BPG is committed to discovery and dissemination of knowledge
Cited by in CrossRef
For: Hegyi P, Jr ZR, Sári R, Góg C, Lonovics J, Takács T, Czakó L. L-arginine-induced experimental pancreatitis. World J Gastroenterol 2004; 10(14): 2003-2009 [PMID: 15237423 DOI: 10.3748/wjg.v10.i14.2003]
URL: https://www.wjgnet.com/1007-9327/full/v10/i14/2003.htm
Number Citing Articles
1
Rajinder Dawra, Rifat Sharif, Phoebe Phillips, Vikas Dudeja, Dhara Dhaulakhandi, Ashok K. Saluja. Development of a new mouse model of acute pancreatitis induced by administration of l-arginine. American Journal of Physiology-Gastrointestinal and Liver Physiology 2007; 292(4) doi: 10.1152/ajpgi.00167.2006
2
Shabir Sidhu, Promila Pandhi, Samir Malhotra, Kim Vaiphei, Kundal Lal Khanduja. Beneficial Effects ofEmblica officinalisinl-Arginine-Induced Acute Pancreatitis in Rats. Journal of Medicinal Food 2011; 14(1-2) doi: 10.1089/jmf.2010.1108
3
Fahaid Al-Hashem. Metformin Ameliorates Infiltration of Inflammatory Cells and Pancreatic Injury Biomarkers Induced by L-Arginine. International Journal of Pharmacology 2022; 18(5) doi: 10.3923/ijp.2022.1038.1046
4
Deeksha Marwari, Anamika Singh, Shreya Pandey, Afzal Azim, Neeraj Sinha. Insights from NMR - based metabolomics elucidates key metabolic dysregulation in pancreatitis-induced acute respiratory distress syndrome: A step towards precision medicine. Biophysical Chemistry 2026; 337 doi: 10.1016/j.bpc.2026.107665
5
Eszter Bohus, Muireann Coen, Hector C. Keun, Timothy M. D. Ebbels, Olaf Beckonert, John C. Lindon, Elaine Holmes, Béla Noszál, Jeremy K. Nicholson. Temporal Metabonomic Modeling ofl-Arginine-Induced Exocrine Pancreatitis. Journal of Proteome Research 2008; 7(10) doi: 10.1021/pr800407j
6
Alexander A Aghdassi, Julia Mayerle, Sandra Christochowitz, Frank U Weiss, Matthias Sendler, Markus M Lerch. Animal models for investigating chronic pancreatitis. Fibrogenesis & Tissue Repair 2011; 4(1) doi: 10.1186/1755-1536-4-26
7
Nikola M Stojanović, Katarina V Mitić, Slavica Stojnev, Dušan Sokolović, Marija Vukelić Nikolić, Dragana Tričković-Vukić, Pavle J Randjelović, Miljan Krstić, Niko S Radulović. Functioning of whole bone marrow cell population in a model of L-arginine-induced pancreatitis. European Journal of Inflammation 2023; 21 doi: 10.1177/1721727X231177816
8
Heba M. Eltahir, Hossein M. Elbadawy, Mohannad A. Almikhlafi, Ali M. Alalawi, Ahmed J. Aldhafiri, Yaser M. Alahmadi, Sultan S. Al thagfan, Muayad Albadrani, Saber M Eweda, Mekky M. Abouzied. Sitagliptin ameliorates L-arginine-induced acute pancreatitis via modulating inflammatory cytokines expression and combating oxidative stress. Frontiers in Pharmacology 2024; 15 doi: 10.3389/fphar.2024.1389670
9
Xiaodong Du, Yu Cao, Ping Xue, Ziqi Lin, Zhi Zeng, Qing Xia. Protective effect of intermedin on myocardial cell in a rat model of severe acute pancreatitis. Cellular and Molecular Biology Letters 2011; 16(3) doi: 10.2478/s11658-011-0020-1
10
Annamaria Szabolcs, Russel J Reiter, Tamas Letoha, Peter Hegyi, Gabor Papai, Ilona Varga, Katalin Jarmay, Jozsef Kaszaki, Reka Sari, Zoltan Rakonczay Jr, Janos Lonovics, Tamas Takacs. Effect of melatonin on the severity of L-arginine-induced experimental acute pancreatitis in rats. World Journal of Gastroenterology 2006; 12(2): 251-258 doi: 10.3748/wjg.v12.i2.251
11
Marlus Moreira, Jorge Eduardo Fouto Matias, Carlos José Franco de Souza, João Eduardo Leal Nicoluzzi, Pedro Ernesto Caron, João Carlos Domingues Repka. Ação do tacrolimus na pancreatite aguda experimental induzida pela arginina. Revista do Colégio Brasileiro de Cirurgiões 2011; 38(4) doi: 10.1590/S0100-69912011000400010
12
Randa A. Zaghloul, Dalia H. El‐Kashef, Medhat Taha, Noha Abdel‐Rahman. Anti‐Inflammatory Effect of Dopamine D2 Receptor Agonist Cabergoline Against L‐Arginine‐Induced Acute Pancreatitis in Rats. Journal of Biochemical and Molecular Toxicology 2025; 39(7) doi: 10.1002/jbt.70370
13
Shabir Sidhu, Promila Pandhi, Samir Malhotra, Kim Vaiphei, K.L. Khanduja. Melatonin treatment is beneficial in pancreatic repair process after experimental acute pancreatitis. European Journal of Pharmacology 2010; 628(1-3) doi: 10.1016/j.ejphar.2009.11.058
14
