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For: Jeong DH, Lee GP, Jeong WI, Do SH, Yang HJ, Yuan DW, Park HY, Kim KJ, Jeong KS. Alterations of mast cells and TGF-β1 on the silymarin treatment for CCl4-induced hepatic fibrosis. World J Gastroenterol 2005; 11(8): 1141-1148 [PMID: 15754394 DOI: 10.3748/wjg.v11.i8.1141]
URL: https://www.wjgnet.com/1007-9327/full/v11/i8/1141.htm
Number Citing Articles
1
Mostafa Abass Shalaby, Hossny Awad Elbanna, Salma Mostafa Mohamed, Ghazal A Nabil, Ahmed Hossny Elbanna. In-depth hepatoprotective mechanistic study of Echinacea purpurea flowers: In vitro and in vivo studiesJournal of Herbmed Pharmacology 2021; 11(1): 99 doi: 10.34172/jhp.2022.11
2
Claus Hellerbrand, Jörn M. Schattenberg, Philipp Peterburs, Anja Lechner, Reto Brignoli. The potential of silymarin for the treatment of hepatic disordersClinical Phytoscience 2017; 2(1) doi: 10.1186/s40816-016-0019-2
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Ahmed Fahmy Ahmed, Mona Fouad Mahmoud, Marwa Arafat Ouf, Eman Abd El-Fathaah. Aminoguanidine potentiates the hepatoprotective effect of Silymarin in CCL4 treated ratsAnnals of Hepatology 2011; 10(2): 207 doi: 10.1016/S1665-2681(19)31570-4
4
Yong Kyun Cho, Jung Won Yun, Jung Ho Park, Hong Joo Kim, Dong Il Park, Chong Il Sohn, Woo Kyu Jeon, Byung Ik Kim, Wook Jin, Yong-Hyun Kwon, Mi-Kyung Shin, Tae Moo Yoo, Ju-Hee Kang, Chang-Shin Park. Deleterious effects of silymarin on the expression of genes controlling endothelial nitric oxide synthase activity in carbon tetrachloride-treated rat liversLife Sciences 2009; 85(7-8): 281 doi: 10.1016/j.lfs.2009.06.001
5
CHENG-HSUN YANG, WEI-JEN TING, CHIA-YAO SHEN, HIS-HSIEN HSU, YUEH-MIN LIN, SHENG-HUANG CHANG, FUU-JEN TSAI, VISWANADHA VIJAYA PADMA, CHIH-YANG HUANG, YUHSIN TSAI. SHSST-cyclodextrin complex inhibits TGF-β/Smad3/CTGF to a greater extent than silymarin in a rat model of carbon tetrachloride-induced liver injuryMolecular Medicine Reports 2015; 12(4): 6053 doi: 10.3892/mmr.2015.4190
6
Nageh Ahmed Elmahdy, Samia Salem Sokar, Mohamed Labib Salem, Naglaa Ibrahim Sarhan, Sherin Hamed Abou-Elela. Anti-fibrotic potential of human umbilical cord mononuclear cells and mouse bone marrow cells in CCl4- induced liver fibrosis in miceBiomedicine & Pharmacotherapy 2017; 89: 1378 doi: 10.1016/j.biopha.2017.03.007
7
Naglaa M El-Lakkany, Olfat A Hammam, Walaa H El-Maadawy, Afkar A Badawy, Afaf A Ain-Shoka, Fatma A Ebeid. Anti-inflammatory/anti-fibrotic effects of the hepatoprotective silymarin and the schistosomicide praziquantel against Schistosoma mansoni-induced liver fibrosisParasites & Vectors 2012; 5(1) doi: 10.1186/1756-3305-5-9
8
Pranob Jyoti BHARALİ, Sushanta Kumar BORDOLOİ, Swarnamoni DAS, Kingshuk LAHON. Effect of chronic administration of aqueous extract of Neem (Azadirachta indica) leaves on Paracetamol-induced hepatotoxicity in Wistar albino ratsCurrent Perspectives on Medicinal and Aromatic Plants (CUPMAP) 2022;  doi: 10.38093/cupmap.1167888
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Canine and Feline Liver Cytology2023; : 149 doi: 10.1002/9781119895572.ch8
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Jin Xiao, Hang Liu, Jun Yao, Shuang Yang, Fenglin Shen, KunPeng Bu, Zhenxin Wang, Fan Liu, Ningshao Xia, Quan Yuan, Hong Shu, Yueting Xiong, Xiaohui Liu. The characterization of serum proteomics and metabolomics across the cancer trajectory in chronic hepatitis B‐related liver diseasesVIEW 2024;  doi: 10.1002/VIW.20240031
