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For: Ali A, Abdel-Hafiz H, Suhail M, Al-Mars A, Zakaria MK, Fatima K, Ahmad S, Azhar E, Chaudhary A, Qadri I. Hepatitis B virus, HBx mutants and their role in hepatocellular carcinoma. World J Gastroenterol 2014; 20(30): 10238-10248 [PMID: 25132741 DOI: 10.3748/wjg.v20.i30.10238]
URL: https://www.wjgnet.com/1007-9327/full/v20/i30/10238.htm
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Number Citing Articles
1
Yibin Deng, Zhongheng Wei, Meijin Huang, Guidan Xu, Wujun Wei, Bin Peng, Shunqiang Nong, Houji Qin. Long non‐coding RNA F11‐AS1 inhibits HBV‐related hepatocellular carcinoma progression by regulating NR1I3 via binding to microRNA‐211‐5p. Journal of Cellular and Molecular Medicine 2020; 24(2) doi: 10.1111/jcmm.14881
2
Enakshi Sivasudhan, Neil Blake, Zhiliang Lu, Jia Meng, Rong Rong. Hepatitis B Viral Protein HBx and the Molecular Mechanisms Modulating the Hallmarks of Hepatocellular Carcinoma: A Comprehensive Review. Cells 2022; 11(4) doi: 10.3390/cells11040741
3
Canyu Liu, Kaitao Zhao, Yingshan Chen, Yongxuan Yao, Jielin Tang, Jingjing Wang, Chonghui Xu, Qi Yang, Yi Zheng, Yifei Yuan, Hao Sun, Yongli Zhang, Yuan Zhou, Jizheng Chen, Yun Wang, Chunchen Wu, Rongjuan Pei, Xinwen Chen, J.-H. James Ou. Mitochondrial Glycerol-3-Phosphate Dehydrogenase Restricts HBV Replication via the TRIM28-Mediated Degradation of HBx. Journal of Virology 2023; 97(5) doi: 10.1128/jvi.00580-23
4
Chia‐Jui Yen, Yu‐Lin Ai, Hung‐Wen Tsai, Shih‐Huang Chan, Chia‐Sheng Yen, Kuang‐Hsiung Cheng, Yun‐Ping Lee, Chia‐Wei Kao, Yu‐Chun Wang, Yi‐Lin Chen, Cheng‐Han Lin, Tsunglin Liu, Huey‐Pin Tsai, Jen‐Ren Wang, Ih‐Jen Su, Wenya Huang. Hepatitis B virus surface gene pre‐S2 mutant as a high‐risk serum marker for hepatoma recurrence after curative hepatic resection. Hepatology 2018; 68(3) doi: 10.1002/hep.29790
5
Surya Agung Priyambada, Ryo Misaki, Toru Okamoto, Yuta Okamoto, Takao Ohashi, Keiji Ueda, Yoshiharu Matsuura, Kazuhito Fujiyama. Cell surface N-glycan alteration in HepAD38 cell lines expressing Hepatitis B virus. Virus Research 2017; 238 doi: 10.1016/j.virusres.2017.06.003
6
Javid Sadri Nahand, Nikta Rabiei, Reza Fathazam, Mohammad Taghizadieh, Mohammad Saeid Ebrahimi, Maryam Mahjoubin-Tehran, Hossein Bannazadeh Baghi, AliReza Khatami, Mohammad Abbasi-Kolli, Hamid Reza Mirzaei, Neda Rahimian, Maryam Darvish, Hamed Mirzaei. Oncogenic viruses and chemoresistance: What do we know?. Pharmacological Research 2021; 170 doi: 10.1016/j.phrs.2021.105730
7
Philip Lawrence, Mawlouda Chabane, Lucie Abrouk, Adrien Thiesson, Diakaridia Berthé, Amadou B. Diarra, Karim Bengaly, Brehima Traoré, Djibril Kassogué, Geoffroy Durand, Catherine Voegele, Florence Le Calvez-Kelm, Nicolas Steenkeste, Pierre Hainaut, Bourema Kouriba, Emmanuelle Gormally. First Molecular Characterization of Chronic Hepatitis B Carriers in Timbuktu, Mali. Diagnostics 2023; 13(3) doi: 10.3390/diagnostics13030375
8
Xiazhen Xu, Lu Zhang, Guiying Ye, Jiajian Shi, Yibin Peng, Fan Xin, Yi Lin, Qiong Wu, Xu Lin, Wannan Chen, J.-H. James Ou. Hepatitis B doubly spliced protein (HBDSP) promotes hepatocellular carcinoma cell apoptosis via ETS1/GATA2/YY1-mediated p53 transcription. Journal of Virology 2023; 97(11) doi: 10.1128/jvi.01087-23
9
Jing-Jing Han, Yu Chen, Yu-Chen Nan, Yong-Lin Yang. Extremely high titer of hepatitis B surface antigen antibodies in a primary hepatocellular carcinoma patient: A case report. World Journal of Clinical Cases 2021; 9(28): 8492-8497 doi: 10.12998/wjcc.v9.i28.8492
10
Gurbet Celik-Turgut, Nazmiye Olmez, Tugba Koc, Ozden Ozgun-Acar, Asli Semiz, Yavuz Dodurga, Naciye Lale Satiroglu-Tufan, Alaattin Sen. Role of AHR, NF-kB and CYP1A1 crosstalk with the X protein of Hepatitis B virus in hepatocellular carcinoma cells. Gene 2023; 853 doi: 10.1016/j.gene.2022.147099
11
Fanyun Kong, Hongjuan You, Delong Kong, Kuiyang Zheng, Renxian Tang. The interaction of hepatitis B virus with the ubiquitin proteasome system in viral replication and associated pathogenesis. Virology Journal 2019; 16(1) doi: 10.1186/s12985-019-1183-z
12
Jingwen Xu, Nipa H. Patel, David A. Gewirtz. Triangular Relationship between p53, Autophagy, and Chemotherapy Resistance. International Journal of Molecular Sciences 2020; 21(23) doi: 10.3390/ijms21238991
13
Wenhui Tu, Yonghong Yang, Yulong Song, Weijun Zhu. Hepatitis B virus x protein accelerated the proliferation of hepatocellular carcinoma cell through lncRNA SNHG20/PTEN pathway. The Journal of Biochemistry 2019; 165(5) doi: 10.1093/jb/mvy120