Stephen J. Pandol, Ashok K. Saluja, Clement W. Imrie, Peter A. Banks. Acute Pancreatitis: Bench to the Bedside. Gastroenterology 2007; 133(3) doi: 10.1053/j.gastro.2007.08.026
15
Evolving paradigm of illnesses presented to medical Intensive Care Unit in body builders: Cases from tertiary care center. Indian Journal of Critical Care Medicine 2015; 19(4) doi: 10.4103/0972-5229.154559
16
Z.А. Gorenko, О.А. Grinchenko, S.P. Veselsky, V.M. Baban. COMPOSITION OF GASTRIC JUICE AND BILE IN RATS AT THE EXPERIMENTAL CHRONIC PANCREATITIS. Fiziolohichnyĭ zhurnal 2015; 61(6) doi: 10.15407/fz61.06.086
17
Kim Hue Su, Christine Cuthbertson, Christopher Christophi. Review of experimental animal models of acute pancreatitis. HPB 2006; 8(4) doi: 10.1080/13651820500467358
18
Shabir Sidhu, Promila Pandhi, Samir Malhotra, Kim Vaiphei, KL Khanduja. Rosiglitazone promotes pancreatic regeneration in experimental model of acute pancreatitis. Fundamental & Clinical Pharmacology 2011; 25(2) doi: 10.1111/j.1472-8206.2010.00827.x
19
Şerife Nur Bulat, Özden Kutlay, Tülay Akan, Fatma Fırat. Phoenixin-14 attenuates pancreatic injury by modulating inflammation, oxidative stress, and apoptosis in L-arginine-induced acute pancreatitis. Peptides 2026; 201 doi: 10.1016/j.peptides.2026.171513
20
Ziqi Lin, Jia Guo, Ping Xue, Lei Huang, Lihui Deng, Xiaonan Yang, Qing Xia. Chaiqinchengqi decoction regulates necrosis-apoptosis via regulating the release of mitochondrial cytochrome c and caspase-3 in rats with acute necrotizing pancreatitis. Journal of Traditional Chinese Medicine 2014; 34(2) doi: 10.1016/S0254-6272(14)60075-3
21
Hadeel A. Fawzy, Asmaa A. Mohammed, Hala M. Fawzy, Ebtehal M. Fikry. Reorienting of pramipexole as a promising therapy for acute pancreatitis in a rat model by suppressing TLR4\NF-κB p65\NLRP3 inflammasome signaling. Canadian Journal of Physiology and Pharmacology 2022; 100(6) doi: 10.1139/cjpp-2021-0664
22
Hongfeng Liu, Lihui Luo, Amol Muthal, Shuangquan Qin. Protective effects of apigenin on experimental biliary acute pancreatitis: Role of Insulin-like growth factor-binding protein 4, G protein-coupled bile acid receptor 1, and G protein-coupled receptor 39.. Investigación Clínica 2026; 67(3) doi: 10.54817/IC.v67n3a02
23
Aleksandra Tarasiuk, Marcin Talar, Kamila Bulak, Jakub Fichna. Ghee Butter from Bovine Colostrum Reduces Inflammation in the Mouse Model of Acute Pancreatitis with Potential Involvement of Free Fatty Acid Receptors. Nutrients 2021; 13(9) doi: 10.3390/nu13093271
24
Huan Yang, ShuCan Ma, Yu Guo, DongLai Cui, JinFeng Yao. Bidirectional Effects of Pyrrolidine Dithiocarbamate on Severe Acute Pancreatitis in a Rat Model. Dose-Response 2019; 17(1) doi: 10.1177/1559325819825905
25
Agnes S. Kowalik, Charis L. Johnson, Sami A. Chadi, Jacqueline Y. Weston, Elena N. Fazio, Christopher L. Pin. Mice lacking the transcription factor Mist1 exhibit an altered stress response and increased sensitivity to caerulein-induced pancreatitis. American Journal of Physiology-Gastrointestinal and Liver Physiology 2007; 292(4) doi: 10.1152/ajpgi.00512.2006
26
Chen-Long Zhang, Zi-Qi Lin, Rui-Jie Luo, Xiao-Xin Zhang, Jia Guo, Wei Wu, Na Shi, Li-Hui Deng, Wei-Wei Chen, Xiao-Ying Zhang, Shameena Bharucha, Wei Huang, Robert Sutton, John A. Windsor, Ping Xue, Qing Xia, Manel Santafe. Chai‐Qin‐Cheng‐Qi Decoction and Carbachol Improve Intestinal Motility by Regulating Protein Kinase C‐Mediated Ca2+ Release in Colonic Smooth Muscle Cells in Rats with Acute Necrotising Pancreatitis. Evidence-Based Complementary and Alternative Medicine 2017; 2017(1) doi: 10.1155/2017/5864945
27
Aleksandra Tarasiuk, Kamila Bulak, Marcin Talar, Jakub Fichna. Chlorogenic acid reduces inflammation in murine model of acute pancreatitis. Pharmacological Reports 2021; 73(5) doi: 10.1007/s43440-021-00320-5
28
Feyzullah Uçmak, Nazım Ekin, İbrahim İbiloğlu, Serkan Arslan, İbrahim Kaplan, Ebubekir Şenateş. Prophylactic Administration of Silybin Ameliorates L-Arginine-Induced Acute Pancreatitis. Medical Science Monitor 2016; 22 doi: 10.12659/MSM.898014
29
Nikola M. Stojanović, Milica Stevanović, Pavle Randjelović, Katarina Mitić, Vladmir Petrović, Dušan Sokolović, Bojan Mladenović, Jelena Lalić, Niko S. Radulović. Low dose of carvacrol prevents rat pancreas tissue damage after L-arginine application, while higher doses cause pancreatic tissue impairment. Food and Chemical Toxicology 2019; 128 doi: 10.1016/j.fct.2019.04.010