11
Hale Z Toklu, Ozer Sehirli, Goksel Sener, Melek U Dumlu, Feriha Ercan, Nursal Gedik, Vural Gökmen. Pomegranate peel extract prevents liver fibrosis in biliary-obstructed ratsJournal of Pharmacy and Pharmacology 2007; 59(9): 1287 doi: 10.1211/jpp.59.9.0014
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Omar M. E. Abdel-Salam, Amany A. Sleem, Aliaa E. M. K. El-Mosallamy, Nermeen Shaffie. Effect of Echinacea alone or in combination with silymarin in the carbon-tetrachloride model of hepatotoxicityComparative Clinical Pathology 2012; 21(6): 1483 doi: 10.1007/s00580-011-1317-1
13
Yun-Lian Lin, Chia-Hung Wu, Miao-Hua Luo, Yeh-Jeng Huang, Chuen-Neu Wang, Ming-Shi Shiao, Yi-Tsau Huang. In vitro protective effects of salvianolic acid B on primary hepatocytes and hepatic stellate cellsJournal of Ethnopharmacology 2006; 105(1-2): 215 doi: 10.1016/j.jep.2005.10.021
14
Yun-Kyoung Yim, Hyun Lee, Kwon-Eui Hong, Young-Il Kim, Byung-Ryul Lee, Tae-Han Kim, Ji-Young Yi. Hepatoprotective effect of manual acupuncture at acupoint GB34 against CCl<sub>4</sub>-induced chronic liver damage in ratsWorld Journal of Gastroenterology 2006; 12(14): 2245-2249 doi: 10.3748/wjg.v12.i14.2245
15
Khaled Khazim, Yves Gorin, Rita Cassia Cavaglieri, Hanna E. Abboud, Paolo Fanti. The antioxidant silybin prevents high glucose-induced oxidative stress and podocyte injury in vitro and in vivoAmerican Journal of Physiology-Renal Physiology 2013; 305(5): F691 doi: 10.1152/ajprenal.00028.2013
16
Reem O.A. Kamel. Interactions between mefloquine and the anti-fibrotic drug silymarin onSchistosoma mansoniinfections in miceJournal of Helminthology 2016; 90(6): 760 doi: 10.1017/S0022149X16000018
17
Sherouk Hussein Sweilam, Dalia E. Ali, Ahmed M. Atwa, Ali M. Elgindy, Aya M. Mustafa, Manar M. Esmail, Mahmoud Abdelrahman Alkabbani, Mohamed Magdy Senna, Riham A. El-Shiekh. A First Metabolite Analysis of Norfolk Island Pine Resin and Its Hepatoprotective Potential to Alleviate Methotrexate (MTX)-Induced Hepatic InjuryPharmaceuticals 2024; 17(7): 970 doi: 10.3390/ph17070970
18
Joon-Seok Choi, Jun Ki Kim, Yoon Jung Yang, Yeseul Kim, Pilhan Kim, Sang Gyu Park, Eun-Young Cho, Dae Ho Lee, Jin Woo Choi. Identification of cromolyn sodium as an anti-fibrotic agent targeting both hepatocytes and hepatic stellate cellsPharmacological Research 2015; 102: 176 doi: 10.1016/j.phrs.2015.10.002
19
Nathalie Janel, Christophe Noll. Polyphenols in Human Health and Disease2014; : 665 doi: 10.1016/B978-0-12-398456-2.00051-7
20
Samanta Sifat Lamia, Tushar Emran, Jubaida Khatun Rikta, Nowreen Islam Chowdhury, Manoneeta Sarker, Preeti Jain, Tabinda Islam, Zarin Tasnim Gias, Manik Chandra Shill, Hasan Mahmud Reza. Coenzyme Q10 and Silymarin Reduce CCl4-Induced Oxidative Stress and Liver and Kidney Injury in Ovariectomized Rats—Implications for Protective Therapy in Chronic Liver and Kidney DiseasesPathophysiology 2021; 28(1): 50 doi: 10.3390/pathophysiology28010005
21
Mohammad Kazem Fallahzadeh, Banafshe Dormanesh, Mohammad Mahdi Sagheb, Jamshid Roozbeh, Ghazal Vessal, Maryam Pakfetrat, Yahya Daneshbod, Eskandar Kamali-Sarvestani, Kamran B. Lankarani. Effect of Addition of Silymarin to Renin-Angiotensin System Inhibitors on Proteinuria in Type 2 Diabetic Patients With Overt Nephropathy: A Randomized, Double-Blind, Placebo-Controlled TrialAmerican Journal of Kidney Diseases 2012; 60(6): 896 doi: 10.1053/j.ajkd.2012.06.005
