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For: Woolbright BL, Jaeschke H. Novel insight into mechanisms of cholestatic liver injury. World J Gastroenterol 2012; 18(36): 4985-4993 [PMID: 23049206 DOI: 10.3748/wjg.v18.i36.4985]
URL: https://www.wjgnet.com/1007-9327/full/v18/i36/4985.htm
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Number Citing Articles
1
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Eva Gijbels, Vânia Vilas‐Boas, Pieter Annaert, Tamara Vanhaecke, Lindsey Devisscher, Mathieu Vinken. Robustness testing and optimization of an adverse outcome pathway on cholestatic liver injury. Archives of Toxicology 2020; 94(4) doi: 10.1007/s00204-020-02691-9
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Eva Gijbels, Vânia Vilas-Boas, Neel Deferm, Lindsey Devisscher, Hartmut Jaeschke, Pieter Annaert, Mathieu Vinken. Mechanisms and in vitro models of drug-induced cholestasis. Archives of Toxicology 2019; 93(5) doi: 10.1007/s00204-019-02437-2
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Sanaz Mohajeri, Tedros Bezabeh, Omkar B. Ijare, Scott B. King, Michael Albert Thomas, Gerald Minuk, Jeremy Lipschitz, Iain Kirkpatrick, Allan B. Micflikier, Randy Summers, Ian C.P. Smith. In vivo 1H MRS of human gallbladder bile in understanding the pathophysiology of primary sclerosing cholangitis (PSC): Immune‐mediated disease versus bile acid‐induced injury. NMR in Biomedicine 2019; 32(5) doi: 10.1002/nbm.4065
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Su Jong Yu, Seyeon Bae, Jae Seung Kang, Jung-Hwan Yoon, Eun Ju Cho, Jeong-Hoon Lee, Yoon Jun Kim, Wang Jae Lee, Chung Yong Kim, Hyo-Suk Lee. Hepatoprotective effect of vitamin C on lithocholic acid-induced cholestatic liver injury in Gulo(−/−) mice. European Journal of Pharmacology 2015; 762 doi: 10.1016/j.ejphar.2015.06.008
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Hamid Reza Moheimani, Taghi Amiriani, Ali Mohammad Alizadeh, Yahya Jand, Delaram Shakiba, Parham Sayyah Ensan, Fatemeh Jafarzadeh, Maryam Rajaei, Ayesheh Enayati, Mona Pourabouk, Shahriar Aliazadeh, Amir Hoshang Pourkhani, Zohreh Mazaheri, Mohammad Ali Zeyghami, Ahmadreza Dehpour, Vahid Khori. Preconditioning and anti-apoptotic effects of Metformin and Cyclosporine-A in an isolated bile duct-ligated rat heart. European Journal of Pharmacology 2021; 893 doi: 10.1016/j.ejphar.2020.173807
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Asma Siavashpour, Bahman Khalvati, Negar Azarpira, Hamidreza Mohammadi, Hossein Niknahad, Reza Heidari. Poly (ADP-Ribose) polymerase-1 (PARP-1) overactivity plays a pathogenic role in bile acids-induced nephrotoxicity in cholestatic rats. Toxicology Letters 2020; 330 doi: 10.1016/j.toxlet.2020.05.012
15
Malak Itani, Theodore J. Dubinsky. Physical Chemistry of Bile. Ultrasound Quarterly 2017; 33(3) doi: 10.1097/RUQ.0000000000000287
16
Jennifer K. Truong, Ashley L. Bennett, Caroline Klindt, Ajay C. Donepudi, Sudarshan R. Malla, Kimberly J. Pachura, Alex Zaufel, Tarek Moustafa, Paul A. Dawson, Saul J. Karpen. Ileal bile acid transporter inhibition in Cyp2c70 KO mice ameliorates cholestatic liver injury. Journal of Lipid Research 2022; 63(9) doi: 10.1016/j.jlr.2022.100261
17
Tomoko Takesue, Hiroya Takeuchi, Kazumasa Fukuda, Rieko Nakamura, Tsunehiro Takahashi, Norihito Wada, Hirofumi Kawakubo, Yoshiro Saikawa, Tai Omori, Yuko Kitagawa. Postoperative Hyperbilirubinemia Suggests the Occurrence of Complications After Esophagectomy for Esophageal Cancer. World Journal of Surgery 2015; 39(5) doi: 10.1007/s00268-014-2936-x
18
Annelieke S. de Wit, Romana Nijman, Eugin Destici, Ines Chaves, Gijsbertus T.J. van der Horst. Toxicogenomics-Based Cellular Models. 2014;  doi: 10.1016/B978-0-12-397862-2.00013-9
19
Takeshi Susukida, Shuichi Sekine, Mayuka Nozaki, Mayuko Tokizono, Kousei Ito. Prediction of the Clinical Risk of Drug-Induced Cholestatic Liver Injury Using an In Vitro Sandwich Cultured Hepatocyte Assay. Drug Metabolism and Disposition 2015; 43(11) doi: 10.1124/dmd.115.065425
20
Franziska Durchschein, Elisabeth Krones, Marion J. Pollheimer, Gernot Zollner, Martin Wagner, Jean‐Pierre Raufman, Peter Fickert. Genetic loss of the muscarinic M3 receptor markedly alters bile formation and cholestatic liver injury in mice. Hepatology Research 2018; 48(3) doi: 10.1111/hepr.12928
21
Gulenay Gençosmanoğlu Türkmen, Zehra Vural Yilmaz, Korkut Dağlar, Özgür Kara, Cem Yaşar Sanhal, Aykan Yücel, Dilek Uygur. Low serum vitamin D level is associated with intrahepatic cholestasis of pregnancy. Journal of Obstetrics and Gynaecology Research 2018; 44(9) doi: 10.1111/jog.13693
22
Shi‐Ying Cai, Man Li, James L. Boyer. The Liver. 2020;  doi: 10.1002/9781119436812.ch56
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Kevin M. Tveter, Esther Mezhibovsky, Yue Wu, Diana E. Roopchand. Bile acid metabolism and signaling: Emerging pharmacological targets of dietary polyphenols. Pharmacology & Therapeutics 2023; 248 doi: 10.1016/j.pharmthera.2023.108457
24
Benjamin L Woolbright, Hartmut Jaeschke. Sterile inflammation in acute liver injury: myth or mystery?. Expert Review of Gastroenterology & Hepatology 2015; 9(8) doi: 10.1586/17474124.2015.1060855
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Davor Slijepcevic, Reinout L.P. Roscam Abbing, Claudia D. Fuchs, Lizette C.M. Haazen, Ulrich Beuers, Michael Trauner, Ronald P.J. Oude Elferink, Stan F.J. van de Graaf. Na+‐taurocholate cotransporting polypeptide inhibition has hepatoprotective effects in cholestasis in mice. Hepatology 2018; 68(3) doi: 10.1002/hep.29888
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Xiaodong Qu, Yongquan Shi. Bile reflux and bile acids in the progression of gastric intestinal metaplasia. Chinese Medical Journal 2022; 135(14) doi: 10.1097/CM9.0000000000002290
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Eric Yi-Liang Shen, Mei Ran Abellona U, I. Jane Cox, Simon D. Taylor-Robinson. The Role of Mass Spectrometry in Hepatocellular Carcinoma Biomarker Discovery. Metabolites 2023; 13(10) doi: 10.3390/metabo13101059
