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For: Speca S, Giusti I, Rieder F, Latella G. Cellular and molecular mechanisms of intestinal fibrosis. World J Gastroenterol 2012; 18(28): 3635-3661 [PMID: 22851857 DOI: 10.3748/wjg.v18.i28.3635]
URL: https://www.wjgnet.com/1007-9327/full/v18/i28/3635.htm
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1
Yuki Hayashi, Hiroshi Nakase. The Molecular Mechanisms of Intestinal Inflammation and Fibrosis in Crohn’s Disease. Frontiers in Physiology 2022; 13 doi: 10.3389/fphys.2022.845078
2
Rong Yan, Armand Ghozati, Haiming Chen, Kalyan Kumar Pasunooti, Waliul Islam, Ling Li, Florin M. Selaru. Modeling intestinal fibrosis in inflammatory bowel disease: translational animal models and ex vivo platforms. Journal of Gastroenterology 2026;  doi: 10.1007/s00535-026-02527-w
3
George S. Hussey, Timothy J. Keane, Stephen F. Badylak. The extracellular matrix of the gastrointestinal tract: a regenerative medicine platform. Nature Reviews Gastroenterology & Hepatology 2017; 14(9) doi: 10.1038/nrgastro.2017.76
4
Silvia D’Alessio, Federica Ungaro, Daniele Noviello, Sara Lovisa, Laurent Peyrin-Biroulet, Silvio Danese. Revisiting fibrosis in inflammatory bowel disease: the gut thickens. Nature Reviews Gastroenterology & Hepatology 2022; 19(3) doi: 10.1038/s41575-021-00543-0
5
Xiaomin Wu, Xiaoxuan Lin, Jinyu Tan, Zishan Liu, Jinshen He, Fan Hu, Yu Wang, Minhu Chen, Fen Liu, Ren Mao. Cellular and Molecular Mechanisms of Intestinal Fibrosis. Gut and Liver 2023; 17(3) doi: 10.5009/gnl220045
6
Liangjun Deng, Haihua Guo, Shanping Wang, Xiaoming Liu, Yue Lin, Rui Zhang, Wen Tan, Ivan Srejovic. The Attenuation of Chronic Ulcerative Colitis by (R)‐salbutamol in Repeated DSS‐Induced Mice. Oxidative Medicine and Cellular Longevity 2022; 2022(1) doi: 10.1155/2022/9318721
7
Bo Liu, Xuewei Bi, Yuqi He, Xiaoming Li. Decellularized Materials. 2021;  doi: 10.1007/978-981-33-6962-7_4
8
Giorgia Burrelli Scotti, Roberto Lorenzetti, Annalisa Aratari, Antonietta Lamazza, Enrico Fiori, Claudio Papi, Stefano Festa. Stricturing Crohn's disease: what is the role of endoscopic stenting? A systematic review. Clinical Endoscopy 2023; 56(6) doi: 10.5946/ce.2023.059
9
Yadi Guan, Yue Tan, Weiyu Liu, Jun Yang, Dongxu Wang, Di Pan, Yan Sun, Changqing Zheng. NF-E2-Related Factor 2 Suppresses Intestinal Fibrosis by Inhibiting Reactive Oxygen Species-Dependent TGF-β1/SMADs Pathway. Digestive Diseases and Sciences 2018; 63(2) doi: 10.1007/s10620-017-4710-z
10
Juana Mosele, Alba Macià, Maria-José Motilva. Metabolic and Microbial Modulation of the Large Intestine Ecosystem by Non-Absorbed Diet Phenolic Compounds: A Review. Molecules 2015; 20(9) doi: 10.3390/molecules200917429
11
Jacopo Di Gregorio, Roberta Sferra, Silvia Speca, Antonella Vetuschi, Caroline Dubuquoy, Pierre Desreumaux, Simona Pompili, Loredana Cristiano, Eugenio Gaudio, Vincenzo Flati, Giovanni Latella, Masaru Katoh. Role of glycogen synthase kinase-3β and PPAR-γ on epithelial-to-mesenchymal transition in DSS-induced colorectal fibrosis. PLOS ONE 2017; 12(2) doi: 10.1371/journal.pone.0171093
