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For: Grattagliano I, Bonfrate L, Diogo CV, Wang HH, Wang DQ, Portincasa P. Biochemical mechanisms in drug-induced liver injury: Certainties and doubts. World J Gastroenterol 2009; 15(39): 4865-4876 [PMID: 19842215 DOI: 10.3748/wjg.15.4865]
URL: https://www.wjgnet.com/1007-9327/full/v15/i39/4865.htm
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Emilio Molina-Molina, Harshitha Shanmugam, Domenica Di Palo, Ignazio Grattagliano, Piero Portincasa. Mitochondrial Regulation. Methods in Molecular Biology 2021; 2310 doi: 10.1007/978-1-0716-1433-4_11
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Diagnostic Imaging: Gastrointestinal. 2015;  doi: 10.1016/B978-0-323-37755-3.50200-2
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Nadezda Apostolova. Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. 2014;  doi: 10.1016/B978-0-12-405529-2.00005-6
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Alejandra Cano Paniagua, Pedro Amariles. Pharmacokinetics and Adverse Effects of Drugs - Mechanisms and Risks Factors. 2018;  doi: 10.5772/intechopen.72005
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Ignazio Grattagliano, Leonilde Bonfrate, Michele Lorusso, Luigi Castorani, Ornella de Bari, Piero Portincasa. Mitochondrial Regulation. Methods in Molecular Biology 2015; 1241 doi: 10.1007/978-1-4939-1875-1_12
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Yun Wei, Meixia Liu, Jiangang Liu, Hao Li. Influence Factors on the Hepatotoxicity ofPolygoni Multiflori Radix. Evidence-Based Complementary and Alternative Medicine 2019; 2019 doi: 10.1155/2019/5482896
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María Teresa Donato, Laia Tolosa. High-Content Screening for the Detection of Drug-Induced Oxidative Stress in Liver Cells. Antioxidants 2021; 10(1) doi: 10.3390/antiox10010106
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Angelica Kresnamurti, Dita Nurlita Rakhma, Amitasari Damayanti, Septiyan Dwi Santoso, Enggar Restryarto, Wifqi Hadinata, Iwan Sahrial Hamid. AST/ALT levels, MDA, and liver histopathology of Echinometra mathaei ethanol extract on paracetamol-induced hepatotoxicity in rats. Journal of Basic and Clinical Physiology and Pharmacology 2021; 32(4) doi: 10.1515/jbcpp-2020-0420
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Mehboob Ali, Sagheer Ahmed Khan, Peter S. Chang, Rizwanul Haque, Kanchan Bhatia, Saif Ahmad. Habb-e-Asgand, polyherbal Unani formulation, protects liver and antioxidative enzymes against paracetamol induced hepatotoxicity. Pharmaceutical Biology 2014; 52(4) doi: 10.3109/13880209.2013.863949
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Tomáš Smutný, Riina Harjumäki, Liisa Kanninen, Marjo Yliperttula, Petr Pávek, Yan-Ru Lou. A feasibility study of the toxic responses of human induced pluripotent stem cell-derived hepatocytes to phytochemicals. Toxicology in Vitro 2018; 52 doi: 10.1016/j.tiv.2018.06.012
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Arthur Shiyovich, Lior Nesher, Ignacio Sztarkier. Toxic Hepatitis Induced by Gymnema sylvestre, a Natural Remedy for Type 2 Diabetes Mellitus. The American Journal of the Medical Sciences 2010; 340(6) doi: 10.1097/MAJ.0b013e3181f41168
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Mohamed Elsayed Kelany, Mohamed Abdelmohsen Abdallah. Protective effects of combined β-caryophyllene and silymarin against ketoprofen-induced hepatotoxicity in rats. Canadian Journal of Physiology and Pharmacology 2016; 94(7) doi: 10.1139/cjpp-2015-0607