30
Prasong Siriviriyakul, Thidarat Chingchit, Naruemon Klaikeaw, Maneerat Chayanupatkul, Duangporn Werawatganon. Effects of curcumin on oxidative stress, inflammation and apoptosis in L-arginine induced acute pancreatitis in mice. Heliyon 2019; 5(8) doi: 10.1016/j.heliyon.2019.e02222
31
Patrick Neuhöfer, Caitlin M. Roake, Stewart J. Kim, Ryan J. Lu, Robert B. West, Gregory W. Charville, Steven E. Artandi. Acinar cell clonal expansion in pancreas homeostasis and carcinogenesis. Nature 2021; 597(7878) doi: 10.1038/s41586-021-03916-2
32
Maisam Abu-El-Haija, Anna S. Gukovskaya, Dana K. Andersen, Timothy B. Gardner, Peter Hegyi, Stephen J. Pandol, Georgios I. Papachristou, Ashok K. Saluja, Vikesh K. Singh, Aliye Uc, Bechien U. Wu. Accelerating the Drug Delivery Pipeline for Acute and Chronic Pancreatitis. Pancreas 2018; 47(10) doi: 10.1097/MPA.0000000000001175
33
Eman H. Eltantaway, Gehan Khalaf, Ghada G. Hamam. Effect of experimentally induced chronic pancreatitis on the structure of hepatocytes and the duodenal villi in adult male albino rats. The Egyptian Journal of Histology 2015; 38(1) doi: 10.1097/01.EHX.0000457300.50130.58
34
Andrea S. Bedrosian, Andrew H. Nguyen, Michael Hackman, Michael K. Connolly, Ashim Malhotra, Junaid Ibrahim, Napoleon E. Cieza–Rubio, Justin R. Henning, Rocky Barilla, Adeel Rehman, H. Leon Pachter, Marco V. Medina–Zea, Steven M. Cohen, Alan B. Frey, Devrim Acehan, George Miller. Dendritic Cells Promote Pancreatic Viability in Mice With Acute Pancreatitis. Gastroenterology 2011; 141(5) doi: 10.1053/j.gastro.2011.07.033
35
Amal Ahmed Abd El-Fattah, Nermin Abdel Hamid Sadik, Ahmad Mustafa Shahin, Nancy Nabil Shahin. Simvastatin and eugenol restore autophagic flux and alleviate oxidative, inflammatory, and fibrotic perturbations in an arginine-induced chronic pancreatitis rat model. Archives of Biochemistry and Biophysics 2025; 768 doi: 10.1016/j.abb.2025.110357
36
A.A. Abd El-Rahman, Emad S. Mishriki, Amal A. Shehab, A.A. Mona. Therapeutic effect of pentoxifylline versus losartan on experimentally induced acute pancreatitis in adult albino rats. The Egyptian Journal of Histology 2011; 34(3) doi: 10.1097/01.EHX.0000401367.91216.9d
37
Thomas Forest, Daniel Holder, Adam Smith, Caron Cunningham, Xiaorui Yao, Markus Dey, Clay Frederick, Srinivasa Prahalada. Characterization of the Exocrine Pancreas in the Male Zucker Diabetic Fatty Rat Model of Type 2 Diabetes Mellitus Following 3 Months of Treatment With Sitagliptin. Endocrinology 2014; 155(3) doi: 10.1210/en.2013-1781
38
Gianfranco Sebastio, Maria P. Sperandeo, Generoso Andria. Lysinuric protein intolerance: Reviewing concepts on a multisystem disease. American Journal of Medical Genetics Part C: Seminars in Medical Genetics 2011; 157(1) doi: 10.1002/ajmg.c.30287
39
Zhiqiang Zhang, Yanqing Wang, Ming Dong, Jianchun Cui, Daqing Rong, Qi Dong. Oxymatrine Ameliorates l-Arginine-Induced Acute Pancreatitis in Rats. Inflammation 2012; 35(2) doi: 10.1007/s10753-011-9352-2
40
Ilya Gukovsky, Aurelia Lugea, Mohammad Shahsahebi, Jason H. Cheng, Peggy P. Hong, Yoon J. Jung, Quing-gao Deng, Barbara A. French, William Lungo, Samuel W. French, Hidekazu Tsukamoto, Stephen J. Pandol.. A rat model reproducing key pathological responses of alcoholic chronic pancreatitis. American Journal of Physiology-Gastrointestinal and Liver Physiology 2008; 294(1) doi: 10.1152/ajpgi.00006.2007
41
Razan Alawaji, Mohamed S. Abdel‐Bakky, Hussein M. Ali, Miad A. Aljuhani, Abdulaziz Arif A. Alshammari, Hashim K. Kamal, Maamoun M. K. Khoja, Kholoud Alsehemi, Mennatallah A. Korani, Eman S. Said. Assessing the therapeutic potential of Tirzepatide in modulating inflammatory responses and mitigating acute pancreatitis. Animal Models and Experimental Medicine 2025; 8(10) doi: 10.1002/ame2.70083
42
Veena Gadicherla, SivaReddy Challa, MandavaV Basaveswara Rao, PavanKumar Kunda, Ramakrishna Prudhvi. Morinda Citrifolia (Noni) fruit protects the exocrine pancreatic dysfunction against L-arginine induced acute pancreatitis in rats. Pharmacognosy Magazine 2019; 15(64) doi: 10.4103/pm.pm_661_18
43