12
Amna Al-Araimi, Ishraq A. Al Kindi, Asma Bani Oraba, Amira AlKharusi, Badreldin H. Ali, Razan Zadjali, Shadia Al Sinawi, Ibrahim Al-Haddabi, Fahad Zadjali. Gum Arabic Supplementation Suppresses Colonic Fibrosis After Acute Colitis by Reducing Transforming Growth Factor β1 Expression. Journal of Medicinal Food 2021; 24(12) doi: 10.1089/jmf.2021.0007
13
An Liu, Xiao-Juan Zhu, Wei-Dong Sun, Shuang-Zhou Bi, Chen-Ying Zhang, Jiang-Hua Li. Nicotinamide N-methyltransferase in inflammatory bowel disease: Multidimensional regulation, mechanistic insights, and therapeutic potential. Experimental Cell Research 2026; 461(1) doi: 10.1016/j.yexcr.2026.115096
14
Jin-Sil Park, Jeong Won Choi, JooYeon Jhun, Ji Ye Kwon, Bo-In Lee, Chul Woo Yang, Sung-Hwan Park, Mi-La Cho. Lactobacillus acidophilus Improves Intestinal Inflammation in an Acute Colitis Mouse Model by Regulation of Th17 and Treg Cell Balance and Fibrosis Development. Journal of Medicinal Food 2018; 21(3) doi: 10.1089/jmf.2017.3990
15
Chaohui Yan, Xi Luo, Yiwen Tang, Hong Chen, Shiting Qin, Yumei Huang, Chunhui Zeng, Ke Yang. Ampelopsin's mechanism in ameliorating acute lung injury: Insights from network pharmacology and experimental validation. European Journal of Integrative Medicine 2025; 80 doi: 10.1016/j.eujim.2025.102571
16
Edward Macarak, Joel Rosenbloom. Fibrostenotic Inflammatory Bowel Disease. 2018;  doi: 10.1007/978-3-319-90578-5_22
17
Giovanni Latella, Jacopo Di Gregorio, Vincenzo Flati, Florian Rieder, Ian C. Lawrance. Mechanisms of initiation and progression of intestinal fibrosis in IBD. Scandinavian Journal of Gastroenterology 2015; 50(1) doi: 10.3109/00365521.2014.968863
18
Mengli Yu, Wei Zhu, Jinhai Wang, Xueyang Chen, Xinjue He, Bingru Lin, Li Cen, Tianyu Zhou, Chao Lu, Chaohui Yu, Jing Sun. Caveolin-1 Alleviates Crohn’s Disease–induced Intestinal Fibrosis by Inhibiting Fibroblasts Autophagy Through Modulating Sequestosome 1. Inflammatory Bowel Diseases 2022; 28(6) doi: 10.1093/ibd/izab342
19
Jennifer Bailey. Editorial: Factors Promoting Development of Fibrosis in Crohn’s Disease. Frontiers in Medicine 2017; 4 doi: 10.3389/fmed.2017.00160
20
Jian Li, Lan Liu, Qiu Zhao, Min Chen. Role of Interleukin-17 in Pathogenesis of Intestinal Fibrosis in Mice. Digestive Diseases and Sciences 2020; 65(7) doi: 10.1007/s10620-019-05969-w
21
Yu Kyung Jun, So Hyun Kwon, Hee Tae Yoon, Hyunsun Park, Hosim Soh, Hyun Jung Lee, Jong Pil Im, Joo Sung Kim, Ji Won Kim, Seong-Joon Koh. Toll-like receptor 4 regulates intestinal fibrosis via cytokine expression and epithelial-mesenchymal transition. Scientific Reports 2020; 10(1) doi: 10.1038/s41598-020-76880-y
22
