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For: Savarino E, de Bortoli N, Zentilin P, Martinucci I, Bruzzone L, Furnari M, Marchi S, Savarino V. Alginate controls heartburn in patients with erosive and nonerosive reflux disease. World J Gastroenterol 2012; 18(32): 4371-4378 [PMID: 22969201 DOI: 10.3748/wjg.v18.i32.4371]
URL: https://www.wjgnet.com/1007-9327/full/v18/i32/4371.htm
Number Citing Articles
1
Jerome R Lechien, Francois Mouawad, Maria R Barillari, Andrea Nacci, Seyyedeh Maryam Khoddami, Necati Enver, Sampath Kumar Raghunandhan, Christian Calvo-Henriquez, Young-Gyu Eun, Sven Saussez. Treatment of laryngopharyngeal reflux disease: A systematic reviewWorld Journal of Clinical Cases 2019; 7(19): 2995-3011 doi: 10.12998/wjcc.v7.i19.2995
2
Salvatore Tolone, Edoardo Savarino, Nicola de Bortoli, Marzio Frazzoni, Manuele Furnari, Antonio d’Alessandro, Roberto Ruggiero, Giovanni Docimo, Luigi Brusciano, Simona Gili, Raffaele Pirozzi, Simona Parisi, Carmine Colella, Mariachiara Bondanese, Beniamino Pascotto, NunzioMattia Buonomo, Vincenzo Savarino, Ludovico Docimo. Esophagogastric junction morphology assessment by high resolution manometry in obese patients candidate to bariatric surgeryInternational Journal of Surgery 2016; 28: S109 doi: 10.1016/j.ijsu.2015.12.047
3
Nunzio Ranaldo, Giuseppe Losurdo, Andrea Iannone, Mariabeatrice Principi, Michele Barone, Massimo De Carne, Enzo Ierardi, Alfredo Di Leo. Tailored therapy guided by multichannel intraluminal impedance pH monitoring for refractory non-erosive reflux diseaseCell Death & Disease 2017; 8(9): e3040 doi: 10.1038/cddis.2017.436
4
Michael T. Murray, John Nowicki. Textbook of Natural Medicine2020; : 1337 doi: 10.1016/B978-0-323-43044-9.00172-2
5
S.M. Freys, J. Heimbucher. Reflux und Hiatushernie im Spannungsfeld zwischen konservativer und operativer TherapieDer Chirurg 2014; 85(12): 1046 doi: 10.1007/s00104-014-2804-0
6
Nicola de Bortoli, Irene Martinucci, Edoardo V. Savarino, Marzio Frazzoni, Radu Tutuian, Salvatore Tolone, Paolo Piaggi, Manuele Furnari, Salvatore Russo, Lorenzo Bertani, Lorenzo Macchia, Vincenzo Savarino, Santino Marchi. Manually calculated oesophageal bolus clearance time increases in parallel with reflux severity at impedance-pH monitoringDigestive and Liver Disease 2015; 47(12): 1027 doi: 10.1016/j.dld.2015.08.010
7
S. Tolone, C. de Cassan, N. de Bortoli, S. Roman, F. Galeazzi, R. Salvador, E. Marabotto, M. Furnari, P. Zentilin, S. Marchi, R. Bardini, G. C. Sturniolo, V. Savarino, E. Savarino. Esophagogastric junction morphology is associated with a positive impedance‐pH monitoring in patients with GERDNeurogastroenterology & Motility 2015; 27(8): 1175 doi: 10.1111/nmo.12606
8
Amol Sharma, Jigar Bhagatwala. Dietary Interventions in Gastrointestinal Diseases2019; : 73 doi: 10.1016/B978-0-12-814468-8.00006-5
9
Lucas A.D. Nicolau, Francisco J. Batista-Lima, Ana P.M. Santana, Thiago M.A.L. Sales, João P. Carmo-Neto, Gutierres B. Freitas, Taiane M. Oliveira, Jand V.R. Medeiros, Durcilene A. Silva, Chung Lee, Philip J. Woodland, Pedro M.G. Soares, Mariana L. Vale, Armênio A. Santos, Daniel Sifrim, Marcellus H.L.P. Souza. Cashew gum, a biopolymer, topically protects oesophageal mucosa in non erosive reflux disease: A promising translational studyCarbohydrate Polymers 2019; 226: 115205 doi: 10.1016/j.carbpol.2019.115205