Barry E. Argent, Michael A. Gray, Martin C. Steward, R. Maynard Case. Physiology of the Gastrointestinal Tract. 2006;  doi: 10.1016/B978-012088394-3/50057-X
44
M. Teresa Borrello, Mickenzie B. Martin, Christopher L. Pin. The unfolded protein response: An emerging therapeutic target for pancreatitis and pancreatic ductal adenocarcinoma. Pancreatology 2022; 22(1) doi: 10.1016/j.pan.2021.10.007
45
Marvy G. Mores, Ebtehal Mohammad Fikry, Ahmed O. El-Gendy, Wafaa R. Mohamed, Osama A. Badary. Probiotics mixture and taurine attenuate L-arginine-induced acute pancreatitis in rats: Impact on transient receptor potential vanilloid-1 (TRPV-1)/IL-33/NF-κB signaling and apoptosis. Tissue and Cell 2023; 85 doi: 10.1016/j.tice.2023.102234
46
Quentin Binet, Inès Dufour, Emmanuel Agneessens, Jean-Claude Debongnie, Tarik Aouattah, Angélique Covas, Jean-Charles Coche, Xavier De Koninck. The second case of a young man with l-arginine-induced acute pancreatitis. Clinical Journal of Gastroenterology 2018; 11(5) doi: 10.1007/s12328-018-0862-4
47
Barry E. Argent, Michael A. Gray, Martin C. Steward, R.Maynard Case. Physiology of the Gastrointestinal Tract. 2012;  doi: 10.1016/B978-0-12-382026-6.00051-8
48
Aya Sakai, Shin Nishiumi, Yuuki Shiomi, Takashi Kobayashi, Yoshihiro Izumi, Hiromu Kutsumi, Takanobu Hayakumo, Takeshi Azuma, Masaru Yoshida. Metabolomic analysis to discover candidate therapeutic agents against acute pancreatitis. Archives of Biochemistry and Biophysics 2012; 522(2) doi: 10.1016/j.abb.2012.03.025
49
M Chvanov, O.H Petersen, A Tepikin. Free radicals and the pancreatic acinar cells: role in physiology and pathology. Philosophical Transactions of the Royal Society B: Biological Sciences 2005; 360(1464) doi: 10.1098/rstb.2005.1757
50
Lei Liu, Hanwen Liu, Mengmeng Zhao, Jiliang Wen, Jiaxin Liu, Guangda Lv, Zhiying Xiao, Wenzhen Wang, Shulu Zu, Wendong Sun, Xiulin Zhang, Liping Gong. Functional Upregulation of TRPM3 Channels Contributes to Acute Pancreatitis-associated Pain and Inflammation. Inflammation 2024; 48(3) doi: 10.1007/s10753-024-02138-8
51
Manpreet Uppal, Sudheer Kumar Neredimelli, Harlokesh Narayan Yadav, Rajni Yadav, Sudip Kumar Datta, Soumya Jagannath Mahapatra, Anand Narayan Singh, Tony George Jacob, Pramod Kumar Garg, Peush Sahni. Development of an experimental model of severe acute pancreatitis with organ failure. Pancreatology 2026; 26(3) doi: 10.1016/j.pan.2026.03.008
52
Karin N. Westlund. Animal Models of Pain. Neuromethods 2011; 49 doi: 10.1007/978-1-60761-880-5_3
53
Elizabeth C. Wick, Steven G. Hoge, Sarah W. Grahn, Edward Kim, Lorna A. Divino, Eileen F. Grady, Nigel W. Bunnett, Kimberly S. Kirkwood. Transient receptor potential vanilloid 1, calcitonin gene-related peptide, and substance P mediate nociception in acute pancreatitis. American Journal of Physiology-Gastrointestinal and Liver Physiology 2006; 290(5) doi: 10.1152/ajpgi.00154.2005
54
Archana Karole, Yirivinti Hayagreeva Dinakar, Poonam Sagar, Shabi Parvez, Ravi Kumar, Shyam Lal Mudavath. Targeting inflammatory macrophages with tailored bioactive β-glucan conjugated polymeric nanoparticles for the treatment of pancreatitis. Chemical Engineering Journal 2025; 516 doi: 10.1016/j.cej.2025.163838
55
Stephen J. Pandol, Ashok K. Saluja, Clement W. Imrie, Peter A. Banks. Acute Pancreatitis: Bench to the Bedside. Gastroenterology 2007; 132(3) doi: 10.1053/j.gastro.2007.01.055
56
Nikola M. Stojanović, Katarina V. Mitić, Milica Nešić, Milica Stanković, Vladimir Petrović, Marko Baralić, Pavle J. Randjelović, Dušan Sokolović, Niko Radulović. Oregano (Origanum vulgare) Essential Oil and Its Constituents Prevent Rat Kidney Tissue Injury and Inflammation Induced by a High Dose of L-Arginine. International Journal of Molecular Sciences 2024; 25(2) doi: 10.3390/ijms25020941
57
Murat Yildar, Murat Basbug, Omer FAruk Ozkan, Faruk Cavdar, Ismail Yaman, Hasan Aksit, Musa Ozgur Ozyigit, Figen Aslan, Hayrullah Derici. The effects of 2-aminoethyl diphenylborinate on L-Arginine induced acute pancreatitis in the rats. Medical Science and Discovery 2015; 2(6) doi: 10.36472/msd.v2i6.81
58
Xinmin Yang, Linbo Yao, Xianghui Fu, Rajarshi Mukherjee, Qing Xia, Monika A. Jakubowska, Pawel E. Ferdek, Wei Huang. Experimental Acute Pancreatitis Models: History, Current Status, and Role in Translational Research. Frontiers in Physiology 2020; 11 doi: 10.3389/fphys.2020.614591
