Role of the phase angle in the prognosis of the cirrhotic patient: 15 years of follow-up

Table 1 Characterization of the sample, n (%)

Variáveis	Total, n = 129
Age (yr), mean ±SD	56.32 ± 11.25
Gender
Male	73 (56.6)
Female	56 (43.4)
Weight (kg), mean ± SD	74.46 ± 14.69
Height (m), mean ± SD	164.43 ± 8.97
Phase angle, mean ± SD	6.62 ± 2.95
Etiology Cirrhosis
Alcohol	31 (24)
Autoimmune	5 (3.90)
Nash	5 (3.90)
Others	16 (12.5)
Virus C	56 (43.40)
Virus C+ alcohol	12 (9.30)
Virus B	4 (3.10)
Meld, mean ± SD	10.98 ± 4.69
Classification Child-Turcotte-Pugh
Child A	85 (65.89)
Child B	33 (25.59)
Child C	11 (8.52)

NASH: Non-alcoholic steatohepatitis

Table 2 Clinical outcomes according to phase angle classifications, n (%)

Variable	n = 129	< 5.4, n = 89	> 5.4, n = 40	< 50, n = 56	> 50, n = 73	mean ± SD, PA
Deaths from the 1st year to the 5th year (1-60 mo)	41	17 (41.46)	24 (58.53)	22 (53.65)	18 (46.35)	5.81 ± 1.87
Deaths from the 6th to the 10th year (61-120 mo)	19	7 (36.84)	12 (63.15)	10 (52.63)	9 (47.36)	6.63 ± 3.21
Deaths from the 11th to the 15th year (121-180 mo)	6	1 (16.67)	5 (83.33)	2 (33.34)	4 (66.66)	6.65 ± 1.90
Alive not transplanted	45	6 (13.33)	39 (86.66)	11 (24.44)	34 (75.55)	7.04 ± 3.07
Alive transplanted	10					8.62 ± 5.48
Dead transplanted	8	4 (50)	4 (50)	6 (75)	2 (25)	5.75 ± 1.01
Deaths from the 1st year to the 5th year (1-60 mo)	3	1 (33.33)	2 (66.67)	1 (33.33)	2 (66.67)	6.57 ± 1
Deaths from the 6th to the 10th year (61-120 mo)	4	2 (50)	2 (50)	4 (100)	-	5.28 ± 0.56
Deaths from the 11th to the 15th year (121-180 mo)	1	1 (100)	0	1 (100)	-	5.19 ± 0

Results expressed by mean ± SD, median ± SD or n (%).

Table 3 Clinical outcomes according to phase angle classifications, %

Variables	Total, n = 129	< P50, n = 56	> P50, n = 73
Deaths	57.4	71.40	46.60
SPB	18.6	23.2	15
Ascites	57	66.1	50.70
Paracentesis	30.20	32.10	28.80
EV	75	82.10	69.90
Varicose veins bleeding	10	10.71	10.95
Encephalopathy	34.9	46.40	26
HCC	8.50	10.70	6.80

SPB: Spontaneous bacterial peritonitis; EV: Esophageal varices; HCC: Hepatocellular carcinoma.

Table 4 Biomarkers according to percentil classification

Variable	P < 50, n = 56	P > 50, n = 73	P value
GOT (mg/dL) mean ± Dp	128 ± 428	71 ± 47	0.27
GPT (mg/dL) mean ± Dp	79 ± 227	58 ± 42	0.46
GGT (mg/dL) mean ± Dp	102 ± 80	94 ± 103	0.69
ALP (mg/dL) mean ± Dp	117.4 ± 55.1	101.4 ± 54.6	0.13
Albumin (g/dL) mean ± Dp	3.6 ± 1.9	3.9 ± 0.6	0.34
Total Bilirubin (mg/dL) mean ± Dp	2.4 ± 2.6	1.7 ± 1.2	0.02a
Direct Bilirubin (mg/dL) mean ± SD	1 ± 1.1	0.7 ± 0.5	0.02a
Indirect bilirubin (mg/dL) mean ± SD	1.3 ± 1.5	0.9 ± 0.9	0.10
Urea (mg/dL) mean ± SD	36 ± 16	36 ± 13	0.79
Creatinine (mg/dL) mean ± SD	1 ± 0.3	1 ± 0.2	0.64
Sodium (mg/dL) mean ± SD	137 ± 4	139 ± 4	0.03a
Potassium (mg/dL) mean ± SD	4.6 ± 2	4.9 ± 2.7	0.32
INR mean ± SD	1.36 ± 0.38	1.45 ± 0.51	0.02a

^aT test for independent samples.

GOT: Oxaloacetic Transaminase; GPT: Pyruvic Transaminase; ALP: Alkaline phosphatase; INR: International normalized ratio.