14
Sanjit Boora, Vikrant Sharma, Sulochana Kaushik, Ajoy Varma Bhupatiraju, Sandeep Singh, Samander Kaushik. Hepatitis B virus-induced hepatocellular carcinoma: a persistent global problem. Brazilian Journal of Microbiology 2023; 54(2) doi: 10.1007/s42770-023-00970-y
15
Moulay Mustapha Ennaji. Cancer Biomarkers and Oncoviruses. 2026;  doi: 10.1016/B978-0-443-30225-1.00051-8
16
Xiaoying Han, Jing Yang, Dong Li, Zewei Guo. Overexpression of Uric Acid Transporter SLC2A9 Inhibits Proliferation of Hepatocellular Carcinoma Cells. Oncology Research Featuring Preclinical and Clinical Cancer Therapeutics 2019; 27(5) doi: 10.3727/096504018X15199489058224
17
Barbara Grasiele Müller-Coan, Brunno Felipe Ramos Caetano, Joseph Stephen Pagano, Deilson Elgui de Oliveira. Cancer Progression Goes Viral: The Role of Oncoviruses in Aggressiveness of Malignancies. Trends in Cancer 2018; 4(7) doi: 10.1016/j.trecan.2018.04.006
18
Yandan Wu, Yan Ding, Chuanlai Shen. A Systematic Review of T Cell Epitopes Defined from the Proteome of Hepatitis B Virus. Vaccines 2022; 10(2) doi: 10.3390/vaccines10020257
19
Maria Guadalupe Martinez, Anders Boyd, Emmanuel Combe, Barbara Testoni, Fabien Zoulim. Covalently closed circular DNA: The ultimate therapeutic target for curing HBV infections. Journal of Hepatology 2021; 75(3) doi: 10.1016/j.jhep.2021.05.013
20
Pu-Yang Gong, Zhi-Xiang Yuan, Jian Gu, Rui Tan, Jia-Chuan Li, Yan Ren, Sha Hu. Anti-HBV Activities of Three Compounds Extracted and Purified from Herpetospermum Seeds. Molecules 2016; 22(1) doi: 10.3390/molecules22010014
21
Wen-Shu Chen, Liang-Chih Liu, Chia-Jui Yen, Yun-Ju Chen, Jhen-Yu Chen, Chien-Yi Ho, Shu-Hui Liu, Ching-Chow Chen, Wei-Chien Huang. Nuclear IKKα mediates microRNA-7/-103/107/21 inductions to downregulate maspin expression in response to HBx overexpression. Oncotarget 2016; 7(35) doi: 10.18632/oncotarget.10462
22
Gulsum Ozlem Elpek. Molecular pathways in viral hepatitis-associated liver carcinogenesis: An update. World Journal of Clinical Cases 2021; 9(19): 4890-4917 doi: 10.12998/wjcc.v9.i19.4890
23
Stavros P. Papadakos, Ioanna E. Stergiou, Nikolina Gkolemi, Konstantinos Arvanitakis, Stamatios Theocharis. Unraveling the Significance of EPH/Ephrin Signaling in Liver Cancer: Insights into Tumor Progression and Therapeutic Implications. Cancers 2023; 15(13) doi: 10.3390/cancers15133434
24
Théodora Mahoukèdè Zohoncon, Denise P. Ilboudo, Lionel Dahourou, Titeon Rose Clémence Ido Da, Luc Zongo, Jacques Simpore. Clinical and Paraclinical Profiling of Patients with Viral Hepatitis B and C Attending Saint Camille Hospital in Ouagadougou (HOSCO). Journal of Biosciences and Medicines 2023; 11(10) doi: 10.4236/jbm.2023.1110021
25
Jella-Andrea Abraham, Olga Golubnitschaja. Time for Paradigm Change in Management of Hepatocellular Carcinoma: Is a Personalized Approach on the Horizon?. Personalized Medicine 2016; 13(5) doi: 10.2217/pme-2016-0013
26
Wing Sum Shin, Fuda Xie, Bonan Chen, Jun Yu, Kwok Wai Lo, Gary M. K. Tse, Ka Fai To, Wei Kang. Exploring the Microbiome in Gastric Cancer: Assessing Potential Implications and Contextualizing Microorganisms beyond H. pylori and Epstein-Barr Virus. Cancers 2023; 15(20) doi: 10.3390/cancers15204993
27
Mohammad Darvishi, Majid Nouri, Rasoul Rahimi, Saeid Heidari-Soureshjani, Seyed Mahmoud Reza Hashemi Rafsanjani. A Systematic Review of the Impact of Resveratrol on Viral Hepatitis and Chronic Viral Hepatitis-related Hepatocellular Carcinoma. Current Molecular Medicine 2025; 25(5) doi: 10.2174/0115665240284347240125072555
28
Jianhua Zhong, Yuetong Li, Yang Liu, Jie Qiao, Yiling Wu, Xinyi Kong, Miao Qi, Yiqi Lin, Yaqi Yao, Ying Jin, Changlong Bi, Aixia Zhai, Li Shen. Hepatitis B virus X protein (HBx)-mediated immune modulation and prognostic model development in hepatocellular carcinoma. PLOS One 2025; 20(6) doi: 10.1371/journal.pone.0325363
29
Yichen Yang, Yuequn Ma, Meng Yuan, Yonglin Peng, Zhonghai Fang, Ju Wang. Identifying the biomarkers and pathways associated with hepatocellular carcinoma based on an integrated analysis approach. Liver International 2021; 41(10) doi: 10.1111/liv.14972
30
Jing Li, Yan Zhang, Bing Luo. Effects of Exosomal Viral Components on the Tumor Microenvironment. Cancers 2022; 14(14) doi: 10.3390/cancers14143552
31