10
Thomas A. Zikos, John O. Clarke. Non-acid Reflux: When It Matters and Approach to ManagementCurrent Gastroenterology Reports 2020; 22(9) doi: 10.1007/s11894-020-00780-4
11
Edoardo Savarino, Patrizia Zentilin, Vincenzo Savarino. NERD: an umbrella term including heterogeneous subpopulationsNature Reviews Gastroenterology & Hepatology 2013; 10(6): 371 doi: 10.1038/nrgastro.2013.50
12
Edy Ippolito, Barnaba Floreno, Carla Germana Rinaldi, Lucio Trodella, Federica Loretta Meroni, Aurelia Iurato, Rolando Maria D’Angelillo, Sara Ramella, Michele Fiore. Efficacy of a Propolis-Based Syrup (FARINGEL) in Preventing Radiation-Induced Esophagitis in Locally Advanced Lung CancerChemotherapy 2018; 63(2): 76 doi: 10.1159/000487897
13
Ahmed Al-Marhabi, Ahmed Hashem, Bader Faiyaz Zuberi, Charles Onyekwere, Imran Lodhi, Mohamed Mounir, Saad Alkhowaiter, Sameer Al Awadhi, Vasudevan G. Naidoo, Yasser Hamada. The views of African and Middle Eastern Gastroenterologists on the management of mild-to-moderate, non-erosive gastro-esophageal reflux disease (GERD)Expert Review of Gastroenterology & Hepatology 2022; 16(3): 217 doi: 10.1080/17474124.2022.2043744
14
Mentore Ribolsi, Nicola De Bortoli, Marzio Frazzoni, Lorenzo Marchetti, Edoardo Savarino, Michele Cicala. Proximal esophageal impedance baseline increases the yield of impedance‐pH and is associated with response to PPIs in chronic cough patientsNeurogastroenterology & Motility 2024; 36(5) doi: 10.1111/nmo.14775
15
Takahiro Funami, Makoto Nakauma. Cation-responsive food polysaccharides and their usage in food and pharmaceutical products for improved quality of lifeFood Hydrocolloids 2023; 141: 108675 doi: 10.1016/j.foodhyd.2023.108675
16
Nicola de Bortoli, C. Prakash Gyawali, Marzio Frazzoni, Salvatore Tolone, Leonardo Frazzoni, Eleonora Vichi, Pierfrancesco Visaggi, Massimo Bellini, Elisa Marabotto, Roberto Penagini, Vincenzo Savarino, Santino Marchi, Edoardo V. Savarino. Bile reflux in patients with nerd is associated with more severe heartburn and lower values of mean nocturnal baseline impedance and chemical clearanceNeurogastroenterology & Motility 2020; 32(12) doi: 10.1111/nmo.13919
17
Nicola de Bortoli, Andrea Ottonello, Frank Zerbib, Daniel Sifrim, C. Prakash Gyawali, Edoardo Savarino. Between GERD and NERD: the relevance of weakly acidic refluxAnnals of the New York Academy of Sciences 2016; 1380(1): 218 doi: 10.1111/nyas.13169
18
Brigida Barberio, Pierfrancesco Visaggi, Edoardo Savarino, Nicola de Bortoli, Christopher J. Black, Alexander C. Ford. Comparison of acid‐lowering drugs for endoscopy negative reflux disease: Systematic review and network Meta‐AnalysisNeurogastroenterology & Motility 2023; 35(1) doi: 10.1111/nmo.14469
19
AVIJIT MAZUMDER, NAVEEN KUMAR, SAUMYA DAS. A Comprehensive Review of Gastroesophageal Reflux Disease (GERD) Treatment and its Clinical PerspectivesInternational Journal of Pharmaceutical Sciences and Nanotechnology(IJPSN) 2023; 16(6): 7093 doi: 10.37285/ijpsn.2023.16.6.9
20
C. Prakash Gyawali, Ronnie Fass. Management of Gastroesophageal Reflux DiseaseGastroenterology 2018; 154(2): 302 doi: 10.1053/j.gastro.2017.07.049
21
