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For: Vajro P, Maddaluno S, Veropalumbo C. Persistent hypertransaminasemia in asymptomatic children: A stepwise approach. World J Gastroenterol 2013; 19(18): 2740-2751 [PMID: 23687411 DOI: 10.3748/wjg.v19.i18.2740]
URL: https://www.wjgnet.com/1007-9327/full/v19/i18/2740.htm
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Number Citing Articles
1
Markéta Veverková, Jakub Pecl, Tereza Pinkasová, Zdeňka Čermáková, Petr Jabandžiev. Macro-AST as a cause of isolated increase of aspartate aminotransferase in an asymptomatic patient. Pediatrie pro praxi 2021; 22(1) doi: 10.36290/ped.2021.010
2
Sagar Mehta, Tomisin John, Jordan J. Feld, Hemant Shah, Nisa Mullaithilaga, Aaron Campigotto, Karen Leung, Binita M. Kamath, Simon C. Ling, Michelle Science, Vicky L. Ng. Severe acute hepatitis of unknown etiology in a large cohort of children. Hepatology Communications 2023; 7(10) doi: 10.1097/HC9.0000000000000272
3
Marta Alonso‐Peña, Ricardo Espinosa‐Escudero, Elisa Herraez, Oscar Briz, Maria Luisa Cagigal, Jesus M. Gonzalez‐Santiago, Aida Ortega‐Alonso, Conrado Fernandez‐Rodriguez, Luis Bujanda, Marta Calvo Sanchez, Delia D´Avola, Maria‐Carlota Londoño, Moises Diago, Jose C. Fernandez‐Checa, Carmen Garcia‐Ruiz, Raul J. Andrade, Frank Lammert, Jesus Prieto, Javier Crespo, Javier Juamperez, Alvaro Diaz‐Gonzalez, Maria J. Monte, Jose J. G. Marin. Beneficial effect of ursodeoxycholic acid in patients with acyl‐CoA oxidase 2 (ACOX2) deficiency–associated hypertransaminasemia. Hepatology 2022; 76(5) doi: 10.1002/hep.32517
4
Jacopo Troisi, Federica Belmonte, Antonella Bisogno, Luca Pierri, Angelo Colucci, Giovanni Scala, Pierpaolo Cavallo, Claudia Mandato, Antonella Di Nuzzi, Laura Di Michele, Anna Pia Delli Bovi, Salvatore Guercio Nuzio, Pietro Vajro. Metabolomic Salivary Signature of Pediatric Obesity Related Liver Disease and Metabolic Syndrome. Nutrients 2019; 11(2) doi: 10.3390/nu11020274
5
Naouel Guirat Dhouib, Monia Ben Khaled, Monia Ouederni, Habib Besbes, Fethi Mellouli, Mohamed Bejaoui. Hypertransaminasemia revealing a clinically silent muscular dystrophy in a child with sickle cell disease. Annals of Hematology 2018; 97(11) doi: 10.1007/s00277-018-3360-3
6
Pietro Vajro. Transaminases and Pediatric Nonalcoholic Fatty Liver Disease Diagnosis. Journal of Pediatric Gastroenterology and Nutrition 2017; 65(5) doi: 10.1097/MPG.0000000000001668
7
Denisa Pilic. Praktisches Vorgehen zur Abklärung erhöhter Leberwerte. Pädiatrie 2022; 34(2) doi: 10.1007/s15014-022-3980-x
8
Víctor Fernández Ventureira, Ignacio Ros Arnal, Gerardo Rodríguez Martínez, Beatriz García Rodríguez, Ruth García Romero, Eduardo Ubalde Sainz. Evaluation of liver function tests in the paediatric patient. Anales de Pediatría (English Edition) 2021; 94(6) doi: 10.1016/j.anpede.2020.06.014
9
Linnea Aitokari, Pauliina Hiltunen, Heini Huhtala, Kalle Kurppa, Laura Kivelä. Measurement practices of alanine aminotransferase in children: Temporal changes and etiology for increased values. Journal of Pediatric Gastroenterology and Nutrition 2024; 78(6) doi: 10.1002/jpn3.12167
10
Mohit Kehar, Robert J. Klaassen, Consolato M. Sergi. Heterozygous missense mutation of the fibrinogen gene associated with cryptogenic liver disease in a 15-months-old Canadian caucasian child. Ultrastructural Pathology 2025; 49(2) doi: 10.1080/01913123.2024.2447853
11