Zaheenul Islam Siddiqui, Syed Ali Azam, Wajihul Hasan Khan, Masarrat Afroz, Sabihur Rahman Farooqui, Fatima Amir, Md Iqbal Azmi, Ayesha Anwer, Saniya Khan, Mahboubeh Mehmankhah, Shama Parveen, Syed Naqui Kazim. An in vitro Study on the Role of Hepatitis B Virus X Protein C-Terminal Truncation in Liver Disease Development. Frontiers in Genetics 2021; 12 doi: 10.3389/fgene.2021.633341
32
Sachiyo Onishi, Masahiro Tajika, Tsutomu Tanaka, Keisaku Yamada, Tomoyasu Kamiya, Seiji Natsume, Yasuhiro Shimizu, Yasumasa Niwa. Juvenile Hepatocellular Carcinoma in a Healthy Liver. Internal Medicine 2022; 61(10) doi: 10.2169/internalmedicine.8305-21
33
Hashim Ali, Sheikh Abdul Rahman, Junaid Akhtar, Syed Asfarul Haque, Safdar Ali. Editorial: Decoding the genetics of viral evolution. Frontiers in Genetics 2022; 13 doi: 10.3389/fgene.2022.978485
34
Maria Lina Tornesello, Luigi Buonaguro, Francesco Izzo, Franco M. Buonaguro. Molecular alterations in hepatocellular carcinoma associated with hepatitis B and hepatitis C infections. Oncotarget 2016; 7(18) doi: 10.18632/oncotarget.7837
35
Shuchang Lou, Weili Sun, Yuan Wu. Biochemical overview of the recent findings on the correlation between viral hepatitis and its related hepatocellular carcinoma. Oncology and Translational Medicine 2018; 4(6) doi: 10.1007/s10330-018-0305-5
36
Kai Zhu, Wenwen Huang, Wenju Wang, Liwei Liao, Shuo Li, Songlin Yang, Jingyi Xu, Lin Li, Mingyao Meng, Yanhua Xie, Shan He, Weiwei Tang, Haodong Zhou, Luxin Liang, Hui Gao, Yiyi Zhao, Zongliu Hou, Jing Tan, Ruhong Li. Up-regulation of S100A4 expression by HBx protein promotes proliferation of hepatocellular carcinoma cells and its correlation with clinical survival. Gene 2020; 749 doi: 10.1016/j.gene.2020.144679
37
Litao Zheng. Analysis of hepatocellular carcinoma associated with hepatitis B virus. Journal of Cellular and Molecular Medicine 2023; 27(16) doi: 10.1111/jcmm.17867
38
Hung-Wen Tsai, Yun-Ping Lee, Chia-Jui Yen, Kuang-Hsiung Cheng, Chien-Jung Huang, Wenya Huang. The Serum Hepatitis B Virus Large Surface Protein as High-Risk Recurrence Biomarker for Hepatoma after Curative Surgery. International Journal of Molecular Sciences 2022; 23(10) doi: 10.3390/ijms23105376
39
Yong Gao, Juan Gu, Yueping Wang, Decai Fu, Wensheng Zhang, Guofu Zheng, Xuedong Wang. Hepatitis B virus X protein boosts hepatocellular carcinoma progression by downregulating microRNA-137. Pathology - Research and Practice 2020; 216(6) doi: 10.1016/j.prp.2020.152981
40
Hongjuan You, Suping Qin, Fulong Zhang, Wei Hu, Xiaocui Li, Dongsheng Liu, Fanyun Kong, Xiucheng Pan, Kuiyang Zheng, Renxian Tang. Regulation of Pattern-Recognition Receptor Signaling by HBX During Hepatitis B Virus Infection. Frontiers in Immunology 2022; 13 doi: 10.3389/fimmu.2022.829923
41
Xiaocui Li, Delong Kong, Wei Hu, Kuiyang Zheng, Hongjuan You, Renxian Tang, Fanyun Kong. Insight into the mechanisms regulating liver cancer stem cells by hepatitis B virus X protein. Infectious Agents and Cancer 2024; 19(1) doi: 10.1186/s13027-024-00618-y
42
Zheng-Kun Tu, Guo Zhou, Yang Yang, Tian-Yang Li. Immune suppression in chronic hepatitis B infection associated liver disease: A review. World Journal of Gastroenterology 2019; 25(27): 3527-3537 doi: 10.3748/wjg.v25.i27.3527
43
Hui‐Juan Liu, Yan‐Chao Hu, Zi‐Min Ma, Li‐Na Ma, Xiang‐Chun Ding. HBx Promotes the Malignant Advancement of Hepatitis B Virus‐Associated Hepatocellular Carcinoma by Increasing ENO1 Expression. Journal of Biochemical and Molecular Toxicology 2026; 40(4) doi: 10.1002/jbt.70797
44
Maryam Tahmasebi Birgani, Vinicio Carloni. Tumor Microenvironment, a Paradigm in Hepatocellular Carcinoma Progression and Therapy. International Journal of Molecular Sciences 2017; 18(2) doi: 10.3390/ijms18020405
45
Yanshuo Ye, Yunpeng Shi, Zhenhong Wei, Hongyu Liu, Wei Li. SIGIRR suppresses hepatitis B virus X protein-induced chronic inflammation in hepatocytes. Gene 2024; 928 doi: 10.1016/j.gene.2024.148768
46
Bum-Joon Kim, Seoung-Ae Lee, Hong Kim. X region mutations of hepatitis B virus related to clinical severity. World Journal of Gastroenterology 2016; 22(24): 5467-5478 doi: 10.3748/wjg.v22.i24.5467
47
Zeineb Belaiba, Kaouther Ayouni, Mariem Gdoura, Wafa Kammoun Rebai, Henda Touzi, Amel Sadraoui, Walid Hammemi, Lamia Yacoubi, Salwa Abdelati, Lamine Hamzaoui, Mohamed Msaddak Azzouz, Anissa Chouikha, Henda Triki. Whole genome analysis of hepatitis B virus before and during long-term therapy in chronic infected patients: Molecular characterization, impact on treatment and liver disease progression. Frontiers in Microbiology 2022; 13 doi: 10.3389/fmicb.2022.1020147
48