Amir Hossein Faghihi Kashani, Ghazaleh Heydarirad, Seyde Sedighe Yousefi, Rasool Choopani, Mohamad Kamalinejad, Shahnaz Karkon Varnosfaderani, Seyed Hamdollah Mosavat. Effects of “Satureja hortensis L.” on Improving Adult Gastroesophageal Reflux Disease: A Double-Blinded, Randomized, Controlled Clinical TrialIranian Red Crescent Medical Journal 2018; 20(2) doi: 10.5812/ircmj.57953
22
Dhalendra Kothale, Utsav Verma, Nagesh Dewangan, Partha Jana, Ankit Jain, Dharmendra Jain. Alginate as Promising Natural Polymer for Pharmaceutical, Food, and Biomedical ApplicationsCurrent Drug Delivery 2020; 17(9): 755 doi: 10.2174/1567201817666200810110226
23
N. de Bortoli, G. Guidi, I. Martinucci, E. Savarino, H. Imam, L. Bertani, S. Russo, R. Franchi, L. Macchia, M. Furnari, L. Ceccarelli, V. Savarino, S. Marchi. Voluntary and controlled weight loss can reduce symptoms and proton pump inhibitor use and dosage in patients with gastroesophageal reflux disease: a comparative studyDiseases of the Esophagus 2016; 29(2): 197 doi: 10.1111/dote.12319
24
Ankur Kumar, Ashish Kothari, Prashant Kumar, Arpana Singh, Kanchan Tripathi, Jitender Gairolla, Manju Pai, Balram Ji Omar. Alginate - Applications and Future PerspectivesBiochemistry 2024; 52 doi: 10.5772/intechopen.110650
25
Elisa Marabotto, Andrea Pasta, Francesco Calabrese, Mentore Ribolsi, Amir Mari, Vincenzo Savarino, Edoardo Vincenzo Savarino. The Clinical Spectrum of Gastroesophageal Reflux Disease: Facts and FictionsVisceral Medicine 2024; 40(5): 242 doi: 10.1159/000536583
26
M. Ribolsi, E. Savarino, N. De Bortoli, P. Balestrieri, M. Furnari, I. Martinucci, M. Casale, F. Greco, F. Salvinelli, V. Savarino, S. Marchi, M. Cicala. Reflux pattern and role of impedance‐pH variables in predicting PPI response in patients with suspected GERD‐related chronic coughAlimentary Pharmacology & Therapeutics 2014; 40(8): 966 doi: 10.1111/apt.12919
27
N. de Bortoli, I. Martinucci, E. Savarino, M. Bellini, A. J. Bredenoord, R. Franchi, L. Bertani, M. Furnari, V. Savarino, C. Blandizzi, S. Marchi. Proton pump inhibitor responders who are not confirmed as GERD patients with impedance and pH monitoring: who are they?Neurogastroenterology & Motility 2014; 26(1): 28 doi: 10.1111/nmo.12221
28
Scott B. Simpson, Katherine Y. Qian, Raymond Sacks, Daniel Novakovic, Rebecca Simpson, Hans Wall. Observational cohort study: Getting to the bottom of laryngopharyngeal reflux—It’s a motility disorder and not just about the acidGastroHep 2019; 1(5): 223 doi: 10.1002/ygh2.361
29
Nicola de Bortoli, Irene Martinucci, Edoardo Savarino, Radu Tutuian, Marzio Frazzoni, Paolo Piaggi, Lorenzo Bertani, Manuele Furnari, Riccardo Franchi, Salvatore Russo, Massimo Bellini, Vincenzo Savarino, Santino Marchi. Association Between Baseline Impedance Values and Response Proton Pump Inhibitors in Patients With HeartburnClinical Gastroenterology and Hepatology 2015; 13(6): 1082 doi: 10.1016/j.cgh.2014.11.035
30
Andrea Pasta, Filippo Pelizzaro, Elisa Marabotto, Francesco Calabrese, Elena Formisano, Shirin Djahandideh Sheijani, Giovanni Brandimarte, Giampiero Manes, Antonietta Gerarda Gravina, Edoardo Vincenzo Savarino. Patient journey in gastroesophageal reflux disease: real-world perspectives from Italian gastroenterologists, primary care physicians, and ENT specialistsTherapeutic Advances in Gastroenterology 2024; 17 doi: 10.1177/17562848241239590
31