Pedro A. Ruiz Castro, Ulrike Kogel, Giuseppe Lo Sasso, Blaine W. Phillips, Alain Sewer, Bjorn Titz, Llenalia Garcia, Athanasios Kondylis, Emmanuel Guedj, Dariusz Peric, David Bornand, Remi Dulize, Celine Merg, Maica Corciulo, Nikolai V. Ivanov, Manuel C. Peitsch, Julia Hoeng. Anatabine ameliorates intestinal inflammation and reduces the production of pro-inflammatory factors in a dextran sulfate sodium mouse model of colitis. Journal of Inflammation 2020; 17(1) doi: 10.1186/s12950-020-00260-6
23
Claudio Bernardazzi, Fernando Castro, Heitor S. de Souza. Fibrostenotic Inflammatory Bowel Disease. 2018;  doi: 10.1007/978-3-319-90578-5_8
24
Maria Francesca Nanì, Ester Pagano, Paola De Cicco, Giuseppe Lucariello, Fabio Cattaneo, Francesca Paola Tropeano, Donatella Cicia, Rebecca Amico, Federica Raucci, Giuseppe Ercolano, Francesco Maione, Maria Michela Rinaldi, Fabiana Esposito, Rosario Ammendola, Gaetano Luglio, Raffaele Capasso, Alexandros Makriyannis, Stefania Petrosino, Francesca Borrelli, Barbara Romano, Angelo A Izzo. Pharmacological Inhibition of N-Acylethanolamine Acid Amidase (NAAA) Mitigates Intestinal Fibrosis Through Modulation of Macrophage Activity. Journal of Crohn's and Colitis 2025; 19(2) doi: 10.1093/ecco-jcc/jjae132
25
Onofrio A. Catalano, Michael S. Gee, Emanuele Nicolai, Francesco Selvaggi, Gianluca Pellino, Alberto Cuocolo, Angelo Luongo, Marco Catalano, Bruce R. Rosen, Debra Gervais, Mark G. Vangel, Andrea Soricelli, Marco Salvatore. Evaluation of Quantitative PET/MR Enterography Biomarkers for Discrimination of Inflammatory Strictures from Fibrotic Strictures in Crohn Disease. Radiology 2016; 278(3) doi: 10.1148/radiol.2015150566
26
Sun-Mi Yun, Seok-Ho Kim, Eun-Hee Kim. The Molecular Mechanism of Transforming Growth Factor-β Signaling for Intestinal Fibrosis: A Mini-Review. Frontiers in Pharmacology 2019; 10 doi: 10.3389/fphar.2019.00162
27
Ryuji Inoue, Lin-Hai Kurahara, Keizo Hiraishi. TRP channels in cardiac and intestinal fibrosis. Seminars in Cell & Developmental Biology 2019; 94 doi: 10.1016/j.semcdb.2018.11.002
28
Yuseok Moon. Handbook of Cancer and Immunology. 2024;  doi: 10.1007/978-3-030-80962-1_370-1
29
Jennifer C. Ku, Jacob Raiten, Yong Li. Understanding fibrosis: Mechanisms, clinical implications, current therapies, and prospects for future interventions. Biomedical Engineering Advances 2024; 7 doi: 10.1016/j.bea.2024.100118
30
Wan-Ying Li, Jun-Yang Liu, Zi-Xian Wang, Ke-Ying Wang, Chun-Xiang Huang, Wen He, Jia-Le Song. Sinapic Acid Attenuates Chronic DSS-Induced Intestinal Fibrosis in C57BL/6J Mice by Modulating NLRP3 Inflammasome Activation and the Autophagy Pathway. ACS Omega 2024; 9(1) doi: 10.1021/acsomega.3c07474
31
Kailiang Li, Monika Liszka, Changqing Zhou, Emily Brehm, Jodi A. Flaws, Romana A. Nowak. Prenatal exposure to a phthalate mixture leads to multigenerational and transgenerational effects on uterine morphology and function in mice. Reproductive Toxicology 2020; 93 doi: 10.1016/j.reprotox.2020.02.012
32
