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For: Frossard JL, Lescuyer P, Pastor CM. Experimental evidence of obesity as a risk factor for severe acute pancreatitis. World J Gastroenterol 2009; 15(42): 5260-5265 [PMID: 19908332 DOI: 10.3748/wjg.15.5260]
URL: https://www.wjgnet.com/1007-9327/full/v15/i42/5260.htm
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S. Dholakia, E.J. Sharples, R.J. Ploeg, P.J. Friend. Significance of steatosis in pancreatic transplantationTransplantation Reviews 2017; 31(4) doi: 10.1016/j.trre.2017.08.001
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Siavash Bolourani, Ping Wang, Matthew M. Giangola. Response regarding: Risk Factors for Early Readmission After Acute Pancreatitis: Importance of Timely InterventionsJournal of Surgical Research 2021; 258 doi: 10.1016/j.jss.2020.08.033
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Cheng-Lei Zhang, Jing-Jiao Wang, Jian-Ning Li, Yi Yang. Nonalcoholic fatty pancreas disease: An emerging clinical challengeWorld Journal of Clinical Cases 2021; 9(23): 6624-6638 doi: 10.12998/wjcc.v9.i23.6624
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Pedro Cortés, Vivek Kumbhari, Samuel O. Antwi, Michael B. Wallace, Massimo Raimondo, Baoan Ji, Yan Bi. Simple risk score to predict the likelihood of a positive EUS in idiopathic acute pancreatitisGastrointestinal Endoscopy 2022; 96(6) doi: 10.1016/j.gie.2022.07.011
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Ali Riza Koksal, Salih Boga, Huseyin Alkim, Mehmet Bayram, Meltem Ergun, Canan Alkim. Insulin Resistance as a Novel Risk Factor for Post-ERCP Pancreatitis: A Pilot StudyDigestive Diseases and Sciences 2016; 61(8) doi: 10.1007/s10620-016-4127-0
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Jean Louis Frossard, Sébastien Lenglet, Fabrizio Montecucco, Sabine Steffens, Katia Galan, Graziano Pelli, Laurent Spahr, Francois Mach, Antoine Hadengue. Role of CCL-2, CCR-2 and CCR-4 in cerulein-induced acute pancreatitis and pancreatitis-associated lung injuryJournal of Clinical Pathology 2011; 64(5) doi: 10.1136/jcp.2010.088500
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Zobeida Cruz-Monserrate, Darwin L. Conwell, Somashekar G. Krishna. The Impact of Obesity on Gallstone Disease, Acute Pancreatitis, and Pancreatic CancerGastroenterology Clinics of North America 2016; 45(4) doi: 10.1016/j.gtc.2016.07.010
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Mami Takahashi, Michihiro Mutoh, Rikako Ishigamori, Gen Fujii, Toshio Imai. Involvement of inflammatory factors in pancreatic carcinogenesis and preventive effects of anti-inflammatory agentsSeminars in Immunopathology 2013; 35(2) doi: 10.1007/s00281-012-0340-x
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Edina Bakondi, Tobias Jung, Susanna Marg, Vanessa Schnell, Daniela Weber, Tim J. Schulz, Tilman Grune, Annika Höhn. Palmitic acid and eicosapentaenoic acid supplementation in 3T3 adipocytes: impact on lipid storage and oxidative stressRedox Report 2024; 29(1) doi: 10.1080/13510002.2024.2430882
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Jason M. York, Karla J. Castellanos, Robert J. Cabay, Giamila Fantuzzi. Inhibition of the nucleotide-binding domain, leucine-rich containing family, pyrin-domain containing 3 inflammasome reduces the severity of experimentally induced acute pancreatitis in obese miceTranslational Research 2014; 164(4) doi: 10.1016/j.trsl.2014.06.012
12
Sascha Rahn, Vivien Zimmermann, Fabrice Viol, Hendrike Knaack, Kerstin Stemmer, Lena Peters, Lennart Lenk, Hendrik Ungefroren, Dieter Saur, Heiner Schäfer, Ole Helm, Susanne Sebens. Diabetes as risk factor for pancreatic cancer: Hyperglycemia promotes epithelial-mesenchymal-transition and stem cell properties in pancreatic ductal epithelial cellsCancer Letters 2018; 415 doi: 10.1016/j.canlet.2017.12.004
13
