Long-term adipocytokine changes after Roux-en-Y gastric bypass and laparoscopic sleeve gastrectomy: A comparative minireview

Table 1 Database-specific search strategies used for the narrative minireview

Database	Search strategy
PubMed	("bariatric surgery"[Title/Abstract] OR "Roux-en-Y gastric bypass"[Title/Abstract] OR "sleeve gastrectomy"[Title/Abstract]) AND (adipokine*[Title/Abstract] OR adipocytokine*[Title/Abstract] OR leptin[Title/Abstract] OR adiponectin[Title/Abstract] OR resistin[Title/Abstract] OR chemerin[Title/Abstract])
Scopus	TITLE-ABS-KEY("bariatric surgery" OR "Roux-en-Y gastric bypass" OR "sleeve gastrectomy") AND TITLE-ABS-KEY(adipokine* OR adipocytokine* OR leptin OR adiponectin OR resistin OR chemerin)
Web of Science	TS=("bariatric surgery" OR "Roux-en-Y gastric bypass" OR "sleeve gastrectomy") AND TS=(adipokine* OR adipocytokine* OR leptin OR adiponectin OR resistin OR chemerin)
EMBASE	('bariatric surgery':ti,ab,kw OR 'Roux-en-Y gastric bypass':ti,ab,kw OR 'sleeve gastrectomy':ti,ab,kw) AND (adipokine*:ti,ab,kw OR adipocytokine*:ti,ab,kw OR leptin:ti,ab,kw OR adiponectin:ti,ab,kw OR resistin:ti,ab,kw OR chemerin:ti,ab,kw)
Cochrane Library	("bariatric surgery" OR "Roux-en-Y gastric bypass" OR "sleeve gastrectomy"):ti,ab,kw AND (adipokine* OR adipocytokine* OR leptin OR adiponectin OR resistin OR chemerin):ti,ab,kw

Search limits: Database inception through June 2026; English-language full text. No study-design filter was applied at the search stage. RYGB: Roux-en-Y gastric bypass; LSG: Laparoscopic sleeve gastrectomy.

Table 2 Direct comparative evidence for adipokine changes after Roux-en-Y gastric bypass vs laparoscopic sleeve gastrectomy

Adipokine	Direct comparative findings	Design and follow-up	Interpretation and limitations
Leptin	Randomized and larger prospective studies show similar 12-month reductions after RYGB and LSG[78-80]	7-18 months; one randomized trial and several small cohorts	Broadly comparable when weight loss is similar; isolated nonrandomized differences may reflect confounding[84]
Adiponectin	Both procedures increase adiponectin. Some cohorts favor RYGB[83,84], whereas another found comparable high-molecular-weight adiponectin[82]	7-12 months; small nonrandomized studies	Mixed evidence; no durable procedure-specific superiority established
Resistin	Few direct comparisons; small observational studies report inconsistent between-procedure differences[36,86]	6-12 months; limited observational evidence	Insufficient evidence; weight loss, diabetes, and vitamin D may confound
Chemerin	Two prospective cohorts report similar decreases after RYGB and LSG at 12 months[78,79]	6 and 12 months; prospective nonrandomized cohorts	Probably comparable at 12 months, but no adequately powered randomized long-term study

RYGB: Roux-en-Y gastric bypass; LSG: Laparoscopic sleeve gastrectomy.