28
A.K. Kopec, N. Joshi, J.P. Luyendyk. Role of hemostatic factors in hepatic injury and disease: animal models de‐liver. Journal of Thrombosis and Haemostasis 2016; 14(7) doi: 10.1111/jth.13327
29
Rhian B. Cope. Nutraceuticals in Veterinary Medicine. 2019;  doi: 10.1007/978-3-030-04624-8_51
30
Benjamin L. Woolbright, Hartmut Jaeschke. Experimental Cholestasis Research. Methods in Molecular Biology 2019; 1981 doi: 10.1007/978-1-4939-9420-5_9
31
Hirotsugu Noguchi, Sohsuke Yamada, Atsunori Nabeshima, Xin Guo, Akihide Tanimoto, Ke-Yong Wang, Shohei Kitada, Takashi Tasaki, Tatsuo Takama, Shohei Shimajiri, Hasita Horlad, Yoshihiro Komohara, Hiroto Izumi, Kimitoshi Kohno, Hidenori Ichijo, Yasuyuki Sasaguri. Depletion of Apoptosis Signal-Regulating Kinase 1 Prevents Bile Duct Ligation–Induced Necroinflammation and Subsequent Peribiliary Fibrosis. The American Journal of Pathology 2014; 184(3) doi: 10.1016/j.ajpath.2013.11.030
32
Guoxiang Xie, Xiaoning Wang, Fengjie Huang, Aihua Zhao, Wenlian Chen, Jingyu Yan, Yunjing Zhang, Sha Lei, Kun Ge, Xiaojiao Zheng, Jiajian Liu, Mingming Su, Ping Liu, Wei Jia. Dysregulated hepatic bile acids collaboratively promote liver carcinogenesis. International Journal of Cancer 2016; 139(8) doi: 10.1002/ijc.30219
33
Narendra S. Bhatt, Anilkumar K. Prajapati, Gaurang B. Shah. Exploring animal models and in vitro models for liver diseases: a review. Egyptian Liver Journal 2025; 15(1) doi: 10.1186/s43066-025-00459-3
34
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Milos Mihajlovic, Mathieu Vinken. Mitochondria as the Target of Hepatotoxicity and Drug-Induced Liver Injury: Molecular Mechanisms and Detection Methods. International Journal of Molecular Sciences 2022; 23(6) doi: 10.3390/ijms23063315
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Guoxiang Xie, Yixing Wang, Xiaoning Wang, Aihua Zhao, Tianlu Chen, Yan Ni, Linda Wong, Hua Zhang, Jue Zhang, Chang Liu, Ping Liu, Wei Jia. Profiling of Serum Bile Acids in a Healthy Chinese Population Using UPLC–MS/MS. Journal of Proteome Research 2015; 14(2) doi: 10.1021/pr500920q
37
Min Yang, Anup Ramachandran, Hui-Min Yan, Benjamin L. Woolbright, Bryan L. Copple, Peter Fickert, Michael Trauner, Hartmut Jaeschke. Osteopontin is an initial mediator of inflammation and liver injury during obstructive cholestasis after bile duct ligation in mice. Toxicology Letters 2014; 224(2) doi: 10.1016/j.toxlet.2013.10.030
38
Mitchell R. McGill, Kuo Du, James L. Weemhoff, Hartmut Jaeschke. Critical review of resveratrol in xenobiotic-induced hepatotoxicity. Food and Chemical Toxicology 2015; 86 doi: 10.1016/j.fct.2015.11.003
39
Jung Hyun Park, Bong Jun Kwak, Ho Joong Choi, Ok‐Hee Kim, Ha‐Eun Hong, Sang Chul Lee, Kee‐Hwan Kim, Young Kyoung You, Tae Yun Lee, Joseph Ahn, Say‐June Kim. PGC‐1α is downregulated in a mouse model of obstructive cholestasis but not in a model of liver fibrosis. FEBS Open Bio 2021; 11(1) doi: 10.1002/2211-5463.12961
40
Xiaoyin Ye, Tong Zhang, Han Han. PPARα: A potential therapeutic target of cholestasis. Frontiers in Pharmacology 2022; 13 doi: 10.3389/fphar.2022.916866
41
David Hollenback, Eva Hambruch, Gero Fink, Manfred Birkel, Andreas Schulz, Martin Hornberger, Kathy Liu, Kelly MacLennan Staiger, Helen Desiree Krol, Ulrich Deuschle, Christoph Steeneck, Olaf Kinzel, John T. Liles, Grant Budas, William J. Watkins, Claus Kremoser. Development of Cilofexor, an Intestinally-Biased Farnesoid X Receptor Agonist, for the Treatment of Fatty Liver Disease. The Journal of Pharmacology and Experimental Therapeutics 2024; 389(1) doi: 10.1124/jpet.123.001900
42
Sohsuke Yamada, Xin Guo, Ke‐Yong Wang, Akihide Tanimoto, Yasuyuki Sasaguri. Novel function of histamine signaling via histamine receptors in cholesterol and bile acid metabolism: Histamine H2 receptor protects against nonalcoholic fatty liver disease. Pathology International 2016; 66(7) doi: 10.1111/pin.12423
43
Benjamin L. Woolbright, Wen-Xing Ding, Hartmut Jaeschke. Caspase inhibitors for the treatment of liver disease: friend or foe?. Expert Review of Gastroenterology & Hepatology 2017; 11(5) doi: 10.1080/17474124.2017.1300060
44
Jibiao Li, Benjamin L Woolbright, Wen Zhao, Yifeng Wang, David Matye, Bruno Hagenbuch, Hartmut Jaeschke, Tiangang Li. Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice. Toxicological Sciences 2018; 161(1) doi: 10.1093/toxsci/kfx078
45
Fusheng Xu, Zhiming Yu, Yaru Liu, Ting Du, Leilei Yu, Fengwei Tian, Wei Chen, Qixiao Zhai. A High-Fat, High-Cholesterol Diet Promotes Intestinal Inflammation by Exacerbating Gut Microbiome Dysbiosis and Bile Acid Disorders in Cholecystectomy. Nutrients 2023; 15(17) doi: 10.3390/nu15173829
46
Kenneth Meza Monge, Akshay Pratap, Kevin M. Najarro, Travis M. Walrath, Mercedes Rincon, Rachel H. McMahan, Elizabeth J. Kovacs, Juan-Pablo Idrovo. Targeted Hepatic Methylation-Controlled J Protein Inhibition Mitigates Postsurgical Liver Injury and Neuroinflammation in Aged Mice. Shock 2026; 65(6) doi: 10.1097/SHK.0000000000002684
47
Peter Fickert, Martin Wagner. Biliary bile acids in hepatobiliary injury – What is the link?. Journal of Hepatology 2017; 67(3) doi: 10.1016/j.jhep.2017.04.026
48
Sara Crespo Yanguas, Tereza C. da Silva, Isabel V. A. Pereira, Michaël Maes, Joost Willebrords, Valery I. Shestopalov, Bruna M. Goes, Marina Sayuri Nogueira, Inar Alves de Castro, Guilherme R. Romualdo, Luís F. Barbisan, Eva Gijbels, Mathieu Vinken, Bruno Cogliati. Genetic ablation of pannexin1 counteracts liver fibrosis in a chemical, but not in a surgical mouse model. Archives of Toxicology 2018; 92(8) doi: 10.1007/s00204-018-2255-3
49
Yujun Guo, Min Yang, Shengbo Sun, Zhaohua Zhong, Wenjun Lu, Ze’nan Zhang, Meili Fan, Aodan Zhang, Tingting Zhang, Yang Wu, Zhou Li, Zuwei Liu, Qijun Sun, Zhaozhu Li, Qingbo Cui. FDX1-mediated cuproptosis promotes cholestatic liver injury exacerbated by taurocholic acid-enhanced copper accumulation. Cell Death Discovery 2026; 12(1) doi: 10.1038/s41420-025-02861-7