Wei Yan, Dean Rao, Feimu Fan, Huifang Liang, Zunyi Zhang, Hanhua Dong. Hepatitis B virus X protein and TGF-β: partners in the carcinogenic journey of hepatocellular carcinoma. Frontiers in Oncology 2024; 14 doi: 10.3389/fonc.2024.1407434
49
Zhi-Jun Su, Jia-Shou Cao, Yan-Fang Wu, Wan-Nan Chen, Xinjian Lin, Yun-Li Wu, Xu Lin. Deubiquitylation of hepatitis B virus X protein (HBx) by ubiquitin-specific peptidase 15 (USP15) increases HBx stability and its transactivation activity. Scientific Reports 2017; 7(1) doi: 10.1038/srep40246
50
Wei Hu, Dongsheng Liu, Renjie Li, Hong Qian, Wei Qiu, Qingwang Ye, Fanyun Kong. Comprehensive Analysis of TRIM Family Genes in Hepatitis Virus B-Related Hepatoma Carcinoma. Frontiers in Genetics 2022; 13 doi: 10.3389/fgene.2022.913743
51
Fatima Fasih, Nusrat Jabeen, Mushtaq Hussain, Atiya Habib, Shaheen Sharafat, Zaheer Ul-Haq. Structural and antigenic variation in Hepatitis B virus oncogene, HBx. Journal of Biomolecular Structure and Dynamics 2026; 44(8) doi: 10.1080/07391102.2025.2517826
52
Ah Ram Lee, Keo-Heun Lim, Eun-Sook Park, Doo Hyun Kim, Yong Kwang Park, Soree Park, Dong-Sik Kim, Gu-Choul Shin, Hong Seok Kang, Juhee Won, Heewoo Sim, Yea Na Ha, Byeongjune Jae, Seong Il Choi, Kyun-Hwan Kim, J.-H. James Ou. Multiple Functions of Cellular FLIP Are Essential for Replication of Hepatitis B Virus. Journal of Virology 2018; 92(16) doi: 10.1128/JVI.00339-18
53
Jinchen Liu, Xueqin Wu, Qiushi Yin, Luying Zhang, Kun Liu, Kailin Huang, Junnv Xu, Xiaowei Li, Bo Lin, Mingyue Zhu, Mengsen Li. HBx Drives Liver Cancer Stem Cell Generation Through Stimulating Glucose Metabolic Reprogramming. Journal of Cellular and Molecular Medicine 2025; 29(14) doi: 10.1111/jcmm.70722
54
Evanthia Tourkochristou, Stelios F. Assimakopoulos, Konstantinos Thomopoulos, Markos Marangos, Christos Triantos. NAFLD and HBV interplay - related mechanisms underlying liver disease progression. Frontiers in Immunology 2022; 13 doi: 10.3389/fimmu.2022.965548
55
Fu-Hsiung Su, Thi Nga Le, Chih-Hsin Muo, Sister Arlene Te, Fung-Chang Sung, Chih-Ching Yeh. Chronic Hepatitis B Virus Infection Associated with Increased Colorectal Cancer Risk in Taiwanese Population. Viruses 2020; 12(1) doi: 10.3390/v12010097
56
Haofeng Yin, Yibo Xue, Chen Wang, Yanqin Wu, Yuchen Guo, Chunzhen Li, Yunyan Zhang, Shulei Yin, Tiejun Zhao. UBE2N as a novel prognostic and therapeutic biomarker of lung adenocarcinoma. Frontiers in Immunology 2025; 16 doi: 10.3389/fimmu.2025.1636503
57
Ming Wang, Dong Xi, Qin Ning. Virus-induced hepatocellular carcinoma with special emphasis on HBV. Hepatology International 2017; 11(2) doi: 10.1007/s12072-016-9779-5
58
Soree Park, Yea Na Ha, Mehrangiz Dezhbord, Ah Ram Lee, Eun-Sook Park, Yong Kwang Park, Juhee Won, Na Yeon Kim, Soo Yeun Choo, Jae Jin Shin, Chang Hyun Ahn, Kyun-Hwan Kim. Suppression of Hepatocyte Nuclear Factor 4 α by Long-term Infection of Hepatitis B Virus Contributes to Tumor Cell Proliferation. International Journal of Molecular Sciences 2020; 21(3) doi: 10.3390/ijms21030948
59
Jitendra Kumar, Ankita Singh, Purnima Tyagi, Deepti Sharma, Shiv Kumar Sarin, Vijay Kumar. New thiourea derivatives that target the episomal silencing SMC5 protein to inhibit HBx-dependent viral DNA replication and gene transcription. VirusDisease 2024; 35(4) doi: 10.1007/s13337-024-00895-6
60
Arthur Zimmermann. Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. 2016;  doi: 10.1007/978-3-319-26587-2_164-1
61
Weimin Wang, Ya'e Shi, Guiqin Bai, Yao Tang, Yongxing Yuan, Ting Zhang, Chen Li. HBxAg suppresses apoptosis of human placental trophoblastic cell lines via activation of the PI3K/Akt pathway. Cell Biology International 2016; 40(6) doi: 10.1002/cbin.10608
62
Kurt Sartorius, Leo Swadling, Ping An, Julia Makarova, Cheryl Winkler, Anil Chuturgoon, Anna Kramvis. The Multiple Roles of Hepatitis B Virus X Protein (HBx) Dysregulated MicroRNA in Hepatitis B Virus-Associated Hepatocellular Carcinoma (HBV-HCC) and Immune Pathways. Viruses 2020; 12(7) doi: 10.3390/v12070746
63
Caixia Zhu, Qing Zhu, Chong Wang, Liming Zhang, Fang Wei, Qiliang Cai. Hostile takeover: Manipulation of HIF-1 signaling in pathogen-associated cancers (Review). International Journal of Oncology 2016; 49(4) doi: 10.3892/ijo.2016.3633
64
Maria Francesca Cortese, Carolina González, Josep Gregori, Rosario Casillas, Luca Carioti, Mercedes Guerrero-Murillo, Mar Riveiro-Barciela, Cristina Godoy, Sara Sopena, Marçal Yll, Josep Quer, Ariadna Rando, Rosa Lopez-Martinez, Beatriz Pacín Ruiz, Selene García-García, Rafael Esteban-Mur, David Tabernero, Maria Buti, Francisco Rodríguez-Frías. Sophisticated viral quasispecies with a genotype-related pattern of mutations in the hepatitis B X gene of HBeAg-ve chronically infected patients. Scientific Reports 2021; 11(1) doi: 10.1038/s41598-021-83762-4