22
P.V. Kiruthiga, R. Beema Shafreen, S. Karutha Pandian, S. Arun, S. Govindu, K. Pandima Devi. Protective effect of silymarin on erythrocyte haemolysate against benzo(a)pyrene and exogenous reactive oxygen species (H2O2) induced oxidative stressChemosphere 2007; 68(8): 1511 doi: 10.1016/j.chemosphere.2007.03.015
23
B. Franceschini, C. Russo, N. Dioguardi, F. Grizzi. Increased liver mast cell recruitment in patients with chronic C virus‐related hepatitis and histologically documented steatosisJournal of Viral Hepatitis 2007; 14(8): 549 doi: 10.1111/j.1365-2893.2007.00859.x
24
Nirmal Kumar Kasinathan, Bharathraja Subramaniya, Niranjali Devaraj Sivasithamparam. NF-κB/twist mediated regulation of colonic inflammation by lupeol in abating dextran sodium sulfate induced colitis in miceJournal of Functional Foods 2018; 41: 240 doi: 10.1016/j.jff.2017.12.048
25
Hale Z. Toklu, Tuba Tunalı-Akbay, Gözde Erkanlı, Meral Yüksel, Feriha Ercan, Göksel Şener. Silymarin, the antioxidant component of Silybum marianum, protects against burn-induced oxidative skin injuryBurns 2007; 33(7): 908 doi: 10.1016/j.burns.2006.10.407
26
Maria Irma Seixas Duarte, Heitor Franco de Andrade, Cleusa Fumica Hirata Takamura, Antonio Sesso, Felipe Francisco Tuon. TGF-beta and mesenchymal hepatic involvement after visceral leishmaniasisParasitology Research 2009; 104(5) doi: 10.1007/s00436-008-1298-4
27
Moon-Jung Goo, Mi-Ran Ki, Hye-Rim Lee, Hai-Jie Yang, Dong-Wei Yuan, Il-Hwa Hong, Jin-Kyu Park, Kyung-Sook Hong, Jung-Youn Han, Ok-Kyung Hwang, Dong-Hwan Kim, Sun-Hee Do, Ronald D Cohn, Kyu-Shik Jeong. Helicobacter pylori promotes hepatic fibrosis in the animal modelLaboratory Investigation 2009; 89(11): 1291 doi: 10.1038/labinvest.2009.90
28
Shaun A. Summers, Poh-yi Gan, Lakshi Dewage, Frank T. Ma, Joshua D. Ooi, Kim M. O'Sullivan, David J. Nikolic-Paterson, A. Richard Kitching, Stephen R. Holdsworth. Mast cell activation and degranulation promotes renal fibrosis in experimental unilateral ureteric obstructionKidney International 2012; 82(6): 676 doi: 10.1038/ki.2012.211
29
Camila Ferreira Bannwart, Erika Nakaira-Takahagi, Marjorie Assis Golim, Leonardo Teixeira Lopes de Medeiros, Mariana Romão, Ingrid Cristina Weel, Maria Terezinha Serrão Peraçoli. Downregulation of nuclear factor-kappa B (NF-κB) pathway by silibinin in human monocytes challenged with Paracoccidioides brasiliensisLife Sciences 2010; 86(23-24): 880 doi: 10.1016/j.lfs.2010.04.005
30
Nadia M. Hamdy, Ebtehal El-Demerdash. New therapeutic aspect for carvedilol: Antifibrotic effects of carvedilol in chronic carbon tetrachloride-induced liver damageToxicology and Applied Pharmacology 2012; 261(3): 292 doi: 10.1016/j.taap.2012.04.012
31
Heather Francis, Cynthia J. Meininger. A review of mast cells and liver disease: What have we learned?Digestive and Liver Disease 2010; 42(8): 529 doi: 10.1016/j.dld.2010.02.016
32
Victor Quinholes Resende, Karoline Hagata Reis-Goes, Angela Carolina Finato, Débora de Fátima Almeida-Donanzam, Amanda Ribeiro dos Santos, Jonatas Perico, Barbara Casella Amorim, James Venturini. Combined Silymarin and Cotrimoxazole Therapy Attenuates Pulmonary Fibrosis in Experimental ParacoccidioidomycosisJournal of Fungi 2022; 8(10): 1010 doi: 10.3390/jof8101010
33
