BPG is committed to discovery and dissemination of knowledge
Cited by in CrossRef
For: Zhu WQ, Wang J, Guo XF, Liu Z, Dong WG. Thymoquinone inhibits proliferation in gastric cancer via the STAT3 pathway in vivo and in vitro. World J Gastroenterol 2016; 22(16): 4149-4159 [PMID: 27122665 DOI: 10.3748/wjg.v22.i16.4149]
URL: https://www.wjgnet.com/1007-9327/full/v22/i16/4149.htm
Number Citing Articles
1
Yasmina K. Mahmoud, Heba M.A. Abdelrazek. Cancer: Thymoquinone antioxidant/pro-oxidant effect as potential anticancer remedy. Biomedicine & Pharmacotherapy 2019; 115 doi: 10.1016/j.biopha.2019.108783
2
Mohammed M Mehanna, Rana Sarieddine, Jana K Alwattar, Racha Chouaib, Hala Gali-Muhtasib. <p>Anticancer Activity of Thymoquinone Cubic Phase Nanoparticles Against Human Breast Cancer: Formulation, Cytotoxicity and Subcellular Localization</p>. International Journal of Nanomedicine 2020;  doi: 10.2147/IJN.S263797
3
Saleh A. Almatroodi, Ahmad Almatroudi, Mohammed A. Alsahli, Amjad A. Khan, Arshad H. Rahmani. Thymoquinone, an Active Compound of Nigella sativa: Role in Prevention and Treatment of Cancer. Current Pharmaceutical Biotechnology 2020; 21(11) doi: 10.2174/1389201021666200416092743
4
Shahid Karim, Abdulhadi S. Burzangi, Aftab Ahmad, Nasir Ali Siddiqui, Ibrahim M. Ibrahim, Priyanka Sharma, Walaa A. Abualsunun, Gamal A. Gabr. PI3K-AKT Pathway Modulation by Thymoquinone Limits Tumor Growth and Glycolytic Metabolism in Colorectal Cancer. International Journal of Molecular Sciences 2022; 23(4) doi: 10.3390/ijms23042305
5
Ammad Ahmad Farooqi, Rukset Attar, Baojun Xu. Anticancer and Anti-Metastatic Role of Thymoquinone: Regulation of Oncogenic Signaling Cascades by Thymoquinone. International Journal of Molecular Sciences 2022; 23(11) doi: 10.3390/ijms23116311
6
Belal Almajali, Hamid Ali Nagi Al-Jamal, Wan Rohani Wan Taib, Imilia Ismail, Muhammad Farid Johan, Abd Almonem Doolaanea, Wisam Nabeel Ibrahim. Thymoquinone, as a Novel Therapeutic Candidate of Cancers. Pharmaceuticals 2021; 14(4) doi: 10.3390/ph14040369
7
Opeyemi Oluwafemi Ojueromi, Ganiyu Oboh, Ayokunle Olubode Ademosun. Black Seed (Nigella sativa): A Favourable Alternative Therapy for Inflammatory and Immune System Disorders. Inflammopharmacology 2022; 30(5) doi: 10.1007/s10787-022-01035-6
8
Sankhadip Bose, Sabyasachi Banerjee, Arijit Mondal, Utsab Chakraborty, Joshua Pumarol, Courtney R. Croley, Anupam Bishayee. Targeting the JAK/STAT Signaling Pathway Using Phytocompounds for Cancer Prevention and Therapy. Cells 2020; 9(6) doi: 10.3390/cells9061451
9
Reem Ali Hamed, Wamidh H. Talib. Targeting cisplatin resistance in breast cancer using a combination of Thymoquinone and Silymarin: an in vitro and in vivo study. Pharmacia 2024; 71 doi: 10.3897/pharmacia.71.e117997
10
Wamidh H. Talib, Safa Daoud, Asma Ismail Mahmod, Reem Ali Hamed, Dima Awajan, Sara Feras Abuarab, Lena Hisham Odeh, Samar Khater, Lina T. Al Kury. Plants as a Source of Anticancer Agents: From Bench to Bedside. Molecules 2022; 27(15) doi: 10.3390/molecules27154818
11
Suryaa Manoharan, Ekambaram Perumal. A strategic review of STAT3 signaling inhibition by phytochemicals for cancer prevention and treatment: Advances and insights. Fitoterapia 2024; 179 doi: 10.1016/j.fitote.2024.106265
12
