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For: Tang XP, Tang GD, Fang CY, Liang ZH, Zhang LY. Effects of ginsenoside Rh2 on growth and migration of pancreatic cancer cells. World J Gastroenterol 2013; 19(10): 1582-1592 [PMID: 23538603 DOI: 10.3748/wjg.v19.i10.1582]
URL: https://www.wjgnet.com/1007-9327/full/v19/i10/1582.htm
Number Citing Articles
1
Qing Jin, Cunzhi Lin, Xinhong Zhu, Yiwei Cao, Caihong Guo, Lijun Wang. 125I seeds irradiation inhibits tumor growth and induces apoptosis by Ki-67, P21, survivin, livin and caspase-9 expression in lung carcinoma xenograftsRadiation Oncology 2020; 15(1) doi: 10.1186/s13014-020-01682-5
2
H. Dommisch, J. Winter, W. Götz, J. Miesen, A. Klein, L. Hierse, J. Deschner, A. Jäger, J. Eberhard, S. Jepsen. Effect of growth factors on antimicrobial peptides and pro-inflammatory mediators during wound healingClinical Oral Investigations 2015; 19(2): 209 doi: 10.1007/s00784-014-1239-9
3
Yan Chen, Hong Shang, Shunli Zhang, Xiaohong Zhang. Retracted: Ginsenoside Rh2 inhibits proliferation and migration of medulloblastoma Daoy by down‐regulation of microRNA‐31Journal of Cellular Biochemistry 2018; 119(8): 6527 doi: 10.1002/jcb.26716
4
Muhammad Zubair Siddiqi, Chang-Hao Cui, Seul-Ki Park, Nam Soo Han, Sun-Chang Kim, Wan-Taek Im, Hua Zhou. Comparative analysis of the expression level of recombinant ginsenoside-transforming β-glucosidase in GRAS hosts and mass production of the ginsenoside Rh2-MixPLOS ONE 2017; 12(4): e0176098 doi: 10.1371/journal.pone.0176098
5
Xun Li, Shifeng Chu, Meiyu Lin, Yan Gao, Yingjiao Liu, Songwei Yang, Xin Zhou, Yani Zhang, Yaomei Hu, Huiqin Wang, Naihong Chen. Anticancer property of ginsenoside Rh2 from ginsengEuropean Journal of Medicinal Chemistry 2020; 203: 112627 doi: 10.1016/j.ejmech.2020.112627
6
YingMin Qu, Feihu Zhao, Xinyue Wang, Jinyun Liu, Jingmei Li, Zhengxun Song, Zuobin Wang. Cardiomyocyte contractile force changes in response to AGRWE detected by AFMMicro & Nano Letters 2019; 14(5): 511 doi: 10.1049/mnl.2018.5458
7
Xiang Li, Nan Wang, Yutong Wu, Yidan Liu, Ruoyu Wang. ALDH6A1 weakens the progression of colon cancer via modulating the RAS/RAF/MEK/ERK pathway in cancer cell linesGene 2022; 842: 146757 doi: 10.1016/j.gene.2022.146757
8
Keke LI, Zhongyu LI, Lei Men, Wei LI, Xiaojie GONG. Potential of ginsenoside Rh2and its derivatives as anti-cancer agentsChinese Journal of Natural Medicines 2022; 20(12): 881 doi: 10.1016/S1875-5364(22)60193-6
9
Hwa-Seung Yoo, Mi-Kyung Jeong, Chong-Kwan Cho. General and Genetic Toxicology of Enzyme-Treated Ginseng ExtractJournal of Pharmacopuncture 2016; 19(3): 213 doi: 10.3831/KPI.2016.19.022
10
Ting Xia, Jiancheng Wang, Yingnan Wang, Yuanyuan Wang, Jianye Cai, Min Wang, Qidan Chen, Jia Song, Ziqi Yu, Wei Huang, Jianpei Fang. Inhibition of autophagy potentiates anticancer property of 20(S)-ginsenoside Rh2 by promoting mitochondria-dependent apoptosis in human acute lymphoblastic leukaemia cellsOncotarget 2016; 7(19): 27336 doi: 10.18632/oncotarget.8285
11
Xuewei Ye, Siran Yu, Ying Liang, Haocai Huang, Xiao-Yuan Lian, Zhizhen Zhang. Bioactive triterpenoid saponins and phenolic compounds against glioma cellsBioorganic & Medicinal Chemistry Letters 2014; 24(22): 5157 doi: 10.1016/j.bmcl.2014.09.087
