| For: |
Wang AY, Lian LH, Jiang YZ, Wu YL, Nan JX. |
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| URL: | https://www.wjgnet.com/1007-9327/full/v16/i3/384.htm |
| Number | Citing Articles |
| 1 |
Cheng-lin Fu, Ying Liu, Jing Leng, Jing Zhang, Yu-fang He, Chen Chen, Zi Wang, Wei Li. Platycodin D protects acetaminophen-induced hepatotoxicity by inhibiting hepatocyte MAPK pathway and apoptosis in C57BL/6J mice. Biomedicine & Pharmacotherapy 2018; 107 doi: 10.1016/j.biopha.2018.08.082
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| 2 |
Karolin Thiel, Wilfried Klingert, Kathrin Klingert, Matthias H Morgalla, Martin U Schuhmann, Pamela Leckie, Yalda Sharifi, Nathan A Davies, Rajiv Jalan, Andreas Peter, Christian Grasshoff, Alfred Königsrainer, Martin Schenk, Christian Thiel. Porcine model characterizing various parameters assessing the outcome after acetaminophen intoxication induced acute liver failure. World Journal of Gastroenterology 2017; 23(9): 1576-1585 doi: 10.3748/wjg.v23.i9.1576
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| 3 |
Li-Hua Lian, Yan-Ling Wu, Ying Wan, Xin Li, Wen-Xue Xie, Ji-Xing Nan. Anti-apoptotic activity of gentiopicroside in d-galactosamine/lipopolysaccharide-induced murine fulminant hepatic failure. Chemico-Biological Interactions 2010; 188(1) doi: 10.1016/j.cbi.2010.06.004
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| 4 |
Mariel R. B. Betto, Lais F. Lazarotto, Tatiane T. N. Watanabe, David Driemeier, Carlos E. Leite, Maria M. Campos. Effects of treatment with enalapril on hepatotoxicity induced by acetaminophen in mice. Naunyn-Schmiedeberg's Archives of Pharmacology 2012; 385(9) doi: 10.1007/s00210-012-0774-7
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| 5 |
Fu-Chao Liu, Hung-Chen Lee, Chia-Chih Liao, Allen H. Li, Huang-Ping Yu. Tropisetron Protects Against Acetaminophen-Induced Liver Injury via Suppressing Hepatic Oxidative Stress and Modulating the Activation of JNK/ERK MAPK Pathways. BioMed Research International 2016; 2016 doi: 10.1155/2016/1952947
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| 6 |
GIOU-TENG YIANG, YUNG-LUNG YU, KO-TING LIN, JEN-NI CHEN, WEI-JUNG CHANG, CHYOU-WEI WEI. Acetaminophen induces JNK/p38 signaling and activates the caspase-9-3-dependent cell death pathway in human mesenchymal stem cells. International Journal of Molecular Medicine 2015; 36(2) doi: 10.3892/ijmm.2015.2254
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| 7 |
Shogo Takahashi, Naoki Tanaka, Srujana Golla, Tatsuki Fukami, Kristopher W. Krausz, Marianne A. Polunas, Blair C. Weig, Yusuke Masuo, Cen Xie, Changtao Jiang, Frank J. Gonzalez. Editor’s Highlight: Farnesoid X Receptor Protects Against Low-Dose Carbon Tetrachloride-Induced Liver Injury Through the Taurocholate-JNK Pathway. Toxicological Sciences 2017; 158(2) doi: 10.1093/toxsci/kfx094
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| 8 |
Hyunseong Kim, Dong June Keum, Jung won Kwak, Hwan-Suck Chung, Hyunsu Bae, Bruno Lomonte. Bee Venom Phospholipase A2 Protects against Acetaminophen-Induced Acute Liver Injury by Modulating Regulatory T Cells and IL-10 in Mice. PLoS ONE 2014; 9(12) doi: 10.1371/journal.pone.0114726
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| 9 |
Longyue Zhou, Shankang Chen, Yuanyi Wei, Yihui Sun, Yifan Yang, Bingqi Lin, Yuhao Li, Chunxia Wang. Glycyrrhizic acid restores the downregulated hepatic ACE2 signaling in the attenuation of mouse steatohepatitis. European Journal of Pharmacology 2024; 967 doi: 10.1016/j.ejphar.2024.176365
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| 10 |