Maria-Angeles Aller, Javier Blanco-Rivero, Natalia Arias, Luis Santamaria, Jaime Arias. The Lymphatic Headmaster of the Mast Cell-Related Splanchnic Inflammation in Portal HypertensionCells 2019; 8(7): 658 doi: 10.3390/cells8070658
34
Kyu‐Shik Jeong. Therapeutic target for chronic liver fibrosis by regulation of transforming growth factor‐betaBasic and Applied Pathology 2008; 1(2): 56 doi: 10.1111/j.1755-9294.2008.00013.x
35
Luminita Voroneanu, Ionut Nistor, Raluca Dumea, Mugurel Apetrii, Adrian Covic. Silymarin in Type 2 Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomized Controlled TrialsJournal of Diabetes Research 2016; 2016: 1 doi: 10.1155/2016/5147468
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Annika Orland, Kirsten Knapp, Gabriele Maria König, Werner Knöss, Gudrun Ulrich-Merzenich. Differential transcriptional profiles in HepG2 cells after the exposure to a chemically characterized complex preparation of Silybi mariani fructus and its chemically defined constituent silybin A+BSynergy 2014; 1(2): 99 doi: 10.1016/j.synres.2014.11.002
37
Nobuyuki Tanahashi, Juri Shikami, Misao Yoneda, Torao Ishida. Effects of Manual Acupuncture at GB34 on Carbon tetrachloride-induced Acute Liver Injury in RatsJournal of Acupuncture and Meridian Studies 2011; 4(4): 214 doi: 10.1016/j.jams.2011.09.012
38
Meng Xu, Kaikun Xu, Shangqi Yin, Cheng Chang, Wei Sun, Guibin Wang, Kai Zhang, Jinsong Mu, Miantao Wu, Baocai Xing, Xiaomei Zhang, Jinyu Han, Xiaohang Zhao, Yajie Wang, Danke Xu, Xiaobo Yu. In-Depth Serum Proteomics Reveals the Trajectory of Hallmarks of Cancer in Hepatitis B Virus–Related Liver DiseasesMolecular & Cellular Proteomics 2023; 22(7): 100574 doi: 10.1016/j.mcpro.2023.100574
39
Cheng-Hsun Yang, Wei-Jen Ting, Cecilia Day, Da-Tong Ju, Yu-Lan Yeh, Li-Chin Chung, Fu-Jenn Tsai, Chang-Hai Tsai, Yuhsin Tsai, Chih-Yang Huang. SHSST Cyclodextrin Complex Prevents the Fibrosis Effect on CCl4-Induced Cirrhotic Cardiomyopathy in Rats through TGF-β Pathway Inhibition EffectsInternational Journal of Molecular Sciences 2014; 15(5): 8037 doi: 10.3390/ijms15058037
40
Gerald W Dryden, Ming Song, Craig McClain. Polyphenols and gastrointestinal diseasesCurrent Opinion in Gastroenterology 2006; 22(2): 165 doi: 10.1097/01.mog.0000208463.69266.8c
41
Doaa I. Mohamed, Enas S. Nabih, Dalia A.A. El-Waseef, Omnyah A. El-Kharashi, Abeer A. Abd El Samad. The protective effect of pentoxifylline versus silymarin on the pancreas through increasing adenosine by CD39 in a rat model of liver cirrhosis: Pharmacological, biochemical and histological studyGene 2018; 651: 9 doi: 10.1016/j.gene.2018.02.001
42
Huizhi Zeng, Yi He, Yang Yu, Jiashu Zhang, Xiaona Zeng, Fengtao Gong, Qi Liu, Bo Yang. Resveratrol improves prostate fibrosis during progression of urinary dysfunction in chronic prostatitis by mast cell suppressionMolecular Medicine Reports 2017;  doi: 10.3892/mmr.2017.7960
43
Edén M. Rodríguez-Flores, Dulce Mata-Espinosa, Jorge Barrios-Payan, Brenda Marquina-Castillo, Mauricio Castañón-Arreola, Rogelio Hernández-Pando, Selvakumar Subbian. A significant therapeutic effect of silymarin administered alone, or in combination with chemotherapy, in experimental pulmonary tuberculosis caused by drug-sensitive or drug-resistant strains: In vitro and in vivo studiesPLOS ONE 2019; 14(5): e0217457 doi: 10.1371/journal.pone.0217457