12
Ting Xia, Ying-Nan Wang, Chuan-Xin Zhou, Li-Mei Wu, Yong Liu, Qian-Hong Zeng, Xiang-Long Zhang, Jia-Hui Yao, Min Wang, Jian-Pei Fang. Ginsenoside Rh2 and Rg3 inhibit cell proliferation and induce apoptosis by increasing mitochondrial reactive oxygen species in human leukemia Jurkat cellsMolecular Medicine Reports 2017; 15(6): 3591 doi: 10.3892/mmr.2017.6459
13
Tereza Cristina da Silva, Bruno Cogliati, Andréia Oliveira Latorre, Gokithi Akisue, Márcia Kazumi Nagamine, Mitsue Haraguchi, Daiane Hansen, Daniel Soares Sanches, Maria Lúcia Zaidan Dagli. Pfaffosidic Fraction fromHebanthe paniculataInduces Cell Cycle Arrest and Caspase-3-Induced Apoptosis in HepG2 CellsEvidence-Based Complementary and Alternative Medicine 2015; 2015: 1 doi: 10.1155/2015/835796
14
Priyanka Singh, Hina Singh, Verónica Castro-Aceituno, Sungeun Ahn, Yeon Ju Kim, Mohamed El-Agamy Farh, Deok Chun Yang. Engineering of mesoporous silica nanoparticles for release of ginsenoside CK and Rh2 to enhance their anticancer and anti-inflammatory efficacy: in vitro studiesJournal of Nanoparticle Research 2017; 19(7) doi: 10.1007/s11051-017-3949-9
15
Jong Dae Park. Chemistry of Korean Foods and BeveragesACS Symposium Series 2019; 1303: 149 doi: 10.1021/bk-2019-1303.ch011
16
Junyu Wu, Guoyi Tang, Chien-Shan Cheng, Ranna Yeerken, Yau-Tuen Chan, Zhiwen Fu, Yi-Chao Zheng, Yibin Feng, Ning Wang. Traditional Chinese medicine for the treatment of cancers of hepatobiliary system: from clinical evidence to drug discoveryMolecular Cancer 2024; 23(1) doi: 10.1186/s12943-024-02136-2
17
Li Yang, Hecun Zou, Yongchao Gao, Junjia Luo, Xiaonv Xie, Wenhui Meng, Honghao Zhou, Zhirong Tan. Insights into gastrointestinal microbiota-generated ginsenoside metabolites and their bioactivitiesDrug Metabolism Reviews 2020; 52(1): 125 doi: 10.1080/03602532.2020.1714645
18
Yi Yang, Yi Nan, Yuhua Du, Wenjing Liu, Na Ning, Guoqing Chen, Qian Gu, Ling Yuan. Ginsenosides in cancer: Proliferation, metastasis, and drug resistanceBiomedicine & Pharmacotherapy 2024; 177: 117049 doi: 10.1016/j.biopha.2024.117049
19
Zhi-Mei You, Liang Zhao, Jing Xia, Qiang Wei, Yu-Min Liu, Xiao-Yan Liu, Di-Long Chen, Jing Li. Down-regulation of Phosphoglucose Isomerase/Autocrine Motility Factor Enhances Gensenoside Rh2 Pharmacological Action on Leukemia KG1α CellsAsian Pacific Journal of Cancer Prevention 2014; 15(3): 1099 doi: 10.7314/APJCP.2014.15.3.1099
20
Shuai Bian, Meichen Liu, Song Yang, Shuyan Lu, Siming Wang, Xueyuan Bai, Daqing Zhao, Jiawen Wang. 20(S)-Ginsenoside Rh2-induced apoptosis and protective autophagy in cervical cancer cells by inhibiting AMPK/mTOR pathwayBioscience, Biotechnology, and Biochemistry 2021; 86(1): 92 doi: 10.1093/bbb/zbab189
21
Luciana Fernández, Ana Lucía Reviglio, Daniel A. Heredia, Gustavo M. Morales, Marisa Santo, Luis Otero, Fabrisio Alustiza, Ana Cecilia Liaudat, Pablo Bosch, Enrique L. Larghi, Andrea B.J. Bracca, Teodoro S. Kaufman. Langmuir-Blodgett monolayers holding a wound healing active compound and its effect in cell culture. A model for the study of surface mediated drug delivery systemsHeliyon 2021; 7(3): e06436 doi: 10.1016/j.heliyon.2021.e06436