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Ruo-Lan Li, Feng Gao, Shu-Ting Yan, Li Ou, Ming Li, Lin Chen, Pei-Feng Wei, Zong-Qiang Gao, Rômulo Dias Novaes. Effects of Different Processed Products of Polygonum multiflorum on the Liver. Evidence-Based Complementary and Alternative Medicine 2020; 2020(1) doi: 10.1155/2020/5235271
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Patrick J. Shaw, Patricia E. Ganey, Robert A. Roth. Idiosyncratic Drug-Induced Liver Injury and the Role of Inflammatory Stress with an Emphasis on an Animal Model of Trovafloxacin Hepatotoxicity. Toxicological Sciences 2010; 118(1) doi: 10.1093/toxsci/kfq168
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The Maudsley Prescribing Guidelines in Psychiatry. 2025;  doi: 10.1002/9781119870203.mpg008.pub2
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Salman R. Khetani, Chitra Kanchagar, Okechukwu Ukairo, Stacy Krzyzewski, Amanda Moore, Julianne Shi, Simon Aoyama, Michael Aleo, Yvonne Will. Use of Micropatterned Cocultures to Detect Compounds That Cause Drug-Induced Liver Injury in Humans. Toxicological Sciences 2013; 132(1) doi: 10.1093/toxsci/kfs326
18
Z. Zazuli, M. I. Barliana, U. A. Mulyani, D. A. Perwitasari, H. Ng, R. Abdulah. Polymorphism ofPXRgene associated with the increased risk of drug-induced liver injury in Indonesian pulmonary tuberculosis patients. Journal of Clinical Pharmacy and Therapeutics 2015; 40(6) doi: 10.1111/jcpt.12325
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Akram Eidi, Pejman Mortazavi, Jalal Zarringhalam Moghadam, Parisa Mousavi Mardani. Hepatoprotective effects of Portulaca oleracea extract against CCl 4 -induced damage in rats . Pharmaceutical Biology 2015; 53(7) doi: 10.3109/13880209.2014.957783
20
Jeffrey C. Wolf, James R. Wheeler. A critical review of histopathological findings associated with endocrine and non-endocrine hepatic toxicity in fish models. Aquatic Toxicology 2018; 197 doi: 10.1016/j.aquatox.2018.01.013
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John Oludele Olanlokun, Olusola Bodede, Gerhard Prinsloo, Olufunso Olabode Olorunsogo. Comparative antimalarial, toxicity and mito-protective effects of Diospyros mespiliformis Hochst. ex A. DC. and Mondia whitei (Hook.f.) Skeels on Plasmodium berghei infection in mice. Journal of Ethnopharmacology 2021; 268 doi: 10.1016/j.jep.2020.113585
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Maria Grazia Anelli, Crescenzio Scioscia, Ignazio Grattagliano, Giovanni Lapadula. Old and New Antirheumatic Drugs and the Risk of Hepatotoxicity. Therapeutic Drug Monitoring 2012; 34(6) doi: 10.1097/FTD.0b013e31826a6306
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Chase P. Monckton, Grace E. Brown, Salman R. Khetani. Latest impact of engineered human liver platforms on drug development. APL Bioengineering 2021; 5(3) doi: 10.1063/5.0051765
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Shimaa O. Ali, Hebatallah A. Darwish, Nabila A. Ismail. Curcumin, Silybin Phytosome® and α‐R‐Lipoic Acid Mitigate Chronic Hepatitis in Rat by Inhibiting Oxidative Stress and Inflammatory Cytokines Production. Basic & Clinical Pharmacology & Toxicology 2016; 118(5) doi: 10.1111/bcpt.12502
25
Mohamed Hamed, Nasser S. Abou Khalil, Alshaimaa A.I. Alghriany, Alaa El-Din H. Sayed. The protective effects of dietary microalgae against hematological, biochemical, and histopathological alterations in pyrogallol-intoxicated Clarias gariepinus. Heliyon 2024; 10(24) doi: 10.1016/j.heliyon.2024.e40930
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M.G.L. Elferink, P. Olinga, E.M. van Leeuwen, S. Bauerschmidt, J. Polman, W.G. Schoonen, S.H. Heisterkamp, G.M.M. Groothuis. Gene expression analysis of precision-cut human liver slices indicates stable expression of ADME-Tox related genes. Toxicology and Applied Pharmacology 2011; 253(1) doi: 10.1016/j.taap.2011.03.010