Shukai Zhan, Na Li, Caiguang Liu, Ren Mao, Dongxuan Wu, Tong Li, Minhu Chen, Xiaojun Zhuang, Zhirong Zeng. Intestinal Fibrosis and Gut Microbiota: Clues From Other Organs. Frontiers in Microbiology 2021; 12 doi: 10.3389/fmicb.2021.694967
33
Hyun Joo Lee. Therapeutic Potential of the Combination of Pentoxifylline and Vitamin-E in Inflammatory Bowel Disease: Inhibition of Intestinal Fibrosis. Journal of Clinical Medicine 2022; 11(16) doi: 10.3390/jcm11164713
34
Sara Lovisa, Giannicola Genovese, Silvio Danese. Role of Epithelial-to-Mesenchymal Transition in Inflammatory Bowel Disease. Journal of Crohn's and Colitis 2019; 13(5) doi: 10.1093/ecco-jcc/jjy201
35
Cui Zeng, Xinghuang Liu, Danping Xiong, Kaifang Zou, Tao Bai. Resolvin D1 Prevents Epithelial-to-Mesenchymal Transition and Reduces Collagen Deposition by Stimulating Autophagy in Intestinal Fibrosis. Digestive Diseases and Sciences 2022; 67(10) doi: 10.1007/s10620-021-07356-w
36
Yicheng Sun, Qiwen Chen, Chuyue Zhong, Yuxin Chen, Rui Zhao, Xixi He, Xinli Mao, Jiacheng Li, Zhenqiu Xing, Fang Wu. Beyond inflammation: exploring CAR-based cell therapy for fibrostenosing Crohn’s disease. Frontiers in Immunology 2026; 17 doi: 10.3389/fimmu.2026.1967353
37
Xiong-Xin Lei, Juan-Juan Hu, Chen-Yu Zou, Yan-Lin Jiang, Long-Mei Zhao, Xiu-Zhen Zhang, Ya-Xing Li, An-Ni Peng, Yu-Ting Song, Li-Ping Huang, Jesse Li-Ling, Hui-Qi Xie. Multifunctional two-component in-situ hydrogel for esophageal submucosal dissection for mucosa uplift, postoperative wound closure and rapid healing. Bioactive Materials 2023; 27 doi: 10.1016/j.bioactmat.2023.04.015
38
Peng Jun Xu, Zhou Jing Zhang, Jing Jin, Hai Yuan Xu, Ya Xin Gu, Qian Qian Yang, You Lang Zhou. CAR‐Engineered Cell Therapies Beyond Cancer: Reprogramming Fibrosis and Immune‐Mediated Inflammation. Advanced Science 2026; 13(54) doi: 10.1002/advs.77503
39
Huafeng Zhang, Bingwei Sun. Pleiotropic regulations of neutrophil receptors response to sepsis. Inflammation Research 2017; 66(3) doi: 10.1007/s00011-016-0993-3
40
Jianzhi Li, Jiangdong Yu, Yuming Liu, Li Hu, Bo Yang, Xiutian Zhou, Rui Wang, Yu Liang. Expression of the Matrix Metalloproteinases and the Tissue Inhibitor of Metalloproteinase Factors are Affected by Tetramethylpyrazine Treatment in a Renal Interstitial Fibrosis Rat Model. Journal of Hard Tissue Biology 2014; 23(3) doi: 10.2485/jhtb.23.309
41
Wen-Di Zhang, Dan-Dan Zhang, Xu Wang, Chen-Yang Li, Fan-Qin Li, Xin-Long Liu, Shi-Zhen Zhang, Wei Sun, Li-Jing Li, Han-Bing Wang, Peng Kong, Xiao-Qin Liu, De-Min Liu, Xiao-Lan Zhang, Ya-Bin Liu, Mei Han. Activation of the RSAD2-YTHDF1 axis in smooth muscle causes inflammatory bowel disease via intercellular mitochondrial transfer. Nature Communications 2025; 17(1) doi: 10.1038/s41467-025-67707-3
42
Giorgos Bamias, Li-Guo Jia, Fabio Cominelli. The tumor necrosis factor-like cytokine 1A/death receptor 3 cytokine system in intestinal inflammation. Current Opinion in Gastroenterology 2013; 29(6) doi: 10.1097/MOG.0b013e328365d3a2
43