Belal Almajali, Muhammad Farid Johan, Abdullah Saleh Al-Wajeeh, Wan Rohani Wan Taib, Imilia Ismail, Maysa Alhawamdeh, Nafe M. Al-Tawarah, Wisam Nabeel Ibrahim, Futoon Abedrabbu Al-Rawashde, Hamid Ali Nagi Al-Jamal. Gene Expression Profiling and Protein Analysis Reveal Suppression of the C-Myc Oncogene and Inhibition JAK/STAT and PI3K/AKT/mTOR Signaling by Thymoquinone in Acute Myeloid Leukemia Cells. Pharmaceuticals 2022; 15(3) doi: 10.3390/ph15030307
13
Xue Hu, Jingjing Ma, Vikash Vikash, Jiao Li, Dandan Wu, Ya Liu, Jixiang Zhang, Weiguo Dong. Thymoquinone Augments Cisplatin-Induced Apoptosis on Esophageal Carcinoma Through Mitigating the Activation of JAK2/STAT3 Pathway. Digestive Diseases and Sciences 2018; 63(1) doi: 10.1007/s10620-017-4856-8
14
Jia‐Ru Wang, Gui‐Nan Shen, Ying‐Hua Luo, Xian‐Ji Piao, Meng Shen, Chang Liu, Yue Wang, Ling‐Qi Meng, Yi Zhang, Hao Wang, Jin‐Qian Li, Wan‐Ting Xu, Yang Liu, Hu‐Nan Sun, Ying‐Hao Han, Mei‐Hua Jin, Long‐Kui Cao, Cheng‐Hao Jin. The compound 2‐(naphthalene‐2‐thio)‐5,8‐dimethoxy‐1,4‐naphthoquinone induces apoptosis via reactive oxygen species‐regulated mitogen‐activated protein kinase, protein kinase B, and signal transducer and activator of transcription 3 signaling in human gastric cancer cells. Drug Development Research 2018; 79(6) doi: 10.1002/ddr.21442
15
Pallavi C. Mandave, Kaumudi M. Bhawe, Manasi Deshpande, Jayanta K. Das, Prabhakar K. Ranjekar. A contextual understanding of cell-based molecular pathway interactions of ayurvedic phytochemicals in gastro-intestinal cancers. Phytomedicine Plus 2026; 6(3) doi: 10.1016/j.phyplu.2026.101015
16
Marta Ribeiro, Manuel Simões. Health Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids. 2020;  doi: 10.1007/978-3-030-15147-8_28
17
Shailaja Dombe, Pramodkumar Shirote. Nanosponges Encapsulated Phytochemicals for Targeting Cancer: A Review. Current Drug Targets 2021; 22(4) doi: 10.2174/1389450121999201012201455
18
Aya O. Bashir, Mohamed E. El-Mesery, Rokiah Anwer, Laila A. Eissa. Thymoquinone potentiates miR-16 and miR-375 expressions in hepatocellular carcinoma. Life Sciences 2020; 254 doi: 10.1016/j.lfs.2020.117794
19
Md. Yousuf Ali, Zakia Akter, Zhiqiang Mei, Meiling Zheng, Mousumi Tania, Md. Asaduzzaman Khan. Thymoquinone in autoimmune diseases: Therapeutic potential and molecular mechanisms. Biomedicine & Pharmacotherapy 2021; 134 doi: 10.1016/j.biopha.2020.111157
20
Qing Lv, Jin-Xia Hu, You-Jie Li, Ning Xie, Dan Dan Song, Wei Zhao, Yun-Fei Yan, Bao-Sheng Li, Ping-Yu Wang, Shu-Yang Xie. MiR-320a effectively suppresses lung adenocarcinoma cell proliferation and metastasis by regulating STAT3 signals. Cancer Biology & Therapy 2017; 18(3) doi: 10.1080/15384047.2017.1281497
21
Mina Homayoonfal, Zatollah Asemi, Bahman Yousefi. Targeting microRNAs with thymoquinone: a new approach for cancer therapy. Cellular & Molecular Biology Letters 2021; 26(1) doi: 10.1186/s11658-021-00286-5
22
Md. Asaduzzaman Khan, Mousumi Tania, Shangyi Fu, Junjiang Fu. Thymoquinone, as an anticancer molecule: from basic research to clinical investigation. Oncotarget 2017; 8(31) doi: 10.18632/oncotarget.17206
23
Getinet M. Adinew, Equar Taka, Bereket Mochona, Ramesh B. Badisa, Elizabeth A. Mazzio, Rashid Elhag, Karam F. A. Soliman. Therapeutic Potential of Thymoquinone in Triple-Negative Breast Cancer Prevention and Progression through the Modulation of the Tumor Microenvironment. Nutrients 2021; 14(1) doi: 10.3390/nu14010079
24
