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For: Quarleri J. Core promoter: A critical region where the hepatitis B virus makes decisions. World J Gastroenterol 2014; 20(2): 425-435 [PMID: 24574711 DOI: 10.3748/wjg.v20.i2.425]
URL: https://www.wjgnet.com/1007-9327/full/v20/i2/425.htm
Number Citing Articles
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Kai-Wen Li, Anna Kramvis, Shujia Liang, Xiang He, Qin-Yan Chen, Chao Wang, Qing-Li Yang, Li-Ping Hu, Hui-Hua Jia, Zhong-Liao Fang. Higher prevalence of cancer related mutations 1762T/1764A and PreS deletions in hepatitis B virus (HBV) isolated from HBV/HIV co-infected compared to HBV-mono-infected Chinese adultsVirus Research 2017; 227: 88 doi: 10.1016/j.virusres.2016.10.002
2
Shu-ying Fan, Shao-yuan Long, Jia-jun Liu, Wen-lu Zhang, Jie-li Hu. Nicotinamide N-Methyltransferase inhibits HBV replication by suppressing NR5A1 expression in vitroBiochemical and Biophysical Research Communications 2022; 614: 70 doi: 10.1016/j.bbrc.2022.04.122
3
Annika Jasmin Walter, Maarten A. van de Klundert, Stephanie Jung. Many Ways to Communicate—Crosstalk between the HBV-Infected Cell and Its EnvironmentPathogens 2022; 12(1): 29 doi: 10.3390/pathogens12010029
4
Baoxin Zhao, Hongxiu Qiao, Yan Zhao, Zhiyun Gao, Weijie Wang, Yan Cui, Jian Li, Zhanjun Guo, Xia Chuai, Sandra Chiu. HBV precore G1896A mutation promotes growth of hepatocellular carcinoma cells by activating ERK/MAPK pathwayVirologica Sinica 2023; 38(5): 680 doi: 10.1016/j.virs.2023.06.004
5
Hong Kim, Seoung-Ae Lee, Bum-Joon Kim. X region mutations of hepatitis B virus related to clinical severityWorld Journal of Gastroenterology 2016; 22(24): 5467-5478 doi: 10.3748/wjg.v22.i24.5467
6
Alessandro Loglio, Mauro Viganò, Pietro Lampertico. Novel Therapies That May Cure Chronic Hepatitis B VirusClinics in Liver Disease 2021; 25(4): 875 doi: 10.1016/j.cld.2021.07.001
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Farzaneh Salarnia, Emad Behboudi, Iraj Shahramian, Abdolvahab Moradi. Novel X gene point mutations in chronic hepatitis B and HBV related cirrhotic patientsInfection, Genetics and Evolution 2022; 97: 105186 doi: 10.1016/j.meegid.2021.105186
8
Kai-Henrik Peiffer, Catrina Spengler, Michael Basic, Bingfu Jiang, Lisa Kuhnhenn, Wiebke Obermann, Tobias Zahn, Mirco Glitscher, Alessandro Loglio, Floriana Facchetti, Gert Carra, Alica Kubesch, Johannes Vermehren, Viola Knop, Christiana Graf, Julia Dietz, Fabian Finkelmeier, Eva Herrmann, Jonel Trebicka, Arnold Grünweller, Stefan Zeuzem, Christoph Sarrazin, Pietro Lampertico, Eberhard Hildt. Quadruple mutation GCAC1809-1812TTCT acts as a biomarker in healthy European HBV carriersJCI Insight 2020; 5(22) doi: 10.1172/jci.insight.135833
9
Mi So Seong, Hyeon Jeong Hwang, Eun Ah Jang, Jeong Ah Jang, Wah Wah Aung, Yi Yi Kyaw, JaeHun Cheong. Core promoter mutation of nucleotides A1762T and G1764A of hepatitis B virus increases core promoter transactivation by hepatocyte nuclear factor 1Journal of Microbiology 2022; 60(10): 1039 doi: 10.1007/s12275-022-1675-1
10
Guillaume Giraud, Khadija El Achi, Fabien Zoulim, Barbara Testoni. Co-Transcriptional Regulation of HBV Replication: RNA Quality Also MattersViruses 2024; 16(4): 615 doi: 10.3390/v16040615
11
Ying Tang, Tianyi Ma, Shengnan Jia, Qian Zhang, Siqi Liu, Ling Qi, Lanlan Yang. The Mechanism of Interleukin-35 in Chronic Hepatitis BSeminars in Liver Disease 2021; 41(04): 516 doi: 10.1055/s-0041-1731708