Sarah Bussler, Mandy Vogel, Diana Pietzner, Kristian Harms, Theresa Buzek, Melanie Penke, Norman Händel, Antje Körner, Ulrich Baumann, Wieland Kiess, Gunter Flemming. New pediatric percentiles of liver enzyme serum levels (alanine aminotransferase, aspartate aminotransferase, γ‐glutamyltransferase): Effects of age, sex, body mass index, and pubertal stage. Hepatology 2018; 68(4) doi: 10.1002/hep.29542
12
Ana Colmenero Hernández, Ana Posada Ayala, Paula Tagle Hernández. Hypertransaminasemia as an initial manifestation of muscular dystrophy in childhood. Medicina Clínica (English Edition) 2026; 166(5) doi: 10.1016/j.medcle.2026.107392
13
Yu.M. Stepanov, N.Yu. Zavhorodnia, O.Yu. Zavhorodnia. 1. GASTROENTEROLOGY 2021; 55(1) doi: 10.22141/2308-2097.55.1.2021.229435
14
Aslıhan SANRI, Ceyda TUNA KIRSAÇLIOĞLU, Emre SANRI, Tülin Revide ŞAYLI. Etiological evaluation of the elevated transaminases in children. Cumhuriyet Medical Journal 2020;  doi: 10.7197/cmj.vi.593477
15
Dieter Furthner, Daniel Weghuber, Christopher Dalus, Andreas Lukas, Hannah N. Stundner-Ladenhauf, Harald Mangge, Thomas Pixner. Nonalcoholic Fatty Liver Disease in Children with Obesity: Narrative Review and Research Gaps. Hormone Research in Paediatrics 2022; 95(2) doi: 10.1159/000518595
16
ELAINE S. XIE, NIKHIL PAI, MICHELLE BATTHISH. Limited GPA and Alpha-1 Antitrypsin Deficiency in a Pediatric Patient. The Journal of Rheumatology 2019; 46(5) doi: 10.3899/jrheum.180979
17
Ignacio Ros Arnal, Joaquín Reyes Andrade, María Mercadal Hally, Luis Carlos Blesa Baviera, Diana García Tirado, Samuel Héctor Campuzano Martín, Estela de la Calle Navarro, Ana María Vegas Álvarez. Diagnostic action against hypertransaminasemia in paediatrics: Consensus document of Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica (SEGHNP), Asociación Española de Pediatría de Atención Primaria (AEPap) and Sociedad Española de Pediatría de Atención Primaria (SEPEAP). Anales de Pediatría (English Edition) 2022; 96(5) doi: 10.1016/j.anpede.2022.04.009
18
Resthie R. Putri, Thomas Casswall, Emilia Hagman. Prevalence of increased transaminases and its association with sex, age, and metabolic parameters in children and adolescents with obesity – a nationwide cross-sectional cohort study. BMC Pediatrics 2021; 21(1) doi: 10.1186/s12887-021-02747-4
19
Mario Giordano, Onofrio Iacoviello, Luisa Santangelo, Marida Martino, Diletta Torres, Vincenza Carbone, Gaia Scavia, Daniela Loconsole, Maria Chironna, Fernanda Cristofori, Ruggiero Francavilla. Gastrointestinal involvement in STEC-associated hemolytic uremic syndrome: 10 years in a pediatric center. Pediatric Nephrology 2024; 39(6) doi: 10.1007/s00467-023-06258-5
20
Ignacio Ros Arnal, Joaquín Reyes Andrade, María Mercadal Hally, Luis Carlos Blesa Baviera, Diana García Tirado, Samuel Héctor Campuzano Martín, Estela de la Calle Navarro, Ana María Vegas Álvarez. Actuación diagnóstica ante hipertransaminasemia en pediatría: documento de consenso de Sociedad Española de Gastroenterología, Hepatología y Nutrición Pediátrica (SEGHNP), Asociación Española de Pediatría de Atención Primaria (AEPap) y Sociedad Española de Pediatría de Atención Primaria (SEPEAP). Anales de Pediatría 2022; 96(5) doi: 10.1016/j.anpedi.2022.04.002
21
Zhisheng Wei, Yeqing Huang, Aiqun Liu, Shengpeng Diao, Qingyun Yu, Zhongxing Peng, Mingfan Hong. Mutational characterization of ATP7B gene in 103 Wilson’s disease patients from Southern China. NeuroReport 2014; 25(14) doi: 10.1097/WNR.0000000000000216
22
Resthie R. Putri. The evolving landscape of pediatric obesity and metabolic dysfunction-associated steatotic liver disease. Frontiers in Pediatrics 2025; 13 doi: 10.3389/fped.2025.1675713
23