Li-Min Feng, Xue-Feng Wang, Qing-Xian Huang. Thymoquinone induces cytotoxicity and reprogramming of EMT in gastric cancer cells by targeting PI3K/Akt/mTOR pathway. Journal of Biosciences 2017; 42(4) doi: 10.1007/s12038-017-9708-3
25
Pengzhan He, Yang He, Jingjing Ma, Yinghui Liu, Chuan Liu, Yu Baoping, Weiguo Dong. Thymoquinone induces apoptosis and protective autophagy in gastric cancer cells by inhibiting the PI3K/Akt/mTOR pathway. Phytotherapy Research 2023; 37(8) doi: 10.1002/ptr.7820
26
Sawsan Elgohary, Aya A. Elkhodiry, Nada S. Amin, Ulrike Stein, Hend M. El Tayebi. Thymoquinone: A Tie-Breaker in SARS-CoV2-Infected Cancer Patients?. Cells 2021; 10(2) doi: 10.3390/cells10020302
27
Elham Razmpoosh, Sara Safi, Mahta Mazaheri, Amin Salehi-Abargouei, Nooshin Abdollahi, Majid Nazari, Hossein Fallahzadeh, Azadeh Nadjarzadeh. Effects of oral Nigella sativa oil on the expression levels and serum concentrations of adiponectin, PPAR-γ, and TNF-α in overweight and obese women: a study protocol for a crossover-designed, double-blind, placebo-controlled randomized clinical trial. Trials 2019; 20(1) doi: 10.1186/s13063-019-3568-0
28
Gauri Kapoor, Swati Prakash, Vishakha Jaiswal, Ashok K Singh. Chronic Inflammation and Cancer: Key Pathways and Targeted Therapies. Cancer Investigation 2025; 43(1) doi: 10.1080/07357907.2024.2437614
29
Muhammad Imran, Abdur Rauf, Imtiaz Ali Khan, Muhammad Shahbaz, Tahira Batool Qaisrani, Sri Fatmawati, Tareq Abu-Izneid, Ali Imran, Khaliq Ur Rahman, Tanweer Aslam Gondal. Thymoquinone: A novel strategy to combat cancer: A review. Biomedicine & Pharmacotherapy 2018; 106 doi: 10.1016/j.biopha.2018.06.159
30
Morteza Akhzari, Shiva Mohammadi, Sajad Jalili, Mahdi Barazesh, Karim Noorizadeh. Nigella sativa, a Jack of All Trades Plant in Medicine: Pharmacological Aspects in Diseases Treatment and Prevention. The Natural Products Journal 2023; 13(6) doi: 10.2174/2210315513666221005093047
31
Patrycja Kłos, Magdalena Perużyńska, Magdalena Baśkiewicz-Hałasa, Paulina Skupin-Mrugalska, Małgorzata Majcher, Magdalena Sawczuk, Bartosz Szostak, Marek Droździk, Bogusław Machaliński, Dariusz Chlubek. Response of Skin-Derived and Metastatic Human Malignant Melanoma Cell Lines to Thymoquinone and Thymoquinone-Loaded Liposomes. Pharmaceutics 2022; 14(11) doi: 10.3390/pharmaceutics14112309
32
Xi Deng, Zhongming Yang, Kim Wei Chan, Norsharina Ismail, Md Zuki Abu Bakar. 5-Fluorouracil in Combination with Calcium Carbonate Nanoparticles Loaded with Antioxidant Thymoquinone against Colon Cancer: Synergistically Therapeutic Potential and Underlying Molecular Mechanism. Antioxidants 2024; 13(9) doi: 10.3390/antiox13091030
33
Mishari Alshyarba, Hassan Otifi, Majed Al Fayi, Ayed A Dera, Prasanna Rajagopalan. Thymoquinone inhibits IL‐7‐induced tumor progression and metastatic invasion in prostate cancer cells by attenuating matrix metalloproteinase activity and Akt/NF‐κB signaling. Biotechnology and Applied Biochemistry 2020;  doi: 10.1002/bab.2062
34
Saurav Bhattacharya, Avijit Ghosh, Santanu Maiti, Manisha Ahir, Gouranga H. Debnath, Payal Gupta, Mousumi Bhattacharjee, Swatilekha Ghosh, Sreya Chattopadhyay, Prasun Mukherjee, Arghya Adhikary. RETRACTED: Delivery of thymoquinone through hyaluronic acid-decorated mixed Pluronic® nanoparticles to attenuate angiogenesis and metastasis of triple-negative breast cancer. Journal of Controlled Release 2020; 322 doi: 10.1016/j.jconrel.2020.03.033