12
Ayse Banu Demir, Domenico Benvenuto, Bilge Karacicek, Yasemin Erac, Silvia Spoto, Silvia Angeletti, Massimo Ciccozzi, Metiner Tosun. Implications of Possible HBV-Driven Regulation of Gene Expression in Stem Cell-like Subpopulation of Huh-7 Hepatocellular Carcinoma Cell LineJournal of Personalized Medicine 2022; 12(12): 2065 doi: 10.3390/jpm12122065
13
Min Zhu, Zi Liang, Jun Pan, Xing Zhang, Renyu Xue, Guangli Cao, Xiaolong Hu, Chengliang Gong. Hepatocellular carcinoma progression mediated by hepatitis B virus-encoded circRNA HBV_circ_1 through interaction with CDK1Molecular Therapy - Nucleic Acids 2021; 25: 668 doi: 10.1016/j.omtn.2021.08.011
14
Ellen Van Damme, Jolien Vanhove, Bryan Severyn, Lore Verschueren, Frederik Pauwels. The Hepatitis B Virus Interactome: A Comprehensive OverviewFrontiers in Microbiology 2021; 12 doi: 10.3389/fmicb.2021.724877
15
Jaime Morales-Romero, Gustavo Vargas, Rebeca García-Román. Occult HBV Infection: A Faceless Enemy in Liver Cancer DevelopmentViruses 2014; 6(4): 1590 doi: 10.3390/v6041590
16
Surya Agung Priyambada, Ryo Misaki, Toru Okamoto, Takao Ohashi, Keiji Ueda, Yoshiharu Matsuura, Kazuhito Fujiyama. St6gal1 knockdown alters HBV life cycle in HepAD38 cellsBiochemical and Biophysical Research Communications 2018; 503(3): 1841 doi: 10.1016/j.bbrc.2018.07.124
17
Yang Liu, Dmytro Kornyeyev, Lindsey May, Dong Han, Thomas Aeschbacher, Silvia Chang, Ross Martin, Hongmei Mo, Becket Feierbach, J.-H. James Ou. Establishment and Characterization of an HBV Viral Spread and Infectious System following Long-Term Passage of an HBV Clinical Isolate in the Primary Human Hepatocyte and Fibroblast Coculture SystemJournal of Virology 2022; 96(18) doi: 10.1128/jvi.00849-22
18
Kübra Altinel, Kosuke Hashimoto, Yu Wei, Christine Neuveut, Ishita Gupta, Ana Maria Suzuki, Alexandre Dos Santos, Pierrick Moreau, Tian Xia, Soichi Kojima, Sachi Kato, Yasuhiro Takikawa, Isao Hidaka, Masahito Shimizu, Tomokazu Matsuura, Akihito Tsubota, Hitoshi Ikeda, Sumiko Nagoshi, Harukazu Suzuki, Marie-Louise Michel, Didier Samuel, Marie Annick Buendia, Jamila Faivre, Piero Carninci, G. McFadden. Single-Nucleotide Resolution Mapping of Hepatitis B Virus Promoters in Infected Human Livers and Hepatocellular CarcinomaJournal of Virology 2016; 90(23): 10811 doi: 10.1128/JVI.01625-16
19
Yuan Li, Masahiko Ito, Suofeng Sun, Takeshi Chida, Kenji Nakashima, Tetsuro Suzuki. LUC7L3/CROP inhibits replication of hepatitis B virus via suppressing enhancer II/basal core promoter activityScientific Reports 2016; 6(1) doi: 10.1038/srep36741
20
Xia-Fei Wei, Shu-Ying Fan, Yu-Wei Wang, Shan Li, Shao-Yuan Long, Chun-Yang Gan, Jie Li, Yu-Xue Sun, Lin Guo, Pei-Yun Wang, Xue Yang, Jin-Lan Wang, Jing Cui, Wen-Lu Zhang, Ai-Long Huang, Jie-Li Hu. Identification of STAU1 as a regulator of HBV replication by TurboID-based proximity labelingiScience 2022; 25(6): 104416 doi: 10.1016/j.isci.2022.104416
21
Shivaksh Ahluwalia, Divya Choudhary, Purnima Tyagi, Vijay Kumar, Perumal Vivekanandan. Vitamin D signaling inhibits HBV activity by directly targeting the HBV core promoterJournal of Biological Chemistry 2021; 297(4): 101233 doi: 10.1016/j.jbc.2021.101233
22
Kai O. Hensel, Julio C. Rendon, Maria‐Cristina Navas, Marianne G. Rots, Jan Postberg. Virus–host interplay in hepatitis B virus infection and epigenetic treatment strategiesThe FEBS Journal 2017; 284(21): 3550 doi: 10.1111/febs.14094
23
