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For: Hai H, Tamori A, Kawada N. Role of hepatitis B virus DNA integration in human hepatocarcinogenesis. World J Gastroenterol 2014; 20(20): 6236-6243 [PMID: 24876744 DOI: 10.3748/wjg.v20.i20.6236]
URL: https://www.wjgnet.com/1007-9327/full/v20/i20/6236.htm
Number Citing Articles
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Selena Y. Lin, Adam Zhang, Jessica Lian, Jeremy Wang, Ting-Tsung Chang, Yih-Jyh Lin, Wei Song, Ying-Hsiu Su. Recurrent HBV Integration Targets as Potential Drivers in Hepatocellular CarcinomaCells 2021; 10(6): 1294 doi: 10.3390/cells10061294
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Cheng Peng, Mengji Lu, Dongliang Yang. CRISPR/Cas9-based tools for targeted genome editing and replication control of HBVVirologica Sinica 2015; 30(5): 317 doi: 10.1007/s12250-015-3660-x
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Jian-jun Li, Jie Luo, Jing-ning Lu, Xiao-na Liang, Yi-huan Luo, Yong-ru Liu, Jie Yang, Hua Ding, Gui-hui Qin, Li-hua Yang, Yi-wu Dang, Hong Yang, Gang Chen. Relationship between TRAF6 and deterioration of HCC: an immunohistochemical and in vitro studyCancer Cell International 2016; 16(1) doi: 10.1186/s12935-016-0352-z
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Tian-Ying Zhang, Hong-Ying Chen, Jia-Li Cao, Hua-Long Xiong, Xiao-Bing Mo, Tian-Liang Li, Xiao-Zhen Kang, Jing-Hua Zhao, Bo Yin, Xiang Zhao, Cheng-Hao Huang, Quan Yuan, Ding Xue, Ning-Shao Xia, Y. Adam Yuan. Structural and functional analyses of hepatitis B virus X protein BH3-like domain and Bcl-xL interactionNature Communications 2019; 10(1) doi: 10.1038/s41467-019-11173-1
5
Subhayan Das, Moumita Kundu, Bikash Chandra Jena, Mahitosh Mandal. Biomaterials for 3D Tumor Modeling2020; : 607 doi: 10.1016/B978-0-12-818128-7.00025-3
6
Ping An, Jinghang Xu, Yanyan Yu, Cheryl A. Winkler. Host and Viral Genetic Variation in HBV-Related Hepatocellular CarcinomaFrontiers in Genetics 2018; 9 doi: 10.3389/fgene.2018.00261
7
Gulsum Ozlem Elpek. Molecular pathways in viral hepatitis-associated liver carcinogenesis: An updateWorld Journal of Clinical Cases 2021; 9(19): 4890-4917 doi: 10.12998/wjcc.v9.i19.4890
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Tarek Mohamed Kamal Motawi, Dina Sabry, Nagwa Ibrahim Shehata, Mira Magdy William, Atef Tadros Fahim. Impact of FOXP1 rs2687201 genetic variant on the susceptibility to HCV‐related hepatocellular carcinoma in EgyptiansJournal of Biochemical and Molecular Toxicology 2022; 36(3) doi: 10.1002/jbt.22965
9
Francesca Pezzuto, Luigi Buonaguro, Franco M. Buonaguro, Maria Lina Tornesello. Frequency and geographic distribution of TERT promoter mutations in primary hepatocellular carcinomaInfectious Agents and Cancer 2017; 12(1) doi: 10.1186/s13027-017-0138-5
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Mehdi Fazlalipour, Zohreh-al-sadat Ghoreshi, Hamid Reza Molaei, Nasir Arefinia. The Role of DNA Viruses in Human CancerCancer Informatics 2023; 22 doi: 10.1177/11769351231154186
11
Michelle Hong, Antonio Bertoletti. Tolerance and immunity to pathogens in early life: insights from HBV infectionSeminars in Immunopathology 2017; 39(6): 643 doi: 10.1007/s00281-017-0641-1
12
Canbiao Wu, Xiaofang Guo, Mengyuan Li, Jingxian Shen, Xiayu Fu, Qingyu Xie, Zeliang Hou, Manman Zhai, Xiaofan Qiu, Zifeng Cui, Hongxian Xie, Pengmin Qin, Xuchu Weng, Zheng Hu, Jiuxing Liang. DeepHBV: a deep learning model to predict hepatitis B virus (HBV) integration sitesBMC Ecology and Evolution 2021; 21(1) doi: 10.1186/s12862-021-01869-8