Chien-Ta Wu, Jeng-Shyan Deng, Wen-Chin Huang, Po-Chou Shieh, Mei-Ing Chung, Guan-Jhong Huang. Salvianolic Acid C against Acetaminophen-Induced Acute Liver Injury by Attenuating Inflammation, Oxidative Stress, and Apoptosis through Inhibition of the Keap1/Nrf2/HO-1 Signaling. Oxidative Medicine and Cellular Longevity 2019; 2019 doi: 10.1155/2019/9056845
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| 11 |
Xinxin Tan, Jiajia Gao, Chao Wang. Review on clinical diagnosis, pathogenesis and therapeutic strategies of drug-induced liver injury. Journal of Holistic Integrative Pharmacy 2025; 6(3) doi: 10.1016/j.jhip.2025.09.002
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| 12 |
Ka-Lok Wong, PaulPui-Hay But, Pang-Chui Shaw. Evaluation of seven DNA barcodes for differentiating closely related medicinal Gentiana species and their adulterants. Chinese Medicine 2013; 8(1) doi: 10.1186/1749-8546-8-16
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| 13 |
Kun-Chang Wu, Yu-Ling Ho, Yueh-Hsiung Kuo, Shyh-Shyun Huang, Guan-Jhong Huang, Yuan-Shiun Chang. Hepatoprotective Effect of Ugonin M, A Helminthostachys zeylanica Constituent, on Acetaminophen-Induced Acute Liver Injury in Mice. Molecules 2018; 23(10) doi: 10.3390/molecules23102420
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| 14 |
Nacera Baali, Zahia Belloum, Samiya Baali, Beatrice Chabi, Laurence Pessemesse, Gilles Fouret, Souad Ameddah, Fadila Benayache, Samir Benayache, Christine Feillet-Coudray, Gérard Cabello, Chantal Wrutniak-Cabello. Protective Activity of Total Polyphenols from Genista quadriflora Munby and Teucrium polium geyrii Maire in Acetaminophen-Induced Hepatotoxicity in Rats. Nutrients 2016; 8(4) doi: 10.3390/nu8040193
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| 15 |
Yu Pan, Yan‐Li Zhao, Ji Zhang, Wan‐Yi Li, Yuan‐Zhong Wang. Phytochemistry and Pharmacological Activities of the Genus Gentiana (Gentianaceae). Chemistry & Biodiversity 2016; 13(2) doi: 10.1002/cbdv.201500333
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| 16 |
Xiaowen Tang, Qiaoling Yang, Fan Yang, Junting Gong, Han Han, Li Yang, Zhengtao Wang. Target profiling analyses of bile acids in the evaluation of hepatoprotective effect of gentiopicroside on ANIT-induced cholestatic liver injury in mice. Journal of Ethnopharmacology 2016; 194 doi: 10.1016/j.jep.2016.08.049
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| 17 |
Xiuhong Wu, Shuhan Tang, Yan Jin, Shanshan Wang, Xijun Wang, Masao Hattori, Hailong Zhang, Zhigang Wang. Determination of the metabolic profile of gentianine after oral administration to rats by high performance liquid chromatography/electrospray ionization-trap mass spectrometry. Journal of Chromatography B 2015; 989 doi: 10.1016/j.jchromb.2015.01.007
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| 18 |
C. Delgado-Montemayor, P. Cordero-Pérez, R. Salazar-Aranda, N. Waksman-Minsky. Models of hepatoprotective activity assessment. Medicina Universitaria 2015; 17(69) doi: 10.1016/j.rmu.2015.10.002
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| 19 |
Li-Hua Lian, Xuejun Jin, Yan-Ling Wu, Xing Fu Cai, Jung Joon Lee, Ji-Xing Nan. Hepatoprotective Effects of Sedum sarmentosum on D-Galactosamine/Lipopolysaccharide–Induced Murine Fulminant Hepatic Failure. Journal of Pharmacological Sciences 2010; 114(2) doi: 10.1254/jphs.10045FP
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| 20 |
Gaole Zhang, Yun Li, Wenlong Wei, Jiayuan Li, Haoju Li, Yong Huang, De-an Guo. Metabolomics Combined with Multivariate Statistical Analysis for Screening of Chemical Markers between Gentiana scabra and Gentiana rigescens. Molecules 2020; 25(5) doi: 10.3390/molecules25051228
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| 21 |