59
Elizabeth C. Wick, Stella Pikios, Eileen F. Grady, Kimberly S. Kirkwood. Calcitonin gene–related peptide partially mediates nociception in acute experimental pancreatitis. Surgery 2006; 139(2) doi: 10.1016/j.surg.2005.08.024
60
Ok-Sun Choi, Sung-Joo Park, Sang-Wan Seo, Cheung-Seog Park, Jeong-Je Cho, Hyun-Jong Ahn. The 3-Hydroxy-3-methylglutaryl Coenzyme A (HMG-CoA) Reductase Inhibitor, Lovastatin (Statin) Ameliorates CCK-Induced Acute Pancreatitis in Rats. Biological and Pharmaceutical Bulletin 2005; 28(8) doi: 10.1248/bpb.28.1394
61
Péter Hegyi, Zoltán Rakonczay. The Role of Nitric Oxide in the Physiology and Pathophysiology of the Exocrine Pancreas. Antioxidants & Redox Signaling 2011; 15(10) doi: 10.1089/ars.2011.4063
62
Abdulrahman L. Al-Malki. Suppression of acute pancreatitis by L-lysine in mice. BMC Complementary and Alternative Medicine 2015; 15(1) doi: 10.1186/s12906-015-0729-x
63
Marwa E. Abdelmageed, Manar A. Nader, Marwa S. Zaghloul. Targeting HMGB1/TLR4/NF-κB signaling pathway by protocatechuic acid protects against l-arginine induced acute pancreatitis and multiple organs injury in rats. European Journal of Pharmacology 2021; 906 doi: 10.1016/j.ejphar.2021.174279
64
Simon Sirtl, Mahmood Ahmad, Prince Allawadhi, Thomas Metzler, Oliver Buchstab, Steffen Ormanns, Martina Rudelius, Georg Beyer, Lukasz Krupa, Robert Staron, Christian Schulz, Lisa Fahr, Andrea Sendelhofert, Christian Schulz, Katja Steiger, Matthias Sendler, Markus M. Lerch, Ivonne Regel, Michal Żorniak, Julia Mayerle, Ujjwal M. Mahajan. NLRP3 Inflammasome Activation‐Induced Acute Papillitis as a Trigger of Acute Pancreatitis ‐ A Novel Mechanism of Microlithiasis‐Induced Acute Pancreatitis. United European Gastroenterology Journal 2026; 14(2) doi: 10.1002/ueg2.70198
65
Olga A. Mareninova, Kai-Feng Sung, Peggy Hong, Aurelia Lugea, Stephen J. Pandol, Ilya Gukovsky, Anna S. Gukovskaya. Cell Death in Pancreatitis. Journal of Biological Chemistry 2006; 281(6) doi: 10.1074/jbc.M511276200
66
Mervi T. Hyvönen, Karl-Heinz Herzig, Riitta Sinervirta, Elke Albrecht, Isto Nordback, Juhani Sand, Tuomo A. Keinänen, Jouko Vepsäläinen, Nikolay Grigorenko, Alex R. Khomutov, Burkhard Krüger, Juhani Jänne, Leena Alhonen. Activated Polyamine Catabolism in Acute Pancreatitis. The American Journal of Pathology 2006; 168(1) doi: 10.2353/ajpath.2006.050518
67
Caridad Díaz, Cristina Jiménez-Luna, Carmelo Diéguez-Castillo, Ariadna Martín, José Prados, José Luis Martín-Ruíz, Olga Genilloud, Francisca Vicente, José Pérez del Pérez del Palacio, Octavio Caba. Untargeted Metabolomics for the Diagnosis of Exocrine Pancreatic Insufficiency in Chronic Pancreatitis. Medicina 2021; 57(9) doi: 10.3390/medicina57090876
68
Fahaid Al-Hashem, Mohamed Abd Ellatif, Asmaa M. ShamsEldeen, Samaa S. Kamar, Bahjat Al-Ani, Mohamed A. Haidara. Vitamin E protects against the modulation of TNF-α-AMPK axis and inhibits pancreas injury in a rat model of L-arginine-induced acute necrotising pancreatitis. Archives of Physiology and Biochemistry 2023; 129(1) doi: 10.1080/13813455.2020.1806330
69
Yunan Wang, Abudurexiti Kayoumu, Guotao Lu, Pengfei Xu, Xu Qiu, Liye Chen, Rong Qi, Shouxiong Huang, Weiqin Li, Yuhui Wang, George Liu. Experimental Models in Syrian Golden Hamster Replicate Human Acute Pancreatitis. Scientific Reports 2016; 6(1) doi: 10.1038/srep28014
70
Junyuan Zheng, Zhenlin Tan, Jianyu Wu, Jian Liu, Tao Yang, Hui Yang. Polystyrene microplastics aggravate acute pancreatitis in mice. Toxicology 2023; 491 doi: 10.1016/j.tox.2023.153513
71
J. Mayerle, F. U. Weiss, M. M. Lerch. Pancreatitis: Advances in Pathobiology, Diagnosis and Treatment. Falk Symposium 2005; 143 doi: 10.1007/1-4020-2915-2_2
72
György Biczó, Péter Hegyi, Sándor Dósa, Natalia Shalbuyeva, Sándor Berczi, Riitta Sinervirta, Zsuzsanna Hracskó, Andrea Siska, Zoltán Kukor, Katalin Jármay, Viktória Venglovecz, Ilona S. Varga, Béla Iványi, Leena Alhonen, Tibor Wittmann, Anna Gukovskaya, Tamás Takács, Zoltán Rakonczay. The Crucial Role of Early Mitochondrial Injury in L-Lysine-Induced Acute Pancreatitis. Antioxidants & Redox Signaling 2011; 15(10) doi: 10.1089/ars.2011.4065
