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Feb 21, 2015 (publication date) through Feb 15, 2025
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World Journal of Gastroenterology
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1007-9327
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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
| For: | He Q, Li JK, Li F, Li RG, Zhan GQ, Li G, Du WX, Tan HB. Mechanism of action of gypenosides on type 2 diabetes and non-alcoholic fatty liver disease in rats. World J Gastroenterol 2015; 21(7): 2058-2066 [PMID: 25717238 DOI: 10.3748/wjg.v21.i7.2058] |
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| URL: | https://www.wjgnet.com/1007-9327/full/v21/i7/2058.htm |
| Number | Citing Articles |
| 1 |
Yue Li. Gypenoside A attenuates dysfunction of pancreatic β cells by activating PDX1 signal transduction via the inhibition of miR‐150‐3p both in vivo and in vitro. Journal of Biochemical and Molecular Toxicology 2022; 36(4) doi: 10.1002/jbt.23004
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| 2 |
Jiakai Han, Wei Gao, Dongyue Su, Yang Liu. Gypenoside inhibits RANKL‐induced osteoclastogenesis by regulating NF‐κB, AKT, and MAPK signaling pathways. Journal of Cellular Biochemistry 2018; 119(9): 7310 doi: 10.1002/jcb.27028
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| 3 |
Jin Ha Lee, Ji Young Oh, Soo Hyun Kim, In Jeong Oh, Yong-ho Lee, Keun Woo Lee, Woong Hee Lee, Jeong-Hwan Kim. Pharmaceutical Efficacy of Gypenoside LXXV on Non-Alcoholic Steatohepatitis (NASH). Biomolecules 2020; 10(10): 1426 doi: 10.3390/biom10101426
|
| 4 |
Lincoln Biswas, Zhihong Zeng, Annette Graham, Xinhua Shu. Gypenosides mediate cholesterol efflux and suppress oxidized LDL induced inflammation in retinal pigment epithelium cells. Experimental Eye Research 2020; 191: 107931 doi: 10.1016/j.exer.2020.107931
|
| 5 |
Hongyan Tan, Minjie Li, Linlin Han, Yuqing Zhao, Xiaoshu Zhang. Gypensapogenin I Suppresses Cell Proliferation in Triple-Negative Breast Cancer Via Triggering the Closure of AKT/GSK3β/β-Catenin and Notch-1 Signaling Pathways. Journal of Agricultural and Food Chemistry 2022; 70(17): 5438 doi: 10.1021/acs.jafc.2c02512
|
| 6 |
Gouxin Huang, Muhammad Yasir, Yilin Zheng, Imran Khan. Prebiotic properties of jiaogulan in the context of gut microbiome. Food Science & Nutrition 2022; 10(3): 731 doi: 10.1002/fsn3.2701
|
| 7 |
Jianmei WANG, Xianting WANG, Tingting ZHOU, Lin QIN, Di WU, Yimei DU, Qianru ZHANG, Yuqi HE, Daopeng TAN. Inhibitory activity of Gypensapogenin D against α-glucosidase and preparation of its liposomes. Food Science and Technology 2023; 43 doi: 10.1590/fst.108722
|
| 8 |
Jie Wei, Yong-Zhan Zhen, Ju Cui, Fa-Lin He, Tao Shen, Gang Hu, Xiao-Hong Ren, Ya-Jun Lin. Rhein lysinate decreases inflammation and adipose infiltration in KK/HlJ diabetic mice with non-alcoholic fatty liver disease. Archives of Pharmacal Research 2016; 39(7): 960 doi: 10.1007/s12272-016-0770-4