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Dalia Amer Khudhair. Pathological Changes of Rifampicin Toxicity on Some Organs in Rats. Medical Journal of Babylon 2025; 22(2) doi: 10.4103/MJBL.MJBL_515_24
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J M Harrold, M Ramanathan, D E Mager. Network-Based Approaches in Drug Discovery and Early Development. Clinical Pharmacology & Therapeutics 2013; 94(6) doi: 10.1038/clpt.2013.176
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Herson González-Ponce, Ana Rincón-Sánchez, Fernando Jaramillo-Juárez, Han Moshage. Natural Dietary Pigments: Potential Mediators against Hepatic Damage Induced by Over-The-Counter Non-Steroidal Anti-Inflammatory and Analgesic Drugs. Nutrients 2018; 10(2) doi: 10.3390/nu10020117
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Magd A. Kotb. Molecular Mechanisms of Ursodeoxycholic Acid Toxicity & Side Effects: Ursodeoxycholic Acid Freezes Regeneration & Induces Hibernation Mode. International Journal of Molecular Sciences 2012; 13(7) doi: 10.3390/ijms13078882
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Lin Niu, Yunlan Li, Qingshan Li. Medicinal properties of organotin compounds and their limitations caused by toxicity. Inorganica Chimica Acta 2014; 423 doi: 10.1016/j.ica.2014.05.007
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Timothy E. H. Allen, Jonathan M. Goodman, Steve Gutsell, Paul J. Russell. Defining Molecular Initiating Events in the Adverse Outcome Pathway Framework for Risk Assessment. Chemical Research in Toxicology 2014; 27(12) doi: 10.1021/tx500345j
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Ahmad Sharanek, Audrey Burban, Lydie Humbert, Pamela Bachour-El Azzi, Neuza Felix-Gomes, Dominique Rainteau, Andre Guillouzo. Cellular Accumulation and Toxic Effects of Bile Acids in Cyclosporine A-Treated HepaRG Hepatocytes. Toxicological Sciences 2015; 147(2) doi: 10.1093/toxsci/kfv155
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Anna F. Castoldi, Tamara Coja, Anna Lanzoni, Kyriaki Machera, Luc Mohimont, Monica Nepal, Camilla Recordati, Federica Crivellente. Specific effects on liver relevant for performing a dietary cumulative risk assessment of pesticide residues. EFSA Journal 2025; 23(5) doi: 10.2903/j.efsa.2025.9409
36
Makiko Adachi, Takeshi Kumagai, Keiko Hosho, Kiyoshi Nagata, Masachika Fujiyoshi, Miki Shimada. Exploring Acute Liver Damage: Slimming Health Foods and CYP3A4 Induction. Yonago Acta Medica 2024; 67(2) doi: 10.33160/yam.2024.05.004
37
Lyvia Lintzmaier Petiz, Amanda do Rocio Andrade Pires, Aurea Echevarria, Cláudio Eduardo Rodrigues-Santos, Maria Eliane Merlin Rocha, Alexandra Acco, Silvia Maria Suter Correia Cadena. Effects of a new antiprotozoal drug, N,N′-diphenyl-4-methoxy-benzamidine, on energy-linked functions of rat liver mitochondria. Chemico-Biological Interactions 2018; 279 doi: 10.1016/j.cbi.2017.11.006
38
Shukrullo Zuloliddinovich Otaev, Bobodzhon Komiljonovich Valiev, Shokhin Kuvvatovich Nazarov, Alisher Rakhmatulloevich Saraev, Loik Abdurakhmonovich Gulomov, Ainur Ergalievna Donaeva, Ainur Izatullaevna Zakirova, Zhadyra Aldebaevna Sisenova. The influence of microflora on the barrier function of the liver in widespread purulent peritonitis. Eurasian scientific and medical journal «Sino» 2025; 6(2) doi: 10.54538/2707-5265-2025-6-2-35-46
39
Shahparan Islam Shawon, Rashmia Nargis Reyda, Nazmul Qais. Medicinal herbs and their metabolites with biological potential to protect and combat liver toxicity and its disorders: A review. Heliyon 2024; 10(3) doi: 10.1016/j.heliyon.2024.e25340
