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For: Huang HL, Wang YJ, Zhang QY, Liu B, Wang FY, Li JJ, Zhu RZ. Hepatoprotective effects of baicalein against CCl4-induced acute liver injury in mice. World J Gastroenterol 2012; 18(45): 6605-6613 [PMID: 23236235 DOI: 10.3748/wjg.v18.i45.6605]
URL: https://www.wjgnet.com/1007-9327/full/v18/i45/6605.htm
Number Citing Articles
1
Hai-Guang Xin, Bei-Bei Zhang, Zhi-Qin Wu, Xiao-Feng Hang, Wen-Sheng Xu, Wu Ni, Rui-Qi Zhang, Xiao-Hui Miao. Treatment with baicalein attenuates methionine−choline deficient diet-induced non-alcoholic steatohepatitis in rats. European Journal of Pharmacology 2014; 738 doi: 10.1016/j.ejphar.2014.06.006
2
Jiaming Liu, Yaoyang Fu, Hao Zhang, Jindan Wang, Jing Zhu, Yaqi Wang, Yuegui Guo, Guocan Wang, Tianqi Xu, Maoping Chu, Fangyan Wang. The hepatoprotective effect of the probiotic Clostridium butyricum against carbon tetrachloride-induced acute liver damage in mice. Food & Function 2017; 8(11) doi: 10.1039/C7FO00355B
3
Sathish Kumar Mungamuri, Yamini Javvadi. Phytochemicals Targeting Tumor Microenvironment in Gastrointestinal Cancers. 2020;  doi: 10.1007/978-3-030-48405-7_12
4
Jessica K. W. Tsang, Susanne A. Wolf, Inga M. Pompoes, Antonia M. Joussen, Wai Ching Lam, Di Yang, Amy C. Y. Lo. Potential Effects of Nutraceuticals in Retinopathy of Prematurity. Life 2021; 11(2) doi: 10.3390/life11020079
5
Amirhossein Nafari, Abbas Sahebghadam Lotfi, Seyed Alireza Mesbah-Namin. The role of miR-30b-3p and miR-3162-3p in the progression and regression of hepatic fibrosis: insights from experimental and bioinformatics analyses. Comparative Clinical Pathology 2024; 34(1) doi: 10.1007/s00580-024-03620-3
6
Po-Yuan Ke, Chih-Wei Chang, Yuan-Chao Hsiao. Baicalein Activates Parkin-Dependent Mitophagy through NDP52 and OPTN. Cells 2022; 11(7) doi: 10.3390/cells11071132
7
Bolin Zhao, Kai Liu, Xing Liu, Qiuxia Li, Zhibei Li, Jingjing Xi, Fan Xie, Xiaofang Li. Plant‐derived flavonoids are a potential source of drugs for the treatment of liver fibrosis. Phytotherapy Research 2024; 38(6) doi: 10.1002/ptr.8193
8
Yan Cui, Zihan Li, Lina Ni, Sujun Yu, Xiao Shan, Penghui Hu, Zemin Ji, Weijia Jing, Yanzhao Zhou, Baochen Wang, Hongyuan Dong, Jinxue Zhou, Keliang Xie, Qiujing Yu. Induction of MTHFD2 in Macrophages Inhibits Reactive Oxygen Species–mediated NF-κB Activation and Protects against Inflammatory Responses. The Journal of Immunology 2024; 212(8) doi: 10.4049/jimmunol.2300209
9
Arnaud Fondjo Kouam, Brice Ayissi Owona, Rodrigue Fifen, Frédéric Nico Njayou, Paul Fewou Moundipa. Inhibition of CYP2E1 and activation of Nrf2 signaling pathways by a fraction from Entada africana alleviate carbon tetrachloride-induced hepatotoxicity. Heliyon 2020; 6(8) doi: 10.1016/j.heliyon.2020.e04602
10
Jia-Yi Feng, Yan-Qing Xie, Peng Zhang, Qian Zhou, Afsar Khan, Zhi-Hong Zhou, Xian-Song Xia, Lu Liu. Hepatoprotective Polysaccharides from Geranium wilfordii: Purification, Structural Characterization, and Their Mechanism. Molecules 2022; 27(11) doi: 10.3390/molecules27113602