|
| 9 |
Shuhua Shen, Kungen Wang, Yihui Zhi, Wei Shen, Liquan Huang. Gypenosides improves nonalcoholic fatty liver disease induced by high-fat diet induced through regulating LPS/TLR4 signaling pathway. Cell Cycle 2020; 19(22): 3042 doi: 10.1080/15384101.2020.1829800
|
| 10 |
Jian Xie, Mingxia Luo, Qiuyi Chen, Qianru Zhang, Lin Qin, Yuhe Wang, Yongxia Zhao, Yuqi He. Hypolipidemic effect and gut microbiota regulation of Gypenoside aglycones in rats fed a high-fat diet. Journal of Ethnopharmacology 2024; 328: 118066 doi: 10.1016/j.jep.2024.118066
|
| 11 |
Yanbo Fan, Wei Xiong, Jingjing Li, Aimin Hu, Zhiwei He, Jiawen Zhang, Guoyun Zhou, Qiang Yin. Mechanism of TangGanJian on nonalcoholic fatty liver disease with type 2 diabetes mellitus. Pharmaceutical Biology 2018; 56(1): 567 doi: 10.1080/13880209.2018.1504972
|
| 12 |
Hui Zhang, Hanzhou Li, Baochao Pan, Shufang Zhang, Xiuhai Su, Wenjuan Sun, Tianyu Zhang, Zhaiyi Zhang, Shuquan Lv, Huantian Cui. Integrated 16S rRNA Sequencing and Untargeted Metabolomics Analysis to Reveal
the Protective Mechanisms of Polygonatum sibiricum Polysaccharide on Type 2 Diabetes
Mellitus Model Rats. Current Drug Metabolism 2023; 24(4): 270 doi: 10.2174/1389200224666230406114012
|
| 13 |
Hailiang Ma, Yuanben Lu, Dewen Zhu, Zhenhua Jiang, FanZhi Zhang, Jun Peng, Li Wang. Gypenoside A Protects Human Myocardial Cells from Ischemia/Reperfusion Injury via the circ_0010729/miR-370-3p/RUNX1 Axis. Biochemistry (Moscow) 2024; 89(5): 973 doi: 10.1134/S000629792405016X
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| 14 |
Nizomiddin Kodirov, Elvira Galiakhmetova, Alfina Nizamova, Natalya Kudashkina, Renata Galiakhmetova, Svetlana Rashitovna, N. Yakovenko, S. Ignatieva, D. Ushakov. Biological study of gynostemma pentaphyllum (thunb.) Makino. BIO Web of Conferences 2024; 93: 02001 doi: 10.1051/bioconf/20249302001
|
| 15 |
Ma‐Li Zu, Xiang‐Lan Piao, Jia‐Mei Gao, Shao‐Fang Xing, Lin‐Hua Liu. Monomer gypenoside LI from Gynostemma pentaphyllum inhibits cell proliferation and upregulates expression of miR‐128‐3p in melanoma cells. Journal of Biochemical and Molecular Toxicology 2020; 34(5) doi: 10.1002/jbt.22460
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| 16 |
Ya-Ping Huang, Yun-Shan Wang, Yuan-Yuan Liu, Cui-Hua Jiang, Jie Wang, Xin-Yu Jiang, Bi-Wen Liu, Lei Wang, Wen-Cai Ye, Jian Zhang, Zhi-Qi Yin, Ke Pan. Chemical Characterization and Atherosclerosis Alleviation Effects of Gypenosides from Gynostemma pentaphyllum through Ameliorating Endothelial Dysfunction via the PCSK9/LOX-1 Pathway. Journal of Agricultural and Food Chemistry 2022; 70(38): 11944 doi: 10.1021/acs.jafc.2c02681
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| 17 |
Hongshan Li, Yingfei Xi, Xin Xin, Huajie Tian, Yiyang Hu. Gypenosides regulate farnesoid X receptor-mediated bile acid and lipid metabolism in a mouse model of non-alcoholic steatohepatitis. Nutrition & Metabolism 2020; 17(1) doi: 10.1186/s12986-020-00454-y
