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For: He W, Li LX, Liao QJ, Liu CL, Chen XL. Epigallocatechin gallate inhibits HBV DNA synthesis in a viral replication - inducible cell line. World J Gastroenterol 2011; 17(11): 1507-1514 [PMID: 21472112 DOI: 10.3748/wjg.v17.i11.1507]
URL: https://www.wjgnet.com/1007-9327/full/v17/i11/1507.htm
Number Citing Articles
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Mohammad K. Parvez, Mohammed S. Al-Dosari, Ahmed H. Arbab, Adnan J. Al-Rehaily, Mazin A.S. Abdelwahid. Bioassay-guided isolation of anti-hepatitis B virus flavonoid myricetin-3-O-rhamnoside along with quercetin from Guiera senegalensis leaves. Saudi Pharmaceutical Journal 2020; 28(5) doi: 10.1016/j.jsps.2020.03.006
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Emmanuelle V. LeBlanc, Che C. Colpitts. The green tea catechin EGCG provides proof-of-concept for a pan-coronavirus attachment inhibitor. Scientific Reports 2022; 12(1) doi: 10.1038/s41598-022-17088-0
4
An-Qi Zhuang, Yan Chen, Shan-Mei Chen, Wen-Cheng Liu, Yao Li, Wen-Jie Zhang, Yi-Hang Wu. Current Status and Challenges in Anti-Hepatitis B Virus Agents Based on Inactivation/Inhibition or Elimination of Hepatitis B Virus Covalently Closed Circular DNA. Viruses 2023; 15(12) doi: 10.3390/v15122315
5
Emile Levy, Edgard Delvin, Valérie Marcil, Schohraya Spahis. Can phytotherapy with polyphenols serve as a powerful approach for the prevention and therapy tool of novel coronavirus disease 2019 (COVID-19)?. American Journal of Physiology-Endocrinology and Metabolism 2020; 319(4) doi: 10.1152/ajpendo.00298.2020
6
Vanessa Loaiza-Cano, Laura Milena Monsalve-Escudero, Carlos da Silva Maia Bezerra Filho, Marlen Martinez-Gutierrez, Damião Pergentino de Sousa. Antiviral Role of Phenolic Compounds against Dengue Virus: A Review. Biomolecules 2020; 11(1) doi: 10.3390/biom11010011
7
Malihe Naderi, Zahra Salavatiha, Urvashee Gogoi, Alireza Mohebbi. An overview of anti-Hepatitis B virus flavonoids and their mechanisms of action. Frontiers in Cellular and Infection Microbiology 2024; 14 doi: 10.3389/fcimb.2024.1356003
8
Aleksandra Kozłowska, Dorota Szostak-Węgierek. Bioactive Molecules in Food. Reference Series in Phytochemistry 2019;  doi: 10.1007/978-3-319-78030-6_54
9
Jun Xu, Zhao Xu, Wenming Zheng. A Review of the Antiviral Role of Green Tea Catechins. Molecules 2017; 22(8) doi: 10.3390/molecules22081337
10
Imen Souid, Atef Korchef, Safouan Souid. In silico evaluation of Vitis amurensis Rupr. Polyphenol compounds for their inhibition potency against COVID-19 main enzymes Mpro and RdRp. Saudi Pharmaceutical Journal 2022; 30(5) doi: 10.1016/j.jsps.2022.02.014
11
Syed Lal Badshah, Shah Faisal, Akhtar Muhammad, Benjamin Gabriel Poulson, Abdul Hamid Emwas, Mariusz Jaremko. Antiviral activities of flavonoids. Biomedicine & Pharmacotherapy 2021; 140 doi: 10.1016/j.biopha.2021.111596
12
Sabrina Bimonte, Cira Antonietta Forte, Massimiliano Cuomo, Gennaro Esposito, Marco Cascella, Arturo Cuomo. An Overview on the Potential Roles of EGCG in the Treatment of COVID-19 Infection. Drug Design, Development and Therapy 2021;  doi: 10.2147/DDDT.S314666
13
