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For: Romano C, Comito D, Famiani A, Calamarà S, Loddo I. Partially hydrolyzed guar gum in pediatric functional abdominal pain. World J Gastroenterol 2013; 19(2): 235-240 [PMID: 23345946 DOI: 10.3748/wjg.v19.i2.235]
URL: https://www.wjgnet.com/1007-9327/full/v19/i2/235.htm
Number Citing Articles
1
Samuel Nurko, Marc A. Benninga, Toni Solari, Bruno P. Chumpitazi. Pediatric Aspects of Nutrition Interventions for Disorders of Gut-Brain Interaction. American Journal of Gastroenterology 2022; 117(6) doi: 10.14309/ajg.0000000000001779
2
Rebecca A. Abbott, Alice E. Martin, Tamsin V. Newlove‐Delgado, Alison Bethel, Rebecca S. Whear, Jo Thompson Coon, Stuart Logan. Recurrent Abdominal Pain in Children. Journal of Pediatric Gastroenterology and Nutrition 2018; 67(1) doi: 10.1097/MPG.0000000000001922
3
Sujithra Velayuthan, Ben Freiberg, Diana Schnee, Maria Haught. Handbook of Clinical and Practical Pediatric Nutrition. 2025;  doi: 10.1007/978-3-031-97759-6_52
4
Theertham Pradyumna Rao, Giuseppina Quartarone. Role of guar fiber in improving digestive health and function. Nutrition 2019; 59 doi: 10.1016/j.nut.2018.07.109
5
Yuka Inaoka Yokogawa, Eri Oyanagi, Takafumi Aoki, Chihiro Watanabe, Suzuka Miura, Michael J. Kremenik, Hiromi Yano. LPS-induced TNF-α production is attenuated by intake with PHGG via gut microbial fermentation in mice. Nutrition 2022; 101 doi: 10.1016/j.nut.2022.111705
6
Siba Prosad Paul, Dharamveer Basude. Non-pharmacological management of abdominal pain-related functional gastrointestinal disorders in children. World Journal of Pediatrics 2016; 12(4) doi: 10.1007/s12519-016-0044-8
7
Claudio Romano, Socrate Pallio, Ugo Cucinotta, Paola Accorsi, Valeria Dipasquale. Fibers in pediatric functional gastrointestinal disorders. Practical considerations from clinical cases. Expert Review of Gastroenterology & Hepatology 2021; 15(6) doi: 10.1080/17474124.2021.1884543
8
Leanne K. Mitchell, Peter S. W. Davies. Pre- and probiotics in the management of children with autism and gut issues: a review of the current evidence. European Journal of Clinical Nutrition 2022; 76(7) doi: 10.1038/s41430-021-01027-9
9
Jennifer Andrews, Zachery Harkey, Sarah Mathena, Maureen Galindo, Sarrah Hannon, Rohith Jesudas, Christina M. Laukaitis, Martin E. Matsumura. Exploring cross-category relationships between symptoms in people with hypermobile EDS (hEDS) to identify disability patterns. PLOS One 2026; 21(9) doi: 10.1371/journal.pone.0357565
10
Can Hua, Yi-Lin Chen, Qing-Feng Tao, Yun-Zhou Shi, Li-Wen Li, Chao-Rong Xie, Min Chen, Zi-Li Zhou, Hui Zheng. Dietary interventions for pediatric patients with functional abdominal pain disorders: a systematic review and network meta-analysis. European Journal of Pediatrics 2023; 182(7) doi: 10.1007/s00431-023-04979-1
11
Dimitrios Polymeros, Iosif Beintaris, Asimina Gaglia, George Karamanolis, Ioannis S. Papanikolaou, George Dimitriadis, Konstantinos Triantafyllou. Partially Hydrolyzed Guar Gum Accelerates Colonic Transit Time and Improves Symptoms in Adults with Chronic Constipation. Digestive Diseases and Sciences 2014; 59(9) doi: 10.1007/s10620-014-3135-1
12
Bruno P. Chumpitazi. Update on Dietary Management of Childhood Functional Abdominal Pain Disorders. Gastroenterology Clinics of North America 2018; 47(4) doi: 10.1016/j.gtc.2018.07.001