Víctor Fernández Ventureira, Ignacio Ros Arnal, Gerardo Rodríguez Martínez, Beatriz García Rodríguez, Ruth García Romero, Eduardo Ubalde Sainz. Evaluación del seguimiento de niños con hallazgo de hipertransaminasemia. Anales de Pediatría 2021; 94(6) doi: 10.1016/j.anpedi.2020.06.019
24
Franco Curci, Mariangela Stinco, Simona Carrera, Chiara Rubino, Giuseppe Indolfi. Diagnostic approach for children with increased serum concentrations of aminotransferases. Global Pediatrics 2024; 7 doi: 10.1016/j.gpeds.2023.100118
25
Christine Yang, Brandon Perumpail, Eric Yoo, Aijaz Ahmed, John Kerner Jr.. Nutritional Needs and Support for Children with Chronic Liver Disease. Nutrients 2017; 9(10) doi: 10.3390/nu9101127
26
Priyanka Udawat, Shambhavi -, S Sitaraman. Clinico-etiological profile of raised aminotransferases in hospitalized children with liver disease and correlation with their severity level. Indian Journal of Child Health 2017; 4(3) doi: 10.32677/IJCH.2017.v04.i03.020
27
Le Anh Tuan Pham, Trong Tue Nguyen, Hoang Bich Nga Le, Dat Quoc Tran, Cam Tu Ho, Thinh Huy Tran, Van Thanh Ta, The Hung Bui, Van Khanh Tran. Genetic analysis of 55 northern Vietnamese patients with Wilson disease: seven novel mutations in ATP7B. Journal of Genetics 2017; 96(6) doi: 10.1007/s12041-017-0857-9
28
Ana Colmenero Hernández, Ana Posada Ayala, Paula Tagle Hernández. Hipertransaminasemia como dato inicial de una distrofia muscular en edad pediátrica. Medicina Clínica 2026; 166(5) doi: 10.1016/j.medcli.2026.107392
29
Moeen ud din Khan Khalil, Syed Kazim Shah Bukhari, Syed Murtaza Shah Bukhari, Mian Zia Shah, Mian Raza Shah. Correlation between computed tomography findings and liver function parameters in chronic liver disease. Journal of Shalamar Medical & Dental College - JSHMDC 2025; 6(1) doi: 10.53685/jshmdc.v6i1.308
30
Taoufik Ben Houmich, Brahim Admou. Celiac disease: Understandings in diagnostic, nutritional, and medicinal aspects. International Journal of Immunopathology and Pharmacology 2021; 35 doi: 10.1177/20587384211008709
31
Demet Teker Düztaş, Aydın Bozkaya. Etiological and clinical characteristics of childhood hypertransaminasemia: a retrospective study. Turkish Journal of Clinics and Laboratory 2026; (1) doi: 10.18663/tjcl.1832567
32
Henrik Arnell, Björn Fischler. Pediatric Hepatology and Liver Transplantation. 2019;  doi: 10.1007/978-3-319-96400-3_4
33
Claudio Veropalumbo, Angelo Campanozzi, Fabiola De Gregorio, Antonio Correra, Valeria Raia, Pietro Vajro. Shwachman-Diamond syndrome with autoimmune-like liver disease and enteropathy mimicking celiac disease. Clinics and Research in Hepatology and Gastroenterology 2015; 39(1) doi: 10.1016/j.clinre.2014.06.017
34
Piotr Socha, Pietro Vajro, Dirk Lefeber, Maciej Adamowicz, Stuart Tanner. Search for rare liver diseases: The case of glycosylation defects mimicking Wilson Disease ->. Clinics and Research in Hepatology and Gastroenterology 2014; 38(4) doi: 10.1016/j.clinre.2014.04.012
35
Maria Anna Siano, Claudia Mandato, Lucia Nazzaro, Gennaro Iannicelli, Gian Paolo Ciccarelli, Ferdinando Barretta, Cristina Mazzaccara, Margherita Ruoppolo, Giulia Frisso, Carlo Baldi, Salvatore Tartaglione, Francesco Di Salle, Daniela Melis, Pietro Vajro. Hepatic Presentation of Late-Onset Multiple Acyl-CoA Dehydrogenase Deficiency (MADD): Case Report and Systematic Review. Frontiers in Pediatrics 2021; 9 doi: 10.3389/fped.2021.672004
36
Diletta Valentini, Anna Alisi, Chiara di Camillo, Maria Rita Sartorelli, Annalisa Crudele, Andrea Bartuli, Valerio Nobili, Alberto Villani. Nonalcoholic Fatty Liver Disease in Italian Children with Down Syndrome: Prevalence and Correlation with Obesity-Related Features. The Journal of Pediatrics 2017; 189 doi: 10.1016/j.jpeds.2017.05.077