Jana Katuchova, Juraj Bober, Pavol Harbulak, Alexander Hudak, Tomas Gajdzik, Rastislav Kalanin, Jozef Radonak. Obesity as a risk factor for severe acute pancreatitis patientsWiener klinische Wochenschrift 2014; 126(7-8) doi: 10.1007/s00508-014-0507-7
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I. Mikolasevic, S. Milic, L. Orlic, G. Poropat, I. Jakopcic, N. Franjic, A. Klanac, N. Kristo, D. Stimac. Metabolic syndrome and acute pancreatitisEuropean Journal of Internal Medicine 2016; 32 doi: 10.1016/j.ejim.2016.04.004
15
Leonilde Bonfrate, David Q-H. Wang, Gabriella Garruti, Piero Portincasa. Obesity and the risk and prognosis of gallstone disease and pancreatitisBest Practice & Research Clinical Gastroenterology 2014; 28(4) doi: 10.1016/j.bpg.2014.07.013
16
Shaikh Hai, Evander Meneses, Mark McKenney, Adel Elkbuli. Letter regarding: Risk Factors for Early Readmission After Acute Pancreatitis: Importance of Timely InterventionsJournal of Surgical Research 2021; 258 doi: 10.1016/j.jss.2020.07.082
17
Pedro H. Marchi, Thiago H. A. Vendramini, Mariana P. Perini, Rafael V. A. Zafalon, Andressa R. Amaral, Vanessa A. Ochamotto, Juliano C. Da Silveira, Maria L. Z. Dagli, Marcio A. Brunetto. Obesity, inflammation, and cancer in dogs: Review and perspectivesFrontiers in Veterinary Science 2022; 9 doi: 10.3389/fvets.2022.1004122
18
晶 夏. Research Progress of Diabetes Mellitus after Acute PancreatitisAdvances in Clinical Medicine 2023; 13(07) doi: 10.12677/ACM.2023.1371515
19
Hamid Reza Akbarzadeh Zarei, Mandana Gholami, Farshad Ghazalian, Sahar Ghareh. Aerobic training and cannabidiol activate the PI3K/AKT/PDX1 axis to ameliorate beta-cell dysfunction in a rat model of diet-induced obesityMolecular Biology Reports 2026; 53(1) doi: 10.1007/s11033-026-11573-9
20
Congye Wu, Lu Ke, Zhihui Tong, Baiqiang Li, Lei Zou, Weiqin Li, Ning Li, Jieshou Li. Hypertriglyceridemia is a Risk Factor for Acute Kidney Injury in the Early Phase of Acute PancreatitisPancreas 2014; 43(8) doi: 10.1097/MPA.0000000000000180
21
Yariv Kanfi, Victoria Peshti, Reuven Gil, Shoshana Naiman, Liat Nahum, Eran Levin, Noga Kronfeld‐Schor, Haim Y. Cohen. SIRT6 protects against pathological damage caused by diet‐induced obesityAging Cell 2010; 9(2) doi: 10.1111/j.1474-9726.2009.00544.x
22
Yongyan Song, Huan Deng, Jie Zhou, Ji Sun, Xiaoming Zhang, Yixing Ren. The Effects of Laparoscopic Sleeve Gastrectomy on Obesity-Related Hypertriglyceridemia-Induced Acute PancreatitisObesity Surgery 2018; 28(12) doi: 10.1007/s11695-018-3446-y
23
Indu Pathak, Diana Malbas, Pukhraj Rai, Alok Kumar Dwivedi. Association of Obesity in Children with Pancreatitis in a Predominantly Hispanic Population at the US-Mexican Border: A Single Center Outpatient StudyHealth 2016; 8(15) doi: 10.4236/health.2016.815174
24
Abigail Maisey. A Practical Approach to Gastrointestinal Complications of DiabetesDiabetes Therapy 2016; 7(3) doi: 10.1007/s13300-016-0182-y
25
Bryan C Bergman, Karin Zemski Berry, Amanda Garfield, Amy Keller, Simona Zarini, Sophia Bowen, Colleen McKenna, Darcy Kahn, Jay Pavelka, Emily Macias, Charis Uhlson, Chris Johnson, Holger A Russ, Carlos H Viesi, Marcus Seldin, Chengyang Liu, Nicolai M Doliba, Jonathan Schoen, Kevin Rothchild, Kweku Hazel, Ali Naji. Human Peripancreatic Adipose Tissue Paracrine Signaling Impacts Insulin Secretion, Blood Flow, and Gene TranscriptionThe Journal of Clinical Endocrinology & Metabolism 2025; 110(7) doi: 10.1210/clinem/dgae767
26
Ilya Gukovsky, Ning Li, Jelena Todoric, Anna Gukovskaya, Michael Karin. Inflammation, Autophagy, and Obesity: Common Features in the Pathogenesis of Pancreatitis and Pancreatic CancerGastroenterology 2013; 144(6) doi: 10.1053/j.gastro.2013.02.007
27
Yilin Wang, Weiyan Liu, Xiqiang Liu, Meng Sheng, Yaofei Pei, Ruoqing Lei, Shengdao Zhang, Ran Tao. Role of Liver in Modulating the Release of Inflammatory Cytokines Involved in Lung and Multiple Organ Dysfunction in Severe Acute PancreatitisCell Biochemistry and Biophysics 2015; 71(2) doi: 10.1007/s12013-014-0261-5