Devaraj Ezhilarasan, Muthusethupathi Sharmila. Mitogen-activated protein kinase signaling and drug-induced liver injury: A molecular connection. Hepatobiliary & Pancreatic Diseases International 2026; doi: 10.1016/j.hbpd.2026.08.009
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| 22 |
The protective effects of total saponins from Ornithogalum saundersiae (Liliaceae) on acute hepatic failure induced by lipopolysaccharide and d-galactosamine in mice. Journal of Ethnopharmacology 2010; 132(2) doi: 10.1016/j.jep.2010.08.025
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| 23 |
Hartmut Jaeschke, Luqi Duan, Jephte Y. Akakpo, Anwar Farhood, Anup Ramachandran. The role of apoptosis in acetaminophen hepatotoxicity. Food and Chemical Toxicology 2018; 118 doi: 10.1016/j.fct.2018.06.025
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| 24 |
Tsai‑Kun Wu, Hsiao‑Chun Liu, Shu‑Yu Lin, Yung‑Luen Yu, Chyou‑Wei Wei. Extracts from guava fruit protect renal tubular endothelial cells against acetaminophen‑induced cytotoxicity. Molecular Medicine Reports 2018; doi: 10.3892/mmr.2018.8529
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| 25 |
Mylanayakanahosahalli Chandrashekar Indumathi, Kamatam Swetha, Kandahalli Venkataranganayaka Abhilasha, Shiva Siddappa, Shivamadhaiah Manjula Kumar, Govinda Keerthi Prasad, Chu-Huang Chen, Gopal Kedihithlu Marathe. Selenium Ameliorates Acetaminophen-Induced Oxidative Stress via MAPK and Nrf2 Pathways in Mice. Biological Trace Element Research 2024; 202(6) doi: 10.1007/s12011-023-03845-3
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| 26 |
Jianping Jiang, Li Yan, Zheng Shi, Lixia Wang, Letian Shan, Thomas Efferth. Hepatoprotective and anti-inflammatory effects of total flavonoids of Qu Zhi Ke (peel of Citrus changshan-huyou) on non-alcoholic fatty liver disease in rats via modulation of NF-κB and MAPKs. Phytomedicine 2019; 64 doi: 10.1016/j.phymed.2019.153082
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| 27 |
Vivek Chowdhary, Kun-yu Teng, Sharda Thakral, Bo Zhang, Cho-hao Lin, Nissar Wani, Lei Bruschweiler-Li, Xiaoli Zhang, Laura James, Dakai Yang, Norman Junge, Rafael Brüschweiler, William M. Lee, Kalpana Ghoshal. miRNA-122 Protects Mice and Human Hepatocytes from Acetaminophen Toxicity by Regulating Cytochrome P450 Family 1 Subfamily A Member 2 and Family 2 Subfamily E Member 1 Expression. The American Journal of Pathology 2017; 187(12) doi: 10.1016/j.ajpath.2017.08.026
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| 28 |
Halil Yaman, Salim Isbilir, Erdinc Cakir, Bulent Uysal. Current issues with paracetamol induced toxicity. Journal of Experimental and Integrative Medicine 2011; 1(3) doi: 10.5455/jeim.010711.ed.005
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| 29 |
Engin Sümer, Gözde Erkanli Senturk, Özlem Unay Demirel, Erdem Yesilada. Comparative biochemical and histopathological evaluations proved that receptacle is the most effective part of Cynara scolymus against liver and kidney damages. Journal of Ethnopharmacology 2020; 249 doi: 10.1016/j.jep.2019.112458
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| 30 |
Wei-shun Tian, Jing Zhao, Myung-Kon Kim, Hyun-Jin Tae, In-Shik Kim, Dongchoon Ahn, Hong Pil Hwang, Ming-xian Mao, Byung-Yong Park. Veronica persica ameliorates acetaminophen-induced murine hepatotoxicity via attenuating oxidative stress and inflammation. Biomedicine & Pharmacotherapy 2023; 169 doi: 10.1016/j.biopha.2023.115898
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| 31 |