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| 18 |
Fengling Wang, Yifan Wu, Xiaoting Xie, Jing Sun, Weidong Chen. Essential role of nuclear receptors for the evaluation of the benefits of bioactive herbal extracts on liver function. Biomedicine & Pharmacotherapy 2018; 99: 798 doi: 10.1016/j.biopha.2018.01.012
|
| 19 |
Zhang Yuanyuan, Liu Huaizhen, Jian-You Guo. Mechanistic Research into the Effects of the Jianpi Xiaozhi Formula on Liver Injury in Diabetic Rats. Evidence-Based Complementary and Alternative Medicine 2022; 2022: 1 doi: 10.1155/2022/7490747
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| 20 |
Jiamei Chen, Xuewei Li, Yonghong Hu, Wei Liu, Qun Zhou, Hua Zhang, Yongping Mu, Ping Liu. Gypenosides Ameliorate Carbon Tetrachloride-Induced Liver Fibrosis by Inhibiting the Differentiation of Hepatic Progenitor Cells into Myofibroblasts. The American Journal of Chinese Medicine 2017; 45(05): 1061 doi: 10.1142/S0192415X17500574
|
| 21 |
Qiongdan Hu, Wan Liao, Zhen Zhang, Sanjun Shi, Shuguang Hou, Ningping Ji, Xinjie Zhang, Qian Zhang, Yangyang Liao, Linghui Li, Zongping Zhu, Yi Chen, Jiao Chen, Fangkun Yu, Qingsong Yang, Hongtao Xiao, Chaomei Fu, Hengjun Du, Qi Wang, Heping Cao, Hang Xiao, Rui Li. The hepatoprotective effects of plant-based foods based on the “gut–liver axis”: a prospective review. Critical Reviews in Food Science and Nutrition 2023; 63(28): 9136 doi: 10.1080/10408398.2022.2064423
|
| 22 |
Man‐Yu Xiao, Si Li, Wen‐Jing Pei, Yu‐Long Gu, Xiang‐Lan Piao. Natural Saponins on Cholesterol‐Related Diseases: Treatment and Mechanism. Phytotherapy Research 2025; doi: 10.1002/ptr.8432
|
| 23 |
Fang Wang, Yalong Dang, Jing Wang, Ting Zhou, Yu Zhu. Gypenosides attenuate lipopolysaccharide-induced optic neuritis in rats. Acta Histochemica 2018; 120(4): 340 doi: 10.1016/j.acthis.2018.03.003
|
| 24 |
Yanliu Lu, Yimei Du, Lin Qin, Di Wu, Wei Wang, Lei Ling, Feifei Ma, Hua Ling, Li Yang, Changhong Wang, Zhengtao Wang, Xumei Zhou, Yuqi He, Yoshiji Ohta. Gypenosides Altered Hepatic Bile Acids Homeostasis in Mice Treated with High Fat Diet. Evidence-Based Complementary and Alternative Medicine 2018; 2018(1) doi: 10.1155/2018/8098059
|
| 25 |
Tingting Zhou, Ligang Cao, Yimei Du, Lin Qin, Yanliu Lu, Qianru Zhang, Yuqi He, Daopeng Tan. Gypenosides ameliorate high-fat diet-induced nonalcoholic fatty liver disease in mice by regulating lipid metabolism. PeerJ 2023; 11: e15225 doi: 10.7717/peerj.15225
|
| 26 |
Xueqin Zhao, Weiyu Luo, Lei Wang, Chunling Zhu, Xianghong Xue, Xiaojing Xia, Xilong Wu, Yueyu Bai, Jianhe Hu. Antimicrobial peptide Mastoparan X has good activity against Escherichia coli in vitro and alleviates its pathogenicity in mice. Translational Medicine Communications 2023; 8(1) doi: 10.1186/s41231-023-00145-9
|
| 27 |
