Pancreatic nerves across species: Anatomical and functional disparities and their metabolic ramifications

Figure 1 Pancreatic nerve variations across species and metabolic implications. This illustration summarizes the significant interspecies disparities in pancreatic neuroanatomy and their metabolic implications. It comparatively depicts the intricate neural plexus in humans, clustered nerve trunks in rodents, and structurally similar yet distinct innervation in canines/felines. The graphic highlights how these anatomical variations influence autonomic regulation of endocrine secretion (insulin/glucagon), contributing to differential disease susceptibilities and therapeutic responses. Understanding these species-specific characteristics is crucial for improving translational research, guiding neural reconstruction in pancreatic transplantation, and developing targeted therapies for metabolic disorders like diabetes and pancreatitis.