22
Wenxin Huang, Liwen Sun, Baihui Wang, Yan Ma, Dahong Yao, Weina Han, Libo Wang. Ginsenosides, potent inhibitors of sialyltransferaseZeitschrift für Naturforschung C 2020; 75(1-2): 41 doi: 10.1515/znc-2019-0150
23
Dan-Dan Wang, Yeon-Ju Kim, Nam In Baek, Ramya Mathiyalagan, Chao Wang, Yan Jin, Xing Yue Xu, Deok-Chun Yang. Glycosyltransformation of ginsenoside Rh2 into two novel ginsenosides using recombinant glycosyltransferase from Lactobacillus rhamnosus and its in vitro applicationsJournal of Ginseng Research 2021; 45(1): 48 doi: 10.1016/j.jgr.2019.11.004
24
Meiyan Li, Dandan Tang, Ting Yang, Die Qian, Runchun Xu. Apoptosis Triggering, an Important Way for Natural Products From Herbal Medicines to Treat Pancreatic CancersFrontiers in Pharmacology 2022; 12 doi: 10.3389/fphar.2021.796300
25
Meng Wang, Shi-Ju Yan, Hong-Tao Zhang, Nan Li, Tao Liu, Ying-Long Zhang, Xiao-Xiang Li, Qiong Ma, Xiu-Chun Qiu, Qing-Yu Fan, Bao-An Ma. Ginsenoside Rh2 enhances the antitumor immunological response of a melanoma mice modelOncology Letters 2017; 13(2): 681 doi: 10.3892/ol.2016.5490
26
Peng Li, Junfeng Ye, Yue Zhang, Ziqi Wang, Sujuan Ren, Xuwen Li, Yongri Jin. Centrifugation free and air-assisted liquid-liquid microextraction based on deep eutectic solvent for determination of rare ginsenosides in Kang'ai injectionMicrochemical Journal 2018; 142: 313 doi: 10.1016/j.microc.2018.07.012
27
Shaoyi Li, Yun Gao, Weining Ma, Wenchang Guo, Gang Zhou, Tianci Cheng, Yunhui Liu. EGFR signaling-dependent inhibition of glioblastoma growth by ginsenoside Rh2Tumor Biology 2014; 35(6): 5593 doi: 10.1007/s13277-014-1739-x
28
Lin Li, Po Sing Leung. Use of herbal medicines and natural products: An alternative approach to overcoming the apoptotic resistance of pancreatic cancerThe International Journal of Biochemistry & Cell Biology 2014; 53: 224 doi: 10.1016/j.biocel.2014.05.021
29
Jianjun Yang, Donghong Yuan, Tongchao Xing, Hongli Su, Shengjun Zhang, Jiansheng Wen, Qiqiang Bai, Dongmei Dang. Ginsenoside Rh2 inhibiting HCT116 colon cancer cell proliferation through blocking PDZ-binding kinase/T-LAK cell-originated protein kinaseJournal of Ginseng Research 2016; 40(4): 400 doi: 10.1016/j.jgr.2016.03.007
30
Sang Yeol Lee. Anti-Metastatic and Anti-Inflammatory Effects of Matrix Metalloproteinase Inhibition by GinsenosidesBiomedicines 2021; 9(2): 198 doi: 10.3390/biomedicines9020198
31
Seun Eui Kim, Myoung-Hoon Lee, Hye-Myoung Jang, Wan-Taek Im, Joontaik Lee, Sang-Hwan Kim, Gwang Joo Jeon. Anticancer activity of ginsenosides Rh2 on various cancer cellsJournal of Animal Reproduction and Biotechnology 2023; 38(3): 131 doi: 10.12750/JARB.38.3.131
32
Ning Guan, Xiaochuan Huo, Zhenxing Zhang, Shoudan Zhang, Junsheng Luo, Wenshi Guo. Ginsenoside Rh2 inhibits metastasis of glioblastoma multiforme through Akt-regulated MMP13Tumor Biology 2015; 36(9): 6789 doi: 10.1007/s13277-015-3387-1
33
Chenchen Li, Huan Gao, Xuemei Feng, Chuyao Bi, Jing Zhang, Jianyuan Yin. Ginsenoside Rh2 impedes proliferation and migration and induces apoptosis by regulating NF‐κB, MAPK, and PI3K/Akt/mTOR signaling pathways in osteosarcoma cellsJournal of Biochemical and Molecular Toxicology 2020; 34(12) doi: 10.1002/jbt.22597