11
Babatunji Oyinloye, Foluso Osunsanmi, Basiru Ajiboye, Oluwafemi Ojo, Abidemi Kappo. Modulatory Effect of Methanol Extract of Piper guineense in CCl4-Induced Hepatotoxicity in Male Rats. International Journal of Environmental Research and Public Health 2017; 14(9) doi: 10.3390/ijerph14090955
12
Jingjing Liu, Yulin Wu, Yongfu Wang, Xiaoli Wu, Yucui Li, Changjun Gao, Yuhong Liu, Qian Zhang, Jian Cai, Ziren Su. Hepatoprotective effect of polysaccharide isolated from Sonneratia apetala fruits on acetaminophen-induced liver injury mice. Journal of Functional Foods 2021; 86 doi: 10.1016/j.jff.2021.104685
13
Hanan Y. Aati, Mahmoud Emam, Jawaher Al-Qahtani, Sultan Aati, Abdulrahman Aati, Juergen Wanner, Mohamed M. Seif. Chemical Composition of Tagetes patula Flowers Essential Oil and Hepato-Therapeutic Effect against Carbon Tetrachloride-Induced Toxicity (In-Vivo). Molecules 2022; 27(21) doi: 10.3390/molecules27217242
14
V. A. Prikhodko, T. M. Matuzok, V. E. Karev, A. B. Izotova, S. V. Okovityi. Adaptation of the Quick – Pytel test protocol for the assessment of liver antitoxic function in mice. Drug development & registration 2026; 15(1) doi: 10.33380/2305-2066-2026-15-1-2256
15
M. V. Haretskaya, V. M. Sheibak. Hepatoprotective properties of taurine during carbon tetrachloride intoxication. Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 2014; 8(4) doi: 10.1134/S1990750814040039
16
Minggang Wang, Qinglan Shi, Rongzhen Zhang, Hua Qiu, Dewen Mao, Fuli Long, Kuttulebbai N. S. Sirajudeen. Herbal Compound “Jiedu Huayu” Reduces Liver Injury in Rats via Regulation of IL‐2, TLR4, and PCNA Expression Levels. Evidence-Based Complementary and Alternative Medicine 2017; 2017(1) doi: 10.1155/2017/9819350
17
Liang Shi, Zhanxia Hao, Shaobo Zhang, Mengjuan Wei, Bin Lu, Zhengtao Wang, Lili Ji. Baicalein and baicalin alleviate acetaminophen-induced liver injury by activating Nrf2 antioxidative pathway: The involvement of ERK1/2 and PKC. Biochemical Pharmacology 2018; 150 doi: 10.1016/j.bcp.2018.01.026
18
Chongshan Dai, Hui Li, Yang Wang, Shusheng Tang, Tony Velkov, Jianzhong Shen. Inhibition of Oxidative Stress and ALOX12 and NF-κB Pathways Contribute to the Protective Effect of Baicalein on Carbon Tetrachloride-Induced Acute Liver Injury. Antioxidants 2021; 10(6) doi: 10.3390/antiox10060976
19
Hamid Ali, Nurul Kabir, Muhammad Raza Shah, Akhtar Muhammad, Safdar Ali, Shahab Mehmood, Amjad Ali, Abid Ali, Azra Jahan. Hepatoprotective activity of viscosine is mediated by attenuation of hepatic macrophages and iNOS expression in CCl4-intoxicated rats. Toxicology Research 2016; 5(6) doi: 10.1039/C6TX00165C
20
Wen-Xue Wang, Fang Liu, Jin-Yang Li, Jie Xue, Yan-Tuan Li, Ren-Min Liu. A cocrystal for effectively reducing the hepatotoxicity of ethionamide. Journal of Molecular Structure 2021; 1243 doi: 10.1016/j.molstruc.2021.130729
21