13
Vahdat Poortahmasebi, Seyed Moayed Alavian, Azam Ghaziasadi, Arezou Azadi, Mohsen Nasiri Toosi, Seyed Mohammad Jazayeri. Detection and Quantification of Hepatitis B Virus Genomes in Peripheral Blood Mononuclear Cells of Chronic Hepatitis B Virus Infection, Cirrhosis, and Hepatocellular Carcinoma PatientsHepatitis Monthly 2022; 21(10) doi: 10.5812/hepatmon.120982
14
Andoni Gómez-Moreno, Urtzi Garaigorta. Hepatitis B Virus and DNA Damage Response: Interactions and Consequences for the InfectionViruses 2017; 9(10): 304 doi: 10.3390/v9100304
15
Satoru Hagiwara, Naoshi Nishida, Ah-Mee Park, Yoriaki Komeda, Toshiharu Sakurai, Tomohiro Watanabe, Masatoshi Kudo. Contribution of C1485T mutation in the HBx gene to human and murine hepatocarcinogenesisScientific Reports 2017; 7(1) doi: 10.1038/s41598-017-10570-0
16
Danielle Wendel, Karen F. Murray. Management of Chronic Hepatitis B in ChildrenCurrent Hepatology Reports 2017; 16(2): 81 doi: 10.1007/s11901-017-0338-x
17
Patrizia Ballerini, Annalisa Contursi, Annalisa Bruno, Matteo Mucci, Stefania Tacconelli, Paola Patrignani. Inflammation and Cancer: From the Development of Personalized Indicators to Novel Therapeutic StrategiesFrontiers in Pharmacology 2022; 13 doi: 10.3389/fphar.2022.838079
18
Meghri Katerji, Antonella Bertucci, Valery Filippov, Marcelo Vazquez, Xin Chen, Penelope J. Duerksen-Hughes. Proton-induced DNA damage promotes integration of foreign plasmid DNA into human genomeFrontiers in Oncology 2022; 12 doi: 10.3389/fonc.2022.928545
19
Natalia Freitas, Tetyana Lukash, Sumedha Gunewardena, Benjamin Chappell, Betty L. Slagle, Severin O. Gudima, Rozanne M. Sandri-Goldin. Relative Abundance of Integrant-Derived Viral RNAs in Infected Tissues Harvested from Chronic Hepatitis B Virus CarriersJournal of Virology 2018; 92(10) doi: 10.1128/JVI.02221-17
20
Tarek Mohamed Kamal Motawi, Nermin Abdel Hamid Sadik, Dina Sabry, Nancy Nabil Shahin, Sally Atef Fahim. rs2267531, a promoter SNP within glypican-3 gene in the X chromosome, is associated with hepatocellular carcinoma in EgyptiansScientific Reports 2019; 9(1) doi: 10.1038/s41598-019-43376-3
21
Janos Minarovits, Hans Helmut Niller. Truncated oncoproteins of retroviruses and hepatitis B virus: A lesson in contrastsInfection, Genetics and Evolution 2019; 73: 342 doi: 10.1016/j.meegid.2019.05.020
22
Dong-Mei Cai, Fan-Biao Mei, Chao-Jun Zhang, San-Chun An, Rui-Bo Lv, Guan-Hua Ren, Chan-Chan Xiao, Long Long, Tian-Ren Huang, Wei Deng. The Abnormal Proliferation of Hepatocytes is Associated with MC-LR and C-Terminal Truncated HBX Synergistic Disturbance of the Redox BalanceJournal of Hepatocellular Carcinoma 2022; : 1229 doi: 10.2147/JHC.S389574
23
Johan Ringlander, Catarina Skoglund, Kasthuri Prakash, Maria E. Andersson, Simon B. Larsson, Ka‐Wei Tang, Gustaf E. Rydell, Sanna Abrahamsson, Maria Castedal, Heléne Norder, Kristoffer Hellstrand, Magnus Lindh. Deep sequencing of liver explant transcriptomes reveals extensive expression from integrated hepatitis B virus DNAJournal of Viral Hepatitis 2020; 27(11): 1162 doi: 10.1111/jvh.13356
24
Kaitao Zhao, Andrew Liu, Yuchen Xia. Insights into Hepatitis B Virus DNA Integration-55 Years after Virus DiscoveryThe Innovation 2020; 1(2): 100034 doi: 10.1016/j.xinn.2020.100034
25
