Rationalising animal research synthesis in orthopaedic literature

Figure 1 Forest plot of standardised mean differences with multiple subgroup analyses is demonstrated. The methicillin-resistant Staphylococcus aureus infection prevention potential is assessed by means pair-wise meta-analysis in inverse variance mode to consider not only continuous but also dichotomous data in the analysis. CI： Confidence interval; CSA: Cationic steroidal antimicrobial; HA: Hydroxyapatite; SMD: Standardised mean difference; IV: Inverse variance; PA: Periapatite; PLEX: Polymer-lipid encapsulation matrix; SE: Standard error; TiO2 = Titanium dioxide. Citation: Tsikopoulos K, Sidiropoulos K, Kitridis D, Hassan A, Drago L, Mavrogenis A, McBride D. Is coating of titanium implants effective at preventing Staphylococcus aureus infections? A meta-analysis of animal model studies. Int Orthop 2020. Copyright© The Author(s) 2020. Published by Springer Nature Publishing Group[5]. The authors have obtained the permission for figure using from the Springer Nature Publishing Group (Supplementary material).

Figure 2 Quantification of risk of bias assessment enables not only summarising quality appraisal results but also making judgments as to what the future studies should look at. Citation: Tsikopoulos K, Sidiropoulos K, Kitridis D, Hassan A, Drago L, Mavrogenis A, McBride D. Is coating of titanium implants effective at preventing Staphylococcus aureus infections? A meta-analysis of animal model studies. Int Orthop 2020. Copyright© The Author(s) 2020. Published by Springer Nature Publishing Group[5]. The authors have obtained the permission for figure using from the Springer Nature Publishing Group (Supplementary material).