65
Chia-Jui Yen, Shu-Ting Yang, Ruo-Yu Chen, Wenya Huang, Kazuaki Chayama, Ming-Hao Lee, Shiang-Jie Yang, Hong-Sheng Lai, Hsin-Yi Yen, Yu-Wei Hsiao, Ju-Ming Wang, Yih-Jyh Lin, Liang-Yi Hung. Hepatitis B virus X protein (HBx) enhances centrosomal P4.1-associated protein (CPAP) expression to promote hepatocarcinogenesis. Journal of Biomedical Science 2019; 26(1) doi: 10.1186/s12929-019-0534-9
66
Qing Xiao, Yi Liu, Tingting Li, Chaoyu Wang, Sanxiu He, Liuyue Zhai, Zailin Yang, Xiaomei Zhang, Yongzhong Wu, Yao Liu. Viral oncogenesis in cancer: from mechanisms to therapeutics. Signal Transduction and Targeted Therapy 2025; 10(1) doi: 10.1038/s41392-025-02197-9
67
Hong-Bin Jiao, Wei Wang, Meng-Nan Guo, Ya-Li Su, De-Quan Pang, Bao-Lin Wang, Jun Shi, Jing-Hua Wu. Evaluation of high-risk factors and the diagnostic value of alpha-fetoprotein in the stratification of primary liver cancer. World Journal of Clinical Cases 2022; 10(26): 9264-9275 doi: 10.12998/wjcc.v10.i26.9264
68
Lingjun Chen, Xianyi Lin, Yiming Lei, Xuan Xu, Qi Zhou, Yan Chen, Huiling Liu, Jie Jiang, Yidong Yang, Fengping Zheng, Bin Wu. Aerobic glycolysis enhances HBx-initiated hepatocellular carcinogenesis via NF-κBp65/HK2 signalling. Journal of Experimental & Clinical Cancer Research 2022; 41(1) doi: 10.1186/s13046-022-02531-x
69
Yu Zhang, Hongli Liu, Ruitian Yi, Taotao Yan, Yingli He, Yingren Zhao, Jinfeng Liu. Hepatitis B virus whole-X and X protein play distinct roles in HBV-related hepatocellular carcinoma progression. Journal of Experimental & Clinical Cancer Research 2016; 35(1) doi: 10.1186/s13046-016-0366-3
70
Yigan Zhang, Huaze Xi, Xin Nie, Peng Zhang, Ning Lan, Ying Lu, Jinrong Liu, Wenzhen Yuan. Assessment of miR-212 and Other Biomarkers in the Diagnosis and Treatment of HBV-infection-related Liver Diseases. Current Drug Metabolism 2019; 20(10) doi: 10.2174/1389200220666191011120434
71
Yu-Min Choi, So-Young Lee, Bum-Joon Kim. Naturally Occurring Hepatitis B Virus Mutations Leading to Endoplasmic Reticulum Stress and Their Contribution to the Progression of Hepatocellular Carcinoma. International Journal of Molecular Sciences 2019; 20(3) doi: 10.3390/ijms20030597
72
Yu Qian, Boshi Wang, Aihui Ma, Li Zhang, Guiqin Xu, Qi Ding, Tiantian Jing, Lin Wu, Yun Liu, Zhaojuan Yang, Yongzhong Liu. USP16 Downregulation by Carboxyl-terminal Truncated HBx Promotes the Growth of Hepatocellular Carcinoma Cells. Scientific Reports 2016; 6(1) doi: 10.1038/srep33039
73
Siyan Chen, Luxi Wu, Lirong Peng, Xiaoqian Wang, Nanhong Tang. Hepatitis B virus X protein (HBx) promotes ST2 expression by GATA2 in liver cells. Molecular Immunology 2020; 123 doi: 10.1016/j.molimm.2020.04.024
74
Ci Song, Jun Lv, Yao Liu, Jian Guo Chen, Zijun Ge, Jian Zhu, Juncheng Dai, Ling-Bin Du, Canqing Yu, Yu Guo, Zheng Bian, Ling Yang, Yiping Chen, Zhengming Chen, Jibin Liu, Jie Jiang, Liguo Zhu, Xiangjun Zhai, Yue Jiang, Hongxia Ma, Guangfu Jin, Hongbing Shen, Liming Li, Zhibin Hu. Associations Between Hepatitis B Virus Infection and Risk of All Cancer Types. JAMA Network Open 2019; 2(6) doi: 10.1001/jamanetworkopen.2019.5718
75
Fanbiao Mei, Jingjing Ren, Long Long, Jilin Li, Kezhi Li, Haizhou Liu, Yanping Tang, Xiang Fang, Hanghang Wu, Chanchan Xiao, Tianren Huang, Wei Deng. Analysis of HBV X gene quasispecies characteristics by next‐generation sequencing and cloning‐based sequencing and its association with hepatocellular carcinoma progression. Journal of Medical Virology 2019; 91(6) doi: 10.1002/jmv.25421
76
Yanzhi Yuan, Chunyan Tian, Qiaoling Gong, Limin Shang, Yuehui Zhang, Chaozhi Jin, Fuchu He, Jian Wang. Interactome Map Reveals Phospholipid Scramblase 1 as a Novel Regulator of Hepatitis B Virus X Protein. Journal of Proteome Research 2015; 14(1) doi: 10.1021/pr500943x
77
Fanyun Kong, Hongjuan You, Renxian Tang, Kuiyang Zheng. The regulation of proteins associated with the cytoskeleton by hepatitis B virus X protein during hepatocarcinogenesis. Oncology Letters 2017; 13(4) doi: 10.3892/ol.2017.5757
78
Farzaneh Salarnia, Emad Behboudi, Iraj Shahramian, Abdolvahab Moradi. Novel X gene point mutations in chronic hepatitis B and HBV related cirrhotic patients. Infection, Genetics and Evolution 2022; 97 doi: 10.1016/j.meegid.2021.105186
79