Fumio Itoh, Yoshiyuki Watanabe, Ritsuko Oikawa, Hiroshi Yotsuyanagi, Hiroyuki Yamamoto. Hepatocarcinogenesis by the integration of hepatitis B virus DNA and the development of its detection systemElectrophoresis Letters 2015; 59(2): 58 doi: 10.2198/electroph.59.58
26
Lena Allweiss, Tassilo Volz, Katja Giersch, Janine Kah, Giuseppina Raffa, Joerg Petersen, Ansgar W Lohse, Concetta Beninati, Teresa Pollicino, Stephan Urban, Marc Lütgehetmann, Maura Dandri. Proliferation of primary human hepatocytes and prevention of hepatitis B virus reinfection efficiently deplete nuclear cccDNA in vivoGut 2018; 67(3): 542 doi: 10.1136/gutjnl-2016-312162
27
Fan-Yun Kong, Xiao Wei, Kai Zhou, Wei Hu, Yan-Bo Kou, Hong-Juan You, Xiao-Mei Liu, Kui-Yang Zheng, Ren-Xian Tang, Jason Blackard. Bioinformatics Analysis Reveals Distinct Molecular Characteristics of Hepatitis B-Related Hepatocellular Carcinomas from Very Early to Advanced Barcelona Clinic Liver Cancer StagesPLOS ONE 2016; 11(7): e0158286 doi: 10.1371/journal.pone.0158286
28
Zhao-Shan Niu, Xiao-Jun Niu, Wen-Hong Wang. Genetic alterations in hepatocellular carcinoma: An updateWorld Journal of Gastroenterology 2016; 22(41): 9069-9095 doi: 10.3748/wjg.v22.i41.9069
29
Chiao‐Ling Li, Chen‐Yu Li, You‐Yu Lin, Ming‐Chih Ho, Ding‐Shinn Chen, Pei‐Jer Chen, Shiou‐Hwei Yeh. Androgen Receptor Enhances Hepatic Telomerase Reverse Transcriptase Gene Transcription After Hepatitis B Virus Integration or Point Mutation in Promoter RegionHepatology 2019; 69(2): 498 doi: 10.1002/hep.30201
30
Maria Lina Tornesello, Luigi Buonaguro, Francesco Izzo, Franco M. Buonaguro. Molecular alterations in hepatocellular carcinoma associated with hepatitis B and hepatitis C infectionsOncotarget 2016; 7(18): 25087 doi: 10.18632/oncotarget.7837
31
Po-Ming Wang, Na-Na Chung, Wei-Chung Hsu, Feng-Ling Chang, Chin-Jyh Jang, Marta Scorsetti. Stereotactic body radiation therapy in hepatocellular carcinoma: Optimal treatment strategies based on liver segmentation and functional hepatic reserveReports of Practical Oncology & Radiotherapy 2015; 20(6): 417 doi: 10.1016/j.rpor.2015.03.005
32
Hao Li, Chunyu Sheng, Shan Wang, Lang Yang, Yuan Liang, Yong Huang, Hongbo Liu, Peng Li, Chaojie Yang, Xiaoxia Yang, Leili Jia, Jing Xie, Ligui Wang, Rongzhang Hao, Xinying Du, Dongping Xu, Jianjun Zhou, Mingzhen Li, Yansong Sun, Yigang Tong, Qiao Li, Shaofu Qiu, Hongbin Song. Removal of Integrated Hepatitis B Virus DNA Using CRISPR-Cas9Frontiers in Cellular and Infection Microbiology 2017; 7 doi: 10.3389/fcimb.2017.00091
33
Saidu Kamara, Yanru Guo, Shanshan Mao, Xiaoxian Ye, Qingfeng Li, Maolin Zheng, Jinshun Zhu, Jing Zhang, Wangqi Du, Jun Chen, Shanli Zhu, Lifang Zhang. Novel EBV LMP1 C-terminal domain binding affibody molecules as potential agents for in vivo molecular imaging diagnosis of nasopharyngeal carcinomaApplied Microbiology and Biotechnology 2021; 105(19): 7283 doi: 10.1007/s00253-021-11559-6
34
Mingming Zhang, Han Chen, Huan Liu, Hong Tang. The impact of integrated hepatitis B virus DNA on oncogenesis and antiviral therapyBiomarker Research 2024; 12(1) doi: 10.1186/s40364-024-00611-y
35
Chaojun Zhang, Chanchan Xiao, Guanhua Ren, Dongmei Cai, Long Long, Jilin Li, Kezhi Li, Yanping Tang, Tianren Huang, Wei Deng. C-terminal-truncated hepatitis B virus X protein promotes hepatocarcinogenesis by activating the MAPK pathwayMicrobial Pathogenesis 2021; 159: 105136 doi: 10.1016/j.micpath.2021.105136
36
Suchandrima Ghosh, Anannya Chakraborty, Soma Banerjee. Persistence of Hepatitis B Virus Infection: A Multi-Faceted Player for HepatocarcinogenesisFrontiers in Microbiology 2021; 12 doi: 10.3389/fmicb.2021.678537