Paweł Bakun, Dariusz T. Mlynarczyk, Tomasz Koczorowski, Magdalena Cerbin-Koczorowska, Ludwika Piwowarczyk, Emil Kolasiński, Maciej Stawny, Joanna Kuźmińska, Anna Jelińska, Tomasz Goslinski. Tea-break with epigallocatechin gallate derivatives – Powerful polyphenols of great potential for medicine. European Journal of Medicinal Chemistry 2023; 261 doi: 10.1016/j.ejmech.2023.115820
14
Abdulrahman Hatawsh, Roya Hadi Al-Haddad, Ukamaka Gladys Okafor, Lamis M. Diab, Nino Dekanoidze, Adeniyi Ayinde Abdulwahab, Osama A. Mohammed, Ahmed S. Doghish, Rewan Moussa, Hanan Elimam. Mitoepigenetics pathways and natural compounds: a dual approach to combatting hepatocellular carcinoma. Medical Oncology 2024; 41(12) doi: 10.1007/s12032-024-02538-8
15
L. Bartosikova, J. Necas. Epigallocatechin gallate: a review. Veterinární medicína 2018; 63(10) doi: 10.17221/31/2018-VETMED
16
Zainab Manzoor, Amara Sajad, Syed Shariq Nazir Qadiri, Feroz Ahmad Shah, Shabir Ahmad Dar, Shahid Manzoor Mandu. Polyphenols as antiviral agents: Assessing their potential usage and benefits in aquaculture. Aquaculture International 2025; 33(2) doi: 10.1007/s10499-024-01778-9
17
Li‐Peng Qiu, Liang Chen, Ke‐Ping Chen. Antihepatitis B therapy: a review of current medications and novel small molecule inhibitors. Fundamental & Clinical Pharmacology 2014; 28(4) doi: 10.1111/fcp.12053
18
Surendra Kumar Shukla, Vijay Kumar. Dietary Interventions in Liver Disease. 2019;  doi: 10.1016/B978-0-12-814466-4.00006-9
19
Salima Lalani, Chit Laa Poh. Flavonoids as Antiviral Agents for Enterovirus A71 (EV-A71). Viruses 2020; 12(2) doi: 10.3390/v12020184
20
Edeildo Ferreira da Silva-Júnior, Leandro Rocha Silva. Multi-target Approaches of Epigallocatechin-3-O-gallate (EGCG) and its Derivatives against Influenza Viruses. Current Topics in Medicinal Chemistry 2022; 22(18) doi: 10.2174/1568026622666220127112056
21
Hovakim Zakaryan, Erik Arabyan, Adrian Oo, Keivan Zandi. Flavonoids: promising natural compounds against viral infections. Archives of Virology 2017; 162(9) doi: 10.1007/s00705-017-3417-y
22
Yi-Hang Wu, Yan Chen, An-Qi Zhuang, Shan-Mei Chen. Antiviral Strategies in the Treatment of Human and Animal Viral Infections. Infectious Diseases 2023; 27 doi: 10.5772/intechopen.112221
23
Zijuan Zhao, Meiyan Feng, Juan Wan, Xin Zheng, Cuiqin Teng, Xinya Xie, Wenjing Pan, Baozhu Hu, Jianan Huang, Zhonghua Liu, Jianhua Wu, Shuxian Cai. Research progress of epigallocatechin-3-gallate (EGCG) on anti-pathogenic microbes and immune regulation activities. Food & Function 2021; 12(20) doi: 10.1039/D1FO01352A
24
Ozge Yilmaz, Alev Onder. The Role of Epigallocatechin Gallate (EGCG) in Treatment and Management of Sexually Transmitted Viral Infections. Infectious Disorders - Drug Targets 2025; 25(4) doi: 10.2174/0118715265319110240916061200
25
Chunlan Liu, Dawei Cai, Lin Zhang, Wei Tang, Ran Yan, Haitao Guo, Xulin Chen. Identification of hydrolyzable tannins (punicalagin, punicalin and geraniin) as novel inhibitors of hepatitis B virus covalently closed circular DNA. Antiviral Research 2016; 134 doi: 10.1016/j.antiviral.2016.08.026
26
Aleksandra Kozłowska, Dorota Szostak-Węgierek. Sweeteners. Reference Series in Phytochemistry 2018;  doi: 10.1007/978-3-319-54528-8_54-1
27
Kunihiro Kaihatsu, Miyuki Yamabe, Yasuhito Ebara. Antiviral Mechanism of Action of Epigallocatechin-3-O-gallate and Its Fatty Acid Esters. Molecules 2018; 23(10) doi: 10.3390/molecules23102475