35
Mahmoud Alhosin. Thymoquinone is a novel potential inhibitor of SIRT1 in cancers with p53 mutation: Role in the reactivation of tumor suppressor p73. World Academy of Sciences Journal 2020;  doi: 10.3892/wasj.2020.49
36
Eray Metin Guler, Behice Hande Sisman, Abdurrahim Kocyigit, Mustafa Aziz Hatiboglu. Investigation of cellular effects of thymoquinone on glioma cell. Toxicology Reports 2021; 8 doi: 10.1016/j.toxrep.2020.12.026
37
Yumei Pu, Shiqi Hu, Yongfeng Chen, Qian Zhang, Chengwan Xia, Han Deng, Yuxin Wang, Qingang Hu. Thymoquinone loaded calcium alginate and polyvinyl alcohol carrier inhibits the 7,12‐dimethylbenz[a]anthracene‐induced hamster oral cancer via the down‐regulation of PI3K/AKT/mTOR signaling pathways. Environmental Toxicology 2021; 36(3) doi: 10.1002/tox.23040
38
Sandhya Shukla, Arvind Shukla, Navin Ray, Adarsha Upadhyay, Fowzul Fahad, Sayan Dutta, Arulkumar Nagappan, Raj Mongre. Targeting Pathways and Mechanisms in Gynecological Cancer with Antioxidant and Anti-Inflammatory Phytochemical Drugs. Onco 2025; 5(2) doi: 10.3390/onco5020024
39
Futoon Abedrabbu Al-Rawashde, Muhammad Farid Johan, Wan Rohani Wan Taib, Imilia Ismail, Syed Ahmad Tajudin Tuan Johari, Belal Almajali, Abdullah Saleh Al-wajeeh, Mansoureh Nazari Vishkaei, Hamid Ali Nagi Al-Jamal. Thymoquinone Inhibits Growth of Acute Myeloid Leukemia Cells through Reversal SHP-1 and SOCS-3 Hypermethylation: In Vitro and In Silico Evaluation. Pharmaceuticals 2021; 14(12) doi: 10.3390/ph14121287
40
Mahjabin Khan, Sze-Kwan Lam, Sheng Yan, Yuqian Feng, Caoyang Chen, Frankie Chi-Fat Ko, James Chung-Man Ho. The anti-neoplastic impact of thymoquinone from Nigella sativa on small cell lung cancer: In vitro and in vivo investigations. Journal of Cancer Research and Therapeutics 2024; 20(4) doi: 10.4103/jcrt.jcrt_883_23
41
Xi Deng, Md Zuki Abu Bakar, Zhongming Yang. Calcium carbonate nanoparticles loaded with thymoquinone derived from medicine food homology plants combined with 5-fluorouracil for colon cancer Treatment: Proteomic and metabolomic insights. Food Bioscience 2025; 70 doi: 10.1016/j.fbio.2025.107060
42
Muthu K. Shanmugam, Frank Arfuso, Alan Prem Kumar, Lingzhi Wang, Boon Cher Goh, Kwang Seok Ahn, Anupam Bishayee, Gautam Sethi. Modulation of diverse oncogenic transcription factors by thymoquinone, an essential oil compound isolated from the seeds of Nigella sativa Linn. Pharmacological Research 2018; 129 doi: 10.1016/j.phrs.2017.11.023
43
Lehe Yang, Shichong Lin, Lingyuan Xu, Jiayuh Lin, Chengguang Zhao, Xiaoying Huang. Novel activators and small-molecule inhibitors of STAT3 in cancer. Cytokine & Growth Factor Reviews 2019; 49 doi: 10.1016/j.cytogfr.2019.10.005
44
Arshad H. Rahmani. Molecular and Therapeutic actions of Thymoquinone. 2018;  doi: 10.1007/978-981-10-8800-1_3
45
Wamidh H. Talib, Izzeddin Alsalahat, Safa Daoud, Reem Fawaz Abutayeh, Asma Ismail Mahmod. Plant-Derived Natural Products in Cancer Research: Extraction, Mechanism of Action, and Drug Formulation. Molecules 2020; 25(22) doi: 10.3390/molecules25225319
46
Tina Rahjoo, Alireza Motamedzadeh, Felora Ferdosi, Ehsan Dadgostar, Michael Aschner, Hamed Mirzaei, Sina Ghesmatpour, Fatemeh Nabavizadeh, Fatemeh Rahmati-Dehkordi, Omid Reza Tamtaji. Potential role of thymoquinone to treat gastrointestinal cancers: insights into its molecular mechanisms. Naunyn-Schmiedeberg's Archives of Pharmacology 2025; 398(8) doi: 10.1007/s00210-025-03861-1