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Arvin Medhat, Alla Arzumanyan, Mark A. Feitelson. Hepatitis B x antigen (HBx) is an important therapeutic target in the pathogenesis of hepatocellular carcinomaOncotarget 2021; 12(24): 2421 doi: 10.18632/oncotarget.28077
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Yongjun Tian, Jing-hsiung James Ou. Genetic and epigenetic alterations in hepatitis B virus-associated hepatocellular carcinomaVirologica Sinica 2015; 30(2): 85 doi: 10.1007/s12250-015-3582-7
39
Yun Ji, Yue Yin, Weizhen Zhang. Integrated Bioinformatic Analysis Identifies Networks and Promising Biomarkers for Hepatitis B Virus-Related Hepatocellular CarcinomaInternational Journal of Genomics 2020; 2020: 1 doi: 10.1155/2020/2061024
40
Jiang Guo, Xue-Song Gao. Prediction models for development of hepatocellular carcinoma in chronic hepatitis B patientsWorld Journal of Clinical Cases 2021; 9(14): 3238-3251 doi: 10.12998/wjcc.v9.i14.3238
41
Jiyoung Lee, Kuen-Nan Tsai, Jing-hsiung James Ou. Viruses and Human CancerRecent Results in Cancer Research 2021; 217: 47 doi: 10.1007/978-3-030-57362-1_3
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Yuya Kato, Hirotaka Tabata, Kumiko Sato, Mariko Nakamura, Izumu Saito, Tomoko Nakanishi. Adenovirus Vectors Expressing Eight Multiplex Guide RNAs of CRISPR/Cas9 Efficiently Disrupted Diverse Hepatitis B Virus Gene Derived from Heterogeneous PatientInternational Journal of Molecular Sciences 2021; 22(19): 10570 doi: 10.3390/ijms221910570
43
Xuan Luo, Yao Huang, Yanmeng Chen, Zeng Tu, Jieli Hu, John E. Tavis, Ailong Huang, Yuan Hu, Michael J. Bouchard. Association of Hepatitis B Virus Covalently Closed Circular DNA and Human APOBEC3B in Hepatitis B Virus-Related Hepatocellular CarcinomaPLOS ONE 2016; 11(6): e0157708 doi: 10.1371/journal.pone.0157708
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Noemi Linden, R. Brad Jones. Potential multi-modal effects of provirus integration on HIV-1 persistence: lessons from other virusesTrends in Immunology 2022; 43(8): 617 doi: 10.1016/j.it.2022.06.001
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Yi-Fan Lian, Yan-Lin Huang, Jia-Liang Wang, Mei-Hai Deng, Tian-Liang Xia, Mu-Sheng Zeng, Min-Shan Chen, Hong-Bo Wang, Yue-Hua Huang. Anillin is required for tumor growth and regulated by miR-15a/miR-16-1 in HBV-related hepatocellular carcinomaAging 2018; 10(8): 1884 doi: 10.18632/aging.101510
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Aaron J. Smith, John Oertle, Dino Prato. Cancer and Infectious CausesOpen Journal of Medical Microbiology 2014; 4(03): 161 doi: 10.4236/ojmm.2014.43019
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Chao Zhang, Peng Liu, Chuanbao Zhang. Hepatitis B Virus X Protein Up-Regulates Alpha-Fetoprotein to Promote Hepatocellular Carcinoma by Targeting miR-1236 and miR-1270SSRN Electronic Journal 2019;  doi: 10.2139/ssrn.3356837
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Lingyun Guo, Zhenjiang Wang, Yuanyuan Du, Jie Mao, Junqiang Zhang, Zeyuan Yu, Jiwu Guo, Jun Zhao, Huinian Zhou, Haitao Wang, Yanmei Gu, Yumin Li. Random-forest algorithm based biomarkers in predicting prognosis in the patients with hepatocellular carcinomaCancer Cell International 2020; 20(1) doi: 10.1186/s12935-020-01274-z