28
Aline de Oliveira, Sandra D. Adams, Lee H. Lee, Sean R. Murray, Stephen D. Hsu, Jeffrey R. Hammond, Douglas Dickinson, Ping Chen, Tin-Chun Chu. Inhibition of herpes simplex virus type 1 with the modified green tea polyphenol palmitoyl-epigallocatechin gallate. Food and Chemical Toxicology 2013; 52 doi: 10.1016/j.fct.2012.11.006
29
Murat Karamese, Sabiha Aydogdu, Selina Aksak Karamese, Ulku Altoparlak, Cemal Gundogdu. Preventive Effects of a Major Component of Green Tea, Epigallocathechin-3-Gallate, on Hepatitis-B Virus DNA Replication. Asian Pacific Journal of Cancer Prevention 2015; 16(10) doi: 10.7314/APJCP.2015.16.10.4199
30
Ming-Xue Li, Yue-Ying Yang, Yang Liu, Meng-Zhu Zheng, Jun Li, Li-Xia Chen, Hua Li. Progress of Traditional Chinese Medicine Treating COVID-19. World Journal of Traditional Chinese Medicine 2021; 7(2) doi: 10.4103/wjtcm.wjtcm_68_20
31
Che C. Colpitts, Luis M. Schang, L. Hutt-Fletcher. A Small Molecule Inhibits Virion Attachment to Heparan Sulfate- or Sialic Acid-Containing Glycans. Journal of Virology 2014; 88(14) doi: 10.1128/JVI.00896-14
32
Sumit Bansal, Shivani Choudhary, Manu Sharma, Suthar Sharad Kumar, Sandeep Lohan, Varun Bhardwaj, Navneet Syan, Saras Jyoti. Tea: A native source of antimicrobial agents. Food Research International 2013; 53(2) doi: 10.1016/j.foodres.2013.01.032
33
受基 龚. Determination of Flavonoids and Anti-Heptitis B Virus Activity of Extracts from Lysimachia fortunei Maxim. Hans Journal of Food and Nutrition Science 2020; 9(01) doi: 10.12677/HJFNS.2020.91012
34
Jae-Min Song. Anti-infective potential of catechins and their derivatives against viral hepatitis. Clinical and Experimental Vaccine Research 2018; 7(1) doi: 10.7774/cevr.2018.7.1.37
35
Salvatore Chirumbolo. Baicalin in flavocoxid may act against hepatitis B virus via a pro-inflammatory pathway. Inflammation Research 2018; 67(3) doi: 10.1007/s00011-017-1111-x
36
Kishor Pant, Ajay K. Yadav, Parul Gupta, Abhishek Singh Rathore, Baibaswata Nayak, Senthil K. Venugopal. Humic acid inhibits HBV-induced autophagosome formation and induces apoptosis in HBV-transfected Hep G2 cells. Scientific Reports 2016; 6(1) doi: 10.1038/srep34496
37
Changchao Huan, Weiyin Xu, Bo Ni, Tingting Guo, Haochun Pan, Luyao Jiang, Lin Li, Jingting Yao, Song Gao. Epigallocatechin-3-Gallate, the Main Polyphenol in Green Tea, Inhibits Porcine Epidemic Diarrhea Virus In Vitro. Frontiers in Pharmacology 2021; 12 doi: 10.3389/fphar.2021.628526
38
Ryosuke Matsuura, Arisa Kawamura, Yasunobu Matsumoto, Yoshiki Iida, Masanori Kanayama, Masahiko Kurokawa, Yoko Aida. Epigallocatechin Gallate Stabilized by Cyclodextrin Inactivates Influenza Virus and Human Coronavirus 229E. Microorganisms 2022; 10(9) doi: 10.3390/microorganisms10091796
39
J Steinmann, J Buer, T Pietschmann, E Steinmann. Anti‐infective properties of epigallocatechin‐3‐gallate (EGCG), a component of green tea. British Journal of Pharmacology 2013; 168(5) doi: 10.1111/bph.12009
40
Mohamad Hesam Shahrajabian, Wenli Sun. Importance of Thymoquinone, Sulforaphane, Phloretin, and Epigallocatechin and their Health Benefits. Letters in Drug Design & Discovery 2024; 21(2) doi: 10.2174/1570180819666220902115521
41
