| For: | Wu XL, Zeng WZ, Jiang MD, Qin JP, Xu H. Effect of Oxymatrine on the TGFbeta-Smad signaling pathway in rats with CCl4-induced hepatic fibrosis. World J Gastroenterol 2008; 14(13): 2100-2105 [PMID: 18395914 DOI: 10.3748/wjg.14.2100] |
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| URL: | https://www.wjgnet.com/1007-9327/full/v14/i13/2100.htm |
| Number | Citing Articles |
| 1 |
Zhangchi Sun, Xiaolan Zhan. Myrrhone inhibits the progression of hepatic fibrosis by regulating the abnormal activation of hepatic stellate cells. Journal of Biochemical and Molecular Toxicology 2022; 36(11) doi: 10.1002/jbt.23177
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| 2 |
Junwei Hu, Shuang Dong, Qinqin Wang, Yicheng Jian, Lijuan Hu, Lijing Wang, Yi He, Genmei Yang, Jinjun Wang, Wujun Xiong. Differentially expressed genes identified by microarray analysis following oxymatrine treatment of hepatic stellate cell. Journal of Biomedical Science and Engineering 2013; 6(08) doi: 10.4236/jbise.2013.68A2007
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| 3 |
Binggang Guan, Rongchun Chen, Mingliang Zhong, Ning Liu, Qin Chen. Protective effect of Oxymatrine against acute spinal cord injury in rats via modulating oxidative stress, inflammation and apoptosis. Metabolic Brain Disease 2020; 35(1) doi: 10.1007/s11011-019-00528-8
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| 4 |
Sukhbir Singh, Neelam Sharma, Saurabh Shukla, Tapan Behl, Sumeet Gupta, Md. Khalid Anwer, Celia Vargas-De-La-Cruz, Simona Gabriela Bungau, Cristina Brisc. Understanding the Potential Role of Nanotechnology in Liver Fibrosis: A Paradigm in Therapeutics. Molecules 2023; 28(6) doi: 10.3390/molecules28062811
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| 5 |
Lianhua Li, Xinhui Huang, Yao Chen, Jibin Liu, Yuhang Qiao, Wenyu Fan, Peiqing Zhang, Xiaoming Yan, Ming Chen. Natural products targeting ubiquitination to combat kidney fibrosis. Future Journal of Pharmaceutical Sciences 2025; 11(1) doi: 10.1186/s43094-024-00757-4
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| 6 |
Baixue Zheng, Looling Tan, Xuejun Mo, Weimiao Yu, Yan Wang, Lisa Tucker-Kellogg, Roy E. Welsch, Peter T. C. So, Hanry Yu, Maria A. Deli. Predicting In Vivo Anti-Hepatofibrotic Drug Efficacy Based on In Vitro High-Content Analysis. PLoS ONE 2011; 6(11) doi: 10.1371/journal.pone.0026230
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| 7 |
Jing Wu, Xueqin Jin, Weihua Li, Enqi Liu. A proteomics-based study of the mechanism of oxymatrine to ameliorate hepatic fibrosis in mice. Journal of Chromatography B 2024; 1247 doi: 10.1016/j.jchromb.2024.124280
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| 8 |
Shao-hua Ren, Bo Shao, Hong-da Wang, Jing-yi Zhang, Hong Qin, Cheng-lu Sun, Yang-lin Zhu, Zhao-bo Wang, Xu Lan, Yong-chang Gao, Hao Wang. Oxymatrine attenuates chronic allograft rejection by modulating immune responses and inhibiting fibrosis. European Journal of Pharmacology 2024; 985 doi: 10.1016/j.ejphar.2024.177082
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| 9 |
Hideaki Shimada, Nicholas R. Staten, Lakshman E. Rajagopalan. TGF-β1 mediated activation of Rho kinase induces TGF-β2 and endothelin-1 expression in human hepatic stellate cells. Journal of Hepatology 2011; 54(3) doi: 10.1016/j.jhep.2010.07.026
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| 10 |
Yini Xu, Hai Xiao, Hong Luo, Yan Chen, Yanyan Zhang, Ling Tao, Yan Jiang, Yuqi Chen, Xiangchun Shen. Inhibitory effects of oxymatrine on TGF-β1-induced proliferation and abnormal differentiation in rat cardiac fibroblasts via the p38MAPK and ERK1/2 signaling pathways. Molecular Medicine Reports 2017; 16(4) doi: 10.3892/mmr.2017.7277