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Jinyu Zhang, Yi Zhang, Sushant Khanal, Dechao Cao, Juan Zhao, Xindi Dang, Lam Ngoc Thao Nguyen, Madison Schank, Xiao Y. Wu, Yong Jiang, Shunbin Ning, Ling Wang, Mohamed El Gazzar, Jonathan P. Moorman, Haitao Guo, Zhi Q. Yao. Synthetic gRNA/Cas9 ribonucleoprotein targeting HBV DNA inhibits viral replicationJournal of Medical Virology 2023; 95(7) doi: 10.1002/jmv.28952
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Nirmala Subramaniam, Pugazhendhi Kannan, Ashokkumar K, Devaki Thiruvengadam. Hepatoprotective effect of boldine against diethylnitrosamine‐induced hepatocarcinogenesis in wistar ratsJournal of Biochemical and Molecular Toxicology 2019; 33(12) doi: 10.1002/jbt.22404
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Young-Man Lee, Soojin Kim, Ran-Young Park, Yeon-Soo Kim. Hepatitis B Virus-X Downregulates Expression of Selenium Binding Protein 1Viruses 2020; 12(5): 565 doi: 10.3390/v12050565
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Jordan Aldersley, David R. Lorenz, Vikas Misra, Hajime Uno, Dana Gabuzda. Increased risk of anal squamous cell carcinoma in HIV-positive men with prior hepatitis B virus infectionAIDS 2019; 33(1): 145 doi: 10.1097/QAD.0000000000002059
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Michelle Hong, Antonio Bertoletti. Viral Hepatitis in Children2019; : 115 doi: 10.1007/978-981-13-0050-9_8
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Sebastien Boucle, Leda Bassit, Maryam Ehteshami, Raymond F. Schinazi. Toward Elimination of Hepatitis B Virus Using Novel Drugs, Approaches, and Combined ModalitiesClinics in Liver Disease 2016; 20(4): 737 doi: 10.1016/j.cld.2016.07.001
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Izzet Mehmet Akcay, Seyma Katrinli, Kamil Ozdil, Gizem Dinler Doganay, Levent Doganay. Host genetic factors affecting hepatitis B infection outcomes: Insights from genome-wide association studiesWorld Journal of Gastroenterology 2018; 24(30): 3347-3360 doi: 10.3748/wjg.v24.i30.3347
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Barbara Grasiele Müller-Coan, Brunno Felipe Ramos Caetano, Joseph Stephen Pagano, Deilson Elgui de Oliveira. Cancer Progression Goes Viral: The Role of Oncoviruses in Aggressiveness of MalignanciesTrends in Cancer 2018; 4(7): 485 doi: 10.1016/j.trecan.2018.04.006
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Tibor Bakacs, Rifaat Safadi, Imre Kovesdi. Post-infection viral superinfection technology could treat HBV and HCV patients with unmet needsHepatology, Medicine and Policy 2018; 3(1) doi: 10.1186/s41124-017-0028-x
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Manoj Kumar Rajput. Mutations and methods of analysis of mutations in Hepatitis B virusAIMS Microbiology 2020; 6(4): 401 doi: 10.3934/microbiol.2020024
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Yanan Pang, Weixing Guo, Jiaqi Wang, Guixia Xu, Kai Cheng, Guangwen Cao, Mengchao Wu, Shuqun Cheng, Shanrong Liu. Gene copy number variations in the leukocyte genome of hepatocellular carcinoma patients with integrated hepatitis B virus DNAOncotarget 2016; 7(7): 8006 doi: 10.18632/oncotarget.6895
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Renumathy Dhanasekaran, Salome Bandoh, Lewis R. Roberts. Molecular pathogenesis of hepatocellular carcinoma and impact of therapeutic advancesF1000Research 2016; 5: 879 doi: 10.12688/f1000research.6946.1