Shashank Shrishrimal, Elizabeth Kosmacek, Arpita Chatterjee, McDonald Tyson, Rebecca Oberley-Deegan. The SOD Mimic, MnTE-2-PyP, Protects from Chronic Fibrosis and Inflammation in Irradiated Normal Pelvic Tissues. Antioxidants 2017; 6(4) doi: 10.3390/antiox6040087
44
Fan Wu, Qingqing Shao, Meilin Hu, Yan Zhao, Ruolan Dong, Ke Fang, Lijun Xu, Xin Zou, Fuer Lu, Jingbin Li, Guang Chen. Wu-Mei-Wan ameliorates chronic colitis-associated intestinal fibrosis through inhibiting fibroblast activation. Journal of Ethnopharmacology 2020; 252 doi: 10.1016/j.jep.2020.112580
45
Florian Rieder, Pranab K Mukherjee, William J Massey, Yan Wang, Claudio Fiocchi. Fibrosis in IBD: from pathogenesis to therapeutic targets. Gut 2024; 73(5) doi: 10.1136/gutjnl-2023-329963
46
Lucio Díaz‐Flores, Ricardo Gutiérrez, Koldo Lizartza, Miriam González Goméz, M. Del Pino García, Francisco J. Sáez, Lucio Díaz‐Flores, Juan F. Madrid. Behavior of In Situ Human Native Adipose Tissue CD34+ Stromal/Progenitor Cells During Different Stages of Repair. Tissue‐Resident CD34+ Stromal Cells as a Source of Myofibroblasts. The Anatomical Record 2015; 298(5) doi: 10.1002/ar.23086
47
Annunziata Scirocco, Paola Matarrese, Marilia Carabotti, Barbara Ascione, Walter Malorni, Carola Severi. Cellular and Molecular Mechanisms of Phenotypic Switch in Gastrointestinal Smooth Muscle. Journal of Cellular Physiology 2016; 231(2) doi: 10.1002/jcp.25105
48
Beatriz P. Costa, Ana C. Gonçalves, Ana M. Abrantes, Paulo Matafome, Raquel Seiça, Ana B. Sarmento-Ribeiro, Maria Filomena Botelho, Francisco Castro-Sousa. Teduglutide effects on gene regulation of fibrogenesis on an animal model of intestinal anastomosis. Journal of Surgical Research 2017; 216 doi: 10.1016/j.jss.2017.04.022
49
MERVE ERCIN, SELDA GEZGINCI-OKTAYOGLU, SEHNAZ BOLKENT. Exendin-4 inhibits small intestinal glucose sensing and absorption through repression of T1R2/T1R3 sweet taste receptor signalling in streptozotocin diabetic mice. Translational Research 2022; 246 doi: 10.1016/j.trsl.2022.03.012
50
Hidehito Maeda, Fumisato Sasaki, Yuko Morinaga, Masayuki Kabayama, Hiromichi Iwaya, Yuga Komaki, Shiho Arima, Yuichiro Nasu, Shiroh Tanoue, Shinichi Hashimoto, Shuji Kanmura, Akihiro Nishiguchi, Tetsushi Taguchi, Akio Ido. Covering Post-Endoscopic Submucosal Dissection Ulcers in Miniature Swine with Hexanoyl (Hx:C6) Group-Modified Alkaline-Treated Gelatin Porous Film (HAG) Induces Proper Healing by Decreasing Inflammation and Fibrosis. Digestion 2021; 102(3) doi: 10.1159/000509056
51
E. Bequet, C. Salée, N. Bletard, C. Massot, F. Fonzé, H. Sarter, D. Ley, S. Colinet, P. Delvenne, E. Louis, S. Vieujean, M-A. Meuwis. Distribution of epithelial endoplasmic reticulum stress-related proteins in adult and pediatric Crohn’s disease: Association with inflammation and fibrosis. Digestive and Liver Disease 2025; 57(6) doi: 10.1016/j.dld.2025.04.015
52