Maria Yousaf, Jorabar Singh Nirwan, Alan M. Smith, Peter Timmins, Barbara R. Conway, Muhammad Usman Ghori. Raft‐forming polysaccharides for the treatment of gastroesophageal reflux disease (GORD): Systematic reviewJournal of Applied Polymer Science 2019; 136(40) doi: 10.1002/app.48012
32
Thiago Meneses Araújo Leite Sales, Lucas Antonio Duarte Nicolau, Rhubens Levy Moreira Rodrigues, Renata Rocha Nascimento, Suliana Mesquita Paula, Humberto Barbosa da Costa-Filho, Francisco Felipe Bezerra, Gustavo Ramalho Cardoso Santos, Francisco Clark Nogueira Barros, Poliana de Oliveira Cavalcante Alencar, Ana Lúcia Ponte Freitas, Miguel Ângelo Nobre-Souza, Armênio Aguiar Santos, Daniel Sifrim, Pedro Marcos Gomes Soares, Renan Oliveira Silva, Marcellus Henrique Loiola Ponte Souza. Polysaccharide from Gracilaria caudata protects the human esophageal mucosal barrier: A differential topical effect and structural dependenceInternational Journal of Biological Macromolecules 2020; 150: 354 doi: 10.1016/j.ijbiomac.2020.02.074
33
Irene Martinucci, Giada Guidi, Edoardo V. Savarino, Marzio Frazzoni, Salvatore Tolone, Leonardo Frazzoni, Lorenzo Fuccio, Lorenzo Bertani, Giorgia Bodini, Linda Ceccarelli, Vincenzo Savarino, Santino Marchi, Nicola de Bortoli. Vegetal and Animal Food Proteins Have a Different Impact in the First Postprandial Hour of Impedance-pH Analysis in Patients with HeartburnGastroenterology Research and Practice 2018; 2018: 1 doi: 10.1155/2018/7572430
34
R. Vardar, M. Keskin, E. Valitova, B. Bayrakci, E. Yildirim, S. Bor. Effect of alginate in patients with GERD hiatal hernia mattersDiseases of the Esophagus 2017; 30(10): 1 doi: 10.1093/dote/dox039
35
Yadav Ambedkar Kumar, Li Yu, Xianghuai Xu, Yadav Abishek, Yadav Dhananjay. Non-Acid GERC: Pathogenesis, Diagnosis and ManagementInternational Journal of Innovative Science and Research Technology (IJISRT) 2024; : 56 doi: 10.38124/ijisrt/IJISRT24MAY390
36
Nicola de Bortoli, Leonardo Frazzoni, Edoardo V Savarino, Marzio Frazzoni, Irene Martinucci, Aleksandra Jania, Salvatore Tolone, Michele Scagliarini, Massimo Bellini, Elisa Marabotto, Manuele Furnari, Giorgia Bodini, Salvatore Russo, Lorenzo Bertani, Veronica Natali, Lorenzo Fuccio, Vincenzo Savarino, Corrado Blandizzi, Santino Marchi. Functional Heartburn Overlaps With Irritable Bowel Syndrome More Often than GERDAmerican Journal of Gastroenterology 2016; 111(12): 1711 doi: 10.1038/ajg.2016.432
37
Romeo Bardini, Sabrina Rampado, Renato Salvador, Lisa Zanatta, Imerio Angriman, Silvia Degasperi, Angelica Ganss, Edoardo Savarino. A modification of Nissen fundoplication improves patients' outcome and may reduce procedure-related failure rateInternational Journal of Surgery 2017; 38: 83 doi: 10.1016/j.ijsu.2016.12.072
38
Andrea Tenca, Nicola de Bortoli, Aurelio Mauro, Marzio Frazzoni, Edoardo Savarino, Sara Massironi, Salvatore Russo, Lorenzo Bertani, Santino Marchi, Roberto Penagini. Esophageal chemical clearance and baseline impedance values in patients with chronic autoimmune atrophic gastritis and gastro-esophageal reflux diseaseDigestive and Liver Disease 2017; 49(9): 978 doi: 10.1016/j.dld.2017.04.005
39
Peter J. Kahrilas, Guy Boeckxstaens, Andre J.P.M. Smout. Management of the patient with incomplete response to PPI therapyBest Practice & Research Clinical Gastroenterology 2013; 27(3): 401 doi: 10.1016/j.bpg.2013.06.005
