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For: Li T, Leong MH, Harms B, Kennedy G, Chen L. MicroRNA-21 as a potential colon and rectal cancer biomarker. World J Gastroenterol 2013; 19(34): 5615-5621 [PMID: 24039353 DOI: 10.3748/wjg.v19.i34.5615]
URL: https://www.wjgnet.com/1007-9327/full/v19/i34/5615.htm
Number Citing Articles
1
Yin-Hung Chu, Ming-Ju Hsieh, Hui-Ling Chiou, Yi-Sheng Liou, Chen-Chieh Yang, Shun-Fa Yang, Wu-Hsien Kuo, Valli De Re. MicroRNA Gene Polymorphisms and Environmental Factors Increase Patient Susceptibility to Hepatocellular Carcinoma. PLoS ONE 2014; 9(2) doi: 10.1371/journal.pone.0089930
2
Eva Hofsli, Pål Sætrom, Eivind Ness-Jensen, Helja-Marja Surcel, Robin Mjelle. Can circulating microRNAs predict colorectal cancer? Results from a nested case–control study of pre-diagnostic serum samples from two prospective biobanks. BMC Cancer 2025; 25(1) doi: 10.1186/s12885-025-13854-1
3
Shichao Li, Xiaorong Yang, Jinmei Yang, Jiesheng Zhen, Dechun Zhang. Serum microRNA-21 as a potential diagnostic biomarker for breast cancer: a systematic review and meta-analysis. Clinical and Experimental Medicine 2016; 16(1) doi: 10.1007/s10238-014-0332-3
4
Lu Si, Fei Jiang, Yuan Li, Xianqing Ye, Juan Mu, Xingxing Wang, Shilong Ning, Chunyan Hu, Zhong Li. Induction of the mesenchymal to epithelial transition by demethylation‐ activated microRNA‐200c is involved in the anti‐migration/invasion effects of arsenic trioxide on human breast cancer cells. Molecular Carcinogenesis 2015; 54(9) doi: 10.1002/mc.22157
5
SHANSHAN JIANG, RENSHENG CHEN, JIANAN YU, NIANSHUANG LI, RONG KE, LINGYU LUO, JUNRONG ZOU, JIANGNAN ZHANG, KUNHE ZHANG, NONGHUA LU, DEQIANG HUANG. Clinical significance and role of LKB1 in gastric cancer. Molecular Medicine Reports 2016; 13(1) doi: 10.3892/mmr.2015.4508
6
Anne Haahr Mellergaard Eriksen, Rikke Fredslund Andersen, Boye Schnack Nielsen, Flemming Brandt Sørensen, Ane Lindegaard Appelt, Anders Jakobsen, Torben Frøstrup Hansen, Rajvir Dahiya. Intratumoral Heterogeneity of MicroRNA Expression in Rectal Cancer. PLOS ONE 2016; 11(6) doi: 10.1371/journal.pone.0156919
7
Ayaka Sato, Yasuko Fujita, Koki Otsuka, Akira Sasaki, Hiromu Suzuki, Takayuki Matsumoto, Tamotsu Sugai. Differential expression of microRNAs in colorectal cancer: Different patterns between isolated cancer gland and stromal cells. Pathology International 2020; 70(1) doi: 10.1111/pin.12872
8
Chunmei Yang, Wenzhu Lu, Hongbo He, Hong Liu. Inflammation and DNA Methylation–Dependent Down-Regulation of miR-34b-5p Mediates c-MYC Expression and CRL4DCAF4 E3 Ligase Activity in Colitis-Associated Cancer. The American Journal of Pathology 2020; 190(3) doi: 10.1016/j.ajpath.2019.11.013
9
Cheng Yan, Changsong Ding, Guihua Duan. PMMS: Predicting essential miRNAs based on multi-head self-attention mechanism and sequences. Frontiers in Medicine 2022; 9 doi: 10.3389/fmed.2022.1015278
10
