrick C. McHugh. The Identification of Blood Biomarkers of Chronic Neuropathic Pain by Comparative Transcriptomics. NeuroMolecular Medicine 2022; 24(3): 320 doi: 10.1007/s12017-021-08694-8
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20 |
Li Tan, Nan Lei, Man He, Meng Zhang, Qiang Sun, Sha Zeng, Li Chen, Lijuan Zhou, Xianli Meng, Haibo Xu. Scutellarin Protects against Human Colorectal Cancer in vitro by Down Regulation of Hedgehog Signaling Pathway Activity. International Journal of Pharmacology 2019; 16(1): 53 doi: 10.3923/ijp.2020.53.62
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21 |
Yinzi Yue, Lianlin Su, Yahui Wang, Xiaoman Li, Xiaoyan Xiao, Jin Xie, Shuai Yan. Banxia Xiexin Decoction inhibits colitis-associated colorectal cancer development by modulating STAT3 signaling and gut microbiota. Chinese Herbal Medicines 2024; doi: 10.1016/j.chmed.2024.02.004
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22 |
Sarah K. Madden, Aline Dantas de Araujo, Mara Gerhardt, David P. Fairlie, Jody M. Mason. Taking the Myc out of cancer: toward therapeutic strategies to directly inhibit c-Myc. Molecular Cancer 2021; 20(1) doi: 10.1186/s12943-020-01291-6
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23 |
Bruna Cristina dos Santos Cruz, Vinícius da Silva Duarte, Roberto Sousa Dias, Andressa Ladeira Bernardes, Sérgio Oliveira de Paula, Célia Lúcia de Luces Fortes Ferreira, Maria do Carmo Gouveia Peluzio. Synbiotic modulates intestinal microbiota metabolic pathways and inhibits DMH-induced colon tumorigenesis through c-myc and PCNA suppression. Food Research International 2022; 158: 111379 doi: 10.1016/j.foodres.2022.111379
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24 |
Qing Huang, Chunlan Pu, Lun Tan, Shirui Wang, Hongjia Zhang, Su Yu, Rui Deng, Dan Luo, Xinyu Ma, Rui Li. Synthesis and biological evaluation of a novel c-Myc inhibitor against colorectal cancer via blocking c-Myc/Max heterodimerization and disturbing its DNA binding. European Journal of Medicinal Chemistry 2022; 243: 114779 doi: 10.1016/j.ejmech.2022.114779
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25 |
Caiyun Long, Yunxia Xiao, Siying Li, Xiaobing Tang, Zhengwei Yuan, Yuzuo Bai. Involvement of proliferative and apoptotic factors in the development of hindgut in rat fetuses with ethylenethiourea-induced anorectal malformations. Acta Histochemica 2020; 122(1): 151466 doi: 10.1016/j.acthis.2019.151466
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26 |
Weizhen Huang, Yunming Tian, Shaoting Dong, Yinlian Cha, Jun Li, Xiaohong Guo, Xia Yuan. The long non-coding RNA SNHG3 functions as a competing endogenous RNA to promote malignant development of colorectal cancer. Oncology Reports 2017; 38(3): 1402 doi: 10.3892/or.2017.5837
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27 |
Nissim Ohana, Daniel Benharroch, Dimitri Sheinis, Abraham Cohen. Traumatic glioblastoma: commentary and suggested mechanism. Journal of International Medical Research 2018; 46(6): 2170 doi: 10.1177/0300060518771265
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28 |
Yue Qi, Mirza M. F. Qadir, Araceli A. Hastreiter, Ricardo A. Fock, Jacqueline F. Machi, Alejo A. Morales, Ying Wang, Zhipeng Meng, Claudia O. Rodrigues. Endothelial c‐Myc knockout enhances diet‐induced liver inflammation and fibrosis. The FASEB Journal 2022; 36(1) doi: 10.1096/fj.202101086R
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29 |
Hussein Anani, Iman Baluchi, Alireza Farsinejad, Ahmad Fatemi, Roohollah Mirzaee Khalilabadi. Zataria multiflora methanolic extract has antitumor properties on U266 multiple myeloma cell line. Gene Reports 2020; 20: 100655 doi: 10.1016/j.genrep.2020.100655
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30 |