73
Na Hu, Yicong Shen, Fengyu Liu, Jiuping Wu, Feng Yuan, Liwei Tian, Bo Wu, Guoqing Chen, Jianming Zhang, Jun Wang. Morphological and immunobiochemical analysis of the liver in L -arginine induced experimental chronic pancreatitis. Pancreatology 2017; 17(2) doi: 10.1016/j.pan.2017.01.006
74
Lu Wang, Ting Xu, Ruifeng Wang, Xiaobing Wang, Dong Wu. Hypertriglyceridemia Acute Pancreatitis: Animal Experiment Research. Digestive Diseases and Sciences 2022; 67(3) doi: 10.1007/s10620-021-06928-0
75
Asunción Cremades, Jesús del Rio-Garcia, Ana Lambertos, Carlos López-Garcia, Rafael Peñafiel. Tissue-specific regulation of potassium homeostasis by high doses of cationic amino acids. SpringerPlus 2016; 5(1) doi: 10.1186/s40064-016-2224-3
76
Tingting Li, Fuyu Deng, Jiong Xiong, Fangqi Wu, Songxun Tang, Yijie Zhang, Qiyong Zhang, Jian Song, Yi Li, Xu Liu, Yan Tang. The mechanism of short-chain fatty acid in hypertriglyceridemic pancreatitis. Frontiers in Microbiology 2026; 16 doi: 10.3389/fmicb.2025.1714013
77
Keita Saeki, Takanori Kanai, Masaru Nakano, Yuji Nakamura, Naoteru Miyata, Tomohisa Sujino, Yoshiyuki Yamagishi, Hirotoshi Ebinuma, Hiromasa Takaishi, Yuuichi Ono, Kazuyoshi Takeda, Shigenari Hozawa, Akihiko Yoshimura, Toshifumi Hibi. CCL2-Induced Migration and SOCS3-Mediated Activation of Macrophages Are Involved in Cerulein-Induced Pancreatitis in Mice. Gastroenterology 2012; 142(4) doi: 10.1053/j.gastro.2011.12.054
78
Piyada Na Nakorn, Duangthip Chatchaisak, Boonrat Chantong, Supitcha Pannengpetch, Sasiwimon Lalitmanat, Weerapat Chawanlawuthi, Sataporn Phochantachinda. Untargeted analysis of the plasma metabolome in canine acute pancreatitis. Research in Veterinary Science 2025; 196 doi: 10.1016/j.rvsc.2025.105900
79
Aysha Samad, Andrew James, James Wong, Parini Mankad, John Whitehouse, Waseema Patel, Marta Alves-Simoes, Ajith K. Siriwardena, Jason I.E. Bruce. Insulin Protects Pancreatic Acinar Cells from Palmitoleic Acid-induced Cellular Injury. Journal of Biological Chemistry 2014; 289(34) doi: 10.1074/jbc.M114.589440
80
Caroline Mansfield. Pathophysiology of Acute Pancreatitis: Potential Application from Experimental Models and Human Medicine to Dogs. Journal of Veterinary Internal Medicine 2012; 26(4) doi: 10.1111/j.1939-1676.2012.00949.x
81
Yunlong Wang, Weiting Guo, Yuan Li, Xinting Pan, Wenshan Lv, Lingling Cui, Changgui Li, Yangang Wang, Shengli Yan, Jidong Zhang, Bin Liu. Hypothermia induced by adenosine 5′‐monophosphate attenuates injury in an L‐arginine‐induced acute pancreatitis rat model. Journal of Gastroenterology and Hepatology 2014; 29(4) doi: 10.1111/jgh.12448
82
Galande Sheethal, Archana Verma, Raghvendra Mall, Kishore VL Parsa, Ranjeet K. Tokala, Ratnakar Bynigeri, Pavan Kumar Pondugala, Krishna Vemula, S Sai Latha, Divya Tej Sowpati, Surya S. Singh, GV Rao, Rupjyoti Talukdar, Thirumala-Devi Kanneganti, D Nageshwar Reddy, Mitnala Sasikala. Modulation of Nuclear Receptor 4A1 Expression Improves Insulin Secretion in a Mouse Model of Chronic Pancreatitis. Pancreas 2024; 53(9) doi: 10.1097/MPA.0000000000002370
83
Savio G. Barreto, Colin J. Carati, Ann C. Schloithe, Ronald Mathison, Joseph S. Davison, James Toouli, Gino T.P. Saccone. The efficacy of combining feG and galantide in mild caerulein-induced acute pancreatitis in mice. Peptides 2010; 31(6) doi: 10.1016/j.peptides.2010.02.027
84
Béla Ózsvári, Péter Hegyi, Miklós Sahin-Tóth. The Guinea Pig Pancreas Secretes a Single Trypsinogen Isoform, Which Is Defective in Autoactivation. Pancreas 2008; 37(2) doi: 10.1097/MPA.0b013e3181663066
85
Zoltan Erdos, John E Barnum, Erjia Wang, Christopher DeMaula, Paritosh Markus Dey, Thomas Forest, Wendy J Bailey, Warren E Glaab. Evaluation of the Relative Performance of Pancreas-Specific MicroRNAs in Rat Plasma as Biomarkers of Pancreas Injury. Toxicological Sciences 2020; 173(1) doi: 10.1093/toxsci/kfz184
86
Po Sing Leung, Yuk Cheung Chan. Role of Oxidative Stress in Pancreatic Inflammation. Antioxidants & Redox Signaling 2009; 11(1) doi: 10.1089/ars.2008.2109
87