Di Yang, Renyun Tian, Rilin Deng, Binbin Xue, Shun Liu, Luoling Wang, Huiyi Li, Qian Liu, Mengyu Wan, Songqing Tang, Xiaohong Wang, Haizhen Zhu, Tao Deng. The dual functions of KDM7A in HBV replication and immune microenvironmentMicrobiology Spectrum 2023; 11(5) doi: 10.1128/spectrum.01641-23
24
Zeineb Belaiba, Kaouther Ayouni, Mariem Gdoura, Wafa Kammoun Rebai, Henda Touzi, Amel Sadraoui, Walid Hammemi, Lamia Yacoubi, Salwa Abdelati, Lamine Hamzaoui, Mohamed Msaddak Azzouz, Anissa Chouikha, Henda Triki. Whole genome analysis of hepatitis B virus before and during long-term therapy in chronic infected patients: Molecular characterization, impact on treatment and liver disease progressionFrontiers in Microbiology 2022; 13 doi: 10.3389/fmicb.2022.1020147
25
Kuen-Nan Tsai, Chin-Liew Chong, Yu-Chi Chou, Chien-Chiao Huang, Yi-Ling Wang, Shao-Win Wang, Mong-Liang Chen, Chun-Hong Chen, Chungming Chang, J.-H. J. Ou. Doubly Spliced RNA of Hepatitis B Virus Suppresses Viral Transcription via TATA-Binding Protein and Induces Stress Granule AssemblyJournal of Virology 2015; 89(22): 11406 doi: 10.1128/JVI.00949-15
26
Zhonghua Zhao, Yuwei Tang, Qinglv Wei, Huatang Zhang. Establishment of A New HBV Cell Culture Model by Covalently Closed Circular DNA Direct TransfectIOP Conference Series: Earth and Environmental Science 2021; 632(3): 032023 doi: 10.1088/1755-1315/632/3/032023
27
Ayako Sedohara, Kazuaki Takahashi, Keiko Arai, Kotaro Arizono, Khulan Tuvshinjargal, Makoto Saito, Fumio Nakahara, Takeya Tsutsumi, Kazuhiko Ikeuchi, Eisuke Adachi, Hiroshi Yotsuyanagi. Characterization of mutations in hepatitis B virus DNA isolated from Japanese HBsAg-positive blood donors in 2021 and 2022Archives of Virology 2024; 169(5) doi: 10.1007/s00705-024-06016-4
28
Ying Zhong, Dong-Ling Liu, Mohamed Morsi. M. Ahmed, Peng-Hao Li, Xiao-Ling Zhou, Qing-Dong Xie, Xiao-Qing Xu, Ting-Ting Han, Zhi-Wei Hou, Chen-Yao Zhong, Ji-Hua Huang, Fei Zeng, Tian-Hua Huang. Host genes regulate transcription of sperm-introduced hepatitis B virus genes in embryoReproductive Toxicology 2017; 73: 158 doi: 10.1016/j.reprotox.2017.08.009
29
Magda Rybicka, Krzysztof Piotr Bielawski. Recent Advances in Understanding, Diagnosing, and Treating Hepatitis B Virus InfectionMicroorganisms 2020; 8(9): 1416 doi: 10.3390/microorganisms8091416
30
Hepatitis B virus preCore/Core region variability in pregnant women in the Republic of GuineaJournal of microbiology, epidemiology and immunobiology 2024; 101(1): 61 doi: 10.36233/0372-9311-447
31
Vanessa Meier-Stephenson, William T. R. Bremner, Chimone S. Dalton, Guido Van Marle, Carla S. Coffin, Trushar R. Patel. Comprehensive Analysis of Hepatitis B Virus Promoter Region MutationsViruses 2018; 10(11): 603 doi: 10.3390/v10110603
32
Elham Shirvani-Dastgerdi, Benjamin Y. Winer, Toni Celià-Terrassa, Yibin Kang, David Tabernero, Eray Yagmur, Francisco Rodríguez-Frías, Josep Gregori, Tom Luedde, Christian Trautwein, Alexander Ploss, Frank Tacke. Selection of the highly replicative and partially multidrug resistant rtS78T HBV polymerase mutation during TDF-ETV combination therapyJournal of Hepatology 2017; 67(2): 246 doi: 10.1016/j.jhep.2017.03.027
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Manoj Kumar Rajput. Mutations and methods of analysis of mutations in Hepatitis B virusAIMS Microbiology 2020; 6(4): 401 doi: 10.3934/microbiol.2020024