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Gui-Sheng Li, Wang-Lin Jiang, Jing-Wei Tian, Gui-Wu Qu, Hai-Bo Zhu, Feng-Hua Fu. In vitro and in vivo antifibrotic effects of rosmarinic acid on experimental liver fibrosisPhytomedicine 2010; 17(3-4): 282 doi: 10.1016/j.phymed.2009.05.002
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Carlo Masserdotti. Proportion of mast cells in normal canine hepatic cytologic specimens: comparison of 2 staining methodsVeterinary Clinical Pathology 2013; 42(4): 522 doi: 10.1111/vcp.12086
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Mona M. Ftahy, Noha S. Abdl Latif, Essam F. Alalkamy, Fatma A. El-Batrawi, Ahmad H. Galal, Hany M. Khatab. Antifibrotic potential of a selective COX-2 inhibitor (celecoxib) on liver fibrosis in ratsComparative Clinical Pathology 2013; 22(3): 425 doi: 10.1007/s00580-012-1427-4
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Rumyana Simeonova, Viktor M. Bratkov, Magdalena Kondeva-Burdina, Vessela Vitcheva, Vassil Manov, Ilina Krasteva. Experimental liver protection ofn-butanolic extract ofAstragalus monspessulanusL. on carbon tetrachloride model of toxicity in ratRedox Report 2015; 20(4): 145 doi: 10.1179/1351000214Y.0000000115
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Florent Duval, Jorge E Moreno-Cuevas, María Teresa González-Garza, Carlos Rodríguez-Montalvo, Delia Elva Cruz-Vega. Protective mechanisms of medicinal plants targeting hepatic stellate cell activation and extracellular matrix deposition in liver fibrosisChinese Medicine 2014; 9(1) doi: 10.1186/s13020-014-0027-4
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Bolin Zhao, Kai Liu, Xing Liu, Qiuxia Li, Zhibei Li, Jingjing Xi, Fan Xie, Xiaofang Li. Plant‐derived flavonoids are a potential source of drugs for the treatment of liver fibrosisPhytotherapy Research 2024; 38(6): 3122 doi: 10.1002/ptr.8193
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Baixue Zheng, Looling Tan, Xuejun Mo, Weimiao Yu, Yan Wang, Lisa Tucker-Kellogg, Roy E. Welsch, Peter T. C. So, Hanry Yu, Maria A. Deli. Predicting In Vivo Anti-Hepatofibrotic Drug Efficacy Based on In Vitro High-Content AnalysisPLoS ONE 2011; 6(11): e26230 doi: 10.1371/journal.pone.0026230
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Gu Ningyan, Yao Xu, Shi Hongfei, Chen Jingjing, Chen Min, Abhay R Satoskar. The Role of Macrophage Migration Inhibitory Factor in Mast Cell-Stimulated Fibroblast Proliferation and Collagen ProductionPLOS ONE 2015; 10(3): e0122482 doi: 10.1371/journal.pone.0122482
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Naemat Sandhu, Jennifer Au. Herbal Medicines for the Treatment of Nonalcoholic SteatohepatitisCurrent Hepatology Reports 2021; 20(1): 1 doi: 10.1007/s11901-020-00558-2
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Jing Lu, Baian Chen, Shengli Li, Quan Sun. Tryptase inhibitor APC 366 prevents hepatic fibrosis by inhibiting collagen synthesis induced by tryptase/protease-activated receptor 2 interactions in hepatic stellate cellsInternational Immunopharmacology 2014; 20(2): 352 doi: 10.1016/j.intimp.2014.04.001
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F. F. TUON, M. I. S. DUARTE, V. S. AMATO. A quantitative and morphometric study of mast cells in cutaneous leishmaniasisParasite Immunology 2008; 30(11-12): 641 doi: 10.1111/j.1365-3024.2008.01057.x
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Purificación Corchete. Bioactive Molecules and Medicinal Plants2008; : 123 doi: 10.1007/978-3-540-74603-4_6