40
Edoardo Savarino, Patrizia Zentilin, Elisa Marabotto, Giorgia Bodini, Marco Della Coletta, Marzio Frazzoni, Nicola de Bortoli, Irene Martinucci, Salvatore Tolone, Gaia Pellegatta, Vincenzo Savarino. A review of pharmacotherapy for treating gastroesophageal reflux disease (GERD)Expert Opinion on Pharmacotherapy 2017; 18(13): 1333 doi: 10.1080/14656566.2017.1361407
41
Patrizia Zentilin, Vincenzo Savarino, Elisa Marabotto, Giuseppe Murdaca, Alberto Sulli, Carmen Pizzorni, Francesco Puppo, Edoardo Savarino. Esophageal baseline impedance levels allow the identification of esophageal involvement in patients with systemic sclerosisSeminars in Arthritis and Rheumatism 2018; 47(4): 569 doi: 10.1016/j.semarthrit.2017.08.004
42
Pierfrancesco Visaggi, Luisa Bertin, Andrea Pasta, Francesco Calabrese, Matteo Ghisa, Elisa Marabotto, Mentore Ribolsi, Vincenzo Savarino, Nicola de Bortoli, Edoardo Vincenzo Savarino. Pharmacological management of gastro-esophageal reflux disease: state of the art in 2024Expert Opinion on Pharmacotherapy 2024; 25(15): 2077 doi: 10.1080/14656566.2024.2416585
43
Karl Hermann Fuchs, Benjamin Babic, Wolfram Breithaupt, Bernard Dallemagne, Abe Fingerhut, Edgar Furnee, Frank Granderath, Peter Horvath, Peter Kardos, Rudolph Pointner, Edoardo Savarino, Maud Van Herwaarden-Lindeboom, Giovanni Zaninotto. EAES recommendations for the management of gastroesophageal reflux diseaseSurgical Endoscopy 2014; 28(6): 1753 doi: 10.1007/s00464-014-3431-z
44
Stefano Kayali, Francesco Calabrese, Andrea Pasta, Elisa Marabotto, Giorgia Bodini, Manuele Furnari, Edoardo V. Savarino, Vincenzo Savarino, Edoardo G. Giannini, Patrizia Zentilin. Effect of hiatal hernia and esophagogastric junction morphology on esophageal motility: Evidence from high‐resolution manometry studiesNeurogastroenterology & Motility 2024; 36(12) doi: 10.1111/nmo.14929
45
I. Martinucci, N. de Bortoli, E. Savarino, P. Piaggi, M. Bellini, A. Antonelli, V. Savarino, M. Frazzoni, S. Marchi. Esophageal baseline impedance levels in patients with pathophysiological characteristics of functional heartburnNeurogastroenterology & Motility 2014; 26(4): 546 doi: 10.1111/nmo.12299
46
Pierfrancesco Visaggi, Giulio Del Corso, C. Prakash Gyawali, Matteo Ghisa, Federica Baiano Svizzero, Delio Stefani Donati, Arianna Venturini, Vincenzo Savarino, Roberto Penagini, Sebastian Zeki, Massimo Bellini, Edoardo V. Savarino, Nicola de Bortoli. Ambulatory pH-Impedance Findings Confirm That Grade B Esophagitis Provides Objective Diagnosis of Gastroesophageal Reflux DiseaseAmerican Journal of Gastroenterology 2023; 118(5): 794 doi: 10.14309/ajg.0000000000002173
47
I. Martinucci, E. V. Savarino, J. E. Pandolfino, S. Russo, M. Bellini, S. Tolone, R. Tutuian, S. Roman, M. Furnari, M. Frazzoni, L. Macchia, V. Savarino, S. Marchi, N. de Bortoli. Vigor of peristalsis during multiple rapid swallows is inversely correlated with acid exposure time in patients with NERDNeurogastroenterology & Motility 2016; 28(2): 243 doi: 10.1111/nmo.12719
48
Mark Fox. Update Motility Disorders: Gastro-Oesophageal Reflux Disease – Diagnostic and Conservative ApproachVisceral Medicine 2024; : 1 doi: 10.1159/000541358
49