34
Qingchuan Zhang, Bin Hong, Songhua Wu, Tianli Niu. Inhibition of prostatic cancer growth by ginsenoside Rh2Tumor Biology 2015; 36(4): 2377 doi: 10.1007/s13277-014-2845-5
35
Idolo Tedesco, Gian Luigi Russo. Nonvitamin and Nonmineral Nutritional Supplements2019; : 251 doi: 10.1016/B978-0-12-812491-8.00036-9
36
Alice S. T. Wong, Chi-Ming Che, Kar-Wah Leung. Recent advances in ginseng as cancer therapeutics: a functional and mechanistic overviewNatural Product Reports 2015; 32(2): 256 doi: 10.1039/C4NP00080C
37
Hadi Zare-Zardini, Asghar Taheri-Kafrani, Ahmad Amiri, Abdol-Khalegh Bordbar. New generation of drug delivery systems based on ginsenoside Rh2-, Lysine- and Arginine-treated highly porous graphene for improving anticancer activityScientific Reports 2018; 8(1) doi: 10.1038/s41598-017-18938-y
38
An-Sik Chung, Kyeong Mee Park. Studies in Natural Products Chemistry 2016; 50: 131 doi: 10.1016/B978-0-444-63749-9.00004-9
39
Shipeng Li, Wenfeng Han, Qichen He, Yang Wang, Gang Jin, Youcheng Zhang. Ginsenoside Rh2 suppresses colon cancer growth by targeting the miR-150-3p/SRCIN1/Wnt axisActa Biochimica et Biophysica Sinica 2023; 55(4): 633 doi: 10.3724/abbs.2023032
40
Hyun-Jung Park, Hyun Soo Shim, Jeom Yong Kim, Joo Young Kim, Sun Kyu Park, Insop Shim. Ginseng Purified Dry Extract, BST204, Improved Cancer Chemotherapy-Related Fatigue and Toxicity in MiceEvidence-Based Complementary and Alternative Medicine 2015; 2015: 1 doi: 10.1155/2015/197459
41
Yingying Chen, Yuqiang Zhang, Wei Song, Ying Zhang, Xiu Dong, Mingqi Tan. Ginsenoside Rh2 Inhibits Migration of Lung Cancer Cells under Hypoxia via mir-491Anti-Cancer Agents in Medicinal Chemistry 2019; 19(13): 1633 doi: 10.2174/1871520619666190704165205
42
Xin Shi, Ji Yang, Gang Wei. Ginsenoside 20(S)-Rh2 exerts anti-cancer activity through the Akt/GSK3β signaling pathway in human cervical cancer cellsMolecular Medicine Reports 2018;  doi: 10.3892/mmr.2018.8454
43
Xin-Ling He, Xiao-Huang Xu, Jia-Jie Shi, Mingqing Huang, Yitao Wang, Xiuping Chen, Jin-Jian Lu. Anticancer Effects of Ginsenoside Rh2: A Systematic ReviewCurrent Molecular Pharmacology 2021; 15(1): 179 doi: 10.2174/1874467214666210309115105
44
Zhiqing Yang, Tingting Zhao, Hongli Liu, Leida Zhang. Ginsenoside Rh2 inhibits hepatocellular carcinoma through β-catenin and autophagyScientific Reports 2016; 6(1) doi: 10.1038/srep19383
45
Ying Qian, Rongrong Huang, Senlin Li, Rui Xie, Bei Qian, Zijun Zhang, Lei Li, Baotian Wang, Cheng Tian, Jian Yang, Ming Xiang. Ginsenoside Rh2 reverses cyclophosphamide-induced immune deficiency by regulating fatty acid metabolismJournal of Leukocyte Biology 2019; 106(5): 1089 doi: 10.1002/JLB.2A0419-117R
46
Jun Qian, Jing Li, Jian-Guang Jia, Xin Jin, Da-Jun Yu, Chen-Xu Guo, Bo Xie, Li-Yu Qian. Ginsenoside-Rh2 Inhibits Proliferation and Induces Apoptosis of Human Gastric Cancer SGC-7901 Side Population CellsAsian Pacific Journal of Cancer Prevention 2016; 17(4): 1817 doi: 10.7314/APJCP.2016.17.4.1817
47
Shaoyi Li, Wenchang Guo, Yun Gao, Yunhui Liu. Ginsenoside Rh2 inhibits growth of glioblastoma multiforme through mTorTumor Biology 2015; 36(4): 2607 doi: 10.1007/s13277-014-2880-2
48