Da Hyun Kim, Jae Hwan Kim, Da Hyun Kim, Jay-Young Jo, Sanguine Byun. Functional foods with antiviral activity. Food Science and Biotechnology 2022; 31(5) doi: 10.1007/s10068-022-01073-4
42
Arpita Roy, Madhura Roy, Amel Gacem, Shreeja Datta, Md. Zeyaullah, Khursheed Muzammil, Thoraya A. Farghaly, Magda H. Abdellattif, Krishna Kumar Yadav, Jesus Simal-Gandara. Role of bioactive compounds in the treatment of hepatitis: A review. Frontiers in Pharmacology 2022; 13 doi: 10.3389/fphar.2022.1051751
43
Fang Zhou, Sengwen Deng, Yong Luo, Zhonghua Liu, Changwei Liu. Research Progress on the Protective Effect of Green Tea Polyphenol (-)-Epigallocatechin-3-Gallate (EGCG) on the Liver. Nutrients 2025; 17(7) doi: 10.3390/nu17071101
44
Saana Soppela, Zlatka Plavec, Stina Gröhn, Iiris Mustonen, Minne Jartti, Sami Oikarinen, Mira Laajala, Varpu Marjomäki, Sarah J. Butcher, Minna M. Hankaniemi. Immunological and structural evaluation of the intranasally administrated CVB1 whole-virus and VLP vaccines. Scientific Reports 2025; 15(1) doi: 10.1038/s41598-025-94656-0
45
Yuling Yang, Di Yang, Yuxuan Yang, Zhe Wang, Lianhui Li, Maolong Wang, Jiayi Xu, Bingqiang Zhang, Lin Hou, Zibin Tian, Ning Li. Epigallocatechin-3-gallate suppresses Hepatitis B virus replication through activating the AMPK/TFEB pathway to promote autophagic degradation of viral core protein. Chinese Journal of Natural Medicines 2026; 24(3) doi: 10.1016/S1875-5364(26)61105-3
46
L Zhong, J Hu, W Shu, B Gao, S Xiong. Epigallocatechin-3-gallate opposes HBV-induced incomplete autophagy by enhancing lysosomal acidification, which is unfavorable for HBV replication. Cell Death & Disease 2015; 6(5) doi: 10.1038/cddis.2015.136
47
Dong Joo Seo, Changsun Choi. Polyphenols: Prevention and Treatment of Human Disease. 2018;  doi: 10.1016/B978-0-12-813008-7.00025-4
48
Neeru Dhamija, AnitaGarg Mangla. Plant Secondary Metabolites. 2022;  doi: 10.1007/978-981-16-4779-6_15
49
Sandra Ciesek, Thomas von Hahn, Che C. Colpitts, Luis M. Schang, Martina Friesland, Jörg Steinmann, Michael P. Manns, Michael Ott, Heiner Wedemeyer, Philip Meuleman, Thomas Pietschmann, Eike Steinmann. The green tea polyphenol, epigallocatechin-3-gallate, inhibits hepatitis C virus entry. Hepatology 2010; 54(6) doi: 10.1002/hep.24610
50
Chao Chen, Hui Qiu, Jian Gong, Qing Liu, Han Xiao, Xin-Wen Chen, Bin-Lian Sun, Rong-Ge Yang. (−)-Epigallocatechin-3-gallate inhibits the replication cycle of hepatitis C virus. Archives of Virology 2012; 157(7) doi: 10.1007/s00705-012-1304-0
51
Katarzyna Chojnacka, Dawid Skrzypczak, Grzegorz Izydorczyk, Katarzyna Mikula, Daniel Szopa, Anna Witek-Krowiak. Antiviral Properties of Polyphenols from Plants. Foods 2021; 10(10) doi: 10.3390/foods10102277
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Lisa Henss, Arne Auste, Christoph Schürmann, Christin Schmidt, Christine von Rhein, Michael D. Mühlebach, Barbara S. Schnierle. The green tea catechin epigallocatechin gallate inhibits SARS-CoV-2 infection.  Journal of General Virology 2021; 102(4) doi: 10.1099/jgv.0.001574
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Markus Burkard, Alban Piotrowsky, Christian Leischner, Katja Detert, Sascha Venturelli, Luigi Marongiu. The Antiviral Activity of Polyphenols. Molecular Nutrition & Food Research 2025; 69(15) doi: 10.1002/mnfr.70042