I.А. Hromakova, P.P. Sorochan, N.E. Prokhach, I.S. Hromakova. Interleukin-6 and colorectal cancer development. Український радіологічний та онкологічний журнал 2021; 29(4): 89 doi: 10.46879/ukroj.4.2021.89-107
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31 |
Haris Saeed, Brian J. Leibowitz, Lin Zhang, Jian Yu. Targeting Myc-driven stress addiction in colorectal cancer. Drug Resistance Updates 2023; 69: 100963 doi: 10.1016/j.drup.2023.100963
|
32 |
Linglin Tian, Yuan Li, Ruqi Chang, Peng Zhang, Jian Zhang, Lijuan Huo. Lentiviral vector‑mediated IL‑9 overexpression stimulates cell proliferation by targeting c‑myc and cyclin D1 in colitis‑associated cancer. Oncology Letters 2018; doi: 10.3892/ol.2018.9567
|
33 |
Dong Kim, Jehyun Nam, Matthew Cha, Sang‑Woo Kim. Inhibition of phosphodiesterase 4D decreases the malignant properties of DLD‑1 colorectal cancer cells by repressing the AKT/mTOR/Myc signaling pathway. Oncology Letters 2019; doi: 10.3892/ol.2019.9996
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34 |
Wei Han, Jia Shi, Jiachao Cao, Bo Dong, Wei Guan. <p>Emerging Roles and Therapeutic Interventions of Aerobic Glycolysis in Glioma</p>. OncoTargets and Therapy 2020; : 6937 doi: 10.2147/OTT.S260376
|
35 |
Ji He, Jiayu Fu, Dongsheng Fan. The complement C7 variant rs3792646 is associated with amyotrophic lateral sclerosis in a Han Chinese population. Neurobiology of Aging 2021; 99: 103.e1 doi: 10.1016/j.neurobiolaging.2020.10.012
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36 |
Magdalena Owczarz, Jacek Połosak, Anna Domaszewska-Szostek, Paulina Kołodziej, Alina Kuryłowicz, Monika Puzianowska-Kuźnicka. Age-related epigenetic drift deregulates SIRT6 expression and affects its downstream genes in human peripheral blood mononuclear cells. Epigenetics 2020; 15(12): 1336 doi: 10.1080/15592294.2020.1780081
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37 |
Xing Wang, Jiandi Yu, Junfeng Yan, Kun Peng, Haiyong Zhou. Single-cell sequencing reveals MYC targeting gene MAD2L1 is associated with prostate cancer bone metastasis tumor dormancy. BMC Urology 2022; 22(1) doi: 10.1186/s12894-022-00991-z
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38 |
Ferenc Sipos, Györgyi Műzes. Sirtuins Affect Cancer Stem Cells via Epigenetic Regulation of Autophagy. Biomedicines 2024; 12(2): 386 doi: 10.3390/biomedicines12020386
|
39 |
Liqun Yang, Qian Lei, Lin Li, Jie Yang, Zhen Dong, Hongjuan Cui. Silencing or inhibition of H3K79 methyltransferase DOT1L induces cell cycle arrest by epigenetically modulating c-Myc expression in colorectal cancer. Clinical Epigenetics 2019; 11(1) doi: 10.1186/s13148-019-0778-y
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40 |
Eun Kyung Choe, Sangwoo Lee, So Yeon Kim, Manu Shivakumar, Kyu Joo Park, Young Jun Chai, Dokyoon Kim. Prognostic Effect of Inflammatory Genes on Stage I–III Colorectal Cancer—Integrative Analysis of TCGA Data. Cancers 2021; 13(4): 751 doi: 10.3390/cancers13040751
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41 |
You‑Sheng Huang, Na Jie, Yi‑Xin Zhang, Ke‑Jian Zou, Yang Weng. shRNA-induced silencing of Ras-related C3 botulinum toxin substrate 1 inhibits the proliferation of colon cancer cells through upregulation of BAD and downregulation of cyclin D1. International Journal of Molecular Medicine 2017; doi: 10.3892/ijmm.2017.3345
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42 |
Asif A. Dar, Dale D. Kim, Scott M. Gordon, Kathleen Klinzing, Siera Rosen, Ipsita Guha, Nadia Porter, Yohaniz Ortega, Katherine S. Forsyth, Jennifer Roof, Hossein Fazelinia, Lynn A. Spruce, Laurence C. Eisenlohr, Edward M. Behrens, Paula M. Oliver. c-Myc uses Cul4b to preserve genome integrity and promote antiviral CD8+ T cell immunity. Nature Communications 2023; 14(1) doi: 10.1038/s41467-023-42765-7
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43 |