Yuanyuan Ye, Jun Yang, Qin Hu, Jinju Mao, Qianfan Yang, Hong Chen, Dandan Li, Pu Li, Liang Duan, Bo Wang, Juan Chen, Weixian Chen. SIP1 serves a role in HBx‑induced liver cancer growth and metastasis. International Journal of Oncology 2019;  doi: 10.3892/ijo.2019.4884
80
Mohd Suhail, Sayed Sartaj Sohrab, Mohammad Amjad Kamal, Esam Ibraheem Azhar. Role of hepatitis c virus in hepatocellular carcinoma and neurological disorders: an overview. Frontiers in Oncology 2022; 12 doi: 10.3389/fonc.2022.913231
81
Yassir Hamadalnil, Hisham N. Altayb. In silico molecular study of hepatitis B virus X protein as a therapeutic target. Journal of Biomolecular Structure and Dynamics 2024; 42(8) doi: 10.1080/07391102.2023.2217920
82
Arthur Zimmermann. Tumors and Tumor-Like Lesions of the Hepatobiliary Tract. 2017;  doi: 10.1007/978-3-319-26956-6_164
83
Ahmed A. Al-Qahtani, Mashael R. Al-Anazi, Nyla Nazir, Rohit Ghai, Ayman A. Abdo, Faisal M. Sanai, Waleed K. Al-Hamoudi, Khalid A. Alswat, Hamad I. Al-Ashgar, Mohammed Q. Khan, Ali Albenmousa, Damian Dela Cruz, Marie Fe F. Bohol, Mohammed N. Al-Ahdal. Hepatitis B virus (HBV) X gene mutations and their association with liver disease progression in HBV-infected patients. Oncotarget 2017; 8(62) doi: 10.18632/oncotarget.22428
84
Jiahuan Zheng, Chunxu Chen, Chunqing Guo, Cody Caba, Yufeng Tong, Hengbin Wang. The Pleiotropic Ubiquitin-Specific Peptidase 16 and Its Many Substrates. Cells 2023; 12(6) doi: 10.3390/cells12060886
85
Jiarui Li, Ze Xiang, Yunyang Xu, Xingyu Luo, Yao Jiang, Yingchen Huang, Zhe Yang, Ronggao Chen, Xiao Xu. Targeting Cellular Senescence: A New Therapeutic Axis in Chronic Liver Disease. Engineering 2026;  doi: 10.1016/j.eng.2026.02.019
86
Tianshi Chen, Jinxian Pei, Jinjiang Wang, Ruili Luo, Lina Liu, Ling Wang, Hao Jia. HBx-related long non-coding RNA 01152 promotes cell proliferation and survival by IL-23 in hepatocellular carcinoma. Biomedicine & Pharmacotherapy 2019; 115 doi: 10.1016/j.biopha.2019.108877
87
Eun-Sook Park, Mehrangiz Dezhbord, Ah Ram Lee, Bo Bae Park, Kyun-Hwan Kim. Dysregulation of Liver Regeneration by Hepatitis B Virus Infection: Impact on Development of Hepatocellular Carcinoma. Cancers 2022; 14(15) doi: 10.3390/cancers14153566
88
Haram Sarfraz, Elhan Khan, Iffat Zareen Ahmad. Unveiling the potential of bioactive compounds from Linum usitatissimum L. to target Hepatocellular carcinoma: an in silico based approach . Journal of Biomolecular Structure and Dynamics 2026; 44(1) doi: 10.1080/07391102.2024.2439039
89
Kuldeep Kaur, Justine Beghin, Vanessa Meier-Stephenson. Comparative structural insights of X protein across species and the “lost” BH3-like domain that may explain the absence of hepatocellular carcinoma in birds. Infection, Genetics and Evolution 2025; 132 doi: 10.1016/j.meegid.2025.105777
90
Kurt Sartorius, Ping An, Cheryl Winkler, Anil Chuturgoon, Xiaodong Li, Julia Makarova, Anna Kramvis. The Epigenetic Modulation of Cancer and Immune Pathways in Hepatitis B Virus-Associated Hepatocellular Carcinoma: The Influence of HBx and miRNA Dysregulation. Frontiers in Immunology 2021; 12 doi: 10.3389/fimmu.2021.661204
91
Shahab Mahmoudvand, Zahra Ramezannia, Arastoo Kaki, Somayeh Shokri. Hepatitis B Virus - Pathogenesis and Therapeutic Approaches. 2024;  doi: 10.5772/intechopen.1005972
92
The oncogenic role of hepatitis B virus X gene in hepatocarcinogenesis: recent updates. Exploration of Targeted Anti-tumor Therapy 2024; 5(1) doi: 10.37349/etat.2024.00209
93
Ting-wei Peng, Qing-feng Ma, Jie Li, Xue Wang, Cong-hui Zhang, Junwen Ma, Jun-yi Li, Wei Wang, Cheng-liang Zhu, Xing-hui Liu. HBV promotes its replication by up-regulating RAD51C gene expression. Scientific Reports 2024; 14(1) doi: 10.1038/s41598-024-53047-7
94
Henry L. Y. Chan, Yao Hu, Katharina Malinowsky, Kairat Madin, Konstantin Kroeniger, Jinlin Hou, Ashish Sharma. Prospective appraisal of clinical diagnostic algorithms for hepatocellular carcinoma surveillance in Chinese patients with chronic hepatitis B infection. Scientific Reports 2024; 14(1) doi: 10.1038/s41598-024-80257-w
95
Dabing Huang, Yinan Shen, Wei Zhang, Chengxiang Guo, Tingbo Liang, Xueli Bai. A preoperative nomogram predicts prognosis of patients with hepatocellular carcinoma after liver transplantation: a multicenter retrospective study. BMC Cancer 2021; 21(1) doi: 10.1186/s12885-021-07938-x
96