28
Mark M. Smits, Erwin J. M. van Geenen. The clinical significance of pancreatic steatosisNature Reviews Gastroenterology & Hepatology 2011; 8(3) doi: 10.1038/nrgastro.2011.4
29
Xu Li, Xiaolin Guo, Huifan Ji, Junqi Niu, Pujun Gao. Relationships between Metabolic Comorbidities and Occurrence, Severity, and Outcomes in Patients with Acute Pancreatitis: A Narrative ReviewBioMed Research International 2019; 2019 doi: 10.1155/2019/2645926
30
Ho Gak Kim, Jimin Han. Obesity and Pancreatic DiseasesThe Korean Journal of Gastroenterology 2012; 59(1) doi: 10.4166/kjg.2012.59.1.35
31
T.C. Hall, J.S. Stephenson, M.J. Jones, W.S. Ngu, M.A. Horsfield, A. Rajesh, A.R. Dennison, G. Garcea. Is Abdominal Fat Distribution Measured by Axial CT Imaging an Indicator of Complications and Mortality in Acute Pancreatitis?Journal of Gastrointestinal Surgery 2015; 19(12) doi: 10.1007/s11605-015-2972-3
32
Nicholas S. Solanki, Savio G. Barreto, Gino T.P. Saccone. Acute pancreatitis due to diabetes: The role of hyperglycaemia and insulin resistancePancreatology 2012; 12(3) doi: 10.1016/j.pan.2012.01.003
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Cheng Ye, Rui Wang, Mojin Wang, Zhiyin Huang, Chengwei Tang. Leptin alleviates intestinal mucosal barrier injury and inflammation in obese mice with acute pancreatitisInternational Journal of Obesity 2018; 42(8) doi: 10.1038/s41366-018-0125-y
34
Risheng Ye, Olga A. Mareninova, Ernesto Barron, Miao Wang, David R. Hinton, Stephen J. Pandol, Amy S. Lee. Grp78 Heterozygosity Regulates Chaperone Balance in Exocrine Pancreas with Differential Response to Cerulein-Induced Acute PancreatitisThe American Journal of Pathology 2010; 177(6) doi: 10.2353/ajpath.2010.100368
35
Peter Manu, Matisyahu Shulman, Kathlyn J. Ronaldson. Life-Threatening Effects of Antipsychotic Drugs2016;  doi: 10.1016/B978-0-12-803376-0.00008-3
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Antonio López-Serrano, Inmaculada Ortiz Polo, Javier Sanz de la Vega, Eduardo Moreno-Osset. Role of the gastroenterologist in the management of the obese patientGastroenterología y Hepatología (English Edition) 2017; 40(6) doi: 10.1016/j.gastre.2017.05.005
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Toshio Fujisawa, Koichi Kagawa, Kantaro Hisatomi, Kensuke Kubota, Hajime Sato, Atsushi Nakajima, Nobuyuki Matsuhashi. Obesity with abundant subcutaneous adipose tissue increases the risk of post-ERCP pancreatitisJournal of Gastroenterology 2016; 51(9) doi: 10.1007/s00535-016-1160-x
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Qiao Yu, Tao Xu, Feifei Ding, Zhen Ding, Rong Lin. Decreased infiltration of adipose tissue macrophages and amplified inflammation of adipose tissue in obese mice with severe acute pancreatitisPancreatology 2021; 21(6) doi: 10.1016/j.pan.2021.05.005
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Yuan Tian, Qing Huang, Yu-Tang Ren, Xuan Jiang, Bo Jiang. Visceral adipose tissue predicts severity and prognosis of acute pancreatitis in obese patientsHepatobiliary & Pancreatic Diseases International 2024; 23(5) doi: 10.1016/j.hbpd.2023.08.014
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Dilinigeer Tayier, Kunlei Wang, Yufeng Yuan, Zhiyong Yang. Research Status on the Effects of Obesity on Acute PancreatitisObesity Reviews 2026; 27(1) doi: 10.1111/obr.70007
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Ahmed A. M. Moustafa, Ibrahim A. Abdelazim. Impact of obesity on recovery and pulmonary functions of obese women undergoing major abdominal gynecological surgeriesJournal of Clinical Monitoring and Computing 2016; 30(3) doi: 10.1007/s10877-015-9722-7
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Kumaresan Sandrasegaran, Chen Lin, Fatih M. Akisik, Mark Tann. State-of-the-Art Pancreatic MRIAmerican Journal of Roentgenology 2010; 195(1) doi: 10.2214/AJR.10.4421