50
Tea Omanović Kolarić, Vjera Ninčević, Robert Smolić, Martina Smolić, George Y Wu. Mechanisms of Hepatic Cholestatic Drug Injury. Journal of Clinical and Translational Hepatology 2019; 7(X) doi: 10.14218/JCTH.2018.00042
51
Mohammad Mehdi Ommati, Omid Farshad, Negar Azarpira, Marzieh Shafaghat, Hossein Niknahad, Reza Heidari. Betaine alleviates cholestasis-associated renal injury by mitigating oxidative stress and enhancing mitochondrial function. Biologia 2021; 76(1) doi: 10.2478/s11756-020-00576-x
52
Yuan-Fu Lu, Xiao-Li Wan, Yasha Xu, Jie Liu. Repeated Oral Administration of Oleanolic Acid Produces Cholestatic Liver Injury in Mice. Molecules 2013; 18(3) doi: 10.3390/molecules18033060
53
Carol J. Soroka, James L. Boyer. Biosynthesis and trafficking of the bile salt export pump, BSEP: Therapeutic implications of BSEP mutations. Molecular Aspects of Medicine 2014; 37 doi: 10.1016/j.mam.2013.05.001
54
Stephanie K. Meyer, Philip M.E. Probert, Anne F. Lakey, Andrew R. Axon, Alistair C. Leitch, Faith M. Williams, Paul A. Jowsey, Peter G. Blain, George E.N. Kass, Matthew C. Wright. Hepatic effects of tartrazine (E 102) after systemic exposure are independent of oestrogen receptor interactions in the mouse. Toxicology Letters 2017; 273 doi: 10.1016/j.toxlet.2017.03.024
55
Suresh Vatakuti, Jeroen L. A. Pennings, Emilia Gore, Peter Olinga, Geny M. M. Groothuis. Classification of Cholestatic and Necrotic Hepatotoxicants Using Transcriptomics on Human Precision-Cut Liver Slices. Chemical Research in Toxicology 2016; 29(3) doi: 10.1021/acs.chemrestox.5b00491
56
Shi-Ying Cai, Maoxu Ge, Albert Mennone, Rafaz Hoque, Xinshou Ouyang, James L. Boyer. Inflammasome Is Activated in the Liver of Cholestatic Patients and Aggravates Hepatic Injury in Bile Duct–Ligated Mouse. Cellular and Molecular Gastroenterology and Hepatology 2020; 9(4) doi: 10.1016/j.jcmgh.2019.12.008
57
Sebahattin Celik, Hakan Golbasi, Selim Gulucu, Mehmet Guclu, Canan Soyer Caliskan, Samettin Celik, Yasam Kemal Akpak, Ceren Golbasi. Role of Vitamin B12 and Vitamin D levels in intrahepatic cholestasis of pregnancy and correlation with total bile acid. Journal of Obstetrics and Gynaecology 2022; 42(6) doi: 10.1080/01443615.2022.2042797
58
Jorge L Trujillo-Ochoa, Karla F Corral-Jara, Griselda Escobedo-Meléndez, Mauricio Realpe, Arturo Panduro, Sonia Roman, Nora A Fierro. T-helper 17-related cytokines and IgE antibodies during hepatitis A virus infection in children. Memórias do Instituto Oswaldo Cruz 2015; 110(2) doi: 10.1590/0074-02760140309
59
Lauren N Bell, Jacob Wulff, Megan Comerford, Raj Vuppalanchi, Naga Chalasani. Serum metabolic signatures of primary biliary cirrhosis and primary sclerosing cholangitis. Liver International 2015; 35(1) doi: 10.1111/liv.12680
60
Máté Katona, Péter Hegyi, Balázs Kui, Zsolt Balla, Zoltán Rakonczay, Zsolt Rázga, László Tiszlavicz, József Maléth, Viktória Venglovecz. A novel, protective role of ursodeoxycholate in bile-induced pancreatic ductal injury. American Journal of Physiology-Gastrointestinal and Liver Physiology 2016; 310(3) doi: 10.1152/ajpgi.00317.2015
61
Stephanie Rattay, Dirk Graf, Andreas Kislat, Bernhard Homey, Diran Herebian, Dieter Häussinger, Hartmut Hengel, Albert Zimmermann, Anna-Kathrin Schupp, Michael Nevels. Anti-inflammatory consequences of bile acid accumulation in virus-infected bile duct ligated mice. PLOS ONE 2018; 13(6) doi: 10.1371/journal.pone.0199863
62
Mengke Yuan, Zilong Sun, Ram Kumar Manthari, Yangfei Zhao, Qiang Guo, Kaidong Yang, Jundong Wang. Arsenic-induced autophagy regulates apoptosis in AML-12 cells. Toxicology in Vitro 2021; 72 doi: 10.1016/j.tiv.2020.105074
63
Rujian He, Hongjie Zhong, Chang He, Hailing Li, Zhanxiang Wang, Jing Zheng, Guiying Li, Taicheng An. Individual and mixture effects of BTEX occupational exposure with hematologic and hepatic profiles in petrochemical workers and the metabolic mechanism. Journal of Environmental Sciences 2025; 154 doi: 10.1016/j.jes.2024.06.021
64
Mathieu Vinken. The adverse outcome pathway concept: A pragmatic tool in toxicology. Toxicology 2013; 312 doi: 10.1016/j.tox.2013.08.011
65
Mathieu Vinken. In Silico Methods for Predicting Drug Toxicity. Methods in Molecular Biology 2016; 1425 doi: 10.1007/978-1-4939-3609-0_14
66
Tiangang Li, John Y. L. Chiang. Cellular Injury in Liver Diseases. 2017;  doi: 10.1007/978-3-319-53774-0_7
67
Katrin Panzitt, Peter Fickert, Martin Wagner. Regulation of autophagy by bile acids and in cholestasis - CholestoPHAGY or CholeSTOPagy. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2021; 1867(2) doi: 10.1016/j.bbadis.2020.166017
68
Göksun İpek, Atakan Tanaçan, Ayça Peker, Zahid Ağaoğlu, Özgür Kara, Dilek Şahin. Systemic Inflammation Response Index as a diagnostic and prognostic predictor of intrahepatic cholestasis of pregnancy: A case–control study from a tertiary center. International Journal of Gynecology & Obstetrics 2024; 165(2) doi: 10.1002/ijgo.15216
69
Benjamin L. Woolbright, Hartmut Jaeschke. Inflammation and Cell Death During Cholestasis: The Evolving Role of Bile Acids. Gene Expression 2019; 19(3) doi: 10.3727/105221619X15614873062730
70
Spencer P Larson, Oormila Kovilam, Devendra K Agrawal. Immunological basis in the pathogenesis of intrahepatic cholestasis of pregnancy. Expert Review of Clinical Immunology 2016; 12(1) doi: 10.1586/1744666X.2016.1101344
71
Xiao Yang, Hangfei Liang, Xuan Li, Jianing Tian, Shicheng Fan, Min Huang, Jianbo Wan, Zhong Zuo, Haibiao Guo, Huichang Bi. Schisandrol B protects against lithocholic acid-induced cholestatic liver injury in mice through mitochondrial biogenesis. Chinese Medicine 2026; 21(1) doi: 10.1186/s13020-026-01342-y
72
Hartmut Jaeschke, Anup Ramachandran. Acetaminophen Toxicity. 2025;  doi: 10.1016/B978-0-443-15877-3.00009-0
73