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Jie Wang, Hongxin Huang, Yongzhen Liu, Ran Chen, Ying Yan, Shu Shi, Jingyuan Xi, Jun Zou, Guangxin Yu, Xiaoyu Feng, Fengmin Lu. Hepatitis B Virus InfectionAdvances in Experimental Medicine and Biology 2020; 1179: 17 doi: 10.1007/978-981-13-9151-4_2
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Yaqin Peng, Baoming Liu, Jinlin Hou, Jian Sun, Ran Hao, Kuanhui Xiang, Ling Yan, Jiangbo Zhang, Hui Zhuang, Tong Li. Naturally Occurring Deletions/Insertions in HBV Core Promoter Tend to Decrease in Hepatitis B e Antigen-Positive Chronic Hepatitis B Patients during Antiviral TherapyAntiviral Therapy 2015; 20(6): 623 doi: 10.3851/IMP2955
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SUPIANA DIAN NURTJAHYANI, RETNO HANDAJANI. Genotype of Hepatitis B Virus Coinfection in Typhoid PatientsMicrobiology Indonesia 2015; 9(3): 136 doi: 10.5454/mi.9.3.6
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Julieta Trinks, Sebastián Marciano, Isabella Esposito, Alejandra Franco, Maria Florencia Mascardi, Manuel Mendizabal, Beatriz Livellara, Diego Arrigo, Pablo Calzetta, Claudia Vujacich, Diego Giunta, Adrián Gadano, Diego Flichman. The genetic variability of hepatitis B virus subgenotype F1b precore/core gene is related to the outcome of the acute infectionVirus Research 2020; 277: 197840 doi: 10.1016/j.virusres.2019.197840
38
Hyein Jeong, Dong Hyun Kim, Yu-Min Choi, HyeLim Choi, Donghyun Kim, Bum-Joon Kim. rt269I Type of Hepatitis B Virus (HBV) Polymerase versus rt269L Is More Prone to Mutations within HBV Genome in Chronic Patients Infected with Genotype C2: Evidence from Analysis of Full HBV Genotype C2 GenomeMicroorganisms 2021; 9(3): 601 doi: 10.3390/microorganisms9030601
39
Rajesh Kumar. Review on hepatitis B virus precore/core promoter mutations and their correlation with genotypes and liver disease severityWorld Journal of Hepatology 2022; 14(4): 708-718 doi: 10.4254/wjh.v14.i4.708
40
Lorenzo Piermatteo, Mohammad Alkhatib, Stefano D’Anna, Vincenzo Malagnino, Ada Bertoli, Eleonora Andreassi, Elisa Basile, Alessandra Iuvara, Maria De Cristofaro, Giuseppina Cappiello, Carlotta Cerva, Carmine Minichini, Mariantonietta Pisaturo, Mario Starace, Nicola Coppola, Carla Fontana, Sandro Grelli, Francesca Ceccherini-Silberstein, Massimo Andreoni, Upkar S. Gill, Patrick T. F. Kennedy, Loredana Sarmati, Romina Salpini, Valentina Svicher. HBeAg Levels Vary across the Different Stages of HBV Infection According to the Extent of Immunological Pressure and Are Associated with Therapeutic Outcome in the Setting of Immunosuppression-Driven HBV ReactivationBiomedicines 2021; 9(10): 1352 doi: 10.3390/biomedicines9101352
41
Atsuya Yamashita, Hirotake Kasai, Shinya Maekawa, Tomohisa Tanaka, Yasunori Akaike, Akihide Ryo, Nobuyuki Enomoto, Kohji Moriishi. Berberine promotes K48-linked polyubiquitination of HNF4α, leading to the inhibition of HBV replicationAntiviral Research 2024; 232: 106027 doi: 10.1016/j.antiviral.2024.106027
42
Forough Golsaz-Shirazi, Fazel Shokri. Hepatitis B Immunopathogenesis and ImmunotherapyImmunotherapy 2016; 8(4): 461 doi: 10.2217/imt.16.3
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R Chauhan, N D Churchill, P M Mulrooney-Cousins, T I Michalak. Initial sites of hepadnavirus integration into host genome in human hepatocytes and in the woodchuck model of hepatitis B-associated hepatocellular carcinomaOncogenesis 2017; 6(4): e317 doi: 10.1038/oncsis.2017.22
