Meta-Analysis
Copyright ©The Author(s) 2022.
World J Methodol. Jul 20, 2022; 12(4): 319-330
Published online Jul 20, 2022. doi: 10.5662/wjm.v12.i4.319
Table 1 Baseline demographics and clinical characteristics of included studies
Ref.Age, yearInterventionComparisonsSample size (intervention/comparisons)Outcomes of interest
Yavuz et al[16], 2020, Turkey36.8 ± 11.4IV metoclopramide 10 mg1 IV dexketoprofen trometamol 50 mg; 2 IV dexketoprofen trometamol 50 mg plus IV metoclopramide 10 mg150 (50/50/50)VAS at 0, 15, and 30 min, adverse effects, and requirement of rescue medicine
Khazaei et al[17], 2019, Iran36.8 ± 9.9IV metoclopramide 10 mg1 IV dexamethasone 8 mg; 2 IV ketorolac 30 mg; 3 IV chlorpromazine 25 mg128 (32/32/32/32)VAS at 0 min, 60 min, and 24 h, adverse effects
Doğan et al[18], 2019, Turkey34 ± 13.3IV metoclopramide 10 mg1 Placebo148 (74/74)Pain intensity at 30 min, adverse effects, and requirement of rescue analgesicChange in pain intensity, additional ED visit in 24-72 h after discharge
Amiri et al[19], 2017, Iran33.5IV metoclopramide 10 mg1 IV granisetron 2 mg148 (73/75)VAS before and at 1, 2, and 4 h after drug administration, emesis episode
Friedman et al[20], 2014, USA33.7 ± 13.1IV metoclopramide 10 mg1 IV sodium valproate 1000 mg; 2 IV ketorolac 30 mg330 (110/110/110)Verbal NRS and ordinal pain scale every 30 min, adverse effects, and requirement of rescue medication
Talabi et al[21], 2013, Iran30.9 ± 8.0IV metoclopramide 20 mg1 SC sumatriptan 6 mg124 (62/62)VAS at 0 and 60 min
Friedman et al[22], 2004, Turkey34 ± 4.4IV metoclopramide 20 mg1 SC sumatriptan 6 mg78 (40/38)NRS at 0, 2, and 24 h, and rate of pain free headache response at 2 and 24 h, rate of modified headache response, associated symptoms, satisfaction, disability score, and requirement for rescue drug
Cete et al[10], 2004, Iran40 ± 12IV metoclopramide 10 mg1 IV magnesium sulphate 2 g; 2 Placebo113 (37/36/40)VAS at 0, 15, and 30 min, additional analgesic, rescue medication, adverse events in ED, and recurrence rate at 24 h
Ellis et al[23], 1993, USAN/AIV metoclopramide 10 mg1 Oral ibuprofen 600 mg; 2 IV metoclopramide 10 mg + PO ibuprofen 600 mg; 3 Placebo40 (10/10/10/10)VAS and nausea scores at 0, 30, and 60 min, requirement of rescue medication
Cameron et al[24], 1995, USA32.1 ± 27.0IV metoclopramide 10 mg1 IV chlorpromazine 0.1 mg/kg91 (44/47)VAS at 0 and every 15 min, requirement of rescue drug
Friedman et al[25], 2008, USA36.0 ± 11.1IV diphenhydramine 25 mg + IV metoclopramide 20 mg1 IV diphenhydramine 25 mg + IV prochlorperazine 10 mg77 (38/39)NRS and pain intensity categorical scale at 0 and every 30 min
Coppola et al[26], 1995, USAN/AIV metoclopramide 10 mg1 IV chlorpromazine 10 mg; 2 Placebo70 (24/22/24)VAS, nausea, and sedation at 0 and 30 min. Early relapse rate in 48 h
Gaffigan et al[27], 2015, USA29 ± 7.9IV diphenhydramine 25 mg + IV metoclopramide 10 mg1 IV diphenhydramine 25 mg + IV haloperidol 5 mg64 (33/31)Pain, nausea, restlessness, and sedation at 0, 20, 40, 60, and 80 min, requirement of rescue medication, patient satisfaction, adverse events, early discharge, ED revisit, and QT interval
Tek et al[28], 1990, USAN/AIV metoclopramide 10 mg1 Placebo50 (24/26)Degree of pain relief at 1 h after treatment