Wei Liu, Li Xu, Yanjun Lyu, Chuanxu Yang. MXene-integrated CRISPR/Cas12a biosensor with Split activators for direct and rapid fluorescent detection of MicroRNA. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 2026; 346 doi: 10.1016/j.saa.2025.126850
11
Michiko Narita, Eri Shimura, Atsumi Nagasawa, Toshiki Aiuchi, Yukari Suda, Yusuke Hamada, Daigo Ikegami, Chizuru Iwasawa, Kazuhiko Arakawa, Katsuhide Igarashi, Naoko Kuzumaki, Yusuke Yoshioka, Takahiro Ochiya, Hideyuki Takeshima, Toshikazu Ushijima, Minoru Narita, Karl X Chai. Chronic treatment of non-small-cell lung cancer cells with gefitinib leads to an epigenetic loss of epithelial properties associated with reductions in microRNA-155 and -200c. PLOS ONE 2017; 12(2) doi: 10.1371/journal.pone.0172115
12
K. L. Markova, M. S. Zementova, E. S. Vashukova, M. A. Pereviazkina, S. A. Selkov, D. I. Sokolov. MicroRNA of extracellular vesicles as biomarkers and regulators of pathological and physiological processes. Medical Immunology (Russia) 2023; 26(1) doi: 10.15789/1563-0625-MOE-2617
13
Lui Ng, Ryan Wai‐Yan Sin, David Him Cheung, Carlos King‐Ho Wong, Cindy Lo‐Kuen Lam, Wai‐Keung Leung, Wai‐Lun Law, Dominic Chi‐Chung Foo. Identification and evaluation of a serum microRNA panel to diagnose colorectal cancer patients. International Journal of Cancer 2025; 156(4) doi: 10.1002/ijc.35175
14
E. S. Vashukova, A. S. Glotov, V. S. Baranov. MicroRNAs Associated with Preeclampsia. Russian Journal of Genetics 2020; 56(1) doi: 10.1134/S1022795419080167
15
Bin Li, Peng Chen, Yanxiang Chang, Jingpeng Qi, Hui Fu, Huifang Guo. Let-7a inhibits tumor cell growth and metastasis by directly targeting RTKN in human colon cancer. Biochemical and Biophysical Research Communications 2016; 478(2) doi: 10.1016/j.bbrc.2016.08.018
16
Archana Joon, Rekha Jalandra. microRNA Modulation: A Promising Combination Therapy for Cancer. 2026;  doi: 10.1007/978-981-95-5989-3_5
17
BIJING MAO, HE XIAO, ZHIMIN ZHANG, DONG WANG, GE WANG. MicroRNA-21 regulates the expression of BTG2 in HepG2 liver cancer cells. Molecular Medicine Reports 2015; 12(4) doi: 10.3892/mmr.2015.4051
18
Yanpeng Xing, Hongyu Jing, Ye Zhang, Jian Suo, Ming Qian. MicroRNA-141-3p affected proliferation, chemosensitivity, migration and invasion of colorectal cancer cells by targeting EGFR. The International Journal of Biochemistry & Cell Biology 2020; 118 doi: 10.1016/j.biocel.2019.105643
19
Sidra Amin, Klaudia Marcinkowska, Magdalena Wołoszyńska, Sebastian Opaliński, Dawid Skrzypczak, Paweł Wiercik, Łukasz Bobak, Agnieszka Śmieszek. Evaluation of the Cytotoxicity of Biochar Aqueous Extract in Caco-2 Cells: Time-Dependent Regulation of Apoptosis, Associated with miRNA Modulation. Molecules 2026; 31(6) doi: 10.3390/molecules31060989
20
Yun-Jie Hao, Chih-Yung Yang, Ming-Hsien Chen, Lu-Wey Chang, Chien-Ping Lin, Liang-Chuan Lo, Sheng-Chieh Huang, You-You Lyu, Jeng-Kai Jiang, Fan-Gang Tseng. Potential Values of Circulating microRNA-21 to Predict Early Recurrence in Patients with Colorectal Cancer after Treatments. Journal of Clinical Medicine 2022; 11(9) doi: 10.3390/jcm11092400
