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©The Author(s) 2024.
World J Nephrol. Mar 25, 2024; 13(1): 90402
Published online Mar 25, 2024. doi: 10.5527/wjn.v13.i1.90402
Published online Mar 25, 2024. doi: 10.5527/wjn.v13.i1.90402
Ref. | Country | Patients | Design | Study period | Number of cases | Mean age (yr) | Gender M/F |
Hajji et al[4], 2019 | Tunisia | ADPKD | Observational descriptive | 1969-2016 | 569 | 48.5 | 297/272 |
Arogundade et al[5], 2018 | Nigeria | ADPKD | Observational descriptive | 1996-2010 | 41 | 48.6 4.6 | 23/18 |
Chijioke et al[6], 2010 | Nigeria | ADPKD | Observational descriptive | 1994-2009 | 78 | 49.8 3.6 | 52/26 |
Ogiator et al[7], 2021 | Nigeria | ADPKD | Observational descriptive | 2013-2020 | 19 | 42.8 16.9 | 10/9 |
Mawufemo et al[8], 2018 | Togo | ADPKD | Observational descriptive | 2010-2017 | 27 | 51.6 16.4 | 10/17 |
Fary Ka et al[9], 2010 | Senegal | ADPKD | Observational descriptive | 1995-2005 | 55 | 47.0 5.0 | 31/24 |
Okyere et al[10], 2021 | Ghana | ADPKD | Observational descriptive | 2007-2018 | 82 | 43.8 15.7 | 43/39 |
Laleye et al[11], 2012 | Benin | ADPKD | Observational descriptive | 2000-2010 | 32 | 47.2 | 17/15 |
Abdelwahed et al[12], 2022 | Tunisia | ADPKD | Observational descriptive | NA | 19 | 47 18 | 10/9 |
Abdelwahed et al[13], 2018 | Tunisia | ADPKD | Observational descriptive | NA | 18 | 45 | 8/10 |
Seck et al[14], 2013 | Senegal | ADPKD | Case report | NA | 1 | 41 | 0/1 |
Sahnoun et al[16], 2015 | Tunisia | ADPKD | Case report | NA | 1 | 52 | 1/0 |
Nabhan et al[15], 2015 | Egypt | ARPKD | Case report | NA | 1 | 2.5 | 0/1 |
Total | 943 | 47.9 | 502/441 |
Ref. | HTN (%) | Pain (%) | Hematuria (%) | Abdominal mass (%) | KFI (%) | ESKD (%) |
Hajji et al[4], 2019 | 58.8 | 51.9 | 24.6 | 66.0 | 74.7 | 23.0 |
Arogundade et al[5], 2018 | 87.8 | 68.3 | 36.6 | 82.9 | 100.0 | 19.5 |
Chijioke et al[6], 2010 | 26.9 | 14.1 | NA | NA | 32.0 | NA |
Ogiator et al[7], 2021 | 42.1 | 68.4 | 31.6 | NA | 63.2 | 15.8 |
Mawufemo et al[8], 2018 | 77.8 | 63.0 | 22.2 | 63.0 | 63.0 | 25.9 |
Fary Ka et al[9], 2010 | 65.4 | 52.7 | 25.4 | NA | NA | NA |
Okyere et al[10], 2021 | 50.0 | 39.0 | 2.4 | NA | 81.7 | 15.9 |
Laleye et al[11], 2012 | 59.0 | 62.0 | 46.0 | 43.0 | 72.0 | NA |
Abdelwahed et al[12], 2022 | 57.9 | NA | 26.3 | NA | 89.5 | NA |
Abdelwahed et al[13], 2018 | 72.2 | NA | NA | NA | NA | NA |
Pooled prevalence [95%IC] | 57.4 [54.2–60.6] | 49.1 [45.8–52.3] | 24.0 [21.1–26.9] | 65.8 [62.2–69.4] | 72.1 [69.1–75.1] | 21.9 [18.9–24.9] |
Gene | Exon/Intron | Nucleotide change | Aminoacid change | Number of patients | Ref. |
PKD 1 | 4 | c.496 C>T | p.L166 | 2 | [12] |
5 | c.696 T>G | p.C232W | 2 | [12,13] | |
5 | c.688 T>G | p.C230G | 1 | [12] | |
5 | c.690 C>G | p.C230W | 1 | [12] | |
7 | c.1522 T>C | p.C508R | 1 | [12] | |
8 | c.1702 G>A | p.A568T | 1 | [12] | |
9 | c.1745_1761dup | NA | 1 | [11] | |
15 | c.4264 G>A | p.A1422T | 1 | [12] | |
15 | c.5577 T>C | p.A1859 | 1 | [12] | |
15 | c.4495 C>T | p.L1499 | 2 | [12] | |
15 | NA | p.Q1651X | 1 | [11] | |
15 | NA | p.W1666X | 1 | [11] | |
15 | NA | c.6575_6581del | 1 | [11] | |
18 | c.7290_7291delinsCTGCA | NA | 2 | [11,14] | |
IVS22 | c.8161-1 G>A | Likely silent | 4 | [12] | |
IVS42 | c.11712+28 C>T | Likely silent | 1 | [12] | |
23 | c.8679 C>G | p.S893 | 1 | [12] | |
23 | c.8715 C>T | p.V2905 | 1 | [12] | |
23 | c.8748 T>C | p.P2916 | 2 | [12] | |
23 | c.8522 A>G | p.N2841S | 1 | [12] | |
23 | NA | p.Q2824X | 1 | [11] | |
26 | c.9397+1_9397+8del | NA | 1 | [11] | |
28 | c.9669 G>A | p.T3223 | 2 | [12] | |
30 | c.3367G>A | p.G1123S | 1 | [15] | |
31 | c.10165 G>C | p.E3389Gln | 1 | [12] | |
44 | c.12133 A>G | p.I4045V | 1 | [12] | |
45 | c.12276 A>G | p.A4092 | 2 | [12,16] | |
PKD 2 | 1 | c.568 G>A | p.A190T | 2 | [12] |
1 | c.83 G>C | p.A28P | 2 | [12] | |
IVS1 | c.596-16 C>T | Likely silent | 1 | [12] | |
PKHD1 | c.3367G>A | p.G1123S | 1 | [15] |
- Citation: Ndongo M, Nehemie LM, Coundoul B, Diouara AAM, Seck SM. Prevalence and outcomes of polycystic kidney disease in African populations: A systematic review. World J Nephrol 2024; 13(1): 90402
- URL: https://www.wjgnet.com/2220-6124/full/v13/i1/90402.htm
- DOI: https://dx.doi.org/10.5527/wjn.v13.i1.90402