37
J.I. Fortea, C. Rodríguez de Lope, S. Álvarez, J. Crespo Gracía. Protocolo diagnóstico de la elevación aguda de las transaminasas en el paciente inmunocompetente. Medicine - Programa de Formación Médica Continuada Acreditado 2016; 12(9) doi: 10.1016/j.med.2016.04.007
38
Carolyne Ghobrial, Nehal Abdelhamid, Hanaa El-Karaksy. Incidental hypertransaminasemia in children: Potential delay in diagnosis of muscle disease. Egyptian Pediatric Association Gazette 2018; 66(4) doi: 10.1016/j.epag.2018.09.002
39
Joana Meneses Costa, Sara Martins Pinto, Ermelinda Santos-Silva, Helena Moreira-Silva. Incidental hypertransaminasemia in children—a stepwise approach in primary care. European Journal of Pediatrics 2023; 182(4) doi: 10.1007/s00431-023-04825-4
40
Patrizia Burra, Calogero Cammà, Pietro Invernizzi, Fabio Marra, Maurizio Pompili. Does the hepatologist still need to rely on aminotransferases in clinical practice? A reappraisal of the role of a classic biomarker in the diagnosis and clinical management of chronic liver diseases. Annals of Hepatology 2025; 30(1) doi: 10.1016/j.aohep.2025.101900
41
Luca Pierri, Pasquale Saggese, Salvatore Guercio Nuzio, Jacopo Troisi, Martina Di Stasi, Marco Poeta, Riccardo Savastano, Giovanna Marchese, Roberta Tarallo, Grazia Massa, Vincenzo Ciccone, Doreen Ziegenhardt, Pierpaolo Cavallo, Ina Bergheim, Alessandro Weisz, Pietro Vajro. Relations of gut liver axis components and gut microbiota in obese children with fatty liver: A pilot study. Clinics and Research in Hepatology and Gastroenterology 2018; 42(4) doi: 10.1016/j.clinre.2018.03.015
42
Brahim Admou, Wissal Zkhiri, Morad Guennouni, Raja Hazime. Maladie cœliaque : une pathologie au carrefour de la médecine, de la diététique et de la pharmaceutique. La Presse Médicale Formation 2021; 2(6) doi: 10.1016/j.lpmfor.2021.10.005
43
Valeria Casotti, Lorenzo D’Antiga. Pediatric Hepatology and Liver Transplantation. 2019;  doi: 10.1007/978-3-319-96400-3_1
44
Naoki Tanaka, Takefumi Kimura, Naoyuki Fujimori, Yasuyuki Ichise, Kenji Sano, Akira Horiuchi. Non-alcoholic fatty liver disease later diagnosed as myotonic dystrophy. World Journal of Hepatology 2020; 12(9): 685-692 doi: 10.4254/wjh.v12.i9.685
45
Meryem KEÇELİ BAŞARAN, Tuba ÇİÇEK. Causes of hypertransaminasemia in children, single-center experience. Family Practice and Palliative Care 2021; 6(1) doi: 10.22391/fppc.787707
46
Annarita BONGIOVANNI, Massimo SPINA, Maria PAPALE, Ilaria BRAMBILLA, Amelia LICARI, Giuseppe F. PARISI, Salvatore LEONARDI. Hypertransaminasemia in children is not always as simple as it seems. Minerva Pediatrics 2021; 73(3) doi: 10.23736/S2724-5276.19.05514-2
47
Sophia Gunzer, Andreas Kraus, Inka Buchroth, Marianne Grüneberg, Cordula Westermann, Saskia Biskup, Janine Reunert, Inga Grünewald, Thorsten Marquardt. Hypertransaminasemia and liver fibrosis associated with haptoglobin retention and anhaptoglobinemia in a paediatric patient. Liver International 2021; 41(10) doi: 10.1111/liv.15029
48
Claudia Mandato, Pietro Vajro. Isolated aspartate aminotransferase elevation: Is it liver disease or what else?. Acta Paediatrica 2022; 111(3) doi: 10.1111/apa.16213
49
Diane Hsu, Rohit Josyabhatla, Iona M. Monteiro. Case 3: Persistent Elevated Transaminase Levels in a 9-year-old Boy. Pediatrics in Review 2019; 40(12) doi: 10.1542/pir.2018-0022
50
Pamela Paglia, Lucia Nazzaro, Anna Giulia Elena De Anseris, Milena Lettieri, Rossella Colantuono, Maria Chiara Rocco, Maria Anna Siano, Nicola Biffaro, Pietro VAJRO. Atypically Protracted Course of Liver Involvement in Kawasaki Disease. Case Report and Literature Review. Pediatric Reports 2021; 13(3) doi: 10.3390/pediatric13030044