13
Edward Thomas Andrews, R Mark Beattie, Mark P Tighe. Functional abdominal pain: what clinicians need to know. Archives of Disease in Childhood 2020; 105(10) doi: 10.1136/archdischild-2020-318825
14
Nicolaas Koen Vermeijden, Anna Oorthuys, Jip Groen, Nikhil Thapar, Arine Vlieger, Maria Giovanna Puoti, Osvaldo Borrelli, Marc Benninga. Current and novel therapeutic strategies in pediatric irritable bowel syndrome and functional abdominal pain-not otherwise specified. Expert Opinion on Pharmacotherapy 2025; 26(16) doi: 10.1080/14656566.2025.2582017
15
Juliette M.T.M. Rutten, Judith J. Korterink, Leonie M.A.J. Venmans, Marc A. Benninga, Merit M. Tabbers. Nonpharmacologic Treatment of Functional Abdominal Pain Disorders: A Systematic Review. Pediatrics 2015; 135(3) doi: 10.1542/peds.2014-2123
16
Leanne K. Mitchell, Helen S. Heussler, Christopher J. Burgess, Ateequr Rehman, Robert E. Steinert, Peter S.W. Davies. Gastrointestinal, Behaviour and Anxiety Outcomes in Autistic Children Following an Open Label, Randomised Pilot Study of Synbiotics vs Synbiotics and Gut-Directed Hypnotherapy. Journal of Autism and Developmental Disorders 2026; 56(3) doi: 10.1007/s10803-024-06588-9
17
Huiyu Chen, Jiale Ren, Langrun Wang, Wenyi Zhang, Sufang Duan, Jie Guo, Qingshan Chen, Ran Wang, Jian He, Jingjing He, Ruixin Zhu. Non-Digestible Oligosaccharides and Constipation: A Systematic Review and Meta-Analysis of Randomized Trials on Stool Frequency, Stool Consistency, and Fermentation Biomarkers. Nutrients 2025; 17(20) doi: 10.3390/nu17203246
18
Craig Friesen, Jennifer M Colombo, Amanda Deacy, Jennifer V Schurman. An Update on the Assessment and Management of Pediatric Abdominal Pain. Pediatric Health, Medicine and Therapeutics 2021;  doi: 10.2147/PHMT.S287719
19
Shaman Rajindrajith, Christopher Chiong-Meng Boey, Niranga Manjuri Devanarayana, Madunil Anuk Niriella, Nikhil Thapar, Marc Alexander Benninga. Navigating through 65 years of insights: lessons learned on functional abdominal pain in children. European Journal of Pediatrics 2024; 183(9) doi: 10.1007/s00431-024-05667-4
20
Use of Hydrocolloids to Control Food Appearance, Flavor, Texture, and Nutrition. 2023;  doi: 10.1002/9781119702139.ch9
21
Silvia Salvatore, Mariagrazia Carlino, Simona Sestito, Daniela Concolino, Massimo Agosti, Licia Pensabene. Nutraceuticals and Pain Disorders of the Gut–Brain Interaction in Infants and Children: A Narrative Review and Practical Insights. Nutrients 2024; 16(3) doi: 10.3390/nu16030349
22
Ashish Chogle, Stijn Mintjens, Miguel Saps. Pediatric IBS: An Overview on Pathophysiology, Diagnosis and Treatment. Pediatric Annals 2014; 43(4) doi: 10.3928/00904481-20140325-08
23
Simona Dragan, Maria-Corina Șerban, Georgiana Damian, Florina Buleu, Mihaela Valcovici, Ruxandra Christodorescu. Dietary Patterns and Interventions to Alleviate Chronic Pain. Nutrients 2020; 12(9) doi: 10.3390/nu12092510
24
Lara Tupper, Monique Terol, Jennifer Utter, Shannon Morley. The Role of Guar Fiber in Improving the Management of Irritable Bowel Syndrome, Functional Constipation, and Functional Diarrhea. Nutrition Today 2024; 59(1) doi: 10.1097/NT.0000000000000664
25
Andrea Brusaferro, Edoardo Farinelli, Letizia Zenzeri, Rita Cozzali, Susanna Esposito. The Management of Paediatric Functional Abdominal Pain Disorders: Latest Evidence. Pediatric Drugs 2018; 20(3) doi: 10.1007/s40272-018-0287-z