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Dong Hyun Sinn, Geum-Youn Gwak, Juhee Cho, Seung Woon Paik, Byung Chul Yoo, Pierre Roques. Comparison of Clinical Manifestations and Outcomes between Hepatitis B Virus- and Hepatitis C Virus-Related Hepatocellular Carcinoma: Analysis of a Nationwide CohortPLoS ONE 2014; 9(11): e112184 doi: 10.1371/journal.pone.0112184
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Yikai Wang, Le Ma, Pengjun Xue, Bianni Qin, Ting Wang, Bo Li, Lina Wu, Liyan Zhao, Xiongtao Liu, Antonio Giovanni Solimando. Construction and Analysis of Hepatocellular Carcinoma Prognostic Model Based on Random ForestCanadian Journal of Gastroenterology and Hepatology 2023; 2023: 1 doi: 10.1155/2023/6707698
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Xiaobo Yang, Liangcai Wu, Jianzhen Lin, Anqiang Wang, Xueshuai Wan, Yan Wu, Simon C. Robson, Xinting Sang, Haitao Zhao. Distinct hepatitis B virus integration patterns in hepatocellular carcinoma and adjacent normal liver tissueInternational Journal of Cancer 2017; 140(6): 1324 doi: 10.1002/ijc.30547
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Yuchao Xia, Yun Liu, Minghua Deng, Ruibin Xi. Detecting virus integration sites based on multiple related sequencing data by VirTectBMC Medical Genomics 2019; 12(S1) doi: 10.1186/s12920-018-0461-8
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G.Y. Minuk, Y. Baruch. Hepatitis B viral infection of hepatic progenitor cells. Resolving unresolved questions?Medical Hypotheses 2016; 91: 24 doi: 10.1016/j.mehy.2016.04.011
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Michael Thomaschewski, Kristoffer Riecken, Ludmilla Unrau, Tassilo Volz, Kerstin Cornils, Harald Ittrich, Denise Heim, Henning Wege, Ercan Akgün, Marc Lütgehetmann, Jan Dieckhoff, Michael Köpke, Maura Dandri, Daniel Benten, Boris Fehse. Multi-color RGB marking enables clonality assessment of liver tumors in a murine xenograft modelOncotarget 2017; 8(70): 115582 doi: 10.18632/oncotarget.23312
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Abdul Arif Khan, Vijay Nema, Mohd. Tashfeen Ashraf. Host-microbiota interactions and oncogenesis: Crosstalk and its implications in etiologyMicrobial Pathogenesis 2023; 178: 106063 doi: 10.1016/j.micpath.2023.106063
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Chen Huan-wei, Liao Shan, Lau Wan-Yee, Wang Feng-jie, Deng Fei-wen, Lai Eric Chun-hung, Zhen Zuo-jun. Prognostic impact of hepatic resection for hepatocellular carcinoma: The role of the surgeon in achieving R0 resection – A retrospective cohort studyInternational Journal of Surgery 2015; 13: 297 doi: 10.1016/j.ijsu.2014.12.017
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Nour Y.S. Yassin, Sameh F. AbouZid, Asmaa M. El-Kalaawy, Tarek M. Ali, Mazen M. Almehmadi, Osama M. Ahmed. Silybum marianum total extract, silymarin and silibinin abate hepatocarcinogenesis and hepatocellular carcinoma growth via modulation of the HGF/c-Met, Wnt/β-catenin, and PI3K/Akt/mTOR signaling pathwaysBiomedicine & Pharmacotherapy 2022; 145: 112409 doi: 10.1016/j.biopha.2021.112409
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Wai-Kay Seto, Man-Fung Yuen. 'Immune tolerance' in HBV infection: danger lurksNature Reviews Gastroenterology & Hepatology 2016; 13(11): 627 doi: 10.1038/nrgastro.2016.145
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Uyen Ngoc Mui, Christopher T. Haley, Ramya Vangipuram, Stephen K. Tyring. Human oncoviruses: Mucocutaneous manifestations, pathogenesis, therapeutics, and preventionJournal of the American Academy of Dermatology 2019; 81(1): 23 doi: 10.1016/j.jaad.2018.10.072