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Hong Zang, Zhihui Xu, Yan Liu, Xiaodong Li, Yihui Rong, Ling Jiang, Shaoli You, Jinhua Hu, Jun Zhao, Dongping Xu, Shaojie Xin. Clinical and virological implications of A1846T and C1913A/G mutations of hepatitis B virus genome in severe liver diseasesScandinavian Journal of Gastroenterology 2018; 53(3): 319 doi: 10.1080/00365521.2018.1424934
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Kristi L. Turton, Vanessa Meier-Stephenson, Maulik D. Badmalia, Carla S. Coffin, Trushar R. Patel. Host Transcription Factors in Hepatitis B Virus RNA SynthesisViruses 2020; 12(2): 160 doi: 10.3390/v12020160
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María Mercedes Elizalde, Laura Mojsiejczuk, Micaela Speroni, Belén Bouzas, Luciana Tadey, Lilia Mammana, Rodolfo Héctor Campos, Diego Martín Flichman. Molecular and biological characterization of hepatitis B virus subgenotype F1b clusters: Unraveling its role in hepatocarcinogenesisFrontiers in Microbiology 2022; 13 doi: 10.3389/fmicb.2022.946703
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Xue-Yan Wang, Tim J. Harrison, Qin-Yan Chen, Hai Li, Guo-Jian Li, Mo-Han Liu, Li-Ping Hu, Chao Tan, Qing-Li Yang, Zhong-Liao Fang. The incidence rate over 10years of naturally occurring, cancer related mutations in the basal core promoter of hepatitis B virusInfection, Genetics and Evolution 2015; 34: 75 doi: 10.1016/j.meegid.2015.07.020
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Selene García-García, Andrea Caballero-Garralda, David Tabernero, Maria Francesca Cortese, Josep Gregori, Francisco Rodriguez-Algarra, Josep Quer, Mar Riveiro-Barciela, Maria Homs, Ariadna Rando-Segura, Beatriz Pacin-Ruiz, Marta Vila, Roser Ferrer-Costa, Tomas Pumarola, Maria Buti, Francisco Rodriguez-Frias. Hepatitis B Virus Variants with Multiple Insertions and/or Deletions in the X Open Reading Frame 3′ End: Common Members of Viral Quasispecies in Chronic Hepatitis B PatientsBiomedicines 2022; 10(5): 1194 doi: 10.3390/biomedicines10051194
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María Mercedes Elizalde, Luciana Tadey, Lilia Mammana, Jorge Fabián Quarleri, Rodolfo Héctor Campos, Diego Martín Flichman. Biological Characterization of Hepatitis B virus Genotypes: Their Role in Viral Replication and Antigen ExpressionFrontiers in Microbiology 2021; 12 doi: 10.3389/fmicb.2021.758613
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Yaqin Peng, Yutang Li, Jinlin Hou, Jian Sun, Mingze Su, Yao Li, Kuanhui Xiang, Ling Yan, Hui Zhuang, Tong Li. The nucleotide changes within HBV core promoter/precore during the first 12weeks of nucleos(t)ide treatment might be associated with a better virological responseInfection, Genetics and Evolution 2017; 49: 116 doi: 10.1016/j.meegid.2017.01.009
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Tsutomu Nishizawa, Takashi Hoshino, Atsushi Naganuma, Tominari Kobayashi, Shigeo Nagashima, Masaharu Takahashi, Hitoshi Takagi, Hiroaki Okamoto. Enhanced pregenomic RNA levels and lowered precore mRNA transcription efficiency in a genotype A hepatitis B virus genome with C1766T and T1768A mutations obtained from a fulminant hepatitis patientJournal of General Virology 2016; 97(10): 2643 doi: 10.1099/jgv.0.000566
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Shu Shi, Mingchen Liu, Jingyuan Xi, Hui Liu, Guiwen Guan, Congle Shen, Zhengyang Guo, Ting Zhang, Qiang Xu, Dilidaer Kudereti, Xiangmei Chen, Jie Wang, Fengmin Lu. Sex-determining region Y box 4 (SOX4) suppresses Hepatitis B virus replication by inhibiting hepatocyte nuclear factor 4α expressionAntiviral Research 2020; 176: 104745 doi: 10.1016/j.antiviral.2020.104745