Ke Liu, Jiong Yan, Madhav Sachar, Xinju Zhang, Ming Guan, Wen Xie, Xiaochao Ma. A metabolomic perspective of griseofulvin-induced liver injury in mice. Biochemical Pharmacology 2015; 98(3) doi: 10.1016/j.bcp.2015.09.002
74
Orkun Cetin, Erbil Karaman, Harun Arslan, Ibrahim Akbudak, Recep Yildizhan, Ali Kolusari. Maternal liver elasticity determined by acoustic radiation force impulse elastosonography in intrahepatic cholestasis of pregnancy. Journal of Medical Ultrasonics 2017; 44(3) doi: 10.1007/s10396-016-0768-z
75
Qian Wang, Guo-Chao Song, Feng-Yi Weng, Bin Zou, Jing-Yi Jin, Dong-Ming Yan, Bo Tan, Jing Zhao, Yue Li, Fu-Rong Qiu. Hepatoprotective Effects of Glycyrrhetinic Acid on Lithocholic Acid-Induced Cholestatic Liver Injury Through Choleretic and Anti-Inflammatory Mechanisms. Frontiers in Pharmacology 2022; 13 doi: 10.3389/fphar.2022.881231
76
Shinji Ito, Junko Satoh, Tsutomu Matsubara, Yatrik M Shah, Sung-hoon Ahn, Cherie R Anderson, Weiwei Shan, Jeffrey M Peters, Frank J Gonzalez. Cholestasis induces reversible accumulation of periplakin in mouse liver. BMC Gastroenterology 2013; 13(1) doi: 10.1186/1471-230X-13-116
77
Mitchell R. McGill, Benjamin L. Woolbright, James L. Weemhoff, Hartmut Jaeschke. Biomarkers in Liver Disease. Biomarkers in Disease: Methods, Discoveries and Applications 2017;  doi: 10.1007/978-94-007-7675-3_5
78
Lina Luo, Jiri Aubrecht, Dingzhou Li, Roscoe L. Warner, Kent J. Johnson, Julia Kenny, Jennifer L. Colangelo, Patricia Aspichueta. Assessment of serum bile acid profiles as biomarkers of liver injury and liver disease in humans. PLOS ONE 2018; 13(3) doi: 10.1371/journal.pone.0193824
79
Rohan Magdum, Sanman Kolhe, Pramod Kolsure, Umesh Chandra Dash, Sriram Padmanabhan. Alleviation of favipiravir-induced hepatotoxicity using hepatoprotective herbal extracts in wistar rats. Natural Product Research 2025; 39(23) doi: 10.1080/14786419.2024.2384084
80
Tom De Bruyn, Sagnik Chatterjee, Sarinj Fattah, Janneke Keemink, Johan Nicolaï, Patrick Augustijns, Pieter Annaert. Sandwich-cultured hepatocytes: utility forin vitroexploration of hepatobiliary drug disposition and drug-induced hepatotoxicity. Expert Opinion on Drug Metabolism & Toxicology 2013; 9(5) doi: 10.1517/17425255.2013.773973
81
Charles Oluwaseun Adetunji, Muhammad Akram, Andrew G. Mtewa, Jaison Jeevanandam, Chukwuebuka Egbuna, Alloysius Chibuike Ogodo, Ajay Kumar Gautam, Ashutosh Gupta, Peculiar Feenna Onyekere, Genevieve D. Tupas, Shahira M. Ezzat, Sunil Pareek, Habibu Tijjani, Nadia Sharif, Devaraj Ezhilarasan, Sadia Hassan, Narashans Alok Sagar, Abeer M. El Sayed, Mohammad Mehdizadeh, Merve Keskin, Chioma Obianuju Peculiar-Onyekere, Angelo Mark P. Walag, Priyanka Dhar, Abolanle A.A. Kayode, Ghulam Mohiudin, Khalil Ahmad, Shashank Kumar, Rida Zainab, Muhammad Kamran Khan, Muhammad Adil Farooq, Lisbeth Vallecilla-Yepez, Yusuf Abubakar, Ahmed Olatunde. Preparation of Phytopharmaceuticals for the Management of Disorders. 2021;  doi: 10.1016/B978-0-12-820284-5.00015-0
82
James M. Crawford, Paulette Bioulac-Sage, Prodromos Hytiroglou. MacSween's Pathology of the Liver. 2024;  doi: 10.1016/B978-0-7020-8228-3.00001-6
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Theresa Maria Holtmann, Maria Eugenia Inzaugarat, Jana Knorr, Lukas Geisler, Marten Schulz, Veerle Bieghs, Mick Frissen, Ariel E. Feldstein, Frank Tacke, Christian Trautwein, Alexander Wree. Bile Acids Activate NLRP3 Inflammasome, Promoting Murine Liver Inflammation or Fibrosis in a Cell Type-Specific Manner. Cells 2021; 10(10) doi: 10.3390/cells10102618
84
Serge Erlinger. Bile acids in cholestasis: Bad for the liver, not so good for the kidney. Clinics and Research in Hepatology and Gastroenterology 2014; 38(4) doi: 10.1016/j.clinre.2014.03.003
85
Christoph Sponholz, Katja Matthes, Dina Rupp, Wolf Backaus, Sebastian Klammt, Diana Karailieva, Astrid Bauschke, Utz Settmacher, Matthias Kohl, Mark G. Clemens, Steffen Mitzner, Michael Bauer, Andreas Kortgen. Molecular adsorbent recirculating system and single-pass albumin dialysis in liver failure – a prospective, randomised crossover study. Critical Care 2016; 20(1) doi: 10.1186/s13054-015-1159-3
86
Christopher Brewer, Taosheng Chen. Hepatotoxicity of Herbal Supplements Mediated by Modulation of Cytochrome P450. International Journal of Molecular Sciences 2017; 18(11) doi: 10.3390/ijms18112353
87
Matthias Cuykx, Charlie Beirnaert, Robim M. Rodrigues, Kris Laukens, Tamara Vanhaecke, Adrian Covaci. Untargeted liquid chromatography-mass spectrometry metabolomics to assess drug-induced cholestatic features in HepaRG® cells. Toxicology and Applied Pharmacology 2019; 379 doi: 10.1016/j.taap.2019.114666
88
Benjamin L. Woolbright, Kenneth Dorko, Daniel J. Antoine, Joanna I. Clarke, Parviz Gholami, Feng Li, Sean C. Kumer, Timothy M. Schmitt, Jameson Forster, Fang Fan, Rosalind E. Jenkins, B. Kevin Park, Bruno Hagenbuch, Mojtaba Olyaee, Hartmut Jaeschke. Bile acid-induced necrosis in primary human hepatocytes and in patients with obstructive cholestasis. Toxicology and Applied Pharmacology 2015; 283(3) doi: 10.1016/j.taap.2015.01.015
89
James M. Crawford, Paulette Bioulac-Sage, Prodromos Hytiroglou. Macsween's Pathology of the Liver. 2018;  doi: 10.1016/B978-0-7020-6697-9.00001-7
90
Tânia Sousa, Rui E. Castro, Ana Coutinho, Cecília M. P. Rodrigues, Manuel Prieto, Fábio Fernandes. Experimental Cholestasis Research. Methods in Molecular Biology 2019; 1981 doi: 10.1007/978-1-4939-9420-5_7
91
Dan Huang, Minli Xiong, Xianjun Xu, Xiaowan Wu, Jingxian Xu, Xiaobo Cai, Lungen Lu, Hui Zhou. Bile acids elevated by high-fat feeding induce endoplasmic reticulum stress in intestinal stem cells and contribute to mucosal barrier damage. Biochemical and Biophysical Research Communications 2020; 529(2) doi: 10.1016/j.bbrc.2020.05.226
92
Fan-bo Yang, Xue-shan Li, Kai Song, Ling Wang, Rui-juan Ma, Kang-le Lu, Chun-xiao Zhang. Accumulation of hydrophobic bile acids mediates chronic heat stress-induced liver-gut axis injury in spotted seabass (Lateolabrax maculatus). Aquaculture 2026; 625 doi: 10.1016/j.aquaculture.2026.744302