Jie Wang, Sinan Lin, Jonathan Mark Brown, David van Wagoner, Claudio Fiocchi, Florian Rieder. Novel mechanisms and clinical trial endpoints in intestinal fibrosis*. Immunological Reviews 2021; 302(1) doi: 10.1111/imr.12974
53
Iwona Buskiewicz, Sally Huber, DeLisa Fairweather. Vascular Responses to Pathogens. 2016;  doi: 10.1016/B978-0-12-801078-5.00012-1
54
Shaneice Nettleford, K. Prabhu. Selenium and Selenoproteins in Gut Inflammation—A Review. Antioxidants 2018; 7(3) doi: 10.3390/antiox7030036
55
Hong Yan Li, Yue Liu, Si Leng Hu, Yu Qin Li, Tong Yu Tang. Intestinal Stenosis Related to Immune Checkpoint Inhibitors Caused by Sintilimab: A Case Report. Journal of Inflammation Research 2026;  doi: 10.2147/JIR.S556800
56
Jose Luis Rueda García, Cristina Suárez-Ferrer, Joaquín Poza Cordón, Eduardo Martín-Arranz, María Sánchez Azofra, Laura García Ramírez, Jesús Noci, María Dolores Martín-Arranz. Doppler Activity and Ultrasonographic Detection of Intra-Abdominal Fistulas Are Predictors of Surgery in Crohn’s Disease. Digestive Diseases 2021; 39(3) doi: 10.1159/000511075
57
Jeffrey K. Actor, Keri C. Smith. Translational Inflammation. 2019;  doi: 10.1016/B978-0-12-813832-8.00001-7
58
Wenhui Cui, Liucheng Li, Delin Li, Xiaoting Mo, Wencheng Zhou, Zhihui Zhang, Liang Xu, Ping Zhao, Lianwen Qi, Ping Li, Jian Gao. Total glycosides of Yupingfeng protects against bleomycin-induced pulmonary fibrosis in rats associated with reduced high mobility group box 1 activation and epithelial–mesenchymal transition. Inflammation Research 2015; 64(12) doi: 10.1007/s00011-015-0878-x
59
Francesca Zorzi, Emma Calabrese, Giovanni Monteleone. Pathogenic aspects and therapeutic avenues of intestinal fibrosis in Crohn's disease. Clinical Science 2015; 129(12) doi: 10.1042/CS20150472
60
Shen Jin, Aurelie Cenier, Daniela Wetzel, Bethlehem Arefaine, Mar Moreno-Gonzalez, Marilena Stamouli, Merianne Mohamad, Mariia Lupatsii, Emilio Ríos, Sunjae Lee, Ane Zamalloa, Shilpa Chokshi, Adil Mardinoglu, Saeed Shoaie, Naiara Beraza, Vishal C. Patel, Melanie Schirmer. Microbial collagenase activity is linked to oral–gut translocation in advanced chronic liver disease. Nature Microbiology 2025; 11(1) doi: 10.1038/s41564-025-02223-0
61
Miguel R Ferreira, Ann Muls, David P Dearnaley, H Jervoise N Andreyev. Microbiota and radiation-induced bowel toxicity: lessons from inflammatory bowel disease for the radiation oncologist. The Lancet Oncology 2014; 15(3) doi: 10.1016/S1470-2045(13)70504-7
62
Michael Scharl. Fibrostenotic Inflammatory Bowel Disease. 2018;  doi: 10.1007/978-3-319-90578-5_21
63
Adrienne Breland, Se Eun Ha, Brian G. Jorgensen, Byungchang Jin, Treg A. Gardner, Kenton M. Sanders, Seungil Ro. Smooth Muscle Transcriptome Browser: offering genome-wide references and expression profiles of transcripts expressed in intestinal SMC, ICC, and PDGFRα+ cells. Scientific Reports 2019; 9(1) doi: 10.1038/s41598-018-36607-6
64