Bimi Zhang, Dehong Tan, Bing Bai, Yin He, Shujuan Ji. γ-Glutamyl-S-allyl-cysteine inhibits hepatic stellate cell proliferation and collagen secretion via a proapoptotic mechanism. European Food Research and Technology 2015; 240(6) doi: 10.1007/s00217-015-2453-7
22
Amani A. Sorour, Rania G. Aly, Hanan M. Ragab, Ahmed Wahid. Structure Modification Converts the Hepatotoxic Tacrine into Novel Hepatoprotective Analogs. ACS Omega 2024; 9(2) doi: 10.1021/acsomega.3c07126
23
Therapeutic effects of ethanol extract from Erythrina fusca Lour. fruit against carbon tetrachloride-induced liver injury in mice. International Journal of Agricultural Technology 2025; 21(6) doi: 10.63369/ijat.2025.21.6.2429-2442
24
Jiao Liu, Shengjie Zhang, Hongchao Cao, Hui Wang, Chao Sun, Shengnan Liu, Shuxian Yu, Yan Li, Wei Liu, Hui Wang, Jingjing Jiang, Hao Ying. Deficiency of p38α in macrophage ameliorates d‐galactosamine/TNF‐α‐induced acute liver injury in mice. The FEBS Journal 2017; 284(24) doi: 10.1111/febs.14294
25
Shu Jia, Qi Chen, Jingyi Wu, Xiaokun Yao, Jingping Shao, Xiaoyan Cheng, Congcong Zhang, Danwei Cen, Yuqiang Wang, Zhihong Shen, Luchen Shan, Xiaomin Yao. Danshensu derivative ADTM ameliorates CCl4‑induced acute liver injury in mice through inhibiting oxidative stress and apoptosis. Pathology - Research and Practice 2021; 228 doi: 10.1016/j.prp.2021.153656
26
Tae-Won Kim, Dong-Ryung Lee, Bong-Keun Choi, Hwan-Kyu Kang, Ju-Young Jung, Seol-Wa Lim, Seung Hwan Yang, Joo-Won Suh. Hepatoprotective effects of polymethoxyflavones against acute and chronic carbon tetrachloride intoxication. Food and Chemical Toxicology 2016; 91 doi: 10.1016/j.fct.2016.03.004
27
Jie Liang, Jianfeng Yu, Yang Cheng, Yang Wu, Yongliang Li. Electrochemical detection of baicalein based on a three-dimensional micromixer. Journal of Micromechanics and Microengineering 2020; 30(12) doi: 10.1088/1361-6439/abc52d
28
Yu Liu, Pei‑Hao Wen, Xin‑Xue Zhang, Yang Dai, Qiang He. Breviscapine ameliorates CCl4‑induced liver injury in mice through inhibiting inflammatory apoptotic response and ROS generation. International Journal of Molecular Medicine 2018;  doi: 10.3892/ijmm.2018.3651
29
Ali Ahmadi, Zoha Mortazavi, Soghra Mehri, Hossein Hosseinzadeh. Scutellaria baicalensis and its constituents baicalin and baicalein as antidotes or protective agents against chemical toxicities: a comprehensive review. Naunyn-Schmiedeberg's Archives of Pharmacology 2022; 395(11) doi: 10.1007/s00210-022-02258-8
30
Yanni Wang, Xiangxiang Peng, Bingjie Qian, Libo Wang, Jiabing Wang. The integration of metabolites from Forsythia suspensa and gut microbiota ameliorates drug-induced liver injury: network pharmacology and molecular docking studies . Artificial Cells, Nanomedicine, and Biotechnology 2025; 53(1) doi: 10.1080/21691401.2025.2475088
31
Yi-jun Niu, Xin Ai, Xiao-tong Lin, Wei-ming Xu, Su-ya Lao, Zi-chen Tian, Hai-yan Zhu, Wei Zhou, Hai Huang, Xun-long Shi. Baicalein inhibits hepatitis B virus through the coiled coil domain containing protein 88A (CCDC88A)-dependent autophagy pathway. Phytomedicine 2025; 140 doi: 10.1016/j.phymed.2025.156577