93
Savneet Kaur, Dinesh M. Tripathi. A Comprehensive Guide to Rodent Models of Liver Diseases. 2025;  doi: 10.1016/B978-0-323-99478-1.00008-0
94
Hayato Nakagawa, Nobumi Suzuki, Yoshihiro Hirata, Yohko Hikiba, Yoku Hayakawa, Hiroto Kinoshita, Sozaburo Ihara, Koji Uchino, Yuji Nishikawa, Hideaki Ijichi, Motoyuki Otsuka, Junichi Arita, Yoshihiro Sakamoto, Kiyoshi Hasegawa, Norihiro Kokudo, Keisuke Tateishi, Kazuhiko Koike. Biliary epithelial injury-induced regenerative response by IL-33 promotes cholangiocarcinogenesis from peribiliary glands. Proceedings of the National Academy of Sciences 2017; 114(19) doi: 10.1073/pnas.1619416114
95
Courtney B. Ferrebee, Jianing Li, Jamie Haywood, Kimberly Pachura, Brian S. Robinson, Benjamin H. Hinrichs, Rheinallt M. Jones, Anuradha Rao, Paul A. Dawson. Organic Solute Transporter α-β Protects Ileal Enterocytes From Bile Acid–Induced Injury. Cellular and Molecular Gastroenterology and Hepatology 2018; 5(4) doi: 10.1016/j.jcmgh.2018.01.006
96
Bastian Kister, Alina Viehof, Ulrike Rolle-Kampczyk, Annika Schwentker, Nicole Simone Treichel, Susan A.V. Jennings, Theresa H. Wirtz, Lars M. Blank, Mathias W. Hornef, Martin von Bergen, Thomas Clavel, Lars Kuepfer. A physiologically based model of bile acid metabolism in mice. iScience 2023; 26(10) doi: 10.1016/j.isci.2023.107922
97
Tim van Zutphen, Jolita Ciapaite, Vincent W. Bloks, Cameron Ackereley, Albert Gerding, Angelika Jurdzinski, Roberta Allgayer de Moraes, Ling Zhang, Justina C. Wolters, Rainer Bischoff, Ronald J. Wanders, Sander M. Houten, Dana Bronte-Tinkew, Tatiana Shatseva, Gary F. Lewis, Albert K. Groen, Dirk-Jan Reijngoud, Barbara M. Bakker, Johan W. Jonker, Peter K. Kim, Robert H.J. Bandsma. Malnutrition-associated liver steatosis and ATP depletion is caused by peroxisomal and mitochondrial dysfunction. Journal of Hepatology 2016; 65(6) doi: 10.1016/j.jhep.2016.05.046
98
Xuebin Gao, Xiaozhuan Lin, Yan Xin, Xuan Zhu, Xiang Li, Ming Chen, Zhigang Huang, Honghui Guo. Dietary cholesterol drives the development of nonalcoholic steatohepatitis by altering gut microbiota mediated bile acid metabolism in high-fat diet fed mice. The Journal of Nutritional Biochemistry 2023; 117 doi: 10.1016/j.jnutbio.2023.109347
99
Anna C. Croce, Giovanni Bottiroli, Laura G. Di Pasqua, Clarissa Berardo, Veronica Siciliano, Vittoria Rizzo, Mariapia Vairetti, Andrea Ferrigno. Serum and Hepatic Autofluorescence as a Real-Time Diagnostic Tool for Early Cholestasis Assessment. International Journal of Molecular Sciences 2018; 19(9) doi: 10.3390/ijms19092634
100
Oriol Juanola, Mohsin Hassan, Pavitra Kumar, Bahtiyar Yilmaz, Irene Keller, Cédric Simillion, Cornelius Engelmann, Frank Tacke, Jean-François Dufour, Andrea De Gottardi, Sheida Moghadamrad. Intestinal microbiota drives cholestasis-induced specific hepatic gene expression patterns. Gut Microbes 2021; 13(1) doi: 10.1080/19490976.2021.1911534
101
Ci Zhu, Thierry Claudel, Michael Trauner. Liver Immunology. 2020;  doi: 10.1007/978-3-030-51709-0_7
102
Mathieu Vinken. In vitro prediction of drug-induced cholestatic liver injury: a challenge for the toxicologist. Archives of Toxicology 2018; 92(5) doi: 10.1007/s00204-018-2201-4
103
Zheng Zhou, Kang Yong, Zhengzhong Luo, Zhenlong Du, Tao Zhou, Xiaoping Li, Xueping Yao, Liuhong Shen, Shumin Yu, Yixin Huang, Suizhong Cao. The Positive Regulatory Effect of DBT on Lipid Metabolism in Postpartum Dairy Cows. Metabolites 2025; 15(1) doi: 10.3390/metabo15010058
104
Benjamin L. Woolbright, Mitchell R. McGill, Vincent S. Staggs, Robert D. Winefield, Parviz Gholami, Mojtaba Olyaee, Matthew R. Sharpe, Steven C. Curry, William M. Lee, Hartmut Jaeschke. Glycodeoxycholic Acid Levels as Prognostic Biomarker in Acetaminophen-Induced Acute Liver Failure Patients. Toxicological Sciences 2014; 142(2) doi: 10.1093/toxsci/kfu195
105
Giovanni Tarantino, Vincenzo Citro, Domenico Capone, Giuseppe Gaudiano, Gaia Sinatti, Silvano Junior Santini, Clara Balsano. Copper concentrations are prevalently associated with antithrombin III, but also with prothrombin time and fibrinogen in patients with liver cirrhosis: A cross-sectional retrospective study. Journal of Trace Elements in Medicine and Biology 2021; 68 doi: 10.1016/j.jtemb.2021.126802
106
V. Šmíd, T. Petr, K. Váňová, J. Jašprová, J. Šuk, L. Vítek, F. Šmíd, Lucie Muchová. Changes in Liver Ganglioside Metabolism in Obstructive Cholestasis – the Role of Oxidative Stress. Folia Biologica 2016; 62(4) doi: 10.14712/fb2016062040148
107
Sara Ibrahim, Rania Dayoub, Sabrina Krautbauer, Gerhard Liebisch, Anja Kathrin Wege, Michael Melter, Thomas S. Weiss. Bile acid-induced apoptosis and bile acid synthesis are reduced by over-expression of Augmenter of Liver Regeneration (ALR) in a STAT3-dependent mechanism. Experimental Cell Research 2019; 374(1) doi: 10.1016/j.yexcr.2018.11.023
108
Mengjun Luo, Li Wang, Haibo Yao, Yizhou Wen, Dengcheng Cao, Wei Shen, Chenggui Liu. Diagnostic and prognostic value of blood inflammation and biochemical indicators for intrahepatic cholestasis of pregnancy in Chinese pregnant women. Scientific Reports 2022; 12(1) doi: 10.1038/s41598-022-22199-9
109
Haoyu Xue, Su Fang, Min Zheng, Jiasheng Wu, Hongyu Li, Mengdie Zhang, Yuanyuan Li, Tianming Wang, Rong Shi, Yueming Ma. Da-Huang-Xiao-Shi decoction protects against3, 5-diethoxycarbonyl-1,4-dihydroxychollidine-induced chronic cholestasis by upregulating bile acid metabolic enzymes and efflux transporters. Journal of Ethnopharmacology 2021; 269 doi: 10.1016/j.jep.2020.113706
110
Benjamin L. Woolbright, Hartmut Jaeschke. Role of the inflammasome in acetaminophen-induced liver injury and acute liver failure. Journal of Hepatology 2017; 66(4) doi: 10.1016/j.jhep.2016.11.017
111
Eva Gijbels, Lindsey Devisscher, Mathieu Vinken. Testing in vitro tools for the prediction of cholestatic liver injury induced by non-pharmaceutical chemicals. Food and Chemical Toxicology 2021; 152 doi: 10.1016/j.fct.2021.112165
