Ren LK, Cai ZY, Ran X, Yang NH, Li XZ, Liu H, Wu CW, Zeng WY, Han M. Evaluating the efficacy of endoscopic sphincterotomy on biliary-type sphincter of Oddi dysfunction: A retrospective clinical trial. World J Clin Cases 2021; 9(32): 9835-9846 [PMID: 34877322 DOI: 10.12998/wjcc.v9.i32.9835]
Corresponding Author of This Article
Min Han, MBBS, Chief Doctor, Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Beijing Road, Guiyang 550000, Guizhou Province, China. 409582096@qq.com
Research Domain of This Article
Gastroenterology & Hepatology
Article-Type of This Article
Clinical Trials Study
Open-Access Policy of This Article
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
World J Clin Cases. Nov 16, 2021; 9(32): 9835-9846 Published online Nov 16, 2021. doi: 10.12998/wjcc.v9.i32.9835
Evaluating the efficacy of endoscopic sphincterotomy on biliary-type sphincter of Oddi dysfunction: A retrospective clinical trial
Li-Kun Ren, Zhi-Yuan Cai, Xun Ran, Neng-Hong Yang, Xing-Zhi Li, Hao Liu, Chang-Wei Wu, Wen-Ying Zeng, Min Han
Li-Kun Ren, Zhi-Yuan Cai, Department of General Surgery, The Second Affiliated Hospital of Guizhou University of Traditional Chinese Medicine, Guiyang 550025, Guizhou Province, China
Xun Ran, Neng-Hong Yang, Xing-Zhi Li, Hao Liu, Wen-Ying Zeng, Min Han, Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang 550000, Guizhou Province, China
Chang-Wei Wu, Department of General Surgery, The First People’s Hospital of Bijie City, Bijie 551700, Guizhou Province, China
Author contributions: Ren LK, Cai ZY, Wu CW, Li XZ and Liu H contributed to data collection, arrangement and analysis; Ren LK contributed to writing and modifying the paper; Zeng WY and Yang NH contributed to the editing guidance of the paper; All authors wrote, read and approved the final manuscript.
Institutional review board statement: This study was reviewed and approved by the Affiliated Hospital of Guizhou Medical University Ethics Committee of Medicine. The ethics approval date is March 12, 2020.
Clinical trial registration statement: This study has been registered at Chinese Clinical Trial Registry. The registration identification number is ChiCTR2000034261.
Informed consent statement: Informed written consent was obtained from the patient for publication of this report and any accompanying images.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: No additional data are available.
CONSORT 2010 statement: The authors have read the Consort 2010 Checklist statement, and the manuscript was prepared and revised according to the Consort Checklist (2010).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Min Han, MBBS, Chief Doctor, Department of Hepatobiliary Surgery, Affiliated Hospital of Guizhou Medical University, Beijing Road, Guiyang 550000, Guizhou Province, China. 409582096@qq.com
Received: May 13, 2021 Peer-review started: May 13, 2021 First decision: July 4, 2021 Revised: July 18, 2021 Accepted: September 1, 2021 Article in press: September 1, 2021 Published online: November 16, 2021 Processing time: 180 Days and 10.2 Hours
ARTICLE HIGHLIGHTS
Research background
Although endoscopic sphincterotomy (EST) has a positive therapeutic effect on biliary-type sphincter of Oddi dysfunction (SOD), some patients still have little relief after EST, which implies that other functional abdominal pain may also be present with biliary-type SOD and interfere with the diagnosis and treatment of it.
Research motivation
This study explored the efficacy of EST in the treatment of biliary-type SOD and analyzed the reasons for the uncertainty of the efficacy of EST in the treatment of this kind of patients, that is, with FGID. The combined treatment of this kind of patient is the key to improve the efficacy of EST in the treatment of biliary-type SOD.
Research objectives
The objective was to investigate the therapeutic effect of EST in biliary-type SOD and analyze the reasons for the uncertainty of its curative effect to improve the curative effect of endoscopic therapy in this type patients.
Research methods
This study compared and analyzed the clinical remission of different types of SOD patients after EST, including indicators such as postoperative pain, transaminase recovery and so on. The follow-up time was long, and the number of cases was sufficient.
Research results
This study suggested that EST is a minimally invasive, safe and effective treatment. For patients with type I and II SOD combined with FGID, single EST or medical treatment has limited efficacy. It is recommended that EST and medicine be combined to improve the cure rate of such patients. There are deficiencies in this study, but it is mainly a retrospective study. It is difficult to accurately diagnose SOD in patients with FGID, and more prospective randomized trials are needed to confirm.
Research conclusions
EST is a minimally invasive, safe and effective treatment. For patients with type I and II SOD combined with FGID, single EST or medical treatment has limited efficacy. It is recommended that EST and medicine be combined to improve the cure rate of such patients.
Research perspectives
There is a close relationship between FGID and biliary-type SOD, and more prospective randomized trials are needed to clarify their relationship in the future.