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Ochuko L. Erukainure, Olakunle Sanni, Veronica F. Salau, Neil A. Koorbanally, Md. Shahidul Islam. Cola Nitida (Kola Nuts) Attenuates Hepatic Injury in Type 2 Diabetes by Improving Antioxidant and Cholinergic Dysfunctions and Dysregulated Lipid Metabolism. Endocrine, Metabolic & Immune Disorders - Drug Targets 2021; 21(4) doi: 10.2174/1871530320666200628030138
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Pinar Erkekoglu. Cellular and Molecular Aspects of Drug-Induced Liver Toxicity: Recent Prominent Mechanisms. MOJ Toxicology 2015; 1(5) doi: 10.15406/mojt.2015.01.00023
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Afolabi C. Akinmoladun, Comfort Odunayo Oladejo, Sunday Solomon Josiah, Courage Dele Famusiwa, Olubukola Benedicta Ojo, M. Tolulope Olaleye. Catechin, quercetin and taxifolin improve redox and biochemical imbalances in rotenone-induced hepatocellular dysfunction: Relevance for therapy in pesticide-induced liver toxicity?. Pathophysiology 2018; 25(4) doi: 10.1016/j.pathophys.2018.07.002
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David Q.‐H. Wang, Piero Portincasa, Brent A. Neuschwander‐Tetri. Comprehensive Physiology. 2013;  doi: 10.1002/cphy.c130001
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Tahir Maqbool Mir, Muneeb U Rehman, Mohammad Khalid Ashfaq, Wajhul Qamar, Rehan Khan, Aarif Ali, Mansour Almuqbil, Sultan Alshehri, Sarwat Sultana. Carum carvi Modulates Acetaminophen-Induced Hepatotoxicity: Effects on TNF-α, NF-κB, and Caspases. Applied Sciences 2022; 12(21) doi: 10.3390/app122111010
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Emmanuel Simon, P. Aswini, V. B. Sameer Kumar, Gokuldas Mankadath. Curcumin and its synthetic analogue dimethoxycurcumin differentially modulates antioxidant status of normal human peripheral blood mononuclear cells. Free Radical Research 2018; 52(5) doi: 10.1080/10715762.2018.1455002
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The Maudsley Prescribing Guidelines in Psychiatry. 2021;  doi: 10.1002/9781119870203.mpg008
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Tasleem Akhtar, Nadeem Sheikh. An overview of thioacetamide-induced hepatotoxicity. Toxin Reviews 2013; 32(3) doi: 10.3109/15569543.2013.805144
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Henrik Cordes, Christoph Thiel, Vanessa Baier, Lars M. Blank, Lars Kuepfer. Integration of genome-scale metabolic networks into whole-body PBPK models shows phenotype-specific cases of drug-induced metabolic perturbation. npj Systems Biology and Applications 2018; 4(1) doi: 10.1038/s41540-018-0048-1
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N. P. Sudheesh, T. A. Ajith, K. K. Janardhanan. Hepatoprotective effects of DL-α-lipoic acid and α-Tocopherol through amelioration of the mitochondrial oxidative stress in acetaminophen challenged rats. Toxicology Mechanisms and Methods 2013; 23(5) doi: 10.3109/15376516.2013.769289
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Arvind Pradip, Daniella Steel, Susanna Jacobsson, Gustav Holmgren, Magnus Ingelman-Sundberg, Peter Sartipy, Petter Björquist, Inger Johansson, Josefina Edsbagge, Toon van Veen. High Content Analysis of Human Pluripotent Stem Cell Derived Hepatocytes Reveals Drug Induced Steatosis and Phospholipidosis. Stem Cells International 2016; 2016(1) doi: 10.1155/2016/2475631