112
Flor P. Castro‐García, Karla F. Corral‐Jara, Griselda Escobedo‐Melendez, Monserrat A. Sandoval‐Hernandez, Yvonne Rosenstein, Sonia Roman, Arturo Panduro, Nora A. Fierro. Conjugated bilirubin affects cytokine profiles in hepatitis A virus infection by modulating function of signal transducer and activator of transcription factors. Immunology 2014; 143(4) doi: 10.1111/imm.12336
113
Giuseppina Palladini, Andrea Ferrigno, Plinio Richelmi, Stefano Perlini, Mariapia Vairetti. Role of matrix metalloproteinases in cholestasis and hepatic ischemia/reperfusion injury: A review. World Journal of Gastroenterology 2015; 21(42): 12114-12124 doi: 10.3748/wjg.v21.i42.12114
114
Fei Xiong, Zhongdaixi Zheng, Lingyu Xiao, Chuhong Su, Junbin Chen, Xiangfu Gu, Jiaqi Tang, Yue Zhao, Huiyu Luo, Longying Zha. Soyasaponin A2 Alleviates Steatohepatitis Possibly through Regulating Bile Acids and Gut Microbiota in the Methionine and Choline‐Deficient (MCD) Diet‐induced Nonalcoholic Steatohepatitis (NASH) Mice. Molecular Nutrition & Food Research 2021; 65(14) doi: 10.1002/mnfr.202100067
115
Sakshi Bhatele, Mahi Mhatre, Muktika Tekade, Nupur Vasdev, Bhakti Pawar, Rakesh Kumar Tekade. Public Health and Toxicology Issues Drug Research, Volume 2. 2024;  doi: 10.1016/B978-0-443-15842-1.00015-6
116
Eva Gijbels, Mathieu Vinken. An Update on Adverse Outcome Pathways Leading to Liver Injury. Applied In Vitro Toxicology 2017; 3(4) doi: 10.1089/aivt.2017.0027
117
Kamila Bechynska, Nikola Daskova, Nikola Vrzackova, Karel Harant, Marie Heczková, Katerina Podzimkova, Miriam Bratova, Helena Dankova, Zuzana Berkova, Vit Kosek, Jaroslav Zelenka, Jana Hajslova, Radislav Sedlacek, Jiri Suttnar, Alzbeta Hlavackova, Lenka Bartonova, Monika Cahova. The effect of ω-3 polyunsaturated fatty acids on the liver lipidome, proteome and bile acid profile: parenteral versus enteral administration. Scientific Reports 2019; 9(1) doi: 10.1038/s41598-019-54225-8
118
Jessica Silva, Melissa Magenta, Giovanni Sisti, Lisa Serventi, Kecia Gaither. Association Between Complete Blood Count Components and Intrahepatic Cholestasis of Pregnancy . Cureus 2020;  doi: 10.7759/cureus.12381
119
Yanting Xu, Feng Zhang, Ziliang Ke, Yiken Lin, Yang Zhang, Yun Liu, Yifan Zhang, Jun Xu, Yulan Liu. HFD Exacerbates Hepatic Lipid Metabolism Disorders After Cholecystectomy by Regulating the Bile Acid and Neutrophil Recruitment. Liver International 2025; 45(7) doi: 10.1111/liv.70130
120
Man Li, Albert Mennone, Carol J. Soroka, Lee R. Hagey, Xinshou Ouyang, Edward J. Weinman, James L. Boyer. Na+/H+ exchanger regulatory factor 1 knockout mice have an attenuated hepatic inflammatory response and are protected from cholestatic liver injury. Hepatology 2015; 62(4) doi: 10.1002/hep.27956
121
Dong Xiang, Jinyu Yang, Yanjiao Xu, Lulu Lan, Guodong Li, Chengliang Zhang, Dong Liu. Estrogen cholestasis induces gut and liver injury in rats involving in activating PI3K/Akt and MAPK signaling pathways. Life Sciences 2021; 276 doi: 10.1016/j.lfs.2021.119367
122
Hereward J. Wimborne, Kenji Takemoto, Patrick M. Woster, Don C. Rockey, John J. Lemasters, Zhi Zhong. Aldehyde dehydrogenase-2 activation by Alda-1 decreases necrosis and fibrosis after bile duct ligation in mice. Free Radical Biology and Medicine 2019; 145 doi: 10.1016/j.freeradbiomed.2019.09.026
123
Mathieu Vinken, Brigitte Landesmann, Marina Goumenou, Stefanie Vinken, Imran Shah, Hartmut Jaeschke, Catherine Willett, Maurice Whelan, Vera Rogiers. Development of an Adverse Outcome Pathway From Drug-Mediated Bile Salt Export Pump Inhibition to Cholestatic Liver Injury. Toxicological Sciences 2013; 136(1) doi: 10.1093/toxsci/kft177
124
Benjamin L. Woolbright, Hartmut Jaeschke. Cytochrome P450 Function and Pharmacological Roles in Inflammation and Cancer. Advances in Pharmacology 2015; 74 doi: 10.1016/bs.apha.2015.04.001
125
Ahmad Sharanek, Audrey Burban, Nadia Ciriaci, André Guillouzo. Pro-inflammatory cytokines enhance dilatation of bile canaliculi caused by cholestatic antibiotics. Toxicology in Vitro 2019; 58 doi: 10.1016/j.tiv.2019.03.015
126
Jiao Zhao, Qingcheng Yang, Zhiyuan Liu, Pengfei Xu, Lei Tian, Jun Yan, Kang Li, Bencheng Lin, Liping Bian, Zhuge Xi, Xiaohua Liu. The impact of subchronic ozone exposure on serum metabolome and the mechanisms of abnormal bile acid and arachidonic acid metabolisms in the liver. Ecotoxicology and Environmental Safety 2023; 252 doi: 10.1016/j.ecoenv.2023.114573
127
J J Sutherland, Y W Webster, J A Willy, G H Searfoss, K M Goldstein, A R Irizarry, D G Hall, J L Stevens. Toxicogenomic module associations with pathogenesis: a network-based approach to understanding drug toxicity. The Pharmacogenomics Journal 2018; 18(3) doi: 10.1038/tpj.2017.17
128
FanCheng Meng, Wei Zong, XiaoDong Wei, YunYi Tao, GuoWei Wang, ZhiHua Liao, Min Chen. Dolomiaea souliei ethyl acetate extract protected against α-naphthylisothiocyanate-induced acute intrahepatic cholestasis through regulation of farnesoid x receptor-mediated bile acid metabolism. Phytomedicine 2021; 87 doi: 10.1016/j.phymed.2021.153588
129
Dan Shan, Ruihong Dong, Yayi Hu. Current understanding of autophagy in intrahepatic cholestasis of pregnancy. Placenta 2021; 115 doi: 10.1016/j.placenta.2021.09.014
130
Mathieu Vinken. Adverse Outcome Pathways and Drug-Induced Liver Injury Testing. Chemical Research in Toxicology 2015; 28(7) doi: 10.1021/acs.chemrestox.5b00208
131
Jing Zhang, Huiling Li, Jianyi Dong, Nan Zhang, Yang Liu, Xiaoqin Luo, Jun Chen, Jingyu Wang, Aiguo Wang. Omics-Based Identification of Shared and Gender Disparity Routes in Hras12V-Induced Hepatocarcinogenesis: An Important Role for Dlk1-Dio3 Genomic Imprinting Region. Frontiers in Genetics 2021; 12 doi: 10.3389/fgene.2021.620594
132
Akinori Takemura, Simin Gong, Shuichi Sekine, Kousei Ito. Inhibition of biliary network reconstruction by benzbromarone delays recovery from pre-existing liver injury. Toxicology 2019; 423 doi: 10.1016/j.tox.2019.05.004