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Roberto Catanzaro, Biagio Cuffari, Angelo Italia, Francesco Marotta. Exploring the metabolic syndrome: Nonalcoholic fatty pancreas diseaseWorld Journal of Gastroenterology 2016; 22(34): 7660-7675 doi: 10.3748/wjg.v22.i34.7660
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Su Mei CHEN, Guang Su XIONG, Shu Ming WU. Is obesity an indicator of complications and mortality in acute pancreatitis? An updated meta‐analysisJournal of Digestive Diseases 2012; 13(5) doi: 10.1111/j.1751-2980.2012.00587.x
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A. Murata, M. Ohtani, K. Muramatsu, S. Kobori, S. Tomioka, S. Matsuda. Impact of obesity on outcomes of paediatric acute pancreatitis based on a national administrative databasePediatric Obesity 2016; 11(3) doi: 10.1111/ijpo.12041
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Elmukhtar Habas, Kalifa Farfar, Eshrak Habas, Amnna Rayani, Abdul-Naser Elzouki. Extended Review and Updates of Nonalcoholic Fatty Pancreas DiseaseSaudi Journal of Medicine & Medical Sciences 2024; 12(4) doi: 10.4103/sjmms.sjmms_526_23
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Laura Cortese, Giuseppe Terrazzano, Alessandra Pelagalli. Leptin and Immunological Profile in Obesity and Its Associated Diseases in DogsInternational Journal of Molecular Sciences 2019; 20(10) doi: 10.3390/ijms20102392
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Valeria Guglielmi, Paolo Sbraccia. Type 2 diabetes: Does pancreatic fat really matter?Diabetes/Metabolism Research and Reviews 2018; 34(2) doi: 10.1002/dmrr.2955
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Ryan Kolb, Fayyaz S Sutterwala, Weizhou Zhang. Obesity and cancer: inflammation bridges the twoCurrent Opinion in Pharmacology 2016; 29 doi: 10.1016/j.coph.2016.07.005
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Current World LiteratureCurrent Opinion in Endocrinology, Diabetes & Obesity 2011; 18(1) doi: 10.1097/MED.0b013e3283432fa7
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Philip J. B. Davis, Karim M. Eltawil, Bassam Abu‐Wasel, Mark J. Walsh, Trevor Topp, Michele Molinari. Effect of Obesity and Decompressive Laparotomy on Mortality in Acute Pancreatitis Requiring Intensive Care Unit AdmissionWorld Journal of Surgery 2013; 37(2) doi: 10.1007/s00268-012-1821-8
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Praveen S. Goday, Martin Wakeham, Evelyn M. Kuhn, Maureen M. Collins, Steven L. Werlin. Acute Pancreatitis in the Pediatric Intensive Care UnitJournal of Pediatric Gastroenterology and Nutrition 2015; 61(1) doi: 10.1097/MPG.0000000000000780
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Somashekar G Krishna, Alice Hinton, Veeral Oza, Phil A Hart, Eric Swei, Samer El-Dika, Peter P Stanich, Hisham Hussan, Cheng Zhang, Darwin L Conwell. Morbid Obesity Is Associated With Adverse Clinical Outcomes in Acute Pancreatitis: A Propensity-Matched StudyAmerican Journal of Gastroenterology 2015; 110(11) doi: 10.1038/ajg.2015.343
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Byung Ok Kwak, Min Jung Lee, Hye Won Park, Kyo Sun Kim, Sochung Chung. A case of recurrent acute pancreatitis in an obese childNutrition 2014; 30(10) doi: 10.1016/j.nut.2014.04.002
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Fabíula Francisca Abreu, Ana Carla Araújo Souza, Simone Aparecida Teixeira, Antônio Garcia Soares, Daiane Franco Teixeira, Rosilene Calazans Soares, Marilia Trindade Santana, Sandra Lauton Santos, Soraia Kátia Pereira Costa, Marcelo Nicolas Muscará, Enilton Aparecido Camargo. Elucidating the role of oxidative stress in the therapeutic effect of rutin on experimental acute pancreatitisFree Radical Research 2016; 50(12) doi: 10.1080/10715762.2016.1247494