Ui-Jin Bae, Eun-Ock Park, John Park, Su-Jin Jung, Hyeonmi Ham, Kee-Won Yu, Young-Jun Park, Soo-Wan Chae, Byung-Hyun Park. Gypenoside UL4-RichGynostemma pentaphyllumExtract Exerts a Hepatoprotective Effect on Diet-Induced Nonalcoholic Fatty Liver Disease. The American Journal of Chinese Medicine 2018; 46(06): 1315 doi: 10.1142/S0192415X18500696
|
| 28 |
Reem Hasaballah Alhasani, Lincoln Biswas, Ali Mohammad Tohari, Xinzhi Zhou, James Reilly, Jian-Feng He, Xinhua Shu. Gypenosides protect retinal pigment epithelium cells from oxidative stress. Food and Chemical Toxicology 2018; 112: 76 doi: 10.1016/j.fct.2017.12.037
|
| 29 |
Yantao Li, Wanjun Lin, Jiajun Huang, Ying Xie, Wenzhe Ma. Anti-cancer effects of Gynostemma pentaphyllum (Thunb.) Makino (Jiaogulan). Chinese Medicine 2016; 11(1) doi: 10.1186/s13020-016-0114-9
|
| 30 |
Meng Zhang, Jie Li, Xin Guo, Xiaoting Wang, Dongping Shi, Lin Cui, Yu Zhou. Co-administration of berberine/gypenosides/bifendate ameliorates metabolic disturbance but not memory impairment in type 2 diabetic mice. Heliyon 2021; 7(1): e06004 doi: 10.1016/j.heliyon.2021.e06004
|
| 31 |
Yutian Wang, Junzi Wu, Anhua Shi. Literature Review on the Use of Herbal Extracts in the Treatment of Non-
Alcoholic Fatty Liver Disease. Endocrine, Metabolic & Immune Disorders - Drug Targets 2022; 22(11): 1123 doi: 10.2174/1871530322666220408123746
|
| 32 |
Zhaolin Sun, Yuhua Wei, Yuchen Xu, Jianwei Jiao, Xiuying Duan. The use of traditional Chinese medicine in the treatment of non-alcoholic fatty liver disease: A review. Pharmacological Research - Modern Chinese Medicine 2024; 12: 100475 doi: 10.1016/j.prmcm.2024.100475
|
| 33 |
Jinliang Du, Rui Jia, Li-ping Cao, Weidong Ding, Pao Xu, Guojun Yin. Effects of Rhizoma Alismatis extract on biochemical indices and adipose gene expression in oleic acid-induced hepatocyte injury in Jian carp (Cyprinus carpio var. Jian). Fish Physiology and Biochemistry 2018; 44(3): 747 doi: 10.1007/s10695-017-0428-2
|
| 34 |
Mengyuan Li, Hongyan Tan, Ting Gao, Linlin Han, Xinhang Teng, Fang Wang, Xiaoshu Zhang. Gypensapogenin I Ameliorates Isoproterenol (ISO)-Induced Myocardial Damage through Regulating the TLR4/NF-κB/NLRP3 Pathway. Molecules 2022; 27(16): 5298 doi: 10.3390/molecules27165298
|
| 35 |
Gökçe Kuzgun, Rahman Başaran, Ebru Arıoğlu İnan, Benay Can Eke. Effects of insulin treatment on hepatic CYP1A1 and CYP2E1 activities and lipid peroxidation levels in streptozotocin-induced diabetic rats. Journal of Diabetes & Metabolic Disorders 2020; 19(2): 1157 doi: 10.1007/s40200-020-00616-y
|
| 36 |
Wen-Yi Deng, Cheng-Long Zhou, Meng-Ya Zeng. Gypenoside XVII inhibits ox-LDL-induced macrophage inflammatory responses and promotes cholesterol efflux through activating the miR-182-5p/HDAC9 signaling pathway. Journal of Ethnopharmacology 2024; 319: 117070 doi: 10.1016/j.jep.2023.117070
|
| 37 |
Peng Xie, Hao-Tian Luo, Wen-Jing Pei, Man-Yu Xiao, Fang-Fang Li, Yu-Long Gu, Xiang-Lan Piao. Saponins derived from Gynostemma pentaphyllum regulate triglyceride and cholesterol metabolism and the mechanisms: A review. Journal of Ethnopharmacology 2024; 319: 117186 doi: 10.1016/j.jep.2023.117186
