Anticonvulsant potential of rosuvastatin in combination with carbamazepine and valproate in animal models of epilepsy

Table 1 Tonic hind limb extension in maximal electroshock induced seizures in mice (n = 6)

Treatment groups	THLE present	% with THLE present
Vehicle (control group)	6	100.00%
Carbamazepine 4 mg/kg	0	0.00%a
Carbamazepine 6 mg/kg	0	0.00%a
Carbamazepine 8 mg/kg	0	0.00%a
Rosuvastatin 10 mg/kg	5	83.33%
Rosuvastatin 20 mg/kg	4	66.67%
Rosuvastatin 30 mg/kg	4	66.67%
Rosuvastatin 10 mg/kg + carbamazepine 4 mg/kg	0	0.00%a

^aP value < 0.05 in comparison with control group (Fischer exact test).

THLE: Tonic hind limb extension.

Table 2 Mean duration of tonic hind limb extension in maximal electroshock induced seizures in mice (n = 6)

Treatment groups	Mean duration of tonic hind limb extension (seconds)	SEM
Vehicle (control group)	6.73	0.51
Carbamazepine 4 mg/kg	0a	0
Carbamazepine 6 mg/kg	0a	0
Carbamazepine 8 mg/kg	0a	0
Rosuvastatin 10 mg/kg	5.80	1.18
Rosuvastatin 20 mg/kg	4.47	1.41
Rosuvastatin 30 mg/kg	4.93	1.58
Rosuvastatin 10 mg/kg + carbamazepine 4 mg/kg	0a	0

^aP value < 0.05 in comparison with control group (Dunn Post hoc analysis).

Table 3 Duration of seizure activity in maximal electroshock induced seizures in mice (n = 6)

Treatment groups	Mean duration of seizure (seconds)	SEM
Vehicle (control group)	22.00	1.09
Carbamazepine 4 mg/kg	14.37	0.68
Carbamazepine 6 mg/kg	11.63	0.39
Carbamazepine 8 mg/kg	10.33a	0.58
Rosuvastatin 10 mg/kg	23.80	1.14
Rosuvastatin 20 mg/kg	21.13	0.74
Rosuvastatin 30 mg/kg	22.53	0.61
Rosuvastatin 10 mg/kg + carbamazepine 4 mg/kg	10.20a	0.60

^aP value < 0.05 in comparison with control group (Dunn Post hoc analysis).