Shermin Chan, Karen Hon, Ruby E. Dawson, Teresa Weng, Jelena Solujic, Yu C. J. Chey, James D. Zuiani, Griffith B. Perkins, P. Toby Coates, Chris Drogemuller, Eddie Sanderlin, Lulu Huang, John Finnie, Stefan Rose‐John, Arash Badiei, Phan Nguyen, Brendan J. Jenkins, Mohamed I. Saad. The metalloproteinase ADAM17 promotes acute lung inflammatory responses during pancreatitis. British Journal of Pharmacology 2026; 183(15) doi: 10.1111/bph.70443
88
Jing Yang, Xujiao Tang, Qingqing Wu, Panpan Ren, Yishu Yan. A Severe Acute Pancreatitis Mouse Model Transited from Mild Symptoms Induced by a “Two-Hit” Strategy with L-Arginine. Life 2022; 12(1) doi: 10.3390/life12010126
89
Z Rakonczay, P Hegyi, T Takács, J McCarroll, A K Saluja. The role of NF-κB activation in the pathogenesis of acute pancreatitis. Gut 2008; 57(2) doi: 10.1136/gut.2007.124115
90
Savio G. Barreto, Colin J. Carati, Ann C. Schloithe, James Toouli, Gino T.P. Saccone. The combination of neurokinin-1 and galanin receptor antagonists ameliorates caerulein-induced acute pancreatitis in mice. Peptides 2010; 31(2) doi: 10.1016/j.peptides.2009.11.014
91
Kamatam Swetha, Mylanayakanahosahalli Chandrashekar Indumathi, Shiva Siddappa, Chu-Huang Chen, Gopal K. Marathe. Comparative Study of Non-invasive Mouse Models of Pancreatitis. Digestive Diseases and Sciences 2025; 70(1) doi: 10.1007/s10620-024-08771-5
92
Jagdeep Kaur, Shabir Sidhu, Kanwaljit Chopra, M. U. Khan. Protective effect of Mimosa pudica L. in an l-arginine model of acute necrotising pancreatitis in rats. Journal of Natural Medicines 2016; 70(3) doi: 10.1007/s11418-016-0991-3
93
Neamat H. Ahmed, Mohamed Mosleh, Faten Zahran. Relieve acute pancreatitis in Wistar rats subjected to nano-formulated metformin drug with Chitosan and/or low doses γ-Irradiation. Discover Applied Sciences 2025; 7(9) doi: 10.1007/s42452-025-07353-y
94
Guodong Yang, Xiaoying Zhang. Trimethylamine N-oxide promotes hyperlipidemia acute pancreatitis via inflammatory response. Canadian Journal of Physiology and Pharmacology 2022; 100(1) doi: 10.1139/cjpp-2021-0421
95
Sarah Klauss, Stephan Schorn, Steffen Teller, Hendrik Steenfadt, Helmut Friess, Güralp O. Ceyhan, Ihsan Ekin Demir. Genetically induced vs. classical animal models of chronic pancreatitis: a critical comparison. The FASEB Journal 2018; 32(11) doi: 10.1096/fj.201800241RR
96
Ze-peng Shen, Lin Liu, Jie Yang, Zhi-kun Zhang, Zhao-yang Du, Fu-long Zhang, Heng Zhao, Lei Li, Hai Jiang, Hong-chang Zhao, Zhao-lei Qiu. Targeting Thioredoxin Reductase 1 Alleviates Severe Acute Pancreatitis by Modulating Oxidative Stress and Ferroptosis-Related Pathways. Inflammation 2026; 49(1) doi: 10.1007/s10753-026-02454-1
97
Er-Yuan Chuang, Kun-Ju Lin, Tring-Yo Huang, Hsin-Lung Chen, Yang-Bao Miao, Po-Yen Lin, Chiung-Tong Chen, Jyuhn-Huarng Juang, Hsing-Wen Sung. An Intestinal “Transformers”-like Nanocarrier System for Enhancing the Oral Bioavailability of Poorly Water-Soluble Drugs. ACS Nano 2018; 12(7) doi: 10.1021/acsnano.8b00470
98
Eszter T. Végh, Zsolt Balla, Ágnes Dágó, Ola Salamah, Brigitta Tóth, Jason Elperin, Steven Speakman, Natalia Shalbueva, Petra Pallagi, Zsolt Rázga, Lóránd Kiss, Anna Gukovskaya, Zoltán Rakonczay. High concentrations of L-lysine cause mitochondrial damage and necrosis in isolated pancreatic acinar cells. Scientific Reports 2025; 16(1) doi: 10.1038/s41598-025-29890-7
99
Jagdeep Kaur, Shabir Sidhu, Kanwaljit Chopra, M. U. Khan. Calendula officinalisamelioratesl-arginine-induced acute necrotizing pancreatitis in rats. Pharmaceutical Biology 2016; 54(12) doi: 10.1080/13880209.2016.1195848
100
Yin Zhang, Xinlong Lin, Binhai Shen, Weifeng Huang, Qian Zhou, Gao Tan, Fachao Zhi, Erbo Liang. Caffeic acid ameliorates intestinal barrier injury to attenuate acute pancreatitis via inhibiting GSDMD-mediated pyroptotic pathway. Journal of Ethnopharmacology 2025; 353 doi: 10.1016/j.jep.2025.120261
101
T.V. Vovkun, P.I. Yanchuk, L.Y. Shtanova, A.S. Shalamaу. TISSUE BLOOD FLOW IN THE DIGESTIVE ORGANS OF RATS WITH ACUTE PANCREATITIS AFTER CORVITIN ADMINISTRATION. Fiziolohichnyĭ zhurnal 2015; 61(6) doi: 10.15407/fz61.06.053
102
Balázs Kui, Zsolt Balla, Eszter T Végh, Petra Pallagi, Viktória Venglovecz, Béla Iványi, Tamás Takács, Péter Hegyi, Zoltán Rakonczay. Recent advances in the investigation of pancreatic inflammation induced by large doses of basic amino acids in rodents. Laboratory Investigation 2014; 94(2) doi: 10.1038/labinvest.2013.143