|
| 38 |
Ngoc-Hieu Nguyen, Thi Kim Quy Ha, Jun-Li Yang, Ha Thanh Tung Pham, Won Keun Oh. Triterpenoids from the genus Gynostemma: Chemistry and pharmacological activities. Journal of Ethnopharmacology 2021; 268: 113574 doi: 10.1016/j.jep.2020.113574
|
| 39 |
Kaijun Li, Chao Ma, Haoyu Li, Sooranna Dev, JianFeng He, Xiaosheng Qu. Medicinal Value and Potential Therapeutic Mechanisms of Gynostemma pentaphyllum (Thunb.) Makino and Its Derivatives: An Overview. Current Topics in Medicinal Chemistry 2020; 19(31): 2855 doi: 10.2174/1568026619666191114104718
|
| 40 |
Junjun Wang, Ting Zhai, Yong Chen. Effects of Honokiol on CYP450 Activity and Transporter mRNA Expression in Type 2 Diabetic Rats. International Journal of Molecular Sciences 2018; 19(3): 815 doi: 10.3390/ijms19030815
|
| 41 |
Li Pan, Bingxue Lan, Shoumin Li, Yong Jin, Miaomiao Cui, Ying Xia, Sixi Wei, Hai Huang. Gypenoside inhibits gastric cancer proliferation by suppressing glycolysis via the Hippo pathway. Scientific Reports 2024; 14(1) doi: 10.1038/s41598-024-69435-y
|
| 42 |
Yanbo Fan, Zhiwei He, Wei Wang, Jingjing Li, Aimin Hu, Li Li, Ling Yan, Zhijie Li, Qiang Yin. Tangganjian decoction ameliorates type 2 diabetes mellitus and nonalcoholic fatty liver disease in rats by activating the IRS/PI3K/AKT signaling pathway. Biomedicine & Pharmacotherapy 2018; 106: 733 doi: 10.1016/j.biopha.2018.06.089
|
| 43 |
Yonghong Hu, Xiaoli He, Xiaoxi Zhou, Yue Liang, Yadong Fu, Linzhang Zhang, Jing Fang, Wei Liu, Gaofeng Chen, Yongping Mu, Hua Zhang, Hong Cai, Chenghai Liu, Ping Liu, Jiamei Chen. Gypenosides ameliorate ductular reaction and liver fibrosis via inhibition of hedgehog signaling. Frontiers in Pharmacology 2022; 13 doi: 10.3389/fphar.2022.1033103
|
| 44 |
Ziang Ma, Wenjuan Sun, Lixin Wang, Yuansong Wang, Baochao Pan, Xiuhai Su, Hanzhou Li, Hui Zhang, Shuquan Lv, Hongwu Wang. Integrated 16S rRNA sequencing and nontargeted metabolomics analysis to reveal the mechanisms of Yu-Ye Tang on type 2 diabetes mellitus rats. Frontiers in Endocrinology 2023; 14 doi: 10.3389/fendo.2023.1159707
|
| 45 |
Yanyan Xia, Yuanying Zhang, Mengjiao Shen, Hongpan Xu, Zhiyang Li, Nongyue He. Golgi protein 73 and its diagnostic value in liver diseases. Cell Proliferation 2019; 52(2) doi: 10.1111/cpr.12538
|
| 46 |
Ma-Li Zu, Yu Duan, Jin-Bo Xie, Yan-Shuang Qi, Peng Xie, Almaz Borjigidai, Xiang-Lan Piao. Gypenoside LI arrests the cell cycle of breast cancer in G0/G1 phase by down-regulating E2F1. Journal of Ethnopharmacology 2021; 273: 114017 doi: 10.1016/j.jep.2021.114017
|
| 47 |
Yu-Jie Jiang, Ye-Ming Cao, Yong-Bing Cao, Tian-Hua Yan, Cheng-Lin Jia, Ping He. A Review: Cytochrome P450 in Alcoholic and Non-Alcoholic Fatty Liver Disease. Diabetes, Metabolic Syndrome and Obesity 2024; : 1511 doi: 10.2147/DMSO.S449494
|