James Michael Brown, John G. Ball, Michael Scott Wright, Stephanie Van Meter, Monica A. Valentovic. Novel protective mechanisms for S-adenosyl-l-methionine against acetaminophen hepatotoxicity: Improvement of key antioxidant enzymatic function. Toxicology Letters 2012; 212(3) doi: 10.1016/j.toxlet.2012.05.018
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| 32 |
Yu Liang, Xiangxiao Meng, Zejing Mu, Jun Qian, Baozhong Duan, Li Xu. The complete chloroplast genome and phylogenetic analysis of Gentiana manshurica Kitag from China. Mitochondrial DNA Part B 2020; 5(2) doi: 10.1080/23802359.2020.1745107
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| 33 |
Ali Navid, David M Ng, Benjamin J Stewart, Sergio E Wong, Felice C Lightstone. Quantitative In Silico analysis of transient metabolism of acetaminophen and associated causes of hepatotoxicity in humans. In Silico Pharmacology 2013; 1(1) doi: 10.1186/2193-9616-1-14
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| 34 |
Li-Hua Lian, Ji-Xing Nan. Hepatoprotective traditional herbs with anti-apoptotic activity may reverse liver fibrosis. Chemico-Biological Interactions 2011; 190(2-3) doi: 10.1016/j.cbi.2010.10.012
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| 35 |
İlker Öngüç Aycan, Adnan Tüfek, Orhan Tokgöz, Osman Evliyaoğlu, Uğur Fırat, Gönül Ölmez Kavak, Hüseyin Turgut, Mustafa Uğur Yüksel. Thymoquinone treatment against acetaminophen-induced hepatotoxicity in rats. International Journal of Surgery 2014; 12(3) doi: 10.1016/j.ijsu.2013.12.013
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| 36 |
Han Han, Ai-Zhen Xiong, Chun-Yong He, Qing Liu, Li Yang, Zheng-Tao Wang. Combination of UHPLC/Q-TOF-MS, NMR spectroscopy, and ECD calculation for screening and identification of reactive metabolites of gentiopicroside in humans. Analytical and Bioanalytical Chemistry 2014; 406(6) doi: 10.1007/s00216-013-7572-z
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| 37 |
Zhigang Wang, Shuhan Tang, Yan Jin, Yan Zhang, Masao Hattori, Hailong Zhang, Ning Zhang. Two main metabolites of gentiopicroside detected in rat plasma by LC–TOF-MS following 2,4-dinitrophenylhydrazine derivatization. Journal of Pharmaceutical and Biomedical Analysis 2015; 107 doi: 10.1016/j.jpba.2014.12.003
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| 38 |
Baixin Kou, Yuxin Jiang, Yanan Chen, Jingrong Yang, Jin Sun, Yan Yan, Lili Weng, Chunping Xiao. A Study of Gentianae Radix et Rhizoma Class Differences Based on Chemical Composition and Core Efficacy. Molecules 2023; 28(20) doi: 10.3390/molecules28207132
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| 39 |
Hung-Chen Lee, Chia-Chih Liao, Yuan-Ji Day, Jiin-Tarng Liou, Allen H. Li, Fu-Chao Liu. IL-17 deficiency attenuates acetaminophen-induced hepatotoxicity in mice. Toxicology Letters 2018; 292 doi: 10.1016/j.toxlet.2018.04.021
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| 40 |
Wiktoria Andryszkiewicz, Milena Chmielewska, Julia Ciecierska, Paulina Lenkiewicz, Wiktoria Marciniak, Wiktoria Raczycka, Agata Wojno, Julita Kulbacka, Przemysław Niewiński, Katarzyna Bieżuńska-Kusiak. Gentianaceae Family—Derived Bioactive Compounds—Therapeutic Values and Supporting Role in Inflammation and Detoxification. Nutrients 2025; 17(16) doi: 10.3390/nu17162619
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| 41 |
Shu Li, Qinglan Wang, Yanyan Tao, Chenghai Liu. Swertiamarin Attenuates Experimental Rat Hepatic Fibrosis by Suppressing Angiotensin II–Angiotensin Type 1 Receptor–Extracellular Signal-Regulated Kinase Signaling. The Journal of Pharmacology and Experimental Therapeutics 2016; 359(2) doi: 10.1124/jpet.116.234179
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| 42 |