21
Chun Gao, Jing-Tao Li, Long Fang, Ying-Ying Xu, Hong-Chuan Zhao, Konradin Metze. Drug Allergy and the Risk of Lymph Node Metastasis in Rectal Cancer. PLoS ONE 2014; 9(8) doi: 10.1371/journal.pone.0106123
22
Chen Li, Na Xu, Yu-Qiang Li, Yu Wang, Zhi-Tu Zhu. Inhibition of SW620 human colon cancer cells by upregulating miRNA-145. World Journal of Gastroenterology 2016; 22(9): 2771-2778 doi: 10.3748/wjg.v22.i9.2771
23
Xingwang Yang, Xiaoming Wang, Hongyan Shen, Rong Deng, Kecheng Xue. Combination of miR-21 with Circulating Tumor Cells Markers Improve Diagnostic Specificity of Metastatic Breast Cancer. Cell Biochemistry and Biophysics 2015; 73(1) doi: 10.1007/s12013-015-0573-0
24
Lui Ng, Timothy Ming-Hun Wan, Johnny Hon-Wai Man, Ariel Ka-Man Chow, Deepak Iyer, Guanghua Chen, Thomas Chung-Cheung Yau, Oswens Siu-Hung Lo, Dominic Chi-Chung Foo, Jensen Tung-Chung Poon, Wai-Keung Leung, Roberta Wen-Chi Pang, Wai-Lun Law. Identification of serum miR-139-3p as a non-invasive biomarker for colorectal cancer. Oncotarget 2017; 8(16) doi: 10.18632/oncotarget.16171
25
Chao Lv, Wen-Xian Yu, Yan Wang, Da-Jing Yi, Ming-Hua Zeng, Hong-Mei Xiao. MiR-21 in extracellular vesicles contributes to the growth of fertilized eggs and embryo development in mice. Bioscience Reports 2018; 38(4) doi: 10.1042/BSR20180036
26
Farahnaz Moghadamnia, Pegah Ghoraeian, Sara Minaeian, Atefeh Talebi, Farnaz Farsi, Abolfazl Akbari. MicroRNA Expression and Correlation with mRNA Levels of Colorectal Cancer-Related Genes. Journal of Gastrointestinal Cancer 2020; 51(1) doi: 10.1007/s12029-019-00249-2
27
Jan Kral, Vlasta Korenkova, Vendula Novosadova, Lucie Langerova, Michaela Schneiderova, Vaclav Liska, Miroslav Levy, Veronika Veskrnova, Julius Spicak, Alena Opattova, Katerina Jiraskova, Veronika Vymetalkova, Pavel Vodicka, Jana Slyskova. Expression profile of miR-17/92 cluster is predictive of treatment response in rectal cancer. Carcinogenesis 2018; 39(11) doi: 10.1093/carcin/bgy100
28
Hao Zhou, Hongyan Liu, Miao Jiang, Shaoren Zhang, Junfeng Chen, Xiaoming Fan. Targeting MicroRNA-21 Suppresses Gastric Cancer Cell Proliferation and Migration via PTEN/Akt Signaling Axis. Cell Transplantation 2019; 28(3) doi: 10.1177/0963689719825573
29
Hélder Almeida-Lousada, André Mestre, Sara Ramalhete, Aryeh J. Price, Ramon Andrade de Mello, Ana D. Marreiros, Ricardo Pires das Neves, Pedro Castelo-Branco. Screening for Colorectal Cancer Leading into a New Decade: The “Roaring ‘20s” for Epigenetic Biomarkers?. Current Oncology 2021; 28(6) doi: 10.3390/curroncol28060411
30
Chao Zhang, Ya-Ran Shi, Xiao-Ran Liu, Yong-Chun Cao, Di Zhen, Zi-Ye Jia, Jin-Qi Jiang, Jian-Hui Tian, Jian-Ming Gao, Xiuchun (Cindy) Tian. The Anti-Apoptotic Role of Berberine in Preimplantation Embryo In Vitro Development through Regulation of miRNA-21. PLOS ONE 2015; 10(6) doi: 10.1371/journal.pone.0129527