Vanessa D’Antongiovanni, Cristina Segnani, Chiara Ippolito, Luca Antonioli, Rocchina Colucci, Matteo Fornai, Nunzia Bernardini, Carolina Pellegrini. Pathological Remodeling of the Gut Barrier as a Prodromal Event of High-Fat Diet-Induced Obesity. Laboratory Investigation 2023; 103(10) doi: 10.1016/j.labinv.2023.100194
65
Patrycja Dudek, Renata Talar-Wojnarowska. Current Approach to Risk Factors and Biomarkers of Intestinal Fibrosis in Inflammatory Bowel Disease. Medicina 2024; 60(2) doi: 10.3390/medicina60020305
66
Stefano Fusco, Juliette Nesseler, Lisa Minn, Sabrina Groß, Nisar P. Malek, Christoph R. Werner. Phenotypic Heterogeneity in Crohn’s Disease-Associated Intestinal Strictures: An Exploratory Retrospective Cohort Study. Diagnostics 2026; 16(12) doi: 10.3390/diagnostics16121841
67
Young Lo, Jean Philippe Sauve, Susan C. Menzies, Theodore S. Steiner, Laura M. Sly. Phosphatidylinositol 3-kinase p110δ drives intestinal fibrosis in SHIP deficiency. Mucosal Immunology 2019; 12(5) doi: 10.1038/s41385-019-0191-z
68
Calen A. Steiner, Peter D. R. Higgins. Fibrostenotic Inflammatory Bowel Disease. 2018;  doi: 10.1007/978-3-319-90578-5_23
69
Fangmei Ling, Yidong Chen, Junrong Li, Mingyang Xu, Gengqing Song, Lei Tu, Huan Wang, Shuang Li, Liangru Zhu. Estrogen Receptor β Activation Mitigates Colitis-associated Intestinal Fibrosis via Inhibition of TGF-β/Smad and TLR4/MyD88/NF-κB Signaling Pathways. Inflammatory Bowel Diseases 2025; 31(1) doi: 10.1093/ibd/izae156
70
Irene Mignini, Valentina Blasi, Fabrizio Termite, Giorgio Esposto, Raffaele Borriello, Lucrezia Laterza, Franco Scaldaferri, Maria Elena Ainora, Antonio Gasbarrini, Maria Assunta Zocco. Fibrostenosing Crohn’s Disease: Pathogenetic Mechanisms and New Therapeutic Horizons. International Journal of Molecular Sciences 2024; 25(12) doi: 10.3390/ijms25126326
71
Beatriz Pinto da Costa, Ana Cristina Gonçalves, Ana Margarida Abrantes, Paulo Matafome, Raquel Seiça, Ana Bela Sarmento-Ribeiro, Maria Filomena Botelho, Francisco Castro-Sousa. Intestinal inflammatory and redox responses to the perioperative administration of teduglutide in rats. Acta Cirurgica Brasileira 2017; 32(8) doi: 10.1590/s0102-865020170080000007
72
Nadila Haryani Osman, Ruhi Fadzlyana Jailani, Hayati Abd Rahman, Nazefah Abdul Hamid. Gene and protein expression of epithelial to mesenchymal transition for intestinal and anal fistula: a systematic review. Annals of Coloproctology 2023; 39(2) doi: 10.3393/ac.2021.00584.0083
73
Xueyong Xie, Yaohui Wang, Bo Deng, Michael R Blatchley, Dongwei Lan, Yizhou Xie, Meng Lei, Na Liu, Feng Xu, Zhao Wei. Matrix metalloproteinase-responsive hydrogels with tunable retention for on-demand therapy of inflammatory bowel disease. Acta Biomaterialia 2024; 186 doi: 10.1016/j.actbio.2024.07.054
74
Weiyan Xiong, Hamdi A. Jama, Bernadine M. Flanagan, Alex Peh, Simona Antonacci, Chudan Xu, Sushil Dhital, Francine Z. Marques. The effect of resistant starch type 1, delivered as intact chickpea cells, on intestinal health and blood pressure. Food Hydrocolloids 2026; 172 doi: 10.1016/j.foodhyd.2025.111878