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Laia Tolosa, Idania Rodeiro, M Teresa Donato, José A Herrera, René Delgado, José V Castell, M José Gómez-Lechón. Multiparametric evaluation of the cytoprotective effect of the Mangifera indica L. stem bark extract and mangiferin in HepG2 cells. Journal of Pharmacy and Pharmacology 2013; 65(7) doi: 10.1111/jphp.12071
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Ana S. Serras, Joana S. Rodrigues, Madalena Cipriano, Armanda V. Rodrigues, Nuno G. Oliveira, Joana P. Miranda. A Critical Perspective on 3D Liver Models for Drug Metabolism and Toxicology Studies. Frontiers in Cell and Developmental Biology 2021; 9 doi: 10.3389/fcell.2021.626805
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Weibin Li, Weijian Chen, Shengyue Lin, Guojun Cai, Ziyan Deng, Yongqing Zhang, Haiying Yang, Qiang Li, Chong Han. Organ-Specific Toxicity of Lynestrenol in Mandarin Fish: Hepatic Metabolic Collapse versus Ovarian Resilience through Efflux Transporter Activation. Environmental Science & Technology 2026; 60(37) doi: 10.1021/acs.est.6c07917
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Hanène Ben Miled, Zaineb Ben Barka, Dorsaf Hallègue, Karima Lahbib, Mohamed Ladjimi, Mounira Tlili, Mohsen Sakly, Khémais Ben Rhouma, Riadh Ksouri, Olfa Tebourbi. Hepatoprotective activity of Rhus oxyacantha root cortex extract against DDT-induced liver injury in rats. Biomedicine & Pharmacotherapy 2017; 90 doi: 10.1016/j.biopha.2017.03.063
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Amy J Stefanowicz, Leslie Recio, Michael B Black, Tyler Beames, Melvin E Andersen, R Allysa Stern, Rebecca A Clewell, Patrick D McMullen, Jessica K Hartman, Aarati Ranade. Comparison of Rat Hepatocyte 2D-Monocultures and Hepatocytes Non-Parenchymal Cell Co-Cultures for Assessing Chemical Toxicity. International Journal of Toxicology 2023; 42(1) doi: 10.1177/10915818221139471
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Linrong Chen, Xu Zhen, Xiqun Jiang. Activatable Optical Probes for Fluorescence and Photoacoustic Imaging of Drug‐Induced Liver Injury. Advanced NanoBiomed Research 2022; 2(12) doi: 10.1002/anbr.202200097
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Andrés Tabernilla, Bruna dos Santos Rodrigues, Alanah Pieters, Anne Caufriez, Kaat Leroy, Raf Van Campenhout, Axelle Cooreman, Ana Rita Gomes, Emma Arnesdotter, Eva Gijbels, Mathieu Vinken. In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach. International Journal of Molecular Sciences 2021; 22(9) doi: 10.3390/ijms22095038
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Sherifa S. Hamed, Nouf A. AL-Yhya, Manal F. El-Khadragy, Ebtesam M. Al-Olayan, Reem A. Alajmi, Zeinab K. Hassan, Salwa B. Hassan, Ahmed E. Abdel Moneim. The Protective Properties of the Strawberry (Fragaria ananassa) against Carbon Tetrachloride-Induced Hepatotoxicity in Rats Mediated by Anti-Apoptotic and Upregulation of Antioxidant Genes Expression Effects. Frontiers in Physiology 2016; 7 doi: 10.3389/fphys.2016.00325
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Ji-Hee Hwang, Minyoung Lim, Gyeongjin Han, Heejin Park, Yong-Bum Kim, Jinseok Park, Sang-Yeop Jun, Jaeku Lee, Jae-Woo Cho. A comparative study on the implementation of deep learning algorithms for detection of hepatic necrosis in toxicity studies. Toxicological Research 2023; 39(3) doi: 10.1007/s43188-023-00173-5
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Hong Yun Kim, Cheol Park, Yung Hyun Choi, Won-Deok Hwang. The Protective Effect of Ethanol Extract of Polygalae Radix against Oxidative Stress-Induced DNA Damage and Apoptosis in Chang Liver Cells. Journal of Korean Medicine for Obesity Research 2019; 19(1) doi: 10.15429/jkomor.2019.19.1.1
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