Ji Hoon Jung, Hyemin Lee, Ju-Ha Kim, Deok Yong Sim, Hyojin Ahn, Bonglee Kim, Suhwan Chang, Sung-Hoon Kim. p53-Dependent Apoptotic Effect of Puromycin via Binding of Ribosomal Protein L5 and L11 to MDM2 and Its Combination Effect with RITA or Doxorubicin. Cancers 2019; 11(4): 582 doi: 10.3390/cancers11040582
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44 |
Wei Duan, Yu Chen, Jinlu Shan, Qian Li. Targeted Regulation of Osteoblasts and Osteoclasts in Osteosarcoma Patients
by CSF3R Receptor Inhibition of Osteolysis Caused by Tumor Inflammation
Based on Transcriptional Spectrum Analysis and Drug Library Screening. Recent Patents on Anti-Cancer Drug Discovery 2024; 19(5): 635 doi: 10.2174/0115748928259095231010055507
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45 |
Wei Li, Ning Zhang, Caining Jin, Mark D. Long, Hasan Rajabi, Yota Yasumizu, Atsushi Fushimi, Nami Yamashita, Masayuki Hagiwara, Rongbin Zheng, Jin Wang, Ling Kui, Harpal Singh, Surender Kharbanda, Qiang Hu, Song Liu, Donald Kufe. MUC1-C drives stemness in progression of colitis to colorectal cancer. JCI Insight 2020; 5(12) doi: 10.1172/jci.insight.137112
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46 |
Guanyi Liu, Dingyang Li, Liwei Zhang, Qiuping Xu, Dexuan Zhuang, Panpan Liu, Ling Hu, Huiting Deng, Jianfeng Sun, Shuangshuang Wang, Bin Zheng, Jing Guo, Xunwei Wu. Phenformin Down-Regulates c-Myc Expression to Suppress the Expression of Pro-Inflammatory Cytokines in Keratinocytes. Cells 2022; 11(15): 2429 doi: 10.3390/cells11152429
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47 |
Ka Iong Chan, Siyuan Zhang, Guodong Li, Yida Xu, Liao Cui, Yitao Wang, Huanxing Su, Wen Tan, Zhangfeng Zhong. MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products. Aging and disease 2024; 15(2): 640 doi: 10.14336/AD.2023.0520
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48 |
Zhe Zhang, Kui Li, Zhi Zheng, Yu Liu. Cordycepin inhibits colon cancer proliferation by suppressing MYC expression. BMC Pharmacology and Toxicology 2022; 23(1) doi: 10.1186/s40360-022-00551-z
|
49 |
Xiaoli Yang, Ning Cao, Lu Chen, Lin Liu, Min Zhang, Ying Cao. Suppression of Cell Tumorigenicity by Non-neural Pro-differentiation Factors via Inhibition of Neural Property in Tumorigenic Cells. Frontiers in Cell and Developmental Biology 2021; 9 doi: 10.3389/fcell.2021.714383
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50 |
Yucheng Fu, Guoyu He, Zhuochao Liu, Jun Wang, Zhusheng Zhang, Qiyuan Bao, Junxiang Wen, Zhijian Jin, Weibin Zhang. Exploration and Validation of a Novel Inflammatory Response-Associated Gene Signature to Predict Osteosarcoma Prognosis and Immune Infiltration. Journal of Inflammation Research 2021; : 6719 doi: 10.2147/JIR.S340477
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51 |
Kaiming Wu, Kaiwu Xu, Kuanzhi Liu, Jiehong Huang, Jianhui Chen, Jian Zhang, Ning Zhang. Long noncoding RNA BC200 regulates cell growth and invasion in colon cancer. The International Journal of Biochemistry & Cell Biology 2018; 99: 219 doi: 10.1016/j.biocel.2018.04.001
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52 |
Li Guowei, Lu Xiufang, Xu Qianqian, Jin Yanping. The FDX1 methylation regulatory mechanism in the malignant phenotype of glioma. Genomics 2023; 115(2): 110601 doi: 10.1016/j.ygeno.2023.110601
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53 |
María Arredondo-Amador, Raquel González, Carlos J. Aranda, Olga Martínez-Augustin, Fermín Sánchez de Medina. Mice carrying an epithelial deletion of the glucocorticoid receptor NR3C1 develop a higher tumor load in experimental colitis-associated cancer. American Journal of Physiology-Gastrointestinal and Liver Physiology 2021; 321(6): G705 doi: 10.1152/ajpgi.00384.2020
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54 |