32
Yan-Song Ge, Qian-Zhen Zhang, Hui Li, Ge Bai, Zhi-Hui Jiao, Hong-Bin Wang. Hydrogen-rich saline protects against hepatic injury induced by ischemia-reperfusion and laparoscopic hepatectomy in swine. Hepatobiliary & Pancreatic Diseases International 2019; 18(1) doi: 10.1016/j.hbpd.2018.12.001
33
Jiwon Choi, Jayong Chung. Protective effects of baicalein treatment against the development of nonalcoholic steatohepatitis in mice induced by a methionine choline-deficient diet. Journal of Nutrition and Health 2023; 56(6) doi: 10.4163/jnh.2023.56.6.589
34
Biswanath Dinda, Subhajit Dinda, Saikat DasSharma, Rajarshi Banik, Ankita Chakraborty, Manikarna Dinda. Therapeutic potentials of baicalin and its aglycone, baicalein against inflammatory disorders. European Journal of Medicinal Chemistry 2017; 131 doi: 10.1016/j.ejmech.2017.03.004
35
Ting Xiao, Yulong Cui, Heyu Ji, Lulu Yan, Dongjie Pei, Shuangquan Qu. Baicalein attenuates acute liver injury by blocking NLRP3 inflammasome. Biochemical and Biophysical Research Communications 2021; 534 doi: 10.1016/j.bbrc.2020.11.109
36
Sukkum Ngullie Chang, Se Ho Kim, Debasish Kumar Dey, Seon Min Park, Omaima Nasif, Vivek K. Bajpai, Sun Chul Kang, Jintae Lee, Jae Gyu Park. 5-O-Demethylnobiletin Alleviates CCl4-Induced Acute Liver Injury by Equilibrating ROS-Mediated Apoptosis and Autophagy Induction. International Journal of Molecular Sciences 2021; 22(3) doi: 10.3390/ijms22031083
37
Ashutosh Gupta, Abhay K. Pandey. Nutraceuticals and Natural Product Pharmaceuticals. 2019;  doi: 10.1016/B978-0-12-816450-1.00003-9
38
Zhongyue Ren, Yalan Huo, Qimeng Zhang, Shufang Chen, Huihui Lv, Lingling Peng, Hua Wei, Cuixiang Wan. Protective Effect of Lactiplantibacillus plantarum 1201 Combined with Galactooligosaccharide on Carbon Tetrachloride-Induced Acute Liver Injury in Mice. Nutrients 2021; 13(12) doi: 10.3390/nu13124441
39
Wenqing Zhang, Guanru Si, Zhiming Rao, Shuai Zong, Jinglei Li, Xian Zhang, Chuanqiang Gao, Zhou Ping, Ming Ye. Hepatoprotective ability of tetramethylpyrazine produced by Bacillus amyloliquefaciens. Systems Microbiology and Biomanufacturing 2021; 1(2) doi: 10.1007/s43393-020-00018-4
40
Lianyan Jing, Shuai Zong, Jinglei Li, Ming Ye, Maheen Mahwish Surhio, Liu Yang. Potential mechanism of protection effect of exopolysaccharide from Lachnum YM406 and its derivatives on carbon tetrachloride-induced acute liver injury in mice. Journal of Functional Foods 2017; 36 doi: 10.1016/j.jff.2017.06.057
41
Ju Liang, Wenlan Wu, Qiuwei Liu, Shan Chen. Long-circulating nanoliposomes (LCNs) sustained delivery of baicalein (BAI) with desired oral bioavailabilityin vivo. Drug Delivery 2013; 20(8) doi: 10.3109/10717544.2013.834420
42