103
Parini Mankad, Andrew James, Ajith K. Siriwardena, Austin C. Elliott, Jason I.E. Bruce. Insulin Protects Pancreatic Acinar Cells from Cytosolic Calcium Overload and Inhibition of Plasma Membrane Calcium Pump. Journal of Biological Chemistry 2012; 287(3) doi: 10.1074/jbc.M111.326272
104
Amany A. Abdin, Mohammed A. Abd El-Hamid, Samia H. Abou El-Seoud, Mohammed F.H. Balaha. Effect of pentoxifylline and/or alpha lipoic acid on experimentally induced acute pancreatitis. European Journal of Pharmacology 2010; 643(2-3) doi: 10.1016/j.ejphar.2010.06.020
105
MW Khan, S Priyamvada, SA Khan, S Khan, A Naqshbandi, ANK Yusufi. Protective effect of ω-3 polyunsaturated fatty acids on L-arginine-induced nephrotoxicity and oxidative damage in rat kidney. Human & Experimental Toxicology 2012; 31(10) doi: 10.1177/0960327112440110
106
Yan Jia, Yuxin Shi, Jie Wang, Honghui Liu, Yilin Huang, Hanyue Wang, Ya Liu, Jie Peng. Integrating metagenomics with metabolomics for gut microbiota and metabolites profiling in acute pancreatitis. Scientific Reports 2024; 14(1) doi: 10.1038/s41598-024-72057-z
107
Mohammadreza Bakhoda, Nejat Kheiripour, Keihan Ghatre-Samani, Maryam Akhavan Taheri, Fatemeh Najarzadeh, Mohammad Mehdi Haghighat Lari, Mohammad Esmaeil Shahaboddin. Ameliorating the toxicity induced by L-arginine through iris germanica methanolic extract in an experimental model of acute pancreatitis . Archives of Physiology and Biochemistry 2026; 132(1) doi: 10.1080/13813455.2025.2541699
108
Jami L. Saloman, Kathryn M. Albers, Zobeida Cruz-Monserrate, Brian M. Davis, Mouad Edderkaoui, Guido Eibl, Ariel Y. Epouhe, Jeremy Y. Gedeon, Fred S. Gorelick, Paul J. Grippo, Guy E. Groblewski, Sohail Z. Husain, Keane K.Y. Lai, Stephen J. Pandol, Aliye Uc, Li Wen, David C. Whitcomb. Animal Models. Pancreas 2019; 48(6) doi: 10.1097/MPA.0000000000001335
109
György Biczó, Péter Hegyi, Sándor Berczi, Sándor Dósa, Zsuzsanna Hracskó, Ilona S. Varga, Béla Iványi, Viktória Venglovecz, Tibor Wittmann, Tamás Takács, Zoltán Rakonczay. Inhibition of Arginase Activity Ameliorates L-Arginine-Induced Acute Pancreatitis in Rats. Pancreas 2010; 39(6) doi: 10.1097/MPA.0b013e3181d371f8
110
Constanze H. Kubisch, Maria Dolors Sans, Thiruvengadam Arumugam, Stephen A. Ernst, John A. Williams, Craig D. Logsdon. Early activation of endoplasmic reticulum stress is associated with arginine-induced acute pancreatitis. American Journal of Physiology-Gastrointestinal and Liver Physiology 2006; 291(2) doi: 10.1152/ajpgi.00471.2005
111
Zoltán Rakonczay, Péter Hegyi, Sándor Dósa, Béla Iványi, Katalin Jármay, György Biczó, Zsuzsanna Hracskó, Ilona S. Varga, Eszter Karg, József Kaszaki, András Varró, János Lonovics, Imre Boros, Ilya Gukovsky, Anna S. Gukovskaya, Stephen J. Pandol, Tamás Takács. A new severe acute necrotizing pancreatitis model induced by l-ornithine in rats. Critical Care Medicine 2008; 36(7) doi: 10.1097/CCM.0b013e31817d7f5c
112
Savio G. Barreto, Colin J. Carati, Ann C. Schloithe, James Toouli, Gino T.P. Saccone. Octreotide negates the benefit of galantide when used in the treatment of caerulein-induced acute pancreatitis in mice. HPB 2010; 12(6) doi: 10.1111/j.1477-2574.2010.00191.x
113
Murli Manohar, Alok Kumar Verma, Sathisha Upparahalli Venkateshaiah, Nathan L Sanders, Anil Mishra. Pathogenic mechanisms of pancreatitis. World Journal of Gastrointestinal Pharmacology and Therapeutics 2017; 8(1): 10-25 doi: 10.4292/wjgpt.v8.i1.10
114
Tamás Takács, Anna Szabolcs, György Biczó, Péter Hegyi, Zoltán Rakonczay. The clinical relevance of experimental acute pancreatitis models. Orvosi Hetilap 2008; 149(42) doi: 10.1556/oh.2008.28464
115
György Biczó, Péter Hegyi, Sándor Dósa, Zsolt Balla, Viktória Venglovecz, Béla Iványi, Tibor Wittmann, Tamás Takács, Zoltán Rakonczay. Aliphatic, But Not Imidazole, Basic Amino Acids Cause Severe Acute Necrotizing Pancreatitis in Rats. Pancreas 2011; 40(3) doi: 10.1097/MPA.0b013e31820a598a
116
Serkan Arslan, Mehmet Hanifi Okur, Hikmet Zeytun, Erol Basuguy, Ibrahim Ibiloglu, Ahmet Turkoglu, Zübeyr Bozdag, Ibrahim Kaplan, Unal Uluca. A new experimental rat model of pancreatitis using Ecballium elaterium. International Journal of Surgery 2015; 23 doi: 10.1016/j.ijsu.2015.09.067