47
Sradhanjali Biswal, Saijyoti Parija, Pradipta Ranjan Rauta. Phytochemicals and Hallmarks of Cancer. 2026;  doi: 10.1016/B978-0-443-34084-0.00012-1
48
Fahadul Islam, Saikat Mitra, Talha Bin Emran, Zidan Khan, Nikhil Nath, Rajib Das, Rohit Sharma, Ahmed Abdullah Al Awadh, Moon Nyeo Park, Bonglee Kim. Natural Small Molecules in Gastrointestinal Tract and Associated Cancers: Molecular Insights and Targeted Therapies. Molecules 2022; 27(17) doi: 10.3390/molecules27175686
49
Prince Ahad Mir, Roohi Mohi-ud-din, Nazia Banday, Mudasir Maqbool, Syed Naeim Raza, Saeema Farooq, Suhaib Afzal, Reyaz Hassan Mir. Anticancer Potential of Thymoquinone: A Novel Bioactive Natural Compound from Nigella sativa L.. Anti-Cancer Agents in Medicinal Chemistry 2022; 22(20) doi: 10.2174/1871520622666220511233314
50
Camila Aline Romano, José Realino de Paula, Christianah A. Elusiyan, James O. Fajemiroye. Fundamentals of Drug and Non-Drug Interactions. 2025;  doi: 10.1007/978-3-031-80107-5_5
51
Pınar Çetinalp, Öykü Gönül Geyik, Senanur Malcanlı, Sevgin Değirmencioğlu, Sevda Tanrıkulu Küçük, Hikmet Koçak, Engin Ulukaya. Investigatıon of Apoptotic Effects of Thymoquinone on Glioblastoma Cells. Bratislava Medical Journal 2025; 126(6) doi: 10.1007/s44411-025-00116-6
52
Mahsa Rezvan, Seyed Erfan Hossini, Kimia Sarmast, Faham Khamesipour. The Efficiency of Plant Extracts in the Prevention of Gastric Cancer: A Systematic Review. Health Science Reports 2025; 8(9) doi: 10.1002/hsr2.71251
53
Amin F. Majdalawieh, Muneera W. Fayyad, Gheyath K. Nasrallah. Anti-cancer properties and mechanisms of action of thymoquinone, the major active ingredient of Nigella sativa . Critical Reviews in Food Science and Nutrition 2017; 57(18) doi: 10.1080/10408398.2016.1277971
54
Sylwia Nakonieczna, Aneta Grabarska, Wirginia Kukula-Koch. The Potential Anticancer Activity of Phytoconstituents against Gastric Cancer—A Review on In Vitro, In Vivo, and Clinical Studies. International Journal of Molecular Sciences 2020; 21(21) doi: 10.3390/ijms21218307
55
Chandan Sarkar, Sarmin Jamaddar, Tawhida Islam, Milon Mondal, Muhammad Torequl Islam, Mohammad S. Mubarak. Therapeutic perspectives of the black cumin component thymoquinone: A review. Food & Function 2021; 12(14) doi: 10.1039/D1FO00401H
56
Md. Rezaul Islam, Abdur Rauf, Shopnil Akash, Ajoy Kumer, Md Sadique Hussain, Smrity Akter, Jeetendra Kumar Gupta, L.H. Thameemul Ansari, Mir Md. Mahfoj Islam Raj, Talha Bin Emran, Abdullah S.M. Aljohani, Waleed Al Abdulmonem, Rekha Thiruvengadam, Muthu Thiruvengadam. Recent perspective on the potential role of phytocompounds in the prevention of gastric cancer. Process Biochemistry 2023; 135 doi: 10.1016/j.procbio.2023.11.006
57
Deepika Godugu, Rameswari Chilamakuri, Saurabh Agarwal. STAT3 axis in cancer and cancer stem cells: From oncogenesis to targeted therapies. Biochimica et Biophysica Acta (BBA) - Reviews on Cancer 2025; 1880(6) doi: 10.1016/j.bbcan.2025.189461
58
Zakia Akter, Faiza Rafa Ahmed, Mousumi Tania, Md. Asaduzzaman Khan. Targeting Inflammatory Mediators: An Anticancer Mechanism of Thymoquinone Action. Current Medicinal Chemistry 2020; 28(1) doi: 10.2174/0929867326666191011143642
59