Z. I. Siddiqui, S. R. Farooqui, S. A. Azam, M. Afroz, S. Wajid, S. Parveen, S. N. Kazim. A comparative study of hepatitis B virus X protein mutants K130M, V131I and KV130/131MI to investigate their roles in fibrosis, cirrhosis and hepatocellular carcinoma. Journal of Viral Hepatitis 2017; 24(12) doi: 10.1111/jvh.12747
97
Krishnapriya Ramakrishnan, Sreeranjini Babu, Vineetha Shaji, Sowmya Soman, Anila Leelamma, Niyas Rehman, Rajesh Raju. Hepatitis B Virus Modulated Transcriptional Regulatory Map of Hepatic Cellular MicroRNAs. OMICS: A Journal of Integrative Biology 2023; 27(12) doi: 10.1089/omi.2023.0171
98
Suchandrima Ghosh, Anannya Chakraborty, Soma Banerjee. Persistence of Hepatitis B Virus Infection: A Multi-Faceted Player for Hepatocarcinogenesis. Frontiers in Microbiology 2021; 12 doi: 10.3389/fmicb.2021.678537
99
Hai Zhuang, Xiaoxia Ma, Xiaoyan Liu, Chao Li, Xinying Li, Ling Wu, Maofei Wen, Wenli Shi, Xiaozhou Yang. Hyaluronan-mediated motility receptor antisense RNA 1 promotes hepatitis B virus-related hepatocellular carcinoma progression by regulating miR-627-3p/High Mobility Group AT-hook 2 axis. Bioengineered 2022; 13(4) doi: 10.1080/21655979.2022.2054151
100
Behnaz Riazalhosseini, Zahurin Mohamed, Yamunah Devi Apalasamy, Noor Shafila Shafie, Rosmawati Mohamed. Interleukin-6 gene variants are associated with reduced risk of chronicity in hepatitis B virus infection in a Malaysian population. Biomedical Reports 2018;  doi: 10.3892/br.2018.1126
101
Shuaichen Liu, Samantha Koh, Caroline Lee. Hepatitis B Virus X Protein and Hepatocarcinogenesis. International Journal of Molecular Sciences 2016; 17(6) doi: 10.3390/ijms17060940
102
Taiyang Shi, Qinfang Hua, Zhipeng Ma, Qijun Lv. Downregulation of miR-200a-3p induced by hepatitis B Virus X (HBx) Protein promotes cell proliferation and invasion in HBV-infection-associated hepatocarcinoma. Pathology - Research and Practice 2017; 213(12) doi: 10.1016/j.prp.2017.10.020
103
Shringar Rao, Tanvir Hossain, Tokameh Mahmoudi. 3D human liver organoids: An in vitro platform to investigate HBV infection, replication and liver tumorigenesis. Cancer Letters 2021; 506 doi: 10.1016/j.canlet.2021.02.024
104
Jiyoung Lee, Kuen-Nan Tsai, Jing-hsiung James Ou. Viruses and Human Cancer. Recent Results in Cancer Research 2021; 217 doi: 10.1007/978-3-030-57362-1_3
105
Oscar Trejo‐Cerro, Martina Bergant Marušič, Justyna Broniarczyk. Ubiquitination dynamics in human tumour viruses: Viral infection, oncogenesis and antiviral therapy. The FEBS Journal 2026; 293(2) doi: 10.1111/febs.70224
106
Huijing Chen, Yi Zhang, Shuangshuang Ye, Qiong Wu, Youfen Lin, Kaiqin Sheng, Wannan Chen, Xinjian Lin, Xu Lin. Chromatin remodelling factor BAF155 protects hepatitis B virus X protein (HBx) from ubiquitin-independent proteasomal degradation. Emerging Microbes & Infections 2019; 8(1) doi: 10.1080/22221751.2019.1666661
107
Hui-Lin Wu, Tzu-Hung Hsiao, Pei-Jer Chen, Siao-Han Wong, Jia-Horng Kao, Ding-Shinn Chen, Jo-Yang Lu, Tzu-Pin Lu, Yidong Chen, Eric Y. Chuang, Hui-Chu Tu, Chun-Jen Liu. Liver Gene Expression Profiles Correlate with Virus Infection and Response to Interferon Therapy in Chronic Hepatitis B Patients. Scientific Reports 2016; 6(1) doi: 10.1038/srep31349
108
Guitao Xiao, Xiaoyun Huang, Tingxuan Huang, Zhixin Chen, Yuehong Huang, Rongfeng Huang, Xiaozhong Wang. Hepatitis B virus X protein differentially regulates the angiogenesis of Hepatocellular Carcinoma through p53-VEGF axis according to glucose levels. Annals of Hepatology 2024; 29(6) doi: 10.1016/j.aohep.2024.101543
109
Tetsuya Shimizu, Tomohiro Kanda, Takahiro Murokawa, Hideyuki Takata, Hiroyasu Furuki, Yuto Aoki, Mampei Kawashima, Toshiyuki Irie, Takashi Ono, Takahiro Haruna, Daigo Yoshimori, Kazuhiko Endo, Akira Hamaguchi, Hiroshi Yoshida, Yoichi Kawano, Satoshi Mizutani, Akira Matsushita, Masato Yoshioka, Nobuhiko Taniai, Junji Ueda. Hepatic resection in adolescent and young adult patients with hepatocellular carcinoma. World Journal of Clinical Oncology 2026; 17(5): 117168 doi: 10.5306/wjco.v17.i5.117168
110
Myeong-Eun Jegal, Seung-Youn Jung, Yu-Seon Han, Yung-Jin Kim. C-terminal truncated HBx reduces doxorubicin cytotoxicity via ABCB1 upregulation in Huh-7 hepatocellular carcinoma cells. BMB Reports 2019; 52(5) doi: 10.5483/BMBRep.2019.52.5.312
111
Bo Zhu, Jinju Wang, Hui Li, Xing Chen, Yong Zeng. Living or deceased organ donors in liver transplantation for hepatocellular carcinoma: a systematic review and meta-analysis. HPB 2019; 21(2) doi: 10.1016/j.hpb.2018.11.004
112