133
Ki-Hyun Kim, Chih-Chiun Chen, Gianfranco Alpini, Lester F. Lau. CCN1 induces hepatic ductular reaction through integrin αvβ5–mediated activation of NF-κB. Journal of Clinical Investigation 2015; 125(5) doi: 10.1172/JCI79327
134
Xiaolin Wu, Qiao Yu, Yuzhao Hou, Xuemei Zhang, Simon Sani Ocholi, Liming Wang, Ziping Yan, Jie Li, Lifeng Han. Emodin-8-O-β-D-glucopyranoside alleviates cholestasis by maintaining intestinal homeostasis and regulating lipids and bile acids metabolism in mice. Journal of Pharmaceutical and Biomedical Analysis 2025; 258 doi: 10.1016/j.jpba.2025.116734
135
Juan Hao, Xiaoyu Shen, Xiaohong Shao, Chunling Zhu, Kan Lu, Yi Xu, Yiyue Chen, Jibo Liu, Yaqin Ding, Xin Xie, Jian Wu, Quanjun Yang. Honokiol attenuates ductular reaction, regulates of bile acids metabolism, and inhibits inflammatory response in murine cholestatic liver injury model. Arabian Journal of Chemistry 2023; 16(8) doi: 10.1016/j.arabjc.2023.104968
136
B.L. Woolbright, C.D. Williams, M.R. McGill, H. Jaeschke. Reference Module in Biomedical Sciences. 2014;  doi: 10.1016/B978-0-12-801238-3.00205-1
137
Fan Yang, Xiaowen Tang, Lili Ding, Yue zhou, Qiaoling Yang, Junting Gong, Guangyun Wang, Zhengtao Wang, Li Yang. Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation. Scientific Reports 2016; 6(1) doi: 10.1038/srep33052
138
Benjamin L. Woolbright, Mitchell R. McGill, Huimin Yan, Hartmut Jaeschke. Bile Acid‐Induced Toxicity in HepaRG Cells Recapitulates the Response in Primary Human Hepatocytes. Basic & Clinical Pharmacology & Toxicology 2016; 118(2) doi: 10.1111/bcpt.12449
139
Qiang Guo, Maolin Wang, Kai Zhong, Jialong Li, Tiemin Jiang, Bo Ran, Paizula Shalayiadang, Ruiqing Zhang, Talaiti Tuergan, Tuerganaili Aji, Yingmei Shao. Application of hepatic lobe hyperplasia techniques in the treatment of advanced hepatic alveolar echinococcosis: a single-centre experience. BMC Surgery 2022; 22(1) doi: 10.1186/s12893-022-01864-w
140
Heyun Zhu, Kaishun Bi, Fei Han, Jiao Guan, Zheng Tang, Kelin Chen, Longshan Zhao, Qing Li, Ran Yin, Xiaohong Hou. Simultaneous determination of two iridoid glycosides, two anthraquinones and four flavonoid glycosides of Zhi-Zi-Da-Huang decoction in rat plasma by UFLC-MS/MS: Application to a comparative pharmacokinetic study in normal and cholestatic liver injury rats. Journal of Chromatography B 2014; 960 doi: 10.1016/j.jchromb.2014.04.031
141
Valeria Mariotti, Massimiliano Cadamuro, Carlo Spirli, Romina Fiorotto, Mario Strazzabosco, Luca Fabris. Animal models of cholestasis: An update on inflammatory cholangiopathies. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2019; 1865(5) doi: 10.1016/j.bbadis.2018.07.025
142
Mitchell R. McGill, Benjamin L. Woolbright, James L. Weemhoff, Hartmut Jaeschke. Biomarkers in Liver Disease. Biomarkers in Disease: Methods, Discoveries and Applications 2016;  doi: 10.1007/978-94-007-7742-2_5-1
143
Zhong Xian, Jingzhuo Tian, Lianmei Wang, Yushi Zhang, Jiayin Han, Nuo Deng, Suyan Liu, Yong Zhao, Chunyin Li, Yan Yi, Dunfang Wang, Jing Meng, Chen Pan, Aihua Liang, Fatma M. El-Demerdash. Effects of Rhein on Bile Acid Homeostasis in Rats. BioMed Research International 2020; 2020(1) doi: 10.1155/2020/8827955
144
Xing Wen, Xu Feng, Yao Kang, Long Xu. Application Progress of Gd-EOB-DTPA-Enhanced MRI T1 Mapping in Hepatic Diffuse Diseases. Current Medical Imaging Reviews 2022; 18(12) doi: 10.2174/1573405617666211130153450
145
A.J. Demetris, C.O.C. Bellamy, C.R. Gandhi, S. Prost, Y. Nakanuma, D.B. Stolz. Functional Immune Anatomy of the Liver—As an Allograft. American Journal of Transplantation 2016; 16(6) doi: 10.1111/ajt.13749
146
Shi-Ying Cai, Dongke Yu, Carol J. Soroka, Jing Wang, James L. Boyer. Hepatic NFAT signaling regulates the expression of inflammatory cytokines in cholestasis. Journal of Hepatology 2021; 74(3) doi: 10.1016/j.jhep.2020.09.035
147
Benjamin L. Woolbright, Feng Li, Yuchao Xie, Anwar Farhood, Peter Fickert, Michael Trauner, Hartmut Jaeschke. Lithocholic acid feeding results in direct hepato-toxicity independent of neutrophil function in mice. Toxicology Letters 2014; 228(1) doi: 10.1016/j.toxlet.2014.04.001
148
Elias Kouroumalis, Argryro Voumvouraki, Aikaterini Augoustaki, Dimitrios N Samonakis. Autophagy in liver diseases. World Journal of Hepatology 2021; 13(1): 6-65 doi: 10.4254/wjh.v13.i1.6
149
Ayse Kirbas, Ebru Biberoglu, Ali Ozgur Ersoy, Asiye Ugras Dikmen, Cemile Koca, Seval Erdinc, Dilek Uygur, Turhan Caglar, Kutay Biberoglu. The role of interleukin-17 in intrahepatic cholestasis of pregnancy. The Journal of Maternal-Fetal & Neonatal Medicine 2016; 29(6) doi: 10.3109/14767058.2015.1028354
150
Ebru Biberoglu, Ayse Kirbas, Korkut Daglar, Ozgur Kara, Erdem Karabulut, Halil Ibrahim Yakut, Nuri Danisman. Role of inflammation in intrahepatic cholestasis of pregnancy. Journal of Obstetrics and Gynaecology Research 2016; 42(3) doi: 10.1111/jog.12902
151
Cynthia R. L. Webster, Andrea N. Johnston, M. Sawkat Anwer. Protein kinase Cδ protects against bile acid apoptosis by suppressing proapoptotic JNK and BIM pathways in human and rat hepatocytes. American Journal of Physiology-Gastrointestinal and Liver Physiology 2014; 307(12) doi: 10.1152/ajpgi.00165.2014
152
Katrin Panzitt, Emilian Jungwirth, Elisabeth Krones, Jae Man Lee, Marion Pollheimer, Gerhard G. Thallinger, Dagmar Kolb-Lenz, Rui Xiao, Anders Thorell, Michael Trauner, Peter Fickert, Hanns-Ulrich Marschall, David D. Moore, Martin Wagner. FXR-dependent Rubicon induction impairs autophagy in models of human cholestasis. Journal of Hepatology 2020; 72(6) doi: 10.1016/j.jhep.2020.01.014
153
Dongke Yu, Shi‐Ying Cai, Albert Mennone, Pamela Vig, James L. Boyer. Cenicriviroc, a cytokine receptor antagonist, potentiates all‐trans retinoic acid in reducing liver injury in cholestatic rodents. Liver International 2018; 38(6) doi: 10.1111/liv.13698