26
Maria Giovanna Puoti, Anna O. J. Oorthuys, Nicolaas Koen Vermeijden, Marc A. Benninga, Osvaldo Borrelli. Pharmacotherapy of Irritable Bowel Syndrome with Constipation in Children: An Update on Clinical Progress and Successes. Drugs 2026;  doi: 10.1007/s40265-026-02376-0
27
Judith Korterink, Niranga Manjuri Devanarayana, Shaman Rajindrajith, Arine Vlieger, Marc A. Benninga. Childhood functional abdominal pain: mechanisms and management. Nature Reviews Gastroenterology & Hepatology 2015; 12(3) doi: 10.1038/nrgastro.2015.21
28
Jip Groen, Morris Gordon, Ashish Chogle, Marc Benninga, Rachel Borlack, Osvaldo Borrelli, Anil Darbari, Jernej Dolinsek, Julie Khlevner, Carlo Di Lorenzo, Hannibal Person, Rinarani Sanghavi, Julie Snyder, Nikhil Thapar, Arine Vlieger, Vasiliki Sinopoulou, Merit Tabbers, Miguel Saps. ESPGHAN/NASPGHAN guidelines for treatment of irritable bowel syndrome and functional abdominal pain‐not otherwise specified in children aged 4–18 years. Journal of Pediatric Gastroenterology and Nutrition 2025; 81(2) doi: 10.1002/jpn3.70070
29
Mariana Del Carmen Fernández-Fígares Jiméne, Miguel López-Moreno. Ultra-processed Plant Foods: Are They Worse than their Unprocessed Animal-Based Counterparts?. Current Nutrition Reports 2025; 14(1) doi: 10.1007/s13668-025-00704-6
30
Cara Hannah Axelrod, Miguel Saps. The Role of Fiber in the Treatment of Functional Gastrointestinal Disorders in Children. Nutrients 2018; 10(11) doi: 10.3390/nu10111650
31
Li-Li Cai, Xuan Li, Qiu-Han Cai, Sheng-Xuan Guo, Yi Zhang, Wen-Cong Sun, Ze-Hui Zhao, Si-Yuan Hu. Irritable bowel syndrome in children: the placebo response rate and influencing factors a meta-analysis. Pediatric Research 2024; 95(6) doi: 10.1038/s41390-023-02996-2
32
Manu R. Sood, Katja Kovacic. Pediatric Neurogastroenterology. 2017;  doi: 10.1007/978-3-319-43268-7_38
33
Gabriel Olveira, Inmaculada González-Molero. An update on probiotics, prebiotics and symbiotics in clinical nutrition. Endocrinología y Nutrición (English Edition) 2016; 63(9) doi: 10.1016/j.endoen.2016.10.011
34
Judith Zeevenhooven, Merel L. Timp, Maartje M.J. Singendonk, Marc A. Benninga, Merit M. Tabbers. Definitions of Pediatric Functional Abdominal Pain Disorders and Outcome Measures: A Systematic Review. The Journal of Pediatrics 2019; 212 doi: 10.1016/j.jpeds.2019.04.048
35
Teresa Di Chio, Christiane Sokollik, Diego G. Peroni, Lara Hart, Giacomo Simonetti, Franziska Righini-Grunder, Osvaldo Borrelli. Nutritional Aspects of Pediatric Gastrointestinal Diseases. Nutrients 2021; 13(6) doi: 10.3390/nu13062109
36
Daniela Pop, Radu Samuel Pop, Dorin Farcău. The Use of Fibers, Herbal Medicines and Spices in Children with Irritable Bowel Syndrome: A Narrative Review. Nutrients 2023; 15(20) doi: 10.3390/nu15204351
37
Thomas Berger, Uta Rohr. Schmerztherapie bei Kindern, Jugendlichen und jungen Erwachsenen. 2015;  doi: 10.1007/978-3-662-45057-4_15
38
Partha Sarathi Chakraborty, Rhea Daniel, Fernando A. Navarro. Non-pharmacologic approaches to treatment of pediatric functional abdominal pain disorders. Frontiers in Pediatrics 2023; 11 doi: 10.3389/fped.2023.1118874
39
Silvia Salvatore, Maria Serena Battigaglia, Elena Murone, Eugenia Dozio, Licia Pensabene, Massimo Agosti. Dietary Fibers in Healthy Children and in Pediatric Gastrointestinal Disorders: A Practical Guide. Nutrients 2023; 15(9) doi: 10.3390/nu15092208