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Ranya Demir, Sümeyye Sarıtaş, Mikhael Bechelany, Sercan Karav. Polyphenols from Byproducts: Their Applications and Health Effects. Antioxidants 2026; 15(1) doi: 10.3390/antiox15010087
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Wei‐Ju Ni, Xiao‐Xue Chen, Shu‐Yun Wei, Lun‐Li Lan, Rui‐Jin Qiu, Yi‐Ping Ling, Dan‐Shui Zhou, Zhi‐Min Wu, Zhong‐Huan Cao, Cui‐Ping Yu, Yu Zeng. Study on the mechanism of active components of Liupao tea on 3CL pro based on HPLC‐DAD fingerprint and molecular docking technique . Journal of Food Biochemistry 2021; 45(5) doi: 10.1111/jfbc.13707
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Jasleen Kaur, Rajvir Kaur, Amarjeet Kaur. Infectious Diseases and Your Health. 2018;  doi: 10.1007/978-981-13-1577-0_16
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Ying-Qi Wang, Qing-Sheng Li, Xin-Qiang Zheng, Jian-Liang Lu, Yue-Rong Liang. Antiviral Effects of Green Tea EGCG and Its Potential Application against COVID-19. Molecules 2021; 26(13) doi: 10.3390/molecules26133962
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Ivan A. Ross. Plant-Based Therapeutics, Volume 1. 2023;  doi: 10.1007/978-3-031-35155-6_2
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Qingjun Kong, Xueyan Ren, LiDan Tu, Xiaodong Zheng, Zhidong Wang, Yuanjiang Pan. The Mechanism of Action of Pterostilbene in Xinjiang Wine Grape Against the Growth ofGeotrichum citri-aurantii. Food Biotechnology 2016; 30(3) doi: 10.1080/08905436.2016.1198705
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Ye Htut Linn, Win Win Ei, Lwin Mon Mon Myint, Khin Maung Lwin. Anti-hepatitis B activities of Myanmar medicinal plants: a narrative review of current evidence. VirusDisease 2021; 32(3) doi: 10.1007/s13337-021-00714-2
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Mohamed Saadh. Epigallocatechin gallate (EGCG) combined with zinc sulfate inhibits Peste des petits ruminants virus entry and replication. Saudi Journal of Biological Sciences 2021; 28(11) doi: 10.1016/j.sjbs.2021.07.035
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Lucia Capasso, Luigi De Masi, Carmina Sirignano, Viviana Maresca, Adriana Basile, Angela Nebbioso, Daniela Rigano, Paola Bontempo. Epigallocatechin Gallate (EGCG): Pharmacological Properties, Biological Activities and Therapeutic Potential. Molecules 2025; 30(3) doi: 10.3390/molecules30030654
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Shreya Das, Arunima Mondal, Jayeeta Samanta, Santanu Chakraborty, Arunima Sengupta. Oxidative Stress and Toxicity in Reproductive Biology and Medicine. Advances in Experimental Medicine and Biology 2022; 1358 doi: 10.1007/978-3-030-89340-8_13
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Fabricio E. Freije García, Sofía C. Bravo, Guadalupe García Liñares. Advancement of Phenolic Acids in Drug Discovery. 2024;  doi: 10.1016/B978-0-443-18538-0.00011-1
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Laura Marín, Elisa M. Miguélez, Claudio J. Villar, Felipe Lombó. Bioavailability of Dietary Polyphenols and Gut Microbiota Metabolism: Antimicrobial Properties. BioMed Research International 2015; 2015 doi: 10.1155/2015/905215
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