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| 11 |
Christoph Roderburg, Tobias Mollnow, Brenda Bongaerts, Natalia Elfimova, David Vargas Cardenas, Katharina Berger, Henning Zimmermann, Alexander Koch, Mihael Vucur, Mark Luedde, Claus Hellerbrand, Margarete Odenthal, Christian Trautwein, Frank Tacke, Tom Luedde, Robert Lafrenie. Micro-RNA Profiling in Human Serum Reveals Compartment-Specific Roles of miR-571 and miR-652 in Liver Cirrhosis. PLoS ONE 2012; 7(3) doi: 10.1371/journal.pone.0032999
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| 12 |
Mei-Li Lu, Xiao-Hui Xiang, Shi-Hai Xia. Potential Signaling Pathways Involved in the Clinical Application of Oxymatrine. Phytotherapy Research 2016; 30(7) doi: 10.1002/ptr.5632
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| 13 |
Yau-Tuen Chan, Ning Wang, Hor Yue Tan, Sha Li, Yibin Feng. Targeting Hepatic Stellate Cells for the Treatment of Liver Fibrosis by Natural Products: Is It the Dawning of a New Era?. Frontiers in Pharmacology 2020; 11 doi: 10.3389/fphar.2020.00548
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| 14 |
Patrick Ming-Kuen Tang, Hui-Yao Lan. MicroRNAs in TGF-β/Smad-mediated Tissue Fibrosis. Current Pathobiology Reports 2014; 2(4) doi: 10.1007/s40139-014-0060-0
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| 15 |
Ashmita Das, Onkar Kashyap, Devi P. Pandey, Surendra H. Bodakhe. Oxymatrine impedes the progression of endotoxin‐induced glaucoma via redox system modulations. Journal of Biochemical and Molecular Toxicology 2024; 38(1) doi: 10.1002/jbt.23631
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| 16 |
Yanqin Ding, Na Li, Jinhan Sun, Linran Zhang, Jianhui Guo, Xueqi Hao, Yuning Sun. Oxymatrine Inhibits Bocavirus MVC Replication, Reduces Viral Gene Expression and Decreases Apoptosis Induced by Viral Infection. Virologica Sinica 2019; 34(1) doi: 10.1007/s12250-019-00088-2
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| 17 |
Li Li, Dongyuan He, Qin Cai, Dong-ying Wang. Blockage of TGF-β1-induced epithelial-to- mesenchymal transition by oxymatrine prevents renal interstitial fibrosis. Brazilian Journal of Pharmaceutical Sciences 2022; 58 doi: 10.1590/s2175-97902020000118738
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| 18 |
Ruizhou Wang, Xinxin Deng, Qixia Gao, Xiuli Wu, Lu Han, Xiaojuan Gao, Shipeng Zhao, Weibin Chen, Rongrong Zhou, Zhiyong Li, Changcai Bai. Sophora alopecuroides L.: An ethnopharmacological, phytochemical, and pharmacological review. Journal of Ethnopharmacology 2020; 248 doi: 10.1016/j.jep.2019.112172
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| 19 |
Ye Zhang, Xianyi Ding, Muge Zhou, Jialu Shi, Jingru Li, Yuhang Zhu, Meng Ye, Jiabin Wu, Wenhong Wang. Oxymatrine: Hepatoprotective Effects of a Multitarget Natural Alkaloid. Journal of Agricultural and Food Chemistry 2026; doi: 10.1021/acs.jafc.6c00029
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| 20 |
Lorena Avila-Carrasco, Pedro Majano, José Antonio Sánchez-Toméro, Rafael Selgas, Manuel López-Cabrera, Abelardo Aguilera, Guadalupe González Mateo. Natural Plants Compounds as Modulators of Epithelial-to-Mesenchymal Transition. Frontiers in Pharmacology 2019; 10 doi: 10.3389/fphar.2019.00715
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| 21 |
Hans-Theo Schon, Matthias Bartneck, Erawan Borkham-Kamphorst, Jacob Nattermann, Twan Lammers, Frank Tacke, Ralf Weiskirchen. Pharmacological Intervention in Hepatic Stellate Cell Activation and Hepatic Fibrosis. Frontiers in Pharmacology 2016; 7 doi: 10.3389/fphar.2016.00033