40
Robyn Rexwinkel, Arine M. Vlieger, Miguel Saps, Merit M. Tabbers, Marc A. Benninga. A therapeutic guide on pediatric irritable bowel syndrome and functional abdominal pain-not otherwise specified. European Journal of Pediatrics 2022; 181(7) doi: 10.1007/s00431-022-04459-y
41
Kathryn Hawa, Khalil Zaydan, Erik Andrewski. Pediatric Irritable Bowel Syndrome: Current Understanding and Future Directions. Current Treatment Options in Pediatrics 2025; 11(1) doi: 10.1007/s40746-025-00339-3
42
Jonathan C. Lebowitz, Lily Barash, Maria E. Perez. Irritable Bowel Syndrome: A Review of Management Strategies. Current Treatment Options in Pediatrics 2026; 12(1) doi: 10.1007/s40746-026-00366-8
43
Clara MA de Bruijn, Robyn Rexwinkel, Morris Gordon, Vassiliki Sinopoulou, Marc A Benninga, Merit M Tabbers. Dietary interventions for functional abdominal pain disorders in children: a systematic review and meta-analysis. Expert Review of Gastroenterology & Hepatology 2022; 16(4) doi: 10.1080/17474124.2022.2055547
44
Tomohisa Takagi, Yuji Naito, Yasuki Higashimura, Chihiro Ushiroda, Katsura Mizushima, Yuji Ohashi, Zenta Yasukawa, Makoto Ozeki, Makoto Tokunaga, Tsutomu Okubo, Kazuhiro Katada, Kazuhiro Kamada, Kazuhiko Uchiyama, Osamu Handa, Yoshito Itoh, Toshikazu Yoshikawa. Partially hydrolysed guar gum ameliorates murine intestinal inflammation in association with modulating luminal microbiota and SCFA. British Journal of Nutrition 2016; 116(7) doi: 10.1017/S0007114516003068
45
J. Bradley Morris, Ming Li Wang. Updated review of potential medicinal genetic resources in the USDA, ARS, PGRCU industrial and legume crop germplasm collections. Industrial Crops and Products 2018; 123 doi: 10.1016/j.indcrop.2018.07.014
46
Daniël R. Hoekman, Judith Zeevenhooven, Faridi S. van Etten-Jamaludin, Iuke Douwes Dekker, Marc A. Benninga, Merit M. Tabbers, Arine M. Vlieger. The Placebo Response in Pediatric Abdominal Pain-Related Functional Gastrointestinal Disorders: A Systematic Review and Meta-Analysis. The Journal of Pediatrics 2017; 182 doi: 10.1016/j.jpeds.2016.12.022
47
Bonnie J. Stevens, Gareth Hathway, William T. Zempsky, Jennifer Verrill Schurman, Amanda Drews Deacy, Craig A. Friesen. Oxford Textbook of Pediatric Pain. 2021;  doi: 10.1093/med/9780198818762.003.0030
48
Theertham Pradyumna Rao. Role of guar fiber in appetite control. Physiology & Behavior 2016; 164 doi: 10.1016/j.physbeh.2016.06.014
49
Eell Ryoo. Management of abdominal pain in pediatric emergency departments. Pediatric Emergency Medicine Journal 2018; 5(2) doi: 10.22470/pemj.2018.00311
50
Giovanni Di Nardo, Giovanni Barbara, Osvaldo Borrelli, Cesare Cremon, Valentina Giorgio, Luigi Greco, Michele La Pietra, Giovanni Marasco, Licia Pensabene, Marisa Piccirillo, Claudio Romano, Silvia Salvatore, Michele Saviano, Vincenzo Stanghellini, Caterina Strisciuglio, Renato Tambucci, Rossella Turco, Letizia Zenzeri, Annamaria Staiano. Italian guidelines for the management of irritable bowel syndrome in children and adolescents. Italian Journal of Pediatrics 2024; 50(1) doi: 10.1186/s13052-024-01607-y
51
Gabriel Olveira, Inmaculada González-Molero. Actualización de probióticos, prebióticos y simbióticos en nutrición clínica. Endocrinología y Nutrición 2016; 63(9) doi: 10.1016/j.endonu.2016.07.006
52