Manuela G. Neuman, Samuel W. French, Barbara A. French, Helmut K. Seitz, Lawrence B. Cohen, Sebastian Mueller, Natalia A. Osna, Kusum K. Kharbanda, Devanshi Seth, Abraham Bautista, Kyle J. Thompson, Iain H. McKillop, Irina A. Kirpich, Craig J. McClain, Ramon Bataller, Radu M. Nanau, Mihai Voiculescu, Mihai Opris, Hong Shen, Brittany Tillman, Jun Li, Hui Liu, Paul G. Thomes, Murali Ganesan, Steve Malnick. Alcoholic and non-alcoholic steatohepatitis. Experimental and Molecular Pathology 2014; 97(3) doi: 10.1016/j.yexmp.2014.09.005
43
Joseph Kanner. Polyphenols by Generating H2O2, Affect Cell Redox Signaling, Inhibit PTPs and Activate Nrf2 Axis for Adaptation and Cell Surviving: In Vitro, In Vivo and Human Health. Antioxidants 2020; 9(9) doi: 10.3390/antiox9090797
44
Naglaa F. Khedr, Eman G. Khedr. Branched chain amino acids supplementation modulates TGF‐β1/Smad signaling pathway and interleukins in CCl4‐induced liver fibrosis. Fundamental & Clinical Pharmacology 2017; 31(5) doi: 10.1111/fcp.12297
45
Ming Hong, Sha Li, Hor Tan, Ning Wang, Sai-Wah Tsao, Yibin Feng. Current Status of Herbal Medicines in Chronic Liver Disease Therapy: The Biological Effects, Molecular Targets and Future Prospects. International Journal of Molecular Sciences 2015; 16(12) doi: 10.3390/ijms161226126
46
Monica Foghis, Simona Gabriela Bungau, Alexa Florina Bungau, Cosmin Mihai Vesa, Anamaria Lavinia Purza, Alexandra Georgiana Tarce, Delia Mirela Tit, Annamaria Pallag, Tapan Behl, Syed Shams ul Hassan, Andrei-Flavius Radu. Plants-based medicine implication in the evolution of chronic liver diseases. Biomedicine & Pharmacotherapy 2023; 158 doi: 10.1016/j.biopha.2022.114207
47
Swati Sharma, Aishwarya Anand, Nipun Verma, Vishal Sharma, Alka Bhatia, Amol N. Patil, Dibyajyoti Banerjee. Pharmacokinetic Assessment of Isoniazid and Acetylisoniazid in Carbon Tetrachloride-Induced Liver Injury Model in Wistar Rats. Journal of Pharmacy and Bioallied Sciences 2023; 15(3) doi: 10.4103/jpbs.jpbs_320_23
48
Khaled Bellassoued, Houda Hamed, Ferdaws Ghrab, Rim Kallel, Jos Van Pelt, Fatma Makni Ayadi, Abdelfattah Elfeki. Antioxidant and hepatopreventive effects of Cassia angustifolia extract against carbon tetrachloride-induced hepatotoxicity in rats. Archives of Physiology and Biochemistry 2021; 127(6) doi: 10.1080/13813455.2019.1650778
49
Mekky M Abouzied, Shaymaa M Mahmoud, Ahmed Wahid, Amr E Ahmed, Ahmed M Okasha, Hanan A Soliman, Sultan S Al Thagfan, Eman Z Attia. A study of the hepatoprotective effect of Plantago psyllium L. seed extract against Carbon tetrachloride induced hepatic injury in rats. Journal of Applied Biomedicine 2020; 18(2-3) doi: 10.32725/jab.2020.006
50
Asmaa A Ashour, Amal H El-Kamel, Doaa A Abdelmonsif, Hoda M Khalifa, Alyaa A Ramadan. Modified Lipid Nanocapsules for Targeted Tanshinone IIA Delivery in Liver Fibrosis. International Journal of Nanomedicine 2021;  doi: 10.2147/IJN.S331690
51
Rajesh Shukla, Vikas Pandey, Gautam P. Vadnere, Santram Lodhi. Bioactive Food as Dietary Interventions for Arthritis and Related Inflammatory Diseases. 2019;  doi: 10.1016/B978-0-12-813820-5.00018-0
52