31
Seungbin Cha, Eun-Hye Seo, Seung Lee, Kyung Kim, Chung-Sik Oh, Jong-Seok Moon, Jin Kim. MicroRNA Expression in Extracellular Vesicles from Nasal Lavage Fluid in Chronic Rhinosinusitis. Biomedicines 2021; 9(5) doi: 10.3390/biomedicines9050471
32
Geping Wu, Guanghai Yang, Ruxin Zhang, Guangyin Xu, Ling Zhang, Wu Wen, Jianbing Lu, Jianyong Liu, Yan Yu. Altered microRNA Expression Profiles of Extracellular Vesicles in Nasal Mucus From Patients With Allergic Rhinitis. Allergy, Asthma & Immunology Research 2015; 7(5) doi: 10.4168/aair.2015.7.5.449
33
Guosong Li, Yanjun Yang, Siliang Xu, Mingtang He, Ziqing Zhang. mir-21-5p inhibits the progression of human chondrosarcoma by regulating CCR7/STAT3/NF-κB pathway. Connective Tissue Research 2021; 62(3) doi: 10.1080/03008207.2019.1702650
34
Tejaswi Mudadla, Gayatri Sharma, Apoorva Mishra, Shefali Gola. Multifaceted Landscape of Omics Data. Bio-Algorithms and Med-Systems 2024; 20(1) doi: 10.5604/01.3001.0054.8093
35
Mohammad Alam Jafri, Syed Kashif Zaidi, Shakeel Ahmed Ansari, Mohammed Hussein Al-Qahtani, Jerry W Shay. MicroRNAs as potential drug targets for therapeutic intervention in colorectal cancer. Expert Opinion on Therapeutic Targets 2015; 19(12) doi: 10.1517/14728222.2015.1069816
36
ZUOLIANG DONG, LI REN, LI LIN, JIANG LI, YIWEN HUANG, JINHONG LI. Effect of microRNA-21 on multidrug resistance reversal in A549/DDP human lung cancer cells. Molecular Medicine Reports 2015; 11(1) doi: 10.3892/mmr.2014.2662
37
R Nedaeinia, M Manian, M H Jazayeri, M Ranjbar, R Salehi, M Sharifi, F Mohaghegh, M Goli, S H Jahednia, A Avan, M Ghayour-Mobarhan. Circulating exosomes and exosomal microRNAs as biomarkers in gastrointestinal cancer. Cancer Gene Therapy 2017; 24(2) doi: 10.1038/cgt.2016.77
38
Ling-Li Huang, Ling-Wei Huang, Lei Wang, Ben-Ding Tong, Qing Wei, Xuan-Sheng Ding. Potential role of miR-139-5p in cancer diagnosis, prognosis and therapy. Oncology Letters 2017; 14(2) doi: 10.3892/ol.2017.6351
39
F. Xu, L. Xu, M. Wang, G. An, G. Feng. The accuracy of circulating microRNA‐21 in the diagnosis of colorectal cancer: a systematic review and meta‐analysis. Colorectal Disease 2015; 17(5) doi: 10.1111/codi.12917
40
Xiangkun Zhao, Yuteng Yang, Yaqi Wang, Xi Chen, Yisong Yao, Ting Yuan, Jiaxuan Li, Yumei Li, Xicheng Song. Roles of noncoding RNA in allergic rhinitis. International Forum of Allergy & Rhinology 2024; 14(11) doi: 10.1002/alr.23461
41
miR-96 and its versatile role in cancer. Advances in Cancer Biology - Metastasis 2023; 7 doi: 10.1016/j.adcanc.2022.100082
42
Anne Haahr Mellergaard Eriksen, Flemming Brandt Sørensen, Rikke Fredslund Andersen, Anders Jakobsen, Torben Frøstrup Hansen. Association between the expression of microRNAs and the response of patients with locally advanced rectal cancer to preoperative chemoradiotherapy. Oncology Letters 2017; 14(1) doi: 10.3892/ol.2017.6141