Shaoyi Li, Yun Gao, Weining Ma, Tianci Cheng, Yunhui Liu. Ginsenoside Rh2 inhibits invasiveness of glioblastoma through modulation of VEGF-ATumor Biology 2016; 37(12): 15477 doi: 10.1007/s13277-015-3759-6
49
Dan Liu, Hao Wang, Zhangxu Zhou, Xiaohan Mao, Ziqian Ye, Zhilun Zhang, Shixin Tu, Yanlai Zhang, Xue Cai, Xin Lan, Zhang Zhang, Baoru Han, Guowei Zuo. Integrated bioinformatic analysis and experiment confirmation of the antagonistic effect and molecular mechanism of ginsenoside Rh2 in metastatic osteosarcomaJournal of Pharmaceutical and Biomedical Analysis 2021; 201: 114088 doi: 10.1016/j.jpba.2021.114088
50
Jin Hee Kim, Miseon Kim, Sun-Mi Yun, Seul Lee, Jae Hong No, Dong Hoon Suh, Kidong Kim, Yong Beom Kim. Ginsenoside Rh2 induces apoptosis and inhibits epithelial-mesenchymal transition in HEC1A and Ishikawa endometrial cancer cellsBiomedicine & Pharmacotherapy 2017; 96: 871 doi: 10.1016/j.biopha.2017.09.033
51
Fei Gao, Jin-Ming Zhang, Zhan-Guo Wang, Wei Peng, Hui-Ling Hu, Chao-Mei Fu. Biotransformation, a Promising Technology for Anti-cancer Drug DevelopmentAsian Pacific Journal of Cancer Prevention 2013; 14(10): 5599 doi: 10.7314/APJCP.2013.14.10.5599
52
Sun Xiaodan, Cheng Ying. Role of ginsenoside Rh2 in tumor therapy and tumor microenvironment immunomodulationBiomedicine & Pharmacotherapy 2022; 156: 113912 doi: 10.1016/j.biopha.2022.113912
53
Ting Xia, Jin Zhang, Chuanxin Zhou, Yu Li, Wenhui Duan, Bo Zhang, Min Wang, Jianpei Fang. 20(S)-Ginsenoside Rh2 displays efficacy against T-cell acute lymphoblastic leukemia through the PI3K/Akt/mTOR signal pathwayJournal of Ginseng Research 2020; 44(5): 725 doi: 10.1016/j.jgr.2019.07.003
54
Xia He, Ning Wang, Yu Zhang, Xiaobo Huang, Yi Wang. The therapeutic potential of natural products for treating pancreatic cancerFrontiers in Pharmacology 2022; 13 doi: 10.3389/fphar.2022.1051952
55
Benito Soto-Blanco. Herbal Biomolecules in Healthcare Applications2022; : 239 doi: 10.1016/B978-0-323-85852-6.00021-4
56
QINGQIANG SHI, JING LI, ZIQIANG FENG, LVCUI ZHAO, LIAN LUO, ZHIMEI YOU, DANYANG LI, JING XIA, GUOWEI ZUO, DILONG CHEN. Effect of ginsenoside Rh2 on the migratory ability of HepG2 liver carcinoma cells: Recruiting histone deacetylase and inhibiting activator protein 1 transcription factorsMolecular Medicine Reports 2014; 10(4): 1779 doi: 10.3892/mmr.2014.2392
57
Alexander Popov, Anna Klimovich, Olga Styshova, Alexander Tsybulsky, Dmitry Hushpulian, Andrey Osipyants, Anna Khristichenko, Sergey Kazakov, Manuj Ahuja, Navneet Kaidery, Bobby Thomas, Vladimir Tishkov, Abraham Brown, Irina Gazaryan, Andrey Poloznikov. Probable Mechanisms of Doxorubicin Antitumor Activity Enhancement by Ginsenoside Rh2Molecules 2022; 27(3): 628 doi: 10.3390/molecules27030628
58
Guanqun Ge, Yan Yan, Hui Cai. Ginsenoside Rh2 Inhibited Proliferation by Inducing ROS Mediated ER Stress Dependent Apoptosis in Lung Cancer CellsBiological & Pharmaceutical Bulletin 2017; 40(12): 2117 doi: 10.1248/bpb.b17-00463
59
Lei Wu, Lin Bai, Wenshu Dai, Yaping Wu, Pengjun Xi, Jie Zhang, Lily Zheng. Ginsenoside Rg3: A Review of its Anticancer Mechanisms and Potential Therapeutic ApplicationsCurrent Topics in Medicinal Chemistry 2024; 24(10): 869 doi: 10.2174/0115680266283661240226052054