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| 22 |
Xiao Ma, Yinxiao Jiang, Jianxia Wen, Yanling Zhao, Jinhao Zeng, Yaoguang Guo. A comprehensive review of natural products to fight liver fibrosis: Alkaloids, terpenoids, glycosides, coumarins and other compounds. European Journal of Pharmacology 2020; 888 doi: 10.1016/j.ejphar.2020.173578
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| 23 |
Xu Lan, Yao Chen, Jia-jia Duan, Jia Xu. Study on Oxymatrine-Based Research from 2001 to 2022: A Bibliometric Analysis. ACS Omega 2024; 9(8) doi: 10.1021/acsomega.3c07880
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| 24 |
Liver targeting effect of vinegar-baked Radix Bupleuri on oxymatrine in mice. 2011 IEEE International Conference on Bioinformatics and Biomedicine Workshops (BIBMW) 2011; doi: 10.1109/BIBMW.2011.6112462
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| 25 |
Yi-cheng Jian, Wei Li, Yi He, Ming Jiang, Yan-bing Liu, Wu-jun Xiong. Effect of oxymatrine on hepatic gene expression profile in experimental liver fibrosis of rats. Chinese Journal of Integrative Medicine 2012; 18(6) doi: 10.1007/s11655-012-1115-x
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| 26 |
Ashmita Das, Onkar Kashyap, Amrita Singh, Jaya Shree, Kamta P. Namdeo, Surendra H. Bodakhe. Oxymatrine Protects TGFβ1-Induced Retinal Fibrosis in an Animal Model of Glaucoma. Frontiers in Medicine 2022; 8 doi: 10.3389/fmed.2021.750342
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| 27 |
Lan‐Lan Lou, Wei Li, Bin‐Hua Zhou, Lin Chen, Han‐Zhuang Weng, Yi‐Hong Zou, Gui‐Hua Tang, Xian‐Zhang Bu, Sheng Yin. (+)‐Isobicyclogermacrenal and spathulenol from Aristolochia yunnanensis alleviate cardiac fibrosis by inhibiting transforming growth factor β/small mother against decapentaplegic signaling pathway. Phytotherapy Research 2019; 33(1) doi: 10.1002/ptr.6219
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| 28 |
Dong‐Liang Fan, Wei‐Jin Zhao, Yu‐Xin Wang, Si‐Yuan Han, Shu Guo. Oxymatrine inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor‐β1/Smad signaling pathway. International Journal of Dermatology 2012; 51(4) doi: 10.1111/j.1365-4632.2011.05234.x
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| 29 |
Ashmita Das, Rahul Manna, Durlav Chowdhury, Dilip Sharma, Surendra H. Bodakhe. Oxymatrine impedes Alzheimer’s progression via the attenuation of hypercholesterolemia and fibrosis. Metabolic Brain Disease 2025; 40(5) doi: 10.1007/s11011-025-01606-w
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| 30 |
Xiang-Chun Shen, Yu-Ping Yang, Ting-Ting Xiao, Jiao Peng, Xing-De Liu. Protective effect of oxymatrine on myocardial fibrosis induced by acute myocardial infarction in rats involved in TGF-β1-Smads signal pathway. Journal of Asian Natural Products Research 2011; 13(3) doi: 10.1080/10286020.2010.550883
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| 31 |
Huipeng Nie, Huanliang Liu, Yue Shi, Tao Yu, Xuan Liu, Wenqing Lai, Lei Tian, Zhuge Xi, Bencheng Lin. miR-31a-5p targeting Crebbp suppresses Wnt/β-catenin and TGF-β pathways to alleviate oil mist particulate matter-induced pulmonary fibrosis. Ecotoxicology and Environmental Safety 2025; 305 doi: 10.1016/j.ecoenv.2025.119266
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| 32 |
Yue Li, Junxian Zhu, Tong Ren, Xiaoli Liu, Chen Chen, Liqin Ji, Xiaoyou Hong, Chengqing Wei, Haigang Chen, Xinping Zhu, Wei Li, Lihong Dang. Cloning and Expression of Col10a1 Gene and Its Response to Wnt/TGF-β Signaling Inhibitors in the Chinese Three-Keeled Pond Turtle (Mauremys reevesii). Animals 2025; 15(22) doi: 10.3390/ani15223315