Amit S. Choudhari, Pallavi C. Mandave, Manasi Deshpande, Prabhakar Ranjekar, Om Prakash. Phytochemicals in Cancer Treatment: From Preclinical Studies to Clinical Practice. Frontiers in Pharmacology 2020; 10 doi: 10.3389/fphar.2019.01614
60
Mahmoud Balbaa, Marwa El-Zeftawy, Shaymaa A. Abdulmalek, Yasmin R. Shahin. Black cumin (Nigella sativa) seeds: Chemistry, Technology, Functionality, and Applications. Food Bioactive Ingredients 2021;  doi: 10.1007/978-3-030-48798-0_23
61
Marta Ribeiro, Manuel Simões. Health Consequences of Microbial Interactions with Hydrocarbons, Oils, and Lipids. 2019;  doi: 10.1007/978-3-319-72473-7_28-1
62
Peng Gao, Na Niu, Tianshu Wei, Hideto Tozawa, Xiaocui Chen, Caiqing Zhang, Jiandong Zhang, Youichiro Wada, Carolyn M. Kapron, Ju Liu. The roles of signal transducer and activator of transcription factor 3 in tumor angiogenesis. Oncotarget 2017; 8(40) doi: 10.18632/oncotarget.19932
63
Saber Imani, Chunli Wei, Jingliang Cheng, Md. Asaduzzaman Khan, Shangyi Fu, Luquan Yang, Mousumi Tania, Xianqin Zhang, Xiuli Xiao, Xianning Zhang, Junjiang Fu. MicroRNA-34a targets epithelial to mesenchymal transition-inducing transcription factors (EMT-TFs) and inhibits breast cancer cell migration and invasion. Oncotarget 2017; 8(13) doi: 10.18632/oncotarget.15214
64
Niraj Kumar Jha, Saniya Arfin, Saurabh Kumar Jha, Rohan Kar, Abhijit Dey, Rohit Gundamaraju, Ghulam Md. Ashraf, Piyush Kumar Gupta, Sugapriya Dhanasekaran, Mosleh Mohammad Abomughaid, Sabya Sachi Das, Sachin Kumar Singh, Kamal Dua, Shubhadeep Roychoudhury, Dhruv Kumar, Janne Ruokolainen, Shreesh Ojha, Kavindra Kumar Kesari. Re-establishing the comprehension of phytomedicine and nanomedicine in inflammation-mediated cancer signaling. Seminars in Cancer Biology 2022; 86 doi: 10.1016/j.semcancer.2022.02.022
65
Abdul Waheed Khan, Mariya Farooq, Muhammad Haseeb, Sangdun Choi. Role of Plant-Derived Active Constituents in Cancer Treatment and Their Mechanisms of Action. Cells 2022; 11(8) doi: 10.3390/cells11081326
66
Aqsa Khan, Asifa Khan, Mohammad Aasif Khan, Zoya Malik, Sheersh Massey, Rabea Parveen, Saad Mustafa, Anas Shamsi, Syed A. Husain. Phytocompounds targeting epigenetic modulations: an assessment in cancer. Frontiers in Pharmacology 2024; 14 doi: 10.3389/fphar.2023.1273993
67
Milad Ashrafizadeh, Ali Zarrabi, Sima Orouei, Vahideh Zarrin, Ebrahim Rahmani Moghadam, Amirhossein Zabolian, Shima Mohammadi, Kiavash Hushmandi, Yashar Gharehaghajlou, Pooyan Makvandi, Masoud Najafi, Reza Mohammadinejad. STAT3 Pathway in Gastric Cancer: Signaling, Therapeutic Targeting and Future Prospects. Biology 2020; 9(6) doi: 10.3390/biology9060126
68
Mina Homayoonfal, Zatollah Asemi, Bahman Yousefi. Potential anticancer properties and mechanisms of thymoquinone in osteosarcoma and bone metastasis. Cellular & Molecular Biology Letters 2022; 27(1) doi: 10.1186/s11658-022-00320-0
69
Katarzyna Kostelecka, Łukasz Bryliński, Olga Komar, Justyna Michalczyk, Agata Miłosz, Jan Biłogras, Filip Woliński, Alicja Forma, Jacek Baj. An Overview of the Spices Used for the Prevention and Potential Treatment of Gastric Cancer. Cancers 2024; 16(8) doi: 10.3390/cancers16081611
70
Xue Hu, Fangzhou Jiao, Lan Zhang, Yingan Jiang. Dihydrotanshinone Inhibits Hepatocellular Carcinoma by Suppressing the JAK2/STAT3 Pathway. Frontiers in Pharmacology 2021; 12 doi: 10.3389/fphar.2021.654986
71