154
Mohammad Mehdi Ommati, Ali Amjadinia, Khadijeh Mousavi, Negar Azarpira, Akram Jamshidzadeh, Reza Heidari. N-acetyl cysteine treatment mitigates biomarkers of oxidative stress in different tissues of bile duct ligated rats. Stress 2021; 24(2) doi: 10.1080/10253890.2020.1777970
155
Wei Jia, Guoxiang Xie, Weiping Jia. Bile acid–microbiota crosstalk in gastrointestinal inflammation and carcinogenesis. Nature Reviews Gastroenterology & Hepatology 2018; 15(2) doi: 10.1038/nrgastro.2017.119
156
Rui Shen, Lixin Ke, Qiao Li, Xi Dang, Shunli Shen, Jianming Shen, Shaoqiang Li, Lijian Liang, Baogang Peng, Ming Kuang, Yi Ma, Zhonghan Yang, Yunpeng Hua. Abnormal bile acid-microbiota crosstalk promotes the development of hepatocellular carcinoma. Hepatology International 2022; 16(2) doi: 10.1007/s12072-022-10299-7
157
Ying Ding, Sheng-Xiang Rao, Caizhong Chen, Renchen Li, Meng-Su Zeng. Potential of Gd-EOB-DTPA-enhanced MR imaging for evaluation of bile duct ligation-induced liver injury in rabbits. Hepatology International 2015; 9(2) doi: 10.1007/s12072-014-9595-8
158
Yilin Sun, Shengbao Cai, Yuanyue Zhang, Nan Ma, Junjie Yi, Xiaosong Hu, Tao Wang. Protective Effect of Rhus chinensis Mill. Fruits on 3,5-Diethoxycarbonyl-1,4-Dihydrocollidine-Induced Cholestasis in Mice via Ameliorating Oxidative Stress and Inflammation. Nutrients 2022; 14(19) doi: 10.3390/nu14194090
159
Shengjie Ren, Chunfang Cai, Guangtong Cui, Qin Ni, Rong Jiang, Xiong Su, Qianqian Wang, Wen Chen, Junbiao Zhang, Ping Wu, Jianqiao Lu, Yuantu Ye. High dosages of pectin and cellulose cause different degrees of damage to the livers and intestines of Pelteobagrus fulvidraco. Aquaculture 2020; 514 doi: 10.1016/j.aquaculture.2019.734445
160
Benjamin L. Woolbright, Hartmut Jaeschke. Therapeutic targets for cholestatic liver injury. Expert Opinion on Therapeutic Targets 2016; 20(4) doi: 10.1517/14728222.2016.1103735
161
David E. Amacher, Shelli J. Schomaker, Jiri Aubrecht. Development of Blood Biomarkers for Drug-Induced Liver Injury: An Evaluation of Their Potential for Risk Assessment and Diagnostics. Molecular Diagnosis & Therapy 2013; 17(6) doi: 10.1007/s40291-013-0049-0
162
Yulia Shulpekova, Maria Zharkova, Pyotr Tkachenko, Igor Tikhonov, Alexander Stepanov, Alexandra Synitsyna, Alexander Izotov, Tatyana Butkova, Nadezhda Shulpekova, Natalia Lapina, Vladimir Nechaev, Svetlana Kardasheva, Alexey Okhlobystin, Vladimir Ivashkin. The Role of Bile Acids in the Human Body and in the Development of Diseases. Molecules 2022; 27(11) doi: 10.3390/molecules27113401
163
Xiaozhuan Lin, Xuan Zhu, Yan Xin, Peiwen Zhang, Yunjun Xiao, Taiping He, Honghui Guo. Intermittent Fasting Alleviates Non‐Alcoholic Steatohepatitis by Regulating Bile Acid Metabolism and Promoting Fecal Bile Acid Excretion in High‐Fat and High‐Cholesterol Diet Fed Mice. Molecular Nutrition & Food Research 2023; 67(14) doi: 10.1002/mnfr.202200595
164
Natalia Nuño‐Lámbarri, Varenka J Barbero‐Becerra, Misael Uribe, Norberto C Chávez‐Tapia. Elevated cholesterol levels have a poor prognosis in a cholestasis scenario. Journal of Biochemical and Molecular Toxicology 2017; 31(1) doi: 10.1002/jbt.21831
165
Jianing Li, Paul A. Dawson. Animal models to study bile acid metabolism. Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease 2019; 1865(5) doi: 10.1016/j.bbadis.2018.05.011
166
Marta Melis, Rebecca Marino, Jianmin Tian, Carla Johnson, Rahil Sethi, Michael Oertel, Ira J. Fox, Joseph Locker. Mechanism and Effect of HNF4α Decrease in a Rat Model of Cirrhosis and Liver Failure. Cellular and Molecular Gastroenterology and Hepatology 2024; 17(3) doi: 10.1016/j.jcmgh.2023.11.009
167
Xu Wang, Tihong Shao, Ran Tian, Jia Liu, Yi Wei, Li Wang, Fengchun Zhang. Clinical characteristics of dyslipidemia in patients with primary biliary cholangitis: a single-center experience in China. Clinical Rheumatology 2025; 44(10) doi: 10.1007/s10067-025-07662-y
168
Tiangang Li, Mohammad Nazmul Hasan, Lijie Gu. Bile acids regulation of cellular stress responses in liver physiology and diseases. eGastroenterology 2024; 2(2) doi: 10.1136/egastro-2024-100074
169
Jianchao Li, Lu Han, Shu Feng, Guoyuan Lin, Gaoliang Zou, Tao Huang, Tao Ran, Xueke Zhao. Glycochenodeoxycholic acid induces the release of IL-1beta from L02 cells via the NLRP3/caspase-1/GSDMD pathway to activate LX2 cells. Journal of Inflammation Research 2025;  doi: 10.2147/JIR.S532042
170
Tirthadipa Pradhan-Sundd, Satdarshan Pal Monga. Blood‐Bile Barrier: Morphology, Regulation, and Pathophysiology. Gene Expression 2019; 19(2) doi: 10.3727/105221619X15469715711907
171
Benjamin L. Woolbright. Inflammation: Cause or consequence of chronic cholestatic liver injury. Food and Chemical Toxicology 2020; 137 doi: 10.1016/j.fct.2020.111133
172
André A. Santos, David Pires, Vanda Marques, Nicole Alesina, Elisa Herraez, Pavel Roudnický, Pedro M. Rodrigues, Ana Godinho-Santos, Ana Catarina Bravo, Catarina Gouveia, Susana Saraiva, Luís Correia, Ricardo Crespo, João Pereira da Silva, Marília Cravo, David Potesil, Zbyněk Zdráhal, Jesus M. Banales, Jose J.G. Marin, Joana Torres, Cecília M.P. Rodrigues. Primary bile acid shapes peripheral immunity in inflammatory bowel disease-associated primary sclerosing cholangitis. Clinical Science 2025; 139(12) doi: 10.1042/CS20256078
173
Benjamin L. Woolbright, Daniel J. Antoine, Rosalind E. Jenkins, Mary Lynn Bajt, B. Kevin Park, Hartmut Jaeschke. Plasma biomarkers of liver injury and inflammation demonstrate a lack of apoptosis during obstructive cholestasis in mice. Toxicology and Applied Pharmacology 2013; 273(3) doi: 10.1016/j.taap.2013.09.023
174
Danhua Zhu, Qingmiao Shi, Xiaoxi Ouyang, Yanhong Zhang, Xiaopeng Yu, Long Yang, Kunkai Su, Lanjuan Li. Integrative transcriptomic and metabolomic analyses of puerarin against cholestatic liver fibrosis. Current Molecular Pharmacology 2026; 19(1) doi: 10.1016/j.cmp.2026.04.003
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