Daram Yang, Hee-Won Moon, Jong-Won Kim, Bumseok Kim. Pharmacological inhibition of G protein–coupled receptor kinase 2 (GRK2) by paroxetine attenuates acetaminophen-induced hepatotoxicity. The Korean Journal of Physiology & Pharmacology 2026; 30(4) doi: 10.4196/kjpp.25.282
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| 43 |
Wenyan Xie, Chen Chen, Zhihui Jiang, Jian Wang, Matthias F. Melzig, Xiaoying Zhang. Apocynum venetum Attenuates Acetaminophen-Induced Liver Injury in Mice. The American Journal of Chinese Medicine 2015; 43(03) doi: 10.1142/S0192415X15500299
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| 44 |
Chia-Chih Liao, Huang-Ping Yu, An-Hsun Chou, Hung-Chen Lee, Li-Min Hu, Fu-Chao Liu. Gastrodin Alleviates Acetaminophen-Induced Liver Injury in a Mouse Model Through Inhibiting MAPK and Enhancing Nrf2 Pathways. Inflammation 2022; 45(4) doi: 10.1007/s10753-021-01557-1
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| 45 |
Yan-Ming Wang, Min Xu, Dong Wang, Hong-Tao Zhu, Chong-Ren Yang, Ying-Jun Zhang. Review on “Long-Dan”, one of the traditional Chinese medicinal herbs recorded in Chinese pharmacopoeia. Natural Products and Bioprospecting 2012; 2(1) doi: 10.1007/s13659-011-0043-3
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| 46 |
Li-Hua Lian, Yan-Ling Wu, Shun-Zong Song, Ying Wan, Wen-Xue Xie, Xin Li, Ting Bai, Bing-Qing Ouyang, Ji-Xing Nan. Gentiana manshurica Kitagawa Reverses Acute Alcohol-Induced Liver Steatosis through Blocking Sterol Regulatory Element-Binding Protein-1 Maturation. Journal of Agricultural and Food Chemistry 2010; 58(24) doi: 10.1021/jf103976y
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| 47 |
Alaaeldin Ahmed Hamza, Mona Gamel, Ali Abdalla, Youssef Abdalla, Amr Amin. Gentiana lutea attenuates hepatotoxicity induced by ketoconazole in rats by fortifying the cellular antioxidant defense system. The Journal of Basic and Applied Zoology 2023; 84(1) doi: 10.1186/s41936-022-00321-7
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| 48 |
Awais Wahab, Jian-Xin Chen, Cai-Xia Jia, Ghulam Murtaza, Chuan-Hong Wu, Na Wang. Molecular Docking-Based Research on the Potential Anti-Encephalopathy Effect of Gentianine. World Journal of Traditional Chinese Medicine 2021; 7(3) doi: 10.4103/wjtcm.wjtcm_3_21
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| 49 |
Vladimir Mihailović, Jelena Katanić, Danijela Mišić, Vesna Stanković, Mirjana Mihailović, Aleksandra Uskoković, Jelena Arambašić, Slavica Solujić, Milan Mladenović, Nevena Stanković. Hepatoprotective effects of secoiridoid-rich extracts from Gentiana cruciata L. against carbon tetrachloride induced liver damage in rats. Food Funct. 2014; 5(8) doi: 10.1039/C4FO00088A
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| 50 |
Hong-Xu Yang, Yue Shang, Quan Jin, Yan-Ling Wu, Jian Liu, Chun-Ying Qiao, Zi-Ying Zhan, Huan Ye, Ji-Xing Nan, Li-Hua Lian. Gentiopicroside Ameliorates the Progression from Hepatic Steatosis to Fibrosis Induced by Chronic Alcohol Intake. Biomolecules & Therapeutics 2020; 28(4) doi: 10.4062/biomolther.2020.008
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| 51 |
Hartmut Jaeschke, Mitchell R. McGill, C. David Williams, Anup Ramachandran. Current issues with acetaminophen hepatotoxicity—A clinically relevant model to test the efficacy of natural products. Life Sciences 2011; 88(17-18) doi: 10.1016/j.lfs.2011.01.025
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| 52 |
Nahid Azarmehr, Parisa Afshar, Mona Moradi, Heibatollah Sadeghi, Hossein Sadeghi, Behnam Alipoor, Bahman Khalvati, Zahra Barmoudeh, Kazem Abbaszadeh-Goudarzi, Amir Hossein Doustimotlagh. Hepatoprotective and antioxidant activity of watercress extract on acetaminophen-induced hepatotoxicity in rats. Heliyon 2019; 5(7) doi: 10.1016/j.heliyon.2019.e02072