Bhagyalakshmi Nair, Anjana Menon, M. Rithwik Kalidas, Lekshmi R. Nath, Daniela Calina, Javad Sharifi-Rad. Modulating the JAK/STAT pathway with natural products: potential and challenges in cancer therapy. Discover Oncology 2025; 16(1) doi: 10.1007/s12672-025-02369-7
72
Vildan Betul Yenigun, Hasan Acar, Ebru Kanimdan, Alper Yenigun, Abdurrahim Kocyigit, Tulin Cora. KRAS Mutation Reduces Thymoquinone Anticancer Effects on Viability of Cells and Apoptosis. Anti-Cancer Agents in Medicinal Chemistry 2023; 23(15) doi: 10.2174/1871520623666230517123807
73
Manzar Alam, Gulam Mustafa Hasan, Md Meraj Ansari, Rishi Sharma, Dharmendra Kumar Yadav, Md Imtaiyaz Hassan. Therapeutic implications and clinical manifestations of thymoquinone. Phytochemistry 2022; 200 doi: 10.1016/j.phytochem.2022.113213
74
Amr Mohamed, Asfar S. Azmi, Sylvia L. Asa, Sree Harsha Tirumani, Amit Mahipal, Sakti Cjakrabarti, David Bajor, J. Eva Selfridge, Ahmed O. Kaseb. Thymoquinone Plus Immunotherapy in Extra-Pulmonary Neuroendocrine Carcinoma: Case Series for a Novel Combination. Current Oncology 2022; 29(11) doi: 10.3390/curroncol29110707
75
Shabana Tabassum, Norhayati Rosli, Solachuddin Jauhari Arief Ichwan, Puranjan Mishra. Thymoquinone and its pharmacological perspective: A review. Pharmacological Research - Modern Chinese Medicine 2021; 1 doi: 10.1016/j.prmcm.2021.100020
76
Flama Monteiro, Shilpa S. Shetty, Suchetha Kumari N. Natural antioxidants as inhibitors of pyruvate kinase M2 in Warburg phenotypes. Journal of Herbal Medicine 2023; 42 doi: 10.1016/j.hermed.2023.100750
77
Ochbayasakh Dashdondov, Junaid Wazir, Ganbolor Sukhbaatar, Reyaj Mikrani, Buyankhishig Dorjsuren, Nasrin Aktar, Xiaohui Zhou. Herbal nutraceutical treatment of chronic prostatitis–chronic pelvic pain syndrome: a literature review. International Urology and Nephrology 2021; 53(8) doi: 10.1007/s11255-021-02868-w
78
. Studies in Natural Products Chemistry 2025; 84 doi: 10.1016/B978-0-443-23752-2.00009-8
79
Fabliha Ahmed Chowdhury, Md Kamal Hossain, A. G. M. Mostofa, Maruf Mohammad Akbor, Muhammad Shahdaat Bin Sayeed. Therapeutic Potential of Thymoquinone in Glioblastoma Treatment: Targeting Major Gliomagenesis Signaling Pathways. BioMed Research International 2018; 2018 doi: 10.1155/2018/4010629
80
Kübra Bozali̇, Zeynep İnce, Nurhi̇lal Kiziltoprak, Taygun Gülşen, Mehmet Köstek, Yasi̇r Kesgi̇n, Muhammer Ergenç, Mi̇ne Dağgez, Eren Altun, Fati̇h Taşkesen, Cebrai̇l Akyüz, Oğuzhan Sunamak, Mustafa Duman, Eray Güler. Cytotoxic, apoptotic and genotoxic effects of thymoquinone‑oxime derivative on gastric cancer cells: An in vitro study. Oncology Letters 2026; 31(3) doi: 10.3892/ol.2026.15462
81
Mimoune Berehab, Redouane Rouas, Haidar Akl, Hugues Duvillier, Fabrice Journe, Hussein Fayyad-Kazan, Ghanem Ghanem, Dominique Bron, Philippe Lewalle, Makram Merimi. Apoptotic and Non-Apoptotic Modalities of Thymoquinone-Induced Lymphoma Cell Death: Highlight of the Role of Cytosolic Calcium and Necroptosis. Cancers 2021; 13(14) doi: 10.3390/cancers13143579
82
Syeda Samira Afrose, Md. Junaid, Yeasmin Akter, Mousumi Tania, Meiling Zheng, Md. Asaduzzaman Khan. Targeting kinases with thymoquinone: a molecular approach to cancer therapeutics. Drug Discovery Today 2020; 25(12) doi: 10.1016/j.drudis.2020.07.019
83
Jingjing Ma, Xue Hu, Jiao Li, Dandan Wu, Qingzhi Lan, Qian Wang, Shan Tian, Weiguo Dong. Enhancing conventional chemotherapy drug cisplatin-induced anti-tumor effects on human gastric cancer cells both in vitro and in vivo by Thymoquinone targeting PTEN gene. Oncotarget 2017; 8(49) doi: 10.18632/oncotarget.20721