R. Salpini, M. Surdo, M.F. Cortese, G.A. Palumbo, L. Carioti, G. Cappiello, A. Spanò, P. Trimoulet, H. Fleury, J. Vecchiet, C. Pasquazzi, C. Mirabelli, R. Scutari, A. Sacco, M. Alkhatib, G. Missale, S. Francioso, L. Sarmati, M. Andreoni, M. Angelico, F. Ceccherini-Silberstein, M. Levrero, C.F. Perno, L. Belloni, V. Svicher. The novel HBx mutation F30V correlates with hepatocellular carcinoma in vivo, reduces hepatitis B virus replicative efficiency and enhances anti-apoptotic activity of HBx N terminus in vitro. Clinical Microbiology and Infection 2019; 25(7) doi: 10.1016/j.cmi.2018.11.017
113
Saisai Zhang, Lung-Yi Mak, Man-Fung Yuen, Wai-Kay Seto. Mechanisms of hepatocellular carcinoma and cirrhosis development in concurrent steatotic liver disease and chronic hepatitis B. Clinical and Molecular Hepatology 2025; 31(Suppl) doi: 10.3350/cmh.2024.0837
114
Tao Wan, Zhao Lei, Biao Tu, Tianyin Wang, Jiale Wang, Feizhou Huang. NEDD4 Induces K48-Linked Degradative Ubiquitination of Hepatitis B Virus X Protein and Inhibits HBV-Associated HCC Progression. Frontiers in Oncology 2021; 11 doi: 10.3389/fonc.2021.625169
115
Mengxi Xiu, Xiaohong Zeng, Renfeng Shan, Wu Wen, Jianfeng Li, Renhua Wan. The oncogenic role of HBXIP. Biomedicine & Pharmacotherapy 2021; 133 doi: 10.1016/j.biopha.2020.111045
116
Alexis Brantly, Kyle Yeakle, Michael J Bouchard, Peter J Gaskill, Michael R Nonnemacher. The role of liver macrophages in viral liver pathogenesis. Journal of Leukocyte Biology 2025; 117(9) doi: 10.1093/jleuko/qiaf088
117
Ines Dhifallah, Marwa Khedhiri, Anissa Chouikha, Ghassen Kharroubi, Walid Hammami, Amel Sadraoui, Mohamed Msaddek Azzouz, Nadia Maamouri, Tahar Khalfallah, Henda Triki, Pascal Pineau, Olfa Bahri. Hepatitis viruses take advantage of traditional practices to increase the burden of hepatocellular carcinoma in Tunisia. Archives of Virology 2020; 165(1) doi: 10.1007/s00705-019-04440-5
118
Ziniu Ding, Zhaoru Dong, Zhiqiang Chen, Jianguo Hong, Lunjie Yan, Haichao Li, Shengyu Yao, Yuchuan Yan, Yafei Yang, Chuncheng Yang, Tao Li. Viral Status and Efficacy of Immunotherapy in Hepatocellular Carcinoma: A Systematic Review With Meta-Analysis. Frontiers in Immunology 2021; 12 doi: 10.3389/fimmu.2021.733530
119
Qiuyue Zhang, Jinchen Liu, Haifeng Lin, Bo Lin, Mingyue Zhu, Mengsen Li. Glucose metabolism reprogramming promotes immune escape of hepatocellular carcinoma cells. Exploration of Targeted Anti-tumor Therapy 2023;  doi: 10.37349/etat.2023.00149
120
Y. V. Panasiuk, N. V. Vlasenko, N. S. Churilova, V. V. Klushkina, D. V. Dubodelov, E. N. Kudryavtseva, M. I. Korabelnikova, Z. S. Rodionova, T. A. Semenenko, S. N. Kuzin, V. G. Akimkin. Modern views on the role of <i>X</i> gene of the hepatitis B virus (<i>Hepadnaviridae: Orthohepadnavirus: Hepatitis B virus</i>) in the pathogenesis of the infection it causes. Problems of Virology 2022; 67(1) doi: 10.36233/0507-4088-84
121
Sung Hee Park, Sun-Min Lee, Young-Joon Kim, Sangsoo Kim. ChARM: Discovery of combinatorial chromatin modification patterns in hepatitis B virus X-transformed mouse liver cancer using association rule mining. BMC Bioinformatics 2016; 17(S16) doi: 10.1186/s12859-016-1307-z
122
Kavita Goyal, Muhammad Afzal, Ashok Kumar Bishoyi, R. Roopashree, Suman Saini, R. S. K. Sharma, Piyus Kumar Pathak, Ashish Singh Chauhan, Surendar Aravindhan, Mohd Imran, Abida Abida Abida. Ubiquitin-specific proteases in hepatitis: bridging molecular mechanisms and therapeutic potential. Egyptian Liver Journal 2025; 15(1) doi: 10.1186/s43066-025-00434-y
123
Jun Wang, Xiaoxue Yuan, Yun Wang, Yu Zhang, Ming Han, Hongping Lu, Shunai Liu, Yang Zhang, Feilin Ge, Yan Liu, Jun Cheng. PreS1BP mediates inhibition of Hepatitis B virus replication by promoting HBx protein degradation. Virus Research 2024; 341 doi: 10.1016/j.virusres.2024.199326
124
Zhouhua Hou, Jun Quan. Hepatitis B virus X protein increases microRNA-21 expression and accelerates the development of hepatoma via the phosphatase and tensin homolog/phosphoinositide 3-kinase/protein kinase B signaling pathway. Molecular Medicine Reports 2017; 15(5) doi: 10.3892/mmr.2017.6363
125
Carolina González, David Tabernero, Maria Francesca Cortese, Josep Gregori, Rosario Casillas, Mar Riveiro-Barciela, Cristina Godoy, Sara Sopena, Ariadna Rando, Marçal Yll, Rosa Lopez-Martinez, Josep Quer, Rafael Esteban, Maria Buti, Francisco Rodríguez-Frías. Detection of hyper-conserved regions in hepatitis B virus X gene potentially useful for gene therapy. World Journal of Gastroenterology 2018; 24(19): 2095-2107 doi: 10.3748/wjg.v24.i19.2095
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