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Jolanta Jaworek, Stanisław Jan Konturek. Hormonal protection in acute pancreatitis by ghrelin, leptin and melatoninWorld Journal of Gastroenterology 2014; 20(45): 16902-16912 doi: 10.3748/wjg.v20.i45.16902
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Ilaria Casari, Marco Falasca. Diet and Pancreatic Cancer PreventionCancers 2015; 7(4) doi: 10.3390/cancers7040892
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Wei Liu, Zenghui Li, Xinyu Zhang, Juanjuan Du, Rui Liang, Yifan Ji, Wei Tang, Xiaoming Zhang. CT Characteristics of Acute Pancreatitis with Preexisting Fatty Liver and Its Impact on Pancreatitis Severity and Persistent Systemic Inflammatory Response SyndromeInternational Journal of General Medicine 2022;  doi: 10.2147/IJGM.S382287
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N. S. Gavrilina, L. Yu. Ilchenko, I. G. Fedorov, I. G. Nikitin. COMBINATION OF O BESITY AND MALNUTRITION AT A PATIENT WITH CHRONIC ALCOHOLIC PANCREATITIS (CASE REPORT)The Russian Archives of Internal Medicine 2018; 8(6) doi: 10.20514/2226-6704-2018-8-6-475-479
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Reda H. Elbakary, Naglaa A. Bayomy. Histological and immunohistochemical study of the effect of orlistat on the exocrine pancreas of adult female albino ratThe Egyptian Journal of Histology 2011; 34(2) doi: 10.1097/01.EHX.0000396877.23400.14
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Freja K. Jørgensen, Charlotte R. Bjornvad, Birgit Krabbe, Stinna Nybroe, Ida N. Kieler. Evaluation of laboratory findings indicating pancreatitis in healthy lean, obese, and diabetic catsJournal of Veterinary Internal Medicine 2025; 39(1) doi: 10.1111/jvim.17236
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Ahmet Ziya Balta, Yavuz Ozdemir, Ilker Sucullu, Mehmet Levhi Akin, Sezai Demirbas. Early Detection of Potentially Severe Acute PancreatitisJournal of the American College of Surgeons 2014; 218(5) doi: 10.1016/j.jamcollsurg.2014.02.009
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Michael H. Ma, Harrison X. Bai, Alexander J. Park, Sahibzada U. Latif, Pramod K. Mistry, Dinesh Pashankar, Veronika S. Northrup, Vineet Bhandari, Sohail Z. Husain. Risk Factors Associated With Biliary Pancreatitis in ChildrenJournal of Pediatric Gastroenterology and Nutrition 2012; 54(5) doi: 10.1097/MPG.0b013e31823a897d
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Cheng Ye, Ling Liu, Xiao Ma, Huan Tong, Jinhang Gao, Yang Tai, Libin Huang, Chengwei Tang, Rui Wang. Obesity Aggravates Acute Pancreatitis via Damaging Intestinal Mucosal Barrier and Changing Microbiota Composition in RatsScientific Reports 2019; 9(1) doi: 10.1038/s41598-018-36266-7
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Hoongoo Lee, Dong Hee Koh. Obesity and Pancreatobiliary DiseaseThe Korean Journal of Gastroenterology 2020; 75(5) doi: 10.4166/kjg.2020.75.5.240
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Zhenghang Yu, Dianyuan Liang, Zhongyang Zhang, Ke Song, Yuan Zhang, Yin Xian, Ming He, Xing Xie, Sijun Xie, Xiangxin Kong, Yixing Ren. Efficacy of Metabolic and Bariatric Surgery for the Treatment of Recurrent Hypertriglyceridemia-Induced Acute PancreatitisObesity Surgery 2025; 35(4) doi: 10.1007/s11695-025-07742-7
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Antonio López-Serrano, Inmaculada Ortiz Polo, Javier Sanz de la Vega, Eduardo Moreno-Osset. Papel del digestólogo en el manejo del paciente obesoGastroenterología y Hepatología 2017; 40(6) doi: 10.1016/j.gastrohep.2016.08.001
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Ji Young Park, Tae Joo Jeon, Tae Hwan Ha, Jin Tae Hwang, Dong Hyun Sinn, Tae-Hoon Oh, Won Chang Shin, Won-Choong Choi. Bedside index for severity in acute pancreatitis: comparison with other scoring systems in predicting severity and organ failureHepatobiliary & Pancreatic Diseases International 2013; 12(6) doi: 10.1016/S1499-3872(13)60101-0