Role of baricitinib in COVID-19 patients: A systematic review and meta-analysis

Table 1 Characteristics of included observational studies

Ref.	Country	Study design	Sample size	Sex		Baricitinib group		Non-baricitinib group
				Male	Female	Number of patients	Death	Number of patients	Death
Hasan et al[14], 2021	Bangladesh	Cohort study	238	159	79	122	4	116	7
Stebbing et al[15], 2021	Italy, Spain	Observational	790	438	352	37	1	142	47
Rodriguez-Garcia et al[16], 2020	Spain	Cohort study	112	78	34	62	5	50	2
Rosas et al[19], 2020	Spain	Case control study	29	20	9	12	2	17	6

Table 2 Characteristics of included clinical trials

Ref.	Country	Study design	Sample size	Sex		Baricitinib group		Non-baricitinib group
				Male	Female	Number of patients	Death	Number of patients	Death
Bronte et al[13], 2020	Italy	Clinical trial	76	38	38	20	1	56	25
Kalil et al[12], 2020	Omaha	Clinical trial	1033	652	381	515	32	518	52
Cantini et al[17], 2020	Germany	Clinical trial	24	20	4	12	0	12	0
Cantini et al[18], 2020	Italy	Clinical trial	191	119	72	113	0	78	7
Cao et al[20],2020	Wuhan	Clinical trial	41	24	17	20	0	21	3
D'Alessio et al[21],2021	Italy	Clinical trial	75	52	23	32	3	43	0
Giudice et al[22], 2020	Italy	Clinical trial	17	13	4	7	1	10	1

Table 3 Quality assessment of observational studies using new castle Ottawa scale

Ref.	Selection	Comparability	Exposure	Total score	Quality of the study
Hasan et al[14], 2021	****	**	***	9	Good
Stebbing et al[15], 2021	***	*	***	7	Good
Rodriguez-Garcia et al[16], 2020	****	*	***	8	Good
Rosas et al[19], 2020	**	**	***	7	Fair

*For each numbered item within the selection and outcome categories.

Table 4 Quality assessment of clinical trials using NIH scale

No.	Ref.	Type of study	Q1	Q2	Q3	Q4	Q5	Q6	Q7	Q8	Q9	Q10	Q11	Q12	Q13	Q14	Quality of the study
1	Bronte et al[13], 2020	Clinical trial	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Good
2	Kalil et al[12], 2020	Clinical trial	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	NR	Yes	Yes	Yes	Yes	Yes	Good
3	Cantini et al[17], 2020	Clinical trial	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Good
4	Cantini et al[18], 2020	Clinical trial	No	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	NO	Yes	Yes	Fair
5	Cao et al[20], 2020	Clinical trial	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Good
6	D'Alessio et al[21], 2021	Clinical trial	No	No	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Fair
7	Giudice et al[22], 2020	Clinical trial	Yes	Yes	Yes	Yes	Yes	Yes	Yes	Yes	NO	Yes	Yes	NO	Yes	NR	Good