84
Futoon Abedrabbu Al-Rawashde, Abdullah Saleh Al-wajeeh, Mansoureh Nazari Vishkaei, Hanan Kamel M. Saad, Muhammad Farid Johan, Wan Rohani Wan Taib, Imilia Ismail, Hamid Ali Nagi Al-Jamal. Thymoquinone Inhibits JAK/STAT and PI3K/Akt/ mTOR Signaling Pathways in MV4-11 and K562 Myeloid Leukemia Cells. Pharmaceuticals 2022; 15(9) doi: 10.3390/ph15091123
85
Fahad Khan, Pratibha Pandey, Meenakshi Verma, Tarun Kumar Upadhyay. Terpenoid-Mediated Targeting of STAT3 Signaling in Cancer: An Overview of Preclinical Studies. Biomolecules 2024; 14(2) doi: 10.3390/biom14020200
86
Taghreed A. Majrashi, Saad Ali Alshehri, Abdulrhman Alsayari, Abdullatif Bin Muhsinah, Mohammad Alrouji, Asma M. Alshahrani, Anas Shamsi, Akhtar Atiya. Insight into the Biological Roles and Mechanisms of Phytochemicals in Different Types of Cancer: Targeting Cancer Therapeutics. Nutrients 2023; 15(7) doi: 10.3390/nu15071704
87
. Studies in Natural Products Chemistry 2025; 85 doi: 10.1016/B978-0-443-23754-6.00013-6
88
Pawan Kumar Raghav, Zoya Mann, Vishnu Krishnakumar, Sujata Mohanty. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. 2021;  doi: 10.1007/978-981-15-4501-6_116-1
89
Ajaikumar B. Kunnumakkara, Bethsebie L. Sailo, Kishore Banik, Choudhary Harsha, Sahdeo Prasad, Subash Chandra Gupta, Alok Chandra Bharti, Bharat B. Aggarwal. Chronic diseases, inflammation, and spices: how are they linked?. Journal of Translational Medicine 2018; 16(1) doi: 10.1186/s12967-018-1381-2
90
Alexander Chota, Blassan P. George, Heidi Abrahamse. Potential Treatment of Breast and Lung Cancer Using Dicoma anomala, an African Medicinal Plant. Molecules 2020; 25(19) doi: 10.3390/molecules25194435
91
Milad Ashrafizadeh, Hossein Rafiei, Reza Mohammadinejad, Elham G. Afshar, Tahereh Farkhondeh, Saeed Samarghandian. Potential therapeutic effects of curcumin mediated by JAK/STAT signaling pathway: A review. Phytotherapy Research 2020; 34(8) doi: 10.1002/ptr.6642
92
Pawan Kumar Raghav, Zoya Mann, Vishnu Krishnakumar, Sujata Mohanty. Handbook of Oxidative Stress in Cancer: Mechanistic Aspects. 2022;  doi: 10.1007/978-981-15-9411-3_116
93
Farah Ballout, Alissar Monzer, Maamoun Fatfat, Hala El Ouweini, Miran A. Jaffa, Rana Abdel-Samad, Nadine Darwiche, Wassim Abou-Kheir, Hala Gali-Muhtasib. Thymoquinone induces apoptosis and DNA damage in 5-Fluorouracil-resistant colorectal cancer stem/progenitor cells. Oncotarget 2020; 11(31) doi: 10.18632/oncotarget.27426
94
Reem Fawaz Abutayeh, Maram Altah, Amani Mehdawi, Israa Al-Ataby, Adel Ardakani. Chemopreventive Agents from Nature: A Review of Apigenin, Rosmarinic Acid, and Thymoquinone. Current Issues in Molecular Biology 2024; 46(7) doi: 10.3390/cimb46070393
95
Bunty Sharma, Himanshu Shekhar, Anidrisha Sahu, Shafiul Haque, Damandeep Kaur, Hardeep Singh Tuli, Ujjawal Sharma. Deciphering the anticancer potential of thymoquinone: in-depth exploration of the potent flavonoid from Nigella sativa. Molecular Biology Reports 2025; 52(1) doi: 10.1007/s11033-025-10375-9
96
Vrushali Manoj Hadkar, Chirasmita Mohanty, Chinnadurai Immanuel Selvaraj. Biopolymeric nanocarriers in cancer therapy: unleashing the potency of bioactive anticancer compounds for enhancing drug delivery. RSC Advances 2024; 14(35) doi: 10.1039/D4RA03911D