Houda Hamed, khaled Bellassoued, Abdelfattah El Feki, Ahmed Gargouri. Evaluation of the hepatoprotective effect of combination between fermented camel milk and Rosmarinus officinalis leaves extract against CCl4 induced liver toxicity in mice. Journal of Food Science and Technology 2019; 56(2) doi: 10.1007/s13197-018-3542-y
53
Nacera Baali, Zahia Belloum, Samiya Baali, Beatrice Chabi, Laurence Pessemesse, Gilles Fouret, Souad Ameddah, Fadila Benayache, Samir Benayache, Christine Feillet-Coudray, Gérard Cabello, Chantal Wrutniak-Cabello. Protective Activity of Total Polyphenols from Genista quadriflora Munby and Teucrium polium geyrii Maire in Acetaminophen-Induced Hepatotoxicity in Rats. Nutrients 2016; 8(4) doi: 10.3390/nu8040193
54
Fu-Rong Wang, Yong-Sheng Jiang. Effect of treatment with baicalein on the intracerebral tumor growth and survival of orthotopic glioma models. Journal of Neuro-Oncology 2015; 124(1) doi: 10.1007/s11060-015-1804-3
55
Amel F.M. Ismail, Asmaa A.M. Salem, Mamdouh M.T. Eassawy. Hepatoprotective effect of grape seed oil against carbon tetrachloride induced oxidative stress in liver of γ-irradiated rat. Journal of Photochemistry and Photobiology B: Biology 2016; 160 doi: 10.1016/j.jphotobiol.2016.03.027
56
MC Üstüner, C Tanrikut, D Üstüner, UK Kolaç, Z Özdemir Köroğlu, D Burukoğlu, E Entok. The effect of baicalein on endoplasmic reticulum stress and autophagy on liver damage. Human & Experimental Toxicology 2021; 40(10) doi: 10.1177/09603271211003634
57
Lingling Tang, Jiali Shao, Hanxue Zheng, Jixuan Chen, Guohua Xia, Huan Yang, Yaya Yang, Yuping Shen. Cleaner production of baicalein by novel high-temperature-little-acid hydrolysis of baicalin. Green Chemistry Letters and Reviews 2024; 17(1) doi: 10.1080/17518253.2024.2319698
58
Johnson Oladele, Taiwo Adewole, Oyedotun Oyeleke, Boyede Olowookere, Oluwaseun Oladele, Adedayo Ademiluyi. Ethanol Extract of Curcuma longa L. Protects Against Carbon Tetrachloride-Induced Oxidative Damage in Renal and Hepatic Tissues of Rats. Journal of Pharmacology and Toxicology 2023; 18(1) doi: 10.3923/jpt.2023.32.41
59
Siwaporn Boonyasuppayakorn, Thanaphon Saelee, Thao Nguyen Thanh Huynh, Rita Hairani, Kowit Hengphasatporn, Naphat Loeanurit, Van Cao, Vipanee Vibulakhaophan, Panattida Siripitakpong, Parveen Kaur, Justin Jang Hann Chu, Chairat Tunghirun, Opas Choksupmanee, Sarin Chimnaronk, Yasuteru Shigeta, Thanyada Rungrotmongkol, Warinthorn Chavasiri. The 8-bromobaicalein inhibited the replication of dengue, and Zika viruses and targeted the dengue polymerase. Scientific Reports 2023; 13(1) doi: 10.1038/s41598-023-32049-x
60
Zheng Liu, Yibo Shi, Chuanjun Hu, Hang Su, Xiaoyuan Yue, Liang Cheng, Wei Shen, Yuanyuan Xia, Li Zhou, Haiquan Yang, Xianzhong Chen. Pharmacological Activities, Biosynthetic Strategies, and Future Prospects: A Comprehensive Review of Baicalein. Journal of Agricultural and Food Chemistry 2026;  doi: 10.1021/acs.jafc.6c10769
61