43
Xin-Hao Zhang, Ya-Na Zhang, Zheng Liu. MicroRNA in Chronic Rhinosinusitis and Allergic Rhinitis. Current Allergy and Asthma Reports 2014; 14(2) doi: 10.1007/s11882-013-0415-3
44
Paula Mussnich, Roberta Rosa, Roberto Bianco, Alfredo Fusco, Daniela D’Angelo. MiR-199a-5p and miR-375 affect colon cancer cell sensitivity to cetuximab by targeting PHLPP1. Expert Opinion on Therapeutic Targets 2015; 19(8) doi: 10.1517/14728222.2015.1057569
45
Zheng Liu, Xin-Hao Zhang, Borja Callejas-Díaz, Joaquim Mullol. MicroRNA in United Airway Diseases. International Journal of Molecular Sciences 2016; 17(5) doi: 10.3390/ijms17050716
46
Chao Zhang, Ya-Ran Shi, Xiao-Ran Liu, Yong-Chun Cao, Jin-Ling Tian, Zi-Ye Jia, Di Zhen, Feng-Hua Liu, Jian-Ming Gao. The regulatory role of icariin on apoptosis in mouse preimplantation embryos with reduced microRNA-21. Theriogenology 2014; 82(3) doi: 10.1016/j.theriogenology.2014.05.006
47
Yi-Jing Tao, Yong-ju Li, Wen Zheng, Juan-juan Zhao, Meng-meng Guo, Ya Zhou, Na-lin Qin, Jing Zheng, Lin Xu. Antisense oligonucleotides against microRNA-21 reduced the proliferation and migration of human colon carcinoma cells. Cancer Cell International 2015; 15(1) doi: 10.1186/s12935-015-0228-7
48
Guoqiao Huang, Jing Zhang, Yinghao Cheng, Chan Li, Qiufeng Song, Chang Xue, Zai-sheng Wu, Zhifa Shen. Target-induced multiple palindrome-mediated strand displacement amplification of Scarecrow-shaped DNA nanoprobe for ultrasensitive detection of MicroRNA. Sensors and Actuators B: Chemical 2023; 376 doi: 10.1016/j.snb.2022.133003
49
Wenjing Zhou, Gang Xu, Yunqiu Wang, Ziao Xu, Xiaofei Liu, Xia Xu, Guijie Ren, Keli Tian. Oxidative stress induced autophagy in cancer associated fibroblast enhances proliferation and metabolism of colorectal cancer cells. Cell Cycle 2017; 16(1) doi: 10.1080/15384101.2016.1252882
50
Wenxian Zhang, Guangchun Xiao, Jun Chen, Li Wang, Qiongzheng Hu, Jian Wu, Wenhong Zhang, Ming Song, Jinwei Qiao, Chonghai Xu. Electrochemical biosensors for measurement of colorectal cancer biomarkers. Analytical and Bioanalytical Chemistry 2021; 413(9) doi: 10.1007/s00216-021-03197-8
51
Yinxue Yang, Yong Du, Xiaoming Liu, William C. Cho. Non-coding RNAs in Colorectal Cancer. Advances in Experimental Medicine and Biology 2016; 937 doi: 10.1007/978-3-319-42059-2_2
52
Jong Min Lim, Myung Yi Ryu, Jong Won Yun, Tae Jung Park, Jong Pil Park. Electrochemical peptide sensor for diagnosing adenoma-carcinoma transition in colon cancer. Biosensors and Bioelectronics 2017; 98 doi: 10.1016/j.bios.2017.07.013
53
Giuseppe S. Sica, Cristina Fiorani, Carmine Stolfi, Giovanni Monteleone, Eleonora Candi, Ivano Amelio, Valeria Catani, Simone Sibio, Andrea Divizia, Giorgia Tema, Edoardo Iaculli, Achille L. Gaspari. Peritoneal expression of matrilysin helps identify early post-operative recurrence of colorectal cancer. Oncotarget 2015; 6(15) doi: 10.18632/oncotarget.2830
54
