Secondary amyloidosis in autoinflammatory diseases and the role of inflammation in renal damage

Table 1 Pathogen associated molecular pattern and damage associated molecular pattern that trigger nod-like receptor protein-3 activation[12]

Type	Molecule/molecular pattern
PAMP	Leptospiral interrogans/glycolipoprotein
	Influenza
	Streptococcus pyogenes/streptolysin O
	Staphylococcus aureus/alpha hemolysin
DAMP	ATP
	Nigericin
	Histones
	U1snRNP ribonucleoprotein
	dsDNA/nucleosomes
	MSU crystals
	Uromodulin
	Biglycan
	Silica
	Alum
	Calcium oxalate
	Asbestos
	Amyloid-β
	Hemazoin
	Hyaluronan

PAMP: Pathogen associated molecular pattern; DAMP: Damage associated molecular pattern; ROS: Reactive oxygen species/oxidative stress; PAMP: Pathogen-associated molecular pattern; DAMP: Damage-associated molecular pattern; ATP: Adenosine tri phosphate; MSU: Mono sodium urate.

Table 2 Over 30 proteins capable of amyloid formation have been identified

Immunoglobulin light chains in primary systemic amyloidosis

Ig heavy chain

Beta2-microglobulin in dialysis-associated arthropathy

Amyloid beta protein in alzheimer disease and down syndrome

Hereditary forms (including transthyretin, apolipoprotein A-I and A-II, gelsolin, lysozyme, fibrinogen a-alpha chain

Amyloid a in secondary amyloidosis