Enwei Wei, Sixi Zhang, Jinghui Zhai, Sitong Wu, Guangshu Wang. The evaluation of hepatoprotective effects of flavonoids from Scorzonera austriaca Wild against CCl4-induced acute liver injury in vitro and in vivo. Drug and Chemical Toxicology 2022; 45(3) doi: 10.1080/01480545.2020.1815763
62
Su Jin Lee, Su Ji Kim, Hyun-Shik Lee, Oh-Shin Kwon. PKCδ Mediates NF-κB Inflammatory Response and Downregulates SIRT1 Expression in Liver Fibrosis. International Journal of Molecular Sciences 2019; 20(18) doi: 10.3390/ijms20184607
63
Shuai Liang, Xin Deng, Lei Lei, Yao Zheng, Jiao Ai, Linlin Chen, Hui Xiong, Zhinan Mei, Yung-Chi Cheng, Yongshen Ren. The Comparative Study of the Therapeutic Effects and Mechanism of Baicalin, Baicalein, and Their Combination on Ulcerative Colitis Rat. Frontiers in Pharmacology 2019; 10 doi: 10.3389/fphar.2019.01466
64
Hui Luo, Xiao-Dan Lv, Guo-En Wang, Yi-Fang Li, Hiroshi Kurihara, Rong-Rong He. Anti-inflammatory effects of anthocyanins-rich extract from bilberry (Vaccinium myrtillusL.) on croton oil-induced ear edema andPropionibacterium acnesplus LPS-induced liver damage in mice. International Journal of Food Sciences and Nutrition 2014; 65(5) doi: 10.3109/09637486.2014.886184
65
Jiaqi Zhang, Yuchen Sheng, Liang Shi, Zhiyong Zheng, Minwei Chen, Bin Lu, Lili Ji. Quercetin and baicalein suppress monocrotaline-induced hepatic sinusoidal obstruction syndrome in rats. European Journal of Pharmacology 2017; 795 doi: 10.1016/j.ejphar.2016.12.015
66
Xinyi Huang, Xu Chu, Yingying Tian, Yuhan Xue, Lei Zhang, Jing Li, Hu Hou, Ping Dong, Jingfeng Wang. Preventive effect of salmon sperm DNA on acute carbon tetrachloride‐induced liver injury in mice through Nrf2/ARE and mitochondrial apoptosis pathway. Food Science & Nutrition 2023; 11(2) doi: 10.1002/fsn3.3109
67
Istuti Saraswat, Anjana Goel, Jyoti Gupta. Herbal remedies for hepatic diseases: A review of medicinal herbs in the treatment of liver disorders. Chinese Herbal Medicines 2026; 18(2) doi: 10.1016/j.chmed.2026.02.015
68
Cheng-Hsun Yang, Wei-Jen Ting, Cecilia Day, Da-Tong Ju, Yu-Lan Yeh, Li-Chin Chung, Fu-Jenn Tsai, Chang-Hai Tsai, Yuhsin Tsai, Chih-Yang Huang. SHSST Cyclodextrin Complex Prevents the Fibrosis Effect on CCl4-Induced Cirrhotic Cardiomyopathy in Rats through TGF-β Pathway Inhibition Effects. International Journal of Molecular Sciences 2014; 15(5) doi: 10.3390/ijms15058037
69
J Chhimwal, S Sharma, P Kulurkar, V Patial. Crocin attenuates CCl4-induced liver fibrosis via PPAR-γ mediated modulation of inflammation and fibrogenesis in rats. Human & Experimental Toxicology 2020; 39(12) doi: 10.1177/0960327120937048
70
Anding Liu, Liang Huang, Enshuang Guo, Renlong Li, Jiankun Yang, Anyi Li, Yan Yang, Shenpei Liu, Jifa Hu, Xiaojing Jiang, Olaf Dirsch, Uta Dahmen, Jian Sun. Baicalein pretreatment reduces liver ischemia/reperfusion injury via induction of autophagy in rats. Scientific Reports 2016; 6(1) doi: 10.1038/srep25042
71
