ACE and ACE2 in kidney disease

Table 1 Renal angiotensin-converting enzyme and angiotensin-converting enzyme 2 protein expression in various diseases

Diseases	Species	Glomerular	Tubular	Glomerular	Tubular	Ref.	Year
		ACE	ACE	ACE2	ACE2
Type 1 DM	Rats	↑	↓	↑	↓	Tikellis et al[30]	2003
Type 2 DM	Mice	ND	↓	ND	↑	1Ye et al[9]	2004
Type 2 DN	Mice	↑	↓	↓	↑	Ye et al[14]	2006
Type 1 DM	Rats	↑	↑	↓	↑	Moon et al [31]	2008
Type 2 DN	Mice	ND	ND	↓	↑	Chodavarapu et al[32]	2013
Type 2 DN	Humans	ND	ND	↑	↑	Lely et al[34]	2004
Type 2 DN	Humans	↑	↑	↓	↓	Mizuiri et al[15]	2007
Type 2 DN	Humans	↑	↑	↓	↓	Reich et al[16]	2007
Primary glomerulopathy	Humans	ND	ND	↑	-	Lely et al[34]	2004
IgA nephropathy	Humans	↑	↑	↓	↓	Mizuiri et al[36]	2011
Hypertension	Rats	ND	ND	↓1		Prieto et al[41]	2011
Hypertension	Humans	↑1		↓1		Koka et al[45]	2008
Nephrosclerosis	Humans	-	↓	-	↓	Wang et al[22]	2011
Subtotal nephrectomy	Rats	ND		↓1		Velkoska et al[46]	2009
Subtotal nephrectomy	Rats	↑1		↓1		Eräranta et al[47]	2012

¹No description about expression pattern of glomerular and tubular ACE and ACE2. DM: Diabetes mellitus; DN: Diabetic nephropathy; ND: Not done; ACE: Angiotensin-converting enzyme; -: No changes.