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Prakriti Sinha, Chloe L. Thio, Ashwin Balagopal. Intracellular Host Restriction of Hepatitis B Virus ReplicationViruses 2024; 16(5): 764 doi: 10.3390/v16050764
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Xiao-Ling Wang, Jian-Ping Ren, Xue-Qing Wang, Xiao-Hong Wang, Shao-Fang Yang, Yi Xiong. Mutations in pre-core and basic core promoter regions of hepatitis B virus in chronic hepatitis B patientsWorld Journal of Gastroenterology 2016; 22(11): 3268-3274 doi: 10.3748/wjg.v22.i11.3268
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Yongxuan Yao, Bo Yang, Huang Cao, Kaitao Zhao, Yifei Yuan, Yingshan Chen, Zhenhua Zhang, Yun Wang, Rongjuan Pei, Jizheng Chen, Xue Hu, Yuan Zhou, Mengji Lu, Chunchen Wu, Xinwen Chen. RBM24 stabilizes hepatitis B virus pregenomic RNA but inhibits core protein translation by targeting the terminal redundancy sequenceEmerging Microbes & Infections 2018; 7(1): 1 doi: 10.1038/s41426-018-0091-4
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Marwa K. Ibrahim, Tawfeek H. Abdelhafez, Junko S. Takeuchi, Kosho Wakae, Masaya Sugiyama, Masataka Tsuge, Masahiko Ito, Koichi Watashi, Mohamed El Kassas, Takanobu Kato, Asako Murayama, Tetsuro Suzuki, Kazuaki Chayama, Kunitada Shimotohno, Masamichi Muramatsu, Hussein H. Aly, Takaji Wakita, J.-H. James Ou. MafF Is an Antiviral Host Factor That Suppresses Transcription from Hepatitis B Virus Core PromoterJournal of Virology 2021; 95(15) doi: 10.1128/JVI.00767-21
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Suchandrima Ghosh, Anannya Chakraborty, Soma Banerjee. Persistence of Hepatitis B Virus Infection: A Multi-Faceted Player for HepatocarcinogenesisFrontiers in Microbiology 2021; 12 doi: 10.3389/fmicb.2021.678537
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Dina Kremsdorf, Bouchra Lekbaby, Pierre Bablon, Jules Sotty, Jérémy Augustin, Aurélie Schnuriger, Jonathan Pol, Patrick Soussan. Alternative splicing of viral transcripts: the dark side of HBVGut 2021; 70(12): 2373 doi: 10.1136/gutjnl-2021-324554
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Farooq Rashid, Zhixun Xie, You Wei, Zhiqin Xie, Liji Xie, Meng Li, Sisi Luo. Biological features of fowl adenovirus serotype-4Frontiers in Cellular and Infection Microbiology 2024; 14 doi: 10.3389/fcimb.2024.1370414
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María Mercedes Elizalde, Micaela Speroni, Rodolfo Héctor Campos, Diego Martín Flichman. Hepatitis B Virus X Gene Differentially Modulates Subgenotype F1b and F4 ReplicationViruses 2019; 11(7): 655 doi: 10.3390/v11070655
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George Sebastian Gherlan. Occult hepatitis B — the result of the host immune response interaction with different genomic expressions of the virusWorld Journal of Clinical Cases 2022; 10(17): 5518-5530 doi: 10.12998/wjcc.v10.i17.5518
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Sergio Hernández, Francisca Álvarez-Astudillo, Daniel Garrido, Cristian Prieto, Alejandra Loyola, Rodrigo A. Villanueva. Canonical and Divergent N-Terminal HBx Isoform Proteins Unveiled: Characteristics and Roles during HBV ReplicationBiomedicines 2021; 9(11): 1701 doi: 10.3390/biomedicines9111701