Mentore Ribolsi, Lorenzo Marchetti, Lucrezia Maria Olmi, Michele Cicala, Edoardo Savarino. Esophageal chest pain resembles heartburn in reflux metrics and response to proton pump inhibitor therapyNeurogastroenterology & Motility 2024;  doi: 10.1111/nmo.14953
50
Hye-Kyung Jung, Chung Hyun Tae, Kyung Ho Song, Seung Joo Kang, Jong Kyu Park, Eun Jeong Gong, Jeong Eun Shin, Hyun Chul Lim, Sang Kil Lee, Da Hyun Jung, Yoon Jin Choi, Seung In Seo, Joon Sung Kim, Jung Min Lee, Beom Jin Kim, Sun Hyung Kang, Chan Hyuk Park, Suck Chei Choi, Joong Goo Kwon, Kyung Sik Park, Moo In Park, Tae Hee Lee, Seung Young Kim, Young Sin Cho, Han Hong Lee, Kee Wook Jung, Do Hoon Kim, Hee Seok Moon, Hirota Miwa, Chien-Lin Chen, Sutep Gonlachanvit, Uday C Ghoshal, Justin C Y Wu, Kewin T H Siah, Xiaohua Hou, Tadayuki Oshima, Mi-Young Choi, Kwang Jae Lee. 2020 Seoul Consensus on the Diagnosis and Management of Gastroesophageal Reflux DiseaseJournal of Neurogastroenterology and Motility 2021; 27(4): 453 doi: 10.5056/jnm21077
51
Nicole Pizzorni, Federico Ambrogi, Angelo Eplite, Sibora Rama, Carlo Robotti, Jerome Lechien, Antonio Schindler. Magnesium alginate versus proton pump inhibitors for the treatment of laryngopharyngeal reflux: a non-inferiority randomized controlled trialEuropean Archives of Oto-Rhino-Laryngology 2022; 279(5): 2533 doi: 10.1007/s00405-021-07219-0
52
N. de Bortoli, I. Martinucci, E. Savarino, R. Franchi, L. Bertani, S. Russo, L. Ceccarelli, F. Costa, M. Bellini, C. Blandizzi, V. Savarino, S. Marchi. Lower pH values of weakly acidic refluxes as determinants of heartburn perception in gastroesophageal reflux disease patients with normal esophageal acid exposureDiseases of the Esophagus 2016; 29(1): 3 doi: 10.1111/dote.12284
53
Pierfrancesco Visaggi, Matteo Ghisa, Giulio Del Corso, Federica Baiano Svizzero, Lucia Mariani, Salvatore Tolone, Marzio Frazzoni, Andrea Buda, Massimo Bellini, Vincenzo Savarino, Roberto Penagini, C. Prakash Gyawali, Edoardo V. Savarino, Nicola de Bortoli. Chicago classification v4.0 protocol improves specificity and accuracy of diagnosis of oesophagogastric junction outflow obstructionAlimentary Pharmacology & Therapeutics 2022; 56(4): 606 doi: 10.1111/apt.17101
54
Nicola de Bortoli, Irene Martinucci, Lorenzo Bertani, Salvatore Russo, Riccardo Franchi, Manuele Furnari, Salvatore Tolone, Giorgia Bodini, Valeria Bolognesi, Massimo Bellini, Vincenzo Savarino, Santino Marchi, Edoardo Vincenzo Savarino. Esophageal testing: What we have so farWorld Journal of Gastrointestinal Pathophysiology 2016; 7(1): 72-85 doi: 10.4291/wjgp.v7.i1.72
55
Mark Fox, C Prakash Gyawali. Dietary factors involved in GERD managementBest Practice & Research Clinical Gastroenterology 2023; : 101826 doi: 10.1016/j.bpg.2023.101826
56
S. Tolone, N. De Bortoli, E. Marabotto, C. de Cassan, G. Bodini, S. Roman, M. Furnari, V. Savarino, L. Docimo, E. Savarino. Esophagogastric junction contractility for clinical assessment in patients with GERD: a real added value?Neurogastroenterology & Motility 2015; 27(10): 1423 doi: 10.1111/nmo.12638
57
Irene Martinucci, Nicola de Bortoli, Edoardo Savarino, Andrea Nacci, Salvatore Osvaldo Romeo, Massimo Bellini, Vincenzo Savarino, Bruno Fattori, Santino Marchi. Optimal treatment of laryngopharyngeal reflux diseaseTherapeutic Advances in Chronic Disease 2013; 4(6): 287 doi: 10.1177/2040622313503485