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| 33 |
Hu Li, Meng-Hao Huang, Jian-Dong Jiang, Zong-Gen Peng. Hepatitis C: From inflammatory pathogenesis to anti-inflammatory/hepatoprotective therapy. World Journal of Gastroenterology 2018; 24(47): 5297-5311 doi: 10.3748/wjg.v24.i47.5297
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| 34 |
Tayebeh Noori, Antoni Sureda, Samira Shirooie. Role of natural mTOR inhibitors in treatment of diabetes mellitus. Fundamental & Clinical Pharmacology 2023; 37(3) doi: 10.1111/fcp.12851
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| 35 |
Xu Lan, Junnan Zhao, Ying Zhang, Yao Chen, Yue Liu, Fengqin Xu. Oxymatrine exerts organ- and tissue-protective effects by regulating inflammation, oxidative stress, apoptosis, and fibrosis: From bench to bedside. Pharmacological Research 2020; 151 doi: 10.1016/j.phrs.2019.104541
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| 36 |
Yang Li, Guan Wang, Jie Liu, Liang Ouyang. Quinolizidine alkaloids derivatives from Sophora alopecuroides Linn: Bioactivities, structure-activity relationships and preliminary molecular mechanisms. European Journal of Medicinal Chemistry 2020; 188 doi: 10.1016/j.ejmech.2019.111972
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| 37 |
Lirong Liu, Yuanyuan Wang, Rui Yan, Shuang Li, Mingjun Shi, Ying Xiao, Bing Guo, Wing-Kin Syn. Oxymatrine Inhibits Renal Tubular EMT Induced by High Glucose via Upregulation of SnoN and Inhibition of TGF-β1/Smad Signaling Pathway. PLOS ONE 2016; 11(3) doi: 10.1371/journal.pone.0151986
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| 38 |
Lan-Lan Lou, Fu-Qiang Ni, Lin Chen, Sharpkate Shaker, Wei Li, Rong Wang, Gui-Hua Tang, Sheng Yin. Germacrane Sesquiterpenoids as a New Type of Anticardiac Fibrosis Agent Targeting Transforming Growth Factor β Type I Receptor. Journal of Medicinal Chemistry 2019; 62(17) doi: 10.1021/acs.jmedchem.9b00708
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| 39 |
Max Kam-Kwan Chan, Jeff Yat-Fai Chung, Philip Chiu-Tsun Tang, Alex Siu-Wing Chan, Johnny Yuk-Yeung Ho, Tony Pak-Tik Lin, Jiaoyi Chen, Kam-Tong Leung, Ka-Fai To, Hui-Yao Lan, Patrick Ming-Kuen Tang. TGF-β signaling networks in the tumor microenvironment. Cancer Letters 2022; 550 doi: 10.1016/j.canlet.2022.215925
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| 40 |
Lei Shi, Xue-Liang Dang, Xin-You Liu, Hua-Mei Wei, Meng-Meng Yang, Yan Zhang. Effect of Sophora flavescens on the pharmacokinetics of carbamazepine in rats. Archives of Pharmacal Research 2014; 37(12) doi: 10.1007/s12272-014-0375-8
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| 41 |
Li-Ying Song, Yu-Tao Ma, Wei-Jin Fang, Yang He, Jia-Li Wu, Shan-Ru Zuo, Zhen-Zhen Deng, Sheng-Feng Wang, Shi-Kun Liu. Inhibitory effects of oxymatrine on hepatic stellate cells activation through TGF-β/miR-195/Smad signaling pathway. BMC Complementary and Alternative Medicine 2019; 19(1) doi: 10.1186/s12906-019-2560-2
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| 42 |
Duong Quang Huan, Nguyen Quang Hop, Ninh The Son. Oxymatrine: A current overview of its health benefits. Fitoterapia 2023; 168 doi: 10.1016/j.fitote.2023.105565
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| 43 |
Hong-wei Zhao, Zhen-fang Zhang, Xuan Chai, Guang-quan Li, He-rong Cui, Hong-bo Wang, Ya-kun Meng, Hui-min Liu, Jia-bo Wang, Rui-sheng Li, Zhao-fang Bai, Xiao-he Xiao. Oxymatrine attenuates CCl 4 -induced hepatic fibrosis via modulation of TLR4-dependent inflammatory and TGF-β1 signaling pathways. International Immunopharmacology 2016; 36 doi: 10.1016/j.intimp.2016.04.040
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