75
Inge Jacobs, Matthias Ceulemans, Lucas Wauters, Christine Breynaert, Séverine Vermeire, Bram Verstockt, Tim Vanuytsel. Role of Eosinophils in Intestinal Inflammation and Fibrosis in Inflammatory Bowel Disease: An Overlooked Villain?. Frontiers in Immunology 2021; 12 doi: 10.3389/fimmu.2021.754413
76
Sara Mohater, Samar Qahtan, Zienab Alrefaie, Ahlam Alahmadi. Vitamin D improves hepatic alterations in ACE1 and ACE2 expression in experimentally induced metabolic syndrome. Saudi Pharmaceutical Journal 2023; 31(9) doi: 10.1016/j.jsps.2023.101709
77
Lin Hai Kurahara, Keizo Hiraishi, Yaopeng Hu, Kaori Koga, Miki Onitsuka, Mayumi Doi, Kunihiko Aoyagi, Hidetoshi Takedatsu, Daibo Kojima, Yoshitaka Fujihara, Yuwen Jian, Ryuji Inoue. Activation of Myofibroblast TRPA1 by Steroids and Pirfenidone Ameliorates Fibrosis in Experimental Crohn's Disease. Cellular and Molecular Gastroenterology and Hepatology 2018; 5(3) doi: 10.1016/j.jcmgh.2017.12.005
78
Naoki Takemura, Yosuke Kurashima, Yuki Mori, Kazuki Okada, Takayuki Ogino, Hideki Osawa, Hirosih Matsuno, Lamichhane Aayam, Satoshi Kaneto, Eun Jeong Park, Shintaro Sato, Kouta Matsunaga, Yusuke Tamura, Yasuo Ouchi, Yutaro Kumagai, Daichi Kobayashi, Yutaka Suzuki, Yoshichika Yoshioka, Junichi Nishimura, Masaki Mori, Ken J. Ishii, Mark E. Rothenberg, Hiroshi Kiyono, Shizuo Akira, Satoshi Uematsu. Eosinophil depletion suppresses radiation-induced small intestinal fibrosis. Science Translational Medicine 2018; 10(429) doi: 10.1126/scitranslmed.aan0333
79
Ramkumar Mathur, Mahabub Maraj Alam, Xiao-Feng Zhao, Yunfei Huang, Xinjun Zhu. Mechanistic Insight into the Development of TNBS-Mediated Intestinal Fibrosis and Evaluating the Inhibitory Effects of Rapamycin. Journal of Visualized Experiments 2019; (151) doi: 10.3791/60067
80
Hongyan Diao, Guangying Cui, Jianing Chen, Yingfeng Wei. Infectious Microecology. Advanced Topics in Science and Technology in China 2014;  doi: 10.1007/978-3-662-43883-1_3
81
Jiannan Li, Ren Mao, Satya Kurada, Jie Wang, Sinan Lin, Jyotsna Chandra, Florian Rieder. Pathogenesis of fibrostenosing Crohn's disease. Translational Research 2019; 209 doi: 10.1016/j.trsl.2019.03.005
82
Yvonne Hagenlocher, Sabrina Satzinger, Mehtap Civelek, Katharina Feilhauer, Jörg Köninger, Stephan C. Bischoff, Axel Lorentz. Cinnamon reduces inflammatory response in intestinal fibroblasts in vitro and in colitis in vivo leading to decreased fibrosis. Molecular Nutrition & Food Research 2017; 61(9) doi: 10.1002/mnfr.201601085
83
Yunqing Zeng, Jinhou Li, Yuan Zheng, Di Zhang, Ning Zhong, Xiuli Zuo, Yanqing Li, Wenbin Yu, Jiaoyang Lu. Development and validation of a predictive model for submucosal fibrosis in patients with early gastric cancer undergoing endoscopic submucosal dissection: experience from a large tertiary center. Annals of Medicine 2024; 56(1) doi: 10.1080/07853890.2024.2391536
84
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