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Aysel Kukner, Fatma Tore, Tülin Firat, E. Hakan Terzi, Hakan Oner, Yasemin H Balaban, Candan Ozogul. The preventive effect of low molecular weight heparin on CCL4-induced necrosis and apoptosis in rat liverAnnals of Hepatology 2010; 9(4): 445 doi: 10.1016/S1665-2681(19)31621-7
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Songyan Meng, Fan Yang, Yueqiu Wang, Ying Qin, Huimin Xian, Hui Che, Lihong Wang. Silymarin ameliorates diabetic cardiomyopathy via inhibiting TGF‐β1/Smad signalingCell Biology International 2019; 43(1): 65 doi: 10.1002/cbin.11079
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Carlo Masserdotti, Walter Bertazzolo. Cytologic features of hepatic fibrosis in dogs: a retrospective study on 22 casesVeterinary Clinical Pathology 2016; 45(2): 361 doi: 10.1111/vcp.12352
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Anti‐ and pro‐mutagenic effects of silymarin in the ames bacterial reverse mutation assayPhytotherapy Research 2009; 23(10): 1378 doi: 10.1002/ptr.2772
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Florent Duval, Jorge E. Moreno-Cuevas, María Teresa González-Garza, Carmen Maldonado-Bernal, Delia Elva Cruz-Vega. Liver Fibrosis and Mechanisms of the Protective Action of Medicinal Plants Targeting Inflammation and the Immune ResponseInternational Journal of Inflammation 2015; 2015: 1 doi: 10.1155/2015/943497
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Jia Liu, YiFan Yang, Chao Zheng, Gong Chen, Zhen Shen, Shan Zheng, Rui Dong. Correlation of Interleukin-33/ST2 Receptor and Liver Fibrosis Progression in Biliary Atresia PatientsFrontiers in Pediatrics 2019; 7 doi: 10.3389/fped.2019.00403
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Sang-Wha Lee, Kwang-Mo Yang, Jung-Ki Kim, Byung-Hyouk Nam, Chang-Min Lee, Min-Ho Jeong, Su-Yeong Seo, Gi-Yong Kim, Wol-Soon Jo. Effects of White Radish (Raphanus sativus) Enzyme Extract on HepatotoxicityToxicological Research 2012; 28(3): 165 doi: 10.5487/TR.2012.28.3.165
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Majid Shirani, Roya Raeisi, Saeid Heidari-Soureshjani, Majid Asadi-Samani, Tahra Luther. A review for discovering hepatoprotective herbal drugs with least side effects on kidneyJournal of Nephropharmacology 2017; 6(2): 38 doi: 10.15171/npj.2017.03
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Sina Andalib, Negar Maleki Nejad, Mohammad Kamali Nejad, Mahdi Tavakolizadeh, Maryam Noubarani, Sonia Shahbazi Zanjanmaskan, Mohammad Reza Eskandari. A search for protective activity of aqueous extract of Punica granatum var. pleniflora against CCl4-induced hepatotoxicity in ratsJournal of Medicinal Plants 2020; 19(75): 188 doi: 10.29252/jmp.19.75.188
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Andrea Siegel, Michael D. Wiseman. Cowell and Tyler's Diagnostic Cytology and Hematology of the Dog and Cat2020; : 329 doi: 10.1016/B978-0-323-53314-0.00020-1
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Santosh T. Devkar, Amit D. Kandhare, Anand A. Zanwar, Suresh D. Jagtap, Surendra S. Katyare, Subhash L. Bodhankar, Mahabaleshwar V. Hegde. Hepatoprotective effect of withanolide-rich fraction in acetaminophen-intoxicated rat: decisive role of TNF-α, IL-1β, COX-II and iNOSPharmaceutical Biology 2016; 54(11): 2394 doi: 10.3109/13880209.2016.1157193