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| 53 |
Kuo Du, Anup Ramachandran, Hartmut Jaeschke. Oxidative stress during acetaminophen hepatotoxicity: Sources, pathophysiological role and therapeutic potential. Redox Biology 2016; 10 doi: 10.1016/j.redox.2016.10.001
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| 54 |
A comprehensive and systemic review of the Gentiana: Ethnobotany, traditional applications, phytochemistry, pharmacology, and toxicology in the Mongolian Plateau. Journal of Ethnopharmacology 2025; 345 doi: 10.1016/j.jep.2025.119573
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| 55 |
Kuan-Hung Lu, Chun-Ting Liu, Rajasekaran Raghu, Lee-Yan Sheen. Therapeutic Potential of Chinese Herbal Medicines in Alcoholic Liver Disease. Journal of Traditional and Complementary Medicine 2012; 2(2) doi: 10.1016/S2225-4110(16)30084-0
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| 56 |
Ngoc Uy Nguyen, Brendan David Stamper. Polyphenols reported to shift APAP-induced changes in MAPK signaling and toxicity outcomes. Chemico-Biological Interactions 2017; 277 doi: 10.1016/j.cbi.2017.09.007
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| 57 |
Vladimir Mihailović, Mirjana Mihailović, Aleksandra Uskoković, Jelena Arambašić, Danijela Mišić, Vesna Stanković, Jelena Katanić, Milan Mladenović, Slavica Solujić, Sanja Matić. Hepatoprotective effects of Gentiana asclepiadea L. extracts against carbon tetrachloride induced liver injury in rats. Food and Chemical Toxicology 2013; 52 doi: 10.1016/j.fct.2012.10.034
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| 58 |
Shanshan Li, Yifa Chen, Ping Fan, Chuanhua Feng, Zhengzheng Liao, Xianzhong Zeng. Lygodium japonicum Herb Ameliorates Nonalcoholic Fatty Liver Disease by Inhibiting Hepatic Lipid Accumulation and Inflammatory Response in ob/ob Mice. ACS Omega 2026; 11(1) doi: 10.1021/acsomega.5c09360
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| 59 |
Min Jiang, Ben-Wen Cui, Yan-Ling Wu, Ji-Xing Nan, Li-Hua Lian. Genus Gentiana: A review on phytochemistry, pharmacology and molecular mechanism. Journal of Ethnopharmacology 2021; 264 doi: 10.1016/j.jep.2020.113391
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| 60 |
An-Hsun Chou, Hung-Chen Lee, Chia-Chih Liao, Huang-Ping Yu, Fu-Chao Liu. ERK/NF-kB/COX-2 Signaling Pathway Plays a Key Role in Curcumin Protection against Acetaminophen-Induced Liver Injury. Life 2023; 13(11) doi: 10.3390/life13112150
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| 61 |
Chia-Chih Liao, Yuan-Ji Day, Hung-Chen Lee, Jiin-Tarng Liou, An-Hsun Chou, Fu-Chao Liu. ERK Signaling Pathway Plays a Key Role in Baicalin Protection Against Acetaminophen-Induced Liver Injury. The American Journal of Chinese Medicine 2017; 45(01) doi: 10.1142/S0192415X17500082
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| 62 |
Fu-Chao Liu, Huang-Ping Yu, Hung-Chen Lee, Chun-Yu Chen, Chia-Chih Liao. The Modulation of Phospho-Extracellular Signal-Regulated Kinase and Phospho-Protein Kinase B Signaling Pathways plus Activity of Macrophage-Stimulating Protein Contribute to the Protective Effect of Stachydrine on Acetaminophen-Induced Liver Injury. International Journal of Molecular Sciences 2024; 25(3) doi: 10.3390/ijms25031484
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| 63 |
Akintunde Jacob Kehinde. Functional Oil from Black Seed Differentially Inhibits Aldose-reductase and Ectonucleotidase Activities by Up-regulating Cellular Energy in Haloperidol-induced Hepatic Toxicity in Rat Liver. Journal of Oleo Science 2017; 66(9) doi: 10.5650/jos.ess17036
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