51
Thierry Lamireau, Valérie McLin, Valério Nobili, Pietro Vajro. A practical approach to the child with abnormal liver tests. Clinics and Research in Hepatology and Gastroenterology 2014; 38(3) doi: 10.1016/j.clinre.2014.02.010
52
Magnus J Johansen, Julie Gade, Stefan Stender, Christine Frithioff-Bøjsøe, Morten A V Lund, Elizaveta Chabanova, Henrik S Thomsen, Oluf Pedersen, Cilius E Fonvig, Torben Hansen, Jens-Christian Holm. The Effect of Overweight and Obesity on Liver Biochemical Markers in Children and Adolescents. The Journal of Clinical Endocrinology & Metabolism 2020; 105(2) doi: 10.1210/clinem/dgz010
53
Renata Alfani, Edoardo Vassallo, Anna Giulia De Anseris, Lucia Nazzaro, Ida D'Acunzo, Carolina Porfito, Claudia Mandato, Pietro Vajro. Pediatric Fatty Liver and Obesity: Not Always Just a Matter of Non-Alcoholic Fatty Liver Disease. Children 2018; 5(12) doi: 10.3390/children5120169
54
Yoon Lee, Dae Yong Yi, Yoo Min Lee, So Yoon Choi, You Jin Choi, Kyung Jae Lee. A Multicenter Study of Real-world Practice for Management of Abnormal Liver Function Tests in Children with Acute Infectious Diseases. Journal of Korean Medical Science 2021; 36(47) doi: 10.3346/jkms.2021.36.e310
55
Seracettin Eğin, Kurtuluş Açıksarı, Gülçin Ercan, Fatih A. Aydın, Esra Aycan Üstyol, Mediha Eser, Gamze Tanrıverdi, Hakan Teoman Yanar. Effects of pentoxifylline on oxidative stress in rats with abdominal compartment syndrome model. International Journal of Surgery Open 2016; 5 doi: 10.1016/j.ijso.2016.09.001
56
Ruchi Mantri, S. B. Bavdekar, Sushma U. Save. Congenital Hypothyroidism: An Unusual Combination of Biochemical Abnormalities. Case Reports in Pediatrics 2016; 2016 doi: 10.1155/2016/2678578
57
Wolfgang Kamin, Ortwin Adams, Peter Kardos, Heinrich Matthys, Norbert Meister, Christian P. Strassburg. Liver Involvement in Acute Respiratory Infections in Children and Adolescents – Results of a Non-interventional Study. Frontiers in Pediatrics 2022; 10 doi: 10.3389/fped.2022.840008
58
Angelo Colucci, Maria Chiara Rocco, Anna Giulia Elena De Anseris, Lucia Nazzaro, Pietro Vajro, Claudia Mandato. Pediatric vs. adult NAFLD to MAFLD transition: a welcome but tangled path. Exploration of Medicine 2021;  doi: 10.37349/emed.2021.00051
59
Maria Grazia Clemente, Claudia Mandato, Marco Poeta, Pietro Vajro. Pediatric non-alcoholic fatty liver disease: Recent solutions, unresolved issues, and future research directions. World Journal of Gastroenterology 2016; 22(36): 8078-8093 doi: 10.3748/wjg.v22.i36.8078
60
Karen Van Hoeve, Djalila Mekahli, Eva Morava, Elena Levtchenko, Peter Witters. Liver involvement in kidney disease and vice versa. Pediatric Nephrology 2018; 33(6) doi: 10.1007/s00467-017-3715-3
61
Yunfei Luo, Hui Lin. Inflammation initiates a vicious cycle between obesity and nonalcoholic fatty liver disease. Immunity, Inflammation and Disease 2021; 9(1) doi: 10.1002/iid3.391
62
U. Baumann. Differenzialdiagnostik bei persistierender Erhöhung der Transaminasenkonzentrationen. Monatsschrift Kinderheilkunde 2015; 163(2) doi: 10.1007/s00112-014-3267-6
63
Pietro Vajro, Katarzyna Zielinska, Bobby G. Ng, Marco Maccarana, Per Bengtson, Marco Poeta, Claudia Mandato, Elisa D’Acunto, Hudson H. Freeze, Erik A. Eklund. Three unreported cases of TMEM199-CDG, a rare genetic liver disease with abnormal glycosylation. Orphanet Journal of Rare Diseases 2018; 13(1) doi: 10.1186/s13023-017-0757-3
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