Shreya Das, Nidhi Shukla, Shashi Shekhar Singh, Sapana Kushwaha, Richa Shrivastava. Mechanism of interaction between autophagy and apoptosis in cancer. Apoptosis 2021; 26(9-10): 512 doi: 10.1007/s10495-021-01687-9
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55 |
Wenyang Yu, Cuiping Liu, Xin Li, Fuguo Yang, Lixue Cheng, Chang Liu, Yang Song. Inositol hexaphosphate suppresses colorectal cancer cell proliferation via the Akt/GSK-3β/β-catenin signaling cascade in a 1,2-dimethylhydrazine-induced rat model. European Journal of Pharmacology 2017; 805: 67 doi: 10.1016/j.ejphar.2017.03.011
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56 |
Qiang Yu, Jiajun Ding, Shisen Li, Yunlong Li. Autophagy in cancer immunotherapy: Perspective on immune evasion and cell death interactions. Cancer Letters 2024; 590: 216856 doi: 10.1016/j.canlet.2024.216856
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57 |
Jian Wang, Zhenyu Li, Hong Mei, Dejun Zhang, Gang Wu, Tao Zhang, Zhenyu Lin. Antitumor effects of a covalent cyclin-dependent kinase 7 inhibitor in colorectal cancer. Anti-Cancer Drugs 2019; 30(5): 466 doi: 10.1097/CAD.0000000000000749
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58 |
Huawei Zeng, Bryan D. Safratowich, Thomas T. Y. Wang, Stephanie K. Hamlin, LuAnn K. Johnson. Butyrate Inhibits Deoxycholic‐Acid‐Resistant Colonic Cell Proliferation via Cell Cycle Arrest and Apoptosis: A Potential Pathway Linking Dietary Fiber to Cancer Prevention. Molecular Nutrition & Food Research 2020; 64(8) doi: 10.1002/mnfr.201901014
|
59 |
Paul Holvoet. Noncoding RNAs Controlling Oxidative Stress in Cancer. Cancers 2023; 15(4): 1155 doi: 10.3390/cancers15041155
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60 |
Xuejing Yang, Bin Lu, Xueqin Sun, Cuijuan Han, Chunling Fu, Kailin Xu, Min Wang, Dengju Li, Zhichao Chen, Puneet Opal, Qiang Wen, John D. Crispino, Qian-fei Wang, Zan Huang. ANP32A regulates histone H3 acetylation and promotes leukemogenesis. Leukemia 2018; 32(7): 1587 doi: 10.1038/s41375-018-0010-7
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61 |
Oleg I. Kit, Dmitry I. Vodolazhsky, Denis S. Kutilin, Yaroslav S. Enin, Yury A. Gevorkyan, Peter V. Zolotukhin, Yanis Boumber, Leonid V. Kharin, Svetlana B. Panina. A Proteomics Analysis Reveals 9 Up-Regulated Proteins Associated with Altered Cell Signaling in Colon Cancer Patients. The Protein Journal 2017; 36(6): 513 doi: 10.1007/s10930-017-9746-6
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62 |
Vetriselvan Subramaniyan, Shivkanya Fuloria, Gaurav Gupta, Darnal Hari Kumar, Mahendran Sekar, Kathiresan V. Sathasivam, Kalvatala Sudhakar, Khalid Saad Alharbi, Waleed Hassan Al-Malki, Obaid Afzal, Imran Kazmi, Fahad A. Al-Abbasi, Abdulmalik Saleh Alfawaz Altamimi, Neeraj Kumar Fuloria. A review on epidermal growth factor receptor's role in breast and non-small cell lung cancer. Chemico-Biological Interactions 2022; 351: 109735 doi: 10.1016/j.cbi.2021.109735
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63 |
Tao Wang, Dao-Rui Yu, Jing Huang, Qiang Liu, Dan-Xin Wang, Nan Luo, Hao Jia, Hao-Fei Fan, Qi-Bing Liu. Multimodal Rehabilitation Program Promotes Motor Function Recovery of Rats After Ischemic Stroke by Upregulating Expressions of GAP-43, SYN, HSP70, and C-MYC. Journal of Stroke and Cerebrovascular Diseases 2018; 27(10): 2829 doi: 10.1016/j.jstrokecerebrovasdis.2018.06.018
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64 |
Nazma Shaheen, Afiatul Azam, Amlan Ganguly, Saeed Anwar, Md. Sorwer Alam Parvez, Ujwal Punyamurtula, Md. Kamrul Hasan. Anti-inflammatory and analgesic activities of black cumin (BC, Nigella sativa L.) extracts in in vivo model systems. Bulletin of the National Research Centre 2022; 46(1) doi: 10.1186/s42269-022-00708-0
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