Wenying Yan, Lihua Xu, Zhandong Sun, Yuxin Lin, Wenyu Zhang, Jiajia Chen, Shaoyan Hu, Bairong Shen. MicroRNA biomarker identification for pediatric acute myeloid leukemia based on a novel bioinformatics model. Oncotarget 2015; 6(28) doi: 10.18632/oncotarget.4459
55
Simon R. Whiteoak, Richard Felwick, Tilman Sanchez-Elsner, J. R. Fraser Cummings. MicroRNAs in Inflammatory Bowel Diseases. Inflammatory Bowel Diseases 2015; 21(5) doi: 10.1097/MIB.0000000000000288
56
Huachuan Zhang, Mengqi Xiang, Jing Chen, Fazhi Zhao. DRNP-G4: a CRISPR-based dual-mode biosensor for amplification-free and ultrasensitive detection of miRNA-21. Microchemical Journal 2026; 220 doi: 10.1016/j.microc.2025.116623
57
Shanthi Sabarimurugan, Madurantakam Royam Madhav, Chellan Kumarasamy, Ajay Gupta, Siddharta Baxi, Sunil Krishnan, Rama Jayaraj. Prognostic Value of MicroRNAs in Stage II Colorectal Cancer Patients: A Systematic Review and Meta-Analysis. Molecular Diagnosis & Therapy 2020; 24(1) doi: 10.1007/s40291-019-00440-y
58
Cory Pettit, Steve Walston, Patrick Wald, Amy Webb, Terence M. Williams. Molecular profiling of locally-advanced rectal adenocarcinoma using microRNA expression (Review). International Journal of Oncology 2017; 51(2) doi: 10.3892/ijo.2017.4045
59
Siwei Chen, Chong Lu, Shengjie Lin, Chen Sun, Zhenyu Wen, Zhenjian Ge, Wenkang Chen, Yingqi Li, Pengwu Zhang, Yutong Wu, Wuping Wang, Huimei Zhou, Xutai Li, Yongqing Lai, Hang Li. A panel based on three-miRNAs as diagnostic biomarker for prostate cancer. Frontiers in Genetics 2024; 15 doi: 10.3389/fgene.2024.1371441
60
Noha G. Bader El Din, Marwa K. Ibrahim, Reem El‐Shenawy, Ghada M. Salum, Sally Farouk, Naglaa Zayed, Ahmed Khairy, Mostafa El Awady. MicroRNAs expression profiling in Egyptian colorectal cancer patients. IUBMB Life 2020; 72(2) doi: 10.1002/iub.2164
61
Chae Hwan Cho, Ji Hong Kim, Jayoung Kim, Jong Won Yun, Tae Jung Park, Jong Pil Park. Re-engineering of peptides with high binding affinity to develop an advanced electrochemical sensor for colon cancer diagnosis. Analytica Chimica Acta 2021; 1146 doi: 10.1016/j.aca.2020.11.011
62
Reza Nedaeinia, Amir Avan, Mehdi Ahmadian, Sasan Nedaee Nia, Maryam Ranjbar, Mohammadreza Sharifi, Mohammad Goli, Ahmad Piroozmand, Esmail Nourmohammadi, Mostafa Manian, Gordon A. Ferns, Majid Ghayour‐Mobarhan, Rasoul Salehi. Current Status and Perspectives Regarding LNA‐Anti‐miR Oligonucleotides and microRNA miR‐21 Inhibitors as a Potential Therapeutic Option in Treatment of Colorectal Cancer. Journal of Cellular Biochemistry 2017; 118(12) doi: 10.1002/jcb.26047
63
Yin Lam Chu, Harriet Li, Pik Lan Amanda Ng, Siu Ting Kong, Hao Zhang, Yusheng Lin, William Chi Shing Tai, Allen Chi Shing Yu, Aldrin Kay Yuen Yim, Hin Fung Tsang, William Chi Shing Cho, Sze Chuen Cesar Wong. The potential of circulating exosomal RNA biomarkers in cancer. Expert Review of Molecular Diagnostics 2020; 20(7) doi: 10.1080/14737159.2020.1745064