Xiao Meng, Ya Li, Sha Li, Ren‐You Gan, Hua‐Bin Li. Natural Products for Prevention and Treatment of Chemical‐Induced Liver Injuries. Comprehensive Reviews in Food Science and Food Safety 2018; 17(2) doi: 10.1111/1541-4337.12335
72
Kevin C. Klatt, Elizabeth J. Petviashvili, David D. Moore. LRH-1 induces hepatoprotective nonessential amino acids in response to acute liver injury. Journal of Clinical Investigation 2023; 133(7) doi: 10.1172/JCI168805
73
Farida N. Abdelrazek, Rodayna A. Shalaby, Sally A. Fahim, Reham M. Essam, Shady E. Anis, Yasmin M. Attia, Nevine S. Abd El Malak. Novel fast dissolving freeze dried sublingual baicalin tablets for enhanced hepatoprotective effect: in-vitro characterization, cell viability, and in-vivo evaluation. Pharmaceutical Development and Technology 2024; 29(4) doi: 10.1080/10837450.2024.2341243
74
Anding Liu, Wenjie Wang, Haoshu Fang, Yan Yang, Xiaojing Jiang, Shenpei Liu, Jifa Hu, Qi Hu, Uta Dahmen, Olaf Dirsch. Baicalein protects against polymicrobial sepsis-induced liver injury via inhibition of inflammation and apoptosis in mice. European Journal of Pharmacology 2015; 748 doi: 10.1016/j.ejphar.2014.12.014
75
MENGTING LI, YI-ER QIU, KAIFENG ZHENG. The role of baicalin on carbon tetrachloride induced liver fibrosis. BIOCELL 2022; 46(4) doi: 10.32604/biocell.2022.013432
76
Mohammed Hamid, Yassin Abdulrahim, Dandan Liu, Gang Qian, Alamzeb Khan, Kehe Huang. The Hepatoprotective Effect of Selenium‐Enriched Yeast and Gum Arabic Combination on Carbon Tetrachloride‐Induced Chronic Liver Injury in Rats. Journal of Food Science 2018; 83(2) doi: 10.1111/1750-3841.14030
77
Amr Negm, Amira Afifi El-Neanaey, Abada El Sayed Khadr, Maher Abd El Naby Kamel, Abd El-Hamid Abdo Ismail, Ibrahim El Tantawy El Sayed, Wael Sobhy Darwish, Mabrouk Attia Abd Eldaim, Raghda Sobhy Okaz, Mohamed Hamdy Bahr, Nihal Almuraikhi, Nermine Beshara, Tamer Mohamed Shawky, Ezat A. Mersal. Chlorogenic Acid Ameliorates CCl4-induced Liver Fibrosis by Modulating the PI3K/AKT/mTOR Autophagy Pathway. Anti-Cancer Agents in Medicinal Chemistry 2025; 25(13) doi: 10.2174/0118715206357043250116063202
78
Changwoo Han. Drug-Induced Liver Injury Associated with Scutellaria baicalensis: A Literature Review of Clinical Cases. The Journal of Internal Korean Medicine 2025; 46(6) doi: 10.22246/jikm.2025.46.6.1467
79
Anding Liu, Liang Huang, Hua Fan, Haoshu Fang, Yan Yang, Shenpei Liu, Jifa Hu, Qi Hu, Olaf Dirsch, Uta Dahmen. Baicalein pretreatment protects against liver ischemia/reperfusion injury via inhibition of NF-κB pathway in mice. International Immunopharmacology 2015; 24(1) doi: 10.1016/j.intimp.2014.11.014
80
Ramasamy Selvarani, Hoang Van Michelle Nguyen, Nidheesh Thadathil, Roman F. Wolf, Willard M. Freeman, Christopher D. Wiley, Sathyaseelan S. Deepa, Arlan Richardson. Characterization of novel mouse models to study the role of necroptosis in aging and age-related diseases. GeroScience 2023; 45(6) doi: 10.1007/s11357-023-00955-7
81
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