Gerard Minor, Timothy Sentongo, Ralf G. Heine, Boutaina Zemrani. Tolerability and safety of a semi-elemental enteral formula with partially hydrolyzed guar gum (PHGG) in tube-fed children aged 1–4 years: An open-label, single-arm study. Clinical Nutrition ESPEN 2023; 55 doi: 10.1016/j.clnesp.2023.04.004
53
Mahendra P. Kapoor, Masaaki Koido, Mikiko Kawaguchi, Derek Timm, Makoto Ozeki, Mari Yamada, Takayuki Mitsuya, Tsutomu Okubo. Lifestyle related changes with partially hydrolyzed guar gum dietary fiber in healthy athlete individuals – A randomized, double-blind, crossover, placebo-controlled gut microbiome clinical study. Journal of Functional Foods 2020; 72 doi: 10.1016/j.jff.2020.104067
54
Shun Takayama, Kazuhiro Katada, Tomohisa Takagi, Takaya Iida, Tomohiro Ueda, Katsura Mizushima, Yasuki Higashimura, Mayuko Morita, Tetsuya Okayama, Kazuhiro Kamada, Kazuhiko Uchiyama, Osamu Handa, Takeshi Ishikawa, Zenta Yasukawa, Tsutomu Okubo, Yoshito Itoh, Yuji Naito. Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis. World Journal of Gastroenterology 2021; 27(18): 2160-2176 doi: 10.3748/wjg.v27.i18.2160
55
Renee Korczak, Alison Kamil, Lisa Fleige, Sharon M. Donovan, Joanne L. Slavin. Dietary fiber and digestive health in children. Nutrition Reviews 2017; 75(4) doi: 10.1093/nutrit/nuw068
56
Takafumi Aoki, Eri Oyanagi, Chihiro Watanabe, Nanako Kobiki, Suzuka Miura, Yuka Yokogawa, Hiromi Kitamura, Fusako Teramoto, Michael J. Kremenik, Hiromi Yano. The Effect of Voluntary Exercise on Gut Microbiota in Partially Hydrolyzed Guar Gum Intake Mice under High-Fat Diet Feeding. Nutrients 2020; 12(9) doi: 10.3390/nu12092508
57
Natoshia R Cunningham, Jocelyn S Zuckerman, Manasi Kulkarni, Audrey Searles, Adrián Fernández-González, Elena R Serrano-Ibáñez, Iris Kovar-Gough, Rocío de la Vega. A scoping review of nonpharmacologic strategies for use with Mediterranean youth with mixed chronic pain conditions: a culturally adapted approach. Journal of Pediatric Psychology 2026;  doi: 10.1093/jpepsy/jsag064
58
Carrie A. M. Wegh, Margriet H. C. Schoterman, Elaine E. Vaughan, Clara Belzer, Marc A. Benninga. The effect of fiber and prebiotics on children’s gastrointestinal disorders and microbiome. Expert Review of Gastroenterology & Hepatology 2017; 11(11) doi: 10.1080/17474124.2017.1359539
59
Shaman Rajindrajith, Judith Zeevenhooven, Niranga Manjuri Devanarayana, Bonaventure Jayasiri Crispus Perera, Marc A. Benninga. Functional abdominal pain disorders in children. Expert Review of Gastroenterology & Hepatology 2018; 12(4) doi: 10.1080/17474124.2018.1438188
60
Tamsin V Newlove-Delgado, Alice E Martin, Rebecca A Abbott, Alison Bethel, Joanna Thompson-Coon, Rebecca Whear, Stuart Logan. Dietary interventions for recurrent abdominal pain in childhood. Cochrane Database of Systematic Reviews 2017; 2017(3) doi: 10.1002/14651858.CD010972.pub2
61
Chihiro Watanabe, Hinako Hirai, Takafumi Aoki, Hiromi Kataoka, Masanori Iseki, Hiroki Hamada, Masato Kawashima, Michael J. Kremenik, Hiromi Yano, Eri Oyanagi. Partially hydrolyzed guar gum intake alleviates lipopolysaccharide-induced systemic inflammation via gut microbial alteration in mice. Nutrition 2026; 142 doi: 10.1016/j.nut.2025.113009
62
Siba Prosad Paul, Penny Barnard, Charlotte Bigwood, David C. A. Candy. Challenges in management of irritable bowel syndrome in children. Indian Pediatrics 2013; 50(12) doi: 10.1007/s13312-013-0308-5